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Hyperventilation

Hyperventilation is a physiological state characterized by rapid or deep breathing that exceeds the body's metabolic requirements, resulting in excessive elimination of carbon dioxide (CO₂) from the bloodstream and leading to hypocapnia, or low CO₂ levels.^[1]^[2] This imbalance disrupts the acid-base equilibrium, causing respiratory alkalosis with elevated blood pH, which can manifest as a range of acute symptoms due to changes in cerebral blood flow, ionized calcium levels, and neuromuscular excitability.^[3] While often transient and self-limiting, chronic or recurrent episodes may indicate hyperventilation syndrome, a functional disorder frequently linked to psychological factors.^[4] The condition arises from either organic or psychogenic causes, with the latter being more prevalent in non-emergency settings. Organic triggers include medical emergencies such as severe pain, bleeding, infections, heart or lung diseases, and drug effects, which stimulate the respiratory centers in the brainstem to increase ventilation.^[1] Psychogenic factors, such as anxiety, panic attacks, stress, or emotional distress, account for many cases, where heightened sympathetic nervous system activity prompts overbreathing as a somatic expression of underlying psychological tension.^[3] In rare instances, it can stem from central nervous system disorders or high-altitude exposure, though these are distinct from the behavioral hyperventilation syndrome.^[5] Common symptoms include dizziness, lightheadedness, shortness of breath, chest pain or tightness, rapid heartbeat, paresthesia (tingling in extremities), muscle spasms or tetany, dry mouth, belching, and blurred vision, often exacerbated by the alkalotic state affecting nerve and muscle function.^[1] These can mimic serious cardiac or pulmonary events, prompting urgent evaluation. Diagnosis typically involves clinical history, observation of breathing patterns, and exclusion of organic pathology through arterial blood gas analysis showing low PaCO₂ (partial pressure of CO₂) and elevated pH, alongside normal oxygenation.^[6] Treatment focuses on addressing the root cause: rebreathing techniques like pursed-lip breathing to restore CO₂ levels, relaxation exercises, cognitive-behavioral therapy for anxiety-related cases, and medical intervention for underlying conditions.^[1] Prompt care is essential if accompanied by severe pain, fever, or neurological changes to rule out life-threatening etiologies.^[1]

Definition and Pathophysiology

Definition

Hyperventilation is defined as breathing that is rapid or deep enough to exceed the body's metabolic requirements, leading to excessive elimination of carbon dioxide and resulting in hypocapnia, or low levels of carbon dioxide in the blood.^[1]^[2] This overbreathing disrupts the normal balance of gases in the body, often causing a range of physiological effects.^[7] A key distinction exists between acute hyperventilation, which involves sudden, episodic bouts of rapid breathing typically triggered by immediate stressors, and hyperventilation syndrome, a recurrent condition often linked to psychogenic factors where patients experience persistent overbreathing without an underlying organic cause. However, the concept of hyperventilation syndrome has faced criticism, with some researchers questioning its scientific validity as a separate disorder.^[8]^[9] Hyperventilation syndrome is characterized by chronic symptoms stemming from repeated episodes, whereas acute hyperventilation resolves more quickly once the precipitant is addressed.^[8] The term hyperventilation emerged in early 20th-century medical literature to describe breathing beyond physiological needs, with "hyperventilation syndrome" specifically coined in 1938 by Kerr et al. to refer to anxiety-associated overbreathing leading to tetany and other symptoms.^[7] Clinically, hyperventilation in adults is often indicated by a respiratory rate exceeding 20 breaths per minute at rest or an increase in tidal volume that reduces arterial partial pressure of carbon dioxide (PaCO₂) below 35 mmHg, the lower threshold of normal (35-45 mmHg).^[10]^[11] This hypocapnia can briefly induce respiratory alkalosis, a condition of elevated blood pH due to reduced carbon dioxide levels.^[2]

Pathophysiology

Hyperventilation involves an increase in alveolar ventilation that exceeds metabolic demands, leading to excessive expulsion of carbon dioxide and a reduction in arterial partial pressure of CO₂ (PaCO₂) below the normal range of 35–45 mmHg. This hypocapnia directly causes respiratory alkalosis, characterized by an elevation in blood pH above 7.45, as the loss of CO₂ shifts the carbonic acid-bicarbonate equilibrium toward alkalinity. The relationship is governed by the Henderson-Hasselbalch equation:

\text{pH} = 6.1 + \log_{10} \left( \frac{[\text{HCO}_3^-]}{0.03 \times \text{PaCO}_2} \right)

In this equation, the initial stability of bicarbonate concentration ([HCO₃⁻]) relative to the falling PaCO₂ results in a logarithmic rise in pH, amplifying the alkalotic state during acute episodes.^[12]^[13]^[14] The resulting hypocapnia triggers distinct vascular responses: in the cerebral circulation, low PaCO₂ induces vasoconstriction of cerebral arterioles, which decreases cerebral blood flow by approximately 2–4% per mmHg drop in PaCO₂, potentially compromising oxygen delivery to brain tissue. Conversely, in the peripheral vasculature, hypocapnia promotes vasodilation, increasing blood flow to extremities such as the forearms while contributing to a net reduction in systemic vascular resistance. These hemodynamic changes underscore the localized sensitivity of vascular tone to CO₂ levels.^[15]^[16]^[17] At the ionic level, respiratory alkalosis alters calcium homeostasis through pH-dependent protein binding. The elevated pH reduces hydrogen ion concentration, increasing the negative charge on albumin and other proteins, which enhances their affinity for calcium ions and decreases serum ionized calcium (Ca²⁺) levels despite total calcium remaining unchanged. This hypocalcemia disrupts neuromuscular excitability, predisposing to phenomena such as tetany and paresthesia via heightened nerve and muscle irritability. Over time, the body mounts a renal compensatory response, where the kidneys reduce bicarbonate reabsorption in the proximal tubules and increase its urinary excretion, typically beginning within 2–6 hours and achieving partial pH normalization over 1–3 days, thereby mitigating the alkalosis.^[12]^[18]^[19]^[20]

Causes

Psychological Causes

Hyperventilation is primarily triggered by psychological factors such as anxiety and panic disorders, in which an acute fear response activates the sympathetic nervous system, leading to heightened respiratory drive and overbreathing.^[21]^[22] This activation occurs as part of the body's fight-or-flight mechanism, where emotional distress prompts rapid, deep breathing to compensate for perceived threats, often without an underlying physiological need.^[23] In these scenarios, the resulting hypocapnia from excessive exhalation of carbon dioxide can exacerbate symptoms, creating a cycle that intensifies the initial anxiety.^[24] Specific psychological conditions associated with hyperventilation include panic disorder, as defined by DSM-5 criteria involving recurrent unexpected panic attacks followed by at least one month of persistent concern or behavioral changes, and generalized anxiety disorder characterized by excessive worry and physical tension.^[25] Hyperventilation syndrome, a chronic form linked to these disorders, manifests with estimates suggesting a prevalence of up to 10% among primary care patients, with anxiety serving as a core precipitant in most cases.^[26] Behavioral aspects further contribute, as hyperventilation can become a learned response to stress, perpetuated through a self-reinforcing feedback loop where physical symptoms like dizziness or chest tightness heighten fear and drive further overbreathing.^[27] This pattern is particularly evident in individuals with repeated exposure to stressors, reinforcing the habit through classical conditioning.^[28] The condition was recognized in the mid-20th century, notably in the 1950s, as "hyperventilation syndrome" within the framework of psychosomatic medicine, highlighting its roots in emotional and psychological origins rather than purely organic causes.^[29] Risk factors include high-stress environments and a history of trauma, which amplify vulnerability to these episodes.^[30] It is more prevalent among females aged 15-55, with gender ratios ranging from 2:1 to 7:1 compared to males, possibly influenced by hormonal factors and societal stress patterns.^[26]

Physiological Causes

Physiological causes of hyperventilation involve medical conditions and environmental factors that elevate the body's ventilatory demand or stimulate respiratory centers, often through hypoxemia, pain, increased metabolic rate, or direct chemoreceptor activation. These etiologies differ from psychological triggers by stemming from organic dysfunctions or external stimuli rather than emotional distress.^[31] Respiratory disorders frequently induce hyperventilation by impairing gas exchange and increasing the work of breathing. Asthma exacerbations cause airway obstruction and hypoxemia, prompting compensatory hyperventilation to maintain oxygenation.^[32] Similarly, pneumonia leads to alveolar inflammation and reduced oxygen diffusion, stimulating ventilatory drive via peripheral chemoreceptors.^[1] Pulmonary embolism obstructs pulmonary vasculature, resulting in acute hypoxemia and ventilation-perfusion mismatch that drives hyperventilation.^[33] Cardiovascular conditions contribute by causing pulmonary congestion, pain, or irregular rhythms that activate chemoreceptors or heighten sympathetic tone. Heart failure induces fluid accumulation in the lungs, leading to dyspnea and reflex hyperventilation.^[1] Arrhythmias, such as atrial fibrillation, can reduce cardiac output and cause hypoxemia, triggering increased respiratory rate.^[34] Pain from myocardial infarction stimulates both central and peripheral mechanisms, promoting hyperventilation as a response to tissue ischemia.^[35] Metabolic disturbances often necessitate compensatory hyperventilation to correct acid-base imbalances or meet heightened demands. In pregnancy, elevated progesterone levels directly stimulate the medullary respiratory center, causing chronic mild hyperventilation to support fetal oxygenation needs.^[31] Salicylate overdose, as in aspirin toxicity, directly excites the respiratory centers in the medulla, resulting in primary respiratory alkalosis.^[36] Hepatic failure promotes hyperventilation through elevated levels of progesterone and estradiol, which stimulate the respiratory centers, often resulting in primary respiratory alkalosis.^[37] Other physiological factors include fever and sepsis, which raise metabolic rate and cytokine-mediated stimulation of ventilation. High altitude exposure activates peripheral chemoreceptors due to low oxygen partial pressure, eliciting hypoxic hyperventilation. Mismatches in mechanical ventilation, such as excessive tidal volume or rate settings, can iatrogenically induce hyperventilation in critically ill patients. These mechanisms result in respiratory alkalosis, as explored in the Pathophysiology section.^[31]^[38]^[39]

Signs and Symptoms

Acute Symptoms

Acute hyperventilation episodes manifest with a range of immediate physical and sensory disturbances primarily resulting from respiratory alkalosis and hypocapnia-induced cerebral vasoconstriction. Common symptoms include dizziness and lightheadedness due to reduced cerebral blood flow, as well as shortness of breath and a sensation of chest tightness or pain, which can intensify the distress.^[1]^[21]^[24] Neuromuscular effects are prominent, with carpopedal spasms—characterized by involuntary contractions of the hands and feet—arising from tetany caused by lowered ionized calcium levels. Sensory disturbances often involve paresthesia, presenting as tingling or numbness in the extremities, perioral region, or fingertips, alongside occasional visual blurring from transient cerebral hypoperfusion.^[1]^[21]^[40] Autonomic responses during these episodes typically feature tachycardia, with a rapid and pounding heartbeat, diaphoresis (profuse sweating), and pallor, reflecting sympathetic activation. In psychogenic cases, patients frequently report an overwhelming feeling of impending doom, exacerbating the episode. These symptoms often mimic acute cardiac events like heart attacks or neurological emergencies such as strokes, prompting frequent emergency department visits for evaluation.^[41]^[24]^[42] Untreated episodes generally last 20 to 30 minutes, resolving as carbon dioxide levels normalize and breathing stabilizes, though they may extend up to an hour in some instances.^[43]^[41]

Chronic Manifestations

Chronic hyperventilation syndrome is characterized by recurrent episodes of excessive breathing that persist over time, often leading to sustained respiratory alkalosis and a range of ongoing symptoms. These episodes frequently manifest as persistent fatigue and insomnia, which can significantly disrupt daily routines and contribute to overall exhaustion. Gastrointestinal upset, such as bloating, belching, and epigastric discomfort resembling irritable bowel syndrome-like symptoms, arises from aerophagia and the effects of chronic hypocapnia on gut motility.^[44]^[46] The psychological toll of chronic hyperventilation is profound, with increased anxiety sensitivity to respiratory sensations exacerbating fear responses and leading to heightened emotional distress. This can foster avoidance behaviors, where individuals steer clear of situations perceived as triggering, potentially progressing to agoraphobia in those with comorbid panic disorder. Hyperventilation syndrome is frequently associated with panic disorder.^[47]^[48]^[41] Physically, repeated episodes result in adaptations such as muscle weakness due to recurrent spasms and tetany from ionized calcium imbalances induced by alkalosis. Chronic headaches emerge from cerebral vascular changes, including vasoconstriction caused by sustained low carbon dioxide levels, which reduce cerebral blood flow and provoke persistent discomfort.^[46]^[26]^[49] The prevalence of chronic hyperventilation syndrome affects 6 to 11% of the general population, with a notable predominance in females during the third and fourth decades of life. This condition substantially impairs quality of life, reducing daily functioning through cumulative fatigue and anxiety while increasing healthcare utilization due to frequent medical consultations for unexplained symptoms.^[50]^[51]^[52]

Diagnosis

Clinical Evaluation

Clinical evaluation of hyperventilation begins with a detailed history to determine the onset, duration, and potential triggers of symptoms, distinguishing between acute episodes often linked to anxiety or stress and those precipitated by physiological factors such as pain or exertion.^[44] Patients typically report sudden dyspnea, chest tightness, paresthesias, dizziness, or perioral numbness, with associated symptoms like palpitations or a sense of impending doom in psychogenic cases.^[46] To screen for hyperventilation syndrome, the Nijmegen Questionnaire—a validated 16-item tool assessing symptoms such as chest pain, shortness of breath, and anxiety on a 0-4 scale—can be administered, where a score exceeding 23 out of 64 indicates likely dysfunctional breathing patterns.^[53] The physical examination focuses on observing the breathing pattern, which in acute hyperventilation often presents as rapid, shallow respirations contrasting with the deep, labored Kussmaul breathing seen in metabolic acidosis mimics. Vital signs may reveal tachypnea (respiratory rate >20 breaths per minute), tachycardia, and normal or near-normal oxygen saturation on pulse oximetry.^[44] Neurological assessment includes checks for tetany, such as carpopedal spasms, positive Chvostek or Trousseau signs due to ionized hypocalcemia from respiratory alkalosis, and signs of perioral or acral tingling.^[46] Additional findings might include diaphoresis, tremor, or chest wall tenderness without focal deficits.^[44] Differential diagnosis involves targeted questioning to exclude organic mimics, such as inquiring about polyuria and polydipsia for diabetic ketoacidosis or recent immobilization for pulmonary embolism, while ruling out cardiac ischemia through details on exertional onset.^[44] Red flags prompting urgent investigation include radiating chest pain suggestive of myocardial infarction or altered mental status indicating possible central nervous system pathology or severe metabolic derangement.^[46] The provider's approach emphasizes a calm, reassuring demeanor to interrupt the cycle of anxiety-driven hyperventilation, with current clinical recommendations advocating non-invasive bedside assessment as the initial step before considering further testing.^[46]

Diagnostic Tests

The arterial blood gas (ABG) analysis is considered the gold standard diagnostic test for confirming hyperventilation, as it directly measures blood pH, partial pressure of carbon dioxide (PaCO₂), and partial pressure of oxygen (PaO₂). In acute hyperventilation, ABG typically reveals respiratory alkalosis with PaCO₂ below 35 mmHg, pH above 7.45, and normal PaO₂ levels around 80-100 mmHg, distinguishing it from other acid-base disturbances.^[46]^[54] This test is particularly valuable during symptomatic episodes, though normal results may occur between attacks in chronic cases, necessitating correlation with clinical presentation.^[54] Capnography offers a non-invasive, real-time alternative for assessing ventilation status through end-tidal CO₂ (EtCO₂) monitoring, which reflects alveolar CO₂ levels. During a hyperventilation episode, EtCO₂ values below 30 mmHg confirm excessive CO₂ elimination, aiding in immediate diagnosis and excluding conditions like hypoventilation.^[54] This tool is especially useful in emergency settings or during provocative testing, providing waveform analysis to detect irregular breathing patterns.^[55] Additional laboratory evaluations support diagnosis by ruling out underlying causes and associated imbalances. Serum electrolytes often show decreased ionized calcium due to alkalosis-induced binding of calcium to albumin, contributing to symptoms like paresthesia.^[54] A complete blood count (CBC) helps exclude anemia as a trigger for compensatory hyperventilation, while troponin levels assess for myocardial injury in cases mimicking cardiac events.^[54] Imaging and cardiac tests are selectively employed to investigate potential organic etiologies. A chest X-ray or computed tomography (CT) scan is indicated if structural respiratory pathology, such as pneumonia or embolism, is suspected, though findings are typically normal in primary hyperventilation syndrome.^[56] An electrocardiogram (ECG) evaluates for arrhythmias or ischemia, as hyperventilation can induce transient ST-segment changes, T-wave inversions, or QT prolongation.^[56]^[54] The provocative test, involving supervised voluntary hyperventilation for 3-4 minutes, reproduces symptoms and hypocapnia to affirm the diagnosis, but it must be used cautiously to avoid inducing anxiety or complications in susceptible patients.^[8] This approach, per current clinical practice, is reserved for ambiguous cases after initial evaluations.^[8]

Management and Treatment

Acute Interventions

The primary goal of acute interventions for hyperventilation is to restore normal respiratory patterns, alleviate symptoms, and prevent complications during an ongoing episode, typically triggered by anxiety or other stressors.^[57] Immediate management focuses on non-invasive techniques to increase carbon dioxide retention and reduce respiratory rate, while ruling out underlying organic causes.^[46] Breathing techniques form the cornerstone of acute care, emphasizing controlled, slow respiration to counteract excessive ventilation. Diaphragmatic breathing, which engages the diaphragm rather than the chest wall, slows the respiratory rate, reduces dyspnea, and promotes CO2 retention, often resolving symptoms in a high proportion of cases.^[57] Pursed-lip breathing, where exhalation occurs through pursed lips as if whistling, further limits airflow and helps normalize pH levels by facilitating gradual CO2 reaccumulation.^[5] These methods are preferred over outdated practices like rebreathing into a paper bag, which can induce hypoxia and has been linked to fatalities in patients with undiagnosed conditions such as myocardial infarction or pneumothorax.^[57] In severe cases driven by acute anxiety, pharmacologic intervention with benzodiazepines may be warranted to interrupt the cycle of panic and hyperventilation. Low-dose lorazepam (0.5-2 mg intravenously or intramuscularly) can provide rapid anxiolysis and symptom relief without significantly depressing respiration in non-comorbid patients.^[58] Supplemental oxygen is reserved for instances of confirmed hypoxia, as arterial oxygen saturation typically remains near 100% in uncomplicated hyperventilation syndrome; routine administration is avoided to prevent potential CO2 retention issues.^[41] Environmental modifications play a crucial role in de-escalation, including placement in a quiet, calm setting with verbal reassurance to affirm safety and the transient nature of the episode.^[46] Positioning the patient comfortably, such as sitting upright or in a relaxed posture, further minimizes panic and facilitates breathing retraining.^[5] Throughout intervention, continuous monitoring of vital signs, including pulse oximetry to track oxygen saturation and end-tidal CO2 if available, ensures stability and detects any deviations.^[54] Systematic reviews indicate limited high-quality evidence for the effectiveness of breathing retraining in hyperventilation syndrome.^[59]

Long-term Strategies

Long-term management of recurrent hyperventilation focuses on addressing underlying psychological and physiological factors through structured interventions that promote sustained respiratory control and anxiety reduction. These strategies aim to prevent episodes by targeting triggers such as stress and maladaptive breathing patterns, emphasizing multidisciplinary approaches involving psychotherapy, pharmacological support, and behavioral modifications.^[57] Cognitive behavioral therapy (CBT) is a cornerstone for treating hyperventilation linked to anxiety disorders, as it helps patients identify and modify thought patterns and behaviors that exacerbate rapid breathing. By focusing on exposure techniques and cognitive restructuring, CBT reduces the frequency and severity of episodes; meta-analyses of CBT for panic and anxiety disorders, which often include hyperventilation symptoms, indicate strong efficacy.^[60]^[61] Breathing retraining programs teach diaphragmatic and paced respiration to normalize ventilation and counteract habitual overbreathing, often incorporating biofeedback devices that monitor end-tidal CO2 levels for real-time guidance. These techniques, delivered through sessions or mobile apps like Paced Breathing, enable patients to practice controlled inhales and exhales, fostering awareness of triggers and avoidance strategies to prevent recurrence. Education on recognizing early signs, such as sighing or mouth breathing, further empowers self-management. Systematic reviews indicate limited high-quality evidence for the effectiveness of breathing exercises in hyperventilation syndrome.^[57]^[62]^[63]^[59] Pharmacotherapy targets comorbid conditions like anxiety or asthma that perpetuate hyperventilation, with selective serotonin reuptake inhibitors (SSRIs) such as sertraline commonly prescribed to diminish episode intensity by modulating serotonin levels and stabilizing mood. For patients with respiratory comorbidities, bronchodilators or anti-inflammatory agents may be integrated to address overlapping symptoms, always under specialist oversight to avoid exacerbating alkalosis.^[64]^[57] Lifestyle modifications play a vital role in prevention, including regular stress management practices like yoga and mindfulness meditation, which enhance parasympathetic activity and promote relaxed breathing patterns. Incorporating aerobic exercise, such as walking or swimming, three to five times weekly improves overall respiratory efficiency and resilience to triggers, while ongoing follow-up with a pulmonologist or psychiatrist ensures tailored adjustments and monitors progress.^[21]^[65]^[66] The prognosis for hyperventilation syndrome is favorable with consistent intervention, leading to significant symptom reduction in most cases, though untreated chronic forms can persist with recurrent exacerbations in approximately 50% of affected individuals, particularly those with underlying panic disorder.^[8]^[67]

Complications

Short-term Risks

Hyperventilation can lead to syncope through cerebral hypoperfusion caused by hypocapnia-induced vasoconstriction, resulting in reduced blood flow to the brain.^[68] This transient loss of consciousness poses risks of falls and injuries, with studies indicating that over 50% of syncope cases involve falls and approximately 44% result in injury.^[69] The respiratory alkalosis from hyperventilation may trigger cardiac arrhythmias, including QT interval prolongation and ventricular ectopy, due to shifts in electrolytes such as hypokalemia.^[70] These rhythm disturbances arise from the alkalotic environment altering myocardial repolarization, potentially leading to more serious ventricular arrhythmias in susceptible individuals.^[71] In severe episodes, hyperventilation may cause altered consciousness or even apnea, increasing the risk of aspiration if vomiting occurs during impaired awareness.^[72] This complication is particularly concerning in acute settings where protective airway reflexes are compromised.^[73] Symptoms of hyperventilation often overlap with those of acute cardiac events, leading to misdiagnosis of true emergencies like myocardial infarction as anxiety-related hyperventilation, which can delay critical interventions and worsen outcomes.^[74] Such diagnostic errors are more common in presentations involving chest pain and dyspnea, contributing to adverse events in emergency care.^[75]

Long-term Consequences

Repeated episodes of hyperventilation can escalate underlying anxiety, contributing to the development or worsening of chronic anxiety disorders, including full-blown panic disorder and comorbid depression. Approximately 50% of individuals with panic disorder experience hyperventilation as a prominent symptom, and untreated hyperventilation syndrome (HVS) perpetuates a cycle of fear and avoidance that heightens the risk of these mental health conditions. Longitudinal studies indicate that patients with chronic respiratory symptoms, such as those in HVS, face 2- to 3-fold higher odds of anxiety treatment compared to the general population, underscoring the need for early intervention to mitigate psychiatric comorbidity.^[8]^[76]^[77] On the respiratory front, chronic hyperventilation leads to fatigue in the intercostal and accessory respiratory muscles due to persistent overuse, resulting in chest wall tenderness and pain that may resemble costochondritis. This pattern of upper thoracic breathing, rather than diaphragmatic, can reduce ventilatory efficiency over time. In some cases, these symptoms can persist for years, severely impacting health-related quality of life.^[78]^[44]^[79]^[51] Neurologically, recurrent hypocapnia from hyperventilation induces cerebral vasoconstriction, which can manifest as persistent headaches and cognitive fog due to reduced cerebral blood flow. This vasoconstrictive effect disrupts normal brain perfusion, leading to symptoms like dizziness, concentration difficulties, and mental fatigue that linger beyond acute episodes. Such effects are particularly pronounced in chronic HVS, where ongoing alkalosis exacerbates neurological complaints.^[79]^[80]^[15] Cardiovascular strain from repeated hyperventilation activates the chronic stress response, elevating heart rate and sympathetic activity, which increases the risk of hypertension. Case reports and physiological studies link HVS to coronary vasospasm and higher resting heart rates, markers associated with long-term cardiovascular disease progression. Untreated, this can compound with mental health comorbidities, further elevating hypertension odds by up to 3-fold in related anxiety conditions.^[81]^[82]^[83]

References

[1]
Hyperventilation: MedlinePlus Medical Encyclopedia
Jul 23, 2024 · Hyperventilation is rapid and deep breathing. It is also called overbreathing, and it may leave you feeling breathless.
[2]
The pathophysiology of hyperventilation syndrome - PubMed
Hyperventilation is defined as breathing in excess of the metabolic needs of the body, eliminating more carbon dioxide than is produced.<|control11|><|separator|>
[3]
Hyperventilation syndromes in medicine and psychiatry: a review - NIH
Hyperventilation syndromes in medicine and psychiatry: a review. ... Freeman L. J., Nixon P. G. Chest pain and the hyperventilation syndrome--some aetiological ...<|control11|><|separator|>
[4]
Dysfunctional breathing: what do we know? - PMC - NIH
The most well-known form of DB is hyperventilation syndrome (HVS), which is defined as acute or chronic hyperventilation (increased minute volume) at rest or ...
[5]
Central sleep apnea - Symptoms and causes - Mayo Clinic
Jul 29, 2025 · The change in oxygen at a high altitude can cause fast breathing, known as hyperventilation, followed by taking in too little air. Treatment- ...
[6]
Dyspnoea, hyperventilation and functional cough: a guide to which ...
Hyperventilation is not synonymous with tachypnoea, as patients may have an increased respiratory rate but a low tidal volume, thus maintaining a normal PaCO2.
[7]
Hyperventilation: MedlinePlus Medical Encyclopedia
Jul 23, 2024 · Hyperventilation is rapid and deep breathing. It is also called overbreathing, and it may leave you feeling breathless.
[8]
Primary Hyperventilation in the Emergency Department: A First ... - NIH
Jun 25, 2015 · Primary hyperventilation is defined as a state of alveolar ventilation in excess of metabolic requirements, leading to decreased arterial partial pressure of ...
[9]
Hyperventilation Syndrome: Practice Essentials, Pathophysiology ...
Sep 27, 2024 · As typically defined, HVS is a condition in which minute ventilation exceeds metabolic demands, resulting in hemodynamic and chemical changes ...
[10]
Physiology, Respiratory Rate - StatPearls - NCBI Bookshelf
Sep 12, 2022 · The regular respiratory rate changes with age, with 12 to 20 respirations per minute for a resting adult. However, in the elderly population, an ...Introduction · Organ Systems Involved · Function · Clinical Significance
[11]
Hypocarbia - StatPearls - NCBI Bookshelf
Feb 19, 2023 · Hypocarbia, also known as hypocapnia, is a decrease in alveolar and blood carbon dioxide (CO2) levels below the normal reference range of 35 mmHg.Missing: threshold | Show results with:threshold
[12]
Respiratory Alkalosis: Background, Pathophysiology, Epidemiology
Feb 18, 2025 · Acute hyperventilation with hypocapnia causes a small, early reduction in serum bicarbonate levels resulting from cellular shift of bicarbonate.Background · Pathophysiology · Epidemiology · Prognosis
[13]
Respiratory Alkalosis - Endocrine and Metabolic Disorders
Pseudorespiratory alkalosis occurs when mechanical ventilation (often hyperventilation) eliminates larger-than-normal amounts of alveolar carbon dioxide (CO 2).
[14]
Respiratory Alkalosis • LITFL Medical Blog • CCC Acid-base
Sep 15, 2023 · hyperventilation (ie increased alveolar ventilation) is the mechanism responsible for the lowered arterial pCO2 in ALL cases of respiratory ...
[15]
Hyperventilation in neurological patients: from physiology to ...
Hyperventilation causes cerebral vasoconstriction, which reduces cerebral blood flow and volume to decrease the oxygen supply in both normal and injured areas.
[16]
Hyperventilation and Cerebral Blood Flow | Stroke
Hypocapnic-hyperventilation has a profound, but probably temporary, effect on CBF, producing approximately a 2% decline in CBF for each 1 torr decline in ...<|separator|>
[17]
The Effect of Hypocapnia on Arterial Blood Pressure
peripheral resistance is decreased, indicating a net vasodilatation. The forearm blood flow is mark- edly increased, and the vascular resistance of the ...
[18]
Free ionized calcium | eClinpath
pH: Acidosis can increase the proportion of free ionized calcium (by causing release from protein), whereas alkalosis can decrease it (increases protein binding) ...
[19]
Respiratory Acidosis and Respiratory Alkalosis: Core Curriculum 2023
Jun 21, 2023 · Alkalosis decreases tissue oxygen delivery through at least 2 mechanisms. First, increased pH leads to a leftward shift in the oxygen ...
[20]
Respiratory Alkalosis | Current Medical Diagnosis & Treatment 2024
In acute cases (hyperventilation), there is light-headedness, anxiety, perioral numbness, and paresthesias. Tetany occurs from a low ionized calcium, since ...
[21]
Hyperventilation | Johns Hopkins Medicine
Hyperventilation is rapid or deep breathing, usually caused by anxiety or panic. This overbreathing, as it is sometimes called, may actually leave you feeling ...
[22]
Lactate and hyperventilation substantially attenuate vagal tone in ...
Many aspects of panic attacks, eg, palpitations, tremor, sweating, and an emotional sense of "fear," have been theorized to arise from sympathetic nervous ...
[23]
Stress effects on the body - American Psychological Association
Nov 1, 2018 · The autonomic nervous system has a direct role in physical response to stress and is divided into the sympathetic nervous system (SNS), and the ...
[24]
Hyperventilation in Panic Disorder and Asthma: Empirical Evidence ...
Hyperventilation is caused by increased alveolar ventilation relative to metabolic carbon dioxide production. Consequently, alveolar carbon dioxide pressure ...
[25]
Panic Disorder - StatPearls - NCBI Bookshelf - NIH
Aug 6, 2023 · According to DSM 5 (Fifth Edition) criteria, at least one panic attack must be followed by one month or more of persistent concern over having ...Continuing Education Activity · Introduction · Evaluation · Treatment / Management
[26]
Hyperventilation syndrome - MedLink Neurology
In 1922, Goldman was the first to connect "forced ventilation" and tetany and postulated that the tetany was due to alkalosis (29). Kerr and colleagues ...
[27]
Hyperventilation and panic disorder - PubMed
Panic and hyperventilation provoked by inappropriate activation of this system are postulated to reinforce each other by a positive feedback loop. Treatments ...
[28]
Hyperventilation: *The* Anxiety Attack Symptom - Calm Clinic
Hyperventilation is caused by anxiety, but hyperventilation can also end up warranting its own diagnosis: “hyperventilation syndrome.”
[29]
Symptom patterns of the hyperventilation syndrome - PubMed
Symptom patterns of the hyperventilation syndrome. Am J Med. 1950 Jun;8(6):691-700. doi: 10.1016/0002-9343(50)90093-3.Missing: recognized | Show results with:recognized
[30]
Panic disorder | NHS inform
Sep 24, 2025 · It's thought that panic disorder is probably caused by a combination of physical and psychological factors like: traumatic life experiences ...Symptoms Of A Panic Disorder · Diagnosing Panic Disorder · Management Of Panic Disorder
[31]
Hyperventilation Syndrome - an overview | ScienceDirect Topics
The term hyperventilation syndrome, first proposed in the 1930s, came under attack in the 1990s, and it was recommended that it be abolished. ... Because most ...<|control11|><|separator|>
[32]
Alkalosis - StatPearls - NCBI Bookshelf
Oct 29, 2024 · Hypoxic stimulation leads to hyperventilation in an attempt to correct hypoxia at the expense of CO2 loss.[11] Physiological causes of ...Etiology · Pathophysiology · History and Physical · Evaluation
[33]
Hyperventilation | American Journal of Respiratory and Critical Care ...
Asthma, especially when mild and atypical, is a potent cause of hyperventilation (6). We previously found that 80% of patients presenting to an emergency ...
[34]
Shortness of Breath - Lung and Airway Disorders - Merck Manuals
Causes of Shortness of Breath · Asthma · Pneumonia · Chronic obstructive pulmonary disease (COPD) · A heart attack or angina (chest pain due to inadequate blood ...(dyspnea) · Causes Of Shortness Of... · Lung Disorders
[35]
Heart Failure | Johns Hopkins Medicine
Other heart failure causes include: Arrhythmias: An irregular heartbeat can affect the heart's ability to pump effectively. Cardiomyopathy: This is a disease in ...
[36]
Myocardial Infarction - StatPearls - NCBI Bookshelf - NIH
Aug 8, 2023 · Most myocardial infarctions are due to underlying coronary artery disease, the leading cause of death in the United States. With coronary artery ...
[37]
Salicylate Toxicity - Medscape Reference
May 28, 2024 · The toxic effects of salicylates are complex. Respiratory centers are directly stimulated, causing hyperventilation that results in primary ...Missing: pregnancy | Show results with:pregnancy
[38]
Septic Shock Clinical Presentation: History, Physical Examination ...
Jun 26, 2024 · Hyperventilation with respiratory alkalosis is a common feature of patients with sepsis. This feature results from stimulation of the medullary ...History · Physical Examination · Acute Respiratory Distress...Missing: altitude | Show results with:altitude<|separator|>
[39]
Physiologic Changes at High Altitude - OpenAnesthesia
Oct 29, 2024 · High-altitude exposure triggers hormonal changes that affect fluid balance and cardiovascular responses, including decreased renin-aldosterone activity.
[40]
The Effect of Hyperventilation Syndrome on Ionized and Serum ...
Jul 22, 2023 · Symptoms that characterize HVS are tachypnea, dyspnea, carpopedal spasm, tachypnea, tachycardia, anxiety, and numbness of the extremities, ...Missing: paresthesia | Show results with:paresthesia
[41]
Hyperventilation Syndrome: Symptoms, Causes & Treatment
Mar 29, 2023 · Hyperventilation syndrome happens when you hyperventilate frequently with no underlying physical cause. Episodes can happen due to stress or anxiety or for no ...Missing: females 15-55
[42]
Panic Disorder and Chest Pain: Mechanisms, Morbidity, and ... - NIH
Such hyperventilation or mental stress during a panic attack may result in increased microvascular tone and chest pain in these patients. Co-Occurrence of PD ...
[43]
Hyperventilation - Overview
Symptoms usually last 20 to 30 minutes. They may include: Feeling anxious, nervous, or tense. Frequent sighing or yawning. Feeling that you can't get enough air ...
[44]
Hyperventilation Syndrome Clinical Presentation
Sep 27, 2024 · Carpopedal spasm occurs when acute hypocarbia causes reduced ionized calcium and phosphate levels, resulting in involuntary contraction of the ...Missing: tetany | Show results with:tetany
[45]
Hyperventilation syndrome in adults - UpToDate
Feb 28, 2024 · The hyperventilation syndrome describes a condition in which an inappropriate increase in minute ventilation beyond metabolic needs (ie, in ...<|control11|><|separator|>
[46]
Central and Peripheral Nervous System Responses to Chronic and ...
Patients who chronically hyperventilate appear to be more sensitive to respiratory distress, responding with higher levels of anxiety and poorer tolerance.
[47]
The Hyperventilation Syndrome in Panic Disorder, Agoraphobia and ...
The present study investigates the overlap between DSM-III-R panic disorder, panic disorder with agoraphobia and generalized anxiety disorder with ...Missing: chronic effects sensitivity avoidance
[48]
Hyperventilation - MyHealth Alberta
It occurs more often in women than men. Most people who have it are 15 to 55 years old. It may occur when people travel to elevations over 2000 m (6500 ft).Missing: factors | Show results with:factors
[49]
Hyperventilation Syndrome - an overview | ScienceDirect Topics
The rise in blood pH from the alkalosis produces hypocalcemia, which induces the tetany of muscles and paresthesias. To demonstrate the cause of the spasms, ...
[50]
Severely impaired health-related quality of life in chronic ...
This study shows that HRQoL can be severely impaired in patients with HVS, which is one more reason to take this condition seriously.Missing: healthcare utilization
[51]
Dysfunctional Breathing and Hyperventilation Syndrome - Nature
The global significance of recognising such disorders is underscored by their impact on quality of life and healthcare utilisation, which further ...
[52]
The Nijmegen Questionnaire and dysfunctional breathing - PMC - NIH
May 15, 2015 · The Nijmegen Questionnaire was introduced over 30 years ago as a screening tool to detect patients with hyperventilation complaints that could benefit from ...
[53]
Hyperventilation Syndrome Workup - Medscape Reference
A standard workup for atypical chest pain, including pulse oximetry, chest radiography, and electrocardiography (ECG), may still be warranted depending on the ...
[54]
Capnography and Pulse Oximetry - StatPearls - NCBI Bookshelf - NIH
Capnography is a method of monitoring the concentration or partial pressure of carbon dioxide in the respiratory gases.Continuing Education Activity · Introduction · Function · Clinical Significance
[55]
Hyperventilation Syndrome - Pulmonary Disorders - Merck Manuals
It can be accompanied by agitation and a sense of terror or by symptoms of chest pain, paresthesias (peripheral and perioral), peripheral tetany (eg, stiffness ...Missing: manifestations | Show results with:manifestations
[56]
Hyperventilation Syndrome Treatment & Management
Sep 27, 2024 · In patients who are hyperventilating for organic reasons (eg, pulmonary edema, metabolic acidosis), increasing the arterial partial pressure of ...
[57]
Hyperventilation Symptoms, Causes & Treatment - Cleveland Clinic
Jul 1, 2024 · Hyperventilation happens when you exhale more than you inhale. It causes symptoms like lightheadedness, chest pain and feeling like you're out of breath.Symptoms And Causes · Management And Treatment · Living WithMissing: reliable sources
[58]
Hyperventilation: Causes, Symptoms, and Treatment - Patient.info
Hyperventilation in response to anxiety, which is common. It is more common in women and may be associated with panic disorder. Hyperventilation which may ...<|separator|>
[59]
Breathing exercises for dysfunctional breathing/hyperventilation ...
A significant reduction in the frequency and severity of hyperventilation attacks in the breathing exercise group compared with the control group was reported.
[60]
The Efficacy of Cognitive Behavioral Therapy: A Review of Meta ...
Additionally, CBT significantly alleviated accompanying symptoms of worry and depression when compared to waiting-list control or an active control condition.
[61]
Full article: Cognitive behaviour therapy for social anxiety disorder
Jun 19, 2024 · This review study synthesised the available literature and conducted a meta-analysis to examine the effectiveness of different CBT modalities ( ...Missing: hyperventilation syndrome
[62]
Respiratory biofeedback-assisted therapy in panic disorder - PubMed
The authors describe a new methodologically improved behavioral treatment for panic patients using respiratory biofeedback from a handheld capnometry device.Missing: retraining | Show results with:retraining
[63]
Paced Breathing – Improve your breathing.
Paced Breathing is an iOS and Android app that helps you improve your breathing. You just set your inhale, exhale, and hold times.
[64]
Use of breathing retraining exercises and SSRIs in patients with ...
We believe that SSRI treatment played an acute role in alleviating symptoms of HVS in conjunction with breathing retraining exercises by reducing underlying ...
[65]
Managing Hyperventilation: Best Techniques and Strategies
To manage emotional triggers, it's helpful to include stress-relief activities like meditation, yoga, or deep breathing exercises in your ...
[66]
Hyperventilation: How Yoga Therapy Can Help Overcome Over ...
Apr 24, 2025 · By cultivating mindfulness, yoga therapy helps individuals stay present and engaged in the moment, reducing the tendency to overreact to stress ...
[67]
Prolonged post-hyperventilation apnea in two young adults with ...
Apr 17, 2013 · The prognosis of hyperventilation syndrome (HVS) is generally good. However, it is important to proceed with care when treating HVS because ...
[68]
Hyperventilation, cerebral perfusion, and syncope
This review summarizes evidence in humans for an association between hyperventilation (HV)-induced hypocapnia and a reduction in cerebral perfusion leading ...
[69]
Hyperventilation-Induced Syncope: No Need to Panic - PMC - NIH
Panic attacks and hyperventilation are not synonymous. Hyperventilation rarely accompanies panic, and when it does, it is more likely to be a consequence than ...Missing: mimics | Show results with:mimics
[70]
[PDF] hyperventilation assists proarrhythmia development
Respiratory and metabolic alkalosis lead to hypokalaemia via the 'cation shift'. Since extracellular H+ concentration decreases in alkalosis, a compensatory ...Missing: ectopy | Show results with:ectopy
[71]
Short-coupled Purkinje ectopy inducible by pharmacological and ...
The hyperventilation test has been used in a few previous studies to facilitate the induction of ventricular arrhythmias. Hyperventilation reduces PCO2 values ...
[72]
A case of hyperventilation leading to apnea and desaturation in PACU
Aug 14, 2019 · The hyperventilation was severe enough to cause severe respiratory alkalosis, apnea and desaturation, which is a rare feature in emergence ...
[73]
Hyperventilation | Breathing, Respiration, Anxiety - Britannica
Severe hyperventilation can cause transient loss of consciousness. Related Topics: respiration rate. (Show more). See all related content · Anxiety is the most ...
[74]
Anxiety disorders and cardiovascular disease - PMC - NIH
Diagnosis of anxiety disorders If one relies too heavily on these overlapping symptoms, there is a significant risk of attributing cardiac symptoms to anxiety.
[75]
Common Misdiagnoses of Myocardial Infarction - Clinician.com
May 24, 2009 · Examples of non-cardiac diagnoses include "atypical" chest pain (32%), musculoskeletal pain (21%), and gastrointestinal pain (5%).
[76]
Associations of symptoms of anxiety and depression with health ...
Dec 12, 2022 · We found measures of dyspnoea and dysfunctional breathing to be significantly increased in people who experienced either anxiety or depression ...
[77]
Childhood Respiratory Disease and the Risk of Anxiety Disorder ...
Respiratory disease at age 1 year was associated with significantly increased odds of receiving treatment for anxiety (odds ratio, 2.8; 95% confidence interval, ...Missing: syndrome | Show results with:syndrome
[78]
Hyperventilation syndrome | Supportive Care in Respiratory Disease
The chest pain felt in hyperventilation is typically described as dull and diffuse and is reproducible by palpating the intercostal muscles that are fatigued ...Missing: costochondritis | Show results with:costochondritis
[79]
Hyperventilation and Cerebral Blood Flow
Hypocapnic-hyperventilation, by reducing the cerebral blood volume through cerebral vasoconstriction, can promptly reduce this pressure below a critical ...
[80]
Chronic hyperventilation syndrome associated with syncope and ...
The prognosis of syncope associated with hyperventilation is benign once diagnosed. However, the long-term prognosis for patients with associated coronary ...
[81]
Hyperventilation-induced heart rate response as a potential marker ...
Nov 29, 2019 · A higher resting HR has been shown to be correlated with higher risk of cardiovascular disease and death in the general population and several ...
[82]
[PDF] The relationship between panic disorder and hypertension. A review ...
The authors calculated the relative risk of comorbidity of panic disorder and hypertension as odds ratio (OR) = 3.31 (2.99 – 3.67). Weissman et al.