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Tendon

A tendon is a tough, flexible band of dense fibrous connective tissue that connects muscle to bone or other structures, such as the eyeball, serving as a mechanical bridge to transmit the force generated by muscle contraction to enable joint movement and skeletal stability.^[1] Unlike ligaments, which connect bone to bone to maintain structural integrity, tendons specifically facilitate motion by linking contractile muscle tissue to the skeletal system.^[1] Tendons exhibit a hierarchical structure optimized for tensile strength and force transmission, consisting of collagen molecules organized into fibrils, fibers, fascicles, and finally the tendon proper, with all components aligned parallel to the tendon's long axis.^[2] Their composition is dominated by collagen, accounting for 60–85% of dry weight—primarily type I collagen (about 95%)—along with smaller amounts of types III, V, XI, XII, and XIV, as well as non-collagenous elements like proteoglycans (e.g., decorin, comprising ~80% of this category), glycoproteins such as lubricin for lubrication, and elastic fibers including elastin and fibrillins.^[2] This extracellular matrix provides the tendon with remarkable mechanical properties, allowing it to withstand high tensile forces while exhibiting varying strain capacities: energy-storing tendons, like the Achilles, can stretch over 10%, whereas positional tendons typically strain 2–3%.^[2] Tendons play a critical role in locomotion and load-bearing across the body, with over 4,000 named tendons in humans varying in size, shape, and location to suit specific biomechanical demands, such as the robust Achilles tendon at the ankle or the slender flexor tendons in the hand.^[3]^[4] They receive blood supply primarily from surrounding tissues and intrinsic vascular networks, which influences healing potential, and are susceptible to injuries like tendinopathy or rupture due to overuse, aging, or trauma, highlighting their importance in musculoskeletal health.^[4]

Overview

Definition and Basic Characteristics

A tendon is a tough, flexible band of dense fibrous connective tissue that connects muscle to bone or other structures, serving as a mechanical bridge to transmit the forces generated by muscle contraction to the skeletal system.^[4] This structure enables efficient movement by converting muscular effort into precise joint actions while minimizing energy loss.^[5] Tendons are primarily composed of collagen, which constitutes 60–85% of their dry weight, predominantly type I collagen that provides structural integrity.^[2] They exhibit high tensile strength, typically ranging from 50 to 100 MPa, allowing them to withstand substantial loads without rupture, alongside low elasticity that ensures force transmission with minimal deformation.^[6] In adults, tendons are poorly vascularized, with nutrition supplied by both diffusion from surrounding fluids (particularly in sheathed tendons via synovial fluid) and limited vascular networks, contributing to their durability but limiting rapid repair.^[7] Unlike ligaments, which connect bone to bone to stabilize joints, tendons specifically link muscles to bones to facilitate motion.^[4] The human body contains approximately 4,000 tendons, a number that varies across species depending on locomotor demands and anatomical complexity.^[3]

Etymology and Historical Context

The term "tendon" derives from the Medieval Latin tendōn-, tendō, borrowed from Old French tendron and ultimately tracing back to the Ancient Greek ténōn (τένων), meaning "sinew" or "tendon," which evokes the structure's stretched, fibrous quality.^[8] This Greek root aligns with the Proto-Indo-European ten-, signifying "to stretch," reflecting the tendon's role in extending muscular force, while the Latin influence through tendere ("to stretch") further emphasized its elastic properties in early anatomical nomenclature.^[9] In ancient contexts, similar concepts appeared in Egyptian medical texts, where sinews and tendons were part of the metu system—encompassing vessels, ducts, muscles, and cords vital to life—often viewed mystically as conduits for vital energies sustaining the body.^[10] Early historical understanding of tendons emerged in Greek medicine, with Hippocrates (c. 460–370 BCE) describing them as "sinews" (neura in Greek), robust cords connecting muscles to bones and essential for movement, though sometimes conflated with nerves due to shared terminology.^[11] Building on this, Galen (129–216 CE), the Roman physician and anatomist, advanced the distinction between tendons and ligaments in works like Anatomical Procedures, portraying tendons as white, pliant, tear-resistant fibers transmitting muscle contractions to bones, while ligaments served primarily to bind joints, marking a shift toward functional differentiation based on dissection of animal models.^[12] These ancient contributions laid foundational observations, transitioning from empirical wound descriptions to systematic anatomical inquiry. The Renaissance revitalized tendon study through detailed illustrations, as seen in Andreas Vesalius's De Humani Corporis Fabrica (1543), which featured precise woodcuts of human tendons integrated with musculature, correcting Galenic errors via direct cadaver dissection and emphasizing their gross structural attachments.^[13] By the 17th century, early microscopy advanced the understanding of connective tissue structures, pioneering histological analysis beyond macroscopic views. In the 19th century, Rudolf Albert von Kölliker further refined tendon histology, describing their cellular and extracellular components—such as nucleated fibroblasts amid dense fibrous matrices—in his Manual of Human Histology (1853–1854), establishing tendons as specialized connective tissues and bridging microscopic detail with physiological function.^[14] This progression from ancient mystical and descriptive accounts evolved into modern biomechanics, where tendons are analyzed as viscoelastic structures optimizing force transmission, informed by quantitative imaging and material science.^[4]

Anatomy and Structure

Gross Anatomy and Location

Tendons are tough, fibrous connective tissues that typically appear as elongated, cord-like structures or broader flat sheets known as aponeuroses, serving to connect muscle to bone or to other muscles.^[4] These structures vary in shape and size depending on their location and function, with many enclosed within synovial sheaths that provide lubrication to facilitate smooth gliding over bony surfaces during movement.^[4] In the human body, tendons are distributed across major regions, including the upper and lower limbs and the trunk. For example, in the upper limb, the biceps brachii tendon originates from the supraglenoid tubercle of the scapula and the coracoid process, extending through the shoulder joint to insert on the radial tuberosity, forming a key component of elbow flexion.^[15] In the lower limb, the Achilles tendon represents one of the largest examples, connecting the gastrocnemius and soleus muscles to the calcaneal tuberosity of the heel bone; it measures approximately 15 cm in length with an average thickness of 4–7 mm.^[16] Similarly, the patellar tendon links the inferior patella to the tibial tuberosity, spanning roughly 5 cm in length and 20-30 mm in width, while the quadriceps tendon unites the four heads of the quadriceps femoris muscle to the superior patella.^[17] In the trunk, tendons of the erector spinae muscles attach along the vertebral column and ribs, providing support for spinal extension and posture.^[18] Notable variations in tendon organization include sesamoid tendons, which incorporate small sesamoid bones embedded within them to reduce friction and alter force direction at joints; prominent examples occur in the hand, such as within the flexor pollicis brevis tendon at the metacarpophalangeal joint of the thumb.^[19] Additionally, some muscles feature tendinous intersections, transverse fibrous bands that segment the muscle belly, as seen in the rectus abdominis where three such intersections divide the muscle into distinct segments along its length.^[20] The rotator cuff tendons in the shoulder exemplify a specialized grouping, comprising the tendons of the supraspinatus, infraspinatus, teres minor, and subscapularis muscles, which converge to form a continuous musculotendinous cuff encircling the humeral head for joint stability.^[21]

Microscopic Composition

Tendons exhibit a hierarchical organization at the microscopic level, consisting of collagen fibers bundled into primary fiber units, which are further grouped into larger fascicles that form the core of the tendon unit. These fascicles are surrounded by delicate connective tissue sheaths: the endotenon, which forms internal septa separating individual fascicles and providing structural support, and the epitenon, an outer sheath that encases the entire bundle of fascicles. This layered architecture allows for efficient force distribution while maintaining flexibility and resilience.^[22]^[23] The collagen fibers within fascicles are arranged in a parallel, unidirectional alignment, optimizing the tendon's ability to withstand high tensile loads during muscle contraction. A characteristic feature of these fibers is the crimp pattern, a wavy configuration with a crimp wavelength typically ranging from about 20 μm in energy-storing tendons to 100–400 μm in positional tendons, which contributes to the tendon's elasticity by allowing limited extension under low loads before straightening for maximum strength. This microstructural alignment ensures that tendons can transmit forces effectively without fracturing under physiological stress.^[24]^[25] Tendons possess sparse vascularity compared to other connective tissues, reflecting their adaptation for mechanical durability over metabolic activity. In flexor tendons, which are often intra-synovial, blood supply is provided through vincula—thin mesothelial folds containing arteries and veins that connect the tendon to surrounding structures. In contrast, extensor tendons and other extra-synovial types rely on the paratenon, a loose fibroelastic layer that facilitates nutrient diffusion and vascular ingress. This limited perfusion supports tendon longevity but can pose challenges during injury healing.^[26]^[27] Nerve innervation in tendons is of low density, primarily serving proprioceptive functions rather than sensory or motor control. Specialized mechanoreceptors, such as Golgi tendon organs, are embedded among the collagen fibers near the musculotendinous junction, detecting tension changes to provide feedback on muscle force and joint position. This sparse neural network helps regulate movement and prevent overload without compromising the tendon's compact structure.^[28]^[29]

Extracellular Matrix

The extracellular matrix (ECM) of tendons is predominantly composed of type I collagen, which constitutes 60-85% of the dry weight and forms the primary structural scaffold responsible for the tissue's tensile strength.^[30] This collagen is organized into fibrils with diameters ranging from 50 to 500 nm, assembled through a quarter-stagger arrangement where individual collagen molecules are offset by approximately 67 nm along their length, enabling the formation of banded structures visible under electron microscopy.^[31] The triple helix structure of these collagen molecules follows a repeating sequence of (\text{[Gly](/page/Glycine)-X-Y})_n, where glycine (Gly) occupies every third position to facilitate tight packing, X is frequently proline (Pro), and Y is often hydroxyproline (Hyp), stabilizing the helix through hydrogen bonding.^[32] Intermolecular cross-links, such as pyridinoline, further enhance the stability of these collagen fibrils by forming covalent bonds between lysine and hydroxylysine residues, contributing to the ECM's resistance to mechanical stress.^[33] Other key matrix elements include proteoglycans, which account for 1-5% of the dry weight and include decorin as the predominant small leucine-rich proteoglycan that regulates fibril assembly and spacing.^[34] Elastin comprises 1-2% of the dry mass, providing limited recoil properties to the otherwise stiff matrix, while water content reaches 60-70% of the total weight, ensuring hydration and facilitating nutrient diffusion within the avascular tissue.^[35] With aging, the tendon ECM undergoes remodeling characterized by increased cross-linking density, particularly of advanced glycation end-products and enzymatic cross-links like pyridinoline, which stiffens the matrix and reduces its elasticity, potentially predisposing older tendons to injury.^[36] These changes alter the hierarchical organization, leading to larger fibril diameters and decreased compliance without significant shifts in overall collagen content.^[37]

Cellular Components

The primary cellular components of tendons are tenocytes, which comprise approximately 90% of the resident cell population and function as highly specialized fibroblasts responsible for synthesizing and maintaining the extracellular matrix. Recent single-cell sequencing studies have revealed heterogeneity among tenocyte subpopulations with distinct gene expression profiles. In younger tendon tissue, tenoblasts predominate as the immature precursors to tenocytes, exhibiting greater proliferative capacity to support tissue growth and repair. These cells are characteristically elongated and aligned longitudinally parallel to the collagen fibers, enabling efficient force transmission and interaction with the surrounding matrix. Tenocytes display a distinctive morphology with elongated nuclei and a thin, stretched cytoplasm that contains abundant rough endoplasmic reticulum and Golgi apparatus, facilitating the production of collagen and other extracellular proteins. Their stellate shape in cross-section allows sparse distribution in rows between collagen bundles. Due to the relative avascularity of tendon mid-substance, tenocytes maintain a low basal metabolic rate, characterized by quiescence and limited proliferation, which contributes to the tissue's slow remodeling and healing processes. In addition to tenocytes, tendons contain minor populations of other cell types, including chondrocytes within fibrocartilaginous regions such as entheses, where they form a graded interface between tendon and bone to distribute mechanical stress. Resident immune cells, notably macrophages, are present in small numbers and contribute to ongoing tissue remodeling by modulating inflammation and matrix turnover. Tendon cellularity is notably low, with cell densities decreasing progressively with age, which further constrains regenerative potential.^[38]

Physiology and Function

Mechanical Properties

Tendons exhibit remarkable mechanical properties that enable them to withstand substantial loads while transmitting forces efficiently. The ultimate tensile strength of human tendons typically ranges from 50 to 150 MPa, allowing them to endure high stresses without rupture under normal physiological conditions.^[39] The modulus of elasticity, which quantifies the tendon's stiffness, generally falls between 1.0 and 2.0 GPa, reflecting their ability to deform elastically under tension.^[39] These properties vary slightly across tendon types and individuals, influenced by factors such as age and loading history, but they collectively ensure tendons function as durable, compliant connectors between muscle and bone. Tendons display viscoelastic behavior, meaning their mechanical response depends on the strain rate and includes time-dependent phenomena like creep and stress relaxation. This is evident in the characteristic stress-strain curve, which consists of three regions: the initial toe region (up to ~2% strain), where collagen fibers uncrimp; the linear region, where the tendon behaves elastically; and the failure region, marked by progressive damage leading to rupture.^[40] Hysteresis in this curve indicates energy dissipation as heat during loading-unloading cycles, with the area between the curves representing lost energy, which increases at higher strain rates due to the viscoelastic nature.^[40] The Young's modulus E is defined as the ratio of stress \sigma (force per unit area) to strain \varepsilon (relative deformation) in the linear region:

E = \frac{\sigma}{\varepsilon}

This parameter typically yields values of 1-2 GPa for human tendons, with failure occurring at strains of 10-15%, beyond which irreversible damage predominates.^[41]^[42] A key aspect of tendon mechanics is their capacity for elastic energy storage and recoil, particularly in tendons like the Achilles, which can return approximately 90% of stored energy during gait cycles to enhance efficiency.^[43] This recoil contributes to overall locomotion by recycling mechanical energy, though the exact efficiency varies with activity intensity and individual tendon properties.

Role in Locomotion and Force Transmission

Tendons serve as critical intermediaries in the musculoskeletal system, transmitting contractile forces generated by muscles to bones, thereby enabling joint motion and overall locomotion. In the classic Hill-type muscle model, the tendon functions as the series elastic component (SEC), positioned in series with the contractile muscle fibers to absorb and relay forces without significant energy loss. This arrangement allows muscle contractions to produce precise and efficient movements, such as during walking or jumping, where the tendon's elasticity decouples muscle shortening from bone movement, optimizing force application across joints.^[44] A key physiological role of tendons lies in enhancing energy efficiency through the stretch-shortening cycle (SSC), particularly in dynamic activities like running. During the eccentric phase of the SSC, tendons such as the Achilles store elastic energy as they stretch under load, which is then released during the subsequent concentric phase to augment muscle power output. This mechanism reduces the metabolic cost of locomotion by minimizing the work required from muscles; for instance, elastic energy recovery from the Achilles tendon during running can decrease overall muscle work by up to 35%, contributing to greater endurance and speed.^[45] Tendons also provide essential passive stability to joints and posture by generating tension that resists excessive motion. In upright standing, the Achilles tendon maintains ankle stiffness through its non-linear elastic properties, preventing unintended dorsiflexion and supporting balance without constant muscular effort. This passive tension helps stabilize the body against gravitational forces, ensuring efficient energy use during prolonged static postures.^[46] Adaptations in tendon length and properties further refine their role in locomotion, particularly in high-power activities. The length-tension relationship of associated muscles is influenced by tendon length, allowing longer tendons—as observed in elite sprinters—to position muscle fibers near their optimal operating lengths on the force-velocity curve, thereby enhancing power output and stride efficiency. These adaptations enable greater elastic energy storage and rapid recoil, supporting explosive movements like sprinting.^[47]^[48]

Sensory and Regulatory Functions

Tendons contribute to sensory functions primarily through specialized mechanoreceptors that provide feedback on muscle tension and position. Golgi tendon organs (GTOs), located at the musculotendinous junction, serve as key proprioceptors by detecting active and passive tension in the tendon. These encapsulated sensory endings are innervated by group Ib afferent fibers, which transmit signals to the spinal cord to modulate muscle activity. When tension exceeds the GTO threshold—typically in the range of low to moderate forces—these organs activate, triggering autogenic inhibition of the agonist muscle via inhibitory interneurons, thereby preventing excessive force and protecting the tendon-muscle unit from overload. This reflex mechanism enhances proprioceptive awareness during movement by integrating tension feedback with motor control.^[49]^[50]^[51] In addition to proprioception, tendons play a role in pain signaling through nociceptive pathways. Free nerve endings, primarily from small-diameter Aδ and C fibers, are distributed within the tendon tissue and serve as polymodal nociceptors, responding to mechanical, thermal, and chemical stimuli. These endings detect damaging levels of tension or inflammation, initiating pain perception that alerts the body to potential injury. During inflammatory responses, such as in tendinopathy, sensory nerves release neuropeptides including substance P and calcitonin gene-related peptide (CGRP), which amplify nociception and promote vasodilation, edema, and further neuropeptide release in a positive feedback loop. Substance P, in particular, correlates with increased pain and neural sprouting in pathological tendons, while CGRP contributes to neurogenic inflammation.^[52]^[53]^[54] Tendons also exhibit regulatory functions through cellular mechanotransduction and metabolic adaptations. Tenocytes, the primary resident cells, sense mechanical loading via integrins and focal adhesions, transducing physical cues into biochemical signals that regulate gene expression. A prominent pathway involves the Hippo effectors YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), which translocate to the nucleus under appropriate strain to upregulate genes for extracellular matrix production, such as collagen type I, thereby maintaining tendon homeostasis and adapting to load. This mechanoregulation ensures long-term tissue integrity without excessive remodeling. Metabolically, tendons have a low basal rate, with oxygen consumption approximately 7.5 times lower than skeletal muscle, reflecting their avascular nature and reliance on glycolysis. Under stress or hypoxia, tenocytes shift to increased lactate production via elevated glycolytic flux, supporting energy needs while tolerating low oxygen environments.^[55]^[56]^[57]

Development and Maintenance

Embryonic and Postnatal Development

Tendons originate during embryonic development from distinct mesodermal compartments. Axial tendons derive from the sclerotome of somites, while limb tendons arise from the lateral plate mesoderm.^[58] Tendon progenitor cells are marked by the expression of the scleraxis (Scx) gene, a basic helix-loop-helix transcription factor that initiates and maintains tendon lineage specification.^[59] The initial stages of tendon formation involve mesenchymal condensation, occurring around weeks 6-7 of human embryonic development, where progenitor cells aggregate near developing muscles and bones.^[60] By week 12, further maturation includes differentiation of tenocytes and alignment of collagen fibers along the longitudinal axis to form the tendon proper, facilitating force transmission.^[61] At the tendon-bone interfaces, known as entheses, transitional tissues begin to develop during the fetal period, with fibrocartilaginous zones forming postnatally to enable graded mechanical transitions.^[62] Genetic regulation plays a pivotal role in tendon patterning and differentiation. Hox genes, particularly Hox11 paralogs, coordinate regional specification and integration of tendon, muscle, and bone tissues during embryogenesis.^[63] Additionally, transforming growth factor-β (TGF-β) signaling induces Scx expression in progenitors and promotes tenocyte differentiation, ensuring proper tendon morphogenesis.^[64] Postnatally, tendons undergo significant growth and maturation, particularly during childhood, with length increasing approximately 2-3 times in proportion to overall body growth from birth to adulthood.^[65] Mechanical properties, including stiffness and strength, continue to develop through adolescence, reaching peak levels by ages 20-30 due to progressive collagen organization and cross-linking.^[66]

Collagen Synthesis and Tissue Remodeling

Collagen synthesis in tendons primarily occurs within tenocytes, the resident fibroblast-like cells, where type I procollagen is assembled intracellularly through a series of post-translational modifications. The process begins with the transcription and translation of procollagen chains, followed by hydroxylation of proline and lysine residues for stability and glycosylation to facilitate folding and secretion.^[67] Once properly modified, the procollagen trimer is packaged into vesicles and secreted into the extracellular space via exocytosis.^[68] In the extracellular matrix, procollagen undergoes proteolytic cleavage to mature collagen: the N-terminal propeptide is removed by ADAMTS-2, -3, or -14 enzymes, while the C-terminal propeptide is cleaved by bone morphogenetic protein 1 (BMP1). This cleavage enables the spontaneous self-assembly of collagen molecules into quarter-staggered fibrils, which are further stabilized by cross-linking enzymes such as lysyl oxidase. These fibrils aggregate into larger fibers, forming the hierarchical structure essential for tendon tensile strength.^[69]^[68] Tendon tissue remodeling maintains matrix integrity through a balance of synthesis and degradation, with collagen exhibiting a half-life of approximately 300-1000 days in adult humans, reflecting relatively slow turnover compared to other connective tissues. Degradation is mediated by matrix metalloproteinases (MMPs), particularly MMP-1, -2, and -13, which cleave collagen fibrils, while tissue inhibitors of metalloproteinases (TIMPs), such as TIMP-1 and -2, regulate MMP activity to prevent excessive breakdown. This dynamic equilibrium allows tendons to adapt to mechanical demands without compromising structural integrity.^[70]^[71] Mechanical loading, such as from exercise, upregulates collagen synthesis in tenocytes via mechanotransduction pathways, including the PI3K/Akt signaling cascade, which activates transcription factors and enhances procollagen production. Studies in humans show that acute resistance exercise can increase tendon collagen synthesis rates by 50-100% within hours to days post-loading, promoting fibril thickening and improved tensile properties.^[72]^[73] With aging, tendon collagen turnover decreases due to reduced tenocyte proliferative capacity and increased advanced glycation end-product (AGE) cross-links, leading to greater matrix rigidity and brittleness. Collagen solubility, a measure of fibril extractability, declines with age, correlating with diminished remodeling efficiency and heightened injury susceptibility.^[36]^[74]

Factors Influencing Tendon Health

Several lifestyle, environmental, and physiological factors influence tendon health by modulating collagen synthesis, tissue remodeling, and mechanical integrity. Moderate mechanical loading through exercise promotes tendon adaptations, including hypertrophy and increased stiffness, which can enhance tendon strength by approximately 5-10% over training periods of several weeks to months.^[75] In contrast, excessive or overuse loading contributes to the accumulation of microdamage within tendon fibers, impairing self-repair mechanisms and leading to degeneration if not adequately managed.^[76] Nutritional factors play a critical role in maintaining tendon extracellular matrix stability, with vitamin C serving as an essential cofactor for prolyl hydroxylase in the hydroxylation of proline residues during collagen synthesis.^[77] Deficiency in vitamin C, as seen in scurvy, disrupts this process, resulting in weakened collagen structures and tendon fragility due to impaired cross-linking and increased susceptibility to rupture.^[78] Supplementation with collagen peptides has shown mixed efficacy in supporting tendon health, with some studies reporting improvements in tendon cross-sectional area and biomechanical properties when combined with resistance training, while others indicate inconsistent benefits for preventing degeneration.^[79] Hormonal influences significantly affect tendon resilience, particularly in sex-specific ways. Estrogen exerts protective effects on female tendons by enhancing collagen synthesis and maintaining biomechanical properties, potentially reducing degeneration risk during reproductive years.^[80] Conversely, systemic or local administration of corticosteroids accelerates tendon degeneration by suppressing cell proliferation, inducing apoptosis in tenocytes, and inhibiting extracellular matrix production, thereby weakening tendon structure over time.^[81] Age and genetic predispositions further shape tendon health trajectories. Tendons typically achieve peak structural integrity and functional capacity between 20 and 40 years of age, after which age-related declines in cellular activity and collagen turnover lead to reduced stiffness and increased vulnerability to overload.^[66] Genetic variations, such as mutations in the COL1A1 gene, underlie conditions like certain forms of Ehlers-Danlos syndrome, where defective type I collagen production results in tendon hyperextensibility, fragility, and heightened injury risk.^[82]

Clinical Significance

Common Injuries and Pathologies

Tendon injuries can be broadly classified into acute and chronic categories, each presenting distinct pathological features. Acute injuries typically result from sudden, high-force events and include tendon strains and ruptures. Tendon strains are graded from 1 to 3 based on severity: grade 1 involves minor stretching or microtears with minimal fiber disruption and no significant loss of function; grade 2 represents partial tears affecting a portion of the tendon fibers, leading to moderate functional impairment; and grade 3 denotes complete tears or ruptures where the tendon is fully severed, resulting in substantial loss of strength and mobility.^[83] Ruptures are particularly common in weight-bearing tendons like the Achilles, often occurring in athletes or active individuals aged 40 to 60 years during explosive activities such as sprinting or jumping.^[84] Chronic conditions encompass degenerative and inflammatory disorders that develop over time due to repetitive stress. Tendinopathy, a prevalent overuse injury, involves tendon degeneration without prominent inflammation and affects sites like the rotator cuff, where it is common among athletes in overhead sports such as tennis or baseball, with shoulder injury rates up to 30% in collegiate overhead athletes including rotator cuff tendinopathy.^[85] Another common chronic pathology is tenosynovitis, characterized by inflammation of the tendon sheath, often seen in the wrist or hand tendons and leading to restricted gliding motion.^[86] The etiology of these injuries includes mechanical overload, degenerative changes, and systemic factors. Overload, particularly from eccentric loading where the tendon lengthens under tension, is a primary trigger for both acute strains and chronic tendinopathy, as it exceeds the tendon's adaptive capacity.^[56] Degeneration in hypovascular zones—regions with poor blood supply, such as the mid-portion of the Achilles tendon—predisposes to weakening and failure over time.^[87] Systemic conditions like rheumatoid arthritis contribute by promoting widespread inflammation that affects tendon integrity.^[88] Symptoms of tendon injuries generally include localized pain that worsens with activity, swelling, and muscle weakness due to impaired force transmission. In chronic cases like tendinopathy, patients may experience stiffness and reduced range of motion, while tenosynovitis often presents with crepitus—a grating sensation during movement. Diagnostic signs aid in identification; for instance, the Thompson test for Achilles rupture involves squeezing the calf while observing for absent plantarflexion of the foot, indicating discontinuity.^[89]

Healing Mechanisms

Tendon healing following injury is a complex, overlapping process involving three distinct phases: inflammation, proliferation, and remodeling.^[90] The inflammatory phase, lasting approximately 1 to 7 days, is characterized by the influx of inflammatory cells such as neutrophils and macrophages, which release cytokines like interleukin-1 and tumor necrosis factor-alpha to clear debris and initiate repair signals.^[91] This phase sets the stage for subsequent tissue regeneration but can contribute to excessive inflammation if prolonged. The proliferative phase follows, spanning roughly weeks 1 to 6, during which fibroblasts migrate to the injury site and begin synthesizing extracellular matrix components, predominantly type III collagen, to form a preliminary scar tissue bridge.^[91] Tenocyte proliferation is driven by growth factors such as platelet-derived growth factor (PDGF), which stimulates cell migration and division, while vascular endothelial growth factor (VEGF) promotes angiogenesis to supply nutrients and oxygen to the healing area.^[92]^[93] This results in the formation of a disorganized matrix, often leading to scar tissue that lacks the hierarchical structure of native tendon. The remodeling phase begins around 3 months post-injury and can extend for 6 to 12 months or longer, involving the gradual replacement of type III collagen with aligned type I collagen fibers to restore tensile strength and organization.^[91] During this period, matrix metalloproteinases and other enzymes facilitate tissue maturation, though the healed tendon typically achieves only 80-90% of its original biomechanical properties.^[94] Biomechanically, the repaired tendon exhibits significant initial weakness, emphasizing the need for protected loading to prevent failure.^[94] Full functional recovery, including near-normal strength and stiffness, generally requires 6 to 12 months, as collagen cross-linking and fiber alignment continue progressively.^[26] Complications in tendon healing include scar adhesions, which can limit motion by tethering the tendon to surrounding tissues, and re-rupture, with rates of 1-4% following surgical repair and 5-12% in conservative management, influenced by rehabilitation protocols.^[95]^[96] These issues arise from inadequate matrix organization and excessive mechanical stress during early phases.

Diagnosis and Treatment Approaches

Diagnosis of tendon disorders typically begins with a thorough clinical evaluation, including patient history and physical examination to assess pain, swelling, and functional limitations. Specific clinical tests, such as the empty can test for supraspinatus tendon involvement, involve positioning the arm in 90 degrees of abduction and internal rotation with the thumb down, resisting downward pressure to detect weakness indicative of a tear; this test demonstrates high sensitivity for supraspinatus pathology when combined with imaging.^[97]^[98] Imaging modalities play a crucial role in confirming tendon abnormalities. Ultrasound is particularly valuable for dynamic assessment, allowing real-time visualization of tendon structure, motion, and blood flow during movement, with sensitivity often exceeding that of MRI for detecting certain tears like those in ankle tendons.^[99]^[100] Magnetic resonance imaging (MRI) serves as the gold standard for detailed evaluation of tendon tears, especially partial or full-thickness ones greater than 3 mm in depth, providing high-resolution images of tendon integrity, surrounding tissues, and associated pathologies.^[101]^[102] Conservative treatments form the first-line approach for most tendon disorders, emphasizing non-invasive methods to reduce inflammation and promote recovery. The RICE protocol—rest, ice, compression, and elevation—is widely recommended initially to manage acute symptoms and minimize swelling.^[103] Eccentric exercises, such as the Alfredson protocol for Achilles tendinopathy, involve three sets of 15 repetitions twice daily for 12 weeks, focusing on controlled lengthening of the tendon under load to stimulate collagen remodeling and improve tensile strength.^[104]^[105] Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate pain and inflammation, though evidence suggests they do not alter long-term outcomes and should be limited to short-term use.^[106] Surgical interventions are reserved for cases unresponsive to conservative management or severe structural damage. Debridement involves removing degenerative or calcified tissue to preserve healthy tendon portions, often yielding good outcomes with return to weight-bearing in 2 weeks using supportive devices.^[107] Tendon repair techniques, such as percutaneous methods for Achilles ruptures, utilize small incisions to suture the tendon ends, minimizing tissue disruption and facilitating faster rehabilitation compared to open surgery.^[108] Augmentation with grafts, including autografts or allografts, reinforces repairs in chronic or large defects, enhancing biomechanical stability during the healing phases of inflammation, proliferation, and remodeling.^[109] Emerging therapies aim to accelerate tendon repair through biologic augmentation, though evidence remains mixed and further research is needed. Platelet-rich plasma (PRP) injections, derived from autologous blood, deliver growth factors to the injury site; clinical trials show variable results, with some demonstrating improvements in pain and function while meta-analyses indicate no consistent superiority over placebo.^[110]^[111] Stem cell therapies, particularly mesenchymal stem cells, promote tissue regeneration by modulating inflammation and enhancing collagen production; as of 2024, a phase IIa trial has demonstrated safety and proof-of-concept efficacy in treating non-insertional Achilles tendinopathy, with ongoing studies evaluating long-term outcomes.^[112]^[113]

Comparative and Evolutionary Aspects

Tendons in Non-Human Animals

Tendons in non-human animals exhibit diverse structural and functional adaptations tailored to species-specific locomotor demands, differing notably from those in humans by emphasizing energy storage, recoil efficiency, or robustness in extreme environments. In mammals, these adaptations are particularly evident in specialized locomotion. For instance, kangaroos possess highly elastic hindlimb tendons analogous to the Achilles tendon, which stretch during hopping to store and return elastic strain energy, enhancing jumping efficiency and reducing metabolic costs by up to 70% at speeds of 6 m/s.^[114] Similarly, in horses, the superficial digital flexor tendon (SDFT) functions as a key energy-storing structure during galloping, where it stretches and recoils to absorb and release mechanical energy, supporting high-speed propulsion while bearing substantial strain up to 16% per stride.^[115] These mammalian tendons often feature optimized collagen-elastin compositions to balance stiffness and elasticity for repetitive, high-impact activities. In birds and reptiles, tendon adaptations prioritize rapid force transmission over extensive energy storage, reflecting aerial or terrestrial constraints. Bird flight muscles, such as the pectoralis, are typically parallel-fibered with short tendons that minimize compliance, enabling direct power delivery for flapping wings without significant elastic recoil delay.^[116] In contrast, the supracoracoideus muscle has a longer tendon for upstroke control, but overall, avian tendons are reduced in length relative to body size to optimize speed and reduce mass. Reptilian tendons show similar trends, but crocodiles display robust tendons integrated with their jaw adductor musculature, supporting powerful bite forces exceeding 16,000 Newtons through reinforced tendinous insertions that enhance mechanical stability during prey capture.^[117]^[118] Elastin content varies markedly across species, influencing tendon compliance for environmental adaptations. Cetaceans, such as whales and dolphins, have tendons with notably high elastin levels to facilitate elastic recoil during prolonged diving and tail-powered swimming, allowing energy storage for efficient propulsion in aquatic media.^[119] In amphibians, tendons contain elastic fibers that support recoil, suited to short bursts of jumping or crawling.^[120] These variations underscore how tendon composition evolves to match ecological niches, such as buoyancy challenges in cetaceans or terrestrial hopping in amphibians. Veterinary medicine highlights the clinical impact of these adaptations, particularly in performance animals. In racehorses, SDFT tendinitis is a prevalent injury, with incidence rates ranging from 6% to 20% across age groups, often triggered by repetitive galloping strains that exceed the tendon's energy-storage limits and lead to microdamage accumulation.^[121] Such conditions underscore the trade-off between enhanced locomotor performance and injury vulnerability in domesticated species.

Evolutionary Origins and Adaptations

Tendons trace their evolutionary origins to early chordates during the Cambrian period, approximately 500 million years ago, when the phylum first emerged. In the basal chordate Branchiostoma (commonly known as amphioxus), the earliest tendinous structures appear as myosepta—thin, sheet-like connective tissues composed of a two-dimensional array of collagen fibers arranged to transmit tension across multiple directions between muscle segments.^[122] These myosepta represent a primitive adaptation for force transmission in an aquatic environment, predating the more specialized linear tendons seen in jawless vertebrates like hagfish.^[122] Homologs of scleraxis, a key transcription factor involved in tendon progenitor cell specification in vertebrates, have been identified in amphioxus, suggesting conserved genetic mechanisms for connective tissue development across chordates.^[123] Over phylogenetic time, tendons exhibited increased structural complexity, particularly with the transition to tetrapods and terrestrial locomotion around 360 million years ago. In early tetrapods, tendons co-evolved with skeletal muscle and bone to support weight-bearing and propulsion on land, evolving from simple myoseptal sheets into hierarchical bundles capable of handling unidirectional tensile loads. This co-evolution is evident in the development of specialized tendon insertions at muscle-bone interfaces, enhancing force transmission efficiency and enabling more dynamic movement compared to the axial undulations of aquatic chordates.^[122] In jawed vertebrates, further adaptations included fibrocartilaginous pads and sesamoid bones within tendons to manage compressive forces, first appearing in cartilaginous fishes and becoming widespread in bony fishes and tetrapods.^[122] Tendons display diverse adaptations shaped by locomotor demands and ecological pressures. In cursorial mammals, such as antelopes and horses, evolutionary selection has favored longer distal tendons, particularly the Achilles tendon, which store and release elastic energy to improve running efficiency and reduce metabolic cost during high-speed locomotion.^[124] Sexual dimorphism in tendon properties also occurs, with males often exhibiting greater tensile strength and cross-sectional area to support larger body sizes and agonistic behaviors; for instance, male gorillas possess robust tendons adapted for powerful upper limb exertion in territorial displays.^[125] These variations highlight tendons' role in optimizing force transmission for species-specific lifestyles. Fossil evidence provides direct insights into ancient tendon function, including impressions preserved in dinosaur tracks that reveal patterns of force transmission through soft tissues. Such impressions, recording the contours of skin, flesh, and tendons alongside bony structures, indicate that non-avian dinosaurs utilized tendons for efficient load distribution during locomotion, similar to modern vertebrates.^[126] Ossified tendons, common in ornithischian and theropod dinosaurs, further demonstrate evolutionary continuity in tendon mineralization as an adaptation for stiffening the tail and vertebral column to enhance stability.^[122]

Cultural and Practical Uses

Culinary and Nutritional Roles

Tendons, primarily composed of collagen, are utilized in various culinary traditions where their tough, fibrous texture requires slow cooking methods to break down into tender, gelatinous forms. In Vietnamese cuisine, beef tendons are a staple in pho, a noodle soup, where they are simmered for hours in aromatic broth to contribute a chewy texture and rich umami flavor.^[127] Similarly, in Chinese dim sum, beef tendons appear in braised preparations such as suan bao niu jin, marinated with garlic and slow-cooked until soft and succulent.^[128] These preparations often involve blanching to remove impurities before prolonged braising or pressure cooking, enhancing the extraction of collagen into the broth for a silky consistency. In Mexican cuisine, beef tendons may be incorporated into birria, a spicy stew where connective tissues from chuck or shank cuts gelatinize during extended simmering with chiles and spices.^[129] The high collagen content in tendons makes them an excellent source for gelatin production, achieved through hydrolysis where raw tendons are treated with acid or alkali and heated to yield a gel-forming protein. Gelatin derived from tendons typically exhibits a high bloom strength of 200-300 grams, indicating strong gelling properties suitable for culinary applications like stocks and desserts.^[130] This process not only tenderizes the tissue but also enriches soups and stews with natural thickening agents. Nutritionally, tendons are a dense source of protein, with 100 grams of cooked beef tendon providing approximately 146 calories and 35 grams of protein, predominantly from collagen. This protein is rich in essential amino acids such as glycine (comprising about one-third of collagen's structure) and proline, which support connective tissue health but are not complete proteins due to low levels of tryptophan and other essentials.^[131]^[132] Their tough texture necessitates tenderizing techniques like slow cooking, making them less ideal for quick meals but valuable for low-fat, high-protein diets. Culturally, tendon consumption holds significance in various traditions, often linked to beliefs in food-as-medicine principles. In Chinese cuisine and traditional medicine, tendons are prized for their purported benefits to joint and tendon health, aligning with the concept that consuming similar tissues strengthens corresponding body parts, as seen in dim sum offerings and restorative soups.^[133] Mexican birria, featuring tenderized beef including tendons, is a festive dish associated with celebrations, where the collagen-rich broth is thought to nourish and soothe in folk remedies for vitality. In broader folk medicine, tendon-based dishes are traditionally recommended for joint support, reflecting cross-cultural practices of using animal connective tissues to address musculoskeletal concerns. Modern processing of tendons focuses on extracting collagen peptides for supplements, often derived from bovine or porcine sources through enzymatic hydrolysis. A 2024 randomized controlled trial showed that daily doses of 10 grams of collagen peptides alleviated symptoms of knee osteoarthritis, improving pain and joint function without significant adverse effects.^[134] These supplements capitalize on the amino acid profile of tendons, providing bioavailable building blocks for cartilage maintenance. As of 2025, studies on collagen peptides continue to explore their role in joint health, with ongoing meta-analyses supporting efficacy in symptom relief.^[135]

Biomedical and Industrial Applications

In biomedical applications, tendons serve as valuable sources for allografts and xenografts in surgical repairs, particularly for ligament reconstruction. Porcine tendon xenografts, such as decellularized digital extensor tendons, have been employed in anterior cruciate ligament (ACL) reconstruction, demonstrating positive safety and performance outcomes over five years in clinical studies involving 40 patients, with no graft failures reported.^[136] Similarly, porcine bone-patellar tendon-bone xenografts have shown long-term efficacy in human ACL reconstruction trials, providing an alternative to human-sourced grafts by reducing donor site morbidity.^[137] Tissue engineering leverages decellularized tendon matrices as scaffolds to promote regeneration, preserving the extracellular matrix's biomechanical properties while minimizing immunogenicity. These scaffolds facilitate cell adhesion, proliferation, and differentiation, supporting tendon repair in models of rupture and degeneration.^[138] For instance, decellularized tendon-derived scaffolds have been integrated with mesenchymal stem cells to enhance healing at tendon-bone interfaces, as reviewed in studies on their application for osteotendinous junction regeneration.^[139] In research, the rat Achilles tendon injury model is widely used to investigate tendon pathology and therapeutic interventions due to its anatomical similarity to human tendons and reproducibility. This model, involving partial or complete transection, allows quantitative assessment of healing through biomechanical and histological analyses across multiple injury severities.^[140] Additionally, 3D bioprinting techniques utilizing collagen hydrogels enable the fabrication of tendon scaffolds mimicking the aligned fibrillar structure to support tenocyte viability and matrix deposition.^[141] Industrially, collagen extracted from tendons contributes to leather tanning processes by providing raw material for stabilization and enhancement of hides, often derived from trimming wastes to improve product durability.^[142] As of 2025, recycled collagen from tannery waste has been increasingly used as a filling agent to enhance low-quality leather, promoting sustainability.^[143] In pharmaceuticals, tendon-derived collagen is incorporated into delivery systems for hormones like insulin-like growth factor-1 (IGF-1), which stimulates collagen synthesis and improves tendon repair outcomes in preclinical models.^[72] Bioinspired materials drawing from tendon's tensile properties—such as high strength and elasticity—inform robotic actuators, where fiber-reinforced composites replicate muscle-tendon units for enhanced compliance and load-bearing in soft robotics.^[144] Recent advances include CRISPR-based gene editing targeting the scleraxis (Scx) gene to boost tenogenic differentiation and regeneration. In 2024 studies, CRISPR-Cas13 editing of macrophages modulated inflammatory responses in tendon injuries, promoting scarless healing in animal models. Overexpression of Scx via CRISPR in stem cells has further enhanced tendon lineage commitment, offering potential for scalable regenerative therapies.^[145]

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Tendinopathy - Diagnosis and treatment - Mayo Clinic
Mar 22, 2025 · Ultrasound. This type of imaging test uses sound waves to make images of structures within your body, such as muscles and tendons. Magnetic ...
[96]
Use of ultrasonography versus magnetic resonance imaging for ...
Ultrasound results were more sensitive and accurate than MRI in the detection of ankle tendon tears in our study.Missing: clinical tests
[97]
Imaging of Tendons - PMC - NIH
A normal tendon on MRI demonstrates low signal intensity and on sonography, an echogenic fibrillar pattern. MRI is considered the imaging gold standard, ...
[98]
3.0-T MRI of the Supraspinatus Tendon | AJR
MRI of the shoulder has been found to be highly sensitive and specific for detection of full-thickness supraspinatus tendon tears at 1.5-T or lower field ...
[99]
Physical Therapy for Achilles Tendonitis: Expert Treatment
Aug 8, 2025 · The RICE method means rest, ice, compression, and elevation; it is typically used in the initial phase to reduce swelling and discomfort. Pain ...
[100]
Alfredson Protocol for Achilles Tendonitis Explained - Verywell Health
Apr 29, 2025 · The treatment involves doing three sets of 15 eccentric heel drop exercises per day, twice daily, seven days a week, for twelve weeks. You ...Missing: conservative NSAIDs
[101]
Eccentric Exercise for Achilles Tendinopathy: A Narrative Review ...
Jun 5, 2019 · Alfredson's protocol consisted of a 12-week program where the subjects performed solely eccentric strengthening exercises three sets of 15 ...Missing: RICE NSAIDs
[102]
Achilles Tendon Injuries - MedCentral
May 17, 2016 · ⁷Conventional treatment usually consists of RICE (rest, ice, compression, and elevation) and nonsteroidal anti-inflammatory medication (NSAIDS) ...Missing: protocol | Show results with:protocol
[103]
Achilles tendon debridement-overview - OrthOracle
A debridement can be expected to work in 90% of patients with a return to limited weight-bearing possible in most after 2 weeks if using a post-operative boot.<|separator|>
[104]
Surgery for Achilles Injury | NYU Langone Health
Our surgeons perform Achilles repair using a minimally invasive percutaneous technique, in which they make several tiny incisions in the skin along the back of ...
[105]
What does Achilles tendon repair surgery involve?
Dec 23, 2024 · Tendon graft: The surgeon uses a tissue graft to reconstruct some of the tendon. · Tendon transfer: The surgeon moves a healthy foot tendon into ...
[106]
The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing
This systematic review and meta-analysis has found evidence that suggests PRP may provide both short-term and long-term pain relief for tendon and ligament ...
[107]
Do Plasma Injections Improve Chronic Achilles Tendinopathy? - AAFP
Nov 15, 2010 · Results: At 24 weeks, the PRP group had improved their VISA-A score by 21.7 points, and the placebo group improved their score by 20.5 points, ...
[108]
Mesenchymal stem cells: An efficient cell therapy for tendon repair ...
Jun 30, 2023 · MSCs promote tendon repair through four mechanisms: Decreasing inflammation and promoting neovascularization and cell proliferation and differentiation.Mesenchymal Stem Cells: An... · Mscs Decrease The... · Mscs Stimulate Proliferation...
[109]
Autologous stem cells safe for Achilles tendinopathy treatment
May 19, 2024 · This phase IIa study demonstrated the safety of autologous MSC injection for non-insertional Achilles tendinopathy and provides proof-of-concept ...
[110]
Scaling of elastic strain energy in kangaroos and the benefits of ...
Nov 2, 1995 · The potential for elastic energy storage in hoppers is shown to scale with strong positive allometry. This is a function of the structural ...Missing: percentage | Show results with:percentage
[111]
Microdamage in the equine superficial digital flexor tendon - PubMed
The forelimb superficial digital flexor tendon (SDFT) is an energy-storing tendon that is highly susceptible to injury during activities such as galloping ...
[112]
Building a Bird: Musculoskeletal Modeling and Simulation of Wing ...
Whereas most flight muscles are parallel-fibered with short tendons, the supracoracoideus muscle is pennate with a long tendon that likely stores a ...<|separator|>
[113]
New frontiers in imaging, anatomy, and mechanics of crocodylian ...
Jun 20, 2022 · Crocodylian heads are relatively robust ... The jaw muscles of the crocodiles and some relating structures of the crocodilian skull.
[114]
Comparative mechanical and elastic properties of the doral and ...
... elastin in functionally distinct tendons across species. Tendons with an energy-storing function had slightly more elastin content than tendons with a ...
[115]
The elastic system of a pressure-bearing tendon of thebullfrog Rana ...
The compression region exhibited pre-elastic and mature elastic fibers, which were shown to be associated with the surface of the convoluted collagen bundles.
[116]
Risk factors for superficial digital flexor tendinopathy in ... - NIH
Dec 18, 2019 · The SDF tendinopathy prevalence in racehorses is 6% in 2-year-olds, 20% in 3-year-olds, 17% in 4-year-olds and 12% in 5-year-olds and older ...
[117]
The evolution of tendon — morphology and material properties
We conclude that the evolutionary history of tendon gives us insight into the use of model systems for investigating tendon biology.
[118]
Development of somites and their derivatives in amphioxus, and ...
May 14, 2015 · FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression.
[119]
Evidence for an elongated Achilles tendon in Australopithecus
Mar 5, 2020 · In mammals, a long AT serves as a cursorial adaptation that increases the efficiency of rapid locomotion by stretching and releasing stored ...
[120]
Sex differences in tendon structure and function - PMC
It is possible that sex-based differences in tendon morphology, composition and mechanical properties may contribute to the greater susceptibility that women ...
[121]
Who Was That Dinosaur? | AMNH
Prints record skin, flesh and tendon as well as bone. But fossil dinosaurs are only bone, so prints often don't resemble what we have of the printmaker.
[122]
Truly Authentic Vietnamese Pho Recipe - i am a food blog
Rating 4.8 (43) · 1 hrMar 12, 2025 · Tendon is chewy, a little crunchy, and so satisfying in a bowl of otherwise very soft things. It can be extremely hard to find unless you go to ...
[123]
Beef Tendons - Chefs Resources
Tendon is also fairly common at Dim Sum restaurants, marinated with lots of garlic, cooked until soft, and parading around with the name Suan Bao Niu Jin.Missing: pho | Show results with:pho
[124]
Birria de Res Recipe (Beef Birria) - Mexican Please
Rating 4.7 (63) · 6 hr 30 minMay 24, 2024 · Ingredients · 3 lbs. beef brisket or chuck roast · 4-5 Roma tomatoes · 1 onion · 6 garlic cloves · 3-4 Ancho dried chiles · 2-3 New Mexican dried ...
[125]
Extraction and functional characterization of halal gelatin from ...
Oct 14, 2025 · The high bloom gels have a gel strength of 200–300 g, medium bloom gels have 100–200 g and low bloom gelatin gels have a gel strength of 50–100 ...<|control11|><|separator|>
[126]
Calories in Beef Tendon and Nutrition Facts - MyNetDiary
A 100g serving of beef tendon has 146 calories, 0g carbs, 35g protein, 0.6g fat, 79mg cholesterol, 53mg sodium, 7.7mg iron, and 149mg potassium.
[127]
Collagen Supplementation for Joint Health: The Link between ...
Mar 8, 2023 · Although most of the studies report improvements in pain and function, the daily dose is highly variable. Bernardo et al. [101] in a randomized ...3.1. Native Collagen · 4. Clinical Evidence · Table 2
[128]
Joint Health direct link to Liver Health
In TCM, "the Joint/Tendon belongs to Liver Zang". Most of the people believe the pain and stiffness in the back, the neck and the joint are caused by incorrect ...<|separator|>
[129]
Results from a randomized, double-blind, placebo-controlled study
In summary, a daily dietary supplement containing 10 g of collagen peptides (MW 1–3 kDa) demonstrated efficacy in alleviating osteoarticular pain and improving ...
[130]
Five‐year clinical study of a novel porcine xenograft for anterior ...
Sep 23, 2025 · Porcine digital extensor tendon (p‐DET) xenograft was used for anterior cruciate ligament (ACL) reconstruction in 40 patients with follow‐up to ...
[131]
Xenograft bone-patellar tendon-bone ACL reconstruction - NIH
Sep 6, 2023 · This report describes the long-term outcomes from the first human clinical trial using a porcine xenograft ACL reconstruction device.
[132]
Decellularized and Engineered Tendons as Biological Substitutes
Among biological scaffolds, the use of decellularized tendon-derived matrix increasingly represents an interesting approach to treat tendon ruptures. We ...
[133]
Advances focusing on the application of decellularization methods ...
Our review assesses the application of various decellularized scaffolds in tendon-bone healing and its potential mechanisms.
[134]
Quantitative Comparison of Three Rat Models of Achilles Tendon ...
Mar 27, 2019 · Utilizing three distinct models of rat Achilles tendon injury, the objective of this study was to define and compare the effects and ...
[135]
Exploring the Frontier of 3D Bioprinting for Tendon Regeneration
Aug 7, 2024 · This review elucidates how 3D bioprinting holds promise for tendon repair and regeneration, detailing the steps involved and the various approaches employed.
[136]
Extraction of collagen from raw trimming wastes of tannery
Feb 1, 2016 · A simple and effective method to extract collagen from trimming waste is established using acetic and propionic acid.
[137]
Bioinspired actuators with intrinsic muscle-like mechanical properties
Sep 24, 2021 · This study presents a bioinspired soft actuator, named HimiSK (highly imitating skeletal muscle), designed by spatially arranging a set of synergistically ...
[138]
[PDF] Crispr strategies for stem cell engineering: a new frontier in ...
This review will abridge the past and present of CRISPR for the regeneration of bone, cartilage, skeletal muscle, tendon, and ligament, highlighting the current ...