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Place cell

A place cell is a type of neuron found primarily in the hippocampus of the mammalian brain that selectively fires action potentials when an animal is located within a specific region of its environment, known as the place field, thereby contributing to the formation of an internal cognitive map for spatial navigation and memory encoding.^[1] These cells were first identified in 1971 by John O'Keefe and Jonathan Dostrovsky through single-unit recordings in the CA1 region of the hippocampus in freely moving rats, where they observed that certain neurons discharged robustly only when the animal occupied particular positions in a test environment. Place cells exhibit stable but flexible firing patterns, with place fields typically spanning 30-60 cm in rodents and varying in size and shape depending on the environmental context, such as the size of the arena or the presence of landmarks.^[2] The activity of place cells is modulated by both external sensory cues, like visual or olfactory landmarks, and internal signals, including the animal's movement and head direction, allowing the neural representation to update dynamically as the animal explores.^[1] In larger environments, individual place cells can develop multiple place fields, but collectively, populations of place cells provide a comprehensive, allocentric map of space that is independent of the animal's egocentric perspective.^[2] When the environment changes—such as altering the shape of a testing arena or switching between distinct rooms—place cell firing remaps rapidly, either partially or completely, reflecting the brain's ability to form distinct representations for different contexts.^[1] Beyond spatial coding, place cells play a crucial role in episodic memory by replaying sequences of experiences during rest or sleep through sharp-wave ripples, a high-frequency oscillation in the hippocampus that consolidates learned spatial trajectories and supports long-term memory storage.^[2] They integrate inputs from other specialized cells in the hippocampal formation, such as grid cells in the entorhinal cortex—which provide a metric lattice for distance and direction—and border cells, which signal environmental boundaries, to generate a unified positioning system.^[3] Disruptions to place cell function, as seen in hippocampal lesions, impair spatial learning and navigation, underscoring their importance in behaviors from foraging to goal-directed decision-making across species, including humans as evidenced by neuroimaging studies.^[2]

Discovery and Background

Historical Discovery

Place cells were first identified in 1971 by John O'Keefe and Jonathan Dostrovsky through extracellular recordings from the hippocampus of freely moving rats, revealing that certain pyramidal neurons fired selectively when the animal was in specific locations within its environment.^[4] This discovery occurred serendipitously during studies of hippocampal responses to somatosensory stimuli, where the location-specific firing patterns emerged as a prominent feature independent of sensory inputs.^[1] In their seminal short communication published in Brain Research, O'Keefe and Dostrovsky described these "place-specific" units, proposing that they contributed to a spatial mapping function in the brain.^[5] Building on this initial evidence, O'Keefe and Lynn Nadel elaborated the theoretical implications in their 1978 book The Hippocampus as a Cognitive Map, positing that place cells formed the neural basis for an allocentric representation of space, akin to Edward Tolman's earlier concept of a cognitive map.^[6] The book integrated the place cell findings with broader hippocampal lesion studies, arguing that the hippocampus constructs and maintains internal spatial models essential for navigation and memory.^[7] However, the discovery faced initial skepticism within the neuroscience community, dominated by behaviorist paradigms that emphasized stimulus-response associations over cognitive representations, delaying widespread acceptance.^[1] Replication efforts were hampered by technological limitations in the 1970s, as chronic single-unit recordings in freely behaving animals required precise electrode implantation and behavioral tracking, which were rudimentary without advanced computing.^[8] It was not until the early 1980s, with improvements in microdrive technology and the introduction of video-based head-tracking systems, that more robust replications confirmed the stability and specificity of place cell activity, as demonstrated in studies using radial arm mazes.^[1] These advancements, including quantitative analyses by Bruce McNaughton and colleagues, solidified the role of place cells in spatial cognition.^[8] The foundational contributions of place cell research were recognized with the 2014 Nobel Prize in Physiology or Medicine, awarded to O'Keefe (shared with May-Britt Moser and Edvard I. Moser for their discovery of grid cells, a complementary spatial representation in the entorhinal cortex).^[9]

Relationship to Grid Cells and Other Spatial Neurons

Place cells in the hippocampus integrate spatial information from various entorhinal cortex neurons to form a cognitive map of the environment. A primary input comes from grid cells in the medial entorhinal cortex (MEC), which were discovered in 2005 and exhibit periodic firing patterns arranged in a hexagonal lattice across the navigated space. These grid cells provide a scalable, metric representation of location, with firing fields repeating at regular intervals that vary systematically across modules defined by spatial scale. The convergence of inputs from multiple grid cell modules onto individual place cells is believed to underlie the localized firing fields of place cells, enabling precise spatial coding.^[10] Head-direction cells, first identified in the postsubiculum, encode an animal's instantaneous directional heading independent of location and project to both the MEC and hippocampus. These cells maintain a consistent preferred firing direction, updated via path integration and stabilized by visual landmarks, and their activity modulates the directional selectivity observed in some hippocampal place cells, particularly in novel or asymmetric environments. In the entorhinal cortex, head-direction signals interact with grid cell firing to generate anisotropic patterns, further refining the directional components of place cell representations. Additional entorhinal inputs include border cells, which fire selectively near environmental boundaries such as walls or edges, comprising about 10% of MEC neurons and influencing the positioning and shape of place field peripheries. Object-vector cells in the MEC, which encode the allocentric distance and direction to nearby objects, provide place cells with object-centered spatial references, allowing adaptation to salient landmarks without relying solely on global geometry. These inputs collectively contribute to the robustness of place cell activity against environmental changes. Theoretical models, such as continuous attractor networks, propose that grid cell inputs to the hippocampus generate place fields through interference mechanisms, where the superposition of periodic grid patterns from different modules produces localized peaks resembling place cell firing. In these attractor-based frameworks, recurrent connectivity within the hippocampal network stabilizes the resulting representations, while entorhinal inputs drive the initial computation via excitatory projections. Such models explain how the combinatorial activity of grid, head-direction, border, and object-vector cells forms a unified spatial framework for place cells.

Core Properties

Place Fields

Place fields represent the core spatial tuning characteristic of place cells, defined as discrete regions within an environment where a place cell exhibits significantly elevated firing rates compared to surrounding areas. In rodents, these fields typically span 30-60 cm in diameter, with peak firing rates reaching 20-50 Hz that decline sharply outside the field boundaries.^[11] This selective activation allows place cells to encode specific locations, forming a sparse neural representation of space. The firing pattern of place cells demonstrates sparsity, with only 10-20% of cells active at any given location, ensuring efficient coverage of the environment without redundant overlap.^[12] Firing rate versus position typically follows Gaussian-like tuning curves, where the rate increases smoothly to a peak within the field and falls off symmetrically, providing a probabilistic map of spatial occupancy.^[13] In small arenas, place cells generally exhibit a single place field, but the number of fields per cell varies in larger environments, often increasing to multiple irregular fields that collectively tile space.^[13] A 2025 study revealed universal statistical properties governing field sizes, shapes, and arrangements across species and dimensionalities, explaining this variability through underlying Gaussian input statistics.^[13] Recent findings further indicate that, in familiar environments, all active pyramidal cells in the dorsal CA1 region function as place cells, challenging prior notions of a subset of specialized neurons.^[14] Place field properties are influenced by inputs from entorhinal grid cells, which provide a periodic metric structure that helps shape the spatial selectivity of hippocampal place cells.^[15]

Stability, Remapping, and Multiple Fields

Place cells exhibit remarkable stability in their firing patterns when the environment remains consistent. In familiar, fixed environments, the spatial firing fields of place cells show high correlation between repeated recording sessions, with mean maximum spatial correlations often exceeding 0.8, indicating reliable representation of location over short timescales such as within or across brief exposures.^[16] This stability persists even with minor manipulations that preserve overall environmental cues, such as rotating a prominent cue card or removing it temporarily, where fields rotate predictably or maintain their core properties without significant disruption.^[16] However, place cells demonstrate adaptability through remapping when environmental contexts change, a process that allows the hippocampal map to update in response to novelty. Subtle alterations, such as introducing barriers that bisect firing fields or modifying local cues without altering the overall shape, often induce partial remapping characterized by changes in firing rates within existing fields—termed rate remapping—while preserving field locations.^[16] In contrast, major changes like reshaping the environment (e.g., from a cylinder to a rectangle) trigger global remapping, where the majority of place cells exhibit entirely new firing patterns uncorrelated with prior sessions, effectively generating a distinct spatial code.^[16] Seminal studies from the 1990s, building on earlier work, highlighted how contextual novelty drives this remapping, with the degree of change scaling with the salience of environmental modifications.^[16] In larger or open environments that exceed the scale of typical laboratory arenas, individual place cells frequently develop multiple firing fields rather than a single one, enabling coverage of expansive spaces. Recent analyses across species, including rodents and bats, reveal that these multiple fields vary heterogeneously in shape, size, and spacing, following universal statistical patterns such as Rayleigh-distributed field widths in one-dimensional tracks and exponential gaps between fields in two- or three-dimensional settings.^[17] This multiplicity emerges as environments scale up, contrasting with the singular fields observed in confined spaces, and supports a more flexible, multi-scale representation of navigationally relevant areas.^[17] The underlying mechanisms of remapping and stability involve synaptic plasticity in the hippocampus, particularly long-term potentiation (LTP) and long-term depression (LTD), which adjust connectivity to adapt place field properties without necessarily requiring immediate behavioral changes unless linked to learning. For instance, novelty-induced LTD in CA1 synapses facilitates the initial formation and long-term maintenance of stable fields, as blocking LTD impairs cross-day correlations and accelerates but destabilizes field establishment.^[18] Bidirectional plasticity, encompassing both LTP and LTD, further enables rapid modifications to existing fields during contextual shifts, ensuring the place cell ensemble can reconfigure efficiently.^[19] These plastic processes tie remapping to experience-dependent updates, preserving stability in familiar contexts while allowing adaptive recoding in novel ones.^[18]

Phase Precession

Phase precession refers to the systematic forward shift in the timing of action potentials from hippocampal place cells relative to the ongoing theta rhythm (8–12 Hz), such that spikes occur at progressively earlier phases of the theta cycle as the animal traverses a place field, typically advancing by approximately 180 degrees from the field's entry to exit. This temporal coding mechanism allows individual place cells to fire multiple times within a single theta cycle, with the phase of each spike encoding the animal's current position within the field more reliably than spike timing alone. The phenomenon was first identified in the early 1990s through extracellular recordings from rat CA1 pyramidal cells during spatial navigation tasks on linear tracks. John O'Keefe and Michael Recce observed that place cell bursts consistently began near the trough of the theta wave (around 180–270 degrees) upon entering the place field but precessed forward, often completing a full cycle or more by the field's end, with the degree of precession ranging from 100 to 355 degrees across cells. Subsequent population analyses revealed that this precession compresses sequential activation of place cells representing successive locations into brief theta-cycle "sweeps," effectively representing future positions ahead of the animal's actual trajectory by 100–200 ms.^[20] Mathematically, phase precession is often modeled as a linear advancement of the spike phase φ relative to the animal's position or time, approximated by φ = φ₀ - (v / λ) ⋅ θ, where φ₀ is the entry phase, v is the animal's velocity, λ is the theta wavelength (distance covered per theta cycle, typically 10–20 cm at running speeds), and θ tracks the cycle progression; this form derives from the mismatch between the place cell's elevated intrafield firing rate (slightly faster than theta frequency) and the theta oscillation, producing a phase shift proportional to movement through the field.^[21] In network models, this emerges from asymmetric recurrent excitation in CA3–CA1 circuits, where activity propagates ahead of the sensory input representing the animal's position.^[21] Beyond basic traversal, phase precession facilitates sequence learning by temporally organizing place cell ensembles to encode experienced paths in compressed form, supporting predictive coding of spatial trajectories.^[20] The precession rate—the slope of phase advance per unit distance—varies systematically with behavioral factors: it increases with running speed, as higher velocities traverse fields more quickly relative to theta cycles, and adjusts with environmental novelty, where initial exposures yield shallower slopes that steepen and stabilize over repeated visits as spatial representations mature.^[22]

Directionality and Asymmetry

Place cells in rodents generally exhibit bidirectional firing patterns, activating when the animal passes through a specific location regardless of traversal direction. However, approximately 25% of these cells demonstrate significant directional asymmetry or unidirectional selectivity, often modulated by the animal's head orientation.^[23] This asymmetry arises from interactions with head-direction cells, which provide directional input to refine spatial tuning in the hippocampus. Such directionality becomes particularly prominent in goal-oriented navigation tasks, where place fields adapt to encode intended paths or decisions. For instance, in T-maze alternation paradigms, place cells shift from symmetric to direction-specific firing, with increased selectivity along trajectories toward rewarded arms, supporting route-based memory formation.^[24] This task-dependent emergence highlights how behavioral demands can reshape place cell responses beyond pure location coding.^[25]

Sensory and Behavioral Influences

Visuospatial and Olfactory Inputs

Place cells in the hippocampus are strongly influenced by visuospatial cues, particularly distant landmarks, which serve to anchor and orient their firing fields. Seminal experiments demonstrated that rotating extramaze visual cues, such as a single cue card on the wall of a cylindrical arena, results in a corresponding rotation of place fields by approximately the same angle, indicating that these cues exert precise control over spatial representations. This anchoring effect highlights the reliance of place cells on stable visual landmarks to maintain consistent spatial mapping during navigation. Olfactory inputs contribute to place cell stability through projections from the olfactory bulb to the piriform cortex and lateral entorhinal cortex, which then relay information to the hippocampus. These inputs are particularly crucial in cue-poor or dark environments, where they help sustain place field coherence when visual cues are absent. For instance, in complete darkness, place cell firing patterns initially persist based on recent experience but gradually degrade unless supported by olfactory and tactile cues, demonstrating the compensatory role of olfaction. Studies from the early 2000s further showed that spatial olfactory cues can stabilize place fields even in visually deprived conditions, with field stability increasing when odors are consistently associated with specific locations.^[26] The integration of visuospatial and olfactory cues in place cell activity reveals a hierarchical processing, where visual inputs typically dominate in well-lit environments. In lighted arenas, manipulations of visual landmarks reliably remap place fields, while olfactory cues exert secondary influence unless visual information is removed. However, in darkness, olfactory cues compensate by maintaining field stability, suggesting a multimodal flexibility that adapts to sensory availability. This dominance of visual cues in lit conditions, with olfactory support in low-light scenarios, underscores the hippocampus's ability to prioritize reliable exteroceptive signals for spatial coding.^[26]

Vestibular and Movement Inputs

Place cells receive critical self-motion signals from the vestibular system, which detects head tilts and linear accelerations via the inner ear, helping to maintain the stability of place fields during changes in posture or orientation.^[27] In experiments comparing head-fixed and freely moving rodents, place cell firing remains robust in head-fixed setups on real-world platforms, though vestibular inputs are partially compromised, underscoring their role in supporting spatial representations without full head movement freedom.^[28] These inputs interact with visuospatial cues to anchor place fields to the environment, ensuring coherent mapping.^[29] Path integration, or dead reckoning, further integrates vestibular and motor efference copies—internal signals of self-movement—with optic flow to update place cell activity, allowing brief persistence of firing even in cue-deprived conditions like darkness.^[30] This mechanism enables animals to estimate position from integrated velocity and direction signals, with hippocampal lesions disrupting such dead reckoning behaviors.^[31] Place cells thus rely on these idiothetic cues to sustain spatial tuning temporarily until external landmarks recalibrate the map.^[32] Movement speed profoundly modulates place cell firing rates, with neurons exhibiting higher rates during faster locomotion, as evidenced by velocity tuning curves from early recordings in freely moving rats.^[33] This speed-dependent increase in firing helps encode dynamic navigational states, independent of positional specificity.^[25] Recent two-photon calcium imaging studies reveal diverse calcium dynamics in place field formation, where behavioral time scale synaptic plasticity events—marked by large somatic calcium transients—show a positive correlation between running speed on formation laps and subsequent place field width, highlighting speed's role in shaping spatial selectivity.^[34] In contrast, non-plasticity-like fields emerge with smaller transients uncorrelated to speed, indicating multiple pathways for field establishment influenced by movement vigor.^[34]

Role in Memory Formation

Pattern Completion and Separation

Place cell ensembles in the hippocampus contribute to memory formation by performing pattern completion and pattern separation, two complementary computations that enable the storage and retrieval of spatial representations. Pattern completion allows the retrieval of a complete spatial memory from partial or degraded cues, a process facilitated by the recurrent connections within the CA3 region of the hippocampus. In this mechanism, partial activation of place cells triggers the autoassociative network in CA3 to reconstruct the full pattern of activity corresponding to the original environment, drawing from Tolman-inspired theories of cognitive mapping and formalized in 1990s computational models of hippocampal function.^[35] In contrast, pattern separation orthogonalizes similar input patterns to minimize interference between memories, primarily occurring in the dentate gyrus through sparse, non-overlapping activations of granule cells that project to CA3. This process ensures that distinct engrams form for similar but non-identical environments, preventing catastrophic interference during encoding. Computational models emphasize the role of the dentate gyrus in expanding and decorrelating entorhinal inputs via mechanisms like sparse coding and neurogenesis, which enhance the uniqueness of place cell representations.^[35]^[36] Experimental evidence for these processes comes from studies using the Morris water maze, where removal of distal cues after training leads to preserved spatial performance in control animals, indicating CA3-mediated pattern completion, but impairs performance in mice with CA3-specific NMDA receptor knockouts. Conversely, tasks with overlapping contexts, such as morphed environments, demonstrate pattern separation as place cell firing patterns remap orthogonally in the dentate gyrus and CA3 to distinguish subtle differences. The sparsity of place cell activity, with only a small fraction of cells active at any location, underpins these computations by enabling high-capacity storage of approximately $10^4 to $10^5 bits per environment in the hippocampal network. This sparse coding maximizes the number of distinguishable spatial maps while supporting efficient pattern separation and completion.^[37]

Reactivation, Replay, and Preplay

Place cells demonstrate reactivation during offline states such as rest and slow-wave sleep, where ensembles of neurons fire in coordinated sequences that reconstruct prior spatial experiences. This phenomenon was first observed in rats navigating familiar environments, with place cell activity patterns re-emerging in a temporally compressed manner during these quiescent periods. Reactivation is prominently linked to sharp-wave ripples (SWRs), transient bursts of high-frequency oscillations in the hippocampus ranging from 140 to 200 Hz, which facilitate the synchronous firing of place cell assemblies. A key aspect of reactivation involves the replay of place cell sequences, which can occur in both forward and reverse directions to support memory consolidation and behavioral adaptation. Forward replay, where sequences mirror the temporal order experienced during exploration, often follows rewarding events and contributes to reinforcement learning by reinforcing trajectories leading to goals, such as post-reward paths in spatial tasks. In contrast, reverse replay—sequences played backward from reward locations—has been shown in studies from the 2010s to aid in evaluating potential actions and updating value estimates, with its occurrence uniquely modulated by changes in reward magnitude. Preplay refers to the predictive activation of place cell sequences representing novel, unexperienced spatial paths prior to their occurrence, suggesting a role in prospective planning and schema formation. In rats exposed to new environments, these preconfigured sequences emerge during rest before behavioral exploration, enabling rapid mapping of future trajectories. Recent work has further elucidated how experience-dependent mechanisms, such as synaptic adjustments in hippocampal area CA1, amplify the referencing of relevant place cell replays to maintain flexible cognitive maps.^[38]

Integration with Episodic and Time Coding

Place cells in the hippocampus contribute to episodic memory by integrating spatial information with non-spatial elements, such as objects and events, to encode the "what-where-when" structure of experiences. This binding occurs through conjunctive representations, where place cells form coordinated activity patterns with object-selective neurons in the medial entorhinal cortex and other regions, allowing the hippocampus to associate specific locations with particular items or contexts.^[39] For instance, during object exploration tasks in rodents, place cell firing remaps in response to object novelty or displacement, reflecting the incorporation of "what" and "where" details into spatial codes.^[40] A key mechanism for incorporating the "when" component involves time cells, which are hippocampal neurons that fire sequentially during temporally structured delays in the absence of movement. In CA1 and CA3 subfields, these time cells generate ordered sequences that parallel place cell trajectories, effectively bridging spatial and temporal information to represent spatiotemporal contexts. Pastalkova et al. (2008) identified this phenomenon in rats performing a waiting task on a treadmill, where distinct populations of hippocampal cells activated in a time-locked manner, independent of spatial cues but predictive of subsequent paths.^[41] This integration enables the hippocampus to construct coherent episodic traces that sequence events across both space and time. Recent studies have further elucidated the dynamic interplay between spatial and temporal coding in place cell networks. In a 2024 Neuron investigation, researchers recorded from hippocampal neurons in rodents navigating virtual environments and found evidence of competition between space and time representations, where increasing temporal demands reduced spatial specificity in individual cells, yet overall ensembles maintained integrated space-time codes essential for task performance.^[42] Such mechanisms support flexible navigation by balancing immediate spatial mapping with broader temporal context. Place cell ensembles also facilitate prospective coding, anticipating future events by flexibly adapting population activity to encode potential sequences. A 2025 study demonstrated that novel environmental information triggers enhanced prospective representations in hippocampal place cells, allowing rodents to predict and select among multiple goal-directed paths during decision-making tasks.^[43] This adaptive coding underscores the role of place cells in forward-looking episodic planning, where spatial frameworks extend to temporal forecasting of event outcomes.

Place Cells Across Species

Rodents and Bats

Place cells were first identified in rodents, specifically rats, through extracellular recordings in the dorsal hippocampus, where individual CA1 pyramidal neurons exhibit spatially selective firing patterns known as place fields, typically consisting of one or a few discrete regions of elevated activity during exploration of small enclosed environments like boxes.^[4] These canonical place fields in rodents are often stable across repeated exposures to the same familiar environment, with peak firing rates occurring when the animal is within the field, and they demonstrate robust theta phase precession, where spikes advance progressively earlier in the hippocampal theta rhythm as the animal traverses the field.^[44] In tasks such as the Morris water maze, place cell representations undergo remapping, with fields reorganizing to reflect changes in task demands or environmental modifications, supporting spatial learning and memory formation.^[45] Recent large-scale recordings in mice have confirmed that, in familiar setups, virtually all active CA1 pyramidal cells function as place cells, challenging earlier notions of a sparse coding subset and highlighting the ubiquity of spatial selectivity in this region under stable conditions.00750-3) In bats, place cells have been extensively studied in echolocating species like the Egyptian fruit bat, revealing hippocampal neurons that encode location in three-dimensional space during free flight, with place fields adapting dynamically to volumetric environments and flight trajectories.^[46] These bat place cells, recorded from the dorsal CA1, show expanded fields in larger, open arenas compared to the compact setups typical in rodent studies, and they integrate echolocation-based sensory cues with self-motion signals to maintain spatial representations during rapid, aerial navigation. Unlike the more rigid, landmark-driven fields in rodents, bat place cells exhibit greater flexibility in cue-poor or dynamic settings, such as foraging in unstructured outdoor spaces, where self-motion integration via path integration plays a prominent role in stabilizing firing patterns.^[47] Comparatively, rodent place cells display higher dependence on distal visual cues for stability in controlled lab environments, leading to partial or global remapping when cues are altered, whereas bat place cells demonstrate enhanced resilience through multimodal integration, including vestibular and proprioceptive inputs during flight, which supports navigation in vast, feature-sparse natural habitats.31229-7) Experimental techniques have been pivotal: in rodents, multi-tetrode arrays implanted in the hippocampus enable chronic, high-density extracellular recordings from hundreds of neurons during unrestrained behavior in mazes or open fields, allowing detailed analysis of ensemble dynamics.^[48] In bats, wireless telemetry systems facilitate recordings from freely flying animals in three-dimensional arenas or tunnels, capturing place cell activity without tethering constraints and revealing adaptations to echolocation-guided exploration.^[49]

Primates and Humans

In primates, particularly rhesus monkeys, hippocampal neurons predominantly exhibit properties of spatial view cells rather than pure place cells. These cells respond to allocentric views of specific locations in the environment when the animal gazes toward them, independent of the monkey's own position or head direction.^[50] This visual dominance reflects adaptations for foveal vision and scene processing, contrasting with the path integration-based firing of rodent place cells.^[50] Due to the expanded primate hippocampus, these spatial fields are broader, less sparse, and associated with lower peak firing rates (averaging ~1 Hz) compared to the compact, high-rate fields in rodents.^[51] In humans, intracranial recordings from epilepsy patients during the 2010s identified place-like cells in the hippocampus that demonstrate spatial selectivity during virtual reality navigation tasks. These neurons fire in relation to specific locations within virtual environments, supporting allocentric spatial coding akin to rodent place cells, though often with broader tuning due to methodological constraints in human recordings. Functional MRI studies from 2023 onward have further revealed hippocampal spatial tuning during VR navigation, with theta oscillations modulating position-specific activity near learned locations and boundaries.^[52] A 2025 analysis of place cell detection algorithms applied to human and rat intracranial datasets confirmed similar overall sparsity in firing patterns across species, with only a small fraction of neurons (~10%) active at any given location.^[53] However, human place-like cells exhibited more abstract and diffuse coding, clustering at lower tuning strengths, which may facilitate generalization beyond pure spatial metrics.^[53] These cells also contribute to semantic memory, encoding imagined or verbally described spaces through consistent theta dynamics in the anterior hippocampus, enabling the reconstruction of non-experienced trajectories.^[54]

Non-Mammalian Animals

Research on place cells has extended beyond mammals to non-mammalian vertebrates and invertebrates, revealing evolutionary conservation of spatial coding mechanisms alongside notable differences in stability, neural substrates, and oscillatory patterns. In these species, place-like neurons often exhibit sparse firing and responses to novel environments, but they typically lack the prominent theta rhythms characteristic of mammalian hippocampal activity. These findings suggest that core elements of spatial representation emerged early in vertebrate evolution, adapted to diverse navigational demands such as swimming or flying.^[55] In zebrafish, a teleost fish, place cells have been identified in the dorsal pallium, considered the homolog of the mammalian hippocampus. A 2024 study using brain-wide calcium imaging in freely swimming larval zebrafish demonstrated that pallial neurons form stable spatial representations during virtual navigation tasks, with place fields guiding swimming trajectories in a population code. These fields emerged dynamically, encoding location through coordinated activity across ∼10% of active pallial cells, and showed specificity to visual landmarks, highlighting the role of the dorsal pallium in aquatic spatial mapping. Unlike mammalian place cells, zebrafish representations rely more on population-level decoding rather than individual cell precision, yet they share remapping in response to environmental novelty.^[56]^[56]^[57] Among birds, place-like cells appear in the hippocampal formation and adjacent hyperpallium, adapted for aerial navigation and caching behaviors. In homing pigeons, electrophysiological recordings revealed location cells tuned to specific positions in open arenas, path cells selective for trajectories toward goals, and pattern cells responding to clustered environmental features around reward sites. These cells, recorded in 2017, exhibit spatial selectivity but are less stable across sessions compared to mammalian counterparts, with multiple firing fields and weaker confinement to single locations. In food-caching corvids like black-capped chickadees, a 2021 study identified more stable place cells in the hippocampus, mapping multiple cache sites over weeks and modulating with task context, challenging prior views of inherent instability in avian spatial coding. Bird place cells demonstrate sparsity similar to mammals, firing in only a small fraction of environments, and show enhanced responses to novel spatial configurations during caching tasks. However, avian systems lack theta oscillations, relying instead on other rhythms for coordinating spatial sequences.^[58]^[58]^[55]^[55] Evidence for place-like activity in invertebrates remains limited, with no true spatial map-forming cells identified. In Drosophila melanogaster, mushroom body neurons display place-like tuning during navigation in olfactory-defined arenas, where activity correlates with position in odor gradients rather than visual space. These neurons process combinatorial olfactory cues sparsely, enabling associative spatial learning, but fail to form stable, environment-specific fields akin to vertebrate place cells. Such tuning supports goal-directed behavior in feature-poor environments but represents context-dependent modulation rather than a dedicated spatial map.^[59]^[60]^[61] Across non-mammalian species, place-like cells exhibit conserved features such as sparse activation and sensitivity to novelty, facilitating efficient encoding of salient locations despite divergent brain architectures. For instance, both zebrafish pallial and avian hippocampal neurons remap rapidly to novel cues, mirroring mammalian pattern separation. However, non-mammalian representations often show greater instability over time and sessions, as evidenced by multi-field responses and context-dependent shifts, potentially due to the absence of theta-modulated synchronization. This comparative instability underscores adaptations to ephemeral environments like water or air, while shared sparsity optimizes coding efficiency across phyla.^[55]^[56]^[58]

Pathological and Experimental Disruptions

Substance Effects and Acute Disruptions

Acute administration of ethanol in rodents induces dose-dependent destabilization of hippocampal place fields without causing global silencing of place cell activity. At moderate doses such as 1.0 g/kg intraperitoneally, ethanol reduces the spatial selectivity of place cells by increasing out-of-field firing and decreasing in-field rates, leading to impaired navigational accuracy during intoxication.^[62] Higher doses, around 1.5 g/kg, result in approximately 35% of place fields disappearing, 38% showing reduced firing rates, and about 7-16% exhibiting remapping or novel field emergence, while overall spatial information content remains unchanged.^[63] These effects are reversible upon ethanol clearance and occur alongside partial locomotor slowing, highlighting a selective disruption of spatial encoding rather than broad neural suppression.^[63] NMDA receptor antagonists, such as ketamine, acutely disrupt key temporal dynamics of place cells. At doses of 7.5-50 mg/kg, ketamine preserves the basic mechanism of theta phase precession but reduces its range across the theta cycle by roughly 35% (from ~290° to ~190°), alongside shallower precession slopes and decreased infield firing rates correlated with slowed locomotion.^[64] At 8 mg/kg, ketamine halves the density of sharp-wave ripples (SWRs) and diminishes their associated replay content, impairing the offline reactivation of spatial sequences essential for memory consolidation.^[65] Opioid agonists targeting μ-opioid receptors (MOR) also alter SWR-associated place cell activity in the hippocampus. Application of MOR agonists (1 nM-10 μM) enhances sharp wave amplitude and increases the incidence of SWR sequences but reduces ripple oscillation duration at higher concentrations (≥100 nM), potentially disrupting coordinated population bursts during rest.^[66] Acute manipulations like optogenetic silencing of medial entorhinal cortex (MEC) inputs to the hippocampus cause rapid partial remapping of place fields. Brief inactivation via ArchT or hM4D pharmacogenetics in mice instantly lowers spatial correlations between pre- and post-inactivation maps (e.g., from baseline to r ≈ 0.41), shifting the active CA1 population without altering individual field sizes or spatial tuning.^[67] These substance-induced and acute disruptions correlate with behavioral deficits in spatial tasks, particularly path integration reliant on hippocampal self-motion cues. Low-dose ethanol (0.5 g/kg) fragments the coordinated hippocampal-striatal activity patterns that support vector-based path integration, leading to errors in estimating distance and direction during navigation in rodents.^[68]

Neurodegenerative and Aging Effects

In Alzheimer's disease (AD), amyloid-β accumulation disrupts place cell function, leading to instability in place fields and reduced replay of neural sequences essential for memory consolidation. Studies in Tg2576 mouse models from the 2000s demonstrated that aged transgenic mice exhibit degraded place cell stability, with firing patterns correlating directly with amyloid plaque burden and associated memory deficits.^[69] More recent work in APP^NL-G-F knock-in mice has shown that amyloid-β pathology impairs both rate and temporal coding of spatial information in CA1 place cells, manifesting as fragmented firing fields and diminished precision in representing locations.^[70] These disruptions extend to reduced reactivation of place cell ensembles during sharp-wave ripples, a process critical for offline memory processing, as observed in awake AD mouse models where inhibitory synaptic changes shorten ripple events and weaken sequence replay.^[71] Tau pathology, originating in the entorhinal cortex and spreading to hippocampal regions, further exacerbates place cell dysfunction by altering connectivity between upstream and downstream circuits. In tauopathy models like rTg4510 mice, entorhinal tau accumulation leads to reduced grid cell periodicity, which propagates to impair hippocampal place coding and correlates with spatial memory loss.^[72] This spread induces functional disconnection between CA3 and CA1 subfields, with CA3 place fields shrinking and losing pattern completion capabilities, while CA1 cells show decreased coherence and spatial information content, directly linking these neural changes to AD-related memory impairments.^[73] Human intracranial EEG studies in 2023 have identified similar place cell-like activity in the medial temporal lobe, suggesting that early AD pathology may fragment these representations, though direct causal links remain under investigation in patient cohorts.^[74] Normal aging also progressively degrades place cell properties, independent of overt neurodegeneration, contributing to age-related spatial memory decline. In aged rats, hippocampal place fields broaden significantly—typically by 20-50% compared to young adults—resulting in reduced spatial specificity and less reliable location coding, as documented in 1990s electrophysiological recordings.^[75] This field expansion is accompanied by weakened theta oscillations, with decreased power impairing phase precession, the mechanism by which place cells advance their firing phase relative to the theta rhythm to sequence spatial experiences.^[76] Consequently, aged rodents show poorer pattern separation, a process reliant on precise place cell activity for distinguishing similar environments. Place cell fragmentation has been proposed as an early biomarker of AD, integrating findings from tau and amyloid models, with disrupted place field stability and replay deficits linked to entorhinal tau propagation; hippocampal electrophysiology serves as a sensitive indicator of cognitive vulnerability before widespread plaque or tangle accumulation.^[74]

Developmental and Genetic Disorders

Place cells exhibit significant abnormalities in neurodevelopmental disorders, particularly those involving genetic mutations that disrupt hippocampal synaptic plasticity and network dynamics. In fragile X syndrome (FXS), the most common inherited form of intellectual disability and a leading genetic cause of autism spectrum disorder, Fmr1 knockout rat models demonstrate impaired coordination of CA1 place cell sequences during both active exploration and subsequent rest periods, leading to deficits in spatial sequence representation that may underlie cognitive impairments.^[77] This disruption is linked to the absence of fragile X mental retardation protein (FMRP), which normally regulates mRNA translation at synapses, resulting in overexpression of metabotropic glutamate receptor 5 (mGluR5) and excessive mGluR-dependent long-term depression that compromises sequence stability.^[78] Phase precession, a key mechanism for temporal coding in place cell firing relative to theta oscillations, is also altered in FXS models, with Fmr1-null mice showing shifted spike phases and weakened network correlations, further impairing the ordered activation of place cell ensembles.^[79] In schizophrenia models, such as mice with 22q11.2 deletion syndrome—a genetic risk factor for the disorder—place cell remapping is disrupted due to dopamine dysregulation, leading to unstable spatial representations and impaired goal-directed plasticity in the hippocampus. Dopamine signaling from the ventral tegmental area modulates CA1 place cell reorientation during rule learning, and hyperdopaminergic states in these models promote excitation-inhibition imbalances that prevent adaptive remapping, contributing to cognitive inflexibility observed in schizophrenia.^[80] Similarly, autism-linked mutations, such as those in the chromatin regulator KDM5A, alter hippocampal cell identity and synaptic gene expression.^[81] Genetic knockouts targeting NMDA receptor subunits, like NR2B (encoded by Grin2b), disrupt place field formation during juvenile development by impairing activity-dependent synaptic strengthening in the hippocampus. NR2B-containing NMDA receptors predominate in early postnatal stages and are essential for long-term potentiation at Schaffer collateral-CA1 synapses, with conditional reductions leading to immature place field properties and poor spatial discrimination in young rodents. Therapeutic interventions in FXS models, including optogenetic reactivation of hippocampal engrams—sparse ensembles of place cells encoding specific experiences—have shown promise in rescuing memory deficits by restoring defective reactivation during consolidation, highlighting potential circuit-level treatments for sequence impairments.^[82]

Computational and Theoretical Models

Biophysical Mechanisms of Place Field Formation

Behavioral timescale synaptic plasticity (BTSP) plays a central role in the formation of place fields through synaptic potentiation at synapses between CA3 and CA1 pyramidal neurons. In vitro and in vivo studies have shown that presynaptic activity from CA3 place or grid cells, paired with postsynaptic depolarization in CA1 on behavioral timescales, induces BTSP specifically at these synapses, strengthening connections that align with spatial locations traversed by the animal.^[83] This synaptic strengthening is thought to consolidate weak initial inputs into stable place field representations.^[84] Intrinsic excitability properties of CA1 pyramidal neurons further contribute to place field emergence via calcium dynamics in their dendrites. A 2025 study using in vivo two-photon calcium imaging in head-restrained mice demonstrated that somatic and dendritic calcium transients vary across cells during novel environment exposure, with some place fields forming through gradual increases in dendritic excitability and others via abrupt somatic bursts, highlighting heterogeneous biophysical mechanisms that shape field onset and specificity.^[34] These dynamics allow individual neurons to tune their response thresholds to sensory-driven inputs, enabling the selective activation that defines place fields. Dendritic spikes in CA1 pyramidal cells facilitate nonlinear integration of synaptic inputs, transforming diffuse weak signals into focused, Gaussian-shaped place fields. Research has shown that local dendritic calcium spikes, often preceding somatic firing, amplify coincident excitatory inputs from entorhinal and CA3 sources while suppressing non-coincident ones, thereby generating the bell-shaped firing rate profiles characteristic of place cells.^[85] This nonlinear processing ensures that only spatially tuned input clusters effectively drive output spikes, enhancing the precision of spatial coding. Computational modeling supports these cellular processes by illustrating how recurrent excitation and inhibition balance in CA1 networks underlies place field formation. Sensory inputs from the entorhinal cortex serve as the primary drivers, initiating these biophysical cascades during spatial exploration, with BTSP integrating grid cell metric signals for tuned representations.

Population Coding and Universal Statistics

Place cell ensembles in the hippocampus collectively encode an animal's position through coordinated firing patterns, enabling the reconstruction of spatial trajectories from population activity. Population vector decoding, an early method that weights the preferred locations of individual place cells by their firing rates, has been extended in the 2010s using Bayesian probabilistic models to achieve higher precision. These Bayesian approaches integrate prior knowledge of movement continuity and firing rate maps to infer position, yielding trajectory reconstruction accuracies of approximately 5-10 cm in controlled environments like linear tracks or open arenas. For instance, in foraging tasks, median decoding errors as low as 8 cm were reported using ensembles of 30-50 place cells, with further refinements in real-time applications maintaining errors around 10-15 cm even with smaller populations of 5-10 neurons.^[86]^[87]^[88] Recent theoretical advances have revealed universal statistical properties in place cell firing field distributions, invariant across species, environmental scales, and even dimensionalities. These scale-invariant patterns unify the heterogeneity observed in small, sharply tuned fields typical of rodents in familiar arenas with the broader, more irregular fields seen in large or novel spaces, such as those navigated by bats in complex 3D environments. A 2025 model posits that place fields emerge from a Gaussian random process modulated by variable firing thresholds across neurons, explaining empirical distributions of field sizes, overlaps, and shapes without invoking environment-specific tuning. This framework demonstrates that field statistics follow power-law-like scaling, where larger environments exhibit proportionally more cells with extended or multiple fields, preserving representational efficiency across contexts. In large environments, place cells often exhibit multiple fields, allowing coverage of expansive spaces while maintaining decoding fidelity.^[89] Attractor dynamics provide a foundational mechanism for how place cell populations maintain stable representations and enable continuous remapping between environments via recurrent connectivity in CA3. In the continuous attractor network model, place fields form a smooth manifold where excitatory collaterals in CA3 autoassociative networks stabilize activity bumps corresponding to current position, while path integration updates the attractor state during movement. This architecture accounts for partial remapping—where some cells shift firing locations gradually—facilitating the transition between distinct spatial maps without full reconfiguration. Seminal simulations showed that such dynamics support error correction in self-localization and explain observed field stability over short timescales alongside adaptive remapping in response to contextual changes.^[90] Contemporary computational analyses challenge traditional engram-based interpretations of hippocampal population coding, suggesting that many place cell phenomena arise from effective computations in sparse, random networks rather than structured memory traces. A 2025 study demonstrates that a randomly connected network with sparsifying inhibition—termed DivSparse—replicates key features like field sparsity, stability, and remapping without requiring pre-wired attractors or dedicated engram circuits.^[91] This implies that ensemble-level coding may emerge generically from network sparsity and input statistics, questioning the necessity of experience-dependent synaptic specificity for spatial representations and highlighting the role of inhibitory tuning in universal place cell statistics.

References

[1]
[PDF] Spatial Cells in the Hippocampal Formation - Nobel Prize
The phase of place cell firing is highly correlated with the position of the animal (C). After. O'Keefe and Recce (1993). had been removed (O'Keefe and Speakman ...
[2]
Place Cells, Grid Cells, and Memory - PMC - PubMed Central - NIH
The most striking relationship was noted by O'Keefe and Dostrovsky, who found that hippocampal cells responded specifically to the current location of the ...<|control11|><|separator|>
[3]
[PDF] The Brain's Navigational Place and Grid Cell System - Nobel Prize
The discoveries of place and grid cells by. John O'Keefe, May-Britt Moser and Edvard I. Moser present a paradigm shift in our understanding of how ensembles ...
[4]
The hippocampus as a spatial map. Preliminary evidence ... - PubMed
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res. 1971 Nov;34(1):171-5. doi: ...
[5]
The hippocampus as a spatial map. Preliminary evidence from unit ...
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Author links open overlay panelJ. O'Keefe, J. Dostrovsky.
[6]
[PDF] The Hippocampus as a Cognitive Map - Faculty
John O'Keefe & Lynn Nadel (1978) The Hippocampus as a Cognitive Map ,. Oxford University Press. You may redistribute the file electronically providing you do ...
[7]
The 2014 Nobel Prize in Physiology or Medicine - Advanced ...
John O'Keefe discovered place cells in the hippocampus that signal position and provide the brain with spatial memory capacity. May-Britt Moser and Edvard I ...Missing: challenges replication
[8]
[PDF] Placing hippocampal single-unit studies in a historical context
However, the primary impetus for the theory was a finding reported by O'Keefe and Dostrovsky in 1971. The authors reported that the firing rates of a number of ...
[9]
The Nobel Prize in Physiology or Medicine 2014 - Press release
Oct 6, 2014 · Other nerve cells were activated when the rat was at other places. O'Keefe concluded that these “place cells” formed a map of the room. More ...
[10]
Microstructure of a spatial map in the entorhinal cortex - Nature
Jun 19, 2005 · Here we show that the dorsocaudal medial entorhinal cortex (dMEC) contains a directionally oriented, topographically organized neural map of the spatial ...
[11]
Spatial Firing of Hippocampal Place Cells in Blind Rats
Mar 1, 1998 · The firing rate of place cells in blind rats was lower according to ... cell firing in the place field to the previous behavior of the rat.
[12]
The Hippocampal Rate Code: Anatomy, Physiology and Theory - PMC
In contrast, MEC has very few silent cells and the active cells have a six-fold higher mean firing rate: around 2.5 Hz [32] (Figure 2G). The firing of all ...
[13]
Universal statistics of hippocampal place fields across species and ...
Apr 2, 2025 · We present a model that explains irregular CA1 responses in large environments. The theory explains statistics of field sizes, arrangement, and shape ...Results · Parameter Variation Across... · Star Methods
[14]
What do grid cells contribute to place cell firing? - PMC - NIH
It is commonly assumed that grid cell inputs generate hippocampal place fields, but recent empirical evidence brings this assumption into doubt.
[15]
None
### Summary of Place Cell Stability and Remapping
[16]
https://www.jneurosci.org/content/jneuro/7/7/1951.full.pdf
[17]
LTD is involved in the formation and maintenance of rat ... - Nature
Jan 4, 2021 · Therefore, the specific role of LTP and LTD in regulating place cell encoding dynamics and the subsequent consolidation of their stable place ...
[18]
Bidirectional synaptic plasticity rapidly modifies hippocampal ... - eLife
Dec 9, 2021 · We found that this behavioral timescale synaptic plasticity (BTSP) can also reshape existing place fields via bidirectional synaptic weight changes.
[19]
Theta phase precession of grid and place cell firing in open ...
Effects of firing and running speed on phase precession, in cells that show significant phase precession versus pdcd (place cells above and grid cells below).
[20]
Place cells on a maze encode routes rather than destinations - eLife
Jun 10, 2016 · One way of answering this question is to study the brains of rats, because the basic plan of a rodent's brain is similar to that of other ...
[21]
Experience-dependent firing rate remapping generates directional ...
(Rat 1 ran on the circular track twice a day, so the afternoon session of day 1 was considered session 2 and analyzed with the other rats' day 2, and the ...
[22]
Spatial View Cells in the Primate Hippocampus - Rolls - 1997
In a sample of 352 cells recorded in the hippocampus and parahippocampal cortex, a population of 'spatial view' cells was found to respond when the monkey ...Missing: 1990s | Show results with:1990s
[23]
https://www.cell.com/cell/fulltext/S0092-8674(15)01639-6
[24]
Contribution of multiple sensory information to place field stability in ...
In the present study, we assessed the effects of removing visual and/or olfactory cues on place field stability.Missing: stabilizing | Show results with:stabilizing
[25]
https://pmc.ncbi.nlm.nih.gov/articles/PMC3282921/
[26]
https://pubmed.ncbi.nlm.nih.gov/10706218/
[27]
Hippocampal Spatial Representations Require Vestibular Input - PMC
These results indicate that vestibular signals provide an important influence over the expression of hippocampal spatial representations.
[28]
Place Cells in Head-Fixed Mice Navigating a Floating Real-World ...
Place cells have been readily recorded using electrophysiological techniques in freely moving mice and rats. However, additional insight into system function ...Missing: bidirectional unidirectional
[29]
Interactions Between Idiothetic Cues and External Landmarks in the ...
The firing properties of place cells and head direction cells are controlled by an interaction between landmarks and idiothetic cues, just as an animal's ...
[30]
Dead reckoning (path integration) requires the hippocampal formation
We present a series of studies that suggests that dead reckoning is an important component of spontaneous exploratory behavior and the learned spatial behavior ...
[31]
Dead reckoning (path integration) requires the hippocampal formation
When dead reckoning (deduced reckoning or path integration), they integrate self-movement cues over time to locate a present position or to return to a starting ...
[32]
Spatial representations of place cells in darkness are supported by ...
Contribution of multiple sensory information to place field stability in hippocampal place cells. ... Spatial olfactory learning contributes to place field ...
[33]
The contributions of position, direction, and velocity to single unit ...
The place/direction specificity of CS cells was significantly higher in CA1 than in CA3 and CA3 CS cells exhibited a striking preference for the inward radial ...Missing: rate | Show results with:rate
[34]
Diverse calcium dynamics underlie place field formation in ... - eLife
Sep 30, 2025 · In a novel environment, many CA1PCs are active already during the first traversal of their PFs, but a fraction of cells become place cells after ...
[35]
The mechanisms for pattern completion and pattern separation in ...
The aim of this paper is to describe some of the different types of pattern separation and pattern completion in the hippocampal system, and the mechanisms ...
[36]
Pattern separation in the hippocampus - PMC - NIH
Separation and completion are not synonymous with remapping and stability. Place cell remapping is typically defined as place cells having distinct firing ...
[37]
Place cells, spatial maps and the population code for memory
In this review, we show how hippocampal place cells have been recently used as a model system to advance our understanding of how location and memory are ...
[38]
Mechanisms of experience-dependent place-cell referencing in ...
Apr 1, 2025 · Together, these results suggest that experience-dependent adjustment of synaptic input shapes PC referencing to support a flexible cognitive map ...
[39]
Episodic memory: Neuronal codes for what, where, and when
Jul 23, 2019 · For instance, sequences of place cells are compressed within theta cycles so that place cells coding passed or upcoming locations are active ...
[40]
Object-translocation induces event coding in the rat hippocampus
May 24, 2025 · In this study, we aimed to distinguish the “where” and “what” components of local object memory by analyzing place cell activity across the ...
[41]
Internally generated cell assembly sequences in the rat hippocampus
We found that reliably and continually changing cell assemblies in the rat hippocampus appeared not only during spatial navigation but also in the absence of ...
[42]
Integration and competition between space and time in ... - PubMed
Nov 6, 2024 · The results strongly suggest a competitive and integrated representation of space-time by single hippocampal neurons, which may provide the ...
[43]
New information triggers prospective codes to adapt for flexible ...
May 24, 2025 · Here we show that new information triggered increased hippocampal prospective representations of both possible goals.
[44]
Theta phase precession in hippocampal neuronal populations and ...
Theta phase precession is when cell spike activity advances to earlier theta cycle phases. Temporal sequences of place fields are compressed within theta ...
[45]
Hippocampal place cell remapping occurs with memory storage of ...
Jul 19, 2023 · We conclude that place cell remapping occurs in response to events that are remembered rather than merely perceived and forgotten.
[46]
Hippocampal cellular and network activity in freely moving ... - PubMed
Here we report the first hippocampal recordings from echolocating bats, mammals phylogenetically distant from rodents, which showed place cells very similar to ...
[47]
[PDF] Spatial cognition in bats and rats: from sensory acquisition to ...
Two recent studies showed that rat place fields were significantly smaller when visual landmarks were present than when they were absent171,172. In a different ...
[48]
Comparing Mouse and Rat Hippocampal Place Cell Activities and ...
Sep 20, 2018 · We provide a quantitative comparison in place field properties, as well as theta sequences and replays, between rats and mice as they ran on the same novel ...Missing: diameter | Show results with:diameter
[49]
3D Hippocampal Place Field Dynamics in Free-Flying Echolocating ...
Aug 22, 2018 · We present data from the free-flying laryngeal echolocating big brown bat, which shows 3-D place cells without continuous theta.Abstract · Introduction · Materials and Methods · Discussion
[50]
Neural Correlates of Spatial Navigation in Primate Hippocampus
Nov 2, 2022 · Last, monkey “place fields” are often dispersed and not as sparse, and the peak firing rate is much lower than that in rodents. Therefore, place ...Neural Correlates Of Spatial... · Theta Phase Coding In... · Eye Movement Coding And Head...
[51]
Dynamic neural representations of memory and space during ...
Oct 20, 2023 · These results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.
[52]
Evaluating Place Cell Detection Methods in Rats and Humans
Sep 3, 2025 · Each paper was reviewed for key methodological features including recording site, behavioral task, spatial tuning analysis, and classification ...
[53]
Human neural dynamics of real-world and imagined navigation
Mar 10, 2025 · In navigational tasks featuring repetitive segments, such as ours, place cells and grid cells tend to form repetitive firing sequences that ...
[54]
Neural representations of space in the hippocampus of a food ...
Jul 16, 2021 · Unlike place cells observed in mammals, hippocampal activity reported in non-mammals is neither confined in space nor stable over time (14–18).Missing: instability | Show results with:instability<|control11|><|separator|>
[55]
A population code for spatial representation in the zebrafish ... - Nature
Aug 28, 2024 · In this study, using tracking microscopy to record brain-wide calcium activity in freely swimming larval zebrafish, we compute the spatial ...
[56]
Coupling of Sharp Wave Events between Zebrafish Hippocampal ...
Apr 24, 2024 · Single-cell calcium imaging coupled to local field potential recordings revealed that ∼10% of active cells in the dorsal telencephalon ...
[57]
Are There Place Cells in the Avian Hippocampus? - PubMed
Sep 4, 2017 · Research with homing pigeons has discovered hippocampal cells, including location cells, path cells, and pattern cells, that share some but not all properties ...Missing: hyperpallium | Show results with:hyperpallium
[58]
Visual Place Learning in Drosophila melanogaster - PubMed Central
Place cells, grid cells, and the brain's spatial representation system. Annu ... Drosophila mushroom bodies are dispensable for visual, tactile, and motor ...
[59]
Spatial learning in feature-impoverished environments in Drosophila
Dec 2, 2024 · Our findings demonstrate that Drosophila can dynamically adapt to environmental complexities when solving spatial learning tasks by creating and ...<|control11|><|separator|>
[60]
Finding a place and leaving a mark in memory formation - PMC
Place memory formation in Drosophila While, such cells within specific regions have not yet been identified in invertebrates, circuit analysis of spatial ...
[61]
Ethanol alters spatial processing of hippocampal place cells - PubMed
This study describes a new mechanism by which ethanol alters brain function and may impair performance on tasks requiring spatial navigation.
[62]
Acute Effects of Ethanol on Hippocampal Spatial Representation ...
Nov 5, 2020 · Acute alcohol exposure impairs hippocampus-dependent spatial memory. However, there is little evidence for the effects of ethanol on the spike ...
[63]
Hippocampal phase precession is preserved under ketamine, but ...
Ketamine did not affect the ability of CA1 place cells to precess despite changes to place cell firing rates, local field potential properties and locomotor ...
[64]
NMDA receptors promote hippocampal sharp-wave ripples and the ...
NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2) receptors-implications for models of schizophrenia.Missing: precession | Show results with:precession
[65]
Effects of μ-opioid receptor modulation on the hippocampal network ...
Key results: All three MOR agonists (1 nM-10 μM) significantly increased the amplitude of sharp waves and the occurrence of SWR sequences, but reduced the ...
[66]
Hippocampal Remapping after Partial Inactivation of the Medial ...
Nov 4, 2015 · Partial inactivation of medial entorhinal cortex causes remapping in the hippocampus. Inactivation-induced remapping is instantaneous.
[67]
Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate ...
In the other behavioral or Western blot tests, each rat was only received one treatment. Behavioral Apparatus and Pre-training. Rats were trained according to ...
[68]
Place cell firing correlates with memory deficits and amyloid plaque ...
We have recorded place cells in the Tg2576 mouse model of AD, and we report that aged (16 mo) but not young (3 mo) transgenic mice show degraded neuronal ...
[69]
Hippocampal place cells exhibit impairments in spatial information ...
Jun 16, 2023 · APPNL-G-F CA1 place cells exhibited deficits in both rate coding and temporal coding of spatial information indicating that amyloid β pathology, ...
[70]
Impaired speed encoding & grid cell periodicity in mouse tauopathy
Nov 26, 2020 · Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, ...
[71]
Spatial memory deficits in Alzheimer's disease and their connection ...
Place cell abnormalities have been reported in different mouse models of AD. rTg4510 mice (7–8 months) with advanced tau pathology and progressive ...
[72]
Brain Aging: Changes in the Nature of Information Coding by the ...
Jul 1, 1997 · Advanced age in rats is associated with a decline in spatial memory capacities dependent on hippocampal processing.
[73]
The Effect of Aging on Experience-Dependent Plasticity of ...
As the place fields expanded, the rate of change of firing with phase slowed accordingly, so that the net phase change remained constant. Thus changes in field ...
[74]
Entorhinal‐based path integration selectively predicts midlife risk of ...
Feb 29, 2024 · Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell ...
[75]
Hippocampal Place Cell Sequences Are Impaired in a Rat Model of ...
Apr 9, 2025 · To be included for further analysis, the peak firing rate in a place field had to be at least 1 Hz, and the minimum length of a place field had ...
[76]
Defective memory engram reactivation underlies impaired fear ...
Nov 20, 2020 · Activity-dependent genetic labeling during behavioral learning shows Fragile-X syndrome model mice exhibit impaired hippocampal engram ...
[77]
Hippocampal Place Cell Firing Patterns Can Induce Long-Term ...
Overlapping place cell pairs are required for the induction of synaptic plasticity. A corollary of the model by which LTP allows synapses between place cells to ...Missing: remapping | Show results with:remapping
[78]
Bidirectional Hebbian Plasticity at Hippocampal Mossy Fiber ...
Dec 24, 2008 · We propose that MF LTP in LM interneurons preserves the sparsity of pyramidal cell activation, thus allowing CA3 to maintain its role in pattern separation.
[79]
A realistic computational model for the formation of a Place Cell
Dec 8, 2023 · We used a morphologically and biophysically detailed computational model of a CA1 pyramidal neuron to show how, and under which conditions, it can turn into a ...
[80]
A Statistical Paradigm for Neural Spike Train Decoding Applied to ...
Sep 15, 1998 · For animal 1 (2) the median decoding error based on 34 (33) place cells recorded during 10 min of foraging was 8.0 (7.7) cm.Missing: centimeters | Show results with:centimeters
[81]
Real-Time Position Reconstruction with Hippocampal Place Cells
Real-time decoding: the position reconstruction algorithm uses the on-line sorted spikes and the firing rate vector as inputs to predict the position of the ...
[82]
Efficient neural decoding of self-location with a deep recurrent network
Based on observation of place cell activity it is possible to accurately decode an animal's location. The precision of this decoding sets a lower bound for the ...<|control11|><|separator|>
[83]
Path Integration and Cognitive Mapping in a Continuous Attractor ...
Aug 1, 1997 · A minimal synaptic architecture is proposed for how the brain might perform path integration by computing the next internal representation of self-location.