Fact-checked by Grok 2 weeks ago

Vocal cord dysfunction

Vocal cord dysfunction (VCD), also known as paradoxical vocal fold motion (PVFM) or inducible laryngeal obstruction (ILO), is a functional disorder characterized by the inappropriate adduction or closure of the vocal cords during inhalation, resulting in partial airway obstruction and episodic breathing difficulties that frequently mimic asthma symptoms.^[1]^[2]^[3] This condition arises from laryngeal hyperresponsiveness, where the vocal folds fail to open properly, leading to restricted airflow primarily during inspiration, unlike the expiratory obstruction seen in asthma.^[3] VCD is not associated with an allergic or immune-mediated response and can occur alone or coexist with conditions like asthma, affecting quality of life through sudden, distressing episodes.^[4] The primary symptoms of VCD include sudden onset of shortness of breath, inspiratory wheezing or stridor, throat tightness, hoarseness, coughing, and a sensation of choking or inability to inhale sufficiently, often resolving quickly once the episode passes.^[4]^[2] These episodes are typically triggered by exercise, inhaled irritants (such as smoke, strong odors, or cold air), upper respiratory infections, gastroesophageal reflux disease (GERD), psychological stress, or anxiety, with symptoms more pronounced during inhalation compared to exhalation.^[1]^[5] Epidemiologically, VCD shows a female predominance (ratio of 2:1 to 3:1), with a median age of onset around 14 years in pediatric cases and 36 years in adults, and it may affect up to 50% of individuals previously diagnosed with refractory asthma.^[3] Diagnosis of VCD requires a high index of suspicion, as it is often misdiagnosed as asthma, leading to delayed recognition averaging 4 to 9 years; key diagnostic tools include flexible fiberoptic laryngoscopy to visualize paradoxical vocal cord movement during symptoms, spirometry showing a flattened inspiratory flow-volume loop, and exclusion of other causes through history and physical examination.^[4]^[3]^[5] Treatment focuses on non-pharmacologic interventions, with speech-language therapy and respiratory retraining techniques—such as pursed-lip breathing, panting maneuvers, or biofeedback—serving as the mainstay to teach patients to relax and control vocal cord function during episodes.^[2]^[1] Management of underlying triggers, including GERD treatment or psychotherapy for stress-related cases, is essential, while acute episodes may respond to heliox or anxiolytics; unlike asthma, bronchodilators provide little benefit.^[4]^[3] The prognosis is generally favorable, with VCD being a benign, self-limited condition that improves with early intervention and education, reducing unnecessary healthcare utilization.^[3]

Background

Definition

Vocal cord dysfunction (VCD), also known as paradoxical vocal fold motion (PVFM) or inducible laryngeal obstruction (ILO), is a condition characterized by the inappropriate adduction (closure) of the vocal folds during the inspiratory phase of respiration, resulting in transient upper airway obstruction.^[3]^[4]^[6] This paradoxical movement occurs when the vocal folds, which normally abduct (open) during inhalation to facilitate airflow, instead close abnormally, often in response to triggers but without underlying structural damage to the larynx.^[7]^[2] Unlike true vocal cord paralysis, in which one or both vocal folds fail to move due to nerve damage or neuromuscular impairment, VCD involves episodic, paradoxical motion where the vocal folds actively adduct despite intact innervation and mobility.^[8]^[9] This distinction highlights VCD as a functional disorder rather than a paralytic one, with episodes typically resolving spontaneously or with intervention.^[3] The terminology for VCD has evolved significantly since its initial descriptions in the early 20th century, reflecting a shift from psychogenic attributions to recognition of its non-volitional, multifactorial nature. Early terms such as "hysteric croup," "Munchausen's stridor," and "emotional laryngeal wheezing" emphasized supposed psychiatric origins, as seen in case reports from the 1970s.^[3]^[10] Modern nomenclature, including PVFM and ILO, underscores the inducible and physiological aspects of the condition, moving away from stigmatizing labels to focus on laryngeal mechanics.^[6]^[11]

Normal vocal cord function

The vocal folds, also known as vocal cords, are paired mucosal folds located within the glottis region of the larynx, positioned horizontally between the thyroid and cricoid cartilages and attached to the vocal processes of the arytenoid cartilages via the vocal ligament.^[12] They consist of five distinct layers arranged from deep to superficial: the thyroarytenoid muscle, which forms the primary muscular body; the deep and intermediate lamina propria, which together constitute the vocal ligament providing tensile strength; the superficial lamina propria, a gelatinous layer that facilitates smooth vibration; and the overlying stratified squamous epithelium, which protects the underlying structures.^[12] This multilayered structure, supported by the intrinsic laryngeal muscles such as the thyroarytenoid and cricothyroid, enables precise control over airway dynamics and sound production.^[12] During normal respiration, the vocal folds exhibit coordinated abduction and adduction to maintain unobstructed airflow. Inhalation involves the posterior cricoarytenoid muscles abducting the folds, rotating the arytenoid cartilages laterally to widen the glottis and allow air to enter the trachea and lungs without resistance.^[13] Conversely, during exhalation, the folds typically adduct slightly via the lateral cricoarytenoid, interarytenoid, and thyroarytenoid muscles to facilitate controlled airflow, though they remain sufficiently open for quiet breathing.^[13] This rhythmic opening and closing is synchronized with the respiratory cycle, driven by subglottal pressure from lung expansion and contraction, ensuring efficient gas exchange while minimizing energy expenditure.^[14] In voice production, the vocal folds play a central role by vibrating to generate sound during expiration. As air from the lungs flows through the partially adducted glottis, the resulting Bernoulli effect and subglottal pressure cause the folds to oscillate rapidly—typically 100 to 1,000 times per second—producing a mucosal wave that propagates from the inferior to superior surfaces and modulates airflow into acoustic waves.^[13] This vibration, initiated when subglottal pressure exceeds the phonation threshold, creates the fundamental frequency of the voice, which can be adjusted for pitch and intensity through variations in muscle tension and airflow.^[14] The process is finely tuned by the recurrent laryngeal nerve, a branch of the vagus nerve (cranial nerve X), which innervates all intrinsic laryngeal muscles except the cricothyroid (supplied by the superior laryngeal nerve), enabling precise adduction, abduction, and tension control.^[15] Laryngeal innervation integrates seamlessly with respiratory muscles, such as the diaphragm and intercostals, to coordinate vocal fold movements with overall breathing patterns. The recurrent laryngeal nerve provides motor input to the thyroarytenoid, lateral cricoarytenoid, and interarytenoid muscles for adduction and stiffening, while the posterior cricoarytenoid handles abduction, ensuring the glottis opens appropriately during inspiration to support both ventilation and subsequent phonation.^[15] This neural coordination, originating from the brainstem's nucleus ambiguus, allows for automatic adjustments during speech or singing, balancing airway patency with sound generation without compromising respiratory efficiency.^[13]

Clinical Features

Symptoms

Vocal cord dysfunction (VCD) presents with acute episodes of paradoxical vocal cord adduction during inspiration, leading to partial upper airway obstruction and respiratory distress.^[3] Primary acute symptoms include sudden onset of inspiratory stridor—a high-pitched, wheezing-like sound during inhalation—accompanied by dyspnea or shortness of breath, throat tightness, and a sensation of choking or inability to inhale adequately.^[7]^[16] These symptoms often feel like the throat is closing or that one is being strangled, with noisy breathing originating from the larynx rather than the lower airways.^[7]^[3] Associated sensations during episodes frequently involve frequent throat clearing, chest tightness, lightheadedness, and heightened anxiety, which can exacerbate the perceived urgency of the distress.^[7]^[3] Patients may also report hoarseness, dysphonia, or intermittent voice changes, along with a globus sensation—a feeling of something stuck in the throat—or difficulty swallowing.^[3] Tachypnea and visible use of accessory neck or chest muscles may occur, but severe signs such as cyanosis or profound hypoxia are typically absent, as oxygen saturation is generally maintained despite the subjective air hunger.^[3]^[4] Episodes of VCD are characteristically episodic and self-limited, with abrupt onset and resolution, often lasting from seconds to a few minutes—typically under 2 to 5 minutes in median duration.^[16]^[17] They resolve spontaneously without intervention in most cases, distinguishing them from progressive respiratory conditions.^[16] In chronic patterns, VCD manifests as recurrent episodes that closely mimic asthma attacks, leading to frequent emergency department visits and misdiagnosis in up to 85% of chronic cases, where symptoms persist despite asthma treatments.^[3] These recurrent events can include intermittent aphonia, chronic cough, fatigue, and throat clearing between acute flares.^[3] Symptoms may be briefly exacerbated by comorbid conditions such as asthma or gastroesophageal reflux disease.^[4]

Associated conditions

Vocal cord dysfunction (VCD) often coexists with respiratory conditions, particularly asthma, with up to 50% of individuals diagnosed with VCD also having concomitant asthma, leading to diagnostic challenges due to overlapping symptoms such as wheezing.^[18]^[19]^[3] Exercise-induced bronchoconstriction is another common association, where VCD episodes are triggered by physical exertion and may mimic or exacerbate this condition in athletes, affecting an estimated 5% of elite athletes.^[18]^[19] Gastrointestinal disorders are frequently linked to VCD, with gastroesophageal reflux disease (GERD) serving as a key irritant trigger that can provoke paradoxical vocal fold motion. Laryngopharyngeal reflux (LPR), a variant of reflux affecting the upper airway, is similarly associated, contributing to laryngeal irritation and VCD symptoms through direct mucosal damage.^[20]^[21] Psychological factors play a significant role in VCD comorbidities, including anxiety disorders and stress-related somatic symptoms, which are reported in a substantial proportion of cases.^[7] Conversion disorder is also commonly observed, with one study finding that 40% of VCD patients exhibited a conversion profile, and psychiatric conditions present in 45 out of 48 reviewed cases.^[3] Other associations include rhinitis and post-nasal drip, which act as irritants exacerbating VCD episodes.^[7] Vocal abuse is prevalent among performers and athletes, where overuse during singing, speaking, or intense training contributes to the development or worsening of VCD.^[22] Rare links exist to neurological conditions, such as laryngeal dystonia, though these are more often considered in differential diagnoses rather than direct comorbidities.^[23]^[21]

Pathophysiology

Causes

Vocal cord dysfunction (VCD), also known as paradoxical vocal fold motion, is a multifactorial condition involving a combination of physiological, environmental, and neurological factors that lead to inappropriate adduction of the vocal folds during respiration. The underlying etiology is complex, often encompassing laryngeal hyperresponsiveness characterized by heightened sensitivity of laryngeal sensory receptors and exaggerated glottic closure reflexes in response to various stimuli.^[3] This hyperresponsiveness is thought to arise from central nervous system dysregulation of laryngeal muscle control, including altered brainstem reflexes and autonomic balance that fail to coordinate normal inspiratory abduction.^[10] Irritant-induced mechanisms play a significant role, where exposure to extrinsic irritants such as smoke, chemicals, odors, or allergens triggers a protective reflex adduction of the vocal folds via sensory nerve stimulation. Intrinsic irritants, including gastroesophageal reflux disease (GERD) and postnasal drip from rhinitis, can similarly accentuate this reflex by causing chronic laryngeal inflammation and sensitization.^[3] Recent research as of 2025 has also identified protracted shortness of breath following SARS-CoV-2 and other respiratory infections as a trigger for VCD episodes.^[24] In these cases, the larynx responds paradoxically to perceived threats, leading to airflow obstruction despite no structural damage.^[25] Exercise-related triggers often manifest during periods of high ventilatory demand, such as in athletes or military personnel, where rapid breathing may provoke a hypersensitivity response in the larynx, resulting in paradoxical adduction. This is not limited to specific sports but is commonly reported in up to 12% of individuals with exertional dyspnea in high-performance settings.^[10] Neurologically, impaired sensorimotor control contributes, potentially involving vagal nerve hypersensitivity that amplifies sensory input from the recurrent laryngeal nerve, though VCD is not primarily psychogenic and stress acts mainly as an exacerbating factor rather than a root cause.^[3] Rare associations with central neurological conditions, such as Arnold-Chiari malformation, further highlight dysregulated neural pathways in laryngeal function.^[10]

Risk factors

Vocal cord dysfunction exhibits a strong demographic predisposition, primarily affecting females with a reported female-to-male ratio of approximately 3:1.^[26] This condition is most prevalent among adolescents and young adults, with a peak incidence between the ages of 20 and 40 years, though cases have been documented across a wide age range from children to older adults.^[26]^[27] Occupational and environmental factors contribute significantly to susceptibility, particularly in individuals exposed to respiratory irritants or engaging in vocally or physically demanding activities. Athletes, such as swimmers exposed to chlorinated environments and runners participating in endurance sports, face elevated risk due to exercise-induced triggers.^[2]^[28] Similarly, professions involving irritant exposure, like firefighters encountering smoke and toxins, increase vulnerability.^[29] Performers, including singers, are also at higher risk from chronic environmental stressors in performance settings.^[30] A history of certain medical conditions further heightens the likelihood of developing vocal cord dysfunction. Up to 50% of affected individuals have a prior or concomitant diagnosis of asthma, often leading to initial misdiagnosis.^[27] Untreated gastroesophageal reflux disease (GERD) serves as a key predisposing factor by causing chronic laryngeal irritation.^[31] Additionally, a background of psychological stress, anxiety disorders, or related conditions such as depression is commonly associated, potentially exacerbating susceptibility through behavioral and physiological pathways.^[26]^[32] Behavioral patterns that involve vocal or respiratory strain can predispose individuals to the condition. Frequent vocal overuse, such as prolonged singing, shouting, or speaking in noisy environments, contributes to increased risk among performers and others in demanding vocal roles.^[7] Poor breathing habits, often linked to habitual upper chest breathing or inadequate diaphragmatic support, may also play a role in susceptible populations.^[27]

Diagnosis

Clinical evaluation

The clinical evaluation of vocal cord dysfunction (VCD) begins with a detailed history taking to identify characteristic episodic symptoms and contextual factors. Patients typically report sudden-onset, short-duration episodes of dyspnea or throat tightness, often triggered by exercise, irritants such as strong odors or cold air, or psychological stressors like anxiety.^[16] A key historical clue is the lack of improvement or paradoxical worsening with asthma medications, such as inhaled bronchodilators, distinguishing VCD from reactive airway diseases.^[3] Clinicians should inquire about the location of discomfort (e.g., throat rather than chest), associated noisy breathing, and self-resolution within minutes, as these features help differentiate VCD from continuous respiratory issues.^[33] Physical examination is often unremarkable between episodes but can reveal critical signs during an acute attack. Findings may include inspiratory stridor, tachypnea, use of accessory respiratory muscles, and suprasternal retractions, reflecting upper airway obstruction.^[16] Patients may exhibit anxiety or point to the throat as the source of distress, with subtle signs like neck tension or altered voice pitch occasionally present.^[33] Between episodes, the exam is typically normal, underscoring the episodic nature of VCD.^[3] Initial pulmonary function testing supports the clinical suspicion by demonstrating patterns consistent with variable extrathoracic airflow obstruction. Spirometry performed during or shortly after symptoms often shows truncation or flattening of the inspiratory limb of the flow-volume loop, with an elevated ratio of forced expiratory flow at 50% vital capacity to forced inspiratory flow at 50% vital capacity (FEF50/FIF50 >1), though with variable sensitivity.^[16]^[34] Peak flow monitoring, particularly with patient-held devices during daily activities or triggers, can capture variability in inspiratory flows, aiding in real-time assessment without requiring specialized provocation.^[3] Red flags warranting urgent evaluation include features suggestive of life-threatening conditions such as anaphylaxis (e.g., associated rash, hypotension) or foreign body aspiration (e.g., sudden complete airway closure), necessitating immediate airway management and exclusion of these entities before attributing symptoms to VCD.^[33] High rates of emergency department visits or intubation history in refractory cases further highlight the need for prompt, thorough assessment to prevent misdiagnosis.^[16]

Confirmatory tests

Confirmatory tests for vocal cord dysfunction (VCD), also known as inducible laryngeal obstruction (ILO), aim to directly visualize or objectively measure abnormal vocal cord motion during symptomatic episodes, as the condition is episodic and functional in nature. The gold standard is laryngoscopy performed under conditions that provoke symptoms, supplemented by pulmonary function tests to identify characteristic airflow patterns, though the latter have poor sensitivity and specificity.^[34] Imaging and electromyography play limited roles, primarily to rule out structural or neuropathic causes when clinical suspicion warrants. According to the 2017 joint European Respiratory Society (ERS) and European Laryngological Society (ELS) statement, direct laryngoscopic examination during symptoms is the only objective method for anatomical diagnosis.^[34] Laryngoscopy, particularly flexible fiberoptic laryngoscopy, provides direct visualization of the larynx and is considered the definitive confirmatory procedure when conducted during an acute episode. The test involves inserting a thin, flexible endoscope through the nose to the vocal cords, often with patient cooperation to avoid sedation that could mask findings. Characteristic observations include paradoxical adduction of the anterior two-thirds of the vocal cords during inspiration, leaving a posterior diamond-shaped chink in the glottis, which confirms the diagnosis in nearly 100% of symptomatic cases. If symptoms are not present at the time of examination, provocation maneuvers such as panting, deep breathing, irritant exposure, or exercise can elicit the abnormal motion; for exercise-induced cases, continuous laryngoscopy during exercise (CLE) allows real-time monitoring of supraglottic or glottic narrowing exceeding 50% during inspiration.^[35] Rigid laryngoscopy may be used in select settings for better resolution, though flexible approaches are preferred for tolerability. The CLE test is widely used, involving protocols on a treadmill or bicycle to provoke symptoms.^[34] Pulmonary function tests, including spirometry with flow-volume loop analysis, offer supportive evidence by demonstrating variable extrathoracic upper airway obstruction, though they are not diagnostic alone due to their inconsistency outside symptomatic periods and overall poor sensitivity. A key finding is truncation or flattening of the inspiratory limb of the flow-volume loop, reflecting inspiratory flow limitation, which may be observed during or shortly after attacks. Methacholine challenge testing may provoke VCD symptoms in some cases but has limited diagnostic utility, low sensitivity, and does not reliably differentiate VCD from asthma.^[34] These tests are readily available and non-invasive, guiding the need for laryngoscopy. Imaging modalities such as computed tomography (CT) or magnetic resonance imaging (MRI) are rarely employed for VCD confirmation due to limited availability and radiation concerns but may be considered to exclude structural lesions like tumors or edema when laryngoscopy is inconclusive. Dynamic four-dimensional CT of the larynx assesses vocal cord motion by measuring luminal area reduction greater than 40% during over 70% of the respiratory cycle and can identify VCD in difficult-to-treat asthma cases, but it has limitations such as supine positioning and radiation exposure, potentially reducing the need for invasive laryngoscopy in appropriate candidates.^[34] MRI offers similar dynamic evaluation without radiation but is less commonly used owing to cost and scan duration. Electromyography (EMG) of the laryngeal muscles is uncommon for VCD diagnosis, as the disorder is typically functional rather than neuropathic, but it may be indicated in atypical cases suspecting recurrent laryngeal nerve involvement or neuromuscular disorders. The procedure involves needle electrode insertion into muscles like the thyroarytenoid and cricothyroid to record electrical activity during phonation and rest, helping differentiate true paralysis from fixation or other immobility. Laryngeal EMG is safe and reliable for evaluating vocal fold immobility but lacks established utility in confirming paradoxical motion specific to VCD.

Differential diagnosis

Vocal cord dysfunction (VCD) is frequently misdiagnosed due to overlapping symptoms with various respiratory, upper airway, and psychogenic conditions, necessitating careful differentiation through clinical history, laryngoscopy, and pulmonary function tests.^[36] A key feature of VCD is paradoxical vocal cord adduction during inspiration, leading to inspiratory stridor and airflow obstruction, which contrasts with many mimics.^[3] Among respiratory mimics, asthma is the most common confounder, as both can present with dyspnea and wheezing; however, asthma typically involves expiratory airflow limitation due to bronchial constriction, whereas VCD causes variable extrathoracic obstruction primarily on inspiration, often showing poor or no response to bronchodilators.^[3] Vocal cord paralysis, often resulting from recurrent laryngeal nerve injury such as post-thyroidectomy, differs by producing unilateral hoarseness and reduced or absent cord mobility on laryngoscopy, without the paradoxical movement seen in VCD.^[36]^[21] Upper airway conditions like laryngospasm, triggered by irritants such as gastroesophageal reflux or intubation, involve acute, sustained vocal cord closure but lack the intermittent, exercise- or stress-induced episodes characteristic of VCD, with laryngoscopy revealing the closure pattern.^[3] Subglottic stenosis, often post-intubation or from autoimmune diseases, causes fixed narrowing and persistent stridor, distinguishable from VCD's functional nature via imaging or endoscopy showing structural lesions rather than dynamic adduction.^[21] Foreign body aspiration presents with sudden-onset unilateral symptoms and may require bronchoscopy for confirmation, unlike the bilateral, reversible obstruction in VCD.^[36] Psychogenic and cardiac mimics include panic attacks, which feature hyperventilation and subjective dyspnea without true stridor or laryngoscopic abnormalities, often linked to anxiety triggers.^[3] Heart failure may simulate exertional dyspnea but lacks inspiratory stridor and shows cardiac-specific findings like edema or elevated BNP levels, with no vocal cord involvement on examination.^[36] Laryngoscopy during symptoms remains the gold standard differentiator for VCD, demonstrating anterior-posterior or adductory vocal cord closure, while flow-volume loops may show inspiratory flattening not responsive to therapy.^[21]

Treatment

Speech and breathing therapy

Speech and breathing therapy serves as the cornerstone of non-invasive treatment for vocal cord dysfunction (VCD), focusing on retraining respiratory patterns and laryngeal control to alleviate paradoxical vocal fold adduction during inhalation.^[37] Speech-language pathologists (SLPs) typically deliver these interventions, emphasizing self-management strategies that patients can apply during acute episodes or triggers.^[31] This approach aims to reduce laryngeal tension, promote efficient airflow, and prevent symptom escalation without reliance on medications.^[38] Key techniques in speech-language pathology include relaxed-throat breathing, where patients inhale gently through the nose with the throat and jaw relaxed to minimize vocal fold closure, often practiced in short sessions to build awareness of laryngeal position.^[31] Pant-lip breathing, involving rapid, shallow panting through slightly parted lips while keeping the glottis open, helps interrupt acute episodes by increasing glottic aperture and reducing adduction.^[37] Lip trill exercises, produced by vibrating the lips during exhalation on a sustained pitch, further aid in releasing tension around the larynx and improving breath coordination, particularly for patients with co-occurring voice strain.^[31] Breathing retraining complements these methods by targeting diaphragmatic engagement and nasal airflow to counteract upper chest breathing patterns that exacerbate VCD. Diaphragmatic breathing encourages deep abdominal expansion on inhalation, followed by controlled exhalation, which lowers overall respiratory effort and laryngeal hyperfunction.^[38] Nasal inhalation techniques, such as sniffing gently through the nose to promote vocal fold abduction, are integrated to reduce reliance on mouth breathing and associated tension.^[31] These exercises are often introduced progressively, starting in supine positions for better diaphragmatic control before advancing to upright or activity-based practice.^[37] Biofeedback enhances therapy by providing real-time visual or auditory cues to monitor and adjust vocal fold movement, commonly using flexible nasolaryngoscopy during simulated triggers like exercise.^[39] Patients observe their laryngeal dynamics on a screen, learning to maintain an open glottis, which reinforces self-regulation skills.^[38] This modality is particularly useful for athletes or those with exercise-induced VCD, allowing targeted adjustments under stress.^[39] Clinical studies demonstrate substantial efficacy, with speech therapy yielding symptom improvements in 68-76% of patients across pediatric and adult cohorts, often within 4-6 sessions focused on technique mastery and home practice.^[38] A systematic review of non-pharmacological interventions reported positive outcomes in 76% of measures, including reduced attack frequency by up to 62% and improved laryngeal imaging in 56% of cases, underscoring the role of consistent application in achieving long-term self-management.^[40] Overall, these therapies empower patients to interrupt episodes proactively, with sustained benefits when psychological triggers are briefly acknowledged in session planning.^[37]

Medical management

Medical management of vocal cord dysfunction (VCD) primarily involves addressing underlying comorbidities and providing targeted interventions for acute episodes or refractory cases, as there are no disease-specific pharmacological agents. Treatment of associated conditions such as gastroesophageal reflux disease (GERD) and allergic rhinitis is essential, as these can trigger or exacerbate VCD symptoms. For GERD, proton pump inhibitors (PPIs) are commonly prescribed to reduce acid reflux and laryngeal irritation, with one case series of 100 patients showing that 59% had comorbid GERD managed with PPIs alongside other therapies.^[41] Similarly, allergic rhinitis, present in up to 80% of VCD cases, is treated with antihistamines to alleviate nasal inflammation and postnasal drip that may irritate the larynx.^[41] In acute settings, particularly during severe episodes mimicking asthma exacerbations, non-invasive options aim to reduce airflow resistance without intubation. Heliox, a helium-oxygen mixture (typically 70:30 or 60:40), is administered via face mask or nebulizer to decrease turbulent flow through the narrowed glottis, providing rapid symptomatic relief in many patients.^[31] Ketamine, given as a sub-dissociative dose (e.g., 0.15 mg/kg intravenously), is reserved for rare, refractory cases unresponsive to initial measures, as it induces muscle relaxation without significant respiratory depression; a case report demonstrated successful resolution of paradoxical vocal cord motion with this approach.^[42] Inhaled agents play a limited role in VCD management, as the condition is not primarily bronchospastic. Ipratropium bromide, an anticholinergic, may offer adjunctive benefit in cases with coexisting bronchospasm or exercise-induced symptoms, with one small series reporting symptom improvement in six patients pretreated before exertion.^[31] However, beta-agonists like albuterol are generally ineffective and should be avoided to prevent unnecessary escalation. For refractory VCD unresponsive to conservative measures, procedural interventions provide temporary relief by interrupting the cycle of paradoxical adduction. Botulinum toxin type A injection into the vocal folds, typically 1.75-5.5 units per side via electromyography-guided laryngoscopy, induces selective paralysis of the thyroarytenoid muscles, reducing glottic obstruction for 3-6 months; a retrospective study of 13 patients showed significant symptom reduction in 85% with no major complications.^[43]

Psychological interventions

Psychological interventions for vocal cord dysfunction (VCD) primarily target the stress-related and psychosomatic components that can trigger or exacerbate episodes, often integrating cognitive and behavioral strategies to address anxiety and maladaptive perceptions of symptoms. These approaches recognize that VCD is frequently associated with psychological comorbidities such as anxiety disorders, and they aim to reframe episode perceptions and enhance coping mechanisms.^[38] Cognitive behavioral therapy (CBT) is a key intervention used to manage anxiety triggers and reframe perceptions of VCD episodes, helping patients identify and modify thought patterns that contribute to laryngeal tension. In a study of 36 adolescents, a four-session CBT program incorporating diaphragmatic breathing and cognitive restructuring led to significant reductions in symptom severity and functional disability, with improved self-reported control over symptoms. This approach has shown promise in pediatric and adolescent populations, where it addresses the psychosomatic elements often linked to stress-induced VCD.^[44]^[38] Stress management techniques, including mindfulness, relaxation training, and hypnosis, are employed to promote laryngeal control by reducing overall physiological arousal and muscle tension. Hypnosis, particularly self-hypnosis, has demonstrated effectiveness in resolving symptoms; for instance, in a series of 22 adolescents, 18 achieved full resolution within one month through guided self-hypnosis sessions focused on relaxation and symptom visualization. Biofeedback-assisted relaxation has also been effective in select cases, such as reducing supraglottic muscle tension by over 60% in an adolescent patient, thereby alleviating VCD episodes triggered by stress. Mindfulness-based practices, while more broadly studied for voice disorders, support stress reduction in VCD by fostering awareness of triggers without exacerbating anxiety.^[38] A multidisciplinary approach integrates these psychological interventions with speech therapy to address the psychosomatic components of VCD, ensuring comprehensive management of both mental and functional aspects. In a cohort of 14 pediatric patients, combining psychiatric treatments like biofeedback and hypnosis with speech therapy resulted in 100% symptom improvement. Similarly, a single-institution study of 22 patients using a team-based model (including psychological evaluation) reported symptom improvement in 86.4% of cases, highlighting the value of this integrated strategy in reducing misdiagnosis as a purely functional disorder.^[45] Evidence indicates that psychological interventions improve outcomes in 60-70% of stress-associated VCD cases, with reductions in anxiety and helplessness reported in over two-thirds of treated patients, underscoring their role in enhancing overall symptom control and quality of life.^[46]^[38]

Prognosis and Epidemiology

Prognosis

The prognosis for vocal cord dysfunction (VCD) is generally favorable, with most patients achieving significant symptom control through appropriate interventions such as speech therapy and trigger management.^[26] In one retrospective study of 49 patients, 26 out of 28 contacted individuals reported complete absence of symptoms, with follow-up durations ranging from 1 week to 5 years (median 5 months), indicating a high rate of resolution or effective control.^[47] Recurrence rates remain low when underlying triggers are identified and addressed, though spontaneous resolution is common in benign cases.^[3] Early diagnosis plays a crucial role in improving outcomes by preventing prolonged misdiagnosis and enabling timely multidisciplinary care, which has been associated with reduced healthcare utilization, including 57% fewer emergency department visits and 52% fewer clinic visits in treated cohorts.^[25]^[33] Conversely, persistent comorbidities such as gastroesophageal reflux disease (GERD) or anxiety can worsen prognosis by exacerbating laryngeal hyperresponsiveness and triggering episodes, necessitating integrated management of these factors for optimal recovery.^[3]^[33] Chronic misdiagnosis, often as refractory asthma, leads to complications including unnecessary long-term corticosteroid use, which can result in morbidity such as Cushing-like syndrome, bone density loss, and reduced quality of life.^[26] In severe cases of misdiagnosis, up to 28% of patients may require intubation due to acute respiratory distress.^[3] Regular follow-up with multidisciplinary monitoring, including patient education on breathing techniques and trigger avoidance, is essential to sustain improvements and prevent relapse.^[25]

Epidemiology

Vocal cord dysfunction (VCD), also known as inducible laryngeal obstruction, has an unknown overall prevalence in the general population due to the absence of large-scale prospective cohort studies and variability in diagnostic criteria.^[48] It is frequently underdiagnosed, often presenting as an incidental finding during evaluations in ear, nose, and throat (ENT) clinics or as a mimic of refractory asthma.^[26] Among patients with asthma, particularly those with severe or unresponsive cases, VCD coexists in approximately 25% of adults and up to 14% of children and adolescents requiring hospitalization.^[25]^[16] In referral centers for difficult-to-treat asthma, prevalence can reach up to 10%.^[26] True rates may be higher in high-risk groups, such as those with frequent emergency department visits for dyspnea, where estimates range from 2.5% to 22%.^[16] Demographically, VCD predominantly affects females, with a female-to-male ratio of approximately 3:1.^[16]^[26] It occurs across all ages, from infants to individuals in their 80s, but is most commonly diagnosed in adolescents and young adults aged 20 to 40 years, with about 35% of cases involving children (median age 14 years).^[16]^[26] Incidence is notably elevated in certain subgroups, including elite athletes, where exercise-induced laryngeal obstruction—a related form of VCD—affects 5% to 8% of adolescents and young adults.^[49] For instance, it is more prevalent among female athletes and those in high-achievement environments, such as competitive swimmers or military recruits.^[16] Geographically, no strong regional variations have been identified, with cases reported consistently across studies in North America, Europe, and other areas, suggesting a global distribution uninfluenced by locale.^[16] Awareness of VCD has risen since the early 2000s, driven by improved laryngoscopic diagnostics and recognition of its overlap with asthma, leading to more frequent identification in clinical settings.^[26] However, studying VCD epidemiology faces significant challenges, including limited large-scale research, inconsistent definitions, and reliance on retrospective or selected cohorts, which hinder accurate incidence tracking and population-level estimates.^[16]^[48]

References

[1]
Vocal cord dysfunction: Is it a type of asthma? - Mayo Clinic
Vocal cord dysfunction is the abnormal closing of the vocal cords when you breathe in or out. It's also called laryngeal dysfunction, paradoxical vocal cord ...
[2]
Vocal Cord Dysfunction (Inducible Laryngeal Obstruction)
If you have vocal cord dysfunction (VCD), your vocal cords don't open all the way when you breathe in. Healthcare providers can treat VCD.
[3]
Vocal cord dysfunction: a review - PMC - NIH
Sep 22, 2015 · Vocal cord dysfunction (VCD) is a term that refers to inappropriate adduction of the vocal cords during inhalation and sometimes exhalation.Missing: definition | Show results with:definition
[4]
Vocal Cord Dysfunction Symptoms, Diagnosis, Treatment ...
Vocal cord dysfunction (VCD) or paradoxical vocal fold movement (PVFM) occurs when the vocal cords (voice box) do not open correctly.Missing: definition | Show results with:definition
[5]
Recognizing Vocal Cord Dysfunction: Exercising Caution Before ...
Oct 5, 2023 · Vocal cord dysfunction typically presents with symptoms such as wheezing, stridor, tachypnea, dysphonia, or cough and may be misdiagnosed as ...
[6]
Inducible laryngeal obstruction: an official joint European ...
Inducible laryngeal obstruction (ILO) describes an inappropriate, transient, reversible narrowing of the larynx in response to external triggers.Introduction · Diagnostic approach · Epidemiology · Comorbidities
[7]
Vocal Cord Dysfunction | Johns Hopkins Medicine
Vocal cord dysfunction or paradoxical vocal fold motion (PVFM) is an episodic condition that results when vocal cord movement is dysfunctional.
[8]
Vocal Cord Dysfunction - Pulmonary Disorders - Merck Manuals
Vocal cord dysfunction involves paradoxical or dysfunctional movement of the vocal cords and ... Vocal cord paralysis (unilateral and bilateral) is ...
[9]
Vocal cord paralysis - Symptoms and causes - Mayo Clinic
Vocal cord paralysis is a condition that causes the loss of control of the muscles that control the voice. It happens when the nerve impulses to the voice ...
[10]
Paradoxical vocal cord motion disorder: past, present and future - PMC
Paradoxical vocal cord motion disorder (PVCM), also called vocal cord dysfunction, is an important differential diagnosis for asthma.
[11]
Full article: Differentiating vocal cord dysfunction from asthma
Oct 12, 2017 · More than a century later, in 1974, Patterson et al used the term “Munchausen's stridor” to describe nonorganic laryngeal obstruction in a ...Introduction · Pulmonary Function Tests · SpirometryMissing: naming | Show results with:naming
[12]
Anatomy, Head and Neck, Larynx Vocal Cords - StatPearls - NCBI
The vocal fold comprises five layers (deep to superficial layers as follows): thyroarytenoid muscle, deep lamina propria, intermediate lamina propria, ...
[13]
Mechanics of human voice production and control - PMC
The vocal folds are located in the larynx and form a constriction to the airway [Fig. 1(a)]. Each vocal fold is about 11–15 mm long in adult women and 17–21 mm ...
[14]
How Does the Human Body Produce Voice and Speech? - NIDCD
Mar 13, 2023 · Voice is generated by airflow from the lungs. When the air from the lungs blows through the vocal folds at a high speed, the vocal folds vibrate.
[15]
Vocal Cord and Voice Box Anatomy - Medscape Reference
Mar 27, 2025 · The vocal folds, also known as vocal cords, are located within the larynx (also colloquially known as the voice box) at the top of the trachea.
[16]
https://erj.ersjournals.com/content/37/1/194
[17]
Characterization of 68 Consecutive Pediatric Vocal Cord ... - PubMed
... Vocal Cord Dysfunction specialty clinic from February 2018 to February 2020. ... Median time from initial symptoms to presentation was 12 months ( ...
[18]
Vocal Cord Disorder Often Mistaken for Asthma in Elite Athletes
Apr 12, 2013 · An estimated five percent of athletes have PVFMD, which can severely impact performance. ... dysfunction,” said Anna Marcinow, MD, co-author of ...Missing: performers | Show results with:performers
[19]
Vocal cord dysfunction masquerading as exercise-induced asthma ...
The present report describes seven elite athletes with psychogenic vocal cord dysfunction who presented with acute dyspnea during sporting competitions.Missing: performers | Show results with:performers<|control11|><|separator|>
[20]
A CASE OF SEVERE VOCAL CORD DYSFUNCTION ...
Some studies have reported laryngopharyngeal reflux (LPR) to be linked to VCD (2-3). Here we present a case of VCD aggravated by uncontrolled LPR with recurrent ...
[21]
Vocal cord dysfunction: what do we know? - ERS Publications
VCD related dyspnoea is characterised by sudden onset, short duration (mostly <2 min) and is typically self-limited. Classically inspiration is affected and the ...<|separator|>
[22]
You ARE a Vocal Athlete | Medical School
Vocal Cord Dysfunction (VCD)/Functional Breathing Disorders · Treatments ... Again, they are aimed at singers but apply to all vocal athletes. MUSCLE ...Missing: performers | Show results with:performers
[23]
Segmental Laryngeal Dystonia: A Difficult Differential of Vocal Cord ...
Segmental Laryngeal Dystonia: A Difficult Differential of Vocal Cord Dysfunction Presenting During Immunotherapy. R.P. Harvey. R.P. Harvey. Affiliations.
[24]
Vocal Cord Dysfunction: Rapid Evidence Review - AAFP
A suggested approach to the diagnosis of vocal cord dysfunction includes obtaining a clinical history focusing on triggers (Table 3) and symptoms, physical ...
[25]
Vocal Cord Dysfunction - Medscape Reference
Jun 24, 2024 · Signs and symptoms · Wheezing · Cough · A feeling of tightness in the throat · Hoarseness and voice change · Stridor · Shortness of breath · Dyspnea on ...Missing: cyanosis | Show results with:cyanosis
[26]
https://emedicine.medscape.com/article/137782-overview
[27]
For athletes, difficulty breathing may be caused by vocal cord disorder
Mar 19, 2017 · PVFM is also called vocal cord dysfunction and is a disorder of the upper airway where the vocal folds (vocal cords) and surrounding muscles ...Missing: performers | Show results with:performers
[28]
Vocal cord dysfunction in former World Trade Center (WTC) rescue ...
Jan 22, 2008 · It has been associated with exposures to irritants, as well as with psychological illnesses and conditions.
[29]
The Impact of Vocal and Laryngeal Pathologies Among Professional ...
Professional singers are at an increased risk of laryngeal pathologies and symptoms associated with vocal misuse and overuse, particularly hoarseness, GERD, ...
[30]
Vocal Cord Dysfunction - AAFP
Jan 15, 2010 · Vocal cord dysfunction involves inappropriate vocal cord motion that produces partial airway obstruction. Patients may present with ...Abstract · Differential Diagnoses · Precipitating Factors · Diagnostic Approaches
[31]
Vocal Cord Dysfunction - EMCrit Project
Jun 22, 2020 · Vocal Cord Dysfunction (VCD) is known by a variety of names, including: Paradoxical vocal fold motion. Inducible laryngeal obstruction.
[32]
Laryngeal Dysfunction: Assessment and Management for the Clinician
Jun 22, 2016 · This review provides an overview of the current state of knowledge in the field of laryngeal dysfunction, with a focus on pragmatic clinical assessment and ...Laryngeal Development: Di. · The Concept of Clinical L. · Approach to Assessment
[33]
Vocal Cord Dysfunction Differential Diagnoses - Medscape Reference
Jun 24, 2024 · Laryngomalacia, vocal cord paresis, and CNS causes must be differentiated from vocal cord dysfunction (VCD).
[34]
Vocal Cord Dysfunction Treatment & Management
Jun 24, 2024 · Speech therapy. The mainstays of treatment for vocal cord dysfunction (VCD) involve teaching the patient vocal cord relaxation techniques and ...Approach Considerations · Medical Care
[35]
A Systematic Review of Psychological Interventions for Adult and ...
Treatment of patients with VCD involves a multidisciplinary approach that involves use of breathing techniques to help relax the vocal cords, reduce muscle ...
[36]
Novel Therapy Helps Athletes Overcome Vocal Cord Dysfunction
Oct 31, 2016 · A new study shows that a novel, nonsurgical approach to treating vocal cord dysfunction (VCD) can help 3 out of 4 adolescent athletes, who did not respond to ...Missing: performers | Show results with:performers
[37]
Systematic review of the effectiveness of non-pharmacological ...
Jun 15, 2022 · Treatment effectiveness for vocal cord dysfunction ... Change in exercise capacity after speech therapy in patients with vocal cord dysfunction.
[38]
One Hundred Case Series of Vocal Cord Dysfunction in a Military ...
One Hundred Case Series of Vocal Cord Dysfunction in a Military Treatment Facility · Clifford Nolt, MD · Michael Ott, MD · Ryann Ennis, MA, CCC-SLP · Jose Roman, MD.
[39]
Successful Treatment of Paradoxical Vocal Cord Motion with Sub ...
... treatment of PVCM using sub-dissociative dose ketamine. This ... Morris MJ, Allan PF, Perkins PJ. Vocal cord dysfunction: etiologies and treatment.
[40]
Vocal fold botulinum toxin injection for refractory ... - PubMed
Dec 13, 2018 · Conclusion: Vocal fold botulinum toxin injection is a safe and effective treatment ... Vocal Cord Dysfunction / drug therapy*; Vocal Cords / drug ...
[41]
https://pmc.ncbi.nlm.nih.gov/articles/PMC6370423/
[42]
Multidisciplinary approach to vocal cord dysfunction diagnosis and ...
Patients were evaluated with a multidisciplinary team approach, including speech therapy assessment, otolaryngology exam and flexible laryngoscopy. Patients ...
[43]
Functional Outcomes after Behavioral Treatment of Paradoxical ...
Jan 26, 2018 · More than two thirds of the respondents reported a reduction in PVFM-related anxiety (68%) and feelings of helplessness (69%) after treatment.
[44]
Long-term outcome of vocal cord dysfunction - ScienceDirect
Following an in-depth review of the medical literature, this article examines the available retrospective and prospective evidence to present an approach ...
[45]
Vocal Cord Dysfunction: A Frequently Forgotten Entity - PMC
Vocal cord dysfunction (VCD) is a disorder characterized by unintentional paradoxical adduction of the vocal cords, resulting in episodic shortness of breath, ...
[46]
Exercise-induced laryngeal obstruction - UpToDate
### Summary of Prevalence Estimates and Demographics for EILO