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Umbilical cord

The umbilical cord is a flexible, tubular structure that connects the fetus to the placenta in human pregnancy, serving as the primary conduit for fetal circulation by transporting oxygenated blood and nutrients from the placenta to the fetus while returning deoxygenated blood and waste products.^[1] It typically contains two umbilical arteries, which carry deoxygenated fetal blood to the placenta for gas exchange and nutrient replenishment, and a single umbilical vein that conveys oxygenated blood back to the fetus, with these vessels embedded within a protective matrix of Wharton's jelly—a gelatinous connective tissue rich in mucopolysaccharides and collagen that cushions against compression and maintains structural integrity.^[1]^[2] The cord's average length at term is approximately 50 to 60 centimeters, varying with fetal mobility and gestational factors, and it develops from the body stalk by around the 12th week of gestation, enveloped by an outer layer of amniotic epithelium.^[3]^[4] Clinically, the umbilical cord's patency is critical for fetal viability, as interruptions in blood flow—due to factors like hypercoiling, knots, or velamentous insertion—can lead to hypoxia or intrauterine growth restriction, though routine antenatal monitoring via ultrasound assesses vessel integrity and Doppler flow to mitigate risks.^[1] Post-delivery, the cord is clamped and severed, transitioning the newborn to independent pulmonary respiration, with delayed clamping recommended to enhance neonatal iron stores and reduce anemia risk.^[1] Wharton's jelly has garnered interest for its mesenchymal stem cell content, harvested from discarded cords for regenerative therapies, underscoring the cord's dual role in prenatal support and postnatal biomedical applications.^[2]

Anatomy and Development

Gross and Microscopic Structure

The umbilical cord is a cylindrical, flexible structure that connects the fetus to the placenta, with an average length of 50 to 60 cm and diameter of 1 to 2 cm at term.^[1]^[5] It features a smooth external covering of amnion and is filled with Wharton's jelly, a mucoid connective tissue that encases the vascular components and provides structural support.^[1] The cord typically contains two umbilical arteries, which spiral helically around a single umbilical vein, along with remnants of the urachus in some cases.^[1] Microscopically, Wharton's jelly comprises an extracellular matrix rich in mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, interspersed with fibroblasts and myofibroblast-like cells that maintain its gelatinous consistency and protect vessels from compression.^[1]^[6] The umbilical arteries possess thick tunica media layers dominated by smooth muscle fibers and elastic laminae, enabling vasoconstriction, whereas the vein exhibits a thinner wall with intermixed circular, longitudinal, and oblique smooth muscle orientations but lacks valves.^[4]^[1] Both vessel types are lined by simple squamous endothelium and embedded within the avascular, nerve-free Wharton's jelly, which divides into regions of varying matrix density: perivascular (dense), intervascular (organized), and subamnion (loose).^[6]

Embryological Origins

The umbilical cord originates during the third week of embryonic development with the formation of the connecting stalk, a mesenchymal structure that links the caudal aspect of the trilaminar embryonic disc to the chorionic mesoderm of the developing placenta.^[7] This stalk, derived from extraembryonic mesoderm, initially contains the allantois—an endodermal diverticulum extending from the hindgut—and serves as the precursor conduit for vascular elements that will mature into the cord's arteries and vein.^[7]^[8] By the fourth week, embryonic cephalocaudal and lateral folding integrates the connecting stalk with the vitelline duct (remnant of the yolk sac connection) and the umbilical coelom, while the expanding amnion begins to envelop these components.^[8]^[7] Vasculogenesis initiates within the stalk's mesoderm, with paired allantoic arteries arising from the dorsal aortae and an allantoic vein connecting to the sinus venosus; these vessels elongate as the embryo grows.^[7] Concurrently, lateral mesodermal tissue plates proliferate from the allantoic stalk toward the septum transversum, narrowing the stalk and enclosing portions of the extraembryonic coelom to delineate the cord's boundaries.^[9] Amnion expansion between weeks 4 and 8 fully encases the composite structure—now comprising the body stalk, vitelline remnants, and emerging umbilical vessels—isolating it from the chorionic cavity and establishing the definitive umbilical cord by week 7.^[8]^[7] The two umbilical arteries, carrying deoxygenated fetal blood toward the placenta, and the single umbilical vein, returning oxygenated blood, become embedded in this mesenchymal core, which later differentiates into Wharton's jelly for structural support.^[7] Temporary herniation of midgut loops into the cord occurs around this time but resolves by weeks 10–12 as the abdominal wall closes.^[7] The allantois and vitelline duct typically involute by term, leaving the mature cord as a coiled, gelatinous tube approximately 50–60 cm long.^[7]^[8]

Physiological Functions

Integration with Fetal Circulation

The umbilical cord integrates with the fetal circulatory system by linking the placenta to the fetal vasculature through a single umbilical vein, which conveys oxygenated blood toward the fetus, and two umbilical arteries, which return deoxygenated blood to the placenta. This arrangement enables efficient gas exchange, nutrient delivery, and waste removal, as the placenta functions as the primary respiratory and excretory organ during intrauterine life. The vein carries blood with 70-80% oxygen saturation from the placental chorionic villi, while the arteries transport blood at approximately 40% saturation.^[10] The umbilical vein penetrates the fetal abdomen at the umbilicus and extends cephalad to the porta hepatis, where it divides into branches supplying the liver. A substantial portion of this flow—directed primarily to prioritize systemic oxygenation—bypasses the hepatic sinusoids via the ductus venosus, a narrow shunt connecting the umbilical vein directly to the inferior vena cava (IVC). This venous return then mixes with less oxygenated blood in the IVC before entering the right atrium, where streaming patterns and pressure gradients favor shunting across the foramen ovale into the left atrium for distribution to the brain and myocardium via the ascending aorta. The degree of ductus venosus shunting varies dynamically with fetal hepatic resistance and oxygenation demands, ensuring hepatic perfusion receives the remainder of umbilical venous inflow.^[11]^[10]^[1] The paired umbilical arteries originate from the anterior divisions of the internal iliac arteries within the fetal pelvis, receiving deoxygenated blood from the descending aorta distal to the ductus arteriosus. These vessels course anteriorly around the urinary bladder before converging into the umbilical cord, where they maintain separate lumens protected by Wharton's jelly. Near the placental insertion, the arteries interconnect via the Hyrtl anastomosis, a low-resistance loop that equalizes flow and pressure between the two vessels to optimize placental perfusion. This arterial outflow represents a major fraction of fetal cardiac output—up to 30-40% in late gestation—facilitating the expulsion of carbon dioxide and metabolic wastes into maternal circulation for elimination.^[1]^[10]

Nutrient, Oxygen, and Waste Transport

The umbilical cord serves as the primary conduit for bidirectional blood flow between the fetus and placenta, facilitating the exchange of oxygen, nutrients, and waste products essential for fetal survival. It contains two umbilical arteries, which transport deoxygenated fetal blood laden with carbon dioxide and metabolic wastes from the fetus to the placenta, and a single umbilical vein, which carries oxygenated blood enriched with nutrients from the placenta to the fetus. This vascular arrangement ensures efficient materno-fetal transfer without direct mixing of maternal and fetal circulations, as diffusion and active transport occur across the placental villi.^[1]^[7] Oxygen transport primarily occurs via the umbilical vein, where blood exhibits a partial pressure of oxygen (PO2) of approximately 30-35 mmHg, sufficient to meet fetal demands despite being lower than adult arterial levels, due to the fetus's higher hemoglobin affinity for oxygen and adaptations like fetal hemoglobin (HbF). Nutrients such as glucose, amino acids, fatty acids, and vitamins are delivered in the oxygenated venous blood, with placental mechanisms concentrating these against gradients via specific transporters (e.g., GLUT1 for glucose). Waste elimination, including carbon dioxide (PCO2 around 45-50 mmHg in arterial blood) and urea, proceeds through the umbilical arteries to the placenta, where countercurrent exchange with maternal blood removes them via diffusion or maternal metabolism.^[10]^[12]^[10] Blood flow dynamics support this transport: umbilical venous flow increases from about 100 mL/min near term, comprising roughly 40% of fetal cardiac output directed preferentially to the fetal liver and systemic circulation via the ductus venosus shunt. Umbilical arterial flow, roughly twice that of the vein due to higher resistance, returns deoxygenated blood for reoxygenation. Disruptions in flow, such as cord compression, can impair oxygen delivery and waste clearance, underscoring the cord's role in maintaining fetal homeostasis through high-volume, low-resistance placental perfusion.^[1]^[13]

Postnatal Transitions

Hemodynamic Changes After Delivery

Clamping the umbilical cord after delivery abruptly terminates the low-resistance placental circulation, which in the fetus parallels the systemic circuit and supplies approximately 40-50% of the combined ventricular output via the umbilical vein.^[10] This removal increases systemic vascular resistance (SVR) instantaneously, as the placenta no longer shunts blood away from the high-resistance pulmonary circuit.^[14] Venous return to the heart decreases by 30-50%, reducing preload and potentially compromising left ventricular output in the initial moments post-clamping.^[14] Concurrently, the first breaths expand the lungs, decreasing pulmonary vascular resistance (PVR) and redistributing blood flow to the pulmonary circulation, which rises from less than 10% of cardiac output in the fetus to nearly 100% in the neonate.^[10] These shifts impose an acute rise in left ventricular afterload due to elevated SVR, while the right ventricle faces reduced afterload from falling PVR.^[15] In term infants, cardiac output initially relies on right-to-left shunting through the ductus arteriosus and foramen ovale, but as pulmonary venous return increases, left ventricular preload rises, facilitating closure of these shunts.^[14] Immediate cord clamping before lung aeration can exacerbate hemodynamic instability, including transient bradycardia and hypotension, by limiting sustained placental gas exchange support during the vulnerable transition phase.^[16] Studies indicate that such early clamping reduces cerebral and pulmonary blood flow measures compared to delayed approaches, highlighting the cord's transient role in buffering circulatory demands.^[17] Post-clamping, the umbilical vessels undergo vasospasm triggered by exposure to cooler ambient temperature, higher oxygen tension, and mechanical stimuli, further sealing off residual flow.^[10] This facilitates the neonate's adaptation to independent oxygenation, with mean arterial pressure stabilizing within minutes as pulmonary blood flow establishes effective gas exchange.^[18] In preterm infants, these changes are more pronounced, often leading to greater fluctuations in heart rate and cardiac output, underscoring the need for physiological timing to mitigate risks like intraventricular hemorrhage.^[19] Overall, the hemodynamic transition reflects a causal sequence where cord severance compels rapid cardiac remodeling, prioritizing pulmonary over placental dependency.^[14]

Severance and Initial Management

Following umbilical cord clamping, the cord is severed between two clamps using sterile scissors, with the proximal clamp positioned 1 to 2 centimeters from the infant's abdominal wall to minimize stump length and reduce infection risk.^[20]^[21] The distal clamp secures the placental end, preventing maternal blood loss, while the proximal clamp occludes the vessels to halt fetal bleeding from the three umbilical structures: two arteries and one vein.^[1] The resulting umbilical stump, typically 2 to 3 centimeters long, remains attached to the neonate and is secured by a plastic clamp that remains in place until natural separation occurs, usually between 5 and 15 days postpartum as the stump dries, necroses, and detaches via enzymatic degradation at Wharton's jelly remnants.^[1]^[21] Initial management prioritizes infection prevention through hygiene: caregivers must perform hand hygiene before handling the stump, keep the area clean and dry by exposing it to air during diaper changes and baths, and avoid submerging in water until separation.^[22]^[23] Contemporary guidelines from institutions like the Mayo Clinic and Cleveland Clinic advise against routine use of antiseptics such as rubbing alcohol, citing evidence that it delays separation without reducing infection rates, potentially increasing omphalitis risk in low-resource settings where dry cord care alone has proven superior.^[22]^[23]^[24] If soiled, the stump should be gently cleaned with plain water and allowed to air dry, without application of creams, powders, or tight dressings that trap moisture.^[25]^[26] Parents are instructed to monitor for omphalitis indicators, including foul-smelling discharge, pus, erythema extending beyond the stump base, or fever, prompting immediate medical evaluation, as untreated infection can lead to sepsis with mortality rates up to 10-20% in severe cases.^[1]^[24] The clamp is removed once the stump sloughs off, revealing a healed umbilicus, though in rare delayed separation beyond three weeks, further assessment for underlying conditions like immunodeficiency is warranted.^[1]

Clinical Interventions

Cord Blood Collection and Analysis

Umbilical cord blood collection for analysis typically occurs immediately after delivery to evaluate the neonate's metabolic and acid-base status. For blood gas analysis, a double clamp is applied to a 10-20 cm segment of the umbilical cord post-delivery, isolating arterial and venous samples; the artery, identifiable by its thicker, spiraled walls, reflects fetal status, while the vein indicates placental transfer.^[27] Samples of 1-2 mL are aspirated into pre-heparinized syringes, placed on ice, and analyzed within 60 minutes to ensure reliability of pH, partial pressure of oxygen (pO2), and partial pressure of carbon dioxide (pCO2), though lactate values degrade after 20 minutes.^[27] This procedure poses no risk to the mother or infant and is recommended for high-risk deliveries, such as those with category III fetal heart rate tracings.^[27] Analysis employs blood gas analyzers to measure key parameters: arterial pH ranges from 7.24 to 7.27 in term infants, with venous pH from 7.32 to 7.34; arterial pO2 averages 31.5 mmHg and venous 43.5 mmHg; base excess is -5.6 to -2.7 mEq/L arterially.^[27] 00537-3/fulltext) Pathological acidosis is defined by arterial pH below 7.00 or base deficit exceeding 12 mEq/L, often signaling intrapartum hypoxia.^[27] These values provide an objective assessment of fetal response to labor, aiding in diagnosing conditions like metabolic acidosis and informing neonatal resuscitation; for instance, pH under 7.00 combined with Apgar scores of 5 or less at five minutes predicts neonatal encephalopathy with high specificity.^[27] ^[28] Postnatal cord blood sampling extends collection for diagnostic tests beyond gases, including complete blood counts, blood cultures, typing with direct antiglobulin testing, newborn screening, and coagulation studies, achievable in approximately 95% of cases.^[29] Performed via phlebotomy from a clamped cord segment or placental vessels within 10-30 minutes post-delivery, it minimizes neonatal blood loss (reducing from 7.5 ± 5.2 mL/kg to 1.5 ± 2.3 mL/kg in the first 24 hours), avoids procedural pain, and yields larger volumes for cultures, enhancing sensitivity over heel sticks or venipuncture.^[29] The American Academy of Pediatrics, in its June 2025 clinical report, endorses cord blood as the preferred initial sampling site for all neonates requiring admission labs, particularly in very low birth weight infants, where it correlates with higher hemoglobin levels and reduced transfusion needs.^[29] For therapeutic applications, collection targets the umbilical vein for hematopoietic stem cell harvesting, using a needle to draw 40-150 mL into a sterile bag after cord clamping but before placental expulsion, followed by processing to assess total nucleated cells, CD34+ progenitors, and viability via flow cytometry and colony-forming assays.^[30] This yields empirical data on engraftment potential, though routine analysis prioritizes diagnostic utility over banking volumes.^[31]

Catheterization and Therapeutic Uses

Umbilical vein catheterization (UVC) provides central venous access in neonates, particularly those requiring urgent resuscitation or unable to tolerate peripheral intravenous lines. The primary therapeutic use involves administering total parenteral nutrition (TPN), medications such as prostaglandins for ductus-dependent congenital heart disease, and blood products including exchange transfusions for hyperbilirubinemia.^[32]^[33] UVCs also facilitate central venous pressure monitoring and frequent blood sampling in preterm or critically ill infants, supporting hemodynamic stability and metabolic management in the neonatal intensive care unit (NICU).^[34] Guidelines emphasize reserving UVCs for scenarios where peripheral access fails, avoiding routine use for basic fluids to minimize complications like thrombosis or infection.^[35] Umbilical artery catheterization (UAC) enables arterial access for continuous blood pressure monitoring and serial arterial blood gas analysis, critical for managing respiratory distress or shock in newborns. Therapeutically, UACs allow infusion of vasoactive drugs, such as dopamine for hypotension, and high-dose amino acids to support protein accretion in extremely low birth weight infants.^[36]^[37] They also permit frequent blood sampling without repeated percutaneous punctures, reducing procedural stress in unstable patients, and can deliver blood products or fluids when venous access is compromised.^[38] Placement is typically limited to the first week of life due to arterial constriction postnatally, with low-position catheters preferred for short-term use to avoid renal or mesenteric vessel occlusion.^[39] Both UVC and UAC are integral to NICU protocols for preterm infants under 1 kg, using 2.5 Fr catheters, or larger infants with 3.5 Fr, to optimize outcomes in conditions like persistent pulmonary hypertension or sepsis.^[40] Evidence from standardized guidelines supports early removal—ideally within 7 days for UACs—to reduce infection risk, with studies showing decreased overuse through protocol adherence correlates with lower central line-associated bloodstream infections.^[41]^[42] Therapeutic efficacy relies on radiographic confirmation of position to prevent malposition-related ischemia, ensuring safe delivery of interventions that sustain neonatal viability.^[43]

Abnormalities and Risks

Structural Variants

![Cross section of the umbilical cord showing two arteries and one vein][float-right] The umbilical cord normally consists of two umbilical arteries and one umbilical vein surrounded by Wharton's jelly, a gelatinous substance providing structural support and cushioning.^[44] Structural variants primarily involve deviations in vascular configuration or insertion site, which can compromise fetal circulation and are detectable via prenatal ultrasound or postmortem examination.^[45] Single umbilical artery (SUA), the most common vascular anomaly, features only one artery alongside the vein, with a prevalence of 0.4-1% in singleton pregnancies.^[46] This variant arises from atrophy of one artery or persistence of an allantoic artery and is associated with congenital malformations in 11-60% of cases, particularly gastrointestinal atresias, cardiac defects, and renal anomalies, as well as increased risks of intrauterine growth restriction and chromosomal abnormalities.^[47]^[48] Isolated SUA, without other anomalies, carries a lower but still elevated risk of adverse outcomes, necessitating serial fetal monitoring.^[49] Abnormal cord insertion variants include marginal and velamentous types, differing from the typical central or eccentric attachment to the placental chorionic plate. Marginal insertion occurs when the cord attaches within 2 cm of the placental margin, potentially restricting blood flow due to mechanical compression or inadequate placental sharing.^[50] It is linked to higher rates of preterm birth, low birth weight, and emergency cesarean sections, though outcomes vary with gestational monitoring.^[51] Velamentous insertion, where vessels course unprotected through the fetal membranes before reaching the placenta, affects approximately 1% of pregnancies and heightens risks of vessel rupture (vasa previa), fetal hypoxia, stillbirth, and postpartum hemorrhage.^[52]^[53] These insertion anomalies often correlate with placental underdevelopment and are more prevalent in in vitro fertilization pregnancies.^[54] Less frequent structural variants encompass variations in vessel number, such as pseudotwins (four vessels from monozygotic twinning) or supernumerary vessels, and morphological changes like cysts or strictures within Wharton's jelly, which may indicate underlying connective tissue disruptions but rarely cause isolated complications without associated anomalies.^[45] Prenatal detection of these variants via Doppler ultrasound or MRI aids in risk stratification, though their causal role in outcomes requires distinguishing from confounding fetal or placental pathologies.^[55]

Pathophysiological Complications

Pathophysiological complications of the umbilical cord arise primarily from structural anomalies that impair vascular patency, leading to fetal hypoxia, acidosis, and elevated risks of intrauterine fetal demise (IUFD) or neonatal morbidity. These abnormalities account for approximately 10-19% of stillbirth cases, even under rigorous diagnostic criteria.^[56] Compromised blood flow results from mechanical compression, torsion, or vessel fragility, disrupting the exchange of oxygen, nutrients, and waste between maternal and fetal circulations.^[57] Abnormal umbilical coiling, quantified by the coiling index (UCI; coils per cm), exemplifies flow-related pathophysiology. Hypocoiling (UCI below the 10th percentile, typically <0.26 coils/cm) correlates with IUFD (odds ratio 3.4), fetal anomalies such as trisomies (odds ratio 5.8), and velamentous insertion, likely reflecting underlying developmental vascular defects rather than direct compression.^[58] Hypercoiling (UCI above the 90th percentile, >0.46 coils/cm) associates with fetal acidosis (odds ratio 2.9), asphyxia (odds ratio 4.2), small-for-gestational-age infants (odds ratio 2.1), and single umbilical artery, potentially due to increased torsional forces exacerbating vascular resistance and ischemia.^[58]^[59] True umbilical cord knots, occurring in about 1.2% of pregnancies, form during fetal movement in a long cord (>70 cm) and tighten during labor, compressing arteries and veins to cause acute hypoxia and stillbirth (odds ratio 3.96).^[59] Associated factors include male fetal sex and maternal diabetes, with outcomes including intrauterine growth restriction (IUGR), preterm birth, and low Apgar scores.^[59] Cord strictures, characterized by Wharton’s jelly atrophy and segmental hypoplasia, induce torsion and luminal occlusion, precipitating hypoxia and IUFD through unrelieved vascular blockade.^[59] Umbilical cord prolapse, with an incidence of 1.4-6.2 per 1000 births, involves the cord preceding the presenting part into the birth canal, resulting in sustained compression against the cervix or fetal head, vasoconstriction, and profound bradycardia.^[60] Risk factors encompass malpresentation, polyhydramnios, and preterm labor; fetal mortality exceeds 10% without immediate cesarean delivery, with premature neonates facing doubled risk due to immature compensatory mechanisms.^[60] Velamentous cord insertion and vasa previa expose fetal vessels to rupture risk, as unprotected arteries traverse membranes over the cervical os. In vasa previa (incidence 1:2500-1:5000), membrane rupture triggers rapid exsanguination, yielding 56-60% fetal mortality if undiagnosed, versus near-zero with prenatal detection and planned cesarean.^[61] Velamentous insertion similarly heightens vessel vulnerability, linking to fetal distress in 57.8% of cases via hemorrhage or compression.^[57] Single umbilical artery (SUA), seen in 0.5-1% of pregnancies, stems from early embryonic vascular atrophy or agenesis, reducing redundancy and associating with congenital anomalies (odds ratio 6.77), chromosomal aberrations (odds ratio 15.35), IUGR, and IUFD even when isolated.^[59]^[62] Pathophysiologically, diminished vessel count impairs flow reserve, exacerbating hypoxia under stress, with isolated SUA still conferring risks of low birth weight and perinatal death.^[63]

Debates and Evidence-Based Practices

Timing of Cord Clamping: Early vs. Delayed

Delayed cord clamping refers to waiting at least 30–60 seconds after birth before clamping the umbilical cord, allowing placental transfusion of approximately 20–30% additional blood volume to the neonate, whereas early cord clamping occurs within the first 30 seconds.^[64]^[65] This physiological process enhances neonatal circulating blood volume, hemoglobin levels, and iron stores, as the placenta retains significant residual blood post-delivery that would otherwise be lost if clamped prematurely.^[66] Systematic reviews indicate that in term infants, delayed clamping increases mean hemoglobin by 0.6–2.2 g/dL at 24–48 hours and ferritin levels by 5–10 μg/L at 1–2 months, reducing iron deficiency anemia risk by up to 60% at 4–6 months without affecting long-term neurodevelopment.^[67]^[64] In preterm infants born before 37 weeks gestation, evidence from randomized trials and meta-analyses shows delayed clamping (typically 30–60 seconds) reduces in-hospital mortality by 30–50% compared to immediate clamping, with high-certainty data from over 5,000 participants confirming lower rates of intraventricular hemorrhage and necrotizing enterocolitis.^[68]^[66] However, a 2017 multicenter trial found no reduction in the composite outcome of death or major morbidity at 36 weeks, though subsequent analyses and updates emphasize mortality benefits outweighing neutral effects on other morbidities.^[69] For preterm twins, delayed clamping similarly decreases mortality without increasing respiratory or infectious complications.^[70] These outcomes stem causally from improved hemodynamic stability and oxygen-carrying capacity, mitigating hypovolemia common in preterm deliveries.^[68] Potential risks of delayed clamping include asymptomatic polycythemia (hematocrit >65%), occurring in 3–4 times more cases than early clamping (relative risk 3.82), and transient hyperbilirubinemia leading to phototherapy in 1–2% additional infants, though recent data show no clinically significant increase in severe jaundice or kernicterus.^[67]^[64] No associations exist with increased maternal hemorrhage, infection, or long-term adverse effects, and benefits persist even in cesarean deliveries.^[64] In resuscitation scenarios requiring immediate intervention, cord milking may serve as an alternative to expedite transfusion.^[71] Current guidelines reflect this evidence: the World Health Organization recommends delaying clamping until at least 1 minute or until cord pulsations cease in both term and preterm infants not needing resuscitation, while the American College of Obstetricians and Gynecologists (ACOG) endorses at least 30–60 seconds for term infants and 60 seconds for preterm neonates as of 2025 updates, prioritizing placental transfusion unless contraindicated.^[65]^[64]^[72] Early clamping, once routine to facilitate rapid separation, is now discouraged except in cases of fetal distress or maternal hemorrhage, as empirical data demonstrate net neonatal gains from delay.^[64]^[73]

Cord Blood Banking: Efficacy and Ethics

Cord blood banking involves the collection, processing, and cryopreservation of hematopoietic stem cells from umbilical cord blood post-delivery for potential future therapeutic use. These stem cells can treat over 80 hematological and immunological disorders, including leukemias, lymphomas, and sickle cell anemia, primarily through allogeneic transplantation where donor cells replace diseased marrow. Over 40,000 cord blood transplants have been performed worldwide as of 2021, demonstrating established efficacy in pediatric and adult settings with outcomes comparable to bone marrow or peripheral blood stem cell transplants.^[74] Efficacy for autologous use—employing a child's own stored cord blood—is limited by several factors. The volume of collectible cord blood (typically 50-200 mL) suffices mainly for pediatric recipients under 40 kg, restricting adult applicability unless multiple units are combined, which increases costs and complexity. Autologous transplants are contraindicated for genetic or malignancy-related conditions, as the stored cells harbor the same defects; for instance, in leukemia, remission requires disease eradication prior to reinfusion, negating autologous utility. Empirical data indicate low utilization: private banks report release rates below 0.1% of stored units, with public banks achieving 30-fold higher usage due to broader matching pools. Probability estimates for a healthy child needing their own banked cord blood range from 1 in 2,700 to 0.04% within the first 20 years, underscoring its role more as biological insurance than routine intervention.^[75]^[76]^[77] Emerging applications in regenerative medicine, such as cerebral palsy trials, show mixed results; a 2025 systematic review of umbilical cord-derived stem cells reported safety but inconsistent efficacy improvements, with better outcomes in children under 5 years and milder cases (GMFCS levels 1-3). Cord blood transplants exhibit advantages like reduced graft-versus-host disease incidence (10-20% lower than bone marrow) due to immunological naivety of neonatal cells, yet slower engraftment (median 21-28 days vs. 14-21 for bone marrow) elevates infection risks. Overall survival post-transplant approximates 50-70% at 2-3 years, influenced by disease stage, HLA matching, and cell dose, but double-unit cord blood strategies improve leukemia-free survival to 62% at 2 years versus 42% for single units.^[78]^[79]^[80] Ethically, private cord blood banking raises concerns over commercialization and informed consent, as for-profit entities market speculative future therapies despite scant evidence for autologous efficacy, potentially exploiting parental anxiety. Costs exceed $1,500 initial processing plus $100-300 annual storage, yielding poor cost-effectiveness at $1.37 million per life-year gained, per a 2009 analysis reaffirmed in subsequent reviews. Physicians must disclose affiliations with banks to mitigate conflicts, as recommended by the American Medical Association, emphasizing that routine private banking lacks endorsement from major hematology societies absent family risk factors like prior transplants.^[81]^[82]^[83] Public donation, conversely, enhances equitable access and societal utility, with units available via registries like those of the National Marrow Donor Program, though it forgoes personal reservation. Ethical challenges include equitable banking access across socioeconomic strata and ensuring voluntary, non-coerced consent amid marketing pressures; studies highlight how private promotions overstate benefits, influencing decisions without probabilistic context. Hybrid models blending public-private elements have been proposed to balance individual security with communal benefit, but regulatory oversight remains inconsistent globally.^[84]^[85]

Alternative Approaches like Milking and Non-Severance

Umbilical cord milking involves manually stripping or compressing the cord from the placental end toward the infant to transfer residual fetal blood into the neonate prior to or during clamping. This technique aims to augment the infant's blood volume by approximately 20-30%, particularly in scenarios where delayed cord clamping is not feasible, such as nonvigorous infants requiring immediate resuscitation. Randomized controlled trials have demonstrated that milking improves early hemoglobin levels and reduces the need for red blood cell transfusions in preterm infants, with one meta-analysis indicating a reduction in mortality among extremely preterm neonates. In term and near-term infants, milking has been associated with sustained improvements in iron status at 6 weeks of age, without significant adverse hemodynamic effects in the initial postnatal period. However, evidence from large trials like PREMOD2 reveals an elevated risk of severe intraventricular hemorrhage in extremely preterm infants (born at 23-26 weeks gestation) undergoing milking compared to delayed clamping, prompting caution in this subgroup. Overall, systematic reviews highlight benefits in blood volume expansion and short-term oxygenation but underscore the need for further hemodynamic studies, as rapid volume shifts may contribute to risks like polycythemia or hypertension in vulnerable neonates. Non-severance of the umbilical cord, often termed lotus birth, entails leaving the cord intact post-delivery, allowing natural detachment after several days to weeks, with the placenta kept attached and sometimes ritually preserved. Proponents claim spiritual or physiological benefits, such as continued nutrient transfer or emotional bonding, but no peer-reviewed studies substantiate improved neonatal outcomes or placental-fetal exchange after birth, as circulation ceases with delivery. Case series and observational reports document heightened infection risks, including omphalitis and potential sepsis, due to the necrotic placenta serving as a bacterial reservoir, with documented instances of neonatal hepatitis and jaundice linked to this practice. Professional bodies, including the Royal College of Obstetricians and Gynaecologists, advise against it owing to absent evidence of efficacy and documented infectious complications, such as in reported cases where delayed separation exceeded 10 days and correlated with maternal or neonatal morbidity. While rare cluster-randomized data on intact cord resuscitation show feasibility without immediate sepsis, long-term non-severance lacks endorsement in evidence-based guidelines, emphasizing empirical risks over anecdotal claims.

Emerging Research and Applications

Regenerative Potential of Cord-Derived Stem Cells

Umbilical cord-derived mesenchymal stem cells (UC-MSCs), primarily isolated from Wharton's jelly within the cord's connective tissue, exhibit multipotent differentiation potential into lineages such as osteocytes, chondrocytes, adipocytes, and myocytes, supporting their role in tissue repair.^[86] These cells demonstrate robust proliferative capacity, with population doubling times shorter than those of bone marrow-derived MSCs (BM-MSCs), enabling scalable expansion for therapeutic use without ethical concerns associated with embryonic sources.^[87] Additionally, UC-MSCs secrete paracrine factors including growth factors and cytokines that modulate inflammation and promote angiogenesis, contributing to regenerative effects beyond direct differentiation.^[88] In preclinical models, UC-MSCs have shown efficacy in regenerating damaged tissues, such as improving cartilage repair in osteoarthritis by enhancing extracellular matrix production and reducing inflammatory markers like TNF-α.^[86] For myocardial infarction, intravenous administration of UC-MSCs in animal studies led to improved left ventricular ejection fraction through paracrine-mediated cardiac remodeling and reduced fibrosis, outperforming BM-MSCs in functional recovery metrics.^[89] Their low immunogenicity and homing ability to injury sites further enhance therapeutic potential, as evidenced by superior migration toward inflamed tissues compared to adult-derived MSCs.^[90] Clinical trials have advanced UC-MSC applications, with phase I/II studies demonstrating safety and preliminary efficacy in conditions like type 1 diabetes, where Wharton's jelly-derived cells preserved β-cell function and reduced autoimmunity markers in patients followed for up to 12 months.^[91] In knee osteoarthritis, intra-articular injections of umbilical cord blood MSCs improved pain scores and joint function in randomized trials, with regenerative effects attributed to chondrogenic differentiation and anti-inflammatory modulation persisting at 24-month follow-ups.^[92] For cerebral palsy, ongoing trials such as NCT06143527 evaluate intravenous UC-MSC infusions for neuroregeneration, reporting tolerable adverse events and hints of motor improvement in early cohorts.^[93] Despite promising data, UC-MSC therapies remain investigational, with randomized controlled trials needed to confirm long-term efficacy against placebo effects and standardize dosing; meta-analyses indicate consistent safety but variable outcomes influenced by cell potency and patient heterogeneity.^[94] Advantages over BM-MSCs include noninvasive collection yielding higher cell yields (up to 10-fold) and reduced senescence, minimizing donor site morbidity while supporting off-the-shelf allogeneic use.^[95]

Biomarkers and Precision Neonatal Care

Umbilical cord blood serves as a rich source for biomarkers that enable early risk stratification in neonates, particularly for preterm infants prone to complications like early-onset sepsis (EOS). Proteomic analysis of cord blood has identified proteins such as serum amyloid A1 (SAA1), lipopolysaccharide-binding protein (LBP), C-reactive protein (CRP), leucine-rich alpha-2-glycoprotein 1 (LRG1), and serpin family A member 3 (SERPINA3) as indicators of EOS, with these acute-phase reactants elevated in affected infants.^[96] A diagnostic model incorporating these biomarkers distinguishes EOS cases from non-cases, potentially guiding targeted antibiotic use and reducing overtreatment in low-risk neonates.^[96] Such approaches align with precision neonatal care by providing birth-time data to personalize interventions, sparing unnecessary exposures that contribute to antibiotic resistance.^[97] Procalcitonin (PCT) levels in umbilical cord blood offer another validated biomarker for EOS detection, showing elevated concentrations in term and near-term infants with proven or probable infection while remaining low in uninfected risk-factor cases.^[98] Studies report PCT's diagnostic accuracy, with sensitivity and specificity supporting its use to refine sepsis protocols, though thresholds vary by gestational age.^[98] Interleukin-6 (IL-6) in cord blood similarly predicts EOS in preterm neonates, with levels correlating to infection severity and aiding in distinguishing inflammatory states from sterile conditions.^[99] These markers facilitate causal inference in neonatal pathophysiology, linking intrauterine exposures to postnatal risks without relying on delayed postnatal sampling. Proteomic profiling across gestational ages reveals dynamic changes in cord blood proteins, informing developmental trajectories and complication risks beyond infection, such as prematurity-related morbidity.^[100] For instance, neuro-specific biomarkers like glial fibrillary acidic protein (GFAP), tau, and neurofilament light chain (NFL) are significantly higher in cord blood of newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE), enabling early neuroprotective strategy decisions.^[101] Comprehensive reviews of cord blood and neonatal biomarkers underscore their diagnostic value for conditions including sepsis and asphyxia, though integration into routine care requires validation against clinical outcomes to avoid overinterpretation of isolated elevations.^[102] In precision contexts, these tools shift from uniform protocols to individualized monitoring, prioritizing empirical thresholds over consensus guidelines influenced by institutional biases toward aggressive intervention.^[29]

Comparative Biology

Umbilical Structures in Non-Human Mammals

In placental mammals (Eutheria), the umbilical cord typically comprises two umbilical arteries conveying deoxygenated blood from the fetus to the placenta and a single umbilical vein returning oxygenated, nutrient-rich blood to the fetus, all encased in a protective gelatinous matrix known as Wharton's jelly.^[103] This structure facilitates chorioallantoic placentation, with variations in vessel arrangement, coiling, and length adapting to species-specific gestational demands; for instance, equine umbilical cords measure up to 100 cm or more, reflecting prolonged intrauterine development, while porcine cords exhibit indistinct perivascular demarcation compared to primates.^[104] ^[103] In ruminants such as cattle and sheep, the cord includes the urachus and maintains a similar vascular configuration but integrates with a cotyledonary placenta, where fetal cotyledons attach to maternal caruncles.^[105] Non-placental mammals diverge markedly. Marsupials (Metatheria) possess a transient yolk-sac (choriovitelline) placenta for early nutrition, supplemented briefly by allantoic vessels in some species, but lack a persistent umbilical cord; the underdeveloped neonate detaches early, crawling to the pouch without vascular severance, as maternal investment shifts to lactation post-birth.^[106] Monotremes (Prototheria), the egg-laying mammals including platypuses and echidnas, exhibit no umbilical structures whatsoever, relying instead on yolk reserves within leathery eggs for embryonic sustenance until hatching, bypassing viviparity entirely.^[107] These differences underscore evolutionary adaptations in reproductive strategies, with placental cords enabling extended gestation and marsupial/monotreme systems favoring precocial mobility or external development.^[103]

Additional Contexts

Environmental Toxin Accumulation

The umbilical cord serves as a conduit for environmental toxins from maternal blood to the fetal circulation, resulting in measurable accumulation in cord blood and tissues, which reflects in utero exposure to pollutants originating from air, water, diet, and consumer products.^[108] Studies consistently detect a range of contaminants, including heavy metals, persistent organic pollutants (POPs), and endocrine-disrupting chemicals, with cord blood concentrations typically lower than or equal to maternal levels due to placental transfer dynamics, though bioaccumulation can occur in fetal compartments.^[108] ^[109] Heavy metals such as lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), and antimony (Sb) are routinely identified in umbilical cord blood, often correlating with maternal occupational or environmental exposures; for example, Pb levels in cord blood approximate 85-90% of maternal concentrations, while Cd transfer varies but remains detectable.^[109] ^[110] Prenatal exposure to these metals has been linked to altered DNA methylation patterns in newborns, potentially affecting gene regulation and long-term health outcomes like neurodevelopment.^[111] In a 2025 analysis of cord blood from passive smoker-exposed pregnancies, elevated potentially toxic metals (PTMs) served as biomarkers, with significant associations to inflammatory markers like TNFα for Cr, Ni, As, Cd, Hg, and Pb.^[112] ^[113] Persistent organic pollutants, including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), persist in cord blood despite regulatory bans, as evidenced by a 2024 study in Şanlıurfa, Turkey, which quantified multiple PCB congeners and OCP metabolites across 100 samples, with detection frequencies exceeding 50% for several compounds.^[114] Higher PCB levels in cord blood have been associated with elevated inflammatory cytokines (e.g., TNF-α, IL-6) and oxidative stress markers, suggesting mechanistic pathways for fetal impact.^[115] ^[116] Per- and polyfluoroalkyl substances (PFAS), phthalates, and bisphenols represent emerging concerns, with PFAS detected in 100% of cord blood samples across 40 studies from 2017-2022, underscoring placental permeability and widespread fetal burden from these bioaccumulative compounds.^[117] Phthalates cross the placental barrier, altering fetal metabolome and associating with preterm birth risks, while bisphenol A (BPA) and related phenols show variable transfer rates (8-73% probability of detection in cord relative to maternal blood).^[118] ^[119] ^[108] A 2025 review of endocrine disruptors highlighted associations between prenatal PFAAs, phthalates, and bisphenols in cord blood with prolonged time-to-pregnancy and miscarriage, emphasizing the need for reduced maternal exposure to mitigate transplacental transfer.^[118] Comprehensive early screening of 413 chemicals in 10 U.S. newborn cord blood samples (2004-2005) revealed 287 detections (69%), including 180 known carcinogens and 217 neurotoxins, illustrating the breadth of fetal pollution burden even in industrialized settings.^[120]

Non-Biological Uses of the Term

In engineering and technology, the term "umbilical cord" is applied metaphorically to cables, hoses, or bundled conduits that provide essential supplies such as power, data, fluids, or gases to remote equipment or personnel, analogous to the biological structure's role in sustaining fetal life.^[121] These umbilicals serve as temporary lifelines, often designed for detachment once the connected system becomes self-sufficient.^[122] In aerospace applications, umbilical cables connect launch vehicles to ground support infrastructure on the launch pad, delivering cryogenic fuels, electrical power, instrumentation signals, and purge gases prior to ignition. For instance, the Space Launch System (SLS) mobile launcher employs multiple umbilicals on its tower that retract automatically during liftoff to avoid interference, with systems tested for reliable release under dynamic loads as demonstrated in NASA's 2021 umbilical release trials at Kennedy Space Center.^[122] ^[123] Similarly, during the 1965 Gemini 4 mission, an umbilical tether linked astronaut Ed White to the spacecraft, supplying oxygen and communications during the first U.S. extravehicular activity.^[124] In commercial diving and subsea operations, diver umbilicals bundle breathing gas hoses (typically 3/8-inch bore for air supply), communication lines, and pneumatic hoses for tools, connecting the diver to surface support vessels or diving bells. These assemblies, often 5-part configurations including hot water lines for thermal protection, enable extended surface-supplied dives to depths exceeding 300 meters, with anti-kink designs enhancing safety in entanglement-prone environments.^[121] ^[125] Subsea umbilicals extend this concept to remotely operated vehicles (ROVs) and offshore platforms, transmitting hydraulic power, electrical signals, and fiber optics for control and monitoring in oil and gas extraction since the 1970s.^[121] The terminology underscores the critical, nurturing dependency these connections provide, with failures potentially catastrophic; for example, umbilical severance mechanisms in rocketry must withstand vibrations up to 10g and temperatures from -423°F to 1,200°F.^[126] Such uses highlight engineering adaptations of biological nomenclature for reliability in high-stakes isolation scenarios.^[127]

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Difference between Marsupial, Placental and Monotremes
May 16, 2025 · The baby is attached to the uterus by an umbilical cord, which in ... There are only two species of monotremes, the platypus and echidna.
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Environmental Chemicals in an Urban Population of Pregnant ...
A recent review concluded that chemical concentrations in umbilical cord blood are generally lower than or equal to those in maternal blood, except in the ...
[109]
Organochlorine and heavy metals in newborns - ScienceDirect.com
Umbilical cord blood levels of Pb have been reported to be about 85 to 90% of those of the mother (Lagerkvist et al., 1996). For Cd, different transfer ...
[110]
Heavy Metals in Umbilical Cord Blood: Effects on Epigenetics and ...
This review looks at how exposure to heavy metals during pregnancy can cause changes in the gene regulation by DNAm in newborns, as seen in their umbilical ...
[111]
Heavy Metals in Umbilical Cord Blood: Effects on Epigenetics and ...
Oct 26, 2024 · This review looks at how exposure to heavy metals during pregnancy can cause changes in the gene regulation by DNAm in newborns, as seen in their umbilical ...
[112]
Potentially toxic metals in umbilical cord blood as a biomarker for ...
Jul 1, 2025 · The present study was performed to determine the potentially toxic metals (PTMs) in umbilical cord blood as a biomarker for passive smoker women ...
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Maternal and cord blood potentially toxic elements levels and ...
Jul 15, 2025 · In umbilical cord blood, several PTEs, including Cr, Ni, As, Cd, Hg, and Pb, showed significant positive associations with TNFα levels.
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Exploring the levels of persistent organic pollutants in umbilical cord ...
Jul 25, 2024 · This study aimed to investigate levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in umbilical cord blood from Şanlıurfa mothers ...
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Prenatal exposure to polychlorinated biphenyls is associated with ...
Mar 12, 2025 · We found that higher levels of PCBs in umbilical cord blood are linked to increased markers of inflammation, such as TNF-α, IL-6, IL-8, and TGF- ...
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Prenatal exposure to polychlorinated biphenyls is associated with ...
Mar 12, 2025 · This study is the first to link PCB exposure in umbilical cord blood with increased markers of inflammation and oxidative stress, shedding new light on the ...<|separator|>
[117]
Forever chemicals could expose the human fetus to xenobiotics by ...
It found that toxic forever chemicals were detected in every umbilical cord blood sample across forty studies conducted over the last five years. This ...
[118]
Endocrine disrupting chemicals in maternal and umbilical cord ...
Aug 18, 2025 · Exposure to PFAAs, phthalates and bisphenols has been associated with longer time-to-pregnancy, miscarriage and adverse pregnancy outcomes, ...
[119]
Impact of prenatal phthalate exposure on newborn metabolome and ...
Apr 2, 2025 · It is especially concerning that phthalates can cross the placental barrier and affect normal embryonic and fetal development. Previous research ...
[120]
Body Burden: The Pollution in Newborns
Jul 14, 2005 · Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer in humans or animals, 217 are toxic to the brain and ...
[121]
Understanding Subsea Umbilical Cables - Geospace Technologies
Aug 28, 2020 · Subsea umbilical cables are used in diving, robotics, the military, and some aerospace applications. The subsea cable connects a ship, floating ...
[122]
https://www.nasa.gov/wp-content/uploads/2018/06/fs-2018-02-250-ksc-ml_umbilical_fact_sheet.pdf
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NASA Artemis I Umbilical Release and Retract Test - YouTube
Sep 29, 2021 · Engineers at KSC successfully completed the Umbilical Release and ... Hold Down Release Mechanism - The nuts & bolts that unfold a spacecraft.
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Life Support Umbilical, White, Gemini 4
This tether umbilical cord was used to connect astronaut Ed White to the Gemini 4 capsule during his historic walk in space in June 1965.
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Umbilicals & Hoses in Commercial Diving - iSubC
Jul 21, 2024 · For surface-supplied diving, the umbilical is the primary link between the diver and the surface. It typically includes air supply hoses, ...
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[PDF] Northrop Grumman Umbilical Final Report
This project is important to Northrop Grumman and the aerospace and defense industries because umbilical cables provide many different things, such as ...
[127]
How are umbilical connectors held in place until their intended ...
Apr 29, 2019 · When a rocket is on its launch pad, umbilicals allow the flow of liquids, gases, electric power, and signals to the spacecraft. The umbilical is ...