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Streptococcus

Streptococcus is a genus of Gram-positive bacteria characterized by spherical cocci that typically occur in pairs (diplococci) or chains, are nonmotile and non-sporeforming, and are generally catalase-negative facultative anaerobes.^[1] The name derives from the Greek words streptos (chain) and kokkos (berry), reflecting their chained arrangement under the microscope, and was coined by Austrian surgeon Theodor Billroth in 1874 to describe organisms observed in wound infections and erysipelas.^[2] These bacteria require enriched media for growth, such as blood agar, where they exhibit distinct hemolytic patterns—beta-hemolysis (complete clearing), alpha-hemolysis (partial greening), or gamma-hemolysis (none)—and some species produce capsules, notably hyaluronic acid in Group A streptococci.^[1] The genus encompasses over 50 species and several subspecies, classified primarily into Lancefield groups (A through V) based on cell wall carbohydrate antigens, though not all species fit this scheme.^[3] Notable species include Streptococcus pyogenes (Group A), S. agalactiae (Group B), S. pneumoniae (pneumococcus), and various viridans group streptococci, with some like enterococci formerly included but now reclassified.^[1] Streptococci inhabit diverse niches as commensal organisms in the human and animal microbiota, colonizing sites such as the nasopharynx, oral cavity, skin, and gastrointestinal tract, while certain species are exclusively human pathogens or zoonotic agents.^[1] For instance, oral streptococci like S. mutans are early colonizers of the mouth acquired post-birth, contributing to the normal flora but also implicated in dental caries through biofilm formation.^[4] Medically, Streptococcus species are of profound importance due to their role in a spectrum of infections ranging from mild to life-threatening, with approximately 35 species capable of causing invasive human disease.^[3] S. pyogenes is a leading cause of bacterial pharyngitis (strep throat), scarlet fever, skin infections like impetigo and necrotizing fasciitis, and severe conditions such as streptococcal toxic shock syndrome, resulting in over 500,000 deaths annually worldwide; recent surveillance data indicate a significant increase in invasive infections, with incidence more than doubling in the United States from 2013 to 2022 and reaching a 20-year high in 2023 (as of 2024).^[3]^[5] S. pneumoniae primarily causes pneumonia, meningitis, and otitis media, accounting for approximately 300,000 deaths in children under five each year (as of 2024), while S. agalactiae is a major neonatal pathogen leading to sepsis and meningitis.^[3]^[6] Virulence is driven by factors including polysaccharide capsules for immune evasion, hemolysins like streptolysin O, M proteins for antiphagocytic activity, and enzymes such as streptokinase.^[1] Beyond pathology, streptococci contribute to post-infectious immune-mediated diseases like rheumatic fever and glomerulonephritis, and some species serve industrial roles in dairy fermentation (e.g., cheese and yogurt production) and as indicators of fecal pollution in water.^[1]

Introduction and History

Definition and Significance

Streptococcus is a genus of Gram-positive bacteria consisting of spherical cells, or cocci, that typically arrange in pairs or chains and are facultatively anaerobic, belonging to the phylum Bacillota.^[1]^[7] These nonmotile, nonsporeforming microbes are catalase-negative and often identified initially by their hemolytic patterns on blood agar, such as alpha- or beta-hemolysis.^[1] Approximately 126 species are currently recognized within the genus as of 2024, encompassing a diverse range of commensal, opportunistic, and pathogenic organisms.^[8] Medically, Streptococcus holds significant importance due to its role in human infections, with many species acting as opportunistic pathogens that cause substantial morbidity and mortality.^[9] Key examples include S. pyogenes (group A Streptococcus), which leads to pharyngitis, skin infections, and severe invasive diseases like necrotizing fasciitis, and S. pneumoniae, a primary cause of pneumonia and meningitis.^[10] Globally, group A streptococcal diseases alone result in over 500,000 deaths annually, including from acute infections and long-term sequelae such as rheumatic heart disease.^[10] The burden is particularly acute in low-resource settings, where approximately 616 million cases of strep throat occur each year, contributing to over 300,000 deaths from invasive infections as of recent estimates.^[11]^[12] Beyond pathology, Streptococcus species contribute positively to ecology and industry; they form a dominant component of the human oral microbiome, aiding in biofilm formation and carbohydrate metabolism.^[13] Certain strains, such as S. thermophilus, are essential in food fermentation processes, including yogurt and cheese production, enhancing flavor and texture through lactic acid generation.^[14] Economically, streptococcal infections impose a heavy toll, with U.S. healthcare and productivity costs for group A Streptococcus exceeding $5 billion annually, underscoring the need for improved prevention and treatment strategies.^[15]

Discovery and Historical Milestones

The genus Streptococcus was first described in 1874 by Austrian surgeon Theodor Billroth, who observed chain-forming bacteria in pus from wound infections and erysipelas cases during his studies at the Vienna General Hospital.^[16] Billroth's microscopic observations marked the initial recognition of these organisms as distinct pathogens associated with surgical infections, though he did not formally name the genus at that time.^[2] In 1884, German physician Friedrich Julius Rosenbach refined the nomenclature by naming Streptococcus pyogenes based on isolates from purulent wounds, emphasizing the pus-forming (pyogenes) nature of the chain-like (streptos) bacteria.^[17] Concurrently, in the 1880s, Louis Pasteur and George Sternberg independently identified Streptococcus pneumoniae as the causative agent of pneumonia through experiments involving saliva injections in rabbits, establishing its role in respiratory infections.^[18] These early isolations shifted perceptions from vague "pus organisms" to specific streptococcal species linked to human disease. A pivotal advancement came in 1933 when Rebecca C. Lancefield introduced serological grouping based on cell wall carbohydrate antigens, classifying hemolytic streptococci into groups (e.g., A for S. pyogenes) to differentiate human pathogens from animal-associated strains.^[19] This system, expanded in 1935, enabled precise epidemiological tracking and remains foundational for identifying virulence potential. The 20th century saw further evolution from viewing streptococci as a uniform group to recognizing a diverse genus, exemplified by Alexander Fleming's 1928 discovery of penicillin, which produced a substance inhibiting streptococcal growth and revolutionized treatment of infections like scarlet fever and puerperal sepsis by the 1940s.^[20] In 2018, a comprehensive phylogenetic re-analysis of 70 Streptococcus genomes delineated 14 distinct subclades, incorporating four established species groups and six novel ones, providing a genomic framework that refined historical classifications and highlighted evolutionary diversity.^[21] Recent taxonomic updates as of 2025 have added four novel species from the human oral cavity, further expanding the genus.^[22]

Taxonomy and Classification

Traditional Phenotypic Classification

The traditional phenotypic classification of Streptococcus species relies on observable characteristics such as hemolytic reactions on blood agar, serological grouping based on cell wall antigens, and biochemical tests, which were foundational before molecular methods emerged. This system, developed in the early 20th century, categorizes streptococci primarily into hemolytic groups and serological groups to aid in identification and differentiation, particularly for clinically relevant pathogens.^[1] Hemolytic classification, introduced by Schottmüller in 1903, distinguishes streptococci based on their effects on red blood cells in sheep blood agar plates. Alpha-hemolytic streptococci produce partial hemolysis, resulting in a greenish discoloration around colonies due to the production of hydrogen peroxide and reduced hemoglobin. Beta-hemolytic streptococci cause complete hemolysis, forming clear zones around colonies from the action of hemolysins like streptolysin O and S. Gamma-hemolytic (or non-hemolytic) streptococci show no hemolysis, appearing as opaque colonies without zones. This differentiation is not always reliable, as hemolytic patterns can vary with media composition, incubation conditions, or strain differences.^[23]^[1] The Lancefield serological grouping system, established by Rebecca Lancefield in 1933, further refines classification by detecting specific carbohydrate antigens in the bacterial cell wall using antisera. Groups are designated A through H (and beyond to V for some species), with group A streptococci featuring a polyrhamnose backbone with N-acetylglucosamine side chains, and group B identified by glucosyl-rhamnose polymers. For instance, most beta-hemolytic streptococci fall into groups A (e.g., S. pyogenes), B (S. agalactiae), C, or G, while group D includes strains that hydrolyze esculin. This method involves extracting the antigen via acid or enzyme treatment and precipitating it with group-specific antibodies, enabling rapid serological identification.^[24]^[25]^[19] Additional phenotypic traits commonly used in classification include consistent biochemical properties shared across streptococci. All species are catalase-negative, distinguishing them from staphylococci, and most are facultative anaerobes capable of growth in both aerobic and anaerobic conditions, though some like S. mutans prefer microaerophilic environments. Fermentation patterns also aid grouping; for example, group D streptococci ferment lactose and mannitol, while group A does not ferment sorbitol. These traits, assessed via tests like bile-esculin hydrolysis or sugar fermentation broths, complement hemolysis and serology for preliminary identification.^[1]^[23] Despite its utility, the traditional phenotypic system has notable limitations, including phenotypic overlap and potential misclassification. For instance, enterococci were initially classified as group D streptococci due to shared fermentation traits but were reclassified into a separate genus in the 1980s based on genetic differences, highlighting the system's inability to resolve evolutionary relationships. Variability in antigen expression and cross-reactivity in serological tests can lead to errors, particularly for non-beta-hemolytic strains, prompting the adoption of phylogenetic methods for more precise taxonomy.^[23]^[25]

Modern Phylogenetic Classification

The modern phylogenetic classification of Streptococcus relies primarily on molecular techniques such as 16S rRNA gene sequencing and multi-locus sequence typing (MLST), which enable precise delineation of evolutionary relationships by analyzing conserved ribosomal RNA genes and multiple housekeeping loci, respectively.^[26]^[27] These methods have revealed a diverse genus encompassing 139 validly published species as of November 2025, reflecting ongoing genomic discoveries and taxonomic refinements.^[8]^[28] A pivotal 2018 phylogenomic study utilizing core genome sequences from 70 Streptococcus type strains robustly demarcated the genus into 14 distinct species groups, providing a genome-based framework that surpasses earlier phenotypic groupings in resolution and stability.^[21]^[29] These groups include the well-established pyogenic (e.g., S. pyogenes), bovis (S. gallolyticus), mutans (S. mutans), salivarius (S. salivarius), and anginosus (S. anginosus) clades, alongside nine additional subclades that highlight finer evolutionary divergences within the genus.^[21] This core genome approach, focusing on shared orthologous genes, has informed subsequent classifications by emphasizing genetic cohesion over traditional hemolysis patterns. Recent genomic surveys have expanded the genus with novel species, such as S. wuxiensis, S. jiangnanensis, and S. fermentans, all isolated from human breast milk in 2025 and positioned within the salivarius group via 16S rRNA and whole-genome analyses.^[30] Similarly, S. shenyangsis, described in 2021 from the oropharynx of a healthy child, clusters closely with the mitis group based on MLST and 16S rRNA phylogenies, underscoring the genus's association with human mucosal niches.^[31] Significant reclassifications have shaped the genus's boundaries; notably, in 1984, genomic DNA hybridization studies led to the separation of Enterococcus (e.g., E. faecalis) from Streptococcus due to distinct phylogenetic positions and phenotypic traits like growth in high-salt environments.^[32] Ongoing debates persist regarding S. suis, a porcine pathogen with zoonotic potential, as phylogenomic analyses reveal divergent clades that challenge its monophyletic placement, with some strains showing closer affinity to related species like S. parasuis based on average nucleotide identity thresholds below 95%.^[33]^[34] These discussions highlight the need for integrated multi-omic approaches to resolve ambiguous boundaries within the genus.

Biology and Physiology

Cellular Structure and Morphology

Streptococci are Gram-positive cocci measuring 0.5 to 2.0 μm in diameter, typically appearing spherical or ovoid and arranged in pairs (diplococci) or chains due to division in a single plane.^[1]^[35] These non-motile bacteria possess a thick cell wall that retains the crystal violet stain during Gram staining, distinguishing them from Gram-negative organisms.^[1] Species such as Streptococcus pyogenes are round-to-ovoid with diameters of 0.6-1.0 μm, while Streptococcus pneumoniae often exhibits a lancet-shaped diplococcal form measuring 0.5-1.25 μm.^[1] The cell wall of streptococci consists primarily of a thick peptidoglycan layer composed of repeating units of N-acetylglucosamine and N-acetylmuramic acid, cross-linked by peptide bridges to provide structural rigidity.^[1] Embedded within this layer are wall teichoic acids, which are anionic polymers covalently linked to the peptidoglycan via phosphodiester bonds to muramic acid residues, and lipoteichoic acids, which anchor to the cytoplasmic membrane and extend into the wall to link proteins.^[36] Many pathogenic species, such as S. pneumoniae, produce a polysaccharide capsule surrounding the cell wall; this capsule comprises over 100 serotypes of repeating saccharide units attached to the peptidoglycan (as of 2025).^[36]^[37] In S. pyogenes, the capsule is composed of hyaluronic acid, a non-antigenic polymer that contributes to the smooth colonial morphology.^[1]^[35] Internally, streptococci lack spores and contain a single circular chromosome that encodes essential genetic information, with some strains harboring plasmids that confer antibiotic resistance.^[1] Variations in morphology can occur; for instance, older cultures may show pleomorphism or loss of Gram positivity, and S. pneumoniae can form short chains in certain growth conditions, with colonies displaying central depressions due to autolysis.^[1] Electron microscopy reveals the cell wall as a 30-40 nm electron-dense band with a surrounding low-density layer of 60-80 nm in S. pneumoniae.^[36]

Growth Requirements and Metabolism

Streptococci are facultative anaerobes capable of growth in the presence or absence of oxygen, though most species exhibit aerotolerance rather than strict aerophily. Optimal growth occurs at temperatures between 35°C and 37°C, reflecting their adaptation to human body temperature, with incubation periods typically requiring 18 to 24 hours for visible colony formation on solid media. The preferred pH range is neutral to slightly alkaline, around 7.0 to 7.5, as seen in standard blood agar formulations where deviations can inhibit hemolytic reactions and overall proliferation. Due to their fastidious nature, streptococci necessitate enriched media such as tryptic soy agar supplemented with 5% sheep blood or Todd-Hewitt broth with yeast extract, which provide essential peptides and complex nutrients absent in minimal media.^[1]^[38]^[39]^[40] Metabolically, streptococci rely on fermentative pathways for energy production, predominantly through homolactic fermentation where glucose is converted to lactic acid via the Embden-Meyerhof-Parnas (glycolytic) pathway, yielding two molecules of ATP per glucose molecule through substrate-level phosphorylation. This process involves phosphoenolpyruvate-dependent phosphotransferase systems (PTS) for sugar uptake and phosphorylation, enabling efficient carbohydrate utilization in nutrient-variable environments. While most species, such as Streptococcus pyogenes and Streptococcus pneumoniae, are homolactic under anaerobic or low-oxygen conditions, some exhibit mixed-acid fermentation (producing acetate, formate, and ethanol alongside lactate) when exposed to higher oxygen levels, reflecting metabolic flexibility. Heterofermentative metabolism, involving the production of additional byproducts like CO₂, is less common but observed in certain oral species. Streptococci lack complete respiratory chains and cytochromes, precluding aerobic respiration unless exogenous heme is supplied.^[41]^[42]^[41] Nutritionally, streptococci are auxotrophic for numerous amino acids—often up to 15 or more, including glutamine and cystine—and require exogenous sources of vitamins such as NAD, which they salvage via salvage pathways rather than de novo synthesis. They are incapable of heme biosynthesis, relying on host-derived factors for any limited respiratory capabilities in supplemented conditions, and depend on oligopeptide permeases for peptide uptake to meet protein synthesis demands. This fastidiousness underscores their adaptation to nutrient-rich host niches, where complex media mimicking blood or tissue fluids support robust growth. Regarding oxygen sensitivity, while aerotolerant due to enzymes like superoxide dismutase and NADH oxidases, prolonged exposure to high oxygen levels can generate reactive oxygen species that impair viability; capnophilic species like S. pneumoniae show enhanced growth under 5% to 10% CO₂ atmospheres, which stabilizes pH and facilitates proliferation.^[41]^[38]^[42]

Ecology

Natural Habitats and Reservoirs

Streptococcus species are predominantly host-associated bacteria, primarily colonizing mucosal surfaces in humans and animals, though certain species occupy environmental niches such as dairy products, soil, and water. The genus encompasses over 50 species adapted to diverse ecological roles, with most thriving in warm, nutrient-rich environments provided by animal hosts. These bacteria often form biofilms, such as in oral plaque, which enhances their persistence in natural settings.^[43]^[44]^[45] In humans, the oropharynx is a primary reservoir for the viridans group streptococci, which constitute a significant portion of the normal oral microbiota, with prevalence rates often exceeding 70% in healthy adults and approaching 98% in children. The skin and genital tract also serve as reservoirs, particularly for group B Streptococcus (Streptococcus agalactiae), which colonizes the vaginal mucosa in 10-30% of non-pregnant women and higher rates during pregnancy. These human mucosal sites support asymptomatic carriage, underscoring the commensal nature of many Streptococcus species.^[46]^[47]^[48] Animal reservoirs are equally diverse, with Streptococcus suis predominantly inhabiting the nasopharynx and saliva of pigs, where it persists as a commensal in up to 100% of healthy swine herds. Streptococcus agalactiae is a common resident in the udders of cattle, causing bovine mastitis and serving as a reservoir linked to dairy environments. In wildlife, species such as Streptococcus catagoni have been isolated from the respiratory tracts of Chacoan peccaries (Catagonus wagneri), highlighting the genus's adaptation to non-domesticated mammals. Other examples include streptococci in marine mammals and fish, where aquatic environments may act as secondary reservoirs.^[49]^[50]^[51] Certain Streptococcus species extend beyond host associations into environmental habitats; for instance, Streptococcus thermophilus is naturally found in raw milk and persists in dairy processing environments, contributing to fermented products like yogurt. Fecal streptococci, including some group D species, survive in soil and water under moist conditions for weeks, indicating limited environmental persistence influenced by temperature and humidity. These non-host niches, while not primary, facilitate occasional transmission between reservoirs.^[52]^[53]

Commensal and Pathogenic Interactions

Streptococcus species often exist as commensals within host microbiomes, contributing to microbial balance and providing protective functions against pathogens. Viridans group streptococci, primary colonizers of the oral cavity, produce bacteriocins and other antimicrobial substances that inhibit the growth of harmful bacteria such as Streptococcus mutans and Porphyromonas gingivalis, thereby preventing dental caries and periodontal disease.^[54]^[55] In the oral flora, these streptococci facilitate early biofilm formation that excludes pathogens through competitive adhesion and metabolic byproducts. Certain Streptococcus species, such as Streptococcus thermophilus, also support digestive processes in the gut microbiome by aiding in the breakdown of complex carbohydrates and lactose fermentation, promoting nutrient absorption and maintaining intestinal homeostasis.^[56]^[57] However, under certain conditions, commensal Streptococcus can shift to opportunistic pathogens, particularly when the host microbiota is disrupted. Antibiotic treatment reduces microbial diversity, allowing overgrowth of Streptococcus species like Group B Streptococcus agalactiae in the gut, which can lead to invasive infections by outcompeting beneficial bacteria. Biofilm formation by streptococci further enhances this opportunism, enabling communities to evade host immune responses through reduced phagocytosis and complement activation, as seen in respiratory tract biofilms of Streptococcus pneumoniae.^[48]^[58] Host factors significantly influence the transition from commensalism to pathogenesis in Streptococcus interactions. Immunocompromised states, including those from chronic diseases or immunosuppressive therapies, heighten susceptibility to streptococcal overgrowth and infection by impairing mucosal barriers and innate immunity. In the elderly, age-related immunosenescence exacerbates this risk, with higher incidence of pneumococcal pneumonia due to diminished T-cell responses and reduced mucociliary clearance in the respiratory tract.^[59]^[60] Ecological dynamics within microbiomes underscore the competitive nature of Streptococcus with other bacteria, shaping community stability. Streptococci engage in resource competition and produce natural products like antimicrobial peptides to suppress rivals such as Veillonella species in oral biofilms, maintaining ecological equilibrium. Recent 2025 research highlights how enrichment of Streptococcus oralis in respiratory dysbiosis boosts innate immunity via cytokine modulation, potentially protecting against viral infections like influenza by altering microbial competition.^[61]

Key Species

Streptococcus pyogenes (Group A)

Streptococcus pyogenes, commonly referred to as Group A Streptococcus (GAS), is a gram-positive, beta-hemolytic coccus that grows in chains or pairs and is classified in Lancefield Group A based on its specific cell wall carbohydrate antigen.^[62] This bacterium exhibits complete hemolysis on blood agar, producing clear zones around colonies due to the action of oxygen-labile streptolysin O and oxygen-stable streptolysin S.^[62] A hallmark virulence factor is the M protein, a coiled-coil surface protein that inhibits phagocytosis by binding to host complement regulators and mimicking human proteins, thereby evading innate immune responses.^[63] Over 220 emm types have been identified through sequencing of the emm gene, which encodes the hypervariable N-terminal region of the M protein; these types vary in geographic distribution and are associated with different disease severities, with emm1 and emm3 often linked to invasive infections.^[64] Epidemiologically, S. pyogenes maintains asymptomatic pharyngeal carriage in 5-15% of the general population, with higher rates among children aged 5-15 years in crowded or low-socioeconomic settings, serving as a reservoir for transmission.^[62] Following the COVID-19 pandemic, global surveillance has documented an uptick in invasive GAS diseases since 2020, with notable surges in cases and severity reported in Europe, the United States, and Asia, potentially influenced by reduced population immunity during lockdowns.^[5] A 2025 study from Osaka University identified a novel mutation in the fhuB gene of emm89 strains, which disrupts iron uptake and is associated with enhanced virulence in severe invasive infections, particularly in Japanese isolates; this genetic variation, absent in non-severe strains, highlights evolving pathogenicity.^[65] Unique to S. pyogenes are its secreted toxins, including streptolysins O and S, which lyse host cells and erythrocytes to promote tissue invasion and immune evasion, and multiple DNases (e.g., streptodornase A-F) that hydrolyze neutrophil extracellular traps to facilitate bacterial dissemination.^[66] These factors contribute to its capacity to cause necrotizing fasciitis, a rapidly progressive soft tissue infection characterized by toxin-mediated necrosis and systemic toxicity.^[67] Vaccine development efforts advanced in 2025 with preclinical evaluation of an mRNA-lipid nanoparticle platform encoding five conserved antigens—streptococcal C5a peptidase, streptolysin O, SpyCEP, arginine deiminase, and trigger factor—demonstrating robust immunogenicity and protection in murine and primate models against diverse GAS strains.^[68] Although primarily a human pathogen with no established animal reservoirs, rare isolations from animals such as rabbits and sheep suggest occasional zoonotic transmission from human carriers.^[69]

Streptococcus agalactiae (Group B)

Streptococcus agalactiae, commonly known as group B Streptococcus (GBS), is a beta-hemolytic gram-positive bacterium characterized by its Lancefield group B carbohydrate antigen, a peptidoglycan-anchored structure that distinguishes it from other streptococci.^[70] This species produces a polysaccharide capsule that enables classification into 10 serotypes (Ia, Ib, II–IX) based on structural variations in the capsular polysaccharides, which play a key role in immune evasion and pathogenesis.^[71] Additionally, S. agalactiae expresses surface proteins, including members of the Ibc family (such as the Alpha C protein), which contribute to adherence and host interaction.^[72] As a member of the beta-hemolytic streptococci, it exhibits complete hemolysis on blood agar, often enhanced by synergistic effects with other hemolysins.^[72] Epidemiologically, S. agalactiae colonizes the vaginal and rectal mucosa of 10–30% of pregnant women asymptomatically, serving as the primary reservoir for vertical transmission to newborns.^[73] This carriage rate facilitates its role as the leading cause of early-onset neonatal sepsis and meningitis, with a global incidence of invasive disease estimated at 0.49 cases per 1,000 live births.^[74] In neonatal contexts, transmission typically occurs during labor, underscoring the bacterium's significance in perinatal infections.^[75] A distinctive feature of S. agalactiae is the CAMP factor, a pore-forming cytolytic protein that enhances hemolysis through synergistic activity with sphingomyelinase C from Staphylococcus aureus, producing a characteristic arrowhead pattern on blood agar.^[76] Regarding vaccine development, progress in 2025 includes ongoing Phase II trials of a 6-valent glycoconjugate vaccine (GBS6) targeting major capsular polysaccharide serotypes (Ia, Ib, II, III, IV, V) for administration to pregnant women, aiming to induce protective transplacental antibodies against neonatal disease.^[77] Preclinical studies have demonstrated robust serotype-specific IgG responses with this approach.^[78] In veterinary medicine, S. agalactiae is a primary etiological agent of bovine mastitis, causing significant economic losses in dairy herds through intramammary infections that lead to reduced milk production and quality.^[79] Evidence suggests zoonotic potential, with genomic analyses indicating shared isolates between human and bovine strains, raising concerns for interspecies transmission.^[80]

Streptococcus pneumoniae

Streptococcus pneumoniae is a Gram-positive, alpha-hemolytic bacterium characterized by its lancet-shaped diplococci morphology, often appearing in pairs under microscopic examination.^[81]^[82] This encapsulated pathogen is facultatively anaerobic and a major cause of respiratory infections, with its polysaccharide capsule playing a key role in evading host immunity.^[83] The species exhibits over 100 distinct capsular serotypes, which vary in virulence and prevalence; the 23-valent pneumococcal polysaccharide vaccine (PPSV23) targets 23 of these serotypes to provide protection against invasive disease.^[84]^[85] Epidemiologically, S. pneumoniae colonizes the nasopharynx asymptomatically in approximately 5-10% of healthy adults, serving as a reservoir for transmission, though carriage rates are higher in children.^[86] Globally, it contributes to about 1.6 million deaths annually, predominantly from pneumonia, with higher burdens in low-resource settings.^[87] A 2024 genomic study in South Africa revealed slow geographical migration dynamics of pneumococcal strains, taking up to 50 years for homogeneous mixing across regions due to focal transmission patterns influenced by human mobility.^[88] This highlights the pathogen's evolutionary adaptation and the challenges in controlling its spread through vaccination alone. Distinctive features of S. pneumoniae include the Quellung reaction, a serological method using type-specific antisera to visualize capsule swelling under microscopy, which remains the gold standard for serotype identification.^[89] Additionally, the major autolysin LytA facilitates natural competence for genetic transformation by promoting cell lysis and DNA release during the competent state, aiding in horizontal gene transfer and antibiotic resistance evolution.^[90] Vaccination with conjugate vaccines like PCV13 and PCV21 has dramatically reduced invasive pneumococcal disease by approximately 70% in vaccinated populations, particularly through herd immunity effects.^[84] However, post-vaccination serotype replacement has occurred, with non-vaccine serotypes such as 6C, 12F, and 23B emerging and increasing in carriage and disease incidence.00588-7/fulltext)

Other Notable Species

The viridans group streptococci, comprising alpha-hemolytic species such as Streptococcus mutans and Streptococcus sanguinis, are primarily commensal inhabitants of the human oral cavity, where they contribute to the normal microbiota but can become opportunistic pathogens.^[4] These bacteria are notable for their role in infective endocarditis, particularly in patients with underlying heart conditions, as they can enter the bloodstream during dental procedures and adhere to damaged heart valves.^[91] S. mutans, in particular, is a key etiological agent in dental caries, producing acids that demineralize tooth enamel through fermentation of dietary carbohydrates.^[4] Formerly classified as Group D streptococci, species like Streptococcus bovis (now reclassified as Streptococcus gallolyticus subsp. gallolyticus) were historically grouped with enterococci but are now recognized as distinct within the Streptococcus genus.^[92] This species is associated with bacteremia that signals underlying colorectal neoplasia, with studies showing that up to 60% of patients with S. gallolyticus infections harbor colonic tumors, prompting routine colonoscopy screening.^[93] Among emerging zoonotic species, Streptococcus suis stands out as a major veterinary pathogen causing meningitis, septicemia, and arthritis in pigs, with sporadic human infections reported predominantly in Southeast Asia among those handling raw pork.^[94] Human cases often manifest as severe meningitis with hearing loss, and outbreaks have been documented in Vietnam and China, highlighting occupational risks in the swine industry.^[95] In 2025, novel species such as Streptococcus wuxiensis were isolated from human breast milk, demonstrating potential as commensals that utilize human milk oligosaccharides to support infant gut microbiota development.^[30] These findings suggest probiotic-like roles in modulating early-life microbial ecosystems, though further research is needed to confirm non-pathogenic status.^[96] Veterinarily significant species include Streptococcus equi subsp. equi, the causative agent of strangles in horses, a highly contagious upper respiratory infection characterized by lymph node abscessation and fever.^[97] This disease affects Equidae worldwide, with vaccination and biosecurity measures essential for control.^[98] Beyond these, the Streptococcus genus encompasses approximately 20 additional non-pyogenic, non-bovis species, many of which are commensal or host-specific with limited pathogenic potential in humans.^[23]

Pathogenesis

Virulence Factors

Streptococcus species employ a diverse array of virulence factors that enable adhesion to host tissues, toxin-mediated damage, immune evasion, and enzymatic facilitation of dissemination. These factors are predominantly surface-associated or secreted proteins and polysaccharides, contributing to the pathogen's ability to colonize and persist within the host.^[99] Adhesins in Streptococcus promote initial attachment to mucosal surfaces and extracellular matrix components. The M protein, a coiled-coil surface fibrillar protein primarily in Streptococcus pyogenes (Group A Streptococcus), binds to host receptors such as CD46 on keratinocytes and fibrinogen, facilitating bacterial adherence and inhibiting opsonization.^[100] Pili, long filamentous structures encoded by distinct genetic islands, mediate tight adhesion to host epithelial cells and collagen; for instance, in S. pyogenes and S. agalactiae, they enhance colonization of pharyngeal and vaginal mucosa, respectively.^[101] Toxins produced by Streptococcus directly damage host cells and modulate immune responses. Streptolysin O and S are pore-forming cytolysins that disrupt plasma membranes of erythrocytes, leukocytes, and endothelial cells; streptolysin O, a cholesterol-dependent toxin, also suppresses neutrophil chemotaxis and promotes inflammasome activation.^[99] Superantigens, such as the streptococcal pyrogenic exotoxins (SPEs) including SpeA and SpeC in S. pyogenes, bind T-cell receptors outside the antigen-binding groove, causing massive cytokine release and systemic inflammation.^[102] Immune evasion strategies in Streptococcus counteract phagocytosis and antibody-mediated clearance. Polysaccharide capsules, composed of hyaluronic acid in S. pyogenes or phosphorylcholine in S. pneumoniae, form a protective barrier that inhibits complement deposition and phagocyte recognition, significantly enhancing survival in blood. Proteinases like IdeS (immunoglobulin G-degrading enzyme of S. pyogenes) specifically cleave the hinge region of human IgG, generating Fab and Fc fragments that impair opsonization and antibody-dependent cellular cytotoxicity.^[103] Hyaluronidase enzymes degrade host hyaluronic acid in connective tissues, creating pathways for bacterial dissemination while also mimicking host structures to evade detection.^[66] Enzymes secreted by Streptococcus further support virulence by degrading host defenses and promoting spread. Deoxyribonucleases (DNases), such as Sda1 in S. pyogenes, hydrolyze DNA in neutrophil extracellular traps (NETs), preventing entrapment and killing of bacteria during phagocytosis. Streptokinase activates host plasminogen to plasmin, which dissolves fibrin clots and degrades extracellular matrix, thereby facilitating bacterial invasion from localized sites.

Infection Mechanisms

Streptococci initiate infection through colonization of host mucosal surfaces, primarily via adherence mechanisms mediated by surface structures such as pili and teichoic acids. In species like Streptococcus pyogenes and S. agalactiae, pili facilitate attachment to epithelial cells by interacting with host extracellular matrix components, enabling initial binding and subsequent biofilm formation that protects the bacteria from host defenses and antibiotics.^[104] Lipoteichoic acids on the cell wall further promote adherence to fibronectin and other host proteins, enhancing stable colonization in areas like the throat or genital tract.^[105] Biofilm development, influenced by teichoic acid modifications, allows streptococci to form structured communities that resist shear forces and immune clearance, as observed in S. mutans dental plaques and S. agalactiae vaginal persistence.^[106]^[107] Once colonized, streptococci invade deeper tissues using enzymes and protective structures to breach barriers and enter the bloodstream. Hyaluronidase, produced by S. pyogenes and S. agalactiae, depolymerizes hyaluronic acid in the extracellular matrix, facilitating tissue penetration and promoting ascending infections, such as in group B streptococcal preterm labor models where it impairs neutrophil function and enhances bacterial spread.^[108]^[109] The capsular polysaccharide (CPS) shields bacteria from phagocytosis, aiding survival during mucosal breaches that lead to bacteremia, particularly in S. pneumoniae where CPS variants correlate with invasive disease progression.^[110]^[111] This invasion process often transitions from localized infection to systemic dissemination via damaged endothelium. Streptococci modulate the host immune response to evade clearance and exacerbate pathology, notably through superantigens that trigger massive T-cell activation and cytokine storms. In S. pyogenes, superantigens like streptococcal pyrogenic exotoxin A (SPE-A) cross-link MHC class II and T-cell receptors, leading to polyclonal T-cell proliferation and release of pro-inflammatory cytokines such as TNF-α and IL-6, which contribute to toxic shock syndrome.^[112] Additionally, streptolysin O induces apoptosis in macrophages, suppressing phagocytic activity and allowing unchecked bacterial replication during invasive infections.^[113] These mechanisms collectively dampen adaptive immunity while amplifying innate inflammation, creating a favorable environment for pathogen persistence. Dissemination of streptococci occurs through fibrinolytic activity that dissolves clots and promotes vascular spread. Streptokinase activates host plasminogen to plasmin, enabling S. pyogenes to degrade fibrin barriers and escape immune-trapping clots, as demonstrated in models where bacteria remain viable within clots before utilizing plasminogen for fibrinolysis and deeper tissue invasion.^[114]^[115] This process facilitates hematogenous spread to distant sites, such as in necrotizing fasciitis. Recent genetic analyses in 2025 identified mutations in emm89 S. pyogenes strains that enhance invasiveness by altering regulatory pathways, contributing to increased invasive disease incidence post-pandemic.^[116]

Diseases Caused

Suppurative Infections

Suppurative infections caused by Streptococcus species involve direct bacterial invasion of tissues, leading to acute inflammation and pus formation. These infections primarily affect the throat, skin, soft tissues, and systemic sites, with Streptococcus pyogenes (group A Streptococcus, or GAS) being the most common culprit in non-invasive and invasive cases among children and adults. Other species, such as Streptococcus agalactiae (group B Streptococcus, or GBS) and Streptococcus pneumoniae, contribute to specific invasive syndromes. Clinical presentation often includes localized pain, fever, and erythema, progressing to abscesses or deeper tissue destruction if untreated.^[62] Pharyngitis, or strep throat, is a hallmark suppurative infection caused by S. pyogenes, accounting for 15-30% of cases in children and 5-20% in adults. It manifests as sudden-onset sore throat, fever, pharyngeal exudate, and tender cervical lymphadenopathy, typically resolving within days but risking spread to deeper sites. A toxin-mediated complication is scarlet fever, where S. pyogenes strains producing erythrogenic toxins (superantigens SpeA, SpeC, or SpeJ) induce a characteristic "sandpaper" rash, strawberry tongue, and circumoral pallor following pharyngitis. This rash results from toxin-induced capillary dilation and inflammation, affecting the skin and mucous membranes.^[117]^[118]^[119] Skin and soft tissue infections by GAS range from superficial to life-threatening. Impetigo presents as honey-crusted lesions on exposed skin, often in children, with bullous forms linked to exfoliative toxins. Cellulitis involves deeper dermal invasion, causing rapidly spreading erythema, warmth, and edema, commonly following minor trauma or insect bites. Necrotizing fasciitis, known as "flesh-eating disease," is a severe invasive form where GAS rapidly destroys subcutaneous tissues and fascia, leading to bullae, crepitus, and systemic toxicity; mortality rates range from 20% to 60%, depending on delays in surgical debridement and comorbidities.^[62]^[120]^[121]^[122] Invasive suppurative infections extend beyond local sites, causing bacteremia and organ involvement. GAS bacteremia often complicates skin or respiratory infections, leading to sepsis with high fever, hypotension, and multi-organ failure. GBS is a primary cause of puerperal sepsis in postpartum women, presenting as endometritis, bacteremia, or peritonitis following vaginal delivery, with rates of approximately 0.2–0.4 cases per 1,000 deliveries and associated maternal morbidity from uterine infection. S. pneumoniae induces lobar pneumonia, characterized by consolidation of an entire lung lobe on imaging, productive cough, rust-colored sputum, and pleuritic chest pain, predominantly in unvaccinated adults and children.^[62]^[123]^[124]^[125]^[126] Epidemiologically, GAS suppurative infections surged post-COVID-19 pandemic from 2022 onward into 2025, attributed to reduced population immunity from lockdowns and increased testing. In Europe and North America, invasive GAS cases rose 2- to 5-fold in children and adults, with pharyngitis and skin infections driving outpatient visits and necrotizing fasciitis hospitalizations increasing by up to 50% in some regions. This upsurge highlights vulnerabilities in pediatric and elderly populations, prompting enhanced surveillance.^[127]^[128]^[129]^[130]

Non-Suppurative Sequelae

Non-suppurative sequelae of streptococcal infections are delayed, immune-mediated complications that arise without ongoing bacterial replication, primarily following group A Streptococcus (GAS) pharyngitis or skin infections. These conditions result from aberrant immune responses, such as molecular mimicry or immune complex deposition, leading to inflammation in distant organs like the heart, kidneys, and brain.^[131] Acute rheumatic fever (ARF) is a classic non-suppurative sequela occurring 2-4 weeks after untreated GAS pharyngitis, with an estimated risk of 0.3-3% in susceptible individuals.^[132] The pathogenesis involves molecular mimicry, where antibodies against the GAS M protein cross-react with cardiac myosin in heart valves and myocardium, triggering autoimmune carditis and potential progression to rheumatic heart disease (RHD).^[133] Clinical manifestations include migratory polyarthritis, carditis, chorea, subcutaneous nodules, and erythema marginatum, with carditis being the most serious feature affecting up to 60% of cases.^[134] Post-streptococcal glomerulonephritis (PSGN) develops 1-3 weeks after GAS infection, often from pharyngitis or impetigo, due to deposition of immune complexes containing streptococcal antigens in the renal glomeruli.^[135] These complexes activate complement and inflammatory pathways, causing glomerular inflammation, hematuria, proteinuria, edema, and hypertension; nephritogenic strains like M types 49 and 12 are commonly implicated.^[136] Unlike ARF, PSGN can follow skin infections more frequently and is generally self-limiting in children but may lead to chronic kidney disease in some adults.^[137] Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) represent a controversial but recognized entity where GAS triggers sudden-onset obsessive-compulsive disorder (OCD), tics, anxiety, and emotional lability in genetically susceptible children aged 3-12 years.^[138] The mechanism likely involves autoantibodies crossing the blood-brain barrier to target basal ganglia neurons, mimicking anti-streptolysin O responses.^[139] Symptoms often remit with antibiotic treatment of the preceding infection but can recur with reinfections.^[140] Globally, these sequelae impose a heavy burden, particularly RHD, which affects an estimated 55 million people and causes approximately 360,000 deaths annually, with over 90% of cases occurring in low- and middle-income countries due to limited access to diagnostics and antibiotics.^[141] PSGN contributes to acute kidney injury in endemic areas, while PANDAS adds to pediatric mental health challenges, underscoring the need for early intervention in streptococcal infections.^[142]

Diagnosis

Culture and Serological Methods

Streptococci are typically isolated from clinical specimens such as throat swabs, blood, or wound exudates using enriched media to support their fastidious growth. Primary cultivation occurs on blood agar plates, where the organisms produce characteristic hemolytic patterns after 24-48 hours of incubation at 37°C in 5% CO₂; beta-hemolysis, indicated by clear zones around colonies, is observed in groups A, B, C, and G, while alpha-hemolysis (partial hemolysis with a greenish hue) is typical for Streptococcus pneumoniae.^[1]^[143] For Group B Streptococcus (GBS), selective enrichment broths like LIM (Todd-Hewitt broth supplemented with colistin and nalidixic acid) are used to suppress normal flora, followed by subculture onto sheep blood agar to enhance recovery rates up to 90% in screening scenarios.^[144]^[145] A key rapid diagnostic method for group A Streptococcus (GAS) pharyngitis is the rapid antigen detection test (RADT), which detects group A carbohydrate antigen directly from throat swabs. RADTs provide results in 5-15 minutes with specificity exceeding 95%, but sensitivity ranges from 70-95%, necessitating backup throat culture for negative results in children under IDSA guidelines to avoid missing infections.^[146]^[147] The 2025 Infectious Diseases Society of America (IDSA) guidelines recommend using a clinical scoring system, such as the modified Centor criteria, to assess pharyngitis patients and determine the need for testing, aiming to reduce unnecessary antibiotic use by identifying low-risk cases.^[148] Identification begins with microscopic examination via Gram staining, revealing gram-positive cocci arranged in pairs or chains, a morphology consistent across streptococcal species.^[1] The catalase test is negative for all streptococci, distinguishing them from staphylococci, as no bubbling occurs upon addition of hydrogen peroxide.^[143] For presumptive identification of alpha-hemolytic streptococci as S. pneumoniae, optochin susceptibility testing uses a disk impregnated with ethylhydrocupreine hydrochloride; a zone of inhibition ≥14 mm indicates sensitivity, with >95% specificity, while bile solubility tests confirm by rapid dissolution of colonies in 2-10% sodium deoxycholate due to autolysin activity.^[143] For Group A Streptococcus (GAS), a bacitracin disk test is employed; GAS shows sensitivity with a zone of inhibition due to its lack of resistance to the antibiotic, achieving specificity greater than 95% when combined with beta-hemolysis observation.^[149]^[150] Serological methods, pioneered by Rebecca Lancefield in the 1930s, classify beta-hemolytic streptococci into groups A through H based on cell wall carbohydrate antigens using group-specific antisera.^[151] The traditional Lancefield precipitin test involves extracting antigens via acid or enzyme treatment of bacterial suspensions, followed by reaction with antisera to form visible precipitates, confirming groups with over 98% accuracy in reference labs. Modern alternatives include latex agglutination assays, where bacterial extracts or direct colonies are mixed with latex particles coated in group-specific antibodies, yielding rapid clumping within minutes for groups A, B, C, and G with sensitivities of 95-99% and specificities exceeding 97%.^[152]^[153] These culture and serological approaches, while foundational, are limited by incubation times of 24-48 hours, which delay diagnosis, and reduced sensitivity (down to 70-80%) in patients pretreated with antibiotics, as prior antimicrobial exposure can inhibit growth.^[154]^[155]

Molecular and Genomic Diagnostics

Molecular and genomic diagnostics for Streptococcus species leverage nucleic acid-based techniques to enable rapid, specific identification and characterization, surpassing the limitations of traditional phenotypic methods by targeting genetic markers directly from clinical samples. These approaches are particularly valuable for detecting fastidious or low-abundance streptococci in complex matrices like respiratory secretions, where conventional culture may fail due to prior antibiotic exposure or viability issues.^[156] Polymerase chain reaction (PCR) assays, including species-specific and multiplex formats, form the cornerstone of molecular detection for Streptococcus. For instance, primers targeting the spy gene (spy1258) in Streptococcus pyogenes provide high specificity for group A Streptococcus identification, amplifying a 407 bp product that confirms presence in clinical isolates with over 80% sensitivity in validated studies.^[157] Similarly, multiplex PCR panels target genes like lytA for S. pneumoniae and sdaB for S. pyogenes, allowing simultaneous detection of multiple streptococcal species alongside other respiratory pathogens in blood or sputum samples, with amplicon sizes of 73-74 bp enabling real-time quantification.^[158] These assays facilitate group-level typing, such as distinguishing beta-hemolytic streptococci, and are adaptable for point-of-care use in pharyngitis or invasive infections.^[159] Sequencing-based methods enhance diagnostic precision through whole-genome sequencing (WGS) and multilocus sequence typing (MLST). WGS of S. pneumoniae isolates accurately predicts serotypes by analyzing capsule biosynthesis loci, achieving over 95% concordance with traditional serotyping and enabling outbreak source tracking via single-nucleotide polymorphism analysis.^[160] MLST, particularly core-genome MLST (cgMLST) schemes, sequences fragments of 1,000+ housekeeping genes to assign sequence types (STs), with thresholds of <5 allelic differences identifying outbreak clusters in S. pyogenes populations, as demonstrated in surveillance of UK and Dutch isolates.^[161] These techniques support strain epidemiology without relying on phenotypic variability. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) offers rapid species-level identification by generating protein spectra from bacterial colonies, correctly classifying diverse Streptococcus isolates including S. pneumoniae and viridans group species with >90% accuracy using databases like Bruker or VITEK.^[162] For challenging cases in the Mitis or Bovis groups, it provides preliminary typing that can be confirmed by PCR or sequencing, reducing turnaround time to minutes post-culture. Recent advancements in 2024 include metagenomic enrichment via probe-based next-generation sequencing (NGS) for respiratory panels, which boosts detection of S. pneumoniae in nasopharyngeal swabs by 19.7-fold through targeted amplification of pathogen nucleic acids, identifying infections in 85% of cases where standard metagenomics yields only 73%.^[163] These molecular tools confer advantages such as detection of non-viable DNA from treated infections, identification of virulence-associated genes for risk stratification, and real-time outbreak surveillance, complementing slower culture methods in clinical settings.^[156] Their integration into syndromic panels has improved diagnostic yield for streptococcal diseases, particularly in polymicrobial respiratory contexts.^[163]

Treatment

Antibiotic Susceptibility and Therapy

Streptococci, particularly beta-hemolytic groups such as Streptococcus pyogenes (group A Streptococcus, GAS), exhibit high susceptibility to penicillin, with minimum inhibitory concentrations (MICs) typically ≤0.12 μg/mL, and no naturally occurring resistant strains have been identified to date.^[164]^[165] Beta-lactam antibiotics remain the first-line agents for treating infections caused by non-pneumococcal streptococci due to their consistent efficacy and low resistance rates among these pathogens.^[166] Standard therapy for GAS pharyngitis involves oral penicillin V at 500 mg two to three times daily for 10 days or a single intramuscular dose of benzathine penicillin G (1.2 million units for adults), achieving bacteriological cure rates exceeding 90%.^[167]^[168] For streptococcal meningitis, intravenous ceftriaxone (2 g every 12 hours in adults) is recommended as empiric therapy, with de-escalation to penicillin once susceptibility is confirmed, due to its broad coverage and favorable cerebrospinal fluid penetration.^[169] In patients with penicillin allergy, macrolides such as erythromycin (250 mg four times daily for 10 days) or azithromycin (500 mg on day 1 followed by 250 mg daily for 4 days) serve as alternatives, though efficacy may be slightly lower owing to emerging resistance patterns.^[170]^[171] For Streptococcus pneumoniae, pneumococcal conjugate vaccines (PCVs) like PCV13 have significantly reduced the prevalence of antibiotic-resistant strains by targeting serotypes commonly associated with resistance, leading to declines in invasive infections by over 80% in vaccinated populations.^[172] Globally, macrolide resistance among pneumococcal isolates stands at approximately 30%, necessitating careful selection of alternatives like fluoroquinolones in regions with high prevalence.^[173] The 2025 Infectious Diseases Society of America (IDSA) guidelines for GAS pharyngitis endorse amoxicillin as the preferred oral beta-lactam (50 mg/kg/day divided twice daily for 10 days in children, up to 1 g/day in adults) over penicillin V due to improved palatability and adherence, while maintaining penicillin as the cornerstone for susceptible strains.^[147]^[167] Resistance trends indicate stable penicillin susceptibility across streptococcal species, though vigilance for macrolide non-susceptibility is advised in therapy selection.^[165]

Management of Resistance and Complications

Antibiotic resistance in Streptococcus species remains a significant clinical challenge, though beta-lactamase production is rare and typically not the primary mechanism of resistance; instead, alterations in penicillin-binding proteins mediate beta-lactam resistance in pathogens like S. pneumoniae and viridans group streptococci.^[174]^[175] Macrolide resistance in group A Streptococcus (GAS), often conferred by the erm(B) gene, has shown variable prevalence, peaking at 26-44% in invasive and non-invasive isolates during the early 2000s in certain regions.^[176] For S. pneumoniae, penicillin non-susceptibility rates exhibit global heterogeneity, ranging from 0% to over 60% in surveillance data from multiple countries, with overall resistance around 36% in recent meta-analyses.^[173]^[177] Management of resistant Streptococcus infections prioritizes alternative antibiotics with reliable activity; vancomycin and linezolid are effective options for multidrug-resistant strains, including penicillin-non-susceptible S. pneumoniae and macrolide-resistant GAS, demonstrating comparable efficacy to standard therapies in clinical settings.^[178]^[179] In severe cases like necrotizing fasciitis caused by GAS, clindamycin is recommended adjunctively to suppress toxin production by inhibiting protein synthesis, even in strains with inducible resistance, thereby improving outcomes in animal models and human studies.^[180]^[181] Complications from Streptococcus infections, such as streptococcal toxic shock syndrome (STSS), often require multimodal interventions; intravenous immunoglobulin (IVIG) serves as an adjunctive therapy in STSS by neutralizing superantigens, reducing mortality from approximately 34% to 16% in observational cohorts.^[182] For suppurative complications like abscesses in S. anginosus group or GAS infections, prompt surgical drainage is essential to remove necrotic tissue and pus collections, combined with antibiotics to achieve cure rates exceeding 90% in appropriately managed cases.^[183]^[184] Prevention of non-suppurative sequelae, such as acute rheumatic fever (ARF) following GAS pharyngitis, involves vigilant post-infection monitoring with anti-streptolysin O titers and echocardiography for subclinical carditis, alongside secondary prophylaxis with intramuscular benzathine penicillin G every 3-4 weeks for at least one year in affected individuals.^[185]^[186] Global surveillance efforts have intensified in the post-pandemic era, with the World Health Organization's 2025 Global Antimicrobial Resistance and Use Surveillance System (GLASS) report emphasizing real-time tracking of Streptococcus resistance patterns, noting increases in over 40% of monitored pathogen-antibiotic combinations since 2018 and calling for enhanced laboratory capacity in low-resource settings.^[187]^[188]

Prevention

Vaccination Strategies

Vaccination strategies against Streptococcus species primarily target the most clinically significant pathogens, including S. pneumoniae, S. pyogenes, and S. agalactiae, through licensed vaccines or candidates in development that aim to elicit protective immunity against invasive diseases and sequelae.^[189] These approaches leverage polysaccharide conjugates, protein-based formulations, or emerging nucleic acid technologies to address bacterial colonization and infection, with efficacy varying by pathogen due to antigenic diversity.^[190] For Streptococcus pneumoniae, the leading cause of bacterial pneumonia and meningitis, pneumococcal conjugate vaccines (PCVs) such as PCV13, PCV20, and PCV21 are widely licensed and recommended, particularly for children and adults aged ≥50 years as of the 2025 ACIP updates, demonstrating 70-90% efficacy against invasive pneumococcal disease caused by vaccine serotypes.^[191]^[192] PCV13 targets 13 serotypes and has been instrumental in reducing global disease burden through herd immunity, while higher-valent versions like PCV20 (20 serotypes) and PCV21 (21 serotypes) expand coverage for adults, including those previously vaccinated with lower-valent PCVs or the polysaccharide vaccine PPSV23.^[193] PPSV23, a 23-valent polysaccharide vaccine, is approved for adults and immunocompromised individuals, offering protection against non-invasive pneumonia but with lower immunogenicity in younger populations compared to conjugates.^[194] No licensed vaccine exists for Streptococcus pyogenes (group A Streptococcus, or GAS) as of November 2025, despite ongoing efforts to prevent pharyngitis, rheumatic fever, and invasive infections, as historical candidates faced challenges in achieving broad serotype coverage.^[190] A promising mRNA-lipid nanoparticle (LNP) vaccine candidate, encoding five conserved GAS antigens including M-protein derivatives and SpyAD, was reported in Nature in July 2025, showing robust immunogenicity and preclinical protection in animal models against multiple serotypes; by mid-2025, it had entered phase I clinical evaluation.^[68]^[195] Human challenge models for Strep A were initiated in Melbourne in September 2025 to accelerate vaccine testing.^[196] For Streptococcus agalactiae (group B Streptococcus, or GBS), which causes neonatal sepsis and maternal infections, no licensed vaccine exists as of November 2025, and maternal immunization during pregnancy remains the primary strategy in development, with capsular polysaccharide-protein conjugate vaccines in phase 2 trials targeting serotypes Ia, Ib, II, III, and V to transfer antibodies to newborns.^[189] Candidates like Pfizer's GBS6 have demonstrated immunogenicity and safety in pregnant women, aiming to prevent early-onset GBS disease with estimated 70-80% efficacy based on surrogate endpoints.^[197] The World Health Organization's 2017 Preferred Product Characteristics (PPC) for GBS vaccines emphasize affordable maternal formulations for low-resource settings, guiding trial designs to achieve at least 80% coverage of circulating serotypes globally.^[198] Key challenges in Streptococcus vaccine development include extensive serotype diversity, which limits coverage of circulating strains—such as over 100 pneumococcal serotypes or 200+ GAS M-types—necessitating multivalent or conserved-antigen approaches.^[199] Achieving cross-protection across serotypes remains difficult, as antibodies elicited by one variant often show limited neutralization of heterologous strains, complicating herd immunity and requiring ongoing surveillance of vaccine escape mutants.^[200]

Infection Prevention Measures

Basic hygiene practices, such as regular handwashing with soap and water for at least 20 seconds and adherence to respiratory etiquette including covering coughs and sneezes with a tissue or elbow, are fundamental to reducing the transmission of Streptococcus species, particularly Group A Streptococcus (GAS) through respiratory droplets.^[201]^[202] These measures are especially critical in community settings like schools and households where close contact facilitates spread.^[201] For Group B Streptococcus (GBS), prevention of neonatal early-onset disease relies on targeted clinical interventions during pregnancy. Universal screening via rectal and vaginal swabs is recommended between 35 and 37 weeks of gestation to identify maternal GBS colonization, enabling risk-based management.^[203]^[204] Positive screening results prompt intrapartum antibiotic prophylaxis, typically with intravenous penicillin or alternatives for allergic individuals, which has reduced the incidence of GBS early-onset disease in newborns by more than 80% since the implementation of national guidelines.^[205] Outbreak control for invasive GAS infections involves prompt public health responses, including contact tracing to identify and monitor close contacts of cases, often offering antibiotic prophylaxis to high-risk individuals within 24 hours of notification.^[206] In educational settings, children diagnosed with strep throat (GAS pharyngitis) are excluded from school until at least 24 hours after starting antibiotic therapy to prevent further transmission.^[207] Global efforts to curb Strep A infections emphasize integrated prevention strategies tailored to low-resource settings, as outlined in the World Health Organization's ongoing roadmap initiatives updated in 2025, which prioritize accessible diagnostics, hygiene promotion, and outbreak surveillance to address disproportionate burdens in vulnerable populations.^[208]^[195]

Genomics and Molecular Biology

Genome Structure and Variation

The genomes of Streptococcus species are typically organized as a single circular chromosome, with sizes ranging from 1.8 to 2.3 Mb and encoding approximately 1,800 to 2,200 protein-coding genes.^[209] The GC content varies between 35% and 44% across species, reflecting adaptations to different host environments and ecological niches.^[209] For instance, S. pyogenes genomes average around 1.85 Mb with 38.5% GC, while S. agalactiae strains reach up to 2.16 Mb and 35.6% GC.^[209] This compact structure supports efficient replication and metabolic versatility in diverse pathogenic and commensal contexts. The core genome of Streptococcus, conserved across strains within a species, consists of approximately 1,200 to 1,400 genes involved in essential functions such as replication, transcription, and basic metabolism.^[209] In contrast, the pan-genome expands significantly due to accessory genes, often comprising 20-25% of total content and acquired through mobile genetic elements like bacteriophages and plasmids.^[209] These elements introduce intraspecies diversity, with lineage-specific genes reaching up to 21% in some analyses, enabling adaptation to host immune pressures and environmental changes without disrupting core processes.^[209] Genomic variation in Streptococcus is prominently driven by horizontal gene transfer, which facilitates the integration of serotype-specific islands. A key example is the cps locus in S. pneumoniae, a variable genomic island (2-30 kb) located between the dexB and aliA genes, encoding serotype-specific enzymes for capsular polysaccharide synthesis that confer antigenic diversity and immune evasion.^[210] This locus exemplifies how localized recombination hotspots contribute to strain-level differences, with over 90 serotypes identified through such variations.^[210] Advances in sequencing have cataloged hundreds of Streptococcus genomes in public databases, revealing patterns of diversity across species.^[209] As of 2025, recent genomic studies on S. pyogenes have highlighted mutations in regulatory genes like covRS that enhance invasiveness, correlating with surges in severe infections and underscoring the role of ongoing variation in disease emergence.^[211]

Genetic Exchange Mechanisms

Streptococcus species employ several mechanisms for genetic exchange, enabling the acquisition of new genetic material that contributes to their adaptability and pathogenicity. These processes include bacteriophage-mediated transfer, natural transformation, and conjugation, each playing distinct roles in horizontal gene transfer within streptococcal populations. Bacteriophages, particularly temperate phages, are prominent vectors for genetic exchange in Streptococcus. In Group A Streptococcus (GAS, S. pyogenes), temperate bacteriophages commonly integrate into the bacterial genome as prophages, establishing lysogeny and conferring lysogenic conversion by carrying virulence factors such as superantigen toxins. For instance, the speC gene encoding streptococcal pyrogenic exotoxin C (SpeC), a potent superantigen implicated in toxic shock-like syndrome, is borne on temperate phages like φNIH1, which lysogenize GAS strains and enhance their pathogenic potential upon induction. Lysogeny is widespread across streptococci, with prophages in S. pneumoniae often comprising up to 10-15% of the genome and facilitating the stable inheritance of phage-encoded genes during bacterial replication. These temperate phages can excise under stress conditions, such as antibiotic exposure or host cell interactions, releasing virions that transduce genetic elements to new hosts, thereby disseminating toxin and virulence genes.^[212]^[213]^[214] Natural transformation represents another key mechanism, especially in S. pneumoniae, where cells develop competence—a transient physiological state for DNA uptake—under specific environmental cues. Competence is regulated by the Com regulon, a network of over 100 genes activated by the competence-stimulating peptide (CSP), a quorum-sensing signal that accumulates at high cell densities to synchronize population-level transformation. Recent studies have elucidated how quorum sensing integrates with stress responses, such as nutrient limitation or DNA damage, to trigger competence via the ComDE two-component system, where CSP binds the ComD receptor to induce the alternative sigma factor ComX. Transformation is less prevalent in other streptococci like GAS but occurs under similar quorum-regulated conditions.^[215]^[216]^[217] This process allows S. pneumoniae to incorporate exogenous DNA, including from lysed sibling cells, via homologous recombination of fragments typically 2-10 kb in size, with multiple events enabling significant genomic adaptation and promoting rapid adaptation. Conjugation, while rarer in core streptococci compared to enterococci, facilitates plasmid and integrative conjugative element (ICE) transfer, often conferring antibiotic resistance. In streptococci such as S. anginosus and S. pneumoniae, conjugative plasmids and Tn916-like ICEs mediate direct cell-to-cell transfer of resistance genes, including erm(B) for macrolide resistance, through type IV secretion systems. These elements are mobilized at low frequencies (10^{-6} to 10^{-8} per donor cell) but enable interspecies spread, as seen in the conjugation of erm(B)-carrying ICEs from S. anginosus to related streptococci. Unlike the efficient conjugation in enterococci, streptococcal systems rely more on ICEs than broad-host-range plasmids, limiting but not eliminating resistance dissemination. This mechanism contributes to the slower evolution of multidrug resistance in streptococci relative to Gram-negative bacteria.^[218]^[219]^[220] These genetic exchange mechanisms collectively drive streptococcal evolution by introducing variability that enhances survival and virulence. For example, in S. pneumoniae, phage-mediated transfer can facilitate serotype switching through the packaging and transduction of capsule biosynthesis (cps) locus fragments, allowing evasion of host immunity and vaccines, as observed in shifts from serotype 19A to non-vaccine types post-PCV introduction. Such exchanges underscore the role of horizontal transfer in generating diverse clones, with implications for antimicrobial resistance spread and epidemic potential across Streptococcus species.^[221]^[222]

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Streptococcus pyogenes is a major human-specific bacterial pathogen that causes a wide array of manifestations ranging from mild localized infections to life- ...Missing: genus | Show results with:genus
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Streptococcus pneumoniae has a complex cell wall that plays key roles in cell shape maintenance, growth and cell division, and interactions with components ...
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Laboratory Growth and Maintenance of Streptococcus pyogenes ...
S. pyogenes is grown at 37°C, using solid media like TSA with sheep blood, or liquid media, and requires specific nutrients. It is a facultative anaerobe.
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Streptococcus - an overview | ScienceDirect Topics
After 18–24 h of incubation at 35–37 °C on blood agar, typically grayish-white, smooth, glossy, and translucent colonies appear with zones of α/β-hemolysis or ...
[38]
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Jul 21, 2016 · This review aims to summarize and compare the central carbohydrate metabolic and amino acid biosynthetic pathways of a selected group of streptococcal species.
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S. pyogenes, also referred to as β-hemolytic group A streptococci, are strictly human pathogens with a global distribution and high prevalence of infection.
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Streptococcus abundance and oral site tropism in humans and non ...
Jan 17, 2025 · Streptococcus species play a major role in colonizing tooth surfaces and initiating dental plaque biofilm formation in humans. Recently, ...
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Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory, gastrointestinal, and genitourinary tracts; and the skin.Missing: habitats | Show results with:habitats
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Of the 154 volunteers studied, 110 (71%) presented with oropharyngeal carriage of macrolide-resistant VGS. In 75 carriers, only one unique macrolide-resistant ...
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1. In the oral cavities of healthy children, approximately 98% of streptococci belonged to two VGS groups, i.e. mitis and salivarius groups.
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Re-framing the importance of Group B Streptococcus as a gut ...
Mar 4, 2024 · In this review, we synthesize current knowledge of the diverse body sites occupied by GBS as a pathogen and as a commensal.
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Apr 24, 2019 · Characterization of pig saliva as the major natural habitat of Streptococcus suis by analyzing oral, fecal, vaginal, and environmental microbiota
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Genetic Research Sheds Light on Group BStreptococcus
Group B Streptococcus (GBS) causes mastitis in cattle, neonatal meningitis in humans, and can be deadly for newborns. It also infects fish, and can cause ...
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Streptococcus catagoni sp. nov., isolated from the respiratory tract of ...
Sep 17, 2020 · Novel catalase-negative, Gram-stain-positive, beta-haemolytic, coccus-shaped organisms were isolated from Chacoan peccaries that died from ...
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Habitat. Streptococcus thermophilus is highly adapted to the dairy environment and in the wild, can only be isolated from milk. It is found at low levels in ...
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Cool, moist conditions prolonged the survival of Streptococcus faecalis in soil for at least 12 weeks, whereas freezing was lethal, with the populations being ...
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The aim of this study was to screen oral bacteria colonizing healthy children for their use as potential oral probiotics.
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Often, oral commensal streptococci antagonize cariogenic and periodontal pathogens such as Streptococcus mutans and Porphyromonas gingivalis, respectively.
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Jul 31, 2019 · In this narrative review we further address the efficacy of probiotics and highlighted in part the probiotic bacterium Streptococcus ...
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The risk of pneumococcal disease was high among older adults and adults with certain risk conditions, particularly immunocompromising conditions.Missing: host elderly
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Streptococcus pneumoniae's Virulence and Host Immunity - NIH
S. pneumoniae has a large selection of virulence factors that promote adherence, invasion of host tissues, and allows it to escape host immune defenses.
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Aug 27, 2025 · Various studies have shown that patients with CAP often exhibit reduced microbial diversity, increased bacterial load, and overgrowth of ...
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Jan 14, 2025 · Group A Streptococcus (GAS) refers to the bacterial species "Streptococcus pyogenes," which is a gram-positive bacterium that grows in pairs ...
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M Protein and Other Surface Proteins on Streptococcus pyogenes
Jun 1, 2022 · Molecules on the surface of S. pyogenes range from a complex coiled coil modular structure, like the M protein, to conventional globular proteins and ...
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Pathogenesis, epidemiology and control of Group A Streptococcus ...
Mar 9, 2023 · It consists of a conserved carboxy terminal that confers covalent attachment of M protein to the cell wall and a hypervariable surface-exposed N ...
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Jul 29, 2025 · A group of researchers led by The University of Osaka have identified a novel genetic mutation in Streptococcus pyogenes, a common bacterium ...
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Jul 28, 2022 · In an experimental mouse necrotizing fasciitis model, S. pyogenes has been found to strongly upregulate the expression of SLS, along with SpeB ...
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Sep 7, 2022 · Life-threatening infections caused by Streptococcus pyogenes (group A streptococcus) include scarlet fever, bacteremia, pneumonia, necrotizing fasciitis, ...
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Jul 1, 2025 · Here, we evaluate the immunogenicity and preclinical efficacy of a multicomponent mRNA-LNP vaccine formulation based on the GAS vaccine, Combo#5.
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Streptococcus pyogenes appears to be almost exclusively restricted to humans, with few reports on isolation from animals.
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Jun 14, 2012 · The Lancefield Group B carbohydrate (GBC) is a peptidoglycan-anchored antigen that defines this species as a Group B Streptococcus.
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Group B Streptococcus: Virulence Factors and Pathogenic Mechanism
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The capsule also has pili, which are hair-like structures that help the bacteria attach to a host cell. Furthermore, S agalactiae makes beta-hemolysin, a pore- ...
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Group B Streptococci recto-vaginal colonization, antimicrobial ...
During pregnancy, approximately 10–30% of pregnant women are colonized with GBS in the vaginal and rectum area asymptomatically and 60% of their babies are ...
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Infant Group B Streptococcal Disease Incidence and Serotypes ...
The pooled incidence of invasive GBS disease in infants was 0.49 per 1000 live births (95% confidence interval [CI], .43–.56), and was highest in Africa (1.12) ...
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Risk factors for EOD disease include maternal vaginal or rectal GBS colonization, GBS bacteriuria during pregnancy, prolonged labor, prolonged rupture of ...
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S. agalactiae contains the CAMP factor, a pore-forming toxin first identified in this bacterium. The CAMP reaction is based on the co-hemolytic activity of the ...
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Group B Streptococcus (GBS; Streptococcus agalactiae ) is a major neonatal and opportunistic bacterial pathogen of humans and an important cause of mastitis ...
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Oct 4, 2022 · Streptococcus pneumoniae is a Gram positive bacterium; order Lactobacillales, family Streptococcaceae.
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Streptococcus pneumoniae (pneumococci) bacteria are gram-positive, alpha-hemolytic, aerobic, encapsulated diplococci. Pneumococci cause many cases of otitis ...
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S. pneumonia is a lancet-shaped, gram-positive, facultative anaerobic organism that typically occurs in pairs or short chains. Encapsulated S. pneumonia is ...Missing: alpha- hemolytic
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PPSV23 contains polysaccharide antigen from 23 types of pneumococcal bacteria. It contains 25 µg of each antigen per dose and contains 0.25% phenol as a ...
[84]
Streptococcus pneumoniae serotypes
Global Pneumococcal Sequence Cluster ; 2, 1, 52 ; 3, 3, 15A, 22F, 23F, 31, 52 ; 4, 14, 15B/C, 19A, 52 ; 5, 3, 6A, 7C, 15B/C, 17F, 19A, 23A, 23B, 23F, 35B, 52.
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Nasopharyngeal colonization by Streptococcus pneumoniae in ...
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Pneumococcal Infections (Streptococcus pneumoniae)
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Geographical migration and fitness dynamics of Streptococcus ...
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Capsular Serotyping of Streptococcus pneumoniae Using the ... - JoVE
Jul 22, 2013 · The Quellung reaction is the gold standard technique for serotyping Streptococcus pneumoniae. This technique utilizes a microscope and specific pneumococcal ...
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lytA - Autolysin - Streptococcus pneumoniae serotype 4 ... - UniProt
Sep 26, 2001 · Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation.
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Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus.
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Current prevalence and therapeutic strategies for porcine ...
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Streptococcus suis, an important pig pathogen and emerging ...
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Strangles is a highly infectious disease of Equidae characterized by abscessation of the lymphoid tissue of the upper respiratory tract.
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The upper respiratory disease commonly referred to as strangles is caused by Streptococcus equi subsp equi. Less commonly, the bacteria affect lymph nodes.
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However, when analyzing the cleavage of IgG during bacterial growth in TH medium, only five of the tested strains expressed the IgG‐degrading activity (AP1, ...<|separator|>
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Adherence to host cells is the first step in bacterial colonization. Lipoteichoic acid and protein F, both cell wall components of GAS, are crucial for ...
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Therefore, teichoic acid has been revealed to influence the colonization of Gram-positive bacteria, similar to LPS in Gram-negative bacteria (Bucher et al., ...
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Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract. ... Rga is a regulator of adherence and pilus formation ...
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The organism produces a range of colonization and virulence factors, including the polysaccharide capsule, surface proteins and enzymes, and the toxin ...
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Feb 7, 2018 · These include urinary tract infections, bacteremia, sepsis, mastitis ... Bacterial hyaluronidase promotes ascending GBS infection and preterm ...
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Group A Streptococcus interactions with the host across time and ...
This review discusses molecular interactions between the host and pathogen to summarize how infection varies across tissue and stages of inflammation.
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Group A streptococcus (GAS) strains secrete the protein streptokinase (SK), which functions by activating host human plasminogen (hPg) to plasmin (hPm), ...
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Group A Strep in Fibrin Clots & Plasminogen for Fibrinolysis
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Jul 24, 2025 · Streptococcus pyogenes causes mild human infections as well as life-threatening invasive diseases. Since the mutations known to enhance ...
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Scarlet Fever - StatPearls - NCBI Bookshelf - NIH
Scarlet fever is an infection caused by Streptococcus pyogenes (group A Streptococcus or "GAS"), which is a bacterium specific to humans.
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Sep 7, 2022 · Cellulitis and erysipelas can be mild or moderately severe, while necrotizing fasciitis, myonecrosis and StrepTSS are life-threatening. This ...
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Aug 5, 2025 · Mortality rates. In the most recent 5 years, the mortality rate of streptococcal necrotizing fasciitis has been around 15 to 20%. It increases ...
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The COVID-19 pandemic lockdown created a unique and unexpected opportunity to investigate infectious immunity following a prolonged period of reduced exposure ...
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Mar 12, 2024 · Evidence from multiple studies support the hypothesis of molecular mimicry between the group A streptococcus and the heart and cardiac myosin in ...
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Acute rheumatic fever (ARF) is an abnormal immunologic response to group A Streptococcus (GAS) infections, most commonly tonsillopharyngitis.
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Oct 9, 2022 · [2] Some theories suggest that these immune complexes become deposited in kidney glomeruli reaching through the circulation. Others claim ...Continuing Education Activity · Pathophysiology · History and Physical · Evaluation
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Dec 6, 2021 · Post-streptococcal glomerulonephritis (PSGN) is an immune-complex mediated inflammation that used to be considered one of the commonest causes of acute ...
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For a child to have PANDAS, there needs to be a sudden onset or worsening of OCD, tics, or both, and a strep infection. If a child is found to have strep around ...What are PANS and PANDAS? · How are PANS and PANDAS...
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Pediatric autoimmune neuropsychiatric disorders associated with ...
PANDAS is clinically characterized by sudden and major changes in personality, behavior and movement in a patient with streptococcal infection.
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Aug 21, 2022 · Globally, in 2005 it was estimated that at least 663,000 cases of invasive Group A Streptococcal disease occurred each year, which resulted in ...
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Feb 10, 2016 · Streptococci are generally grown on agar media supplemented with blood. This technique allows the detection of β-hemolysis, which is important ...Streptococcus Pyogenes... · Lancefield Antigen... · Serologic Tests
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A selective medium containing Todd-Hewitt broth, sheep blood, nalidixic acid, and gentamicin sulfate was found to enhance significantly the isolation of group ...
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Sep 15, 2022 · Streptococcus pyogenes can be differentiated from other non-group A β-hemolytic streptococci by their increased sensitivity to bacitracin. The ...
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Jul 1, 2016 · Although many laboratories use bacitracin sensitivity as a presumptive identification test for GAS, it may give false positive results with ...
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A SEROLOGICAL DIFFERENTIATION OF HUMAN AND ... - PubMed
The specific group classification is made possible by employing two special reagents: (a) extracts prepared by treatment of the bacteria with hot hydrochloric ...
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Rapid grouping of beta-hemolytic streptococci by latex agglutination
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Latex agglutination tests (hereinafter called latex tests) have been used for identification and grouping of many clinically important microorganisms, ...
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Increasing amounts of genomic data for streptococci will aid the re-evaluation of known PCR and sequencing targets as well as identification of new ones for ...
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Aug 26, 2022 · PCR detection of Spy 1258 gene which has 407 bp Product length (Figure 4) showed 42 samples positive (82.4%) of 51 S. pyogenes samples were ...
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Simultaneous Genetically Detection of Streptococcus pyogenes ...
This study describes the development and evaluation of a single-tube, three-target, multiplex touch PCR assay that can simultaneously detect S. pneumoniae, H. ...Introduction · Material And Methods · Table 2
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Whole genome sequencing of Streptococcus pneumoniae: development, evaluation and verification of targets for serogroup and serotype prediction using an ...
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Oct 10, 2023 · Multilocus sequence typing of Streptococcus pyogenes representing most known emm types and distinctions among subpopulation genetic structures.
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In this study, MALDI-TOF mass spectra were generated for a diverse panel of whole genome sequenced pneumococcal isolates using the bioMerieux VITEK MS in ...
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1 For individuals with severe penicillin allergy, alternative therapy includes macrolide or azalide antibiotics, which include erythromycin, clarithromycin ...
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Resistance to beta-lactams in pneumococci and viridans streptococci is mediated by mutations in genes encoding penicillin-binding proteins (pbp) and alterations ...2. Overview Of Results · S. Pyogenes (gas) Infections · S. Agalactiae (gbs)...<|separator|>
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An mRNA vaccine encoding five conserved Group A Streptococcus ...
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A Review of Streptococcus pyogenes: Public Health Risk Factors ...
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a link between quorum sensing and DNA processing genes
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Dissemination of Tn916-Related Integrative and Conjugative ...
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