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Focal hyperhidrosis

Focal hyperhidrosis, also known as primary hyperhidrosis, is a medical condition characterized by excessive sweating in localized areas of the body, such as the palms, soles, underarms, and face, that occurs independently of heat, exercise, or emotional stress.^[1] This form of hyperhidrosis is idiopathic, meaning it arises without an identifiable underlying medical cause, and primarily affects otherwise healthy individuals through overactivity of the eccrine sweat glands due to faulty nerve signals.^[2] Unlike secondary hyperhidrosis, which results from systemic conditions like diabetes or thyroid disorders and often involves generalized sweating, focal hyperhidrosis is confined to specific regions and is bilateral, typically ceasing during sleep.^[1] The condition affects approximately 2.8% to 3% of the general population, with no significant gender predominance, though it is more prevalent among individuals of Japanese descent.^[2]^[3] Onset usually occurs during childhood or adolescence, with an average age of 25 years, and symptoms often peak in the second or third decade of life and typically persist, though some older reports suggest potential improvement in later years.^[4]^[5] Common sites include the axillae (underarms, affecting 51% of cases), feet (29%), palms (25%), and face or scalp (20%), where sweating can be visible as beads of perspiration or lead to wet clothing and skin maceration.^[4] A familial pattern is observed in 30% to 50% of cases, suggesting a genetic predisposition that may involve hyperactivity of the sympathetic nervous system.^[4] Symptoms manifest as profuse, uncontrollable sweating that interferes with daily activities, such as gripping objects, writing, or social interactions like handshaking, and may be exacerbated by triggers including anxiety, high humidity, caffeine, or physical exertion.^[6] Additional complications can include skin softening and peeling, chafing, secondary infections, or body odor due to bacterial overgrowth in moist areas.^[6] The excessive sweating stems from overstimulation of cholinergic receptors on eccrine glands, leading to increased acetylcholine release and impaired thermoregulatory feedback in the hypothalamus.^[2] This autonomic dysfunction results in sweating that exceeds the body's needs for temperature control, significantly impacting quality of life for those affected.^[2]

Overview and Classification

Definition and Characteristics

Focal hyperhidrosis, also known as primary hyperhidrosis, is defined as idiopathic excessive sweating confined to specific focal areas of the body, occurring at levels that exceed the physiological requirements for thermoregulation and without an identifiable underlying cause.^[4]^[7] This condition manifests in otherwise healthy individuals, with sweating episodes happening at least once per week and typically not during sleep.^[7]^[8] Key characteristics include a symmetric distribution affecting both sides of the body equally and an onset that usually begins in childhood or adolescence, often before the age of 25 years.^[7]^[8] Unlike generalized hyperhidrosis, which involves widespread sweating over the entire body, focal hyperhidrosis is limited to discrete regions and is not associated with systemic disorders.^[4] It is also distinct from secondary hyperhidrosis, where excessive sweating results from an underlying medical condition, medication, or external factor, often presenting more diffusely and potentially during sleep.^[7]^[8]

Types and Affected Areas

Focal hyperhidrosis is classified into subtypes based on the primary affected body regions, with the most common forms involving the palms, soles, axillae, face or scalp, and areas around the mouth triggered by eating.^[9] Palmar hyperhidrosis affects the hands, leading to excessive sweating on the palms; plantar hyperhidrosis impacts the feet, particularly the soles; axillary hyperhidrosis occurs in the underarm areas; craniofacial hyperhidrosis involves the face and scalp; and gustatory hyperhidrosis manifests as sweating around the mouth or face during gustatory stimulation, such as eating spicy foods.^[10]^[11] Prevalence varies by subtype and age group, with axillary hyperhidrosis being the most common overall, affecting approximately 50-68% of cases in adults, while palmar and plantar forms predominate in adolescents, often with onset before age 18.^[9]^[11] Craniofacial hyperhidrosis accounts for about 20% of cases, and gustatory hyperhidrosis is less frequent at around 2%.^[9]^[11] These subtypes primarily involve the eccrine sweat glands, which are densely concentrated in apocrine-poor areas such as the palms and soles, where they produce a watery, odorless sweat in response to sympathetic nervous system signals, independent of thermoregulation.^[9]^[10] Rare variants include isolated hyperhidrosis of the trunk or thighs, which may present as localized or segmental sweating without involvement of the typical sites.^[10]^[9]

Etiology and Pathophysiology

Genetic Factors

Focal hyperhidrosis exhibits strong familial aggregation, with studies reporting that up to 65% of affected individuals have a positive family history, indicating a significant hereditary component.^[12] This pattern suggests an autosomal dominant mode of inheritance with variable penetrance, as evidenced by multi-generational transmission observed in multiple pedigrees, without sex linkage.^[12] The variable penetrance accounts for skipped generations and incomplete expression within families, supporting the genetic basis while highlighting the role of modifying factors.^[13] Genome-wide linkage analyses have identified specific chromosomal loci associated with focal hyperhidrosis, particularly primary palmar hyperhidrosis. One key locus maps to chromosome 14q11.2-q13, spanning approximately 6 cM between markers D14S1070 and D14S990, based on linkage studies in affected families showing maximum LOD scores exceeding 3.0.^[14] This region is implicated in sweat gland regulation, though no specific causative gene has been definitively identified within it. Additional loci, such as on chromosome 2q31.1, have been reported in other family cohorts, underscoring genetic heterogeneity.^[15] Genetic associations extend to variants in genes involved in the cholinergic signaling pathway, which regulates eccrine sweat gland activity. For instance, polymorphisms in the butyrylcholinesterase (BCHE) gene, including the -116A variant (rs1126680) and K-variant (rs1803274), have been observed exclusively in patients with primary hyperhidrosis, suggesting a contributory role in cholinergic metabolism.^[16] Similarly, the nicotinic acetylcholine receptor alpha 1 subunit (CHRNA1) has been linked to enhanced sweat gland responsiveness in affected individuals.^[17] Candidate genes such as inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) and forkhead box A1 (FOXA1) have also been implicated in sweat gland regulation.^[12] Overall, focal hyperhidrosis is considered a polygenic disorder, arising from the interaction of multiple genetic variants rather than a single mutation, which explains the variability in clinical presentation and the incomplete linkage to any one locus across all cases.^[18] This multifactorial genetic architecture likely interacts with environmental influences to trigger overactive eccrine glands in predisposed individuals.

Pathophysiological Mechanisms

Focal hyperhidrosis arises from the overstimulation of eccrine sweat glands by the sympathetic nervous system, which is cholinergic in this context, leading to excessive acetylcholine release at neuroglandular junctions independent of thermoregulatory demands.^[19] This neurogenic overactivity results in profuse perspiration in localized areas, driven by heightened sympathetic impulses that exceed normal physiological responses to emotional or thermal stimuli.^[20] The eccrine glands themselves remain structurally normal, with no increase in gland number or histopathological changes, indicating that the disorder stems from functional hyperactivity rather than glandular abnormalities.^[19]^[4] Central nervous system involvement plays a key role, with dysregulation potentially originating in the hypothalamus, which serves as the primary sweat center integrating emotional and thermoregulatory signals. Hyperactivity or reduced inhibition in hypothalamic pathways may lead to abnormal cortical control of emotional sweating, distinct from thermoregulation, as evidenced by the absence of sweating during sleep in affected individuals.^[21] Projections from the hypothalamus descend to the spinal cord's intermediolateral cell column at levels T2-T3, where sympathetic preganglionic neurons exhibit increased activity, amplifying signals to postganglionic fibers.^[19] Peripheral components, including a larger number of ganglion cells and elevated acetylcholine expression in thoracic sympathetic chain ganglia, further contribute to this overexcitation.^[21] Aquaporin-5 (AQP5), a water channel protein in the apical membrane of sweat gland ductal cells, facilitates rapid water transport essential for sweat secretion and shows dysregulation in focal hyperhidrosis. Studies reveal upregulated AQP5 mRNA and protein expression in sweat glands of patients with palmar, axillary, and craniofacial subtypes compared to controls, correlating with enhanced acetylcholine-induced calcium signaling that boosts sweat production.^[22] This overexpression increases membrane water permeability without altering gland morphology, supporting AQP5's role in the functional excess of sweat output.^[23]

Clinical Presentation

Symptoms and Signs

Focal hyperhidrosis manifests primarily as visible, profuse sweating confined to specific areas of the body, such as the palms, soles, axillae, or craniofacial region, where eccrine sweat glands are densely concentrated.^[2] This sweating is typically bilateral and symmetric, often appearing as beads of moisture or soaking through clothing and is not provoked by underlying medical conditions.^[24] It is frequently triggered by emotional stress, anxiety, heat, humidity, or physical activity, though it can occur spontaneously without an identifiable stimulus.^[8] Notably, sweating does not occur during sleep, distinguishing it from secondary forms.^[6] The excessive moisture leads to associated signs, including skin maceration, where the affected areas become soft, wrinkled, pale, or fissured due to prolonged wetness.^[24] This environment promotes bacterial overgrowth, resulting in an unpleasant odor from the breakdown of sweat components.^[6] Secondary complications may include skin infections, such as dermatitis or fungal issues, characterized by redness, swelling, peeling, or pain in the sweaty regions.^[8] Symptoms are often episodic or continuous, occurring at least once a week, with symptoms persisting for at least six months, and they tend to worsen with anxiety or emotional triggers.^[2] On physical examination, the condition is evident through direct observation of damp skin in focal areas, and a confirmatory starch-iodine test—applying iodine solution followed by starch powder—produces a blue-black discoloration precisely where sweating occurs, aiding in localization.^[24]

Impact on Quality of Life

Focal hyperhidrosis significantly impairs patients' quality of life, with up to 48% reporting poor or very poor overall well-being due to the condition's disruptive effects on daily activities.^[25] This impairment is comparable to that experienced in chronic conditions such as severe psoriasis or advanced rheumatoid arthritis, as measured by validated quality-of-life instruments.^[26] Patients often describe a profound sense of limitation, where excessive sweating in focal areas like the palms, axillae, or face hinders routine interactions and personal choices, leading to a mean quality-of-life score of 52.4 on a 20-100 scale (higher indicating worse impact).^[26] Socially, focal hyperhidrosis fosters stigma and isolation, with 75% of patients experiencing impaired social lives, including avoidance of handshakes, public speaking, and social events due to visible sweating and fear of judgment.^[25] Approximately 64% report fearing negative reactions from others, such as glares or misunderstandings, which exacerbate embarrassment (reported by 33.3%) and shame (25%).^[27]^[26] These experiences contribute to reduced self-confidence and a reluctance to engage in communal activities, further compounding emotional distress. Occupationally, the condition interferes with professional functioning, affecting 63% of patients through challenges in tasks requiring manual dexterity, such as typing or surgical procedures, or in roles involving customer interaction.^[27] Palmar hyperhidrosis, in particular, is associated with a mean productivity loss of 7.24%, prompting 33% of individuals to select careers that accommodate their symptoms, like avoiding client-facing positions.^[25]^[27] Such limitations not only hinder career advancement but also influence clothing choices and daily work habits to mitigate visible sweating. Psychologically, focal hyperhidrosis elevates rates of anxiety (ranging from 0-49%) and depression (0-60%), with 11.6% of those with localized forms experiencing depression and a higher prevalence (39.2%) in moderate-to-severe cases.^[25]^[28] This often manifests as a "vicious circle" of nervousness triggering further sweating, leading to diminished self-esteem and chronic stress, particularly among females.^[27] Studies utilizing the Hyperhidrosis Disease Severity Scale (HDSS) show that 70% of patients score 3 or 4, indicating severe disease, which strongly correlates with Dermatology Life Quality Index (DLQI) scores of 11-20, reflecting a very large effect on quality of life.^[25] For instance, median DLQI scores reach 13.5 in axillary cases, underscoring the condition's substantial psychological burden.^[25]

Diagnosis

Diagnostic Criteria

The diagnosis of focal hyperhidrosis, also known as primary hyperhidrosis, relies on established clinical guidelines from the International Hyperhidrosis Society (IHS), which emphasize focal, symmetric sweating without identifiable secondary causes.^[29] Key criteria include bilateral and focal excessive sweating that has persisted for at least 6 months, occurring in at least two episodes per week, with onset typically in childhood or adolescence (though craniofacial involvement may begin later).^[29] The sweating must cease during sleep, show no continuous pattern, and not be attributable to underlying medical conditions, medications, or physiological triggers alone; additionally, it should impair daily activities to warrant diagnosis.^[29] Severity is assessed using the Hyperhidrosis Disease Severity Scale (HDSS), a validated four-point qualitative tool that evaluates the impact of sweating on daily life.03534-5/fulltext) Patients rate their condition by answering: "How would you rate the severity of your hyperhidrosis?" with options ranging from grade 1 (never noticeable and never interferes with daily activities) to grade 4 (intolerable and always interferes with daily activities).^[30] Scores of 3 or 4 indicate severe hyperhidrosis requiring intervention, while a one- or two-point improvement post-treatment correlates with approximately 50% or 80% sweat reduction, respectively.^[30] A thorough medical history is essential for confirming the diagnosis and guiding management.^[2] This includes documenting the age of onset, family history (reported in up to two-thirds of cases), emotional or environmental triggers, and patterns of sweating to exclude secondary hyperhidrosis.^[29] Objective confirmation involves gravimetric testing, which quantifies sweat production by weighing the increase in weight of an absorbent material (e.g., cotton gauze) applied to or wiped across the affected area before and after a standardized period, such as 1 minute, under controlled conditions.^[31] Results are often normalized by body surface area to assess severity. This method is reproducible and useful for baseline assessment and monitoring treatment efficacy.^[31]

Differential Diagnosis and Tests

Focal hyperhidrosis must be differentiated from secondary hyperhidrosis caused by underlying medical conditions, which can mimic its focal presentation but often involves generalized sweating or additional systemic symptoms. Key differentials include endocrine disorders such as hyperthyroidism, diabetes mellitus, menopause, and pheochromocytoma; neurological conditions like neuropathy, Parkinson's disease, or stroke; infectious or neoplastic causes including tuberculosis or lymphoma; and medication-induced sweating from antidepressants like SSRIs or antipsychotics.^[2]^[32] Anxiety disorders can also present with excessive sweating as part of heightened autonomic arousal, particularly in social situations, warranting consideration in the differential.^[33] Dermatological conditions like palmoplantar pustulosis may mimic palmoplantar focal hyperhidrosis due to associated sweat leakage and inflammatory changes on the palms and soles.^[34] To exclude secondary causes, initial laboratory tests are essential, including thyroid function tests (e.g., TSH levels) to rule out hyperthyroidism, fasting blood glucose or hemoglobin A1c for diabetes, and pregnancy tests in women of childbearing age to identify hormonal influences.^[2]^[32] A complete blood count, basic metabolic panel, sedimentation rate, and antinuclear antibody testing help detect infections, malignancies, renal dysfunction, or connective tissue disorders.^[2] Additionally, a neurological examination assesses for autonomic dysfunction, such as asymmetric reflexes or sensory deficits suggestive of neuropathy or central lesions.^[2] Advanced confirmatory tests focus on sweat gland function and pattern to distinguish primary focal hyperhidrosis from mimics. The thermoregulatory sweat test involves applying indicator solution to the skin and exposing the body to thermal stress, revealing anhidrotic or hyperhidrotic patterns that indicate eccrine gland abnormalities or autonomic neuropathy.^[2] The quantitative sudomotor axon reflex test (QSART) measures sweat output in response to iontophoresis of pilocarpine, quantifying nerve-mediated sweat production to evaluate postganglionic sudomotor function and exclude small-fiber neuropathy.^[2] These tests are particularly useful when clinical history suggests possible neurological involvement. Red flags prompting investigation for secondary causes include asymmetric or unilateral sweating, onset after age 25, night sweats, or accompanying systemic symptoms like weight loss, fever, or fatigue, which deviate from the typical bilateral, symmetric, and diurnal pattern of primary focal hyperhidrosis.^[2]

Treatment and Management

Topical and Conservative Therapies

Topical antiperspirants represent the first-line treatment for focal hyperhidrosis, particularly for mild to moderate cases affecting the axillae, palms, or soles. Aluminum chloride hexahydrate, typically in 20% concentrations such as Drysol, works by precipitating metal ions with mucopolysaccharides in the sweat ducts, forming a temporary plug that blocks perspiration without halting sweat gland production.^[35] Patients are advised to apply the solution to completely dry skin at bedtime, allowing it to remain for 6-8 hours before washing off in the morning, starting with nightly use until improvement occurs and then tapering to maintenance applications once or twice weekly.^[36] Clinical studies indicate that this approach can achieve up to 82% patient satisfaction for axillary sweating and reduce transepidermal water loss by 30% after four weeks for palmar involvement, though skin irritation may occur and requires application avoidance after shaving.^[35]^[4] Topical anticholinergic agents offer an additional first-line option, especially for axillary hyperhidrosis. Sofpironium bromide gel 12.45% (Sofdra), approved by the U.S. Food and Drug Administration in June 2024 for primary axillary hyperhidrosis in adults and pediatric patients aged 9 years and older, is applied once daily at bedtime to each axilla using a provided applicator and allowed to dry for at least 5 minutes. Phase 3 clinical trials (CARDIGAN-1 and CARDIGAN-2) involving over 700 patients showed that 49% to 64% of treated patients achieved at least a 2-point improvement on the Hyperhidrosis Disease Severity Measure for Axillae (HDSM-Ax-7) scale at week 6, compared to 29% to 48% with vehicle control; more than 60% experienced at least 50% reduction in gravimetric sweat production. Common adverse effects include dry mouth (14%), blurred vision (9%), mydriasis (7%), and application-site reactions such as pain (8%) and erythema (7%).^[37]^[38] Lifestyle modifications complement topical therapies by addressing environmental and behavioral triggers that exacerbate focal hyperhidrosis symptoms. Recommendations include wearing breathable fabrics like cotton or moisture-wicking materials to facilitate evaporation and reduce moisture buildup, along with using absorbent powders or insoles in shoes to manage plantar sweating.^[39] Individuals are encouraged to avoid known triggers such as spicy foods, caffeine, alcohol, and emotional stressors, which can stimulate eccrine glands; maintaining a sweat journal helps identify personal precipitants for targeted avoidance.^[39] These non-pharmacological strategies improve daily comfort and can enhance quality of life, particularly when combined with severity assessments from diagnostic evaluations.^[36] Iontophoresis offers a device-based conservative option primarily for palmar and plantar focal hyperhidrosis, utilizing a mild electrical current passed through tap water or anticholinergic solutions like glycopyrrolate to temporarily disrupt sweat gland function, possibly by inducing hyperkeratosis in the ducts.^[40] Sessions typically last 20-30 minutes, conducted 2-3 times per week initially with hands or feet immersed in shallow trays connected to the device, followed by maintenance once weekly.^[36] Efficacy data from clinical observations show reductions in sweating by 81-91% in responsive patients, with minimal side effects like transient dryness or tingling, though long-term adherence is necessary for sustained benefits.^[40]^[4] Home remedies such as sage tea or baking soda applications have been explored for symptom relief in focal hyperhidrosis but lack robust scientific validation and are not recommended as primary interventions. Sage, consumed as tea or applied topically, may contain tannins that constrict sweat glands, yet evidence is anecdotal with unknown efficacy and potential for interactions.^[41] Baking soda can absorb moisture when used as a powder but risks skin irritation or post-inflammatory hyperpigmentation, particularly in darker skin tones, without proven long-term reduction in sweating.^[41] Consultation with a healthcare provider is essential before incorporating these, as they do not substitute for evidence-based conservative therapies.^[41]

Interventional and Pharmacological Options

For patients with focal hyperhidrosis refractory to topical therapies, botulinum toxin injections represent a key interventional option by temporarily inhibiting acetylcholine release at the neuromuscular junction, thereby reducing sweat gland stimulation. OnabotulinumtoxinA (Botox) is FDA-approved for severe primary axillary hyperhidrosis in adults when antiperspirants are inadequate, with intradermal administration of 50-100 units per axilla distributed across 10-20 sites.^[42] Clinical studies demonstrate significant efficacy, with 80-90% reduction in axillary sweat production lasting 4-12 months, though duration may extend to 9-12 months with repeated treatments.^[43] Common side effects include injection-site pain and transient muscle weakness, but the procedure is generally well-tolerated and reversible.^[44] Oral anticholinergics offer systemic pharmacological control by blocking muscarinic receptors to suppress eccrine gland secretion, suitable for multifocal or widespread focal hyperhidrosis. Glycopyrrolate, at doses of 1-2 mg twice daily (up to 4 mg/day), or oxybutynin, at 5-10 mg/day (titrated to 15-20 mg if needed), achieve 50-70% sweat reduction in responsive patients, particularly for palmar or plantar involvement.^[45] Efficacy varies by individual tolerance, with studies showing improvement in hyperhidrosis severity scores within 2-4 weeks of initiation.^[46] However, anticholinergic side effects such as dry mouth (affecting up to 70% of users), constipation, blurred vision, and urinary retention limit long-term adherence, necessitating dose adjustments or discontinuation in some cases.^[47] Microwave thermolysis using the miraDry system provides a minimally invasive procedure for permanent axillary sweat reduction by delivering targeted electromagnetic energy to destroy eccrine glands through thermolysis, sparing surrounding tissues via a hydro-cooling mechanism. FDA-cleared for primary axillary hyperhidrosis, it typically requires 1-2 sessions spaced 3-6 months apart, each lasting about 60 minutes under local anesthesia.^[48] Pivotal trials report 80-82% average sweat reduction persisting beyond 12 months, with high patient satisfaction due to its durability compared to injectables.^[49] Adverse effects are mostly transient, including swelling, numbness, and discomfort resolving within 1-2 weeks, though axillary hair loss and altered sensation may occur.^[48] For hyperhidrosis exacerbated by emotional triggers, off-label use of beta-blockers like propranolol (10-40 mg as needed) or clonidine (0.1-0.4 mg/day) can modulate sympathetic outflow to reduce episodic sweating, though evidence remains limited to case series and small studies. Beta-blockers inhibit adrenergic stimulation of sweat glands, showing modest efficacy in stress-induced palmar or craniofacial cases without significant cardiac risks at low doses.^[50] Clonidine, an alpha-2 agonist, similarly attenuates central sympathetic activity, with reports of 50-75% symptom relief in focal subtypes, but monitoring for hypotension and sedation is advised.^[51] These agents are often trialed briefly before escalating to more definitive interventions.

Surgical Interventions

Surgical interventions are reserved for patients with severe, treatment-resistant focal hyperhidrosis, typically those scoring 3 or 4 on the Hyperhidrosis Disease Severity Scale (HDSS) after failure of conservative and pharmacological options.^[52] These procedures aim to provide permanent relief by disrupting sweat gland function or sympathetic innervation, though they carry risks of irreversible side effects such as compensatory hyperhidrosis.^[52] Endoscopic thoracic sympathectomy (ETS) is the most established surgical approach for palmar and axillary hyperhidrosis, involving video-assisted thoracoscopic interruption of the sympathetic chain, usually by clipping or cutting at the T2-T4 levels.^[53] Success rates for achieving dryness or significant reduction in targeted areas range from 85% to 95%, with long-term efficacy reported at 94.5% for palmar and axillary symptoms.^[54] However, compensatory hyperhidrosis occurs in 60% to 80% of cases, often affecting the trunk or lower body, leading to dissatisfaction in up to 20-30% of patients over time.^[55] Other risks include Horner's syndrome (1-2.5%), gustatory sweating (up to 50%), and compensatory anhidrosis, with procedural complications like pneumothorax occurring in less than 5%.^[55]^[53] For axillary hyperhidrosis, local excision or curettage targets eccrine sweat glands directly through minimally invasive techniques such as tumescent liposuction-assisted removal or subcutaneous scraping (Shelley's procedure).^[56] These methods yield good to excellent results in 82-90% of cases, with sustained sweat reduction in over 80% at one-year follow-up and minimal impact on surrounding tissues.^[57] Risks are generally low, including infection, scarring, or hematoma in under 10%, making this suitable for localized disease without systemic effects.^[56] Emerging options like laser ablation, particularly with Nd:YAG lasers, offer focal destruction of sweat glands in the axillae via subdermal energy delivery.^[58] Studies report 65-70% sweat reduction immediately post-treatment, with 83% of patients achieving good to excellent outcomes (>50% improvement) after multiple sessions.^[58] Side effects are mild and transient, such as pain (90%), irritation (25%), or hair loss (100%), with no reports of compensatory hyperhidrosis in small cohorts.^[58] Patient selection emphasizes younger individuals (<25 years), low BMI (<28), early-onset symptoms, and absence of sleep-related sweating to optimize outcomes and minimize complications across all procedures.^[52]

Epidemiology

Prevalence and Incidence

Focal hyperhidrosis, also known as primary hyperhidrosis, affects an estimated 1-5% of the global population, with prevalence rates varying across studies due to differences in diagnostic criteria and reporting methods.^[2] In the United States, the condition is reported in approximately 4.8% of individuals, equating to about 15.3 million people, though this figure may underestimate the true burden as many cases remain undiagnosed.^[59] The prevalence is considered underreported globally owing to associated social stigma, which discourages individuals from seeking medical evaluation or participating in surveys.^[60] Incidence rates for focal hyperhidrosis are lower, ranging from 0.13% in the United Kingdom to 0.28% in the United States, reflecting the typically early-life onset rather than frequent new cases in adulthood.^[61] The condition most commonly begins during adolescence, with average onset ages of 13 years for palmar and axillary forms, though it can emerge as early as childhood or up to 25 years.^[4] Once established, focal hyperhidrosis tends to remain stable throughout adulthood without spontaneous progression or resolution in most cases. Geographic variations in prevalence have been observed, with higher rates reported in warmer climates such as tropical or subtropical regions, where environmental factors may exacerbate sweating and influence reporting.^[62] For instance, studies indicate a prevalence of 4.8% in the United States compared to around 5.5% in Sweden, though broader European estimates sometimes fall lower at 1-2% in certain populations.^[59]^[63] In Asian urban settings like Shanghai, self-reported prevalence reaches 14.5%, potentially linked to both climate and higher awareness.^[64] Prevalence estimates have remained relatively stable across studies, though increased awareness since the early 2000s has likely led to higher diagnosis rates.^[65]^[59]

Demographic Patterns

Focal hyperhidrosis, a form of primary hyperhidrosis characterized by excessive sweating in localized areas such as the palms, soles, axillae, or face, typically manifests early in life. The condition most commonly begins during childhood or adolescence, with mean ages of onset reported between 14 and 20 years across multiple studies.^[66]^[59] Prevalence peaks in younger adults, particularly those under 30 years of age, where rates can reach 8.8% in the 18–39 age group, and declines sharply thereafter, dropping to 4.2% in the 40–64 age group and 2.1% in those under 18 or over 65.^[59]^[64] This age-related pattern holds in diverse populations, including dermatology outpatients in North America and Asia, with odds ratios indicating up to sixfold higher likelihood in individuals younger than 30 compared to those over 60.^[64] Gender distribution in focal hyperhidrosis shows variability across studies, with no consistent predominance. In a cohort of medical students in Brazil, prevalence was similar between males (23.1%) and females (19.4%), suggesting comparable risk.^[67] However, clinic-based studies from the United States and Canada report a slight female majority, with 62.8% of patients being female, potentially reflecting differences in healthcare-seeking behavior or site-specific involvement, such as higher plantar sweating in women.^[66] Males, in contrast, may experience greater facial or scalp involvement in some populations.^[66] Overall, gender ratios hover near parity in community surveys but tilt toward females in treatment-seeking groups.^[67]^[66] Ethnic and racial patterns reveal geographic and population-specific differences, with Caucasians demonstrating higher rates of certain subtypes, particularly axillary hyperhidrosis, at 2.5 to 5 times the prevalence seen in Chinese populations.^[64] Individuals of Japanese descent show particularly high rates of palmoplantar hyperhidrosis, reportedly up to 20 times more frequent than in other ethnic groups.^[10] In the United States, over 87% of affected individuals in clinical samples are Caucasian, alongside smaller proportions of African-American (8.4%) and Asian (1.7%) patients, which may reflect both genetic predispositions and access to care.^[66] Conversely, in Brazil, non-white and mixed-race groups exhibit higher prevalence (24.2%) compared to whites (19.3%), indicating potential environmental or genetic modifiers.^[67] Global variations persist, with overall primary hyperhidrosis rates ranging from 3.2% in Indian populations to 16.3% in German cohorts, underscoring the influence of ethnicity and regional factors.^[68] A notable familial component affects demographics, with 35–65% of cases reporting positive family history, suggesting hereditary influences that may cluster within certain ethnic or age groups.^[66] Obesity has been linked to late-onset forms but not typically to early-onset focal hyperhidrosis.^[64] These patterns highlight the interplay of genetic, environmental, and socioeconomic elements in the distribution of the condition.

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Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion
Hyperhidrosis (HH) is a central nervous dysfunction characterized by abnormally increased sweating due to a central dysregulation of sweat secretion.Types Of Sweat · Mechanisms Of Sweat... · Abnormal Sweat Secretion
[21]
Involvement of aquaporin 5 and Na-K-2Cl cotransporter 1 in the pathogenesis of primary focal hyperhidrosis: evidence from the primary sweat gland cell culture | American Journal of Physiology-Cell Physiology | American Physiological Society
### Summary of Aquaporin-5 (AQP5) Role in Primary Focal Hyperhidrosis (PFH) Pathophysiology
[22]
Overexpression of AQP5 Was Detected in Axillary Sweat Glands of ...
Mar 2, 2016 · In summary, our study supported the hypothesis that, in humans, AQP5 may be involved in sweat secretion, and the overexpression of AQP5 in sweat ...
[23]
Hyperhidrosis - Dermatologic Disorders - Merck Manuals
Focal sweating Emotional causes are common, causing sweating on the palms, soles, axillae, and forehead at times of anxiety, excitement, anger, or fear. It may ...Focal Sweating · Treatment References · Key Points
[24]
The Impact of Hyperhidrosis on Quality of Life - NIH
Jan 9, 2023 · Up to 48% of patients with HH report poor or very poor quality of life (QoL) [6]. Excessive sweating can also result in physiological stressors ...
[25]
Hyperhidrosis: prevalence and impact on quality of life - PMC - NIH
The degree of impairment of quality of life (QoL) in patients with hyperhidrosis is comparable to that seen in patients with chronic diseases, such as severe ...
[26]
The impact of hyperhidrosis on patients' daily life and quality of life
Jun 8, 2017 · This study investigated the impact of hyperhidrosis on the daily life of patients using a mix of qualitative research methods.
[27]
43204 Prevalence of depression and social isolation in young adults ...
Axillary hyperhidrosis was most frequently observed (100/125; 80%). The prevalence of depression was higher in moderate to severe HH (39.2%; 20/51) compared to ...
[28]
Diagnosing Hyperhidrosis | Official Site
Duration - For a primary Hh diagnosis, excessive sweating symptoms or episodes that have been going on for 6+ months with 2+ episodes per week are considered. ...
[29]
[PDF] Hyperhidrosis Disease Severity Scale
The Hyperhidrosis Disease Severity Scale (HDSS) is a disease-specific, quick, and easily-understood diagnostic tool that provides a qualitative measure of ...
[30]
Gravimetry in sweating assessment in primary hyperhidrosis ... - PMC
Gravimetry is easy, reproducible and fast method of evaluation of sweating. The reference values are stable and can serve as a qualifying and follow-up tool.
[31]
Palmar hyperhidrosis: clinical, pathophysiological, diagnostic and ...
Score above 100 is indicative of serious cases and, above 125, very serious. 39. - Campos Questionnaire (Campos): developed specifically to evaluate the ...
[32]
Excessive sweating Causes - Mayo Clinic
Primary hyperhidrosis may be at least partly hereditary. If the excess sweating is due to an underlying medical condition, it's called secondary hyperhidrosis.
[33]
A fluorescence imaging technique suggests that sweat leakage in ...
Jan 3, 2024 · A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis.Missing: hyperhidrosis differential diagnosis
[34]
Aluminum Chloride - International Hyperhidrosis Society | Official Site
Aluminum chloride is the partially neutralized form used in cosmetic antiperspirants, while aluminum chloride hexahydrate is among the most effective ...
[35]
Hyperhidrosis - Diagnosis and treatment - Mayo Clinic
Oct 25, 2024 · Sweat test. Moisture-sensitive powder indicates the presence of heavy sweating (top) compared with hands after surgery to treat hyperhidrosis ( ...
[36]
Hyperhidrosis: 6 tips dermatologists give their patients
Triggers often vary from person to person. Keeping a sweat journal can help you find yours. To keep a sweat journal, write down when your sweating occurs and ...
[37]
Iontophoresis - International Hyperhidrosis Society | Official Site
One study found that iontophoresis helped 91% of patients with excessive palmoplantar (hands and feet) sweating. Another study showed that iontophoresis reduced ...
[38]
Natural Remedies - International Hyperhidrosis Society | Official Site
Natural remedies to treat hyperhidrosis may include herbal substances such as sage tea or sage tablets, chamomile, valerian root, and St. John's Wort.
[39]
[PDF] Botox Label - accessdata.fda.gov
Safety and effectiveness of BOTOX have not been established for the treatment of axillary hyperhidrosis in pediatric patients under age 18. 1.6. Blepharospasm ...
[40]
Treatment of hyperhidrosis with Botox (onabotulinumtoxinA)
Thus, the recommended dose selected was 50 U injected intradermally in 0.1 to 0.2 mL aliquots to each axilla, evenly distributed over 10 to 15 sites ...
[41]
Assessing Botulinum Toxin Effectiveness and Quality of Life in ...
Jan 3, 2024 · Botulinum toxin therapy proved effective in reducing sweat production and improving the quality of life in axillary hyperhidrosis patients over a one-year ...
[42]
Use of Systemic Therapies to Manage Focal Hyperhidrosis - PMC
For oral administration, 5–10 mg daily is usually required for relief of HH, but doses up to 15 or 20 mg daily may be required., Wolosker did a randomized ...Anticholinergic Agents · Glycopyrrolate · Beta Adrenergic Blockers
[43]
Oxybutynin for the Treatment of Primary Hyperhidrosis - NIH
Dry mouth, headache, constipation, and urinary retention are relatively minor side effects seen with oxybutynin, particularly when the daily dose exceeds 15 mg ...
[44]
Hyperhidrosis: A Review of Recent Advances in Treatment ... - NIH
Nov 3, 2022 · Anticholinergic-related side effects included headache, dizziness, syncope, abnormal sensation in the eye, and bronchitis. Notably, urinary ...Missing: dosing | Show results with:dosing
[45]
Clinical Evaluation of a Microwave Device for Treating Axillary ... - NIH
Mar 27, 2012 · The miraDry system is a novel microwave energy device that can be used to treat axillary hyperhidrosis through selective heating of the lower ...
[46]
Patient satisfaction after miraDry® treatment for axillary ... - NIH
Oct 15, 2024 · In their study from 2012, Hong et al. reported an average reduction in sweat production of 82% after two treatments. The most common side ...
[47]
Current and Emerging Medical Therapies for Primary Hyperhidrosis
Oct 27, 2016 · Two case reports have shown that clonidine 0.2–0.4 mg is effective in reducing craniofacial hyperhidrosis [41]. Injectable Therapies. Botulinum ...
[48]
Primary hyperhidrosis: an updated review - PMC - PubMed Central
145 Dosages that have been used include 0.1 or 0.15 mg twice daily with side-effects including dry mouth, dizziness, constipation and sedation.146 The ...
[49]
Interventions for hyperhidrosis - PMC - PubMed Central - NIH
Surgical interventions are also permanent solutions. Several methods (excision, curettage) work by removing eccrine sweat glands (Nawrocki 2019). Endoscopic ...
[50]
Effectiveness, success rates, and complications of different ... - NIH
Our study results suggest that excision, cauterization, and clipping are effective and reliable in the treatment of primary focal hyperhidrosis.
[51]
Endoscopic thoracic sympathectomy for primary hyperhidrosis - NIH
Dec 20, 2024 · Bilateral endoscopic thoracic sympathectomy (BETS) demonstrated a long-term efficacy rate of 94.5% in treating palmar and axillary primary ...
[52]
Endoscopic thoracic sympathectomy for primary hyperhidrosis of the ...
A majority of the patients (98.1%) were relieved, and 95.5% were satisfied initially. Permanent side effects included compensatory sweating in 67.4%, gustatory ...Missing: focal | Show results with:focal
[53]
Surgical treatment of axillary hyperhidrosis by suction-curettage of ...
Conclusion: Suction-curettage of sweat glands is a minimally invasive surgical technique that is easy to perform, safe, has high rates of success and relatively ...
[54]
The Effectiveness of Local Surgical Technique in Treatment of ...
Jan 29, 2019 · Of the total of 62 axillae (31 cases), 56 (90.3%) showed good to excellent results; hair growth decreased in 58 (93.6%). The mean HDSS score ...Missing: success | Show results with:success
[55]
The Efficacy of Long-Pulsed, 1064-nm Nd:YAG Laser ... - PMC - NIH
The long-pulsed, 1064-nm Nd:YAG laser with hair reduction setting can stand as a potential therapeutic option for axillary HH since it is as effective as ALCL ...
[56]
Hyperhidrosis: an update on prevalence and severity in the United ...
Oct 15, 2016 · Current results estimate the prevalence of hyperhidrosis at 4.8 %, which represents approximately 15.3 million people in the United States.
[57]
Treatment Patterns, Depression, and Anxiety Among US Patients ...
Sep 11, 2020 · The prevalence of hyperhidrosis in the USA is estimated to be 4.8%; however, patients may be underdiagnosed, undertreated, and may not seek ...
[58]
Hyperhidrosis: A targeted literature review of the disease burden
Jul 31, 2023 · The incidence of hyperhidrosis ranged from 0.13% in the UK to 0.28% in the USA, with a higher rate in females. The prevalence of hyperhidrosis ...
[59]
Hyperhidrosis Epidemiology Forecast 2025-2034 - Market Research
May 13, 2025 · Warmer climates, particularly those in tropical or subtropical regions, have higher rates of excessive sweating, as individuals living in hot ...
[60]
Prevalence and Characteristics of Hyperhidrosis in Sweden
Sep 1, 2016 · The prevalence of primary hyperhidrosis was 5.5%, and severe primary hyperhidrosis (HDSS 3-4 points) occurred in 1.4%. Secondary hyperhidrosis was observed in ...
[61]
Hyperhidrosis Prevalence and Demographical Characteristics in ...
Apr 22, 2016 · The prevalence of primary hyperhidrosis is very similar in Shanghai and in Vancouver, at 14.5% and 12.3% respectively.Missing: country | Show results with:country
[62]
Global research trends and hotspots of hyperhidrosis: a bibliometric ...
Apr 22, 2025 · ETS is the standard surgical treatment for hyperhidrosis of the palms, face, and axillae, with a success rate of over 95% (44). The ...
[63]
None
### Summary of Epidemiological Study Findings on Primary Focal Hyperhidrosis Demographics
[64]
Primary hyperhidrosis prevalence and characteristics among ... - NIH
Sep 13, 2019 · PH prevalence among Rio de Janeiro medical students was 20.56%, similar between men and women, predominating associated presentations, axillary, palmar and ...
[65]
Hyperhidrosis and its Prevalence in a Population - Crimson Publishers
Sep 26, 2018 · The prevalence of primary hyperhidrosis has been the subject of examination by several groups focusing on populations that differ in ethnic ...