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EXIT procedure

The Ex utero Intrapartum Treatment (EXIT) procedure is a specialized obstetric surgical technique performed during a cesarean section, in which the is partially delivered through a uterine incision while remaining connected to the via an intact , allowing for controlled interventions—such as airway establishment via or tracheostomy—to address life-threatening congenital anomalies before complete separation from maternal circulation. Developed to mitigate the risks of immediate postnatal airway compromise, EXIT converts a potential into a managed elective process, providing a critical 60- to 90-minute window for fetal oxygenation supported by the . First described in in the early and initially performed in 1990 at for a with a large teratoma, the procedure has evolved into a at select tertiary fetal centers worldwide, requiring multidisciplinary teams including obstetricians, anesthesiologists, neonatologists, and pediatric surgeons or otolaryngologists. It is indicated primarily for conditions causing potential airway obstruction at birth, such as congenital high airway obstruction syndrome (CHAOS), large or thoracic masses (e.g., teratomas, lymphangiomas, or goiters), congenital diaphragmatic hernia with lung , or rarely, requiring immediate separation. Prenatal via high-resolution and fetal MRI is essential to identify candidates, with delivery typically planned at 37-39 weeks to optimize fetal maturity while minimizing preterm risks. During the procedure, deep maternal induces uterine relaxation to preserve uteroplacental blood flow, enabling partial fetal exteriorization of the head, , and upper through a ; the airway is then secured, and additional interventions like (ECMO) cannulation or mass resection may follow if needed, before cord clamping and full delivery. While has dramatically improved survival rates—reportedly exceeding 90% in experienced centers for appropriately selected cases—it carries significant maternal risks, including an average blood loss of 1 liter (with 6% requiring transfusion), or wound infection (up to 15%), and rare ; fetal risks encompass preterm delivery complications, if airway failure occurs, or cardiac strain from anomalies. Due to its complexity and infrequency (performed in fewer than 1% of high-risk deliveries), demands rigorous preoperative simulation, intraoperative coordination by dual anesthesia and surgical teams, and postoperative intensive care to achieve optimal outcomes.

Background

Definition and Purpose

The Ex utero Intrapartum Treatment (EXIT) procedure is a specialized surgical delivery technique designed to partially extract the through a while preserving placental circulation, thereby allowing for immediate interventions to secure the fetal airway or address cardiopulmonary anomalies before complete separation from the . This approach maintains uteroplacental blood flow, providing the with continued oxygenation from the mother during the critical transition to extrauterine life. The primary purpose of the EXIT procedure is to create a controlled window of 30 to 90 minutes for placental support, enabling clinicians to perform necessary interventions—such as , tracheostomy, or mass resection—without the immediate risk of postnatal that could occur upon cord clamping. Unlike a standard cesarean section, in which the is fully delivered and separated from the almost immediately, the EXIT method delays umbilical cord clamping to sustain this vital oxygenation period, optimizing outcomes for high-risk cases. To achieve this, uterine relaxation is induced using high-dose volatile anesthetics, such as , which inhibit myometrial contractions and preserve uteroplacental without compromising maternal . This mechanism ensures the remains partially within the , with the placental circulation intact, until the intervention is complete. The procedure is commonly indicated for conditions involving potential airway obstruction, such as large cervical masses compressing the trachea.

Historical Development

The concept of a partial cesarean section for fetal interventions, allowing partial delivery of the while maintaining uteroplacental circulation, was first discussed in in 1981, laying the groundwork for advanced procedures. This early conceptualization emerged alongside the pioneering open fetal surgeries at institutions like the , where the focus was on addressing congenital anomalies without full delivery. The EXIT procedure itself was first successfully performed in 1990 at Thomas Jefferson University Hospital in Philadelphia by J.T. Zerella and F.J. Finberg, targeting a fetus with a large cervical teratoma causing potential airway obstruction at birth. This landmark case demonstrated the feasibility of securing the fetal airway during a controlled cesarean delivery, marking a shift from purely experimental fetal interventions to targeted airway management. Pioneers in fetal surgery, including teams led by figures such as Mark I. Evans, contributed to these initial descriptions through their work in prenatal diagnosis and intervention. During the 1990s, the procedure expanded significantly, driven by advancements in prenatal imaging technologies such as high-resolution and fetal MRI, which enabled earlier and more accurate detection of airway-obstructing anomalies. By the early 2000s, integration of (ECMO) as an "EXIT to ECMO" variant became a key milestone, providing cardiopulmonary support for fetuses with severe cardiac or respiratory compromise during the transition to neonatal care. Post-2010, adaptations for congenital high airway obstruction syndrome (CHAOS) further refined the technique, with case reports highlighting improved survival through tracheal reconstruction while on placental support. Over time, the EXIT procedure evolved from an experimental adjunct to —initially for reversing tracheal occlusion in congenital cases—into a standardized, multidisciplinary . The increase in published case reports, facilitated by enhanced diagnostic capabilities, has solidified its role in managing a broader range of fetal anomalies.

Indications and Diagnosis

Primary Indications

The EXIT procedure is primarily indicated for fetal anomalies that predict immediate postnatal airway compromise or cardiopulmonary instability, necessitating intervention while the remains connected to the placental circulation. The most common indications involve head and neck masses, such as teratomas or lymphangiomas, which compress the airway; these large tumors can distort the trachea or , leading to potential obstruction upon delivery, and the approach allows for controlled partial delivery, direct , and securement of the airway via or tracheostomy before cord clamping. Congenital high airway obstruction syndrome (), characterized by laryngeal or tracheal , represents another key indication, often resulting in severe lung hypoplasia due to impaired egress and requiring emergent to facilitate tracheostomy or ex utero intrapartum tracheoplasty, thereby mitigating the risk of fatal at birth. Additional indications include large thoracic masses, such as bronchopulmonary or congenital pulmonary airway malformations, that may cause mediastinal shift and respiratory distress; congenital (CDH) with significant airway compromise following fetal interventions like tracheal occlusion; necessitating immediate separation; and fetuses with complex cardiac anomalies requiring prompt extracorporeal membrane oxygenation () cannulation. In each scenario, the procedure provides a critical window—typically 60 to 90 minutes—of uteroplacental support to stabilize the neonate and avert hypoxic injury. This rare intervention is performed in fewer than 1% of high-risk pregnancies, predominantly at specialized fetal centers equipped with multidisciplinary teams.

Diagnostic Criteria

Prenatal of conditions warranting the EXIT procedure relies on advanced to evaluate fetal airway compromise, particularly in cases involving masses such as teratomas or congenital high airway obstruction (CHAOS). serves as the initial modality, assessing airway patency through visualization of the trachea and , while also measuring to detect or compression indicative of obstruction. Fetal MRI complements by providing detailed characterization of masses, including size, vascularity, and extent of compression on surrounding structures like the trachea and great vessels. A critical quantitative in airway is the tracheoesophageal displacement index (TEDI), calculated as the sum of the lateral and ventral displacements of the tracheoesophageal complex from the ventral aspect of the vertebral body on sagittal MRI or views. A TEDI greater than 12 signals significant distortion and potential need for to secure the airway. In , characterized by intrinsic upper airway obstruction, a narrowed tracheal —typically less than 5 distally—correlates with severe cases, often accompanied by bilateral echogenic lungs and diaphragmatic eversion on . Additional evaluations include monitoring amniotic fluid levels, where may indicate esophageal compression or swallowing impairment due to the mass. Fetal is essential to assess cardiac function, identifying or right heart strain from lung hyperinflation in . Genetic testing, often via , helps rule out associated syndromes such as Fraser or DiGeorge that could influence prognosis. Contraindications for EXIT include lymphatic malformations lacking airway compression, small neck masses under 3.5 cm in diameter without , and non-viable anomalies like , as these do not pose immediate postnatal airway threats or carry excessive maternal risk. Final candidacy determination involves multidisciplinary review after 32 weeks' , weighing fetal lung maturity and viability against procedural risks to the mother, with procedures typically planned at 37 to 39 weeks' to optimize outcomes.

Preparation and Team

Multidisciplinary Approach

The EXIT procedure requires a highly coordinated multidisciplinary to ensure the safety of both the mother and during this complex intervention. The core team typically consists of two separate teams—one focused on maternal care and the other on fetal —along with obstetricians, pediatric surgeons or ear, nose, and throat () specialists, neonatologists, nurses, and support staff such as surgical technicians and respiratory therapists. This collaborative structure often involves 20 to 30 personnel, reflecting the procedure's demands for simultaneous monitoring and intervention across maternal and fetal domains. Specific roles are clearly delineated to optimize efficiency and minimize risks. The obstetrician performs the to partially deliver the while maintaining uteroplacental circulation, while the ENT specialist or pediatric surgeon secures the fetal airway, often through or tracheostomy. Neonatologists oversee fetal ventilation and may initiate (ECMO) if needed, and anesthesiologists maintain uterine relaxation to prevent premature cord clamping. Nurses and technicians support by managing equipment, medications, and monitoring, with preoperative meetings ensuring role assignments and resource availability. Training for these teams emphasizes simulation-based rehearsals at specialized fetal centers, which allow practice of the procedure's unique sequence and contingency planning. Coordination is facilitated through checklists and algorithms akin to the World Health Organization's surgical safety protocols, promoting standardized communication and error reduction. These practices have evolved since the early , with a shift toward formalized multidisciplinary teams that has improved outcomes by decreasing procedural complications. EXIT procedures are exclusively conducted at level IV neonatal intensive care units (NICUs) equipped with comprehensive fetal surgery programs, where advanced resources like ECMO and immediate neonatal support are available. Prominent examples include the Center for Fetal Diagnosis and Treatment at Children's Hospital of Philadelphia and the Texas Children's Fetal Center, both of which have extensive experience in high-risk fetal interventions.

Preoperative Planning

Preoperative planning for the EXIT procedure begins with meticulous patient selection, focusing on fetuses with conditions such as congenital airway obstructions, including cervical teratomas or congenital high airway obstruction syndrome (), where immediate postnatal is critical. Candidates are identified through prenatal imaging like and MRI, with relative contraindications including smaller neck masses under 3.5 cm without evidence of compression. is optimized at 35 to 37 weeks to ensure fetal lung maturity while minimizing preterm risks, as earlier delivery before 32 weeks is generally avoided due to outweighed complications. is obtained through comprehensive multidisciplinary discussions, outlining maternal risks such as hemorrhage with a 6% transfusion rate and fetal risks including potential airway failure. Team simulations are integral, involving mock runs to rehearse airway scenarios, role assignments, and emergency responses, often using for complex cases to enhance coordination among obstetricians, anesthesiologists, neonatologists, and surgeons. Equipment checklists are verified during these sessions, ensuring availability of rigid and flexible bronchoscopes, laryngoscopes, tracheostomy kits, and ECMO setups for cases requiring immediate cardiopulmonary support. These rehearsals typically occur 24 to 48 hours prior to the procedure, allowing for adjustments based on the latest fetal assessments. Maternal preparation emphasizes hemodynamic stability and infection prevention, including placement of two large-bore peripheral lines for fluid resuscitation, blood typing and with type-and-screened products readily available, and administration of prophylactic intravenous antibiotics such as cephalosporins. Fetal monitoring is optimized via continuous or scalp electrode if feasible during , alongside maternal invasive monitoring to maintain uteroplacental . Facility readiness transforms the operating room into a environment, equipped with warming devices like forced-air blankets and amnioinfusion with warmed fluids to prevent fetal , alongside blood products anticipating an average maternal blood loss of 1 L. The setup includes a cesarean tray, neonatal station, and provisions for rapid conversion to a full cesarean section if needed, all coordinated in a specialized fetal care center to support the elective timing post-diagnosis with short-notice finalization.

Procedure

Anesthesia Management

The anesthesia management for the ex utero intrapartum treatment (EXIT) procedure requires specialized strategies to maintain uterine relaxation, ensure uteroplacental , and support both maternal and fetal stability during the partial cesarean delivery. General (GA) is the predominant approach, administered to 214 out of 224 reported cases in a , using high-dose inhalational agents such as , , or at a (MAC) greater than 2 to achieve profound uterine tocolysis while allowing transplacental transfer to provide fetal . These volatile agents cross the effectively, enabling fetal immobilization without compromising placental blood flow, though agents that could cause excessive fetal myocardial depression are avoided. Regional (RA), such as combined spinal-epidural with bupivacaine (10-12 mg), is less common (10 cases) and typically supplemented with intravenous (NTG; 25-100 mcg bolus followed by 1-20 mcg/kg/min infusion) for uterine relaxation, but it may require additional fetal anesthetics like or atropine if transplacental effects are insufficient. A multidisciplinary team, including at least two anesthesiologists—one dedicated to maternal care and another to fetal management—coordinates the procedure to address the dual-patient dynamics. The maternal-focused anesthesiologist monitors hemodynamics invasively via arterial lines in most GA cases (74 reported) and maintains systolic blood pressure between 100-120 mmHg using vasopressors such as phenylephrine (50 mcg boluses or 0.05-0.1 mcg/kg/min infusion) or dopamine (5 mcg/kg/min) to prevent hypotension-induced uteroplacental hypoperfusion. The fetal team prepares for immediate airway intervention, such as intubation with a 2.5 endotracheal tube confirmed by end-tidal CO2, while monitoring fetal status with sterile pulse oximetry (target preductal saturation >40%) and ultrasonography when feasible. Standard maternal monitoring includes blood pressure, oxygen saturation, and end-tidal CO2, with left lateral uterine displacement employed to mitigate aortocaval compression and supine hypotension. Key challenges include balancing deep for surgical relaxation against the risk of maternal , which can arise from high-dose volatiles or NTG and lead to uterine hypoperfusion, though no direct anesthesia-related complications were noted in the reviewed cases. Post-airway securing, tocolysis is reversed by discontinuing inhalational agents or NTG and administering uterotonics like oxytocin (5 units bolus followed by 20 units/L infusion) to restore uterine tone and minimize postpartum hemorrhage, which occurred in 8 of the reviewed cases (requiring transfusion in 5). Fetal Apgar scores reflect the procedure's demands, averaging 5.9 at 1 minute and 8.3 at 5 minutes under , compared to 3.9 and 7.2 under RA, underscoring the need for precise hemodynamic control.

Surgical Steps

The (ex utero intrapartum treatment) involves a specialized cesarean technique that allows for partial fetal extraction while maintaining placental circulation, providing a controlled window for life-sustaining interventions on the before complete separation from the mother. This approach differs from standard cesarean sections by prioritizing uterine relaxation and gradual amniotic fluid decompression to minimize fetal compromise during the process. The procedure begins with a maternal , typically via a Pfannenstiel or low transverse incision to access the , though a vertical midline incision may be used for better exposure in cases of large fetal masses or anterior . Intraoperative confirms placental location to avoid disruption, and the is incised using a specialized stapling device or traditional technique to create an opening while sealing the and minimizing blood loss. The is punctured multiple times for controlled decompression of fluid, preventing sudden fetal decompression that could lead to cardiovascular instability. Following the , the , , and upper torso are gently delivered through the uterine incision, with one arm often included to facilitate positioning, while the lower body and remain within the to preserve uteroplacental and circulation. This partial extraction allows the to continue receiving oxygen and nutrients from the , creating a physiologically stable for . The and are positioned optimally for , and the multidisciplinary team—comprising obstetricians, neonatologists, and otolaryngologists—immediately assesses the airway using direct or to evaluate patency and any obstructing masses. Airway management is then performed while placental support is maintained, typically starting with attempts at endotracheal intubation using a rigid or flexible bronchoscope (e.g., 2.5–3.0 mm diameter) under direct visualization. If intubation fails due to anatomical obstruction, alternatives include tracheostomy placement by an ENT specialist or surgical resection/distraction of compressive masses such as cervical teratomas. Prophylactic surfactant may be administered to support lung function, and in select cases like congenital diaphragmatic hernia (CDH), immediate chest tube placement or extracorporeal membrane oxygenation (ECMO) cannulation can be initiated to address pulmonary hypoplasia or vascular issues. Ventilation is achieved via an Ambu bag or similar device, with flexible bronchoscopy verifying tube position before proceeding. These interventions occur within a critical 30–60 minute window to ensure fetal stability. Once the airway is secured and fetal oxygenation is confirmed stable, the is clamped and divided, allowing full delivery of the to the neonatal team for further . The is then manually removed, followed by closure of the uterine incision with absorbable sutures, restoration of normal uterine tone using oxytocin, and layered closure of the maternal . The total operative time in the operating room typically ranges from 1 to 2 hours, with the intervention phase lasting 45–90 minutes depending on complexity. Variations in may include "EXIT to resection" for direct tumor removal or "EXIT to ECMO" for cardiac anomalies, tailored to the specific fetal .

Postoperative Care

Immediate Interventions

Following the completion of the EXIT procedure, immediate interventions prioritize stabilization of both the mother and neonate to address the physiological stresses of partial uteroplacental separation and surgical delivery. For the mother, is achieved through uterine compression, administration of uterotonics such as oxytocin infusion (typically 7.5-30 units per hour intravenously), and, if necessary, additional measures like B-Lynch sutures for atony. Uterine closure of the site is performed using manual suturing or stapling devices to ensure secure repair and minimize future rupture risk, often under direct visualization to confirm no ongoing bleeding. Tocolysis is reversed promptly after cord clamping by discontinuing agents like or beta-mimetics, with oxytocin initiated to promote uterine contraction and reduce hemorrhage risk. Pain management involves opioid administration, such as or , often via an existing for multimodal analgesia. Maternal , including and levels, are closely monitored for signs of hemorrhage, with indicated if estimated blood loss exceeds 1 liter or drops significantly (e.g., >1 g/dL). Prophylactic intravenous antibiotics, such as cephalosporins, are routinely administered to prevent or wound infection. For the neonate, initial resuscitation is provided by the neonatal team in the operating room if Apgar scores are low or persists, including epinephrine (0.01–0.03 mg/kg intravenously, or 0.05–0.1 mg/kg endotracheally if intravenous access is unavailable) and chest compressions coordinated with ventilation at a rate of 90 compressions per minute, as per (NRP) guidelines. Airway stabilization, often secured intraoperatively via endotracheal or tracheostomy, is continuously monitored postoperatively with , , and clinical assessment to ensure patency and adequate oxygenation. The neonate is then transferred directly to the (NICU) for ongoing support, including or continuation of (ECMO) if initiated for severe respiratory or cardiac compromise. Arterial blood gases (ABGs) are obtained immediately to evaluate acid-base status and oxygenation, while imaging such as chest X-rays or assesses resolution of the underlying anomaly and guides further therapy. A structured handover occurs between the surgical, , and NICU teams, involving a debrief on procedural details, fetal interventions performed, and initial to facilitate seamless transition to intensive care. Maternal typically lasts at least 24 hours in a or ICU, with serial assessments for complications like or excessive bleeding, while the neonate receives specialized monitoring in the NICU tailored to the congenital condition.

Long-term Monitoring

Following the EXIT procedure, neonates are enrolled in structured long-term follow-up programs to monitor airway integrity, respiratory function, and developmental milestones, particularly in cases of congenital high airway obstruction syndrome (CHAOS) or cervical masses. Serial imaging, including computed tomography (CT) or magnetic resonance imaging (MRI), is routinely performed to detect and track any residual masses post-resection, with intervals adjusted based on findings—such as every 3 months initially if residual tissue is present, extending to 6 months if none is detected. Ear, nose, and throat () evaluations by pediatric otolaryngologists are conducted regularly to assess airway patency, often involving or , and to plan reconstructive interventions like laryngotracheoplasty, which may be deferred until after 24 months to allow airway maturation. Developmental assessments, utilizing standardized tools such as the Bayley Scales of Infant and Toddler Development, occur at key intervals like 6, 12, and 24 months to evaluate cognitive, motor, and language progress, with particular attention to potential hypoxic brain injury via brain ultrasonography. Maternal long-term monitoring emphasizes recovery from the cesarean-like delivery and addresses needs. Routine wound checks are integrated into postpartum visits to monitor for or dehiscence, though rates remain low with prophylactic antibiotics. Psychological support, including counseling and , is provided to mitigate the emotional impact of the high-risk and potential neonatal complications. Contraception counseling is offered during follow-up if future pregnancies are considered, given the elevated risks associated with prior fetal interventions, though subsequent gestations have shown favorable outcomes in reported series. Care is coordinated through multidisciplinary clinics at specialized fetal care centers, involving neonatologists, pulmonologists, and developmental specialists for ongoing growth tracking via anthropometric measurements and nutritional assessments. For survivors, targeted interventions such as speech therapy are implemented to address expressive language delays and challenges, often linked to prolonged tracheostomy use. This integrated approach ensures holistic surveillance, with respiratory function evaluated through periodic pulmonary function tests and oxygenation monitoring. Monitoring typically spans at least 1-2 years, extending to 5 years or longer as needed, with a primary focus on neurodevelopmental milestones and sustained respiratory stability; follow-up durations in cases have ranged from 5 to 76 months in clinical series. These practices align with American College of Obstetricians and Gynecologists (ACOG) recommendations for , which advocate multidisciplinary oversight and systematic data collection for both maternal and neonatal outcomes to optimize long-term health.

Risks and Complications

Maternal Complications

The EXIT procedure, while life-saving for the , carries specific risks to the mother primarily due to the need for partial uterine incision with preservation of placental circulation, prolonged operative time, and deep . These factors increase the likelihood of certain adverse events compared to standard cesarean deliveries, though overall maternal morbidity remains low when performed by experienced teams. Hemorrhage is the most immediate and serious maternal complication, often resulting from the required to access the while maintaining uteroplacental blood flow. Under general , mean estimated blood loss is approximately 1,100-1,200 mL, with about 8% of mothers requiring . This elevated risk stems from the deliberate avoidance of complete during the procedure, which can lead to postpartum hemorrhage due to following delivery. Anesthetic agents, particularly volatile inhalational anesthetics like used for uterine relaxation, contribute to this by exacerbating atony and associated . , occurring in up to 65% of cases under general , is commonly managed with vasopressors but can further complicate hemodynamic stability. Infection risks are heightened by the extended duration of the procedure, which averages 90-120 minutes and increases exposure to . have been reported in up to 15% of cases historically, significantly higher than the 2% rate seen in elective cesareans; however, recent studies show rates as low as 0%. risk is also potentially elevated due to the prolonged operative time and manipulation of the , with historical rates up to 15% (comparable to 10% in standard cesareans), though modern series report 0% with prophylactic measures. Other notable complications include , for which prophylaxis is routinely administered postoperatively to mitigate the risk associated with immobility and surgical stress. Psychological impacts, such as postpartum (PTSD), can occur in women undergoing high-risk deliveries like EXIT, influenced by the procedure's intensity and uncertainty, with prevalence in emergency cesareans ranging up to 40%. Mitigation strategies focus on preoperative preparation and intraoperative vigilance. Blood banking is performed in advance to ensure availability for potential transfusions, given the hemorrhage risk. Extended prophylaxis, typically with intravenous cephalosporins, is administered to reduce rates from the prolonged exposure.

Fetal and Neonatal Complications

The EXIT procedure, while designed to mitigate immediate life-threatening risks to the fetus, carries specific complications for the fetus and neonate, primarily related to airway management, cardiac function, and postnatal adaptation. Airway failure remains a critical concern, occurring when initial securing of the fetal airway proves inadequate, necessitating emergent tracheostomy in approximately 16% of cases in experienced series; for instance, in a cohort of 31 procedures, five neonates required tracheostomy due to persistent obstruction from neck masses. In cases of congenital high airway obstruction syndrome (CHAOS), which increases overall procedural risks, long-term tracheostomy dependence is common, as seen in multiple reported infants who remained ventilator-supported post-delivery. Fetal cardiac complications, such as bradycardia or dysfunction, can arise from mass compression on vital structures, with continuous monitoring via fetal echocardiography essential to detect issues like intermittent bradycardia rates as low as 88 beats per minute during the procedure. Additional fetal risks include effects from delivery often at 35 weeks or later, which may contribute to transient respiratory immaturity even in near-term gestations. When the EXIT procedure transitions to (ECMO) for severe , neonates face ECMO-related , increasing bleeding risks during cannula placement. Incomplete resolution of the underlying , such as persistent airway distortion from unresected masses, can prolong recovery and necessitate further interventions. Neonatally, respiratory distress affects a substantial proportion of cases, with overall adverse events—including difficulties—reported in up to 29% of cases across systematic reviews of fetal interventions. risks from or during the procedure add to morbidity, though specific incidence varies by case complexity. Overall, fetal and neonatal morbidity ranges from 20% to 30%, encompassing these airway, cardiac, and respiratory issues, while mortality is less than 5% in high-volume centers, as evidenced by a single procedure-related death in a series of 31 cases due to insurmountable airway obstruction.

Outcomes and Prognosis

Success Rates and Statistics

The EXIT procedure has achieved neonatal rates of 94% to 100% in cases of airway obstruction due to neck masses at specialized centers, with fetal mortality rates below 3%. In contrast, without EXIT for conditions such as congenital is approximately 48%. is typically defined as establishing a stable airway post-delivery while maintaining uteroplacental circulation, minimizing immediate postnatal . Worldwide, the procedure is infrequently performed, with surveys of major centers indicating low volumes at specialized sites. Survival rates are influenced by prenatal factors, with accurate diagnosis via and MRI allowing for optimized planning. A 2020 systematic review of 130 cases demonstrated that significantly reduces the time to secure an airway compared to standard methods, lowering hypoxia-related risks. Enhanced MRI guidance for preoperative assessment supports sustained high success in predicted difficult airways over immediate alone. The procedure outperforms traditional approaches in such scenarios by providing a controlled transition.

Long-term Effects

For neonates surviving the EXIT procedure, particularly those with congenital high airway obstruction syndrome (), long-term airway management often involves tracheostomy placement, with decannulation possible in select cases leading to oral feeding and ventilator independence. In a cohort of four patients treated with EXIT, all survived to follow-up, though only one achieved tracheostomy decannulation. Airway cases carry risks of associated aerodigestive issues, including potential speech delays due to prolonged intubation or tracheostomy effects. Follow-up assessments have noted mild deficits in approximately 31% of survivors. Developmentally, most EXIT survivors demonstrate normal , with age-appropriate cognitive, , and milestones in the majority of cases; mild deficits occur in about 23%. In specifically, tracheostomy dependence persists in a substantial proportion, with one small series showing 75% requiring long-term tracheostomy. Overall, neurodevelopmental outcomes are generally positive, without reports of severe impairments. Maternal long-term effects mirror those of elective cesarean delivery, with no elevated incidence of complications such as uterine hemorrhage or beyond standard risks. Future pregnancies may involve heightened risks related to cesarean scarring, including potential placental abnormalities, though data specific to remain limited. Postpartum psychological support, including counseling, contributes to maternal recovery. The procedure enhances for survivors by facilitating immediate interventions, such as tumor resection or transition, which support subsequent developmental progress. Rare late complications, like iatrogenic tracheal , can arise from airway manipulations but are minimized with refined techniques. Longitudinal data from fetal therapy registries, such as the North American Fetal Therapy Network, underscore these trends, though comprehensive long-term tracking remains sparse due to the procedure's rarity. Ongoing monitoring for developmental effects, as outlined in postoperative protocols, aids in early intervention.

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