Fact-checked by Grok 2 weeks ago

Adenitis

Adenitis is the inflammation of a gland, particularly lymph nodes (also known as lymphadenitis), characterized by swelling, tenderness, and often enlargement of the affected tissue due to infection or other inflammatory triggers.^[1]^[2] This condition can occur in various glands throughout the body, including salivary glands (sialadenitis) and, less commonly in humans, sebaceous glands, but lymphadenitis represents the most frequent and clinically significant form.^[3]^[4] The primary causes of adenitis are infectious agents, with bacterial pathogens such as Staphylococcus aureus and Streptococcus pyogenes being common in acute cases, while viruses like adenovirus, enterovirus, and Epstein-Barr virus often trigger self-limiting episodes.^[5]^[6] Other etiologies include fungal infections, mycobacterial diseases (e.g., tuberculosis), or non-infectious factors like autoimmune disorders.^[7] Symptoms typically include localized pain, fever, chills, redness over the gland, and lymph node enlargement exceeding 1 cm in diameter, which may progress to abscess formation if untreated.^[4]^[8] Adenitis manifests in several notable types depending on the anatomical location and underlying cause. Cervical adenitis affects neck lymph nodes and is frequently suppurative, often linked to upper respiratory infections or dental issues in children and adults.^[5] Mesenteric adenitis involves abdominal lymph nodes, mimicking appendicitis with right lower quadrant pain, and is predominantly viral in origin among pediatric patients.^[9]^[10] Sialadenitis, inflammation of the salivary glands, commonly arises from bacterial obstruction or dehydration, presenting with facial swelling and pain during meals.^[3] Tuberculous adenitis, a chronic form, results from Mycobacterium tuberculosis and may require prolonged antimicrobial therapy.^[4] Diagnosis of adenitis relies on clinical evaluation, including history of recent infections and physical examination for tender, enlarged nodes, supplemented by blood tests (e.g., complete blood count showing leukocytosis), imaging (ultrasound or CT for deep nodes), and occasionally biopsy to rule out malignancy or specific pathogens.^[4]^[6] Treatment varies by etiology: viral cases often resolve with supportive care like rest, hydration, and analgesics, while bacterial adenitis requires antibiotics such as clindamycin or amoxicillin-clavulanate, with incision and drainage for abscesses.^[11]^[5] In chronic or mycobacterial instances, extended multidrug regimens or surgical excision may be necessary, emphasizing early intervention to prevent complications like chronic suppuration or systemic spread.^[10]

Overview

Definition

Adenitis refers to the inflammation of a gland or glandular tissue. The term originates from the Greek roots "aden-" (ἀδήν), meaning gland, and "-itis," indicating inflammation.^[1]^[12] Although adenitis can apply to various glands, its common usage in medicine primarily denotes lymphadenitis, the inflammation of one or more lymph nodes, while also encompassing conditions affecting other structures such as sebaceous, salivary, or thyroid glands.^[1]^[2]^[13] Adenitis must be differentiated from adenopathy, which describes the abnormal enlargement of glands or lymph nodes without requisite inflammatory changes, and from abscess formation, a suppurative process involving localized pus accumulation that may complicate untreated adenitis but represents a distinct pathological stage.^[14]^[7]

Epidemiology

Adenitis, encompassing inflammation of various glands but most commonly referring to lymphadenitis, exhibits varying incidence and prevalence globally, influenced by infectious etiologies. In developed countries, palpable lymphadenopathy—a frequent precursor or indicator of lymphadenitis—is estimated to occur in 38-45% of children, making it one of the most common clinical findings in pediatric populations.^[15] Lymphadenitis itself contributes significantly to pediatric outpatient care, particularly cervical forms, which are often self-limited but prompt evaluation in up to one-third of young children due to associated infections.^[16] Prevalence is notably higher in children under 15 years, with mesenteric adenitis—a specific subtype—predominantly affecting those aged 5-14 years and representing up to 20% of cases initially suspected as appendicitis in pediatric emergency settings.^[17] Immunocompromised individuals, including those with HIV or primary immunodeficiencies, face elevated risks, as infections like nontuberculous mycobacteria or Staphylococcus aureus more readily progress to severe lymphadenitis in this group.^[18] Geographic variations underscore the role of endemic infections; for instance, tuberculous lymphadenitis has a prevalence of approximately 4.4 cases per 1,000 children under 14 in rural India, while in sub-Saharan Africa and Southeast Asia, it accounts for 30-40% of peripheral lymphadenopathy cases due to higher tuberculosis burdens.^[19] In contrast, developed regions like the United States and Europe report lower rates of such chronic forms, with acute bacterial lymphadenitis driven more by common pathogens like streptococci.^[15] Key risk factors include young age (peaking in preschool and school-aged children), compromised immune status, and exposure to specific pathogens such as Yersinia enterocolitica in temperate climates or Staphylococcus in community settings, which amplify incidence through increased susceptibility to infectious triggers.^[18]^[17]

Pathophysiology

Inflammatory Mechanisms

Adenitis begins with the initiation of an inflammatory cascade when antigens from pathogens or irritants are recognized by resident immune cells within the glandular tissue, such as macrophages and dendritic cells, leading to the activation of the innate immune system. This recognition prompts the rapid release of pro-inflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α), which amplify the response by recruiting additional immune effectors and inducing local vasodilation.^[20]^[21] These cytokines are primarily secreted by activated macrophages and play a central role in coordinating the inflammatory milieu, as evidenced in glandular inflammations where IL-1 promotes endothelial activation and TNF-α enhances leukocyte adhesion to vascular walls.^[22]^[23] The recruited immune cells, particularly neutrophils and macrophages, infiltrate the glandular parenchyma, contributing to the acute phase of inflammation through phagocytosis and release of reactive oxygen species and additional mediators. Neutrophil infiltration is driven by chemokine gradients established by initial cytokine signaling, resulting in the accumulation of these cells in the interstitium and sinuses of affected glands, such as lymph nodes. Macrophages further exacerbate the process by sustaining cytokine production and antigen presentation, fostering a feedback loop that intensifies local inflammation. In cases of persistent stimulation, this infiltration can lead to tissue remodeling, with hyperplasia of resident cells like lymphocytes and reticuloendothelial elements becoming prominent.^[20]^[24]^[10] As inflammation progresses, cytokine-mediated increases in vascular permeability cause plasma extravasation, resulting in edema that contributes to glandular swelling. Hyperplasia, characterized by proliferation of lymphoid or epithelial cells in response to mitogenic signals from cytokines like IL-1, enlarges the gland and may distort its architecture. In severe acute scenarios, unchecked neutrophil activity can culminate in suppuration, where liquefactive necrosis forms pus-filled abscesses within the gland.^[10]^[17]^[25] Impairment of lymphatic drainage exacerbates glandular engorgement by trapping inflammatory exudate and cells, while vascular changes, including endothelial swelling and thrombosis, further hinder fluid clearance and intensify tenderness through heightened pressure on surrounding tissues. These mechanisms collectively drive the pathological swelling and dysfunction observed in adenitis, with the balance between resolution and chronicity depending on the efficiency of immune clearance.^[24]^[20]^[10]

Affected Glands

Adenitis most commonly affects lymph nodes, which serve as primary sites for immune filtration and response by trapping pathogens and initiating adaptive immunity through lymphocyte activation.^[8]^[26] These small, bean-shaped structures, distributed throughout the body, swell in response to infection or inflammation, reflecting their role in filtering lymph fluid and housing immune cells like B and T lymphocytes.^[27] Mesenteric lymph nodes, located in the abdominal mesentery, exemplify this by providing immune surveillance for the gastrointestinal tract, often becoming inflamed in conditions like mesenteric adenitis due to nearby infections.^[9]^[28] Other glands susceptible to adenitis include salivary glands, where sialadenitis involves inflammation of structures responsible for saliva secretion to aid digestion and oral health.^[3]^[29] The thyroid gland, which regulates metabolism through hormone production, can develop thyroiditis, leading to glandular inflammation that disrupts endocrine function.^[30]^[31] Sebaceous glands, which produce sebum to lubricate and protect the skin, rarely experience adenitis in humans, typically manifesting as localized neutrophilic inflammation on the face or vulva.^[32]^[33] Variations in gland structure influence inflammation patterns; encapsulated glands like lymph nodes and major salivary glands tend to exhibit discrete, contained swelling due to their fibrous capsules that limit spread, whereas more diffuse glandular tissues, such as those in the thyroid, may show broader infiltrative inflammation affecting surrounding parenchyma.^[34]^[35] This structural difference can determine the localized versus systemic nature of adenitic responses.^[36]

Causes

Infectious Causes

Infectious causes of adenitis, particularly lymphadenitis, are primarily due to microbial invasion that triggers an inflammatory response in lymph nodes, leading to their enlargement and tenderness. These infections can result from direct inoculation through skin breaks, hematogenous dissemination from a primary site, or contiguous spread from adjacent infected tissues.^[18] Common pathogens include bacteria, viruses, fungi, and parasites, with the specific agents often determined by the patient's immune status, geographic location, and exposure history.^[18] Bacterial infections are the most frequent cause of acute lymphadenitis, often presenting as localized or regional node involvement. Staphylococcus aureus is a leading pathogen, typically entering via skin or soft tissue infections and causing suppurative adenitis through direct inoculation or contiguous spread; it accounts for a significant portion of cases in both children and adults, with methicillin-resistant strains complicating treatment in community settings.^[18] Streptococcus species, particularly Streptococcus pyogenes, commonly cause acute cervical lymphadenitis following pharyngitis or skin infections, where bacterial spread to draining lymph nodes provokes a rapid inflammatory response via toxin-mediated tissue damage and immune activation.^[18] Yersinia enterocolitica is associated with mesenteric adenitis, mimicking appendicitis; transmission occurs via ingestion of contaminated food or water, leading to ileal infection and subsequent hematogenous or lymphatic spread to abdominal nodes, resulting in hyperplasia and inflammation.^[37] Chronic bacterial adenitis is exemplified by Mycobacterium tuberculosis, causing scrofula or tuberculous lymphadenitis, primarily in the cervical chain; airborne transmission from respiratory droplets initiates primary pulmonary infection, followed by hematogenous dissemination to nodes, where granulomatous inflammation develops due to cell-mediated immune response. Viral infections typically produce reactive, generalized lymphadenitis without suppuration, driven by systemic immune activation. Epstein-Barr virus (EBV), transmitted through saliva, causes infectious mononucleosis with prominent cervical and generalized adenopathy; viral replication in B lymphocytes induces T-cell proliferation and cytokine release, enlarging nodes.^[18] Cytomegalovirus (CMV), spread via bodily fluids, similarly leads to mononucleosis-like illness with lymphadenopathy in both immunocompetent and immunocompromised individuals, through endothelial cell infection and subsequent immune hyperplasia.^[18] Human immunodeficiency virus (HIV) results in persistent generalized lymphadenopathy early in infection, transmitted sexually or via blood; it depletes CD4+ T cells while initially hyperactivating lymphoid tissue, causing follicular hyperplasia.^[18] Fungal and parasitic infections more commonly affect immunocompromised hosts, such as those with HIV/AIDS or on immunosuppressive therapy, leading to disseminated disease with nodal involvement. Histoplasma capsulatum, acquired by inhalation of spores from soil or bat guano, causes mediastinal and generalized adenitis; in immunocompromised patients, it disseminates hematogenously, forming granulomas in lymph nodes due to macrophage infection and poor containment.^[38] Toxoplasma gondii, transmitted via undercooked meat or oocysts in contaminated water, induces cervical or generalized lymphadenitis; in immunocompromised individuals, tachyzoite proliferation evades immune control, causing necrotizing inflammation in nodes.^[39]

Non-Infectious Causes

Non-infectious causes of adenitis involve sterile inflammatory processes driven by immune dysregulation, malignancy, or external triggers, contrasting with the more prevalent pathogen-mediated etiologies. These conditions often present with glandular swelling and tenderness but require differentiation through histopathological or serological evaluation to exclude infection.^[18] Autoimmune disorders represent a primary category of non-infectious adenitis, where aberrant immune responses target glandular tissues. Sjögren's syndrome, a systemic autoimmune condition, frequently manifests as chronic lymphocytic sialadenitis affecting the salivary glands, leading to focal lymphocytic infiltration and glandular dysfunction. This infiltration correlates with sicca symptoms and can be confirmed via minor salivary gland biopsy showing focus scores indicative of the disease.^[40]^[41] Sarcoidosis, another autoimmune-mediated process, causes granulomatous lymphadenitis characterized by noncaseating epithelioid granulomas in lymph nodes, often involving cervical or hilar regions without identifiable infectious triggers. The etiology remains idiopathic, though genetic and environmental factors contribute, and it carries a generally favorable prognosis in isolated nodal involvement.^[42]^[43] Neoplastic processes can induce secondary adenitis through direct glandular infiltration or reactive inflammation. Lymphomas, including Hodgkin and non-Hodgkin variants, commonly cause lymphadenopathy with inflammatory features due to tumor cell proliferation within nodes, mimicking infectious adenitis on initial presentation. Metastatic cancers, such as those from head and neck primaries or distant sites like breast or lung, similarly provoke nodal inflammation via tumor emboli or cytokine release, often presenting as firm, fixed masses.^[7]^[18] Idiopathic or reactive non-infectious adenitis arises from hypersensitivity or mechanical insults without underlying autoimmunity or malignancy. Drug reactions, exemplified by phenytoin, trigger pseudolymphomatous lymphadenopathy with follicular hyperplasia and inflammatory infiltrates, typically resolving upon discontinuation but occasionally mimicking lymphoma. Trauma to glandular tissues, such as blunt injury to the neck or oral structures, can result in hemorrhagic or reactive lymphadenitis, with swelling due to hematoma formation and secondary inflammation.^[44]^[45] Rare non-infectious causes include allergic hypersensitivity and endocrine influences on glandular function. Allergic reactions, such as iodinated contrast-induced sialadenitis (iodine mumps), cause acute, painless swelling of salivary glands through iodide accumulation and osmotic effects, usually self-limiting within 24-48 hours. Endocrine disorders, including diabetes mellitus, may contribute to sialadenitis via xerostomia and reduced salivary flow, predisposing glands to inflammatory stasis without direct microbial involvement.^[46]^[29]

Clinical Presentation

General Symptoms

Adenitis, or inflammation of a gland such as a lymph node, typically presents with localized signs of inflammation over the affected area. These include swelling of the gland, tenderness to palpation, increased warmth, and erythema of the overlying skin.^[6]^[14] The swollen glands are often painful, particularly during acute episodes, and may exhibit fluctuance if an abscess develops.^[47] In acute cases, systemic symptoms frequently accompany the local findings, including fever, malaise, and chills.^[14]^[26] These manifestations reflect the body's immune response to infection or inflammation and can vary in severity depending on the underlying cause.^[18] Affected lymph nodes in adenitis often have a rubbery or firm consistency upon palpation and remain mobile beneath the skin, distinguishing them from fixed or matted nodes seen in other conditions.^[47]^[24] This mobility typically persists unless adhesions form due to prolonged inflammation. Site-specific variations may influence the prominence of certain symptoms, but the core features remain consistent across locations.^[8] The temporal pattern of adenitis helps differentiate acute from chronic forms: acute adenitis features sudden onset and resolves within less than 2 weeks, while chronic adenitis persists beyond 4 weeks, often with subtler or recurrent symptoms.^[18]^[48]

Location-Specific Manifestations

Adenitis manifestations vary significantly depending on the anatomical location of the affected glands, influencing local symptoms and associated discomfort. In the cervical or neck region, inflammation of lymph nodes often leads to pain on swallowing, known as odynophagia, and jaw stiffness, particularly when submandibular nodes are involved, as these symptoms arise from localized swelling and tenderness compressing nearby structures.^[49]^[50] This presentation is commonly linked to concurrent upper respiratory infections, such as those causing sore throat or cough, which trigger reactive lymphadenitis.^[26]^[51] Mesenteric adenitis in the abdominal region typically causes acute right lower quadrant pain that can mimic appendicitis, accompanied by nausea, vomiting, and diarrhea due to inflammation of lymph nodes in the mesentery.^[9]^[10] These symptoms result from the proximity of inflamed nodes to the intestines, leading to irritation and gastrointestinal upset, often in the context of a viral illness.^[52] Axillary adenitis, involving lymph nodes in the armpit, may produce skin changes such as redness and tenderness over the affected area, especially when secondary to nearby infections like those in the breast or upper extremity.^[53] Similarly, inguinal adenitis in the groin region can lead to overlying skin alterations, including erythema and warmth, typically arising from infections in the lower extremities, anogenital area, or pelvic structures.^[54]^[6] Salivary gland adenitis, or sialadenitis, frequently manifests with dry mouth, or xerostomia, due to impaired saliva production from ductal obstruction or inflammation, often exacerbated by eating and accompanied by facial swelling or pain.^[55]^[56] Sebaceous adenitis, a rare condition in humans also known as neutrophilic or vulvar sebaceous adenitis and primarily affecting young women, presents with recurrent tender papules, nodules, or circinate plaques on the vulva or face, sometimes with purulent discharge.^[33]^[57]^[32]

Diagnosis

History and Physical Examination

The evaluation of suspected adenitis begins with a thorough patient history to identify potential underlying factors contributing to glandular inflammation. Clinicians should inquire about recent infections or exposures to ill individuals, as these are common precipitants of reactive adenitis, particularly in cases of bacterial or viral lymphadenitis. Travel history is essential to assess for endemic infections, such as tuberculosis or parasitic diseases, which may manifest as adenitis in travelers from high-risk regions. Immune status, including any history of immunosuppression (e.g., HIV or chemotherapy), must be evaluated, as immunocompromised patients are at higher risk for opportunistic infections leading to adenitis. Additionally, current medications, such as those causing drug-induced hypersensitivity reactions, and family history of autoimmune diseases should be documented to guide differential considerations.^[58]^[7]^[59] Physical examination focuses on systematic palpation and inspection of affected glands to characterize the adenitis. Nodes or glands greater than 1 cm in diameter are generally considered enlarged and warrant further attention, though thresholds vary by location (e.g., supraclavicular nodes >0.5 cm). Tenderness upon palpation suggests an acute inflammatory process, while fixation to underlying tissues indicates possible chronic or invasive pathology. Inspection for overlying skin changes, such as erythema, warmth, or ulceration, helps differentiate infectious from non-infectious causes. A complete exam should include assessment of all nodal basins to determine if the adenitis is localized or generalized.^[7]^[18]^[59]^[60] Certain findings during history and physical examination serve as red flags prompting urgent evaluation for serious conditions. Unintentional weight loss, persistent adenitis lasting more than 4 weeks, or involvement of supraclavicular nodes are concerning for malignancy, such as lymphoma or metastatic disease. The presence of constitutional symptoms like fever, night sweats, or fatigue in conjunction with these features further heightens suspicion.^[18]^[61]^[62] Differential diagnosis based on history and examination primarily distinguishes between infectious adenitis (e.g., bacterial or viral), malignancy, and reactive hyperplasia. For instance, acute onset with tenderness often points to infection, whereas hard, fixed nodes without tenderness raise concern for neoplasm. Reactive hyperplasia may be suggested by a history of recent vaccination or minor trauma. These clinical features help prioritize subsequent investigations without relying on confirmatory tests.^[7]^[48]

Diagnostic Tests

Diagnostic tests for adenitis, particularly lymphadenitis, are essential to confirm inflammation, assess severity, and identify underlying etiologies such as infection or malignancy. These tests typically follow initial clinical evaluation and are selected based on symptoms like fever or localized swelling to guide targeted investigations. Laboratory studies provide initial systemic insights, while imaging and invasive procedures offer anatomical and microbiological confirmation. Blood tests form the cornerstone of initial laboratory evaluation. A complete blood count (CBC) often reveals leukocytosis, indicating an acute inflammatory or infectious process, particularly in bacterial causes.^[18] Elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) serve as non-specific markers of inflammation, with CRP being more sensitive for acute changes.^[18] Blood cultures are recommended in cases of suspected bacteremia, while serologic testing, such as IgM antibodies for Epstein-Barr virus (EBV), helps identify viral etiologies like infectious mononucleosis.^[8] Imaging modalities are crucial for visualizing gland involvement and differentiating adenitis from complications like abscesses or neoplasms. Ultrasound is the preferred first-line imaging due to its non-invasive nature, allowing assessment of node architecture, size, echogenicity, and vascularity via Doppler to distinguish reactive from malignant nodes.^[63] For deeper or abdominal glands, computed tomography (CT) or magnetic resonance imaging (MRI) provides detailed evaluation, identifying necrosis, abscess formation, or extension into surrounding tissues, with CT being particularly useful for mesenteric adenitis.^[47] Invasive procedures are employed when non-invasive tests are inconclusive or malignancy is suspected. Fine-needle aspiration (FNA) biopsy enables cytological examination, microbial culture from aspirate, and identification of features like granulomas in tuberculous adenitis.^[18] Excisional biopsy, considered the gold standard for tissue diagnosis, is performed for persistent or atypical cases to allow comprehensive histological analysis.^[18] Specialized tests target specific etiologies. The Mantoux tuberculin skin test (TST) is used to screen for tuberculosis in endemic areas or with compatible clinical features, though it requires confirmation with biopsy if positive.^[64] Flow cytometry on aspirated material aids in evaluating for lymphoma when nodes show suspicious features like rapid growth or B-symptoms.^[47]

Management

Supportive Measures

Supportive measures for adenitis primarily aim to alleviate symptoms and promote natural resolution, particularly in cases of uncomplicated lymphadenitis caused by viral infections or mild bacterial processes. These interventions are non-invasive and can be implemented at home under medical guidance. Pain management is a cornerstone of supportive care, with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen recommended to reduce tenderness, swelling, and associated fever. Over-the-counter options like ibuprofen (Advil, Motrin IB) or naproxen sodium (Aleve) are commonly advised for adults, while acetaminophen (Tylenol) serves as an alternative for pain relief, especially in children to avoid the risks associated with NSAIDs. Aspirin should be avoided in pediatric patients due to the potential for Reye's syndrome.^[60]^[11] Rest and adequate hydration are essential, particularly for individuals experiencing systemic symptoms such as fever or malaise, and are especially beneficial in children with viral etiologies like mesenteric adenitis. Encouraging sufficient rest allows the body's immune response to target the inflammation, while fluid intake prevents dehydration exacerbated by fever or reduced appetite. A light liquid diet, such as broths, may further support comfort during acute episodes.^[11]^[18] Applying warm compresses to the affected area can help reduce localized swelling and provide symptomatic relief for superficial lymph nodes. A warm, moist washcloth applied several times daily for 10-15 minutes is a simple, effective method to improve comfort without promoting further inflammation.^[60]^[11] Outpatient monitoring is crucial to ensure resolution, with follow-up recommended within 2-4 weeks if symptoms persist or worsen, allowing for timely reassessment and adjustment based on etiology-specific needs. Patients should track symptom progression and report any signs of complications, such as increasing node size or systemic illness.^[58]^[18]

Targeted Treatments

Targeted treatments for adenitis address the underlying etiology to resolve inflammation and prevent complications, tailored to whether the condition stems from bacterial, viral, fungal, autoimmune, or malignant causes.^[65] For bacterial adenitis, antibiotic therapy is the cornerstone, selected based on the suspected pathogen and local resistance patterns. In cases of staphylococcal or streptococcal lymphadenitis, first-generation cephalosporins such as cephalexin (25-50 mg/kg/day divided every 6-8 hours for 7-10 days) are commonly prescribed for methicillin-sensitive strains, while clindamycin (20-40 mg/kg/day divided every 6-8 hours) serves as a first-line option in regions with high methicillin-resistant Staphylococcus aureus prevalence to cover both aerobic and anaerobic bacteria.^[66]^[67] For tuberculous adenitis, known as scrofula, a standard six-month anti-tuberculosis regimen is employed, beginning with an intensive phase of isoniazid (5 mg/kg/day, max 300 mg), rifampin (10 mg/kg/day, max 600 mg), pyrazinamide (15-30 mg/kg/day, max 2 g), and ethambutol (15-25 mg/kg/day, max 1 g) for two months, followed by a continuation phase of isoniazid and rifampin for four months, achieving cure rates exceeding 95% in confirmed cases.^[68] Viral and fungal etiologies require specific antimicrobials in targeted scenarios. Acyclovir, administered orally at 20 mg/kg/dose (maximum 400 mg/dose) every 8 hours for 5-7 days in children or 400 mg five times daily in adults, or intravenously at 5-10 mg/kg every 8 hours for severe cases, effectively treats herpes simplex virus-associated lymphadenitis by inhibiting viral DNA polymerase, leading to rapid resolution of nodal inflammation and associated symptoms within days.^[69]^[70] In immunocompromised patients with fungal adenitis, such as disseminated candidiasis or histoplasmosis involving lymph nodes, liposomal amphotericin B (3-5 mg/kg/day intravenously) is the preferred initial therapy due to its broad-spectrum activity against invasive fungi, often continued until clinical improvement before transitioning to oral azoles like itraconazole.^[71] Surgical interventions provide definitive management for suppurative or persistent cases unresponsive to medical therapy. Incision and drainage, guided by ultrasound when possible, is indicated for abscess formation in acute bacterial adenitis to evacuate pus and facilitate antibiotic penetration, with studies showing reduced recurrence rates compared to aspiration alone in pediatric suppurative cervical lymphadenitis.^[72] For chronic adenitis, such as nontuberculous mycobacterial infections, complete surgical excision of affected nodes may be necessary to eradicate residual disease, particularly if medical therapy fails. In neoplastic adenitis, like lymphoma, surgical biopsy confirms diagnosis, but excision is reserved for localized disease or complications, with broader resection avoided in favor of systemic therapy.^[73] Immunomodulatory and antineoplastic agents target autoimmune or malignancy-driven adenitis. Corticosteroids, such as prednisone (0.5-1 mg/kg/day tapered over weeks), are used for autoimmune sialadenitis in conditions like Sjögren's syndrome to suppress glandular inflammation during acute flares, though long-term use is limited due to side effects and reserved for severe extraglandular involvement.^[74] For malignancy-associated adenitis, such as non-Hodgkin lymphoma, chemotherapy regimens like R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) administered in 21-day cycles form the mainstay, achieving complete remission in over 70% of diffuse large B-cell lymphoma cases with nodal presentation.^[75] These targeted approaches may complement supportive measures like analgesics for symptom control.^[6]

Classification

By Location

Adenitis encompasses inflammation of various glands or lymph nodes, and its classification by anatomical location helps guide clinical evaluation and differential diagnosis, as the site often correlates with specific infectious or inflammatory triggers and symptom patterns. Among lymph node adenitis (lymphadenitis), the cervical region in the neck is the most prevalent site, particularly in pediatric populations where it accounts for over 90% of presentations in children aged 4 to 8 years, often linked to upper respiratory infections.^[16] In broader cohorts including adults, cervical involvement remains dominant, comprising approximately 57% of cases.^[76] Axillary adenitis, affecting lymph nodes in the armpit, is less common and typically arises from infections or injuries in the upper extremities. Inguinal adenitis involves groin nodes and is associated with lower extremity or genitourinary infections. Mesenteric adenitis targets abdominal lymph nodes and is notable for its occurrence in children, where it frequently presents with right lower quadrant pain.^[10] Non-lymphatic forms of adenitis affect specialized glands. Sialadenitis refers to inflammation of the salivary glands, most commonly the parotid or submandibular, often due to bacterial ascent from the oral cavity or ductal obstruction.^[3] Thyroiditis involves the thyroid gland in the neck and encompasses various subtypes, including acute suppurative and autoimmune forms like Hashimoto's thyroiditis, leading to glandular swelling and potential hormonal disruption.^[30] Sebaceous adenitis, a rare inflammatory condition targeting sebaceous (oil-producing) skin glands, primarily manifests as neutrophilic or vulvar variants in humans, resulting in localized plaques or nodules.^[32] The location of adenitis significantly influences diagnostic considerations; for instance, mesenteric adenitis commonly mimics acute appendicitis, prompting imaging to differentiate it from surgical emergencies.^[9] Similarly, cervical or axillary sites may suggest regional infections, while glandular adenitis like sialadenitis requires evaluation for obstructive calculi.^[29] This spatial classification underscores the importance of anatomical context in narrowing etiologic possibilities without overlapping with causal factors.

By Etiology

Adenitis, or lymphadenitis, is classified by etiology into infectious and non-infectious categories, with further distinctions based on the causative agent or underlying mechanism. Infectious etiologies predominate in acute presentations and involve direct microbial invasion or immune response to pathogens, while non-infectious causes often reflect systemic immune dysregulation or malignancy-related processes.^[47]^[7] Infectious adenitis encompasses bacterial, viral, and mycobacterial subtypes. Bacterial adenitis typically manifests as acute suppurative inflammation, characterized by pus formation and rapid nodal enlargement due to pathogens such as Staphylococcus aureus or group A Streptococcus, which trigger neutrophilic infiltration and abscess development.^[24]^[47] Viral adenitis is generally reactive, involving lymphoid hyperplasia without suppuration, often secondary to viruses like Epstein-Barr virus or cytomegalovirus, which provoke B-cell proliferation and follicular expansion as part of the host immune response.^[24]^[7] Mycobacterial adenitis, such as that caused by Mycobacterium tuberculosis or atypical mycobacteria, presents as granulomatous inflammation with caseating necrosis, reflecting a cell-mediated immune reaction that forms epithelioid histiocytes and multinucleated giant cells.^[24]^[47] Non-infectious adenitis includes autoimmune, neoplastic, and idiopathic forms. Autoimmune adenitis arises from dysregulated immune responses, as seen in IgG4-related disease, where infiltration of IgG4-positive plasma cells leads to fibroinflammatory changes and nodal enlargement through storiform fibrosis and obliterative phlebitis.^[77]^[7] Neoplastic adenitis may occur as paraneoplastic phenomena, in which an underlying malignancy induces reactive lymphadenopathy via cytokine release or autoimmune cross-reactivity, distinct from direct tumor infiltration.^[78]^[47] Idiopathic adenitis lacks a identifiable cause and includes entities like Kikuchi-Fujimoto disease, marked by histiocytic necrotizing lymphadenitis without neutrophils.^[24]^[7] Adenitis is further delineated as acute or chronic based on duration and clinical response. Acute adenitis is defined by onset and persistence less than 2 weeks, often resolving with treatment of the underlying trigger, whereas chronic adenitis endures beyond 4 weeks, potentially indicating persistent infection, malignancy, or autoimmune processes with incomplete resolution.^[7] Overlaps between etiologies occur, particularly in post-infectious autoimmune adenitis, where an initial microbial insult, such as a viral infection, triggers subsequent autoimmune-mediated nodal inflammation, as in cases evolving into conditions like Kikuchi disease.^[24]^[7] Location may influence suspicion of specific etiologies, guiding initial diagnostic considerations.^[47]

References

[1]
ADENITIS Definition & Meaning - Merriam-Webster
The meaning of ADENITIS is inflammation of a gland; especially : lymphadenitis.
[2]
Medical Definition of Adenitis - RxList
Adenitis: Inflammation of a lymph gland. From the aden-, gland + -itis, inflammation.
[3]
Sialadenitis (Salivary Gland Infection): Symptoms & Treatment
Sialadenitis is the medical term for a swollen salivary gland. Infection, autoimmune disorders and salivary gland stones can cause the condition.
[4]
What is Adenitis? Swollen Lymph Nodes from Lymphadenitis
Adenitis, a general term for lymphadenitis, is an inflammation of the lymphatic system that results in the enlargement of one or more lymph nodes due to an ...
[5]
Adenitis - an overview | ScienceDirect Topics
Common pathogens include rhinovirus, adenovirus, and enterovirus, but measles, mumps, rubella, varicella, EBV, and cytomegalovirus may also cause ...
[6]
Lymphadenitis: MedlinePlus Medical Encyclopedia
May 19, 2023 · Lymphadenitis is an infection of the lymph nodes (also called lymph glands). It is a complication of certain bacterial infections.
[7]
Adenopathy - StatPearls - NCBI Bookshelf - NIH
Lymphadenopathy refers to the swelling of lymph nodes which can be secondary to bacterial, viral, or fungal infections, autoimmune disease, and malignancy.
[8]
Lymphadenitis | Johns Hopkins Medicine
Lymphadenitis occurs when one or more lymph nodes are infected by bacteria, a virus, or a fungus. When lymph nodes become infected, it's often because an ...
[9]
Mesenteric lymphadenitis - Symptoms and causes - Mayo Clinic
Jan 10, 2024 · Lymphadenitis is a condition in which the small round or bean-shaped clusters of cells, called lymph nodes, become swollen and inflamed.
[10]
Mesenteric Adenitis - StatPearls - NCBI Bookshelf - NIH
Aug 8, 2023 · Mesenteric adenitis is a syndrome characterized by right lower quadrant pain secondary to an inflammatory condition of mesenteric lymph nodes.
[11]
Mesenteric lymphadenitis - Diagnosis and treatment - Mayo Clinic
Jan 10, 2024 · Treatment. Mild cases of mesenteric lymphadenitis and those caused by a virus usually go away on their own. Full recovery can take four weeks ...
[12]
Adenitis | definition of adenitis by Medical dictionary
[ad″ĕ-ni´tis] inflammation of a gland. cervical adenitis a condition characterized by enlarged, inflamed, and tender lymph nodes of the neck; seen in certain ...Missing: Stedman's | Show results with:Stedman's
[13]
https://www.oxfordreference.com/display/10.1093/oi/authority.20110810104318703
[14]
Lymphadenitis - Dermatologic Disorders - Merck Manuals
Lymphadenitis typically causes pain, tenderness, and lymph node enlargement. Pain and tenderness typically distinguish lymphadenitis from lymphadenopathy.Missing: adenopathy | Show results with:adenopathy
[15]
Lymphadenopathy: Practice Essentials, Pathophysiology ...
Mar 21, 2024 · The precise incidence of lymphadenopathy is not known, but estimates of palpable adenopathy in childhood vary from 38-45%, and lymphadenopathy ...
[16]
Pediatric Cervical Lymphadenopathy - AAP Publications
Sep 1, 2018 · Cervical lymphadenopathy affects as many as 90% of children aged 4 to 8 years. With so many children presenting to doctors' offices and ...
[17]
Mesenteric Lymphadenitis: Background, Pathophysiology, Etiology
Oct 18, 2025 · Secondary mesenteric lymphadenitis is caused by inflammatory processes (eg, Crohn disease , infectious ileitis, systemic lupus erythematosus ) ...
[18]
Lymphadenopathy - StatPearls - NCBI Bookshelf
Lymphadenopathy, or adenopathy, is a common abnormal finding during the physical exam in general medical practice. Patients and physicians have varying ...Missing: adenitis | Show results with:adenitis<|control11|><|separator|>
[19]
Tuberculous lymphadenitis - UpToDate
May 22, 2025 · In rural India, the prevalence of tuberculous lymphadenitis in children up to 14 years of age is approximately 4.4 cases per 1000 [3].
[20]
Lymphadenitis - an overview | ScienceDirect Topics
Lymphadenitis refers to an influx of inflammatory cells (neutrophils, eosinophils, or macrophages) into lymph nodes, often secondary to the drainage of by- ...Lymphadenitis And... · Pathogenesis And Pathologic... · Etiologic Agents And...
[21]
Inflammatory responses and inflammation-associated diseases in ...
Stimuli activate inflammatory cells, such as macrophages and adipocytes, and induce production of inflammatory cytokines, such as IL-1β, IL-6, TNF-α, and ...Missing: glandular adenitis
[22]
Expression of interleukin-1 beta, interleukin-6 and tumour necrosis ...
TNF alpha expression was demonstrated in macrophages from seven of 11 dogs with mineral-associated lymphadenopathy, one of five dogs with granulomatous ...
[23]
Macrophage Cytokines: Involvement in Immunity and ... - Frontiers
When macrophages are exposed to inflammatory stimuli, they secrete cytokines such as tumor necrosis factor (TNF), IL-1, IL-6, IL-8, and IL-12. Although ...Missing: glandular adenitis
[24]
Lymphadenitis: Practice Essentials, Pathophysiology, Etiology
Apr 4, 2024 · Lymphadenitis is the inflammation or enlargement of a lymph node. Lymph nodes are small, ovoid nodules normally ranging in size from a few millimeters to 2 cm.
[25]
https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688212/all/Mesenteric_Adenitis
[26]
Swollen lymph nodes - Symptoms & causes - Mayo Clinic
Apr 25, 2025 · Swollen lymph nodes most often happen because of infection from bacteria or viruses. Rarely, cancer causes swollen lymph nodes.Missing: adenitis | Show results with:adenitis
[27]
Swollen Lymph Nodes - Cleveland Clinic
Sep 3, 2025 · Swollen lymph nodes are lumps of tissue in certain body areas that feel bigger or painful. Their swelling is part of your body's natural ...Missing: types | Show results with:types
[28]
Mesenteric Lymphadenitis: Symptoms, Causes, Tests and Treatments
Mesenteric lymphadenitis, also known as mesenteric adenitis, is inflammation (swelling) of the lymph nodes in the abdomen (belly). Lymph nodes are organs that ...
[29]
Submandibular Sialadenitis and Sialadenosis - StatPearls - NCBI
Submandibular sialadenitis is characterized by inflammation due to salivary stasis, leading to bacterial infection from the oral cavity.Etiology · Pathophysiology · History And Physical<|separator|>
[30]
Thyroiditis: Types, Causes, Symptoms, Diagnosis & Treatment
Thyroiditis is inflammation of your thyroid gland, which is a small, butterfly-shaped gland located at the front of your neck under your skin.
[31]
Causes of thyroiditis - American Thyroid Association
Thyroiditis is a general term that refers to “inflammation of the thyroid gland”. Thyroiditis includes a group of individual disorders causing thyroidal ...
[32]
Neutrophilic sebaceous adenitis - DermNet
Neutrophilic sebaceous adenitis is a rare inflammatory dermatosis that most commonly affects the face and torso of young men.
[33]
Sebaceous adenitis of the vulva responsive to antiandrogens - PMC
Jun 4, 2018 · Sebaceous adenitis is an inflammatory dermatosis most commonly reported in animals. There have been rare reports in humans, mostly on the ...
[34]
Lymphoid tissue | Definition, Components, & Function - Britannica
The most highly organized lymphoid tissues are in the thymus and lymph nodes, which are well-defined encapsulated organs with easily identifiable architectures.
[35]
Lymph Node - an overview | ScienceDirect Topics
Lymph nodes are bean-shaped, encapsulated structures ... Many lymph nodes are ellipsoidal and retain this shape during enlargement by inflammation or malignant ...
[36]
Thyroiditis - StatPearls - NCBI Bookshelf
Thyroiditis is a condition that occurs when the thyroid gland gets inflamed. The thyroid gland is responsible for making a hormone called thyroxine, which ...
[37]
Yersinia Enterocolitica - StatPearls - NCBI Bookshelf
Yersinia infections can present with enterocolitis, pseudoappendicitis, reactive arthritis, sepsis, pharyngitis, myocarditis, mesenteric adenitis or dermatitis.
[38]
Histoplasma capsulatum presenting as generalized ...
Histoplasma capsulatum is typically an indolent disease among immunocompetent patients. However, immunocompromised patients, such as solid organ transplant ...
[39]
Toxoplasma Lymphadenopathy - PubMed Central - NIH
While those who are immunocompromised, a multisystemic form can develop, with multiorgans involvement, like the cardiac, CNS, lungs, and ocular signs (7).
[40]
Approach to sialadenitis - PMC - NIH
The primary autoimmune disease associated with sialadenitis is Sjögren syndrome, a condition characterized by hypofunction of the salivary and lacrimal glands.Figure 1 · Symptoms And Causes · Figure 2Missing: adenitis | Show results with:adenitis<|separator|>
[41]
A postmortem study of focal adenitis in salivary and lacrimal glands
A focus score exceeding 1 may be an indicator of Sjögren's syndrome, but the diagnosis should not be established on the biopsy findings alone.
[42]
Granulomatous lymphadenitis - PubMed
Noninfectious GLA includes sarcoidosis and sarcoid-like reaction. The cause of sarcoidosis remains unknown, but it has good prognosis. Sarcoid-like reaction, ...
[43]
The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis
Sarcoidosis is a granulomatous inflammation that has no identifiable cause, such as an infection or a foreign body. It is thus a diagnosis of exclusion.
[44]
Phenytoin-induced lymphadenopathy - PubMed
Various lymph node abnormalities have been associated with phenytoin therapy. Four distinct categories of lymphadenopathy have been described.
[45]
Traumatic Haemorrhagic Cervical Lymphadenopathy with ... - NIH
Lymphadenopathy as a result of trauma is quite rare with only a handful of case reports in the literature [3, 4]. Haemorrhagic lymphadenopathy classically ...Missing: induced adenitis
[46]
Iodinated contrast-induced sialadenitis: a review of the literature and ...
Swelling of the salivary glands, also known as iodide or iodine mumps, is a rare adverse reaction to administration of iodine, a component steadily present ...Missing: adenitis | Show results with:adenitis
[47]
Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis
Dec 1, 2016 · Lymph node qualities include warmth, overlying erythema, tenderness, mobility, fluctuance, and consistency. Shotty lymphadenopathy is the ...
[48]
Management of Infectious Lymphadenitis in Children - PMC
The most frequent noninfectious causes of lymphadenopathy are medications, malignancy, immunologic disorders, or Kawasaki disease [7,23]. Contact with animals ...7. Subacute Infectious... · 7.1. Nontuberculous... · Table 3Missing: immune | Show results with:immune
[49]
Deep Neck Infections - StatPearls - NCBI Bookshelf
Aug 11, 2024 · Deep neck infections commonly arise from local extensions of infections in the tonsils, parotid glands, cervical lymph nodes, and odontogenic ...
[50]
[PDF] A Pain in the Neck - Scholarly Commons
Oct 7, 2015 · ▫ Localized symptoms of dysphagia, voice changes (duck quacking sound), odynophagia, trismus, and neck/jaw pain. – Pain with side to side ...
[51]
Childhood cervical lymphadenopathy - PMC - PubMed Central - NIH
Associated symptoms. Fever, sore throat, and cough suggest an upper respiratory tract infection. Fever, night sweats, and weight loss suggest lymphoma or ...
[52]
Acute Nonspecific Mesenteric Lymphadenitis: More Than “No Need ...
Jan 17, 2017 · Acute nonspecific, or primary, mesenteric lymphadenitis is a self-limiting inflammatory condition affecting the mesenteric lymph nodes.
[53]
Lymphedema - Symptoms and causes - Mayo Clinic
Nov 24, 2022 · Lymphedema is swelling in an arm or a leg. In rare circumstances, it affects both arms or both legs. It can also affect the chest wall and ...Missing: axillary | Show results with:axillary
[54]
Anatomy, Abdomen and Pelvis: Inguinal Lymph Node - NCBI - NIH
Swollen lymph nodes usually indicate infection from bacteria or viruses. Swollen inguinal lymph nodes could indicate an infection of areas of the lower body.
[55]
Sialadenitis | McGovern Medical School
Jan 9, 2020 · Sialadenitis is inflammation and enlargement of one or more of the salivary (spit) glands. The salivary glands are responsible for producing and storing saliva.
[56]
Salivary gland infections: MedlinePlus Medical Encyclopedia
Sep 10, 2023 · Symptoms. Symptoms include: Abnormal tastes, foul tastes. Decreased ability to open the mouth.
[57]
Sebaceous adenitis - PubMed
A 32-year-old man had an asymptomatic erythematous, annular and circinate eruption on the face for 2 months. Histologic examination revealed sebaceous lobules.Missing: symptoms | Show results with:symptoms
[58]
Acute, subacute, and chronic cervical lymphadenitis in children - PMC
Lymphadenitis specifically refers to lymphadenopathies that are caused by inflammatory processes. Cervical lymphadenopathy is a common problem in the pediatric ...
[59]
Peripheral Lymphadenopathy: Approach and Diagnostic Tools - PMC
Some important causes include the Epstein-Barr virus, HIV, lymphoma, and autoimmune disorders. Ultrasound can assess the number, size, site, shape, margins, ...
[60]
Swollen lymph nodes - Diagnosis & treatment - Mayo Clinic
Apr 25, 2025 · The usual treatment for swollen lymph nodes caused by a bacterial infection is antibiotics. Swollen lymph nodes that are due to an HIV infection ...Missing: adenitis | Show results with:adenitis
[61]
Lymphadenopathy in the rheumatology practice: a pragmatic ... - NIH
Lymph nodes are often significantly enlarged (2–4 cm, up to 6+ cm) and, although UCD can occur in any lymph node station, the most commonly involved regions ...Missing: concerning | Show results with:concerning
[62]
Lymphadenopathy - Clinical Methods - NCBI Bookshelf - NIH
In most patients with lymphadenopathy, a diagnosis can be made after a careful history, physical examination, and appropriate testing including hematologic ...<|control11|><|separator|>
[63]
Lymphadenitis Workup - Medscape Reference
Apr 4, 2024 · Ultrasonography may be useful for verifying lymph node involvement and taking accurate measurements of enlarged nodes.
[64]
Diagnostic challenges in cervical tuberculous lymphadenitis: A review
Chest X-ray, neck ultrasound (USG), computerized tomography (CT) and magnetic resonance imaging (MRI) of neck can be performed in cervical lymphadenopathies.
[65]
Lymphadenitis | Infectious Diseases Management Program at UCSF
Lymphadenitis - acute, suppurative bacterial, usually unilateral. Usual presentation, without suspected dental source (e.g. periodontal disease, poor dental ...
[66]
Acute bacterial lymphadenitis in children: a retrospective, cross ...
Mar 7, 2023 · Uncomplicated lymphadenitis can be managed with narrow-spectrum beta-lactam therapy (such as flucloxacillin) with low rates of relapse or complications.
[67]
Practice Essentials, Pathophysiology of Scrofula, Epidemiology of ...
Aug 17, 2023 · Antibiotic regimens effective for pulmonary infection can be applied to tuberculous lymphadenitis. The most common regimen consists of a four- ...
[68]
Herpes Simplex Virus Lymphadenitis: Case Report and Review of ...
Acyclovir (10 mg/kg iv q8h) was initiated in early August 1996. Within 2 days, the patient defervesced and had diminished erythema and tenderness of the neck ...
[69]
Liposomal amphotericin B (AmBisome) for fungal infections in ...
AmBisome represents a major breakthrough in the treatment of invasive fungal infections, especially in immunocompromised patients.
[70]
Pediatric Acute Suppurative Cervical Lymphadenitis: A Condition ...
May 9, 2025 · He was given IV clindamycin, and an otolaryngologist performed incision and drainage the next day. A Penrose drain was placed, and the patient ...
[71]
Suppurative cervical lymphadenitis in adult: An analysis of ...
Aspiration or surgical drainage can be effective in certain patients. Pathogen isolation and tissue biopsy should be performed to ensure accurate diagnosis and ...
[72]
Treatment | Sjögren's Foundation
Corticosteroids, a class of drugs that includes prednisone, are fast-acting and may be highly successful in halting severe symptoms of Sjögren's and/or a flare.
[73]
Chemotherapy for Non-Hodgkin Lymphoma
Feb 15, 2024 · Chemo is the main treatment for most people with non-Hodgkin lymphoma (NHL). It may be used alone or combined with other treatments.
[74]
Lymphadenopathy and Lymphadenitis | Johns Hopkins ABX Guide
Mar 17, 2024 · For children (especially ages 4-8 yrs), cervical LN is > 90% of presentations, with viral explanations most common, followed by aerobic/ ...
[75]
Lymphadenopathies: A Retrospective Study of Epidemiology ...
Jan 30, 2025 · With a prevalence of 57.3%, the cervical region lymph nodes are the most commonly affected location. The three most commonly observed LAP ...
[76]
Cervical lymph nodes in rheumatology: A diagnostic dilemma
The most compromised groups are cervical (43%), mesenteric (21%), axillary (18%) and inguinal (17%). Cervical lymphadenopathy is the first clinical ...
[77]
IgG4-Related Lymphadenopathy - PMC - NIH
Jun 10, 2012 · The diagnosis of IgG4-related lymphadenopathy is complicated owing to a great histological diversity, with at least 5 histological subtypes.Missing: etiology | Show results with:etiology
[78]
Paraneoplastic Syndromes - StatPearls - NCBI Bookshelf - NIH
Paraneoplastic syndromes are rare disorders with complex systemic clinical manifestations from an occult malignancy causing an altered immune system.