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Tanning

Tanning is the physiological darkening of triggered by exposure to (UV) radiation, in which melanocytes in the increase production of —a photoprotective that absorbs excess UV to mitigate DNA damage in underlying cells, though the process itself reflects prior cellular injury rather than conferring net protection. Originally a marker of outdoor labor shunned by elites favoring pale complexions, cosmetic tanning emerged as a in the early 20th century, notably popularized in the 1920s by fashion icons like whose Riviera vacations showcased bronzed skin as emblematic of leisure and vitality, inverting prior beauty norms. Indoor methods proliferated from the 1970s with UV-emitting beds developed for controlled exposure, alongside non-UV alternatives like chemical self-tanners using to stain the . While proponents cite potential upsides such as vitamin D synthesis from UVB-induced cutaneous conversion of 7-dehydrocholesterol, controlled studies affirm that tanning's UV doses yield insufficient or inconsistent gains outweighed by harms, with supplementation recommended over exposure. Pivotal controversies center on substantiated carcinogenic effects: UV-driven tanning elevates risks of melanoma by up to 75% with pre-35 indoor use, basal cell carcinoma by 24%, and squamous cell carcinoma by 58%, via direct DNA mutations and immunosuppression, establishing no safe tanning threshold. Additional sequelae include photoaging through collagen degradation and oxidative stress, underscoring tanning as a biomarker of cumulative dermal trauma rather than benign enhancement.

Biological Foundations

Mechanism of Skin Tanning

Skin tanning primarily results from ultraviolet (UV) radiation exposure, which triggers melanin production and redistribution in the epidermis as a protective response against further DNA damage. Melanin, synthesized in melanosomes by melanocytes, absorbs and scatters UV photons, dissipates heat, and acts as an antioxidant to mitigate oxidative stress from reactive oxygen species generated by UV. This process involves two distinct phases: immediate pigment darkening (IPD) and delayed tanning (DT). IPD occurs rapidly upon UVA exposure (320–400 nm), oxidizing pre-existing melanin and its precursors (such as 5,6-dihydroxyindole) without new synthesis, leading to transient darkening that peaks within minutes to hours and fades within days due to reduction of oxidized melanin. Delayed tanning, the more persistent form, develops 2–3 days after UVB exposure (280–320 nm) and lasts weeks, driven by melanogenesis. UVB induces cyclobutane and other DNA lesions in , activating , which upregulates pro-opiomelanocortin (POMC) gene expression. POMC cleavage yields alpha-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH), which bind melanocortin-1 receptor (MC1R) on , elevating cyclic AMP (cAMP) levels. This activates (MITF), enhancing expression—the rate-limiting enzyme that catalyzes oxidation to dopaquinone, precursor to eumelanin (photoprotective black-brown polymer) or pheomelanin (red-yellow, less protective). Increased dendricity facilitates transfer to suprabasal , where aggregates form supranuclear caps shielding nuclei from UV. MC1R variants influence tanning efficacy; loss-of-function alleles (common in fair-skinned individuals) reduce signaling, favoring pheomelanin and impairing repair, heightening and cancer risk, while gain-of-function promotes eumelanin. Repetitive UV exposure amplifies DT by proliferating melanocytes and thickening the , though initial doses prioritize over melanogenesis, explaining the lag. Overall, tanning reflects a hormetic : suberythemal UV doses enhance pigmentation for photoprotection, but excess overwhelms repair, causing .

Evolutionary and Adaptive Aspects

Human skin pigmentation exhibits latitudinal clines shaped by to optimize protection against radiation (UVR) while balancing synthesis requirements. In equatorial regions with intense year-round UVR, darker constitutive pigmentation—dominated by eumelanin—evolved to absorb and dissipate UVR, thereby reducing risks of DNA damage, folate photolysis, and . Conversely, in higher latitudes with lower UVR intensity, lighter skin facilitates UVB penetration for cutaneous production, preventing and supporting immune function, with selection pressures acting over approximately 10,000–20,000 years following human migrations . These adaptations reflect a compromise: excessive pigmentation in low-UV environments impairs sufficiency, while insufficient pigmentation in high-UV areas elevates photobiological risks. Facultative pigmentation, or tanning, represents an inducible layer of defense superimposed on constitutive pigmentation, triggered by UVR-induced DNA damage and reactive oxygen species in keratinocytes and melanocytes. This response activates melanogenesis via pathways involving p53 and melanocortin-1 receptor (MC1R), leading to increased eumelanin deposition in the epidermis within days of exposure, which scatters and absorbs subsequent UVR to mitigate further cellular damage. Tanning's adaptive value lies in its plasticity, providing graded photoprotection proportional to exposure intensity; for instance, it can increase skin's minimal erythema dose by up to threefold, correlating with reduced sunburn incidence in populations with robust tanning capacity. Genetic variants enhancing tanning efficiency, such as those in SLC24A5 and TYR, have been positively selected in regions with fluctuating UVR, like Europe and East Asia, where weakened facultative responses in some groups contributed to overall depigmentation while retaining baseline protection. Empirical evidence from and underscores tanning's evolutionary refinement. Studies of MC1R polymorphisms reveal that loss-of-function alleles, prevalent in lightly pigmented populations (e.g., up to 80–100% in red-haired individuals), impair tanning and heighten UV sensitivity, suggesting ancestral selection favored variants enabling rapid upregulation in variable climates. and genetic data indicate that early Homo sapiens likely possessed darkly pigmented skin capable of tanning, with and modulated tanning emerging post-dispersal to mitigate deficits rather than UV excess. While tanning confers short-term survival advantages against acute UV damage, its incomplete shielding (equivalent to 3–4) highlights it as a supplementary, not primary, , with modern behaviors often overriding these mechanisms.

Methods of Tanning

Natural Sun Exposure

Natural sun exposure induces tanning through the penetration of ultraviolet B (UVB) and ultraviolet A (UVA) radiation from sunlight into the skin, where UVB rays primarily trigger DNA damage in keratinocytes, prompting melanocytes to increase melanin production as a protective response. This process begins within hours of exposure, with visible darkening typically appearing after 48-72 hours as melanin granules distribute throughout the epidermis. UVA rays contribute to deeper, more persistent pigmentation but with less immediate erythema. The efficacy and safety of tanning via natural sunlight depend on skin phototype, classified by the , which categorizes individuals based on constitutive skin color, eye and hair pigmentation, and response to UV exposure: Type I (pale white skin, always burns, never tans), Type II (fair skin, usually burns, tans minimally), Type III (light brown, sometimes burns, tans gradually), Type IV (olive, rarely burns, tans easily), Type V (brown, very rarely burns, tans deeply), and Type VI (dark brown or black, never burns, deeply pigmented). Those with Types III-VI achieve more uniform and sustained tans due to higher baseline and efficient melanogenesis, while Types I-II risk before pigmentation. Genetic factors, including variations in melanocortin-1 receptor (MC1R) genes, further modulate tanning response, with loss-of-function variants in fair-skinned individuals reducing output. Environmental variables significantly influence UV dose and tanning outcomes. Peak UVB intensity occurs between 10 a.m. and 4 p.m., when the is low, maximizing ground-level radiation; however, exposure duration must be titrated to avoid or burns, with higher latitudes and winter months reducing available UVB by up to 90% compared to equatorial summer conditions. Gradual acclimation—starting with 10-15 minutes for lighter types and extending to 20-30 minutes for darker types in moderate UV index (3-7)—promotes constitutive tanning by upregulating melanocytes without overwhelming repair mechanisms. Altitude increases UV exposure by 4-10% per 1,000 meters due to thinner atmospheric filtering, accelerating the process. A base tan, equivalent to SPF 2-4, emerges after repeated sub-erythemal exposures, but requires ongoing maintenance as melanin turnover limits persistence to weeks without reinforcement. Reflective surfaces like or can amplify effective dose by 10-50%, necessitating adjusted exposure times. Unlike artificial methods, natural tanning synchronizes with circadian and seasonal rhythms, potentially aligning with endogenous synthesis pathways, though cumulative dose remains the primary determinant of pigmentation depth.

Artificial UV Tanning Devices

Artificial UV tanning devices, also known as sunbeds or solaria, are electromechanical systems that emit (UV) radiation to induce skin pigmentation through production, simulating the effects of natural . These devices include lie-down tanning beds, vertical stand-up booths, and smaller sunlamps for targeted exposure, typically found in commercial salons, spas, or home units. They operate using arrays of fluorescent lamps, metal halide lamps, or high-pressure mercury lamps coated with phosphors to produce specific UV wavelengths. The primary radiation output consists of (315–400 nm) rays, which penetrate deeper into to promote tanning with minimal immediate burning, comprising approximately 95–99% of the in modern , alongside 1–5% UVB (280–315 nm) for initial and synthesis stimulation. Exposure sessions are timer-controlled, typically lasting 5–20 minutes depending on type, intensity, and user tolerance, with built-in cooling fans and surfaces to facilitate user comfort. Users wear protective to shield against ocular damage, though compliance varies. Developed in the mid-20th century by Friedrich Wolff, who patented a UV-emitting cabin in , these devices gained commercial traction in before entering the U.S. market in 1979 via Friedrich Wolff Corporation. Popularity surged in the with the rise of and year-round access, leading to over 30,000 U.S. salons by the early . Indoor tanning prevalence has declined due to awareness campaigns and restrictions; in the U.S., past-year usage among adults was 5.6% in 2010, dropping to about 1.4% overall by 2023–2025 surveys, with higher rates among young white females (up to 5.7% in adolescents). Globally, adult usage hovered at 10.4% from 2013–2018, though underreporting may occur in self-reported data. The U.S. (FDA) regulates these as Class II medical devices since 2014, requiring premarket notification, performance standards for emission limits, and mandatory warnings on and risks, with output capped to prevent excessive exposure. Many states enforce age minimums of 18 years, for minors, or outright bans for those under 18, alongside session logging and equipment maintenance mandates. Internationally, the classifies UV tanning devices as carcinogenic, prompting varied bans in countries like and .

Chemical and Non-UV Alternatives

Chemical self-tanning primarily relies on (DHA), a three-carbon derived from plant sources, which interacts with the to produce a coloration without (UV) exposure. When applied topically, DHA undergoes a non-enzymatic with free , particularly , , and , in the dead of the 's outer layer, forming brown pigments that mimic a tanned appearance. This process typically develops over 2-6 hours post-application and lasts 3-10 days, depending on skin exfoliation rates, as the color resides solely on the surface and does not penetrate viable skin layers or stimulate production. The U.S. (FDA) classifies DHA as a safe color additive for external use in since 1977, with concentrations up to 15% in over-the-counter products. DHA is frequently combined with erythrulose, a tetrose keto-sugar produced via fermentation, to enhance tan uniformity and longevity. reacts more slowly than DHA—developing over 24-48 hours—and targets similar amino groups in the , yielding a complementary reddish-brown hue that reduces streaking and dryness associated with DHA alone. This synergy results in a more natural, streak-resistant color that persists longer, often up to 7-10 days with repeated applications. Products incorporating both agents, such as lotions, mousses, creams, and spray tans, allow for customizable shade intensity through layering or formulation strength, with professional spray applications delivering even coverage via airbrush technology. While effective for cosmetic purposes, self-tanners carry limitations and potential risks distinct from UV methods. The artificial color can appear unnatural on certain tones, may cause in sensitized individuals due to formulation additives, and imparts a characteristic acrid odor from volatile byproducts. Inhalation of DHA during spray tanning raises concerns, as indicate genotoxic potential in cells, prompting FDA warnings against use on mucous membranes or in enclosed spray booths without protection; human epidemiological data on long-term risks remain limited. Nonetheless, peer-reviewed analyses affirm self-tanners as a lower-risk alternative to UV tanning, avoiding DNA damage and photocarcinogenesis while potentially reducing UV-seeking behaviors among users. Oral tanning agents, such as those containing canthaxanthin, deposit in subcutaneous fat but lack efficacy for epidermal tanning, pose risks like crystal-induced at doses exceeding 30 mg daily, and are not FDA-approved for this purpose. Temporary bronzers, comprising pigments or temporary dyes in makeup formulations, offer non-reactive color enhancement that washes off with and , providing an immediate but fleeting alternative without chemical binding to skin proteins. These differ from DHA-based methods by not altering composition, making them suitable for short-term use but unsuitable for sustained simulation. Emerging non-UV options, such as topical melanogenesis stimulators like pseudocatalase for vitiligo-related repigmentation, remain investigational and non-generalizable for cosmetic tanning. Overall, chemical self-tanners predominate as the principal non-UV strategy, balancing aesthetic outcomes with minimized carcinogenic hazards relative to photobiological tanning.

Health Effects

Documented Benefits

Exposure to ultraviolet (UV) radiation that induces skin tanning promotes endogenous vitamin D synthesis in the epidermis, where UVB rays convert cutaneous 7-dehydrocholesterol to previtamin D3, which thermally isomerizes to vitamin D3 (cholecalciferol). This process is the primary natural source of vitamin D for most individuals, supporting calcium absorption, bone mineralization, and skeletal health; deficiencies are prevalent in regions with limited sunlight, such as northern latitudes, affecting up to 1 billion people globally with risks of rickets, osteomalacia, and osteoporosis. Vitamin D also modulates immune function, reducing susceptibility to respiratory infections and autoimmune diseases, as evidenced by randomized trials showing supplementation or sun-derived vitamin D lowers acute infection rates by 12-70% in deficient populations. UVA radiation during tanning sessions mobilizes (NO) from skin stores, leading to and reduced ; a 2014 study found that whole-body UVA exposure lowered systolic by 5-8 mmHg in healthy adults, comparable to antihypertensive effects, with sustained cardiovascular benefits observed over weeks. This NO release may contribute to decreased cardiovascular mortality, as epidemiological data link higher lifetime sun exposure to lower prevalence, independent of levels. Tanning elevates serum beta-endorphin levels by up to 44% in healthy adults after controlled UV exposure, an endogenous that induces analgesia and , potentially explaining the rewarding sensation of tanning and associated mood enhancement. This response correlates with increased serotonin production, alleviating symptoms in some studies, though effects vary by individual phototype and exposure duration. Moderate tanning has been linked to short-term immune modulation, including enhanced antimicrobial peptide production in , but long-term data remain limited.

Proven Risks and Pathophysiology

Ultraviolet (UV) radiation from sun exposure or artificial tanning devices induces tanning through the activation of melanocytes, which produce as a partial protective response to DNA damage in . UVB (290-320 nm) primarily causes direct DNA lesions such as cyclobutane (CPDs) and 6-4 photoproducts (6-4 PPs), while UVA (320-400 nm) penetrates deeper, generating (ROS) that indirectly damage DNA via . These lesions, if unrepaired by mechanisms, lead to mutations, including C>T and CC>TT signature transitions characteristic of UV-induced skin cancers. The extends to chronic inflammation and (ECM) degradation: UV triggers matrix metalloproteinases (MMPs) that break down and , resulting in manifested as wrinkles, loss of elasticity, and leathery texture. Tanning itself signals cumulative epidermal injury rather than harmless pigmentation, as production lags behind initial DNA damage and offers only minimal subsequent shielding (SPF ~2-4). Proven risks include non-melanoma skin cancers and . Indoor tanning elevates (SCC) risk by 58% and (BCC) risk by 24%, with ever-use associated with relative risks of 1.39 for , 1.39 for BCC, and 1.58 for SCC in meta-analyses. First use before age 35 increases risk by approximately 75%, with dose-response relationships showing higher odds per session or year of exposure. Photoaging is causally linked to UV via alterations and senescence, with clinical signs appearing after cumulative doses equivalent to years of unprotected . Additional effects encompass UV-induced , reducing delayed-type and increasing infection susceptibility, alongside acute risks like sunburn from vascular and release. The International Agency for Research on Cancer classifies UV-emitting tanning devices as carcinogens, affirming causal links through mechanistic and epidemiological evidence.

Empirical Evidence from Studies

Numerous randomized controlled trials and observational studies have demonstrated that (UV) radiation from sun exposure or artificial sources induces cutaneous synthesis of 3 by converting to previtamin D3, which thermal isomerizes to vitamin D3, elevating serum 25-hydroxy D levels. For instance, a 2022 found that moderate sun exposure significantly improved serum 25(OH)D concentrations in individuals with low intake, complementing dietary sources without exceeding safe limits. Indoor UV tanning devices similarly boost production, as evidenced by controlled exposure experiments showing dose-dependent increases in circulating vitamin D metabolites, though long-term safety remains debated due to UV intensity. Beyond vitamin D, empirical evidence from randomized trials indicates UV exposure, particularly UVA wavelengths, releases nitric oxide stores from the skin into systemic circulation, reducing blood pressure. A 2018 double-blind trial exposed participants to whole-body UVA irradiation at two doses (40 kJ/m² and 80 kJ/m²), resulting in significant decreases in systolic blood pressure (by 5-7 mmHg) and increased plasma nitrite levels, independent of vitamin D changes. A 2022 randomized controlled trial of daily UVA phototherapy for two weeks similarly lowered clinic and 24-hour ambulatory blood pressure in hypertensive patients via nitric oxide-mediated vasodilation. These effects were more pronounced in fair-skinned individuals and suggest potential cardiovascular benefits from controlled UV exposure. On risks, meta-analyses of epidemiological data link artificial tanning to elevated incidence. A 2007 International Agency for Research on Cancer (IARC) review of 19 studies reported a 1.75-fold increased risk with first sunbed use before age 35, with ever-use associated with 15-20% higher odds overall. studies, such as a analysis of over 140,000 women, found before age 30 raised risk by 30-50%, with dose-response trends for sessions exceeding 30 lifetime uses. Non-melanoma skin cancers show similar patterns: correlates with 24% higher and 58% higher risks in pooled analyses. However, these associations are stronger for intermittent high-intensity exposure mimicking sunburns rather than gradual tanning, and confounding factors like skin type and total UV dose complicate in observational designs. For natural sun exposure, evidence is more nuanced; chronic occupational UV exposure increases non-melanoma rates (e.g., 67-95% per 1 kJ/m² ambient UV increase in incidence studies), but recreational moderate exposure without burns shows weaker or null links to in some cohorts. Limitations in many risk studies include reliance on self-reported exposure, failure to distinguish burning from tanning, and potential biases toward overemphasizing harms amid campaigns, though DNA damage mechanisms (e.g., cyclobutane ) provide biological plausibility for cumulative risk. Overall, while benefits accrue from sub-erythemal doses, exceeding thresholds elevates , underscoring dose-dependency.

Historical Context

Early Perceptions and Practices

In , dating back to approximately 3100–300 BCE, pale skin was culturally preferred among the , symbolizing and avoidance of manual labor under the sun; to achieve this, applied natural substances such as rice bran, jasmine flowers, and lupine seeds mixed with water or animal fats to whiten and protect the skin from solar exposure. This practice reflected a broader perception that tanned or darkened skin indicated lower associated with outdoor toil, prompting the use of rudimentary sunscreens for cosmetic rather than protective health reasons. Among ancient Greeks from the Archaic period (circa 800–480 BCE), pale skin in women was idealized as a marker of indoor and high status, contrasting with the tanned or reddish-brown depictions of men in art, which connoted physical activity and masculinity; literary sources like mocked deviations from this norm, reinforcing that sun-induced tanning was undesirable for females. Similarly, in (circa 753 BCE–476 CE), elite women employed lead-based whiteners and parasols to maintain , viewing tanned skin as a sign of servile fieldwork rather than refinement. Early therapeutic sun exposure, known as heliotherapy, emerged in Greek medicine around the 5th century BCE, with prescribing controlled sunlight for treating conditions like tuberculosis precursors, though this focused on health benefits such as synthesis rather than aesthetic tanning; such practices inadvertently resulted in skin darkening but were not pursued for cosmetic enhancement. Perceptions in these civilizations thus prioritized sun avoidance for beauty and class distinction, with intentional tanning absent until much later eras.

Rise of Modern Tanning Culture

The preference for pale skin, long associated with and avoidance of manual labor, began to invert in the early as a tanned complexion came to symbolize , , and among the affluent. This cultural pivot is often traced to 1923, when French fashion designer disembarked from a yacht on the with an inadvertent suntan from extended sun exposure; her visible bronzed skin, photographed and publicized upon returning to , prompted widespread emulation among elites and marked tanning as a fashionable marker of sophistication and vacationing abroad. Scientific endorsements of sunlight's benefits further propelled the trend, building on early 20th-century discoveries like Niels Finsen's 1903 in for against and other ailments, which shifted perceptions from sun avoidance to controlled exposure for vitality and production. By the and , advertisements and medical advice promoted sunbathing as therapeutic, aligning with the aesthetic appeal; for instance, in 1928, designer launched Huile de Chaldée, the first commercial tanning oil, designed to enhance and accelerate the tanning process while offering minimal protection. Post-World War II, tanning solidified as a emblem of youth and athleticism in , with swimwear brands like advertising tanned models without hats or gloves by , and exemplifying the look amid rising beach culture and affordable travel. The trend intensified in the and with self-tanning products entering markets—such as Coppertone's Quick Tanning Lotion in 1960—and the commercialization of devices, pioneered in around 1976 by Friedrich Wolff's high-pressure lamps, leading to a boom in U.S. salons numbering over 18,000 by 1985 as consumers sought year-round access. This era's tanning enthusiasm persisted despite emerging data, driven by psychological associations with confidence and sex appeal, though retrospective analyses note how media underplayed risks while amplifying benefits like mood enhancement from endorphin release during UV exposure. By the late , tanning culture had permeated youth demographics, with surveys indicating over 30% of American adolescents engaging in by the 1990s, reflecting entrenched norms before campaigns began challenging the practice.

Sociocultural Dimensions

Beauty Standards and Symbolism

In Western societies prior to the , pale skin was the predominant ideal, symbolizing and as it indicated avoidance of outdoor manual labor typically associated with lower classes. Tanned or darkened skin, by contrast, connoted physical toil and was thus undesirable among elites, a perception reinforced through , , and cosmetic practices like lead-based whitening in , , and Elizabethan . This paradigm shifted dramatically in the when designer returned from a yacht trip on the with a visible suntan, which was photographed and emulated as a marker of modernity, leisure, and vitality. The tan inverted prior class symbolism: now signifying access to exotic travel and sun-drenched vacations affordable only to the affluent, rather than labor, it aligned with emerging ideals of health and athleticism promoted by figures like and later Hollywood stars. Empirical assessments of attractiveness support the enduring preference for moderate tanning. In a 2020 study, participants rated images of individuals with a medium tan as most attractive and healthy-looking, outperforming both untanned skin and heavy tans. Similarly, surveys indicate that approximately 40% of U.S. adults perceive themselves as more attractive when tanned, with users particularly associating it with enhanced confidence and appeal. These perceptions persist despite health risks, driven by cultural norms equating bronzed with youth and outdoor activity, though preferences vary globally—fair remains idealized in many Asian contexts as a sign of refinement over manual exposure.

Psychological and Behavioral Drivers

The pursuit of a tanned is primarily driven by aesthetic motivations, with individuals seeking to enhance perceived attractiveness and align with cultural standards associating bronzed with , , and youthfulness. A of qualitative studies on users identified appearance enhancement as the dominant reason, often overriding awareness of health risks. Perceived psychological benefits further reinforce tanning behaviors, including mood elevation, relaxation, and increased self-confidence following exposure. Users report tanning as a means to achieve and social fitting-in, with some describing euphoric effects akin to reward-seeking activities. These subjective gains contribute to habitual engagement, particularly among adolescents and young adults influenced by media portrayals of tanned ideals. Body image dissatisfaction and depressive symptoms are significantly correlated with frequent tanning, suggesting that individuals with lower may use tanning to compensate for perceived physical shortcomings. In a of students, those exhibiting higher levels of and body dissatisfaction reported more positive attitudes toward tanning and greater frequency of sun exposure or indoor sessions. Skin tone dissatisfaction specifically predicts tanning intentions, as lighter-skinned individuals seek darker tones to meet normative expectations. Behavioral dependence on tanning mirrors addiction profiles, with evidence of compulsive use, , and symptoms such as restlessness or when access is denied. Prevalence estimates indicate that up to 20-30% of frequent tanners meet criteria for , often co-occurring with anxiety, substance use, and other impulse-control issues. This pattern aligns with UV-induced beta-endorphin release fostering , though psychological craving for appearance maintenance plays a central role. Social influences amplify these drivers, including peer norms where friends who tan encourage similar behaviors, and parental permissiveness in adolescents. Intentional tanning correlates with broader risk-taking, such as or use, indicating shared traits. Despite campaigns, these entrenched psychological and behavioral factors sustain tanning persistence, particularly in cultures prioritizing tanned over pale skin connotations of or .

Controversies and Debates

Risk Assessment and Overstatement Claims

Critics of stringent anti-tanning policies argue that the risks of (UV) exposure from tanning—particularly for —have been overstated, citing methodological flaws in epidemiological studies and a disconnect between s and absolute harms. A detailed critique of the International Agency for Research on Cancer's (IARC) 2006 on sunbed use found that the summary (RR) of 1.15 (95% CI: 1.00–1.31) for ever-use of sunbeds became non-significant (RR 1.09, 95% CI: 0.96–1.24) after excluding studies inadequately adjusted for factors like skin phenotype (e.g., fair skin types predisposed to ) and (where lower ambient UV correlates with higher reported risks due to travel behaviors). This analysis emphasized that observational data cannot reliably disentangle sunbed effects from broader solar UV exposure or genetic predispositions, undermining claims of direct causality. Relative risk figures, such as the often-quoted 75% increase in for initiated before age 35, are presented without sufficient context on absolute increments, which remain small against 's low baseline incidence (e.g., population-attributable fractions for estimated at 2.6–9.4%, implying limited population-level impact even at high prevalence). Moreover, epidemiological patterns reveal paradoxes: incidence may trend upward with recreational sun exposure in some cohorts, yet mortality does not correspondingly rise, as observed in high-UV regions like where improved diagnostics inflate incidence without proportional lethality. Animal and human studies on chronic, moderate UV exposure similarly show no consistent promotion, contrasting with clear causation for non-melanoma skin cancers like . These overstatement claims extend to messaging, where moderate outdoor tanning's potential benefits—such as vitamin D synthesis mitigating broader mortality risks—are downplayed amid emphasis on intermittent burns or high-dose indoor sessions, which differ mechanistically from gradual exposure. Proponents of recalibration advocate for nuanced risk stratification by skin type and exposure patterns rather than blanket prohibitions, noting unresolved questions in UV and tumor subtypes (e.g., melanomas on non-exposed sites less tied to cumulative UV). Such perspectives highlight how institutional biases toward caution may amplify perceived dangers without proportional evidence of harm from controlled tanning.

Vitamin D and Moderation Arguments

Exposure to ultraviolet B (UVB) radiation from sunlight triggers the cutaneous synthesis of vitamin D3, converting 7-dehydrocholesterol in the skin to previtamin D3, which isomerizes to vitamin D3. This process is maximized with exposure levels that avoid skin burning, typically requiring only brief periods of midday sun on a portion of the body surface. Moderate sun exposure, such as 5–10 minutes on the face, arms, and legs several times per week depending on skin type and latitude, can elevate serum 25-hydroxyvitamin D levels to sufficient ranges (30–50 ng/mL) for most individuals without inducing erythema. Endocrinologist Michael Holick, a leading researcher on vitamin D metabolism, advocates this "sensible" approach as complementary to supplementation, emphasizing that it provides vitamin D plus ancillary benefits like nitric oxide production for cardiovascular health. Adequate from such exposure supports skeletal integrity by enhancing calcium absorption and reducing fracture risk, while also modulating immune responses through like cathelicidins, potentially lowering incidences of autoimmune diseases and respiratory infections. Observational data link higher status to 30–50% reduced risks for colorectal, , and cancers, alongside benefits in prevention. , prevalent in up to 40% of populations with limited sun exposure, correlates with elevated all-cause mortality and poorer cancer prognoses, including , where low levels predict worse outcomes independent of sun avoidance behaviors. Proponents of moderation argue that anti-sun messaging overstates non-melanoma risks relative to gains, noting epidemiological inconsistencies where lifelong sun exposure paradoxically associates with lower internal cancer rates and in some cohorts. A 2020 study demonstrated significant increases post-single sun bouts in both young and older adults, with no burns when exposure was calibrated to sub-erythemal doses. While UVB contributes to DNA damage, moderate protocols—exposing 25–50% body surface until slight pinkness fades—optimize synthesis without cumulative harm exceeding that from deficiency-related comorbidities. Critics of blanket sun avoidance, including Holick, contend that supplements fail to replicate sunlight's full photobiological effects, such as circadian regulation, underscoring endogenous production as evolutionarily preferred despite institutional preferences for dietary sources amid advocacy.

Regulations and Policy Responses

Classifications by Health Organizations

The International Agency for Research on Cancer (IARC), an arm of the (WHO), classified ultraviolet (UV) radiation-emitting tanning devices, such as sunbeds, as carcinogenic to humans () in July 2009, based on sufficient evidence linking their use to and other skin cancers. This classification aligns UV tanning devices with known carcinogens like and , emphasizing intentional exposure to artificial UV sources as a preventable . IARC also categorizes broad-spectrum UV , including from sources, as carcinogenic, though tanning classifications often highlight concentrated indoor exposures due to higher and lack of moderating factors like visible light. The U.S. (FDA) reclassified sunlamp products, including those used for , from low-risk Class I to moderate-risk Class II medical devices in June 2014, mandating premarket notification, special safety controls, and prominent warnings about cancer risks and skin damage. This regulatory shift requires manufacturers to demonstrate compliance with performance standards and informs users of UV-induced DNA damage leading to , premature aging, and eye injuries, reflecting empirical data on dose-dependent harms exceeding those from incidental sun exposure. The Centers for Disease Control and Prevention (CDC) does not issue a formal grouping but classifies as a modifiable risk factor for , recommending complete avoidance alongside sun protection to reduce incidence of , , and . CDC data link even limited sessions—such as one before age 35—to a 75% increased risk, positioning it as a concern comparable to other behavioral exposures. The (AAD) endorses IARC's designation for and advises against all forms of deliberate UV tanning, citing meta-analyses showing 20% higher odds per decade of use and elevated risks for non-melanoma skin cancers. AAD's position statement, informed by cohort studies, frames tanning—indoor or outdoor—as inherently risky due to cumulative UV-induced mutations, without endorsing "safe" levels for cosmetic purposes.
OrganizationClassificationKey BasisDate
IARC/WHOGroup 1 (Carcinogenic to humans) for UV-emitting tanning devicesEpidemiological evidence of skin cancer causation, including melanomaJuly 2009
FDAClass II medical device (moderate risk) for sunlamps/tanning bedsRequirement for safety controls due to burns, cancer, and eye risksJune 2014
CDCAvoid to prevent skin cancer (no formal group)Increased melanoma and non-melanoma risks from UV exposureOngoing, per 2024 guidelines
AADOppose all deliberate tanning; endorse Group 1 for indoorDose-response data on mutations and cancer incidencePosition since 2009
Several countries have enacted total bans on devices, citing health risks from () radiation classified as carcinogenic by the International Agency for Research on Cancer in 2009. implemented the world's first nationwide prohibition in 2009, outlawing the manufacture, import, sale, and use of tanning beds for , enforced through federal health agency oversight with penalties including fines and equipment confiscation. followed with a phased across states, completing the prohibition on solariums by 2018; enforcement involved mandatory decommissioning of devices, resulting in near-total compliance in public facilities, though private ownership for personal use remains legal and unregulated. also maintains a complete on operations. In , national laws predominate, with about half of countries imposing strict bans on tanning bed use for minors under 18, often without exceptions; for instance, prohibits access for those under 18 since 2009, enforced by local health authorities with fines up to €50,000 for operators. The has issued non-binding recommendations for risk warnings and minor restrictions, but enforcement varies by member state, typically through inspections and civil penalties rather than criminal sanctions. In the United States, federal oversight by the (FDA) classifies sunlamps and tanning devices as Class II medical devices since 1986, mandating warning labels on , eye damage, and burn risks, along with operational limits like maximum session times and protective requirements; non-compliance incurs civil fines up to $1,000 per violation or device seizure. State-level restrictions affect access: as of 2023, 44 states and the District of Columbia regulate or ban for minors, with 21 states enforcing outright prohibitions under age 18 and others setting limits at 14–16 with ; 18 states impose no age restrictions. Enforcement occurs via state health departments through routine inspections, with fines in 20 of 43 states with minor bans ranging from $50 to $25,000 per infraction, leading to variable compliance rates—higher in states with clear penalties but challenged by understaffed regulators and operator circumvention. Canada features provincial variations, such as full bans for minors under 18 in most jurisdictions, including since ; enforcement relies on units issuing fines up to $10,000 for salons, with low violation rates post-implementation due to public awareness campaigns. Globally, restrictions target commercial facilities to curb overuse, but natural sunlight exposure faces no legal limits, as it cannot be practically regulated.

Recent Developments

Post-2020 Research Findings

A 2021 meta-analysis of observational studies concluded that is associated with a of 1.20 (95% CI: 1.10-1.31) for overall and 1.45 (95% CI: 1.27-1.65) for early-onset diagnosed before age 40, based on data from over 27,000 cases. The analysis also linked to increased risks of non-melanoma skin cancers, including (RR 1.52, 95% CI: 1.09-2.13) and (RR 1.19, 95% CI: 1.04-1.37). These findings reinforce dose-response relationships, with greater risks for frequent or early-life exposure. Research on natural sun exposure has highlighted trade-offs between UV-induced DNA damage and vitamin D synthesis. A 2023 review emphasized that while excessive UV exposure elevates skin cancer incidence, moderate exposure—defined as 10-20 minutes of midday sun several times weekly for lighter skin types—optimizes serum 25(OH)D levels without proportionally increasing carcinogenesis in population studies. This aligns with causal mechanisms where UVB radiation (290-320 nm) converts 7-dehydrocholesterol to previtamin D3 in the skin, mitigating deficiency-linked conditions like osteoporosis and certain immune dysregulation. A 2025 pilot involving controlled UV exposure in 20 healthy adults demonstrated significant elevations in serum (mean increase of 25 nmol/L after four sessions) without inducing measurable inflammation or markers, suggesting short-term therapeutic potential under monitored conditions. Similarly, a 2022 randomized study in -insufficient individuals found that adding moderate sun exposure (15 minutes daily) to low-dose supplements raised 25(OH)D levels by 18-22 nmol/L more effectively than supplementation alone, supporting its role as a complementary . Emerging data question absolute risk attribution, noting that chronic, gradual sun exposure correlates with lower mortality in some cohorts compared to intermittent burns, potentially due to adaptive production and D-mediated anti-proliferative effects. However, indoor tanning's concentrated output (up to 12 times solar levels) lacks these natural regulators, amplifying via cyclobutane . Post-2020 epidemiological trends indicate persistent incidence rises in young adults, partly attributable to historical tanning behaviors, though factors like improved diagnostics complicate . In the early , cultural preferences shifted from valuing pale skin—associated with wealth and leisure indoors—to embracing tanned skin as a symbol of health, vitality, and outdoor affluence, catalyzed by figures like Coco Chanel's publicized yacht vacation in 1923 that popularized the "healthy glow." This reversal persisted through the mid-20th century, with icons such as and reinforcing tan aesthetics in media, linking it to glamour and sexuality. By the , the advent of commercial tanning beds amplified this trend, with peaking in popularity among Western consumers by the 1990s and early 2000s, often marketed as a year-round path to the coveted bronze. Health awareness campaigns from the onward, highlighting ultraviolet radiation's role in , prompted a marked decline in sunbathing and enthusiasm, evidenced by U.S. prevalence dropping from 14.1% in earlier surveys to 4.0% by recent national health data. Culturally, tan skin retains appeal for perceived attractiveness and confidence boosts, with surveys indicating over 50% of tanners citing improved and social perceptions. However, this has bifurcated into safer alternatives, with a resurgence in "sunless" methods amid broader beauty standards emphasizing skin health over risk; pale or natural complexions have gained traction in some circles as anti-aging ideals counter tan-induced concerns. Market dynamics reflect this pivot: the U.S. salon sector, valued at $1.9 billion in 2024, has seen modest 1.9% CAGR growth from 2019 amid regulatory pressures and disruptions that slashed visits by up to 84% in early 2020. Conversely, self-tanning products have surged, with the global market expanding from $1.16 billion in 2024 to a projected $1.99 billion by 2032 at a 7.9% CAGR, driven by formulations mimicking natural tans without UV exposure and integration into skincare routines. This growth underscores a consumer shift toward risk-mitigated , bolstered by and influencer endorsements prioritizing "glow without glow-down."

References

  1. [1]
    The Protective Role of Melanin Against UV Damage in Human Skin
    Tanning is determined directly by the response of melanocytes to UVR, but is also affected indirectly by a complex system of paracrine and autocrine factors ...
  2. [2]
    The Chemistry of Skin Tanning - Scientific Animations
    Apr 23, 2018 · Skin tanning or melanogenesis is a natural defense mechanism that is alerted against UV rays, through production of melanin pigment by melanocytes.
  3. [3]
    Section One- What Causes Tanning Of The Skin? | Utah County ...
    Tanning is caused by UV light exposure, which triggers melanocytes to produce melanin. The skin darkens to block harmful rays. Melanin production is limited ...
  4. [4]
    A Brief History of Tanning - FLESH WORLD by Jessica DeFino
    Sep 8, 2022 · Coco Chanel in particular popularized the tan in the 1920s. We're still seeing that today. People are tanning, people are self-tanning. Tanned ...
  5. [5]
    CHANGES in SKIN TANNING ATTITUDES Fashion Articles and ...
    Historical reviews suggest that tanning first became fashionable in the 1920s or 1930s. To quantitatively and qualitatively examine changes in tanning ...
  6. [6]
    2.1 The history of the tanning industry - AestheticsED
    In the 1970s, European scientist Friedrich Wolff founded the indoor tanning industry while studying the impacts of ultraviolet (UV) light on athletes.
  7. [7]
    From Sunlight to Sunless Tanners: the History of Our Obsession ...
    Jul 26, 2016 · The first modern indoor tanning bed was introduced in the U.S. in 1978. While paler skin had once been the mark of privilege, tanned skin now ...
  8. [8]
    Overview on vitamin D and sunbed use - PubMed
    Sunbeds can increase vitamin D levels, but are classified as carcinogens. Vitamin D supplementation is preferred over sunbed use due to the risk.
  9. [9]
    10 surprising facts about indoor tanning
    Getting enough vitamin D from tanning beds isn't possible. You may have heard that your body makes a lot of vitamin D when you use a tanning bed. It doesn't ...
  10. [10]
    Tanning - The Skin Cancer Foundation
    It's a fact: There is no such thing as a safe or healthy tan. Tanning increases your risk of basal cell carcinoma, squamous cell carcinoma and melanoma. Your ...
  11. [11]
    The Risks of Tanning - FDA
    May 16, 2023 · Evidence suggests that tanning greatly increases your risk of developing skin cancer. And, contrary to popular belief, getting a tan will not protect your skin.
  12. [12]
    An Epidemiological Update on Indoor Tanning and the Risk of Skin ...
    Nov 17, 2022 · A statistically significant higher risk of cutaneous melanoma, BCC and cSCC with the use of sunbeds has been consistently demonstrated.
  13. [13]
    Dangers of Tanning Beds - Skin Cancer Institute
    Using a tanning bed before age 35 increase a person's risk for melanoma by 75 percent. Tanning also causes: Premature aging of the skin.
  14. [14]
    Indoor tanning - American Academy of Dermatology
    Indoor tanning can increase users' risk of developing squamous cell carcinoma by 58% and basal cell carcinoma by 24%. · Higher melanoma rates among young females ...
  15. [15]
    How do sunbeds cause skin cancer? - Cancer Research UK
    Nov 30, 2023 · Sunbeds use high intensity UV radiation for quick tanning. UV radiation can damage the DNA in your skin cells. This can lead to skin cancer, including melanoma.
  16. [16]
  17. [17]
    Human skin pigmentation as an adaptation to UV radiation - PNAS
    May 5, 2010 · Tanning comprises two mechanisms, immediate pigment darkening (IPD) and the delayed tanning reaction (DTR). IPD involves an immediate darkening ...
  18. [18]
    Pigmentation effects of solar simulated radiation as compared ... - NIH
    UVA induces immediate tanning and persistent pigment darkening through oxidation of pre-existing melanin or melanogenic precursors, while UVB induces delayed ...
  19. [19]
    Skin Pigmentation and its Control: From Ultraviolet Radiation to ...
    Ultraviolet (UV) radiation is a unique modulator of skin pigmentation influencing tanning pathways. The delayed tanning pathway occurs as UVB produces ...Missing: peer- | Show results with:peer-
  20. [20]
    UV Radiation and the Skin - PMC - PubMed Central
    MC1R signaling protects the skin from UV damage by at least two major mechanisms. First, by inducing pigment synthesis in melanocytes, MC1R enhance production ...
  21. [21]
    Regulation of Human Skin Pigmentation in situ by Repetitive UV ...
    In contrast, UVB (280–320 nm) induces a slower but more stable type of pigmentation termed delayed tanning, which requires the increased synthesis of melanin ...<|separator|>
  22. [22]
    Human Skin Pigmentation as an Adaptation to UV Radiation - NCBI
    Tanning comprises two mechanisms, immediate pigment darkening (IPD) and the delayed tanning reaction (DTR). IPD involves an immediate darkening of the skin ...Missing: peer- | Show results with:peer-
  23. [23]
    The evolution of human skin pigmentation involved the interactions ...
    The evolution of partly depigmented skin and variable tanning abilities has occurred multiple times in prehistory, as populations have dispersed into ...
  24. [24]
    [PDF] The Evolution of Tanning Needs Its Day in the Sun
    Sep 1, 2015 · Facultative melanogenesis (tanning) is a photoprotective response triggered by DNA damage and repair following UVR exposure which can result in ...
  25. [25]
    The evolution of human skin pigmentation involved the interactions ...
    Under more highly seasonal UVR regimes, the evolution of enhanced tanning abilities and genes contributing to rapid development of facultative pigmentation has ...
  26. [26]
    Weakened tanning ability is an important mechanism for ...
    PAH is a potential pigmentation gene that regulates skin tanning ability. Natural selection has enriched the adaptive allele, resulting in weakened tanning ...
  27. [27]
    The colours of humanity: the evolution of pigmentation in ... - Journals
    May 22, 2017 · In this paper, we explore the diversity of skin, hair and eye coloration in the human lineage, and seek explanations for the evolution of pigmentation traits.Abstract · Human coloration in context · Variation in human skin... · Conclusion
  28. [28]
    The evolution of human skin pigmentation: A changing medley of ...
    Jun 25, 2022 · This review examines putative, yet likely critical evolutionary pressures contributing to human skin pigmentation and subsequently, depigmentation phenotypes.
  29. [29]
    The deceptive nature of UVA-tanning versus the modest protective ...
    UVB radiation. Skin Pharmacol. Appl. Skin Physiol. 2002;15:316–320. doi ... skin tanning. Biochem. Biophys. Res. Commun. 1987;142:265–274. doi: 10.1016 ...
  30. [30]
    Mechanisms of Skin Tanning in Different Racial/Ethnic Groups in ...
    Three potential mechanisms could explain the phenomenon of tanning following UV exposure: (1) redistribution of existing melanin towards the surface of the ...
  31. [31]
    Which Fitzpatrick skin type are you? - MedicalNewsToday
    Fitzpatrick skin typing is a way of classifying skin types. Types range from 1–6 depending on skin features and the risk of sunburn and skin cancer.
  32. [32]
    Fitzpatrick skin typing: Applications in dermatology
    ... sun exposure [Table - 1]. The two main factors that influence skin type are: Genetic disposition; Reaction to sun exposure and tanning habits. Skin type is ...Missing: natural | Show results with:natural
  33. [33]
    Self-Reported Pigmentary Phenotypes and Race are Significant but ...
    Fitzpatrick skin phototype (FSPT) is the most common method used to assess sunburn risk and is an independent predictor of skin cancer risk.Missing: natural | Show results with:natural
  34. [34]
    Sun Safety | Johns Hopkins Medicine
    Limit sun exposure, use broad-spectrum sunscreen with SPF 30+, wear protective clothing, seek shade, and avoid tanning beds.Sun Safety For The Entire... · What Is Ultraviolet... · How Can You Protect Yourself...
  35. [35]
    Your Skin | FDA
    May 16, 2023 · Factors such as age, health, and skin type all determine how an individual will be affected by UV exposure. People over the age of 50 and ...Missing: Fitzpatrick | Show results with:Fitzpatrick
  36. [36]
    Sunscreens and Photoprotection - StatPearls - NCBI Bookshelf - NIH
    Mar 28, 2025 · To be considered effective, sunscreens must have an SPF of at least 2, with higher SPF values recommended for extended sun exposure.
  37. [37]
    Beneficial effects of UV radiation other than via vitamin D production
    Due to the complexity of the disorder a lot of different treatments are recommended, including phototherapy with narrowband UVB radiation ... skin tanning and ...
  38. [38]
    Sunbeds and solaria - DermNet
    Sunbeds are artificial tanning devices used to tan or darken skin. They may be in the form of a lie-down bed or an upright cubicle that the user stands in.
  39. [39]
    Ultraviolet (UV) Radiation Tanning Equipment | US EPA
    Aug 28, 2025 · Sun lamps and tanning equipment mostly emit UVA rays. UVA rays are sometimes known as “tanning rays,” and are less likely to cause sunburn than ...
  40. [40]
    Ultraviolet emission spectra of sunbeds - PubMed
    Sunbed emission spectra are similar to the sun spectrum in the UVB (280-320 nm) range but reach values 10 to 15 times higher in the UVA (320-400 nm) range.
  41. [41]
    Sunlamps and Sunlamp Products (Tanning Beds/Booths) - FDA
    Sep 28, 2020 · The FDA wants consumers to know that UV radiation in tanning devices poses serious health risks. A 2009 report by the International Agency for ...Risks/Benefits · Information for the Public · Laws, Regulations & Standards
  42. [42]
    Sun 101: A history of tanning - Yahoo
    Jul 13, 2022 · Indoor tanning beds, the brainchild of German scientist Friedrich Wolff, were introduced to the United States in 1979 and were originally ...<|separator|>
  43. [43]
    The History of Tanning - ProSun International
    The indoor tanning industry came to America in the late 70s, boomed in the mid-80s. In 1987, tanning salons were the fastest growing US business, according to ...
  44. [44]
    Use of Indoor Tanning Devices by Adults — United States, 2010 - CDC
    May 11, 2012 · Indoor tanning is particularly dangerous for younger users because indoor tanning before age 35 years increases the risk for melanoma by 75% (1 ...
  45. [45]
    Who Still Indoor Tans in the United States? An Updated Analysis of ...
    Aug 10, 2025 · The overall prevalence of indoor tanning within the last year was 1.96% among females and 0.87% among males, a decrease from the most recently ...
  46. [46]
    Tanning Products | FDA
    Apr 26, 2019 · Tanning products include lamps, booths, beds, sunless sprays/lotions using DHA, and unsafe tanning pills not approved by the FDA.
  47. [47]
    Tanning - FDA
    May 21, 2019 · The FDA wants consumers to know that UV radiation in tanning devices poses serious health risks. A 2009 report by the International Agency for ...
  48. [48]
    In search of the perfect tan: Chemical activity, biological effects ...
    Dihydroxyacetone (DHA) has seen extensive use as the main tanning agent in sunless tanners. The DHA‐induced tan is a result of brown melanoidins formed by a ...
  49. [49]
    Dihydroxyacetone, tanning cream, sunless tanning - DermNet
    DHA is thought to penetrate the stratum corneum when applied topically, where it undergoes a Maillard reaction (non-enzymatic glycation) with free amino acids ...
  50. [50]
    Dihydroxyacetone - an overview | ScienceDirect Topics
    Dihydroxyacetone (DHA) is defined as a compound that stains the surface layers of the skin by covalently binding to free amine groups in keratin proteins, ...
  51. [51]
    Dihydroxyacetone: A Review - JDDonline
    Dihydroxyacetone (DHA) is a 3-carbon sugar allowed by the Food and Drug Administration (FDA) as a color additive in sunless tanning products.Missing: self- | Show results with:self-
  52. [52]
    Erythrulose (Explained + Products) - INCIDecoder
    Erythrulose is a fermentation-derived, natural keto-sugar used as a self-tanning active, providing a deep, even, long-lasting tan. It works slower than DHA but ...
  53. [53]
    The combination of DHA and erythrulose for a natural tan - Typology
    Feb 23, 2022 · A natural tan, achieved through the combination of dihydroxyacetone (DHA) and erythrulose. Thanks to self-tanners, it is now possible to achieve a sun-kissed ...
  54. [54]
  55. [55]
    A Review of Common Tanning Methods | JCAD
    ... UVB radiation has been correlated with the reduction of roughly 20 types of ... Sunless skin tanning with dihydroxyacetone delays broad-spectrum ultraviolet ...
  56. [56]
    Properties and safety of topical dihydroxyacetone in sunless tanning ...
    Sep 12, 2023 · Dihydroxyacetone (DHA) is a simple carbohydrate found nearly universally in sunless tanning products that serves to impart color to the skin.Missing: peer- | Show results with:peer-
  57. [57]
    [PDF] Exposure to Dihydroxyacetone in Sunless Tanning Products
    Mechanism of DHA Action. DHA, also known as glycerone or dihydroxy-2-propanone, is a three-carbon sugar (C3H6O3), which is often derived from plant sources ...<|separator|>
  58. [58]
    The benefits and risks of ultraviolet (UV) tanning and its alternatives
    Sun exposure should not be used as an alternative but as an adjunct to a diet fortified with vitamin D. Sunless tanning products may serve as a sensible, safer ...
  59. [59]
    Sunlight and Vitamin D: A global perspective for health - PMC
    During exposure to sunlight 7-dehydrocholesterol in the skin absorbs UV B radiation and is converted to previtamin D3 which in turn isomerizes into vitamin D3.
  60. [60]
    Biological Effects of Sunlight, Ultraviolet Radiation, Visible Light ...
    Healthy adults exposed to a tanning bed were reported to increase serum beta-endorphin levels by 44% (35). Beta-endorphin, an endogenous opioid peptide, has ...Missing: documented | Show results with:documented
  61. [61]
    Health Benefits of the Sun, Beyond Vitamin D - GrassrootsHealth
    May 4, 2020 · Furthermore, sensible exposure to sunlight actually protects the skin and deeper tissues from UV damage by increasing pigmentation (short term ...
  62. [62]
    Mechanisms of UV-induced mutations and skin cancer - PMC - NIH
    Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific mutations and the emergence of skin cancer in humans.
  63. [63]
    Mechanisms of UV-induced mutations and skin cancer
    Mar 19, 2020 · Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific mutations and the emergence of skin cancer in humans.
  64. [64]
    Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage ...
    In this review, we discuss the role of UV-induced DNA damage and oxidative stress in the skin stem cell aging in order to gain insights into the pathogenesis.
  65. [65]
    Indoor tanning and skin cancer in Canada: A meta-analysis and ...
    Ever use of indoor tanning devices was associated with relative risks of 1.38 (95% CI 1.22–1.58) for melanoma, 1.39 (1.10–1.76) for basal cell carcinoma (BCC), ...
  66. [66]
    Does UV Radiation Cause Cancer? | American Cancer Society
    Jun 26, 2024 · The risk of melanoma is about 60% higher if a person starts indoor tanning before age 35. And, the risk of basal and squamous cell skin cancer ...
  67. [67]
    Indoor UV tanning and skin cancer: health risks and opportunities
    All subtypes of use were found to be positively associated with melanoma risk, and risk was highest for individuals who began using tanning beds prior to age ...
  68. [68]
    Sun-damaged Skin: Photoaging, Signs, Causes & Treatment
    Ultraviolet (UV) radiation causes changes to the DNA in the cells of your skin. This can lead to premature skin aging (photoaging) and skin cancer. There are ...Missing: proven | Show results with:proven
  69. [69]
    Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by ...
    Use of tanning salons before the age of 35 years is associated with a 75% increased lifetime melanoma risk [47], therefore the increasing use of tanning beds ...
  70. [70]
    Ultraviolet radiation - World Health Organization (WHO)
    Jun 21, 2022 · Acute effects of UVR include DNA damage, sunburn, phototoxic and photoallergic reactions, and suppression of the immune system.Overview · Health Effects · Effects On The Skin
  71. [71]
    [PDF] Exposure to Artificial UV Radiation and Skin Cancer
    Both UVA and UVB radiation can affect the immune response that may be involved in the promotion of melanoma (Kripke, 1974; Singh et al., 1995), but the two ...
  72. [72]
    Moderate Sun Exposure Is the Complementor in Insufficient Vitamin ...
    Mar 7, 2022 · Studies have demonstrated that melanin in skin blocks UV radiation that is necessary for Vit D synthesis (59) and called for the higher need of ...
  73. [73]
    Benefits and Risks of Sun Exposure to Maintain Adequate Vitamin D ...
    May 5, 2023 · Moreover, indoor UV tanning beds did increase vitamin D production but are not recommended due to the higher risk of skin cancer and dermatoses ...
  74. [74]
    The effects of two different doses of ultraviolet-A light exposure ... - NIH
    Mar 7, 2018 · Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivatives.
  75. [75]
    The effect of daily UVA phototherapy for 2 weeks on clinic and 24-h ...
    Aug 5, 2022 · Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivates.
  76. [76]
    Impact of ultraviolet radiation on cardiovascular and metabolic ...
    Sep 20, 2023 · A randomized controlled trial revealed a reduction in blood pressure accompanied by an elevation in circulating nitrite levels and a ...
  77. [77]
    Indoor Tanning and Melanoma Risk: Long-Term Evidence From a ...
    Feb 1, 2017 · At that time, tanning devices with lamps rich in ultraviolet B (UVB) radiation were replaced by devices with ultraviolet A (UVA)-rich ...
  78. [78]
    Sun exposure and non-melanocytic skin cancer - PubMed
    The direct evidence linking sun exposure and skin cancer is weaker with few well-conducted studies of sun exposure in individuals.
  79. [79]
    Incidence of Nonmelanoma Skin Cancer in Relation to Ambient UV ...
    Aug 6, 2014 · Overall, a 1-kJ/m2 increase in ambient UVR was associated with a 67% increase in BCC incidence and a 95% increase in SCC incidence, with a ...
  80. [80]
    Benefits of moderate sun exposure - Harvard Health
    Jan 20, 2017 · Recent sun exposure doesn't seem to be associated with basal cell carcinoma, the mildest form of skin cancer. Squamous cell carcinoma appears to ...Missing: empirical | Show results with:empirical<|separator|>
  81. [81]
    Sunlight and skin cancer - PMC - NIH
    It is well known that chronic exposure to ultraviolet (UV) radiation present in sunlight is responsible for the induction of most nonmelanoma skin cancer ...
  82. [82]
    Patterns and timing of sunlight exposure and risk of basal cell and ...
    Sep 20, 2012 · Results from the current study suggest that sunlight exposure is associated with both BCC and SCC risk regardless of the pattern in which the exposure was ...
  83. [83]
    Sunscreen: a brief walk through history - PMC - NIH
    Sep 1, 2021 · 3100-300 bc: The ancient Egyptians use methods of sun protection for cosmetic reasons; lighter skin is more desirable culturally. The Egyptians ...
  84. [84]
    The Beauty Of Pale Skin In Ancient Greece - 393 Words - Bartleby.com
    In Ancient Greece, pale skin was a sign of prestige and beauty. It meant women didn't have to work for long periods of time in the fields to support themselves.
  85. [85]
    A short history of tanning | Sophie Wilkinson - The Guardian
    Feb 19, 2012 · Initially, pale skin was popular, then tanning became chic after Coco Chanel. Sunless tanning and sunbeds became popular, and by 2000, 50% of ...
  86. [86]
    Chasing the sun: a journey through the history of tanning
    Jun 23, 2023 · The concept of tanned skin has undergone a remarkable transformation throughout history, evolving from an association with labour and low social status.
  87. [87]
    Why Do We (Still) Tan? - The Skin Cancer Foundation
    Jun 20, 2023 · 1923 – Coco Chanel was famously bronzed after a trip to the French Rivera. 1929 – A swimwear brand begins to run ads with women not wearing any ...Missing: modern | Show results with:modern
  88. [88]
    More Skin, More Sun, More Tan, More Melanoma - PMC - NIH
    LATE 20TH CENTURY. The tanning trend that began in the 1920s sustained its allure and celebrity promotion into the late 20th century. Despite mounting evidence ...
  89. [89]
    Trends in Tanning: The Evolution of Tanning Culture
    Jan 4, 2024 · In the late 20th century, the tanning bed industry experienced a significant boom. Tanning salons became ubiquitous, offering an alternative to ...
  90. [90]
    Will a Tan Make You More Attractive? | Psychology Today
    Jul 17, 2020 · Participants indicated that models with a medium level tan appeared most attractive and healthiest, with those who had no tan appearing least ...
  91. [91]
    Cultural Perspectives on Tanning: Exploring Variations in Attitudes ...
    Apr 1, 2024 · While tanned skin has been traditionally revered in Western cultures as a symbol of health and leisure, preferences for fair skin persist in ...
  92. [92]
    The Influence of Appearance, Health, and Future Orientations on ...
    However, the literature suggests that the effect on perceived appearance is the primary motivation for sunbathing and tanning booth use.
  93. [93]
    Reasons for using indoor tanning devices: A systematic review of ...
    Jul 9, 2022 · Users of sunbeds were motivated primarily by aesthetic concerns but also by perceived psychological benefits (well-being, confidence and 'fitting in') and ...
  94. [94]
    Correlates of Intentional Tanning Among Adolescents in the United ...
    Social factors correlated with intentional tanning include parental influence (having a parent who tans or permits tanning) and peer influence (having friends ...
  95. [95]
    The role of body image and depression in tanning behaviors and ...
    Body image and depression were associated with tanning behaviors and attitudes. Results suggest that psychological factors are important motivators.
  96. [96]
    The relationship between skin tone dissatisfaction and sun tanning ...
    Both skin tone dissatisfaction and appearance reasons for tanning were significantly positively related to sun tanning behaviour. Fisher's t‐test for the ...<|separator|>
  97. [97]
    Prevalence of tanning addiction and associations with behavioral ...
    Tanning addiction was significantly associated with past 30-day smoking and marijuana use, problem substance use, depression, panic disorder, obsessive ...
  98. [98]
    Addiction to Indoor Tanning: Relation to Anxiety, Depression, and ...
    Students who met DSM-IV-TR and CAGE criteria for addiction to indoor tanning reported greater symptoms of anxiety and greater use of alcohol, marijuana, and ...<|control11|><|separator|>
  99. [99]
    Tanning as an Addiction: The State of the Research and Implications ...
    As we will describe, motivations driving tanning addiction may stem from psychological factors such as aesthetic and appearance norms (wanting to look tanned) ...
  100. [100]
    Critique of the International Agency for Research on Cancer's meta ...
    This meta-analysis of the association of CMM risk with respect to sunbed use by the IARC does not support the evidence that sunbed use is a risk factor for CMM ...
  101. [101]
    International Prevalence of Indoor Tanning A Systematic Review ...
    The summary prevalence of exposure to indoor tanning in the past year was 14.0% (95% CI, 11.5%-16.5%) for adults, 43.1% (21.7%-64.5%) for university students, ...
  102. [102]
    Ultraviolet radiation is not the major cause of melanoma mortality in ...
    Although there was a trend to increased incidence in melanoma with increased sun exposure, there was no rise in mortality.
  103. [103]
    Sunbeds and Melanoma Risk: Many Open Questions, Not Yet Time ...
    A large body of evidence from epidemiological and animal studies demonstrates no increase in melanoma risk after chronic (moderate) UV exposure (24-31). Many ...
  104. [104]
    Vitamin D: Production, Metabolism, and Mechanism of Action - NCBI
    Jun 15, 2025 · Vitamin D production in the skin under the influence of sunlight (UVB) is maximized at levels of sunlight exposure that do not burn the skin.
  105. [105]
    [PDF] Sunlight and Vitamin D Controversy Heats Up
    Jul 1, 2005 · Dr. Holick recommends 5-10 min- utes of sun exposure on the face and on the arms and legs.<|separator|>
  106. [106]
    How Sensible Sun Exposure Benefits Your Health - GrassrootsHealth
    May 30, 2022 · Dr. Michael Holick Provides a Detailed Review of the Health Benefits from Sensible Sunshine Exposure · Vitamin D is VITAL, and we know that ...
  107. [107]
    The Sunlight-Vitamin D Connection: Implications for Patient ...
    In the innate immune response, Vitamin D enhances the production of antimicrobial peptides like cathelicidins and defensins, which are essential for defence ...<|separator|>
  108. [108]
    Vitamin D and Sunlight: Strategies for Cancer Prevention and Other ...
    It is estimated that there is a 30 to 50% reduction in risk for developing colorectal, breast, and prostate cancer by either increasing vitamin D intake to ...
  109. [109]
    Malignant Melanoma: Vitamin D Status as a Risk and Prognostic ...
    This study demonstrates an association between low vitamin D status and both increased melanoma risk and worsened prognosis.
  110. [110]
    Skin cancer patients more likely to be deficient in vitamin D, study finds
    Oct 18, 2010 · Skin cancer patients who avoid the sun are three times more likely to be vitamin-D deficient than healthy people, according to a new study.
  111. [111]
    Should You Fear the Sun Because of Skin Cancer? The Real ...
    May 22, 2025 · Several studies conclude that regular, sensible, non-burning sun exposure throughout the lifetime, and higher vitamin D levels, are healthy for the skin.Key Points · Uvb Exposure On The Skin... · Lower Melanoma Risk With...
  112. [112]
    Vitamin D Synthesis Following a Single Bout of Sun Exposure ... - NIH
    Jul 27, 2020 · Conclusions: Serum D3 concentration increased significantly in response to outdoor sun exposure in younger and older adults. While ageing may ...
  113. [113]
    Vitamin D: Do We Need More Than Sunshine? - PMC - NIH
    Sunlight is unarguably the most optimal way to obtain vitamin D plus numerous other benefits. ... There are factors that affect UV radiation exposure and vitamin ...
  114. [114]
  115. [115]
    Media Centre – IARC News
    Jul 29, 2009 · Sunbeds and UV Radiation​​ An IARC Working Group has classified UV-emitting tanning devices as “carcinogenic to humans” (Group 1). The Working ...
  116. [116]
    Sunbeds and UV Radiation - IARC
    Jul 29, 2009 · An IARC Working Group has classified UV-emitting tanning devices as “carcinogenic to humans” (Group 1).
  117. [117]
    IARC moves sunbeds to highest cancer risk category - ecancer
    Aug 5, 2009 · A comprehensive meta-analysis concluded that the risk of skin melanoma is increased by 75% when use of tanning devices starts before 30 years ...
  118. [118]
    General and Plastic Surgery Devices: Reclassification of Ultraviolet ...
    Jun 2, 2014 · The Food and Drug Administration (FDA or the Agency) is reclassifying ultraviolet (UV) lamps intended to tan the skin from class I (general controls)
  119. [119]
    Sun Safety Facts | Skin Cancer - CDC
    Jul 1, 2024 · To lower your skin cancer risk, protect your skin from the sun and avoid tanning. ... Guidelines for School Programs to Prevent Skin Cancer.
  120. [120]
    Dangers of indoor tanning - American Academy of Dermatology
    Sep 22, 2023 · Studies have found that indoor tanning can increase users' risk of developing squamous cell carcinoma by 58% and basal cell carcinoma by 24%. To ...Missing: classification | Show results with:classification
  121. [121]
    [PDF] American Academy of Dermatology Commends Reclassification of ...
    Aug 17, 2009 · This classification places indoor tanning in the highest cancer risk category afforded by this international agency, which is a division of the ...
  122. [122]
    Global Tanning Bed Advertising: A Comparison of Legal ...
    Sep 1, 2023 · Regulations for the tanning bed industry vary internationally. Brazil and Iran were the first countries to introduce a total ban of tanning ...
  123. [123]
    Experience from an outright ban of commercial sunbeds in the ... - NIH
    May 4, 2022 · 24 countries prohibit sunbed use in persons aged under 18 years and three countries – Australia, Brazil and Iran – have a total ban on commercial sunbeds.
  124. [124]
    Tanning Bed Legislation for Minors: A Comprehensive International ...
    Eight countries do not have any legislation on tanning bed use, including, amongst others, Russia, where a ban for minors was part of a comprehensive ...
  125. [125]
    Legal regulations for sunbeds - Bundesamt für Strahlenschutz
    Jun 20, 2024 · According to the law, since August 2009, sunbeds in tanning studios, similar facilities or other public spaces may not be used by minors.
  126. [126]
    Health effects of sunbeds for cosmetic purposes
    The harmonised standard EN 60335-2-27:2013 sets out requirements for the safety of sunbeds, including limits for ultraviolet radiation emission, and the ...
  127. [127]
    Indoor Tanning Legislation: Here's Where We Stand
    tanning salons are completely banned in both countries— several other ...<|separator|>
  128. [128]
    Tanning Salon Compliance Rates in States With Legislation to ... - NIH
    Of the 43 states with tanning bans, only 20 laws mention specific fines, ranging from $50 up to $25 000 (most were in the $250-$1000 range). Eight laws state ...
  129. [129]
    Legislation Restricting Access to Indoor Tanning Throughout the World
    Jul 16, 2012 · Six states or territories in Australia restricted indoor tanning in all minors; a province and a region in Canada implemented youth tanning laws ...
  130. [130]
    Indoor Tanning and the Risk of Overall and Early-Onset Melanoma ...
    Nov 25, 2021 · We found that indoor tanning is associated with increased risk for early-onset melanoma and NMSC, and has a dose–response relationship with first exposure at ...
  131. [131]
    A pilot clinical trial to explore the effects of UV exposure on vitamin D ...
    Jul 2, 2025 · Clinical studies have demonstrated that UVB exposure effectively increases serum vitamin D concentrations, alleviating vitamin D deficiency.
  132. [132]
    Re: Skin cancer prevention and sunscreens - The BMJ
    Jul 25, 2025 · ... tanning bed increases risk of melanoma by 1.2 (1.08 – 1.34)9. Chronic sun exposure may not increase risk of mortality from melanoma8. Melanoma ...Missing: studies | Show results with:studies
  133. [133]
    Knowledge of the risks of ultraviolet radiation, sun exposure ...
    In fact, ever exposure to indoor tanning increases the risk of cutaneous melanoma by 20 %, and by 59 % when the first exposure is before 35 years of age ( ...
  134. [134]
    Indoor and Outdoor Tanning | Cancer Trends Progress Report
    While reduction of indoor tanning is estimated to significantly reduce melanoma, outdoor sun exposure is the primary modifiable melanoma risk factor and ...
  135. [135]
    History of Tanning - The SunShine Co.
    Pop culture has had a significant impact on the popularity of tanning throughout the years. 20th-century Hollywood icons like Elizabeth Taylor and Marilyn ...
  136. [136]
    How Tanning Culture Has Evolved | Skin Inc.
    Aug 4, 2023 · See how the culture of tanning has changed through the years to focus more on sun care and "safe tanning."
  137. [137]
    330 Indoor tanning frequency trends: Data from the National Health ...
    ... decrease in indoor tanners from 14.1% to 4.0%. The adjusted prevalences decreased significantly across all indoor tanning user frequencies, but this was ...
  138. [138]
    The Skin We Live in: Pigmentation Traits and Tanning Behaviour in ...
    Skin colour and tanning ability showed evidence of a strong association with thinking pale skin is unattractive, whereas individuals who experienced more ...
  139. [139]
    Tanning Salons in the US Market Size Statistics | IBISWorld
    The US tanning salon market size was $1.9bn in 2024, with a 1.9% growth rate in 2024 and a 1.9% CAGR between 2019 and 2024.
  140. [140]
    Evaluating the impact of the COVID‐19 pandemic and state ... - NIH
    Indoor tanning searches decreased by 57-84% in March 2020, while outdoor tanning peaked in summer 2020. Indoor interest varied with state restriction ...
  141. [141]
    Self-Tanning Products Market Size, Share, Trends, Growth, 2032
    The self-tanning products market size was valued at USD 1.16 billion in 2024 and is projected to grow from USD 1.22 billion in 2025 to USD 1.99 billion by 2032.<|separator|>
  142. [142]
    Self-tanning Products Market Size Report, 2022-2030
    The global self-tanning products market is expected to grow at a compound annual growth rate of 4.5% from 2022 to 2030 to reach USD 1.31 billion by 2030. Which ...