The first metacarpal bone, also known as the metacarpal of the thumb, is the most lateral and shortest of the five metacarpal bones in the human hand, measuring approximately 47.6 mm in average length.[1] It forms the skeletal foundation of the thumb, extending from the wrist to the base of the proximal phalanx, and is uniquely positioned separate from the other metacarpals to enable independent mobility.[2] This bone is characterized by its robust, medially rotated shaft, which orients the thumb's anterior surface medially and its ulnar border posteriorly, facilitating essential hand functions such as opposition and grasping.[3]Structurally, the first metacarpal consists of a saddle-shaped base, a thick shaft with a longitudinal ridge on its palmar surface, and a relatively flat head.[3] The base articulates proximally with the trapezium carpal bone via the saddle-shaped carpometacarpal (CMC) joint, allowing multiaxial movement including flexion, extension, abduction, adduction, and opposition.[2] Distally, the head forms the metacarpophalangeal (MCP) joint with the base of the thumb's proximal phalanx, supported by two sesamoid bones that enhance stability and motion.[2] Key muscle attachments include the opponens pollicis on the radial border, the radial head of the first dorsal interosseous on the ulnar border, and the abductor pollicis longus at the base,[4] all contributing to the thumb's dexterity.[3]The first metacarpal's mobility is crucial for hand function, enabling precise manipulation and power grip, but it is also prone to injury and pathology.[5] Fractures often require surgical intervention if malrotation occurs, while conditions like thumb carpometacarpal osteoarthritis or rheumatoid arthritis can lead to deformities such as zigzag collapse, significantly impairing daily activities.[2]
Structure
Head
The head of the first metacarpal bone, located at its distal end, exhibits a convex and rounded morphology that is specifically adapted for forming the metacarpophalangeal (MCP) joint with the base of the thumb's proximal phalanx. This shape contributes to the saddle-like configuration of the joint, permitting extensive mobility including flexion, extension, abduction, and adduction essential for thumb opposition and prehensile grip.[6] The convex articular surface faces distally and is broader in the coronal plane compared to the sagittal plane, optimizing contact and load distribution during thumb movements.[3] The palmar aspect of the head includes facets for the two sesamoid bones embedded in the flexor pollicis brevis tendon, which articulate with the head and enhance joint stability and motion.[2]In contrast to the heads of the other metacarpal bones, which possess distinct tubercles or a transverse ridge dividing the articular surfaces into separate facets for the radial and ulnar sides of the proximal phalanges, the first metacarpal head lacks these features. Instead, it presents a uniformly smooth articular surface covering nearly the entire distal aspect, which enhances gliding and rotational freedom at the MCP joint while reducing constraints on motion.[3] This smooth, uninterrupted hyaline cartilage-covered expanse supports the thumb's unique role in fine motor tasks without the compartmentalization seen in the digits.[6]Typical dimensions of the head in adults measure approximately 15.1 mm (±1.9 mm) in the coronal plane and 13.2 mm (±1.7 mm) in the sagittal plane, based on computed tomography analyses of diverse patient cohorts.[7] These measurements reflect the head's relatively robust build relative to the bone's overall shortness, providing structural stability amid high functional demands.Morphological variations in the head shape occur across populations, with some individuals exhibiting a flatter configuration rather than the typical convexity; such flattening has been linked to altered biomechanics and higher susceptibility to first MCP jointosteoarthritis in studies of joint degeneration.[8] These variations, including biplanar or convex subtypes, influence stress distribution and joint stability, though they do not universally impair function.[9]
Shaft
The shaft of the first metacarpal bone forms the elongated middle portion connecting the proximal base to the distal head, exhibiting a triangular cross-section with dorsal, palmar, and medial surfaces. The apex of this triangle is directed palmarly, where the bone is denser to withstand flexor forces, while the dorsal surface is less dense and weakly convex longitudinally. The palmar and medial surfaces are typically concave, creating hollows that accommodate muscle and tendon attachments.[10]This shaft displays a pronounced dorsalcurvature and lateral orientation, rotated approximately 90 degrees medially relative to the other metacarpals, which positions it perpendicular to the palm and enables the thumb's opposability and independent movement. Nutrient foramina, usually numbering one and located in the middle third of the shaft, are present on the palmar (medial) surface to permit entry of the nutrient artery, ensuring vascular supply to the medullary cavity.[3][11]Muscle attachments along the shaft support thumb function: the opponens pollicis attaches to the radial border and adjacent shaft.[3]In adults, the shaft length measures typically 40-50 mm, with an average of 47.6 mm (range 39.2-56.9 mm), exhibiting variations influenced by sex (longer in males) and ethnicity due to differences in overall hand proportions. This length contributes to the bone's overall alignment, continuous with the head and base for stable thumb positioning.[1][2]
Base
The base of the first metacarpal bone represents the proximal end, characterized by its wedge-shaped morphology that anchors the thumb to the carpus and facilitates the formation of the saddle-shaped carpometacarpal joint.[3] This design positions the bone in a more anterior and medially rotated orientation compared to the other metacarpals, enhancing thumb mobility.[12]The articular surface on the base is saddle-shaped, featuring a concavo-convex profile that is concave along the dorsopalmar axis and convex along the mediolateral axis, reciprocally articulating with the trapezium bone to enable multi-axial movements including flexion-extension, abduction-adduction, and opposition.[13] This biconcave-convex configuration provides inherent stability while allowing a wide range of motion essential for thumb function.[14] The base measures approximately 11-12 mm in width, providing anchorage and load-bearing capacity.[7]On the dorsal aspect, a prominent tubercle serves as the primary attachment site for the dorsoradial ligament, reinforcing the joint against excessive translation.[13] Medially and laterally, the base includes small facets: the medial (ulnar) facet contacts the adjacent second metacarpal for limited intermetacarpal stability.[3] These ligamentous reinforcements at the base, including the anterior oblique ligament, further stabilize the carpometacarpal articulation. The abductor pollicis longus inserts on the radial aspect of the base, facilitating abduction. The first dorsal interosseous originates from the ulnar border of the base.[13][15][16]
Development
Ossification
The development of the first metacarpal bone begins with the formation of a cartilaginous model within the embryonic hand plate, derived from mesenchymal condensations around the 7th week of gestation.[17] This hyaline cartilage precursor provides the template for subsequent bone formation through endochondral ossification, a process characteristic of the appendicular skeleton.[18]The primary ossification center emerges in the mid-shaft (diaphysis) of this cartilaginous model during the 8th to 10th intrauterine weeks, initiating intramembranous bone deposition from a single site.[19][20] The first metacarpal ossifies from two centers: a primary center in the shaft in utero and a secondary center at the proximal base postnatally, unlike other metacarpals which have secondary centers at the distal heads. This diaphyseal pattern proceeds via endochondral ossification, where central chondrocytes hypertrophy, secrete alkaline phosphatase, and facilitate matrix calcification, followed by vascular invasion and osteoblast activity to form trabecular bone.[18][21] The secondary ossification center at the base appears around 2-3 years of age. Histologically, the process features zones of hypertrophic chondrocytes that undergo apoptosis, allowing periosteal bone collar formation and the establishment of a primary spongiosa.[18]
Growth and maturation
The first metacarpal bone exhibits longitudinal growth primarily through endochondral ossification at the metaphyseal growth plate of its proximal base, persisting until late adolescence, typically between 15 and 18 years of age.[20] This process contributes to the bone's overall lengthening, with the secondary ossification center at the proximal base appearing radiographically around 2-3 years postpartum.During childhood, the average growth rate of the first metacarpal is approximately 1-2 mm per year, accelerating during pubertal spurts to increments of 5-9 mm over several years, though rates vary by individual and population.[22] Sex differences emerge prominently, with females generally achieving full length by around 14 years and males by 16 years, reflecting earlier skeletal maturation in females.[23] Epiphyseal fusion marks the cessation of growth; the proximal base fuses at a mean age of 15-16 years in females and 16-17 years in males.[23] There is no secondary ossification center at the distal head, with growth primarily occurring at the proximal end.Hormonal influences, particularly growth hormone which promotes chondrocyte proliferation in the growth plate and estrogen which accelerates maturation and eventual fusion, play critical roles in regulating this postnatal development.[24][25] Nutritional factors, including adequate protein, calcium, and vitamin D intake, are essential for supporting optimal bone elongation and density accrual, with deficiencies potentially delaying growth plate activity and overall maturation.[26]
Articulations
Carpometacarpal joint
The carpometacarpal joint of the thumb, also known as the first carpometacarpal (CMC) joint, is a synovial saddle joint formed by the articulation between the base of the first metacarpal bone and the distal surface of the trapezium carpal bone.[27] This joint's distinctive saddle (sellar) morphology, characterized by reciprocal concavity-convexity—the metacarpal base being concave in the dorsopalmar direction and convex in the radioulnar direction, while the trapezium is oppositely shaped—permits multiplanar movement essential for thumb function.[27] The base morphology of the first metacarpal contributes to this saddle shape, facilitating the joint's unique adaptability.[28]The joint is stabilized by a complex of ligaments, including the anterior oblique ligament (also called the beak ligament), which originates from the volar tubercle of the trapezium and inserts onto the volar aspect of the metacarpal base, providing volar restraint.[27] The dorsal radial ligament, part of the dorsal deltoid complex, courses beneath the abductor pollicis longus tendon and acts as a primary stabilizer against dorsal subluxation.[28] Additional support comes from the intermetacarpal ligament, an extracapsular structure connecting the bases of the first and second metacarpals to prevent excessive lateral deviation.[29] The joint capsule is reinforced particularly by the deep anterior oblique ligament, which enhances overall stability during dynamic loading.[28]This saddle joint configuration allows for a wide range of motion, including flexion and extension, abduction and adduction, with typical arcs reaching 50–60 degrees in each plane; opposition, a composite motion involving these components plus slight pronation-supination, enables up to 50–60 degrees of functional opposition for prehensile activities.[28] The reciprocal concavity-convexity provides a biomechanical advantage by accommodating both rotational and translational movements, promoting circumduction and precise positioning of the thumb relative to the fingers.[29]
Metacarpophalangeal joint
The metacarpophalangeal (MCP) joint of the thumb is a condyloid synovial joint that articulates the rounded, convex head of the first metacarpal with the concave base of the proximal phalanx of the thumb. This configuration enables primary movements of flexion and extension, along with limited abduction and adduction, facilitating precise thumb positioning during grip and pinch activities.[30][31]Lateral stability is provided by the radial and ulnar collateral ligaments, which originate from the epicondyles of the metacarpal head and insert onto the base of the proximal phalanx and the volar plate; these ligaments tighten during extension to prevent excessive lateral deviation. The volar aspect of the joint is reinforced by a thick fibrocartilaginous palmar (volar) plate that blends with the collateral ligaments and forms a proximal volar recess, allowing the proximal phalanx to glide smoothly over the metacarpal head during flexion.[32][33][34]Embedded within the palmar plate are two constant sesamoid bones that articulate with the palmar surface of the metacarpal head, connected by an intersesamoid ligament; these sesamoids enhance the mechanical efficiency of the flexor pollicis brevis and adductor pollicis tendons by acting as a pulley system, redirecting force and protecting the tendons from compression against the bone.[35][36]The typical range of motion at the thumb MCP joint includes 45–60° of flexion and 10–20° of extension, with these limits influenced by the tautness of the collateral ligaments and volar plate.[37][31]
Vascular and neural supply
Blood supply
The blood supply to the first metacarpal bone primarily derives from the princeps pollicis artery, a branch of the radial artery that arises in the distal forearm and courses along the palmar aspect of the bone, providing nutrient branches to its shaft and head.[38][39]Dorsal perfusion is supplied by branches of the radial artery, including the first dorsal metacarpal artery, which originates proximal to the bone's base and extends along its dorsal surface to nourish the shaft and head, often anastomosing with palmar vessels.[40][41]At the base, additional nourishment comes from the first palmar metacarpal artery, which arises from the deep palmar arch (formed by the radial artery's deep branch) and supplies the proximal region via recurrent branches.[42][39]The nutrient artery, typically originating from the princeps pollicis artery, enters the bone through a foramen located in the mid-portion of the shaft, usually on the medial surface, to vascularize the medullary cavity.[43][11]These vessels form extensive anastomoses, creating a periosteal arcade around the bone that ensures redundant perfusion through connections between the dorsal metacarpal arteries, deep palmar arch, and perforating branches.[38][39]Venous drainage parallels the arterial supply, draining into the radial vein and cephalic system.[38]
Innervation
The sensory innervation of the skin overlying the first metacarpal bone is provided by the palmar cutaneous branch of the median nerve on the volar aspect, which supplies the thenar eminence and adjacent palmar skin, while the dorsal aspect receives innervation from the superficial branch of the radial nerve.[44][28] The dermatomal distribution for the thumb region, including the first metacarpal, primarily involves the C6 and C7 spinal segments, with C6 predominantly covering the thumb and radial forearm.[45]Motor innervation to the thenar muscles that attach to the first metacarpal—such as the abductor pollicis brevis, opponens pollicis, and the superficial head of the flexor pollicis brevis—is supplied by the recurrent motor branch of the median nerve, which arises in the distal forearm and courses toward the thenar eminence.[46] The deep head of the flexor pollicis brevis may receive dual innervation from the ulnar nerve in some cases, but the primary motor supply remains median nerve-dominated.[46]Articular innervation to the joints involving the first metacarpal, particularly the carpometacarpal and metacarpophalangeal joints, arises from branches of the median nerve (including the recurrent motor and superficial palmar branches) and the radial nerve (superficial and dorsal articular branches), providing sensory feedback to these structures.[47] These articular branches contribute to proprioception and pain sensation in the thumb base.[28]Anatomical variations in the innervation of the first metacarpal region can occur due to the Martin-Gruber anastomosis, a connection between the median and ulnar nerves in the forearm that transfers motor fibers from the median nerve to the ulnar nerve distally, potentially altering the expected median nerve supply to thenar muscles in up to 44% of individuals.[48] This anastomosis may result in atypical motor distribution, where ulnar nerve injury spares certain thenar functions due to median crossover fibers.[49]
Function
Biomechanics
The first metacarpal bone exhibits high compressive strength, primarily attributable to its triangular shaft cross-section, with the apex oriented volarly and consisting of denser bone that resists significant compressile forces from the flexor aspect.[10] This structural adaptation enhances the bone's load-bearing capacity during hand activities, allowing it to support substantial axial forces transmitted from the thumb ray.During pinch and grip maneuvers, the first metacarpal facilitates torque generation at its base, enabling effective force transmission for precision and power tasks. Stress distribution along the bone is uneven, with a significant portion of the load concentrated on the dorsal cortex during opposition, reflecting the biomechanical demands of thumb positioning and the stabilizing role of dorsal ligaments.The material properties of the first metacarpal include typical cortical bone density contributing to its rigidity and resistance to deformation under load. In kinematic models of hand function, the bone is typically represented as a rigid lever within the thumb ray, facilitating multiplanar motion at the carpometacarpal joint while maintaining structural integrity.[50]
Role in thumb opposition
The first metacarpal bone plays a pivotal role in thumb opposition, a movement essential for grasping and manipulating objects, primarily through its rotational capability at the carpometacarpal (CMC) joint. This joint's saddle-shaped articulation allows the metacarpal to undergo axial rotation, positioning the thumb's palmar surface toward the fingers to achieve pulp-to-pulp contact.[51] The laxity in the joint capsule further facilitates this secondary rotation, enabling the thumb tip to oppose the finger pads effectively during fine motor tasks.[52]This rotational motion synergizes with the thenar muscles, including the opponens pollicis, abductor pollicis brevis, and flexor pollicis brevis, which collectively drive around 50 degrees of metacarpal rotation during full opposition.[51] These muscles originate from the metacarpal's base and insert along its length, providing the torque needed to flex, abduct, and pronate the thumb in coordination with the bone's mobility.[46]The first metacarpal's contribution to opposition underpins precision grip, accounting for roughly 50% of overall hand dexterity by allowing stable opposition against the other digits.[53] This enhanced functionality stems from the thumb ray's ability to generate targeted force and adaptability in daily activities like pinching or holding tools.[54]Evolutionarily, the first metacarpal represents an adaptation in humans, being shortest yet more mobile than the other metacarpals to support a fully opposable thumb, with longer thumbs relative to the fingers compared to other primates.[55] This robust structure, combined with increased thumb length relative to the fingers, evolved to facilitate advanced manipulation, distinguishing human hands from those of other primates.[56][57]Clinically, the first metacarpal's position during opposition is evaluated using the Kapandji opposition score, which grades the thumb's ability to touch specific palmar sites from 0 to 10 based on metacarpal alignment and rotation.[58] This assessment incorporates the bone's rotational excursion to quantify opposition proficiency, aiding in the diagnosis of mobility impairments.[59]
Clinical significance
Fractures
Fractures of the first metacarpal bone, which forms the base of the thumb, are common hand injuries, accounting for approximately 25% of all metacarpal fractures, with over 80% occurring at the base.[60] These fractures typically result from high-energy trauma such as falls onto an outstretched hand, sports injuries, or direct blows, and they require prompt evaluation to assess stability and joint involvement due to the bone's critical role in thumb opposition and grip strength.[61]The most prevalent type is Bennett's fracture, an oblique intra-articular fracture at the base of the first metacarpal, characterized by a two-part break with subluxation of the metacarpal shaft due to the pull of the abductor pollicis longus tendon.[62] This injury occurs from an axial load applied to a partially flexed and abducted thumb, often seen in scenarios like a fall or punch.[63] Another base fracture is Rolando's fracture, a more severe, comminuted intra-articular injury presenting as a Y- or T-shaped pattern with at least three fragments, resulting from a high-energy axial load that crushes the articular surface.[62]Shaft fractures of the first metacarpal are less common and typically manifest as transverse or oblique breaks, often accompanied by soft tissue damage, arising from direct trauma such as a blow to the thumb.[62]Head fractures are rare and usually extra-articular, though they can involve the metacarpophalangeal joint; they stem from hyperextension or axial compression forces on an extended digit, leading to potential instability at the joint.[64]Immediate management prioritizes anatomic reduction to preserve thumb function and prevent complications like arthritis or malunion. Non-displaced or minimally displaced fractures, including stable Bennett's variants with less than 1 mm step-off or 30° angulation, can be treated with closed reduction and immobilization in a thumb spica cast or splint for 3-6 weeks.[61] Unstable, displaced, or intra-articular fractures—such as Rolando's or comminuted shaft types—generally require surgical intervention via open reduction and internal fixation (ORIF) using K-wires, lag screws, or plates to restore alignment and joint congruity.[65]
Degenerative conditions
The first metacarpal bone is commonly affected by degenerative conditions, particularly at its base where it articulates with the trapezium to form the carpometacarpal (CMC) joint of the thumb. ThumbCMCosteoarthritis (OA) represents the most prevalent degenerative pathology involving this bone, characterized by progressive cartilage loss, bone remodeling, and jointinstability due to the saddle-shaped joint's inherent mobility.[66] Radiographic prevalence of thumbCMCOA increases with age, affecting up to 33% of women and 11% of men in their 50s and 60s, with women experiencing higher rates due to hormonal and biomechanical factors.[66]The severity of thumb CMC OA is classified using the Eaton-Littler system, which delineates four stages based on radiographic findings from lateral views of the trapeziometacarpal joint. Stage I involves subtle joint space widening from synovitis or ligamentous laxity, with normal articular contours. Stage II shows mild joint space narrowing and osteophytes less than 2 mm in size, without significant subluxation. Stage III features more pronounced narrowing, osteophytes exceeding 2 mm, and metacarpal subluxation greater than one-third of the joint width. Stage IV extends degeneration to the adjacent scaphotrapezial joint, with severe narrowing and deformity.[67]Symptoms of thumb CMC OA centered on the first metacarpal base include localized pain exacerbated by pinching or grasping activities, thumb weakness, stiffness, and swelling at the joint.[68]Imaging reveals joint space narrowing, osteophyte formation, and subchondral sclerosis—dense bone thickening beneath the cartilage—as key indicators of degeneration, often confirmed via X-rays or MRI.[69]De Quervain's tenosynovitis, a degenerative stenosing condition of the first dorsal extensor compartment, indirectly impacts the first metacarpal by inflaming the abductor pollicis longus and extensor pollicis brevis tendons, which insert at the bone's base, leading to radial wrist pain and restricted thumb motion.[70] In rheumatoid arthritis (RA), an autoimmune inflammatory disorder, the first metacarpal undergoes erosive changes at its base (CMC joint) and head (metacarpophalangeal joint), with marginal bone erosions driven by synovial pannus formation, occurring in up to 70% of hand-involved RA cases and correlating with disease duration.[71]Management of degenerative conditions affecting the first metacarpal prioritizes conservative approaches initially, progressing to surgical intervention for advanced disease. Splinting stabilizes the thumb CMCjoint, reducing pain and improving function in many early-stage cases over 4-6 weeks of use. Corticosteroid injections into the joint or tendon sheath provide short-term relief by decreasing inflammation. For severe stages III-IV unresponsive to nonoperative measures, trapeziectomy—excision of the trapezium to unload the first metacarpal base—combined with ligament reconstruction yields significant pain reduction and restores pinch strength, though it carries risks of metacarpal shortening. Emerging options as of 2025 include advanced joint replacement techniques offering faster recovery.[72][73][74]