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Ganoderma tsugae

Ganoderma tsugae Murrill, commonly known as hemlock varnish shelf or hemlock reishi, is a species of wood-decay fungus in the genus Ganoderma, belonging to the family Ganodermataceae within the order Polyporales.^[1]^[2] First described by American mycologist William Alphonso Murrill in 1902 from specimens on hemlock in New York, it is classified under the kingdom Fungi, phylum Basidiomycota, subphylum Agaricomycotina, and class Agaricomycetes.^[2] The fungus produces distinctive laccate (varnished) fruiting bodies that are typically reddish-orange to orange with a shiny, lacquered surface, a pseudostipitate or stipitate stipe, and a shelf-like cap that can reach up to 20 cm in diameter.^[3]^[4] Its context (internal tissue) is nearly pure white and homogeneous, while the pore surface is pale and whitish, darkening with age or handling; the double-walled basidiospores are pigmented.^[3]^[4] These features distinguish it from related species like G. lucidum, which prefers broadleaf trees, and G. sessile, which lacks a true stipe.^[4]^[5] Native to North America, G. tsugae is primarily a saprophyte that decomposes the wood of conifers, especially Tsuga canadensis (eastern hemlock), though it also occurs on other conifers like Douglas-fir in the western regions.^[2]^[4] It is distributed east of the Rocky Mountains, from Canada through the eastern and midwestern United States to northern Arizona and New Mexico, often fruiting year-round in warmer southeastern areas.^[4]^[3] Ecologically, it plays a key role in forest nutrient cycling by breaking down lignin-rich wood, and its presence indicates active decay in tree trunks and roots.^[3]^[5] In addition to its ecological importance, G. tsugae has been utilized in traditional Chinese medicine, particularly in cultivated forms from Taiwan and Asia, for its bioactive compounds including polysaccharides, triterpenoids, and proteins.^[6]^[5] Scientific research highlights its potential therapeutic effects, such as anti-inflammatory activity by suppressing superoxide anion formation and nitric oxide production, as well as antioxidant and antifibrotic properties.^[5] Notably, ethanol extracts of the fruiting body demonstrate antitumor effects, inducing S-phase arrest and apoptosis in doxorubicin-resistant lung adenocarcinoma cells via modulation of the PI3K/Akt pathway, and enhancing chemotherapy efficacy.^[7] These attributes position G. tsugae as a promising candidate for further pharmacological investigation, akin to its congener G. lucidum.^[7]^[5]

Taxonomy

Classification

Ganoderma tsugae belongs to the kingdom Fungi, division Basidiomycota, class Agaricomycetes, order Polyporales, family Ganodermataceae, genus Ganoderma, and species G. tsugae https://pmc.ncbi.nlm.nih.gov/articles/PMC8541142/. The binomial nomenclature Ganoderma tsugae Murrill was established in 1902 by American mycologist William Alphonso Murrill in the Bulletin of the Torrey Botanical Club https://www.indexfungorum.org/names/namesrecord.asp?RecordID=239416. Within the genus Ganoderma, a group of wood-decaying polypores, G. tsugae occupies a distinct phylogenetic position https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.724451/full. Molecular analyses, including multi-locus sequencing of nuclear ribosomal DNA and mitochondrial genes, place G. tsugae in a clade associated with North American conifer hosts, separate from the Eurasian G. lucidum sensu stricto (now often referred to as G. lingzhi) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199738. Divergence time estimates from genomic comparisons indicate that G. tsugae split from the common ancestor of G. lingzhi and G. sinense approximately 21 million years ago, reflecting adaptations to temperate coniferous environments https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.724451/full. G. tsugae is distinguished as a separate species from G. lucidum primarily through host specificity to conifers like hemlock (Tsuga spp.) and genetic markers such as sequence variations in the internal transcribed spacer (ITS) region and translation elongation factor 1-alpha (tef1) gene, which form discrete clades in phylogenetic trees https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199738. These molecular distinctions resolve earlier taxonomic confusion within the G. lucidum species complex, confirming G. tsugae's status as an independent entity adapted to eastern North American ecosystems https://pmc.ncbi.nlm.nih.gov/articles/PMC6051579/.

Etymology and history

The genus name Ganoderma derives from the Ancient Greek words ganos (brightness or sheen) and derma (skin), alluding to the lustrous, varnished appearance of the fruiting body's cap surface.^[8] The specific epithet tsugae is the genitive form of Tsuga, the botanical genus encompassing hemlock trees, reflecting the fungus's primary association with these coniferous hosts.^[8] Ganoderma tsugae was first formally described in 1902 by American mycologist William Alphonso Murrill as part of his pioneering surveys of North American polypores, which aimed to catalog the continent's diverse fungal flora previously underrepresented in European-focused mycological literature.^[9] Murrill's description, based on specimens from decaying hemlock wood, appeared in the Bulletin of the Torrey Botanical Club and marked one of 17 new Ganoderma species he identified, advancing early 20th-century understanding of the genus in the New World.^[10]^[11] Early post-description literature often conflated G. tsugae with the morphologically similar G. lucidum due to overlapping features like the laccate cap, resulting in G. tsugae being treated as a synonym in works such as those by Atkinson (1908) and Haddow (1931).^[11] This taxonomic ambiguity was resolved through phylogenetic analyses in the 1990s and 2000s; for instance, Moncalvo et al. (1995) used rDNA sequences to delineate G. tsugae as a distinct clade closely related to G. oregonense but separate from European G. lucidum sensu stricto.^[12] Subsequent studies, including Hong and Jung (2004) employing mitochondrial SSU rDNA, reinforced this distinction, confirming G. tsugae's unique North American conifer-host ecology.^[13] Today, G. tsugae is stably recognized in authoritative databases like Index Fungorum, upholding Murrill's original classification.^[10]

Description

Macroscopic features

Ganoderma tsugae produces a shelf-like bracket fruiting body typical of flat polypores in the genus Ganoderma. The basidiocarp is annual, often growing solitarily or in overlapping clusters on host trees, with a woody texture that renders it inedible in its raw form due to toughness. The context is whitish to cream-colored, homogeneous, and spongy to tough, up to 5 cm thick.^[8]^[14] The cap, or pileus, is kidney- or fan-shaped, spanning 5–30 cm in width and 0.5–3 cm in thickness. Its upper surface displays a distinctive shiny, varnish-like sheen, colored reddish-brown to maroon, often with concentric zones and radial furrows; young caps feature a contrasting white to yellow margin that fades with maturity.^[8] The stipe is typically lateral, though sometimes central or absent, measuring 2.5–15 cm in length and 1–4 cm in thickness, with a surface matching the cap's varnished reddish-brown hue and irregular form.^[8]^[14] The hymenial surface on the cap's underside consists of adnate pores, numbering 4–6 per mm, initially white to tan and suede-like, which bruise and darken to brown with age; the spore print is brown.^[8] Fruiting bodies typically emerge from late spring (May–June) through fall, persisting into winter as hardened structures.^[8]^[15]

Microscopic features

Ganoderma tsugae exhibits a trimitic hyphal system, comprising generative, skeletal, and binding hyphae. The generative hyphae are hyaline to pale yellow, thin- to thick-walled, branched, and septate with clamp connections. Skeletal hyphae are thick-walled and non-septate, while binding hyphae are pale yellow, thick-walled, and branched.^[14]^[8] The basidiospores are ellipsoid to ovoid, with a truncate base, measuring 8–12 µm in length and 5–7 µm in width. They are brown to golden-brown, thick-walled, and double-layered, featuring coarse echinulations on the outer wall and interwall pillars, which contribute to their chambered appearance under microscopy. In 5% KOH, the spores appear brown.^[11]^[8] In the hymenial layer, cystidia are absent. Basidia are club-shaped to cylindrical-clavate, measuring 19–45 × 7–8.5 µm, typically 4-spored, with clamps at the base and yellowish-green pigmentation.^[8] Diagnostic traits include the double-walled basidiospores with echinulate ornamentation, which distinguish G. tsugae in mycological keys, often alongside the trimitic hyphal system. The cap cuticle shows positive reactions for melanin-like pigments, contributing to its laccate appearance, as observed in staining with 1% Congo red or KOH mounts.^[11]^[14]

Distribution and ecology

Geographic distribution

Ganoderma tsugae is primarily found in eastern North America, east of the Rocky Mountains, with its range extending from southern Canada, including provinces such as Ontario, Quebec, New Brunswick, and Nova Scotia, southward through the Appalachian Mountains to northern Georgia and Alabama.^[8]^[14]^[16] This fungus inhabits temperate forests, favoring areas with eastern hemlock (Tsuga canadensis) stands, though it is rare west of the Rockies, with isolated reports from the mountains of northern Arizona and New Mexico.^[11] Fruiting typically occurs from May to June in northern regions, with secondary flushes possible in the fall; in the southeastern U.S., fruiting can happen year-round, and the durable fruitbodies persist through all seasons.^[3]^[8] Specimens are documented in major herbaria, including the New York Botanical Garden, and post-2010 surveys via citizen science applications like iNaturalist have expanded occurrence records across its native range.^[17] The species' distribution remains constrained by the availability of suitable coniferous hosts, and it holds no invasive status.^[11]

Habitat and ecological role

Ganoderma tsugae primarily inhabits temperate forests in eastern North America, where it exhibits strong host specificity for conifers, particularly the eastern hemlock (Tsuga canadensis), though it has been recorded on other species such as spruce (Picea spp.) and fir (Abies spp.). It colonizes fallen logs, stumps, and occasionally living or stressed trees, often at the base or butt area, thriving in cool, moist environments typical of hemlock-dominated woodlands.^[14]^[8]^[18] Ecologically, G. tsugae functions as a white-rot decomposer, acting primarily as a saprotroph on dead wood while occasionally behaving as a weak parasite on living hosts, causing butt rot in the heartwood. It breaks down lignin and other complex polymers through the secretion of specialized enzymes like laccases and peroxidases, resulting in a characteristic fibrous white residue and facilitating the decay of woody tissues. This process is essential for breaking down recalcitrant plant material that other decomposers cannot utilize.^[8]^[14]^[19]^[18] The fungus plays a key role in its life cycle by producing annual fruiting bodies on decaying wood from spring through fall, releasing spores that contribute to the dispersal and perpetuation of decomposition processes. Through this activity, G. tsugae aids in nutrient cycling within forest ecosystems by recycling carbon, nitrogen, and other elements locked in lignified wood back into the soil, supporting broader forest health and succession.^[14]^[8] Interactions of G. tsugae with other organisms are largely opportunistic, with no known mutualistic relationships; however, it indirectly benefits from the impacts of the hemlock woolly adelgid (Adelges tsugae), an invasive pest introduced in the mid-1980s, which causes hemlock dieback and increases available dead wood substrate, leading to heightened fruiting in affected areas. Despite this short-term boon, the ongoing decline of eastern hemlock populations due to adelgid infestations and associated stressors threatens the long-term viability of G. tsugae, linking its population trends to host availability since the 1980s.^[20]^[21]^[14]

Cultivation

Growth requirements

Ganoderma tsugae, commonly known as hemlock reishi, requires specific environmental and nutritional conditions for successful propagation in controlled cultivation settings, mimicking its natural decomposition of coniferous wood. Optimal growth involves a combination of suitable substrates, controlled temperature and humidity, and careful inoculation to support mycelial colonization and fruiting body development.^[22] The primary substrates for G. tsugae cultivation include conifer logs, particularly from hemlock (Tsuga spp.), or supplemented hardwood sawdust blocks enriched with wheat bran or other agricultural by-products such as cotton seed husk and corn cob. These lignin-rich materials provide the necessary structural carbohydrates, with an ideal carbon-to-nitrogen ratio of approximately 30:1 to 40:1 promoting robust mycelial growth and fruiting. The substrate pH should be maintained between 5.0 and 5.5, while moisture content is kept at 60-65% to prevent drying or waterlogging during colonization. Although G. tsugae prefers coniferous hosts, it can adapt to some hardwoods indoors, though yields may be lower.^[22]^[23] Temperature requirements vary by growth stage: mycelial colonization occurs best at 25-30°C, while fruiting bodies develop optimally at 20-28°C, with pinning initiated around 18-24°C. High humidity is essential, ranging from 85-95% during primordia formation and fruiting to support antler-like or shelf-shaped development. Light exposure should be minimal during mycelial growth (complete darkness preferred), but brief low-intensity light (500-1,000 lx) aids pinning, followed by moderate levels (3,000-5,000 lx) for maturation. Nutrient supplementation with carbon sources like glucose or sucrose, nitrogen from wheat bran, and inorganic salts such as KH₂PO₄ and CaSO₄ at 100-150 mg/L enhances biomass production in liquid or solid media.^[22]^[23] Spawn methods typically involve grain spawn (e.g., rye or millet) or sawdust spawn inoculated at a 5-10% rate into sterilized substrate bags or jars, with dowel plugs used for log cultivation. Incubation for full colonization on sawdust substrates takes 4-6 weeks under dark, humid conditions, though log methods extend to 9-18 months outdoors. Tissue culture or protoplast techniques can produce monokaryotic strains for improved hybridization.^[23]^[24]^[22] Key challenges in G. tsugae cultivation include heightened contamination risks from competing molds and bacteria due to its slower mycelial growth rate (approximately 2.1 mm/day at 20-25°C) compared to G. lucidum, which can delay colonization and reduce yields. Spore germination is notoriously difficult, often requiring specialized mutagenesis for strain improvement, and maintaining sterile conditions is critical to avoid losses in humid environments.^[25]^[22]

Commercial practices

Commercial cultivation of Ganoderma tsugae primarily employs indoor methods using sterilized short logs or sawdust bags, as well as outdoor techniques involving buried hemlock logs in temperate climates suitable for the species. Short logs, typically 15-24 cm long and 15 cm in diameter from conifers like hemlock or larch, are harvested during dormancy, enclosed in ventilated synthetic bags, and sterilized at 100°C for 10 hours or under pressure at 1.5 kg/cm² for 1.5 hours before inoculation with spawn.^[26] Once colonized, logs are embedded 16-21 cm deep in soil or sawdust beds to promote fruiting, mimicking natural hemlock substrates while enabling controlled environments.^[26] Outdoor cultivation on buried hemlock logs leverages the fungus's preference for coniferous hosts, with logs inoculated directly in forested areas after surface sterilization or non-sterile treatment to accelerate natural colonization. In Taiwan, G. tsugae is commercially cultivated as Songshan lingzhi using conifer-based substrates for traditional medicine.^[27]^[28] Yield optimization focuses on environmental manipulation to produce desirable antler-shaped fruiting bodies, akin to traditional lingzhi forms, which are harvested after 3-6 months of growth. High carbon dioxide levels (>0.1%) during early fruiting encourage elongated antler development, while controlled light exposure—100-200 lux for primordia initiation and 150-200 lux on a 12-hour cycle for fruiting—directs growth toward light sources, allowing cultivators to shape unique forms.^[26] Primordia typically form 50-60 days post-spawning, with harvest occurring 25-35 days later when bodies mature, yielding 150-180 g per fruiting body on larch or hemlock substrates under optimized conditions.^[27] Post-harvest drying at 60°C within 2-3 days preserves morphology and bioactive integrity.^[26] Global production of G. tsugae is concentrated in North America (USA and Canada) and Asia (Taiwan and China), remaining small-scale relative to G. lucidum due to its niche hemlock association and slower growth. Liquid-state fermentation in 20 m³ tanks has enabled limited large-scale mycelial production, though fruiting body cultivation dominates for market-preferred forms.^[22] Quality control emphasizes sterile techniques to prevent contamination, including autoclaving substrates at 100°C for 9 hours and maintaining 90-95% humidity with low CO₂ (<0.1%) during differentiation.^[27] Strain selection via protoplast fusion and DNA fingerprinting ensures purity, while adherence to Good Agricultural Practices (GAP) guidelines supports organic certification, verifying absence of pesticides and synthetic inputs.^[22] Economically, G. tsugae is processed into dietary supplements like extracts and powders, capitalizing on post-2000 demand for immune-supporting medicinals, with the broader reishi market valued at approximately USD 5 billion as of 2025.^[29] Liquid fermentation reduces costs compared to solid-state methods, enhancing scalability for supplement production in Asia and North America.^[22]

Uses

Culinary applications

Ganoderma tsugae is non-toxic and technically edible, though its mature fruiting body is tough, woody, and intensely bitter, rendering it unsuitable as a primary food source.^[30] The young, soft margins—often referred to as the white "lip"—can be harvested early in development for culinary use, where they exhibit a more tender texture and milder flavor.^[31] These tender parts may be diced finely and sautéed like other edible mushrooms or added to soups for subtle earthy notes.^[31] For broader applications, the mushroom is commonly dried and powdered to make teas, or processed into alcohol extracts to infuse flavor in beverages, though its bitterness often requires balancing with sweeteners or other ingredients.^[30] Nutritionally, G. tsugae at its optimal coloration stage offers a low-calorie profile typical of fungi, with high dietary fiber content contributing to its fibrous texture.^[32] It contains notable polysaccharides, around 1.18% on a dry weight basis, alongside moderate crude protein levels (up to 48% dry weight) and minimal fats (less than 3%).^[30]^[32] Essential amino acids and minerals such as potassium and phosphorus are present, but overall macronutrient density is geared toward fiber and carbohydrates rather than proteins or lipids.^[30] In cultural contexts, G. tsugae sees occasional use in North American foraging traditions, particularly in the northeastern United States, where foragers target young specimens on hemlock trees for experimental dishes or teas.^[31] Unlike its relative G. lucidum, which holds a prominent place in Asian culinary-medicinal preparations, G. tsugae lacks deep-rooted traditional food roles in Asian cuisines and is primarily encountered as a wild harvest in North America.^[30] Safety considerations include avoiding raw consumption, as the indigestible chitin in its cell walls can cause digestive irritation such as stomach upset or nausea.^[33] No unique allergies are reported for G. tsugae beyond general sensitivities to mushrooms, though individuals with known fungal allergies should exercise caution.^[33]

Traditional medicinal uses

Ganoderma tsugae, particularly the variety cultivated in Taiwan known as Songshan lingzhi, has been extensively incorporated into Chinese traditional medicine for treating various diseases, drawing parallels to the revered reishi mushroom (Ganoderma lucidum).^[34] Cultivation of G. tsugae in Taiwan began in the late 1960s, leading to its integration into traditional medicine by the 1970s.^[35]^[36] This adoption in Taiwanese and Chinese herbalism emphasizes its role in supporting immune function and addressing skin ailments, with documented use emerging prominently since the mid-20th century alongside increased cultivation efforts.^[28] In broader Chinese traditions, use of G. tsugae draws from the ancient applications of related Ganoderma species to promote overall health and longevity, reflecting its status as a popular tonic in folk practices.^[37] Preparation methods in these traditions typically involve hot water decoctions to extract bioactive polysaccharides for internal consumption, aimed at enhancing vitality and resilience, while fresh caps are applied topically for healing skin issues and wounds.^[38] Ethnobotanical records from the early 20th century highlight its empirical application in certain communities for alleviating insomnia and arthritis, akin to related Ganoderma species.^[37] In North American contexts, indigenous and folk practices have utilized fresh caps as wound dressings and brewed teas for general vitality, though less formally documented than Asian counterparts.^[39] The popularity of G. tsugae surged post-1990s, fueled by global interest in G. lucidum's therapeutic reputation, leading to expanded herbal applications despite comparatively sparse historical records specific to this species.^[37]

Pharmacology

Active compounds

Ganoderma tsugae contains several key bioactive compounds, primarily polysaccharides and triterpenoids, which contribute to its pharmacological profile. These molecules are predominantly found in the fruiting bodies and mycelia, with polysaccharides comprising water-soluble fractions and triterpenoids being alcohol-soluble bitter components.^[40]^[41] Polysaccharides in G. tsugae are mainly β-glucans, including branched structures such as (1→3)-β-D-glucans with (1→6)-β-D-glucosyl side chains, often referred to as ganoderans A, B, and C. These constitute 10-40% of the dry weight in fruiting bodies, with β-1,3-D-glucan being the predominant form. They are typically extracted using hot water (e.g., 100°C for 3 hours) followed by ethanol precipitation to isolate the alcohol-insoluble fraction.^[40]^[41] Triterpenoids, numbering over 100 distinct types across Ganoderma species including G. tsugae, are lanostane-type compounds such as ganoderic acids A-Z (e.g., ganoderic acids A, B, C, D, E, C5, C6, G) and tsugaric acids A-C. In G. tsugae fruiting bodies, total triterpenoid content reaches up to 8% of dry weight, with specific ganoderic acids comprising 0.28-2.20% and optimized fermented samples yielding around 5.4%. These are extracted via alcohol solvents (e.g., 70-80% ethanol at 80°C) or acidic ethyl acetate partitioning, often achieving 4.2% yield from the alcohol-soluble fraction.^[42]^[41] Other notable constituents include sterols like ergosterol, immunomodulatory peptides and proteins, nucleotides such as nucleic acids, and antioxidants mimicking superoxide dismutase activity. These are present in varying amounts, with ergosterol and peptides detected in hot-water extracts alongside polysaccharides.^[40] Concentrations of these compounds vary by factors such as wild versus cultivated strains, with wild G. tsugae exhibiting higher triterpenoid levels (e.g., up to 5.4% versus lower in cultivated), and growth stage, where triterpenoids and polysaccharides increase during fruiting body maturation. Analytical techniques like high-performance liquid chromatography (HPLC) with UV detection at 252 nm are used for quantification, employing gradients of acetonitrile and acetic acid.^[41]

Therapeutic effects

Research on Ganoderma tsugae has demonstrated several potential therapeutic effects, primarily through preclinical studies involving in vitro and animal models, with limited clinical data in humans. These effects are largely attributed to bioactive polysaccharides and triterpenoids, which modulate immune responses and cellular processes. While promising, most evidence comes from rodent and cell line experiments, highlighting the need for further human trials to confirm efficacy and safety. Polysaccharides extracted from G. tsugae mycelium have shown immunomodulatory properties by enhancing splenic natural killer (NK) cell activity and increasing serum interferon production in mice. In a 1992 study, oral administration of G. tsugae mycelium to mice significantly boosted NK cell cytotoxicity against YAC-1 tumor cells and elevated interferon-γ levels, suggesting potential for bolstering innate immunity.^[43] Similar effects were observed in later mouse models where G. tsugae polysaccharides stimulated cytokine production, including interleukin-2 and tumor necrosis factor-α, thereby activating macrophages and T cells. The anticancer potential of G. tsugae triterpenoids has been explored in cell line studies, particularly for inhibiting tumor proliferation and invasion. Additionally, G. tsugae extracts exhibited anti-invasive effects in lung metastatic melanoma cells, reducing migration and matrix metalloproteinase activity in both cell cultures and mouse xenografts.^[44] In wound healing models, G. tsugae-derived materials promote tissue repair through enhanced cellular proliferation and extracellular matrix production. Topical application of sacchachitin, a chitin-based membrane from G. tsugae fruiting bodies, accelerated wound closure in mouse excisional models by stimulating fibroblast proliferation and increasing collagen synthesis, as evidenced by upregulated proliferating cell nuclear antigen and hydroxyproline levels.^[45] Taiwanese studies from the late 1990s confirmed these effects, showing that G. tsugae extracts improved re-epithelialization and reduced inflammation in full-thickness skin wounds via fibroblast migration and type I collagen deposition.^[46] G. tsugae exhibits antioxidant and anti-inflammatory activities that mitigate oxidative stress and related pathologies. In hyperlipidemic mouse models induced by high-fat diets, G. tsugae supplementation reduced malondialdehyde levels and restored superoxide dismutase activity, thereby alleviating hepatic oxidative damage.^[47] Its lipid-lowering effects were demonstrated by decreasing serum total cholesterol and low-density lipoprotein in these models, alongside downregulation of pro-inflammatory cytokines like TNF-α.^[47] Anti-inflammatory mechanisms involve inhibition of NF-κB signaling, as seen in airway inflammation mouse models where G. tsugae reduced bronchoalveolar lavage fluid eosinophils and histamine release, suggesting antihistamine-like properties. Overall, while preclinical data support these applications, clinical evidence is preliminary and warrants rigorous investigation.

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Powdered whole reishi mushroom is possibly safe when used for up to 16 weeks. Reishi mushroom can cause dizziness, dry mouth, itching, nausea, stomach upset, ...Missing: tsugae | Show results with:tsugae
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Ganoderma tsugae supplementation alleviates bronchoalveolar ...
Ganoderma tsugae (a Chinese mushroom Songshan lingzhi) cultivated in Taiwan is extensively used in Chinese traditional medicine to treat different diseases.
[35]
Chinese Herbal Medicine Ganoderma tsugae Displays Potential ...
Sep 8, 2019 · Ganoderma tsugae (GT), a restricted species of Lingzhi specifically cultivated in Taiwan, has been shown to have high antioxidant activity ...
[36]
[PDF] Mycosphere Essays 20: Therapeutic potential of Ganoderma species
Nov 16, 2017 · Ganoderma tsugae is one of the popular traditional medicines used in China due to its various beneficial medicinal properties (Wasser & Weis ...Missing: folk | Show results with:folk<|control11|><|separator|>
[37]
Ganodone, a bioactive benzofuran from the fruiting bodies of ...
Extracts of Ganoderma tsugae, also known as the Hemlock varnish shelf mushroom, and related Reishi mushrooms are well documented in traditional Chinese medicine ...Missing: Taiwanese | Show results with:Taiwanese
[38]
Ganoderma lucidum and G. tsugae - Cornell Mushroom Blog
Oct 30, 2006 · As the name implies, hemlock varnish shelf, G. tsugae, prefers to grow on hemlock. Ganoderma lucidum prefers hardwood deciduous trees such as ...
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Hemlock Reishi monograph - Resilient Roots
May 21, 2025 · Traditional uses: There are no medicinal uses by indigenous peoples in America that are documented for G. tsugae; (at least none that I've found ...
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https://doi.org/10.1155/2015/754836
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https://doi.org/10.3390/biom13010024
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https://pubmed.ncbi.nlm.nih.gov/1279250/
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Cytotoxic triterpenoids from Ganoderma lucidum - PubMed
All of the compounds were assayed for their inhibitory activities against human HeLa cervical cancer cell lines. Some compounds exhibit significant ...Missing: tsugae anticancer Thai 2000s
[45]
Ganoderma: A Cancer Immunotherapy Review - Frontiers
Our results indicate that Ganoderma has a broad-spectrum application for the treatment of cancer through the regulation of the immune system.
[46]
Exploring the anti-invasive effects of Ganoderma tsugae (Songshan ...
This study examined the effects of Ganoderma tsugae extracts on lung metastatic melanoma cells in both cell culture and mouse models.Missing: macroscopic | Show results with:macroscopic
[47]
Effect of SACCHACHITIN on keratinocyte proliferation and ... - PubMed
SACCHACHITIN is a skin wound-healing membrane made of residual fruiting body of Ganoderma tsugae. Its effect on proliferating cell nuclear antigen (PCNA) ...Missing: fibroblast synthesis mouse studies 1990s
[48]
Development of fungal mycelia as a skin substitute - ResearchGate
Aug 6, 2025 · This novel wound dressing was tested on rats [56] and Guinea pigs [87], before being tested in a preliminary clinical trial on two human ...
[49]
Ganoderma tsugae prevents cognitive impairment and attenuates ...
Apr 7, 2022 · GTDE increases antioxidant capacity and BDNF expression of the brain, protects the dendritic structure of neurons, and reduces aging-induced neuronal damage.Missing: nutritional profile
[50]
Clinical Evidence for the Use of Ganoderma lucidum Medicinal ...
Jan 30, 2025 · Ganoderma lucidum contains numerous bioactive constituents, including the triterpenoid ganoderic acid, and β-glucan polysaccharide compounds.
[51]
Exploration of the anti-insomnia mechanism of Ganoderma by ...
Oct 29, 2021 · Ganoderma (Lingzhi in Chinese) has shown good clinical outcomes in the treatment of insomnia, restlessness, and palpitation.