Delirium is a serious, acute neuropsychiatric syndrome characterized by a sudden onset of disturbed attention, awareness, and cognition that develops over a short period, typically hours to days, and fluctuates in severity throughout the day.[1] Delirium is not a disease itself but a clinical syndrome indicating disturbance in brain function due to one or more underlying medical conditions or physiological stressors. It represents a change from an individual's baseline mental functioning and is usually precipitated by an underlying medical condition or physiological stressor, distinguishing it from chronic conditions like dementia.[2] Unlike more gradual cognitive declines, delirium is often reversible with prompt identification and treatment of its cause, though it can persist for weeks or months in some cases.[3]The clinical presentation of delirium varies but commonly includes core features such as inattention (difficulty focusing or sustaining attention), disorganized thinking (manifesting as rambling or incoherent speech), and an altered level of consciousness (ranging from hyperalertness to drowsiness).[1] Additional symptoms may involve disorientation to time, place, or person; perceptual disturbances like hallucinations; sleep-wake cycle disruptions; and emotional changes such as anxiety, agitation, or apathy.[2] Delirium is classified into three main subtypes: hyperactive (characterized by restlessness, agitation, and increased psychomotor activity), hypoactive (marked by lethargy, reduced responsiveness, and withdrawal, which is often underrecognized), and mixed (alternating between hyperactive and hypoactive features).[3] Diagnosis relies on clinical criteria from the DSM-5, which emphasize the acute nature, fluctuation, and evidence of an underlying organic cause, often confirmed using tools like the Confusion Assessment Method (CAM) with high sensitivity (94-100%).[1]Delirium arises from a multifactorial interplay of predisposing vulnerabilities and precipitating factors, with no single pathophysiological mechanism but common pathways involving neuroinflammation, oxidative stress, and imbalances in neurotransmitters like acetylcholine and dopamine.[1] Precipitants include infections (e.g., urinary tract or pneumonia), medication effects or withdrawal (accounting for up to 39% of cases, such as from sedatives or opioids), metabolic derangements (e.g., electrolyte imbalances or dehydration), surgery or anesthesia, and organ failure.[1] Risk factors prominently feature advanced age (over 70 years), preexisting cognitive impairment like dementia, multiple comorbidities, sensory deficits (e.g., vision or hearing loss), and hospitalization or intensive care unit stays, which amplify vulnerability through environmental stressors.[2]Epidemiologically, delirium affects a significant portion of vulnerable populations, with prevalence rates of 10-20% following major surgery, up to 50% after high-risk procedures like cardiac surgery, and 20-30% among hospitalized older adults.[1] It is associated with substantial morbidity, including prolonged hospital stays (by 2-3 days on average), increased risk of complications like falls, aspiration pneumonia, and pressure ulcers, and higher mortality (70% increased risk of death at six months in emergency department cases).[1] As of 2023, annual U.S. healthcare costs attributable to delirium are estimated at over $164 billion, with projections reaching $254 billion by 2025, underscoring its public health burden, while long-term sequelae may include persistent cognitive decline and greater need for institutional care.[1][4] Prevention strategies, such as the Hospital Elder Life Program, can reduce incidence by up to 40% through nonpharmacologic interventions like orientation protocols, mobility encouragement, and medication reconciliation.[1] Management prioritizes identifying and correcting the underlying cause, alongside supportive measures and cautious use of antipsychotics for severe agitation, emphasizing an interprofessional team approach for optimal outcomes.[1]
Definition and Classification
Definition
Delirium is defined as an acute and fluctuating disturbance in attention and awareness that develops over a short period, typically hours to days, and is accompanied by additional disturbances in cognition.[5][6] This syndrome represents a change from the individual's baseline level of functioning and tends to fluctuate in severity over the course of a day, often with a waxing and waning pattern.[5] The core features include reduced ability to direct, focus, sustain, and shift attention, along with diminished awareness of the environment, and an additional cognitive impairment such as memory deficit, disorientation, perceptual disturbances, or problems with language or visuospatial ability.[5][6]According to the DSM-5-TR criteria, the diagnosis requires that these disturbances are not better explained by a preexisting, established, or evolving neurocognitive disorder, such as dementia, and do not occur in the context of severely reduced arousal like coma.[5] Furthermore, there must be evidence from history, physical examination, or laboratory findings indicating that the delirium is a direct physiological consequence of another medical condition, substance intoxication or withdrawal, exposure to a toxin, or multiple etiologies.[5] The ICD-11 similarly describes delirium as a syndrome involving a disturbance in attention, awareness, and cognition with rapid onset and fluctuation, linked to an underlying physical cause and not attributable to another primary mental disorder.[6] These criteria emphasize the global nature of the cognitive impairment and altered level of consciousness, distinguishing delirium as a potentially reversible syndrome when the underlying cause is addressed.[7]The term "delirium" originates from the Latin verb delirare, meaning "to deviate from the furrow" (as in plowing a straight line), which metaphorically reflects historical conceptions of mental derangement or deviation from rational thought.[7] This etymology underscores the condition's characterization as a temporary disruption in mental clarity, first documented in medical literature by the RomanphysicianCelsus in the 1st century AD.[7]
Subtypes
Delirium is classified into subtypes based on psychomotor behavior and arousal levels, primarily hyperactive, hypoactive, mixed, and non-motoric (or no-subtype).[8][9] Hyperactive delirium features agitation, restlessness, and hallucinations, while hypoactive delirium involves lethargy, withdrawal, and reduced responsiveness.[10] Mixed delirium fluctuates between hyperactive and hypoactive features, and the non-motoric subtype presents with cognitive impairments without prominent motor changes.[11][9]Hypoactive delirium is the most prevalent subtype, accounting for up to 50% of cases in various settings, though it is frequently underrecognized due to its subtle presentation.[12][13] In intensive care units, hypoactive forms can represent over 50% of delirium episodes, often misattributed to underlying illness or sedation.[14]Patients with hypoactive delirium experience worse clinical outcomes compared to other subtypes, including higher mortality rates and prolonged hospital stays.[15][16] This subtype is linked to increased in-hospital mortality risk and poorer long-term prognosis, potentially due to delayed detection.[9][17]Recent guidelines from 2025, including updates from the American Psychiatric Association and the Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption (PADIS) principles, emphasize the hypoactive subtype due to its subtlety and association with sedative use in critical care, calling for improved screening and subtype-specific strategies.[18][19]
Signs and Symptoms
Core Features
Delirium is fundamentally characterized by a disturbance in attention and awareness, manifesting as a reduced ability to direct, focus, sustain, or shift attention, often accompanied by disorientation to the environment.[5] This core attentional deficit impairs the individual's capacity to engage with their surroundings, leading to disorganized thinking where thoughts become fragmented, tangential, or incoherent.[1] An altered level of consciousness is also central, ranging from mild clouding to profound lethargy or hyperarousal, which further disrupts cognitive processing and behavioral regulation.[7]Cognitive impairments in delirium typically include disorientation to time, place, or person, alongside deficits in memory, particularly short-term recall, where patients struggle to register new information or retrieve recent events.[1] Perceptual disturbances are common, such as illusions where familiar stimuli are misinterpreted, though these differ from the more structured hallucinations seen in other psychiatric conditions.[7] These features collectively contribute to a global cognitive dysfunction that affects orientation, language, and visuospatial abilities, underscoring delirium's impact on higher mental functions.[5]Associated autonomic changes often involve disruption of the sleep-wake cycle, with fragmented sleep, insomnia, or reversal of day-night patterns, exacerbating overall vulnerability.[1]Emotional lability is another hallmark, presenting as rapid shifts in mood, irritability, anxiety, or apathy, which can intensify interpersonal and self-regulatory challenges.[7]The temporal pattern of delirium is marked by an acute onset, developing over hours to days, with prominent diurnal fluctuations where symptoms worsen at night or during periods of fatigue.[1] This fluctuating course distinguishes it from more stable neurocognitive disorders, and the syndrome typically resolves upon addressing the underlying cause, though persistence can occur in some cases.[7]
Variations by Subtype
Delirium manifests differently across its motor subtypes, with variations in psychomotor activity, arousal, and behavioral presentations that influence clinical recognition and management. The hyperactive subtype is characterized by prominent agitation, restlessness, and heightened sympathetic activity, often accompanied by hallucinations, delusions, and combative or uncooperative behavior.[1] Patients may exhibit hypervigilance, rapid speech, and irritability, which can lead to increased risks of injury to themselves or others.[20]In contrast, the hypoactive subtype presents with reduced psychomotor activity, including apathy, slowed responses, quiet withdrawal, and increased somnolence or lethargy.[1] Individuals often appear disengaged, with decreased alertness and responsiveness, making this form subtler and less disruptive than hyperactive delirium.[20] Symptoms such as drowsiness and reduced interaction can mimic fatigue, leading to frequent misdiagnosis as depression.[21]The mixed subtype involves fluctuating features, alternating between periods of agitation and lethargy over short intervals, sometimes within hours.[1] This variability complicates consistent symptom assessment, as patients may shift from restless combativeness to withdrawn sedation.[20]Clinical challenges in subtype recognition are significant, particularly for hypoactive delirium, which is often underdetected due to its inconspicuous nature. Studies indicate that up to 60% of delirium cases overall go unrecognized, with hypoactive forms disproportionately affected because they lack overt behavioral disturbances.[1] Recent 2025 research further emphasizes this issue, highlighting the underdetection of hypoactive delirium in hospitalized older adults, where subtle presentations delay intervention and worsen outcomes.[22]
Causes and Risk Factors
Predisposing Factors
Advanced age, particularly over 65 years, is one of the most consistently identified predisposing factors for delirium, appearing in numerous studies across various clinical settings.[23] This demographic vulnerability stems from age-related declines in brain reserve and physiological resilience, increasing susceptibility to cognitive disruptions.[23]Pre-existing cognitive impairment, such as mild cognitive impairment or early-stage dementia, significantly heightens the risk of delirium by reducing the brain's capacity to maintain attention and adapt to stressors.[23] Comorbid conditions further compound this vulnerability; frailty, characterized by diminished physical strength and endurance, is associated with higher delirium incidence in hospitalized older adults.[23] Sensory deficits, including vision and hearing loss, impair environmental awareness and communication, thereby elevating delirium risk, as evidenced in multisite prevalence studies of hospitalized patients.[24]Polypharmacy, especially involving anticholinergic agents and benzodiazepines, contributes to baseline vulnerability through cumulative effects on neurotransmitter systems and cognitive function.[23]Cumulative burden models help quantify these vulnerabilities; the Delirium Risk Index (DRI), a comorbidity-based tool, predicts postoperative delirium by integrating factors like age, cognitive status, and chronic illnesses, demonstrating strong validity in large administrative datasets.[25] Such indices enable clinicians to stratify risk and prioritize interventions for at-risk individuals.[25]
Precipitating Factors
Precipitating factors for delirium refer to acute insults or events that trigger the onset of delirium in individuals who may already have underlying vulnerabilities. These factors are often modifiable and identifiable in clinical settings, particularly among hospitalized older adults, where delirium incidence can reach 20-50%.[7]Medical precipitating factors commonly include infections such as urinary tract infections (UTIs) and pneumonia, which provoke systemic inflammation and cerebral effects leading to delirium. Metabolic disturbances, including electrolyte imbalances like hyponatremia or hypernatremia, and hypoxia from respiratory failure, further exacerbate brain dysfunction by altering neuronal signaling and oxygen delivery. Surgical procedures, especially cardiac surgery and orthopedic interventions like hip fracture repair, are significant triggers due to the stress of anesthesia, blood loss, and postoperative inflammation, with studies showing delirium rates up to 50% following such operations.[26][17][27]Iatrogenic factors arise from medical interventions and include medication side effects, particularly from opioids and sedatives like benzodiazepines, which depress central nervous system function and impair cognition. Anesthesia during surgery contributes through transient neurotoxicity, while immobilization from physical restraints or bed rest promotes deconditioning and sensory deprivation, increasing delirium risk by up to twofold in affected patients. Urinary catheterization, often used in hospitalized individuals, is another iatrogenic trigger linked to infection and discomfort.[26][7][10]Environmental precipitants involve disruptions in the hospital or intensive care unit (ICU) setting, such as sleep deprivation caused by noise, frequent monitoring, or artificial lighting, which disrupts circadian rhythms and heightens vulnerability to delirium. ICU environments, characterized by sensory overload from alarms and monitors alongside isolation, are particularly conducive, with delirium occurring in 60-80% of ICU patients exposed to these conditions.[26][7][10]Delirium frequently arises from multiple precipitating factors simultaneously in hospitalized older adults, which can overwhelm cerebral reserve.[26][7] As of 2025, COVID-19 infection has been associated with increased risk of delirium in hospitalized patients, particularly older adults.[28]
Delirium involves complex neurotransmitter imbalances, particularly a reduction in acetylcholine activity coupled with excess dopamine, which disrupt normal brain function. The cholinergic hypothesis posits that delirium arises from deficient cholinergic transmission, as evidenced by the precipitation of delirium symptoms through anticholinergic agents that block muscarinic receptors.[29] This model is supported by observations that anticholinergic drugs, such as certain antihistamines and antipsychotics, induce delirium-like states by inhibiting acetylcholine release and signaling in key brain regions.[29] Conversely, dopamine excess, often relative to cholinergic deficits, contributes to hyperactive features of delirium, with elevated dopaminergic activity in mesolimbic pathways exacerbating attentional and behavioral disturbances. These imbalances interact dynamically, where dopamine hyperactivity may further suppress cholinergic tone, forming a core pathophysiological loop.Inflammatory pathways play a central role in delirium by promoting neuroinflammation through cytokine release, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), which are markedly elevated in affected individuals.[30] These pro-inflammatory cytokines, released during systemic insults like infections or surgery, cross or disrupt the blood-brain barrier (BBB), allowing peripheral immune signals to infiltrate the central nervous system and trigger microglial activation.[30] BBB disruption, evidenced by increased permeability markers such as S100B and matrix metalloproteinases, facilitates this process, leading to neuronal hyperexcitability and synaptic dysfunction.[31] The neuroinflammatory hypothesis underscores how sustained cytokine signaling impairs cognitive networks, with IL-6 levels correlating with delirium severity in clinical cohorts.[32]Delirium manifests as a disruption in large-scale brain networks, particularly frontal-subcortical circuits that underpin attention and executive function. These circuits, connecting prefrontal cortex to basal ganglia and thalamus, exhibit reduced connectivity and integration during delirious states, as shown in functional MRI studies revealing decreased network efficiency.[33] This disintegration impairs sustained attention, a hallmark deficit, by decoupling thalamocortical loops essential for arousal and cognitive control.[33]Electroencephalography further supports this, demonstrating global slowing and loss of alpha rhythm coherence, indicative of widespread circuit failure.[33]The stress response in delirium involves hypothalamic-pituitary-adrenal (HPA) axis dysregulation, which amplifies vulnerability through excessive glucocorticoid release and subsequent oxidative stress. Aberrant HPA activation, often triggered by acute illness, leads to cortisol surges that exceed adaptive thresholds, promoting neuronal damage via glucocorticoid receptor-mediated pathways in the hippocampus and prefrontal cortex.[34] This dysregulation heightens oxidative stress by overwhelming antioxidant defenses, resulting in reactive oxygen species accumulation that damages lipids, proteins, and DNA in vulnerable neurons.[34] Consequently, increased neuronal damage contributes to transient but profound synaptic loss, exacerbating the acute brain dysfunction characteristic of delirium.[34]
Diagnostic Biomarkers
Diagnostic biomarkers for delirium encompass a range of neuroimaging, cerebrospinal fluid (CSF), neurophysiological, and neuropathological approaches that provide empirical insights into its underlying pathophysiology. These markers help identify disruptions in brainfunction and structure associated with the disorder, though their clinical utility remains investigational pending larger validation studies.[35]In neuroimaging, electroencephalography (EEG) commonly reveals diffuse slowing of background rhythms, characterized by increased delta and theta activity, which correlates with delirium severity and distinguishes it from other cognitive impairments.[35][36]Functional magnetic resonance imaging (fMRI) studies demonstrate thalamocortical dysconnectivity, with reduced connectivity in attention and arousal networks during resting-state scans in delirious patients compared to controls.[37][38]Cerebrospinal fluid analysis has identified elevated levels of tau protein, indicative of axonal injury, in patients with persistent or incident delirium, particularly those with comorbid Alzheimer's disease pathology.[39] Reduced β-amyloid (Aβ42) concentrations in CSF are also observed, potentially reflecting altered amyloid clearance mechanisms during acute brain stress in delirium. Inflammatory markers such as S100B, a calcium-binding protein released from astrocytes, are elevated in CSF of individuals developing delirium, especially in postoperative or critically ill settings, suggesting a role for neuroinflammation.[40]Neurophysiological assessments, including quantitative EEG (qEEG), quantify spectral power changes such as increased low-frequency (delta/theta) power and decreased alpha power, enabling prediction of postoperative delirium with high sensitivity in cardiac surgery patients.[41] Event-related potentials (ERPs), particularly the P300 component, show prolonged latencies and reduced amplitudes in delirious individuals, reflecting underlying attention and cognitive processing deficits.[42]Neuropathological examinations from postmortem studies of intensive care unit patients with prior delirium frequently reveal hypoxic-ischemic damage, including neuronal loss and gliosis in the hippocampus, pons, and striatum, which may contribute to the acute cognitive disruptions observed clinically.[43] Microglial activation, evidenced by increased expression of inflammatory markers like interleukin-6 (IL-6), is prominent in brain tissue from delirious elderly patients, indicating a sustained neuroinflammatory response.[44] Animal models, such as lipopolysaccharide (LPS)-induced systemic inflammation in aged rodents, replicate cytokine-driven cognitive deficits akin to delirium, with elevated IL-6 and tumor necrosis factor-alpha (TNF-α) impairing working memory and hippocampal function.[45][46]Emerging blood-based biomarkers as of 2025 include neurofilament light chain (NfL), a marker of neuronal injury, and glial fibrillary acidic protein (GFAP), a marker of astrocytic damage, which show elevated plasma levels in critically ill patients at risk for delirium, correlating with duration and severity while offering a non-invasive alternative to CSF analysis for prediction and monitoring.[47][48] These findings from high-impact cohort and autopsy studies underscore the potential of multimodal biomarkers to elucidate delirium's neurobiological signatures.
Diagnosis
Diagnostic Criteria and Tools
The diagnosis of delirium relies on standardized criteria outlined in major classification systems, which emphasize acute disturbances in attention, awareness, and cognition attributable to underlying medical causes. According to the DSM-5-TR, delirium is diagnosed when there is a disturbance in attention (reduced ability to direct, focus, sustain, and shift attention) and awareness (reduced orientation to the environment), developing over a short period (hours to days) as a change from baseline and fluctuating in severity; this must be accompanied by an additional cognitive disturbance (e.g., memorydeficit, disorientation, or perceptual changes) not better explained by another neurocognitive disorder or severely reduced arousal, with evidence of a direct physiological consequence from a medical condition, substance, or toxin.[5] Similarly, the ICD-11 defines delirium as a disturbance in attention and awareness that develops rapidly (hours to days) as a change from baseline, accompanied by cognitive changes, not better explained by another mental disorder or coma, and attributable to a medical condition, substance intoxication/withdrawal, or toxin exposure.In clinical practice, screening tools operationalize these criteria for efficient identification, particularly in high-risk settings. The Confusion Assessment Method (CAM), a bedside instrument requiring about 5 minutes, assesses four core features—acute onset and fluctuating course, inattention, disorganized thinking, and altered level of consciousness—with delirium present if features 1 and 2 are met plus either 3 or 4; it demonstrates high validity, with sensitivity of 94-100% and specificity of 90-95% against psychiatrist assessments in validation studies.[49] The 3D-CAM, a structured 3-minute diagnostic interview version of the CAM, incorporates direct patient testing for inattention and confirms the other features, achieving pooled sensitivity of 92% and specificity of 95% across diverse hospital settings.[50] For intensive care units, the Intensive Care Delirium Screening Checklist (ICDSC), an 8-item nurse-led tool evaluating symptoms like inattention and disorientation over an 8-24 hour period (scoring ≥4 indicates delirium), shows good reliability and validity, with sensitivity ranging from 74-100% and specificity 75-82% in critically ill patients.[51]Despite these tools' strengths, gaps persist, particularly in detecting hypoactive delirium, where patients exhibit lethargy and withdrawal rather than agitation; the CAM, for instance, has notably lower sensitivity (around 31-50%) for this subtype compared to hyperactive forms, potentially leading to underdiagnosis.[52] Recent advances as of 2025 include the Family Confusion Assessment Method (FAM-CAM), a validated 11-item tool for family or caregiver administration to detect postoperative delirium symptoms, which in a multicenter study identified changes in 22.4% of cases (versus 18.8% researcher-assessed incidence), though with variable sensitivity highlighting needs for integration with clinical judgment.[53] Additionally, AI-assisted screening has emerged for rapid emergency department use, with models analyzing electronic health records to predict delirium risk, quadrupling detection rates in hospitalized patients and improving outcomes through early intervention alerts.[54]
Settings and Challenges
Delirium diagnosis occurs across diverse clinical settings, including general hospital wards and post-surgical units, where underrecognition remains prevalent. In hospitalized older adults, delirium is underrecognized in up to 70% of cases, affecting approximately one-third of general medical inpatients aged 70 years or older. Post-surgical units face similar issues, with delirium incidence ranging from 15% to 25% following major elective surgery and escalating to 50% after high-risk procedures, often due to the acute physiological stress of surgery complicating symptom identification.[17]In intensive care units (ICUs), delirium prevalence is markedly higher, impacting 60% to 80% of mechanically ventilated patients. Sedation practices, which are routine in ICUs to facilitate mechanical ventilation, frequently obscure or exacerbate delirium symptoms, such as altered attention and cognition, thereby hindering timely diagnosis. Mechanical ventilation itself poses additional challenges by limiting patient interaction and verbal communication, further delaying recognition in this high-risk population.[55]Emergency departments (EDs) present unique diagnostic demands due to delirium's rapid onset amid chaotic environments and time pressures. The condition affects up to 38% of older adults in EDs, yet screening for geriatric patients remains inconsistent, with 2025 studies revealing substantial gaps in routine evaluation that contribute to underdiagnosis. These gaps stem from overburdened staff and the need for expedited assessments, underscoring the requirement for streamlined protocols in this fast-paced setting.[56][57]Several barriers impede accurate delirium detection across these settings, including the fluctuating course of symptoms, which can result in assessments capturing only baseline mental status and missing acute episodes. Communication difficulties, especially among non-English-speaking patients, exacerbate underdiagnosis due to inadequate access to interpreters, limiting the ability to evaluate cognitive changes effectively. Variability in rater training among healthcare providers also leads to inconsistent application of assessment methods, reducing overall diagnostic reliability. Tools like the Confusion Assessment Method (CAM) have been adapted for ICU, ED, and other contexts to mitigate these obstacles.[58][59][60][49]
Differential Diagnosis
Delirium must be differentiated from several conditions that present with altered mental status, as misdiagnosis can delay treatment of underlying causes. Primary differentials include dementia, depression, and psychosis, each sharing overlapping cognitive or behavioral features but differing in onset, course, and etiology. A thorough clinical history, physical examination, and targeted investigations are essential to distinguish delirium's acute, fluctuating nature from these chronic or primary psychiatric syndromes.[1]Dementia, particularly Alzheimer's disease, is a common mimic due to shared cognitive impairments such as memory loss and disorientation, but delirium features an abrupt onset over hours to days with prominent inattention and fluctuating alertness, whereas dementia shows a gradual, progressive decline over months to years without acute alterations in consciousness. Preexisting dementia is associated with a 3- to 4-fold increased risk of delirium in hospitalized patients, with incidence rates up to 20-50% in this group, often complicating differentiation, yet delirium's reversibility upon addressing precipitants like infection or medication toxicity provides a key clue. Depression may resemble delirium through pseudodementia, with affective symptoms like apathy mimicking cognitive deficits, but lacks the rapid fluctuations and altered awareness; instead, it presents with insidious onset, intact consciousness, and predominant mood disturbances such as sadness or anhedonia. Psychosis, as in schizophrenia, can overlap with delirium's hallucinations or delusions, but primary psychosis involves persistent, systematized perceptual disturbances without an identifiable medical trigger, contrasting delirium's secondary, environmentally influenced, and often visual hallucinations tied to acute physiological insults.[61][62][1]Other medical conditions mimicking delirium include stroke, nonconvulsive status epilepticus, and substance intoxication or withdrawal. Stroke typically presents with focal neurological deficits absent in uncomplicated delirium, though neuroimaging is warranted if asymmetry or sudden onset suggests vascular etiology. Nonconvulsive seizures may cause fluctuating confusion without overt motor activity, distinguishable via electroencephalography showing epileptiform activity. Substance-related states, such as alcoholwithdrawal or opioid intoxication, produce acute behavioral changes but are identified through toxicology screening and history of exposure. Hypoactive delirium, characterized by lethargy and reduced responsiveness, can be confused with akinetic mutism—a rare syndrome of profound immobility and muteness from frontal-subcortical lesions—but the latter lacks the attentional fluctuations and responds differently to stimuli, often requiring advanced imaging for confirmation.[1][62]The diagnostic approach emphasizes serial cognitive assessments to capture delirium's hallmark fluctuations, often worsening at night, using tools like the Confusion Assessment Method (CAM) with 94-100% sensitivity and 90-95% specificity. Collateral history from caregivers establishes baseline function, while medical workup—including laboratory tests for metabolic derangements, infection markers, and electrolytes, plus selective imaging (e.g., CT head yielding ~7% positive findings without focal signs)—rules out organic causes. This multifaceted strategy ensures exclusion of mimics while confirming delirium's acute, multifactorial basis.[1][61]
Non-pharmacological strategies form the cornerstone of delirium prevention, emphasizing behavioral, environmental, and multicomponent interventions to mitigate risk in vulnerable populations such as hospitalized older adults. These approaches target modifiable factors like cognitive disorientation, sleep disruption, and immobility, aligning with evidence-based guidelines that prioritize non-drug methods as first-line interventions.[18]The ABCDEF bundle, developed by the Society of Critical Care Medicine, provides a structured framework for preventing delirium in intensive care settings. It encompasses: Assessment and management of pain to address discomfort that can precipitate confusion; Both spontaneous awakening trials and spontaneous breathing trials to minimize sedation effects; Choice of analgesia and sedation strategies that preserve patientorientation; Delirium assessment and management through regular screening; Early mobility and exercise to counteract immobility-related deconditioning; and Family engagement and empowerment to enhance reorientation and emotional support. Implementation of this bundle has been shown to reduce delirium incidence by coordinating interdisciplinary care.[63][64]Environmental modifications play a key role in maintaining circadian rhythms and reducing sensory overload, which can exacerbate delirium vulnerability. Strategies include providing orientation aids such as clocks, calendars, and personal family photos to reinforce time, place, and identity; minimizing noise levels through quiet hours and sound-absorbing materials; and promoting exposure to natural light to support sleep-wake cycles. These interventions foster a calming, familiar atmosphere that helps prevent disorientation in acute care environments.[65]Multicomponent interventions integrate hydration, nutrition, and sensory support to address physiological and perceptual deficits holistically. Ensuring adequate fluid intake prevents dehydration-induced cognitive impairment, while balanced nutrition supports metabolic stability; sensory aids like glasses, hearing devices, or mobility assistance counteract deficits that contribute to confusion. The 2025 American Psychiatric Association guideline highlights that adherence to such multicomponent protocols can prevent approximately 40% of delirium cases in at-risk patients.[18]Randomized controlled trials (RCTs) demonstrate the efficacy of these strategies, particularly in elderly surgical patients, where multicomponent non-pharmacological interventions have achieved 30-50% reductions in delirium risk compared to standard care. For instance, a meta-analysis of 11 studies reported over 50% odds reduction in delirium incidence with targeted protocols, underscoring their impact on postoperative outcomes without relying on medications.[66][67]
Pharmacological Approaches
Pharmacological approaches to delirium prevention focus on targeted prophylactic agents in high-risk populations, alongside strategies to minimize medications that exacerbate risk, particularly in surgical and intensive care settings. These interventions aim to mitigate precipitating factors such as sedation-related disruptions, but evidence supports their use selectively rather than universally due to potential adverse effects.[68]Low-dose haloperidol has been investigated as a prophylactic agent for postoperative delirium in elderly surgical patients at high risk, such as those undergoing major orthopedic or cardiac procedures. However, meta-analyses indicate mixed results, with some older studies showing benefit for antipsychotics overall (RR 0.50; 95% CI: 0.34–0.73) but more recent evidence, including for low-dose haloperidol (typically 0.5–1 mg every 8–12 hours), demonstrating no significant reduction in incidence (e.g., OR 0.72; 95% CI: 0.42–1.23). This is attributed to its antipsychotic properties, but monitoring for cardiac effects like QT prolongation is essential, and routine use is not recommended.[68][69]Melatonin supplementation targets sleep-wake cycle dysregulation, a common vulnerability in hospitalized patients prone to delirium. Administered at doses of 0.5–3 mg nightly, melatonin has shown promise in reducing delirium incidence in older adults, particularly in perioperative and medical wards, by improving sleep quality and stabilizing circadian rhythms. A systematic review of trials reported a significant reduction in delirium rates (risk ratio 0.51; 95% CI: 0.30–0.85), with benefits most evident in non-ventilated patients.[70] However, results are inconsistent across studies, with some finding no effect on delirium severity despite prophylaxis success.[71]Avoidance of deliriogenic medications forms a cornerstone of pharmacological prevention, emphasizing minimization of benzodiazepines and opioids, which are associated with prolonged delirium episodes in intensive care and postoperative settings. Clinical guidelines recommend against initiating benzodiazepines in at-risk patients and advocate dose reduction or discontinuation where possible, as their use correlates with increased delirium duration (hazard ratio for resolution delay).[72] Similarly, opioids should be used judiciously, with non-opioid alternatives preferred, given their link to cognitive disruption independent of paincontrol.[73] In ICU environments, dexmedetomidine offers a safer alternative for sedation, providing lighter, more natural sleep without respiratory depression. Meta-analyses demonstrate that dexmedetomidine infusion (0.2–0.7 μg/kg/hour) lowers delirium incidence by 20–30% compared to benzodiazepines (RR 0.75; 95% CI: 0.60–0.94), particularly in mechanically ventilated adults.[74][75]Major guidelines, including the 2025 American Psychiatric Association and those from the Society of Critical Care Medicine, do not endorse broad pharmacological prophylaxis for delirium due to limited net benefits and risks such as QT interval prolongation with antipsychotics, which can precipitate torsades de pointes in vulnerable patients. Recent meta-analyses show no significant prophylactic efficacy for haloperidol (RR 0.94; 95% CI: 0.77–1.16) in critically ill cohorts, alongside requirements for cardiac monitoring.[76][18] Emerging research, including AI-driven drug discovery frameworks integrating multi-omics data, is exploring novel anti-inflammatory agents to target neuroinflammation in delirium pathogenesis, with 2025 trials evaluating candidates like repurposed immunomodulators for high-risk prevention.[77] These approaches complement non-pharmacological strategies but require further validation to balance efficacy against side effects.[78]
Treatment
Non-Pharmacological Interventions
Non-pharmacological interventions form the cornerstone of delirium management, emphasizing supportive care to address underlying triggers and promote recovery without relying on medications as the primary approach. These strategies aim to restore orientation, enhance sensory input, and optimize environmental factors, often implemented by interdisciplinary teams including nurses, therapists, and family members. Evidence from systematic reviews supports their efficacy in reducing delirium severity and duration in hospitalized adults, particularly when delivered early in the episode.[79][80]Reorientation techniques involve providing frequent verbal cues about time, place, and person to counteract confusion, alongside placing familiar objects such as family photos or clocks in the patient's environment to anchor them to reality. Family involvement plays a key role, offering emotional support through visits and conversations that reinforce identity and reduce anxiety, which can exacerbate disorientation. These methods have demonstrated effectiveness in improving cognitive clarity, with studies showing decreased agitation when implemented consistently by bedside staff.[81][82][80]Early mobility interventions, such as physical therapy sessions tailored to the patient's condition, encourage ambulation or range-of-motion exercises to combat immobility-induced cognitive decline. Concurrently, optimizing sensory function by ensuring access to glasses and hearing aids minimizes isolation and perceptual distortions that fuel delirium symptoms. These combined approaches have been linked to shorter hospital stays and lower complication rates in older adults.[79][83]Sleep hygiene protocols prioritize scheduled rest periods during the day and minimizing nighttime disruptions, such as clustering nursing interventions and dimming lights to preserve the natural sleep-wake cycle. Multicomponent programs like the Hospital Elder Life Program (HELP) integrate these elements with reorientation and mobility support, delivering targeted interventions by trained volunteers to at-risk patients. HELP has been shown to reduce delirium incidence by up to 40% and improve functional outcomes in geriatric wards.[80][84][85]Recent advancements as of 2025 highlight behavioral strategies adapted for patients with serious illnesses, including music therapy using slow-tempo personalized playlists to alleviate agitation and lower delirium risk by approximately 50% in intensive care settings. These interventions complement pharmacological options when needed, focusing on holistic symptom relief through non-invasive means.[86][87]
Pharmacological Management
The primary approach to pharmacological management of established delirium involves identifying and treating underlying precipitants, such as infections with appropriate antibiotics or metabolic disturbances with targeted corrections.[88] This step is essential, as addressing reversible causes can resolve delirium without additional symptomatic therapy.[18]For symptomatic control, particularly in cases of hyperactive delirium with severe agitation or distress posing risk to the patient or others, low-dose antipsychotics may be used judiciously after nonpharmacological measures fail. Haloperidol, administered at 0.5-1 mg orally, intravenously, or subcutaneously every 6-8 hours as needed, is a first-line option due to its rapid onset and availability in multiple routes, though evidence for its efficacy in reducing delirium duration remains limited.[89][88] Atypical antipsychotics like quetiapine serve as alternatives, starting at 25 mg orally once or twice daily and titrated up to 50-100 mg as tolerated, offering fewer extrapyramidal side effects compared to haloperidol.[90][88] However, 2025 guidelines from the American Psychiatric Association strongly caution against routine use of antipsychotics for delirium treatment, citing insufficient evidence of benefit and an associated increased mortality risk from meta-analyses of clinical trials.[18][91]Benzodiazepines are generally avoided due to their potential to exacerbate delirium, except in specific cases like alcohol or benzodiazepine withdrawal, where short-acting agents such as lorazepam (0.5-1 mg as needed) may be indicated to prevent seizures.[88][18] In intensive care unit settings, particularly for mechanically ventilated patients, dexmedetomidine infusion (starting at 0.2-0.7 mcg/kg/hour) is recommended over benzodiazepines for sedation to minimize delirium risk, as supported by Society of Critical Care Medicine guidelines.[92][93]Ongoing monitoring is critical, including electrocardiography to assess for QTc prolongation with antipsychotics like haloperidol, and serial evaluations using tools such as the Confusion Assessment Method (CAM) to gauge treatment efficacy and guide de-escalation.[88] All pharmacological interventions should be reviewed daily and discontinued as soon as clinically appropriate to mitigate adverse effects.[18]
Prognosis and Outcomes
Short-Term Prognosis
In the short term, delirium often resolves with prompt identification and treatment of underlying causes, such as infections or metabolic imbalances, though poor outcomes (death, long-term institutionalization, or functional decline) occur in approximately 69% of elderly patients, implying good recovery in about 31%.[94] However, persistence occurs in a notable subset, particularly in intensive care unit (ICU) settings, where up to 45% of cases remain unresolved at hospital discharge, contributing to extended hospital stays.[17]Short-term complications of delirium include heightened risks of physical injuries and healthcare resource utilization. Patients with delirium experience an increased incidence of falls, with risk ratios up to sixfold compared to non-delirious individuals, often due to impaired attention and motor coordination.[95] Additionally, delirium is associated with prolonged mechanical ventilation duration and higher 30-day mortality rates, conferring a 2- to 3-fold elevated risk independent of baseline illness severity.[96][10]Prognostic factors influencing short-term outcomes include delirium subtype and episode duration. The hypoactive subtype, characterized by lethargy and reduced responsiveness, is linked to poorer resolution and higher mortality compared to hyperactive or mixed forms.[97] Longer episodes are predictive of incomplete short-term recovery, with increased likelihood of ongoing symptoms and functional impairment at discharge.[98]In ICU patients, delirium contributes to post-delirium weakness syndrome among survivors, manifesting as profound muscle weakness and delayed physical rehabilitation in the immediate post-acute phase.[99] This syndrome exacerbates ventilation dependence and mobility limitations, affecting a substantial portion of mechanically ventilated patients who develop delirium.[10]
Long-Term Consequences
Delirium episodes in older adults are associated with accelerated progression of underlying dementia. In individuals with Alzheimer's disease, hospitalization-related delirium leads to a 1.7- to 2.2-fold faster rate of cognitive decline in the year following the episode and sustains this acceleration over up to five years, independent of baseline dementia severity, comorbidities, and demographics.[100] Furthermore, delirium independently elevates the risk of incident dementia, including Alzheimer's disease, by several-fold; population-based cohort studies report an odds ratio of 8.7 (95% CI 2.1-35) for new-onset dementia in the oldest-old following a delirium event.[101]Long-term functional consequences include heightened dependency in activities of daily living (ADLs) and increased likelihood of institutionalization. Delirium predicts persistent ADL impairment at follow-ups ranging from hospital discharge to two years, with affected patients showing significantly greater loss of independence compared to those without delirium.[102] Among ICU survivors, delirium contributes to up to 50% prevalence of enduring cognitive dysfunction and PTSD symptoms, exacerbating overall functional decline. Prognosis is generally better in younger adults without comorbidities, with higher rates of full recovery.[103][1] The odds of nursing home placement rise substantially post-delirium, with adjusted hazard ratios indicating a 2- to 3.5-fold increased risk after accounting for confounders like age and illness severity.[104]Mortality remains elevated well beyond the acute phase, with 1-year post-discharge survival rates for delirium patients around 65% versus 85% in non-delirium counterparts, reflecting a 62% increased mortality risk.[105] A 2025 systematic review confirms this, documenting a 2.73-fold higher 1-year mortality odds ratio (95% CI 2.07-3.60) in older inpatients with delirium.[106] Recent 2025 analyses further link delirium to adverse frailty trajectories, particularly in post-COVID cohorts, where it correlates with sustained cognitive vulnerability and altered long-term physical resilience patterns without uniformly worsening frailty scores.[107]Subtype-specific effects highlight the hypoactive form's prognostic severity, as it predicts greater residual cognitive impairment and functional residue compared to hyperactive delirium, often due to underrecognition and delayed intervention.[17] In critically ill patients, hypoactive delirium duration associates with steeper long-term cognitive trajectories, independent of motoric subtype variations.[108]
Epidemiology
Prevalence and Incidence
Delirium affects a significant proportion of hospitalized adults, with prevalence rates ranging from 10% to 30% across general medical and surgical wards.[109] Recent meta-analyses confirm a pooled prevalence of 23.6% in medically hospitalized older patients.[110] In older adults, these rates are notably higher, reaching 29% to 64% in hospitalized populations.[111] Among critically ill patients in intensive care units (ICUs), the pooled incidence of delirium is approximately 28.8%, though it can exceed 80% in high-risk subgroups such as those undergoing major surgery.[112][113]Postoperative delirium is particularly common in elderly patients, with incidence rates of 15% to 50% following noncardiac surgery and up to 87% in some surgical cohorts.[113][114] In acute care settings, the incidence of new delirium cases typically ranges from 20 to 50 episodes per 1000 person-days, varying by patient acuity and unit type.[115][116] Global point prevalence surveys indicate delirium occurs in about 18% of hospitalized patients, with higher rates in low-resource settings.[117]Prevalence trends are increasing worldwide, driven by aging populations; by 2030, one in six people globally will be aged 60 or older, amplifying delirium risk in healthcare systems.[118] In high-income countries, annual delirium cases are projected to rise substantially, reflecting demographic shifts and improved survival in vulnerable groups. Variations include elevated rates in pediatrics after cardiac surgery (21% to 59%) and up to 88% in end-of-life palliative care settings.[119][120]
Demographic Patterns
Delirium exhibits a marked increase in prevalence with advancing age, showing an exponential rise particularly after 65 years. In hospitalized settings, rates reach approximately 23% among older adults compared to around 6% in those under 65, reflecting the heightened vulnerability of aging physiological systems to precipitating factors.[17] In the community, delirium remains uncommon in younger populations but escalates to 14% or higher in individuals over 85.[121] Among pediatric patients, delirium is rare outside of critical illness contexts, though it affects up to 25% of children in pediatric intensive care units, often linked to mechanical ventilation and sedation.[122]Regarding sex, studies have shown mixed results, with no consistent independent association, though a slight predominance is sometimes observed among females in elderly cohorts, largely attributed to women's greater average longevity and higher representation in older age groups.[123] This pattern holds in hospital-based studies of older adults, where females comprise over 55% of those screened positive for delirium.[124]Ethnic and racial disparities contribute to uneven distribution, with higher delirium rates among minority groups, such as Black patients exhibiting an odds ratio of 1.5 compared to non-Hispanic White patients. This elevated risk is associated with systemic care disparities, higher comorbidity burdens, and socioeconomic factors that exacerbate vulnerability during acute illness.[125] Similar trends appear in Hispanic and other non-White populations, underscoring the role of structural inequities in delirium outcomes.[124]Global patterns reveal higher documented rates in some low-resource settings, such as approximately 34% in African hospitals, where resource constraints and limited routine screening may contribute to challenges in recognition and management despite aging populations.[126] The COVID-19 pandemic further amplified these demographic patterns, disproportionately increasing delirium incidence in vulnerable groups such as older adults, ethnic minorities, and those with preexisting comorbidities, with rates up to 65% in severe cases.[127]
History and Society
Historical Perspectives
The understanding of delirium traces back to ancient civilizations, where it was often intertwined with concepts of fever and inflammation of the mind. In ancient Greece, Hippocrates around 500 BC described what is now recognized as delirium under the term "phrenitis," portraying it as an acute mental disturbance caused by braininflammation, typically associated with fever or poisoning.[128] This condition was characterized by symptoms such as confusion, agitation, and sensory disturbances, distinguishing it from chronic mental states.[129] In Roman medicine, phrenitis continued to be viewed similarly, but broader cultural perspectives sometimes attributed such acute mental alterations to supernatural causes, including divine punishment or demonic influences, reflecting the era's blend of empirical observation and religious beliefs.[130]By the 19th century, medical conceptualizations of delirium evolved toward more specific etiologies, particularly linking it to infections, fevers, and intoxications. Physicians observed delirium as a common complication of systemic illnesses like typhus or pneumonia, often termed "brain fever" to denote its association with cerebral inflammation during febrile states.[131] A notable advancement was the recognition of alcohol withdrawal as a distinct trigger; in 1813, British physician Thomas Sutton coined the term "delirium tremens" to describe the severe confusional state accompanied by tremors, hallucinations, and autonomic hyperactivity in chronic alcohol users undergoing abstinence.[132] This period also saw efforts to redefine delirium phenomenologically, emphasizing clouded consciousness and confusion as core features, separate from mere agitation.[133]In the 20th century, psychiatric nosology formalized delirium's place in diagnostic systems, evolving from vague "acute brain syndromes" to a distinct entity. Prior to the 1980s, American classifications like the DSM-I (1952) and DSM-II (1968) grouped it under broad "acute brain syndrome" or organic reactions, often conflating it with dementia or other cognitive impairments.[130] The DSM-III (1980) marked a pivotal shift by introducing "delirium" as a specific diagnosis within organic mental disorders, highlighting its acute onset, fluctuating course, and reversibility, while clearly differentiating it from dementia's chronic progression—a distinction reinforced in subsequent editions.[134] Internationally, the ICD-11 (2019) refined delirium criteria to include diminished arousal and disorientation, aligning with DSM updates while emphasizing global applicability.[135] This recognition underscored delirium's medical rather than purely psychiatric nature, prompting interdisciplinary attention.Key milestones in recent decades have refined delirium's classification and management focus. The DSM-5 (2013) incorporated subtype specifiers—hyperactive, hypoactive, and mixed—based on psychomotor features, along with severity ratings, to better capture its heterogeneous presentations and guide clinical assessment.[136] More recently, the American Psychiatric Association's 2025 Practice Guideline for the Prevention and Treatment of Delirium emphasized proactive strategies, such as multicomponent interventions in at-risk populations, signaling a paradigm shift toward prevention over reactive treatment in healthcare settings.[137]
Societal Impact and Costs
Delirium imposes a substantial economic burden on healthcare systems, with estimates indicating an annual cost of approximately $182 billion in the United States as of 2025, primarily attributable to extended hospital lengths of stay and increased readmission rates.[138] Delirium typically prolongs hospital stays by 3 to 5 days on average, contributing to higher resource utilization and complicating patient discharge planning.[139] Additionally, it elevates the risk of readmissions within 30 days, further amplifying costs through repeated hospitalizations and post-acute care needs.[140]Culturally, delirium often carries stigma, particularly when conflated with "sundowning" in elderly care settings, where symptoms like evening agitation are dismissed as inevitable dementia behaviors rather than treatable acute conditions.[141] This misattribution fosters underrecognition, with delirium receiving far less media and public attention compared to dementia, despite its reversibility and distinct clinical profile.[142]On the policy front, 2025 has seen initiatives such as the American Psychiatric Association's updated practice guideline for delirium management, emphasizing integration into geriatric care protocols to standardize screening and intervention.[137] However, significant disparities persist in low-resource settings, where limited access to multidisciplinary teams and diagnostic tools exacerbates underdiagnosis and poorer outcomes among vulnerable populations.[124]From a public health perspective, delirium places a heavy burden on family caregivers, who report heightened emotional distress, anxiety, and role strain due to managing fluctuating symptoms and navigating healthcare systems.[143] This challenge is compounded by global aging trends, with the population aged 60 and older projected to double by 2050, potentially intensifying delirium's societal impact as healthcare demands rise.[118]