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Promethium

Promethium is a synthetic with the symbol Pm and 61, classified as a in the periodic table and notable for being one of only two elements (along with ) that occur naturally on in only trace amounts due to the absence of stable isotopes. As a soft, silvery metal, it tarnishes slowly in air and reacts readily with water, exhibiting typical lanthanide properties such as a of 1042°C and a of approximately 3000°C, while its is [Xe] 4f⁵ 6s². All known isotopes of promethium are radioactive, with promethium-145 having the longest of 17.7 years and promethium-147 being the most commonly used due to its 2.62-year half-life and pure emission, making it suitable for specialized applications. Discovered in 1945 at by Jacob A. Marinsky, Lawrence E. Glendenin, and Charles D. Coryell through ion-exchange separation of products from , promethium was named after the Titan from , who stole fire from the gods, symbolizing humanity's quest for knowledge. Although not found in significant natural deposits on , promethium has been detected in trace amounts in stars and is produced artificially via nuclear reactors for its primary uses, including as a beta source in thickness gauges for measuring thin films, in nuclear batteries powering devices like pacemakers and space probes, and in luminous paints for self-sustaining light sources. Recent advances in promethium chemistry, such as studies of its coordination complexes, are enhancing understanding of and potentially unlocking new applications in and .

Properties

Physical properties

Promethium is the with and [Xe] 4f⁵ 6s². Its is approximately 185 pm, based on empirical measurements for lanthanides. Promethium is a silvery metal that tarnishes in air due to oxidation. It has an extrapolated of 7.26 g/cm³ at , a of 1042°C, and a of 3000°C. These values are derived from limited experimental data and analogies with neighboring lanthanides, as promethium's radioactivity complicates direct measurements. The metal exhibits a double hexagonal close-packed in its α-phase, with lattice parameters a = 3.65 and c = 11.65 . Promethium is paramagnetic, consistent with its unpaired f-electrons.
PropertyValueNotes/Source
Thermal conductivity17.9 W/(m·K)Estimated at
Electrical conductivity1.3 × 10⁶ S/mDerived from resistivity of ~0.75 µΩ·m
Due to its radioactivity, all physical properties of promethium are studied using short-lived isotopes like ¹⁴⁷Pm, with data often extrapolated from bulk samples containing impurities.

Chemical properties

Promethium, as a member of the series, predominantly exhibits the +3 , forming the with an ionic radius of 97.0 pm in six-coordinate environments. This trivalent state arises from the loss of the 6s² electrons and one 4f electron, resulting in a [Xe] 4f⁴ configuration for the ion, which is characteristic of lanthanide chemistry. Higher oxidation states are unstable and rarely observed due to the poor shielding of the 4f electrons. The element is highly electropositive, reflecting its position among the reactive lanthanides, and thus displays vigorous reactivity with common substances. Promethium reacts slowly with cold to produce gas and promethium(III) (Pm(OH)₃), with the reaction accelerating in hot . It tarnishes rapidly in moist air by oxidizing to form promethium(III) oxide (Pm₂O₃) and dissolves readily in dilute acids, such as hydrochloric or , to generate corresponding salts like PmCl₃ or Pm(NO₃)₃, accompanied by evolution. Among its key compounds, promethium(III) oxide (Pm₂O₃) is a pale -white solid prepared by calcining promethium or at elevated temperatures around 800–1000°C. Promethium(III) (PmCl₃), a , water-soluble , is synthesized by dissolving promethium metal or in or by fusing the oxide with . Similarly, promethium(III) (PmF₃), a white crystalline compound, is obtained via from aqueous Pm³⁺ solutions with ions or by direct reaction of the metal with gas. In coordination chemistry, Pm³⁺ ions typically form complexes with coordination numbers ranging from 6 to 9, favoring high coordination due to the large ionic radius and electrostatic bonding preferences of lanthanides. A landmark advancement came in 2024 with the characterization of the first stable promethium coordination complex in aqueous solution, a 1:3 homoleptic species formed with a tridentate diglycolamide ligand, where nine oxygen atoms coordinate the metal center, enabling detailed study via X-ray absorption spectroscopy. This complex highlights promethium's ability to form chelates despite its radioactivity. Promethium's chemical behavior is largely analogous to adjacent lanthanides but exhibits subtle differences attributable to its neutral [Xe] , which influences orbital energies and leads to intermediate properties between (4f⁴) and (4f⁶), including variations in bond lengths and reactivity trends within the series. The half-filled nature approaching the 4f subshell contributes to distinct spectroscopic signatures, though its overall reactivity remains governed by the +3 ionic state.

Isotopes

Promethium possesses no isotopes, with all known isotopes being radioactive. As of recent evaluations, 38 isotopes have been characterized, with mass numbers ranging from 128 to 166. The primary decay modes for lighter isotopes (below mass 146) are leading to daughters, while heavier isotopes predominantly undergo beta-minus decay to . The most stable isotope is ^{145}Pm, with a half-life of 17.7 years, decaying primarily by electron capture (nearly 100%) to stable ^{145}Nd, with an extremely rare alpha decay branch (2.8 × 10^{-7} %) to ^{141}Pr. The next longest-lived is ^{147}Pm, with a half-life of 2.623 years, undergoing pure beta-minus decay to stable ^{147}Sm. Another notable isotope, ^{146}Pm, has a half-life of 5.53 years and decays via both electron capture (66%) to ^{146}Nd and beta-minus decay (34%) to stable ^{146}Sm. These isotopes are the only ones with half-lives exceeding one year, making them relevant for potential applications despite their radioactivity. Traces of promethium, specifically ^{145}Pm and ^{147}Pm, occur in uranium ores such as pitchblende due to the of ^{238}U, though in quantities less than one per million tonnes of (as of current data, 2023); these amounts are insufficient for practical and rapidly. The following table summarizes selected promethium isotopes, focusing on those with relatively longer half-lives, including their decay modes and daughter products (abundances are negligible and not naturally occurring):
Mass NumberHalf-LifeDecay Mode(s)Daughter Product(s)
^{143}Pm265 daysElectron capture (100%)^{143}Nd
^{144}Pm360 daysElectron capture (100%)^{144}Nd
^{145}Pm17.7 yearsElectron capture (nearly 100%); α (2.8 × 10^{-7} %)^{145}Nd; ^{141}Pr
^{146}Pm5.53 yearsElectron capture (66%); β⁻ (34%)^{146}Nd; ^{146}Sm
^{147}Pm2.623 yearsβ⁻ (100%)^{147}Sm
^{148}Pm5.37 daysβ⁻ (100%)^{148}Sm
^{149}Pm2.21 daysβ⁻ (100%)^{149}Sm
Data derived from nuclear databases; shorter-lived isotopes (half-lives <1 day) are omitted for brevity. Regarding nuclear properties, ^{147}Pm has thermal neutron capture cross sections of 84 ± 10 barns to ^{148}Pm (ground state) and 72.4 ± 3.0 barns to ^{148m}Pm, influencing its behavior in nuclear reactors where it acts as a .

Occurrence and production

Natural occurrence

Promethium is one of the rarest elements in the Earth's crust, with an estimated abundance of less than $10^{-15} g/kg, making it orders of magnitude scarcer than other lanthanides. This trace presence arises almost exclusively from the spontaneous fission of , which produces short-lived isotopes such as ^{145}Pm (half-life 17.7 years) and ^{147}Pm (half-life 2.62 years) with cumulative fission yields of approximately 2% for ^{147}Pm and similar for other short-lived isotopes. A minor contribution comes from the alpha decay of naturally occurring ^{151}Eu. These isotopes contribute to a total natural inventory of approximately 500–600 grams distributed across the entire crust at any given time. Promethium has been detected in minute traces within uranium-bearing ores, such as , where it forms as a byproduct of spontaneous fission processes. However, no concentrated deposits or minerals containing promethium exist, due to its rapid radioactive decay and the infinitesimal production rates. In cosmic environments, promethium is synthesized via the rapid neutron-capture process () in core-collapse supernovae and neutron star mergers, events that generate neutron-rich heavy nuclei including . Its cosmic abundance remains negligible, as the unstable isotopes decay quickly, but trace detections have been reported in the spectra of peculiar stars like HD 25354 through analysis of promethium II lines. Unlike other rare earth elements, which feature stable isotopes and form economically viable ores like monazite or bastnäsite, promethium fills a unique gap in the lanthanide series with virtually no stable accumulation, rendering its natural occurrence insignificant for geological or practical purposes.

Synthetic production

Promethium is primarily produced synthetically through neutron bombardment of enriched neodymium-146 targets in high-flux nuclear reactors, such as the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory (ORNL). The key nuclear reaction involves the capture of a thermal neutron by ^{146}\mathrm{Nd}, forming ^{147}\mathrm{Nd}, which undergoes beta-minus decay to yield the most commonly produced isotope, ^{147}\mathrm{Pm}: ^{146}\mathrm{Nd}(n,\gamma)^{147}\mathrm{Nd} \rightarrow \beta^- \rightarrow ^{147}\mathrm{Pm}. This process achieves yields of up to 2.75 mCi per milligram of target material after approximately 24 days of irradiation at neutron fluxes around $2.1 \times 10^{15} n/cm²/s, though longer irradiations do not significantly boost output due to the high neutron capture cross-section of ^{147}\mathrm{Pm}. Impurities, such as ^{147}\mathrm{Nd} (up to 3.13%) and minor isotopes like ^{148\mathrm{m}}\mathrm{Pm} (0.64%), arise from competing reactions but can be minimized using highly enriched targets (>99% ^{146}\mathrm{Nd}). An alternative production route exploits promethium as a fission byproduct in nuclear reactors fueled by or plutonium-239. The cumulative fission yield for ^{147}\mathrm{Pm} from thermal neutron-induced fission of ^{235}\mathrm{U} is approximately 2.23%, meaning about 2.23 atoms of ^{147}\mathrm{Pm} are produced per 100 fissions. This method historically supplied larger quantities before shifts in reprocessing, with promethium extracted from alongside other fission products. Separation techniques include solvent extraction using organic extractants like di(2-ethylhexyl)orthophosphoric acid (HDEHP) and ion-exchange , which achieve decontamination factors exceeding $10^4 from and other lanthanides, yielding purities over 99% with recovery rates up to 90%. To obtain metallic promethium, purified ^{147}\mathrm{Pm} compounds, typically the fluoride \mathrm{PmF_3}, are reduced using or metals at elevated temperatures. Reduction with vapor in a crucible proceeds via $2\mathrm{PmF_3} + 3\mathrm{Li} \rightarrow 2\mathrm{Pm} + 3\mathrm{LiF}, while reduction follows $2\mathrm{PmF_3} + 3\mathrm{Ca} \rightarrow 2\mathrm{Pm} + 3\mathrm{CaF_2}; both reactions occur under at temperatures around or above the metal's of 1042°C to ensure complete conversion and minimize oxidation. These methods have produced milligram-scale samples of promethium metal with densities near 7.26 g/cm³, though the material's radioactivity limits handling to glove boxes or hot cells. Recent advances at ORNL in 2025 have improved separation efficiency by characterizing promethium coordination complexes in aqueous solution for the first time, using ligands like diglycolamides to form stable Pm³⁺-oxygen bonds. X-ray absorption spectroscopy revealed bond lengths and electronic structures that explain promethium's separation behavior relative to neighboring lanthanides, enabling higher-purity isolation (>99.9%) from mixed fission or irradiation products via targeted chelation and chromatography. These developments, supported by quantum chemistry simulations, enhance yield and scalability for research applications. Worldwide annual production of promethium remains limited to tens of grams, predominantly as ^{147}\mathrm{Pm}, with the U.S. Department of Energy's Program at ORNL serving as the primary supplier alongside limited contributions from Russian reactors.

History

Early searches for element 61

The existence of element 61 was anticipated in the late as part of the series in Dmitri Mendeleev's periodic table, where gaps appeared between (atomic number 60) and (62) due to the progressive filling of 4f orbitals leading to the —a phenomenon causing atomic radii to decrease across the series, making chemical separation challenging for unstable elements like this one. In 1902, chemist Bohuslav Brauner refined Mendeleev's table by extending the row after , explicitly predicting an undiscovered element at position 61 with properties intermediate between and , based on atomic weight discrepancies in rare earth minerals. This prediction gained empirical support in 1914 when Henry Moseley's experiments confirmed a missing at 61 among the lanthanides, solidifying the theoretical gap. Searches for element 61 intensified from the early 1900s through the 1940s, primarily involving fractional crystallization and spectroscopic analysis of rare earth concentrates from minerals like , but these efforts were hampered by the element's absence in nature owing to its lack of stable isotopes—all known isotopes have half-lives shorter than 18 years, preventing geological accumulation. Pioneering work began around 1912 with American chemist Charles James at the , who amassed large quantities of rare earths for separation studies, followed by B. Smith Hopkins at the starting in 1923, both using laborious techniques without success. Several premature claims emerged during this period, later debunked as misidentifications of impurities. In 1924, Italian chemists Luigi Rolla and Rita Brunetti at the reported isolating a rare earth fraction with spectral lines suggesting a new element, proposing the name florentium after their city; however, reanalysis in the 1930s revealed the lines belonged to known lanthanides like , and Rolla retracted the claim in 1941 following scrutiny by . Similarly, in 1926, B. Smith Hopkins, along with Len Yntema and J.A. Harris at the , announced the discovery of illinium from monazite residues, based on faint emissions and naming it after their state; subsequent independent verifications, including by Austrian chemist Friedrich Adolf Paneth in 1927, showed the sample was contaminated with and other impurities, invalidating the claim. Another unconfirmed report came in 1938 from Laurence Quill's team at , who produced short-lived isotopes via bombardment and suggested the name cyclonium, but lacked chemical characterization. These pre-1945 searches culminated during the , where the need to analyze uranium fission products from atomic bomb development provided the breakthrough. In 1945, Jacob A. Marinsky, Lawrence E. Glendenin, and Charles D. Coryell at successfully identified element 61 using ion-exchange chromatography on fission products from , revealing its beta-emitting isotopes and confirming its position in the series—thus completing the rare earth row after decades of elusive pursuit.

Discovery and initial synthesis

Promethium, element 61, was first identified in 1945 by Jacob A. Marinsky, Lawrence E. Glendenin, and Charles D. Coryell at the in . Working under wartime secrecy during the , the team isolated the element from the fission products of irradiated in the Graphite Reactor. They employed ion-exchange chromatography to separate rare earth fission products and identified promethium through its characteristic properties, specifically the decay chain involving isotopes such as promethium-147, which emits beta particles with energies around 0.225 MeV. This breakthrough filled the last gap in the lanthanide series, as prior attempts to find a stable isotope had failed due to its radioactivity. The discovery was not publicly announced until December 1947, when Marinsky, Glendenin, and Coryell published their findings in the Journal of the American Chemical Society, detailing the chemical separation and radioactive identification of the new element. Independent confirmation came in 1951 through absorption and emission spectroscopy by William F. Meggers, Bourdon F. Scribner, and William R. Bozman at the National Bureau of Standards, who analyzed a sample of promethium chloride and identified spectral lines consistent with its position between neodymium and samarium in the periodic table, including prominent absorption bands at 494.5, 548.5, 568.0, 685.5, and 735.5 nm. Early isolations yielded only microgram quantities, limited by the low fission yield of promethium isotopes (about 0.25% for Pm-147 from U-235 fission) and the challenges of handling highly radioactive materials. In 1949, the International Union of Pure and Applied Chemistry (IUPAC) officially approved the name "promethium" (symbol Pm) for element 61, honoring the Greek Titan who stole fire from the gods to benefit humanity—a nod to the element's nuclear origins and potential. This replaced temporary designations like "cl" proposed in some early reports. The first synthesis of pure promethium metal occurred in 1963, when Fritz Weigel at the University of Munich reduced promethium(III) fluoride (PmF₃) with vapor in a crucible at 1100-1200°C, producing approximately 50 mg of the metal with reported purity over 99%. This marked the initial production of weighable amounts of the element, enabling further studies of its physical properties despite its rapid self-irradiation damage due to .

Recent research advances

In the early 2000s, research on promethium shifted toward advanced spectroscopic techniques to overcome its scarcity and radioactivity, enabling the first detailed studies of its coordination chemistry. A pivotal advancement occurred in 2024 through collaborative efforts at (ORNL) and (BNL), where scientists synthesized and characterized the first stable promethium in using the bispyrrolidine diglycolamide (PyDGA) . This [Pm(PyDGA)3]3+ complex allowed for the determination of Pm–O bond lengths at 2.476(16) Å via synchrotron (XAS) at BNL's National Synchrotron Light Source II (NSLS-II). These measurements confirmed the effect, with promethium exhibiting an accelerated shortening of ionic radii compared to neighboring elements, completing the structural trend across the lanthanide series from to . Building on this, DOE-funded research in March 2025 at ORNL further characterized a promethium-147 coordination complex, providing insights into its electronic structure and bonding behavior distinct from other lanthanides. By stabilizing the complex with an organic ligand in solution, researchers used XAS to reveal subtle electronic differences that influence , advancing techniques for separating promethium from nuclear fission byproducts—building on the 2024 of the first Pm complex. This work, supported by the DOE Office of Science and Isotope Program, highlighted how promethium's properties can inform improved purification methods for rare earth elements. In April and May 2025, ORNL studies uncovered hidden electronic properties of promethium through , demonstrating deviations in its orbital interactions that aid in modeling the behavior of rare earth elements and their analogs. These findings, derived from stabilized promethium-147 complexes, revealed how promethium's position in the periodic table influences overall bonding trends, with potential applications in simulating chemistry for waste processing. For instance, the observed trends support the development of ligands that selectively extract and from , enhancing efficiency in waste remediation. Despite these progress, challenges persist due to promethium's short isotope half-lives—such as 2.62 years for 147—and its synthetic , limiting experiments to microgram-scale samples produced via reactors. These constraints necessitate specialized facilities like hot cells at ORNL and sources, restricting sample volumes to approximately 20 μg in solution for accurate measurements. Ongoing research continues to address these limitations through computational modeling and targeted to expand promethium's study for broader geochemical and applications.

Applications

Established uses

Promethium, particularly the isotope ¹⁴⁷Pm, has found limited but established applications due to its beta-emitting and . These uses primarily emerged during the mid-20th century, leveraging its radioactivity for low-power, long-duration sources and measurement tools. One key application is in batteries, specifically betavoltaic cells that convert energy into electricity. ¹⁴⁷Pm-powered betavoltaic batteries were developed for cardiac pacemakers in the , providing reliable, long-term power without frequent replacements; the Betacel model 400, for instance, used ¹⁴⁷Pm coupled with semiconductors to deliver stable output for medical implants. Similar devices powered remote sensors and guided missiles, capitalizing on the isotope's 2.62-year for sustained low-level energy in harsh environments. Production of ¹⁴⁷Pm for these batteries peaked during the era at facilities like the , where gram-scale quantities were extracted from products for military and space-related needs. In luminous paints, ¹⁴⁷Pm is mixed with to create self-luminous materials that emit light without external excitation, ideal for low-light visibility. These paints were applied to watch dials, instrument panels, and military equipment like gauges during the mid-20th century, offering persistent glow from beta-induced ; however, they were largely phased out by the in favor of tritium-based alternatives due to handling concerns. Historical use extended to space applications, including illumination of instruments in Apollo lunar modules. Promethium also serves as a beta source in industrial thickness gauges, where ¹⁴⁷Pm emissions measure material density and thickness in manufacturing processes. Beta particles from the isotope are attenuated by passing through thin films, , plastics, or metal sheets, allowing non-destructive, precise gauging of thicknesses down to micrometers; this technique has been standard in for and converting industries since the 1950s. In research settings, ¹⁴⁷Pm acts as a tracer for chemical analysis, tracking reaction pathways and material flows in laboratory studies due to its detectability via .

Potential and emerging applications

Promethium's potential in nuclear batteries centers on developing improved long-life versions for deep-space probes, leveraging isotopes like ¹⁴⁵Pm with its 17.7-year half-life to provide sustained power over extended missions. In 2025, researchers at advanced promethium-147 production by extracting it from byproducts, potentially increasing availability for nuclear battery applications. A 2024 study on coalescent energy transducers highlights promethium-147's role in micronuclear batteries, achieving higher efficiency through beta-emitting phosphors integrated with photovoltaic cells, which could extend operational lifespans for probes in harsh environments. Advances in promethium research, including the first promethium observed in using diglycolamide ligands, have improved separation techniques. These separation breakthroughs correlate with lanthanide contraction trends, enabling more precise isolation that could streamline industrial recycling of rare earths. Additionally, quantum chemical modeling of promethium's f-block electronic structure, using absorption and computational simulations, provides accurate data. In and tracers, promethium's emission offers promise for targeted , particularly with like promethium-149, which deliver high-energy electrons to destroy tumor cells while minimizing damage to surrounding tissues. Studies on promethium-149 DOTA-bombesin analogs demonstrate selective binding to cancer receptors, enabling precise delivery with low gamma emission for safer administration. A 2022 review of rare earth radionuclides underscores promethium's potential in theranostics, combining and , though clinical translation lags due to isotope availability. Despite these prospects, promethium's applications face significant challenges from its extreme , with annual production limited to tens of grams, and inherent , which complicates handling, increases costs, and limits scalability for widespread use. Its beta poses risks, including tissue damage, necessitating stringent shielding and specialized facilities that hinder commercial viability. Ongoing aims to mitigate these barriers through improved synthesis, but current production constraints from byproducts remain a primary obstacle.

Safety and precautions

Health effects

Promethium poses health risks primarily through its , with the most common isotope, (¹⁴⁷Pm), emitting particles that can cause internal damage upon or . These particles have a maximum energy of 0.225 MeV and an average energy of 0.062 MeV, enabling them to penetrate the outer layers of but not deeper tissues, resulting in potential superficial burns from external to high-activity sources; however, the greater danger arises from internal , where particles deposit energy locally in organs. As a , promethium exhibits chemical akin to other rare earth elements, with low gastrointestinal absorption (approximately 0.007% in adult rats) but potential accumulation in bones and the liver following uptake, which may lead to or other organ damage over time. Promethium-147 is classified as highly radiotoxic, with an annual limit of intake () for occupational exposure via ingestion of 1.5 × 10⁸ (4 × 10³ µCi), corresponding to a committed effective dose equivalent of 0.05 , and critical organ effects on the lower wall; vary by class (D: 2.6 × 10⁸ , W: 7.4 × 10⁷ , Y: 7.4 × 10⁷ ). No specific (LD₅₀) data exist for promethium, but extrapolations from lanthanide analogs suggest acute oral in the range of several grams per kilogram body weight in . Chronic exposure to promethium increases cancer risk due to the ionizing effects of its beta , particularly in the and , though promethium has no known essential biological role in humans. Epidemiological data on promethium specifically are limited owing to its rarity and synthetic nature, with insights derived from studies on analogs showing associations with and hepatic dysfunction in occupationally exposed populations.

Handling and environmental considerations

Promethium, primarily in the form of the promethium-147, requires careful handling due to its and chemical reactivity. Operations involving promethium are typically conducted within gloveboxes to contain radioactive aerosols and prevent , as demonstrated in purification processes at facilities like (ORNL). For , emissions from promethium-147 can be effectively shielded using as little as 0.2 mm of plastic material, while alpha shielding is unnecessary for this but may apply if trace contaminants are present. Storage must occur in inert atmospheres, such as argon-filled gloveboxes with oxygen levels below 500 ppm, to inhibit oxidation and formation of promethium oxide (Pm₂O₃), which could compromise sample integrity. Regulatory oversight for promethium falls under international and national frameworks for radioactive materials, rather than special nuclear materials classification, given its status as a non-fissile product. The (IAEA) governs its safe transport through standards outlined in SSR-6, requiring that maintains under normal and accident conditions. In the United States, the (NRC) regulates possession, use, and disposal via 10 CFR Part 20, with transport compliant to rules aligned with IAEA, often under 2915 for low specific activity radioactive material in excepted packages. These protocols emphasize labeling, monitoring with body and ring badges, and limits on airborne concentrations to 4 × 10⁻¹¹ μCi/mL for promethium-147 in uncontrolled areas. Environmental impacts from promethium are limited by its negligible natural occurrence and low global production volumes, estimated at less than 1 gram annually from processes. As a component of , promethium can bioaccumulate in organisms, with studies showing uptake by freshwater , potentially entering food chains if released from waste streams. However, its relatively short of 2.62 years for promethium-147 restricts long-term environmental persistence, as the decay product samarium-147 poses reduced radiological risks over time. Disposal of promethium-bearing follows high-level nuclear protocols, primarily through , where products are incorporated into matrices for and long-term storage in geological repositories. opportunities arise during reprocessing, where promethium-147 can be separated via ion-exchange or solvent extraction for reuse in applications like thickness gauges, thereby diverting it from streams. As of 2025, advances in coordination chemistry and synchrotron-based characterization have enabled more efficient separation techniques, such as improved complexation in aqueous solutions, reducing overall volumes by enhancing recovery yields from production byproducts.

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