Fact-checked by Grok 2 weeks ago

Lithotomy

Lithotomy is a surgical procedure involving the incision of an organ, most commonly the urinary bladder, to remove calculi or stones that have formed within it or other parts of the urinary tract, such as the kidneys or ureters.^[1] The term derives from the Greek words lithos (stone) and tomē (incision or cutting), reflecting its ancient origins as one of the earliest documented operations in medical history.^[1] Historically, lithotomy was a high-risk intervention performed without anesthesia, often via perineal or suprapubic approaches, and was first detailed in the 1st century AD by the Roman physician Aulus Cornelius Celsus, though evidence suggests its practice dates back to ancient civilizations including the Egyptians, Greeks, and Indians.^[2] In the Middle Ages and Renaissance, surgeons like Pierre Franco and Ambroise Paré refined techniques, but mortality rates remained high due to infection and hemorrhage, with the procedure sometimes carried out by specialized "lithotomists" or empirical practitioners.^[3] By the 19th century, advancements such as anesthesia and antisepsis improved outcomes, yet lithotomy persisted as a last-resort treatment for debilitating bladder stones, as exemplified by cases like the 1812 operation on future U.S. President James K. Polk.^[4] In modern urology, open lithotomy has largely been supplanted by minimally invasive alternatives, including extracorporeal shock wave lithotripsy (ESWL), which uses focused shock waves to fragment stones non-invasively, and endoscopic procedures like cystolitholapaxy or laser lithotripsy that allow stone removal through the urethra without large incisions.^[5] However, open cystolithotomy—incising the bladder suprapubically to extract large or multiple stones—remains relevant in specific scenarios, such as complex stone burdens in resource-limited settings or when endoscopic access is challenging, with studies indicating its use in such contexts.^[6]^[7] The procedure is typically performed under general or spinal anesthesia in the lithotomy position, where the patient lies supine with legs elevated and flexed to facilitate pelvic access, minimizing complications like nerve injury or deep vein thrombosis through careful padding and positioning.^[8] Despite these evolutions, lithotomy's legacy underscores the foundational role of stone disease in establishing urology as a distinct surgical specialty, highlighting the shift from crude, perilous operations to precise, technology-driven interventions.^[9]

Introduction

Definition and Etymology

Lithotomy is a surgical procedure involving the incision of an organ, most commonly the urinary bladder, kidney, or gallbladder, to remove calculi, which are solid masses or stones formed within these structures.^[10] This method contrasts with non-incisional techniques such as lithotripsy, which employs shock waves or lasers to fragment stones without direct cutting.^[5] The procedure has historically been essential for addressing obstructions caused by large or impacted calculi that cannot pass naturally or respond to less invasive interventions.^[11] The term "lithotomy" derives from the Greek words lithos, meaning "stone," and tomē, meaning "incision" or "cutting," reflecting the core action of surgically excising stones from the body.^[12] It was first coined in the 3rd century BC by Ammonius Lithotomos, an Alexandrian surgeon known for pioneering lithoclastic cystotomy, a technique that combined stone crushing with extraction to facilitate bladder stone removal.^[13] Urinary calculi, the primary target of lithotomy, form through the crystallization of minerals and salts in the urine, often due to supersaturation from factors such as dehydration, urinary tract infections, or underlying metabolic disorders like hypercalciuria or hyperoxaluria.^[14] This pathophysiology begins with nucleation, where crystals aggregate in the renal tubules or bladder, potentially growing into obstructive stones if not addressed; similar processes occur in biliary calculi via cholesterol or pigment precipitation in the gallbladder.^[15] Evidence of such calculi dates back to ancient Egypt, with the oldest known bladder stone discovered in a mummy dated to approximately 4900 BC.^[16]

Types of Lithotomy

Lithotomy procedures are classified primarily by the anatomical location of the calculi, with each type targeting specific organs or structures within the urinary or biliary systems. Vesicolithotomy, also known as cystolithotomy, involves the surgical removal of stones from the bladder (vesica urinaria). This approach is indicated for large or multiple bladder calculi that cannot be managed endoscopically, particularly in cases where stones exceed 3-4 cm in diameter or are associated with anatomical distortions such as diverticula.^[17] Key anatomical considerations include the bladder's capacity and distensibility, which must be assessed preoperatively to ensure adequate space for stone manipulation without risking perforation; the bladder's proximity to the pubic symphysis and peritoneal reflections also influences incision placement to minimize intraperitoneal contamination.^[17] Nephrolithotomy targets stones within the renal parenchyma or calyces, often employed for complex staghorn calculi or when percutaneous or endoscopic methods fail. Anatrophic nephrolithotomy, a subtype, involves incising the kidney along non-vascular planes to access intrarenal stones while preserving renal function. Anatomical considerations center on the renal hilum, where vascular and collecting system structures must be meticulously identified to avoid ischemia or urine extravasation; preoperative imaging, such as CT angiography, is essential to map the renal vasculature and stone burden relative to the infundibula.^[18] Pyelolithotomy addresses calculi in the renal pelvis, typically via an incision directly into this funnel-shaped structure. It is suitable for stones impacted at the pelviureteric junction or filling the pelvis without significant parenchymal extension. Critical anatomical factors include the renal pelvis's capacity, which varies with hydronephrosis, and its relationship to the ureteropelvic junction, requiring careful mobilization to prevent ureteral kinking or stricture during closure.^[18] Ureterolithotomy is performed for stones lodged in the ureter, particularly in its proximal or middle segments where endoscopic access is challenging due to impaction or tortuosity. The procedure involves longitudinal ureterotomy to extract the calculus intact. Anatomical considerations emphasize the ureter's narrow lumen (approximately 3-4 mm) and its vascular supply from multiple segmental arteries, necessitating precise incision placement parallel to the blood vessels to maintain periureteral perfusion and avoid ischemia.^[18] Cholelithotomy, less commonly performed today in favor of cholecystectomy, historically involved incision into the gallbladder to remove biliary calculi without organ excision. It may still be considered in select cases of acute cholecystitis with prohibitive surgical risk for full removal. Key anatomical aspects include the gallbladder's thin-walled fundus and its adhesion to the liver bed, requiring mobilization of the hepatobiliary triangle (Calot's triangle) to access the cystic duct and avoid injury to the common bile duct or portal triad structures.^[19] Access methods for lithotomy vary by organ and stone location, influencing incision site and potential complications. Suprapubic access, commonly used in vesicolithotomy, entails an abdominal incision above the pubic symphysis to reach the bladder dome, offering direct visualization but requiring bladder distension for safe entry.^[17] Perineal access, a historical approach for bladder stones, involves incision through the perineal floor to the prostatic urethra, suitable for smaller calculi in males but limited by risks to the rectum and neurovascular bundles.^[17] Lateral vesical access, another older technique for bladder lithotomy, involves a lateral bladder incision to approach stones from the side, reducing urethral trauma but demanding awareness of the bladder's lateral walls and adjacent pelvic vessels. For upper urinary tract procedures like nephrolithotomy or pyelolithotomy, flank or transperitoneal abdominal approaches predominate, with retroperitoneal options providing confined but bloodless access to the kidney.^[18]

Clinical Aspects

Indications

Lithotomy is primarily indicated for the management of symptomatic urinary calculi that lead to significant complications, such as obstruction resulting in acute urinary retention, recurrent urinary tract infections, gross hematuria, or progressive renal damage including hydronephrosis and impaired renal function.^[20]^[21] These symptoms arise when stones cause persistent pain unresponsive to analgesia, sepsis from infected obstruction, or bilateral renal involvement in patients with a single functioning kidney.^[20] Surgical intervention via lithotomy is warranted for stones with specific characteristics that preclude conservative measures or less invasive treatments. Open lithotomy is indicated for complex stone burdens, such as staghorn calculi or multiple stones causing anatomical distortion, particularly when endoscopic, percutaneous, or shock wave treatments are infeasible due to stone characteristics, patient anatomy, or resource limitations.^[20]^[21] Diagnosis confirming these indications typically involves non-contrast computed tomography (NCCT) or ultrasound to visualize stone presence, size, location, and associated complications like hydronephrosis or perinephric stranding, with laboratory assessment for infection or renal impairment.^[20]^[21]

Contraindications and Patient Selection

Lithotomy, the surgical removal of urinary tract stones, carries specific contraindications that must be carefully assessed to ensure patient safety. Absolute contraindications include uncorrectable coagulopathy, which poses a significant risk of uncontrolled bleeding during the procedure, as uncorrected bleeding disorders are universally recognized as prohibitive for invasive urological interventions. Active untreated urinary tract infections represent another absolute barrier, as proceeding could exacerbate sepsis or lead to severe postoperative complications. Additionally, anatomical anomalies such as severe pelvic deformities that prevent surgical access are absolute contraindications, rendering the procedure technically infeasible without excessive risk. Relative contraindications encompass factors that increase perioperative risks but may not preclude surgery entirely, depending on individual assessment. Advanced age is a relative contraindication due to heightened vulnerability to anesthesia and recovery challenges, particularly in patients over 75 years with diminished physiological reserve. Comorbidities like cardiovascular disease, including heart failure or recent myocardial infarction, are also relative, as they elevate the likelihood of hemodynamic instability under surgical stress. Furthermore, small stone sizes (typically under 1 cm) amenable to less invasive alternatives, such as extracorporeal shock wave lithotripsy, serve as a relative contraindication to surgical lithotomy, favoring conservative or minimally invasive options to minimize morbidity. Patient selection for lithotomy involves a structured multidisciplinary evaluation to balance benefits against risks. This process begins with a comprehensive urologist-led assessment, incorporating imaging to confirm stone characteristics and rule out contraindications. Laboratory tests, including a full coagulation profile (e.g., prothrombin time, international normalized ratio, and platelet count), are essential to identify and mitigate bleeding risks prior to proceeding. Informed consent is a critical component, where patients are educated on procedure-specific risks, alternatives, and expected outcomes to ensure shared decision-making.

Surgical Procedure

Preoperative Evaluation

Preoperative evaluation for lithotomy involves a systematic assessment to ensure patient safety, optimize surgical outcomes, and minimize complications associated with urinary stone removal. This process begins with a thorough review of the patient's medical history and physical examination to identify comorbidities, such as renal impairment or active urinary tract infections, that could influence procedural risks.^[22]^[23] Diagnostic imaging plays a central role in mapping stone characteristics prior to lithotomy. Non-contrast-enhanced computed tomography (CT) is the gold standard for confirming stone location, size, and number, providing detailed three-dimensional visualization of the urinary tract anatomy to guide surgical planning, particularly for complex or large stones requiring open access.^[22]^[23] Ultrasound serves as an effective alternative, especially for bladder stones or in patients where radiation exposure must be minimized, such as pregnant individuals, offering real-time assessment of stone burden and hydronephrosis without ionizing radiation.^[22] In cases of suspected renal functional compromise, functional imaging like diethylenetriamine pentaacetic acid (DTPA) or mercaptoacetyltriglycine (MAG-3) renography may be employed to evaluate differential kidney function.^[23] Laboratory testing is essential to assess infection risk, renal function, and overall physiological status. Urinalysis, including dipstick testing for pH, nitrites, leukocytes, and microscopy, is routinely performed to detect bacteriuria or crystalluria, with urine culture and sensitivity testing recommended if infection is suspected to identify pathogens and guide targeted therapy.^[22]^[23] Blood work typically includes a complete blood count to evaluate for anemia or infection, serum creatinine and electrolytes (sodium, potassium) to assess renal function and hydration status, as well as calcium, uric acid, and C-reactive protein (CRP) to inform stone etiology and inflammatory markers.^[22]^[23] For patients with suspected coagulopathy or those on antithrombotic therapy, coagulation profiles and platelet counts are obtained to mitigate bleeding risks during open procedures.^[24] Patient optimization focuses on reducing perioperative risks through targeted interventions. Antibiotic prophylaxis is strongly recommended for all endourological and open stone removal procedures, with a single intraoperative dose (e.g., cephalosporin or fluoroquinolone) sufficient for low-risk cases, while extended courses (up to 24-72 hours) are advised for high-risk patients with positive urine cultures, indwelling stents, or infection stones to prevent postoperative sepsis.^[22]^[24] Adequate hydration is encouraged preoperatively, aiming for a urine output of at least 2-2.5 liters per day through oral or intravenous fluids, to enhance renal perfusion, facilitate stone visualization, and reduce the viscosity of urine that could obscure calculi during surgery.^[22] For procedures involving abdominal access, such as suprapubic lithotomy, mechanical bowel preparation with enemas or laxatives may be utilized to decompress the bowel and minimize the risk of inadvertent injury, though it is not routinely required for all stone surgeries.^[24] These measures collectively prepare the patient for safe incision and stone extraction while addressing potential complications like infection or obstruction.^[22]

Operative Techniques

Lithotomy procedures for urinary tract stones typically begin with anesthesia, most commonly general or spinal, to ensure patient comfort and immobility during the operation.^[25] The patient is positioned in the lithotomy or supine position with legs elevated or supported, facilitating access to the perineum, urethra, or lower abdomen depending on the approach. Preoperative imaging, such as ultrasound or X-ray, may guide stone localization but is not part of the operative execution itself. Instruments commonly include cystoscopes, forceps, lithotrites for crushing, and irrigation systems to maintain visibility and remove debris. In the suprapubic cystolithotomy approach, used for larger bladder stones, a lower midline or Pfannenstiel incision is made above the pubic symphysis to access the bladder. The linea alba is incised, followed by blunt dissection into the retropubic space (cavum Retzii), and a wound retractor is inserted for exposure. Stay sutures are placed on the bladder dome, which is then opened vertically to reveal the stone; extraction occurs using forceps or scoops, with irrigation to clear fragments and ensure complete removal. Hemostasis is achieved by controlling bleeding points, and the bladder is closed in two layers (mucosa and muscularis) with absorbable sutures, followed by drainage of the retropubic space and layered abdominal closure.^[26] The perineal approach, historically favored for bladder stones to avoid abdominal entry, involves positioning the patient with knees flexed toward the chest. A vertical or oblique incision is made in the perineum, typically 2-4 inches long to the left of the median raphe, guided by a grooved staff inserted into the urethra to locate the stone near the bladder neck. The incision extends through the prostate and membranous urethra into the bladder, using a gorget or dilator for controlled entry; the stone is immobilized with a finger via the rectum or sound and extracted with duck-bill forceps, scoops, or crochets, often after crushing larger calculi with lithotomes. The wound is left open to drain without formal closure to minimize infection risk.^[3] For renal stones requiring open surgery, such as in cases of complex staghorn calculi or failed minimally invasive attempts, pyelolithotomy or nephrolithotomy is performed via a flank or subcostal incision to access the kidney. The renal pelvis or calyces are incised longitudinally, often using an avascular plane (anatrophic nephrolithotomy) to minimize bleeding, allowing direct extraction of stones with forceps or irrigation. The collecting system is closed with fine absorbable sutures, and a nephrostomy tube or drain is placed for postoperative drainage, followed by layered closure of the renal capsule and abdominal wall.^[27] For impacted ureteral stones, open ureterolithotomy involves a lumbar (upper ureter) or iliac (lower ureter) incision to expose the ureter. The ureter is mobilized, incised longitudinally over the stone under direct vision, and the calculus is extracted. The ureterotomy is closed with fine interrupted absorbable sutures (e.g., 5-0 or 6-0), often over a placed double-J stent to maintain patency and prevent stricture, with drains if necessary and layered wound closure.^[28]

Postoperative Management

Following lithotomy surgery for urinary stones, immediate postoperative care focuses on stabilizing the patient, managing pain, and ensuring adequate urinary drainage. Patients typically receive intravenous fluids to maintain hydration and support renal function, alongside continuous monitoring of vital signs such as blood pressure, heart rate, and oxygen saturation in the recovery room.^[29] Pain control is achieved through multimodal analgesia, including non-opioid analgesics like acetaminophen or nonsteroidal anti-inflammatory drugs, and opioids if necessary, to address incisional, visceral, or stent-related discomfort.^[30] A urinary catheter or nephrostomy tube is routinely placed to facilitate bladder or kidney drainage and monitor urine output, which should be at least 0.5 mL/kg/hour to confirm adequate renal perfusion.^[23] Monitoring protocols emphasize early detection of potential issues, with serial laboratory assessments including complete blood count and electrolytes to evaluate for anemia from bleeding or electrolyte imbalances from fluid shifts.^[30] Imaging, such as ultrasound or plain radiography, may be performed if gross hematuria persists or fever develops, to rule out hematoma formation or residual fragments.^[29] Patients are observed for signs of infection, including fever above 38°C or chills, prompting urine cultures and antibiotic administration if indicated. For open procedures, a nephrostomy or drainage tube may remain in place for several days to allow healing, while ureteral stents, if used, are typically removed 4-6 weeks postoperatively.^[23] Discharge criteria generally include stable vital signs, ability to ambulate independently, resumption of normal oral intake, and demonstration of adequate voiding without significant retention or hematuria.^[31] For open cystolithotomy, suprapubic catheter drainage is continued for 1-2 days before removal, with hospital stays averaging 4-5 days in uncomplicated cases.^[32] Follow-up appointments are scheduled 1-2 weeks post-discharge for wound inspection and to assess recovery, with instructions to avoid strenuous activity for 2-4 weeks to prevent wound dehiscence.^[29]

Historical Development

Ancient Origins

The earliest documented evidence of bladder stones dates to ancient Egypt, where a calculus was discovered in the pelvis of a mummy from El Amrah, estimated to be around 4800 BC.^[16] This finding, unearthed by archaeologist E. Smith in 1901 after examining thousands of mummies, underscores the prevalence of urolithiasis in early civilizations, likely exacerbated by dietary factors such as high grain consumption.^[16] Ancient Egyptian medical texts, including the Ebers Papyrus from approximately 1550 BC, reference treatments for urinary tract disorders involving stones, emphasizing pharmacological remedies like incantations, suppositories, and herbal infusions to alleviate symptoms, though surgical interventions were rudimentary and not explicitly detailed.^[33] In ancient India, significant advancements in lithotomy emerged with the Sushruta Samhita, composed around 600 BC by the surgeon Sushruta. This foundational Ayurvedic text provides one of the earliest detailed descriptions of perineal lithotomy, a procedure involving a lateral incision through the perineum to access and extract bladder stones, performed with specialized instruments like hooks and forceps.^[34] Sushruta advocated for preoperative preparation, including patient positioning in a flexed posture to facilitate access, and employed herbal anesthetics such as wine infused with cannabis and opium to induce sedation and reduce pain during the operation.^[35] These techniques highlighted a systematic approach to surgery, prioritizing wound management and postoperative care to mitigate infection risks in an era without modern antisepsis. Greek medical literature further developed lithotomy practices, with the Hippocratic Corpus (c. 400 BC) acknowledging bladder stones as a common affliction and describing conservative management alongside warnings against invasive procedures by general physicians.^[36] The texts imply that perineal approaches were known but risky, as the Hippocratic Oath explicitly prohibited practitioners from "cutting for the stone," reserving it for specialized surgeons due to high mortality from hemorrhage or infection.^[37] A key innovation came from Ammonius of Alexandria around 200 BC, who invented the first lithoclastic instrument—a hooked device to crush large stones into smaller fragments before perineal extraction—earning him the epithet Lithotomus and marking an early shift toward less traumatic methods.^[38] This tool, as later described by the Roman encyclopedist Aulus Cornelius Celsus (c. 25 BC–50 AD) in his work De Medicina, stabilized the stone for fragmentation, reducing the incision size and operative complications. Celsus provided the first detailed account of perineal lithotomy, including the "apparatus minor" technique with a curved incision, finger guidance to avoid rectal injury, and extraction using forceps, while also noting risks like hemorrhage and emphasizing the need for experienced operators.^[16]^[39]

Medieval and Early Modern Periods

During the Medieval period in Europe, spanning roughly from the 11th to the 15th century, lithotomy was primarily performed by itinerant practitioners known as "cutters for the stone," who traveled from town to town offering their services to remove bladder calculi. These surgeons, often lacking formal medical education and operating as showmen, conducted perineal lithotomy procedures publicly without anesthesia, making a deep incision in the perineum to access and extract the stone. The technique, which built upon ancient Greco-Roman methods described by figures like Celsus, carried significant risks due to infection, hemorrhage, and poor postoperative care, though specific mortality figures from this era are not well-documented. These traveling lithotomists were sometimes held accountable by local authorities for unsuccessful outcomes, facing fines or expulsion, which underscored the procedure's precarious reputation.^[16] In the Islamic Golden Age, particularly in the 10th and 11th centuries, advancements in lithotomy were pioneered by Abū al-Qāsim al-Zahrāwī (Albucasis, c. 936–1013 AD) in Córdoba, whose comprehensive surgical treatise Al-Tasrīf detailed refined perineal cystolithotomy techniques that influenced European practice for centuries. Albucasis advocated a lateral perineal incision to avoid damaging the rectum, introduced a specialized double-edged scalpel called the "nechil" for precise cutting, and developed forceps (al-kalālīb) to grasp and remove stones, reducing the need for blind finger extraction. For complex cases involving large or impacted stones, he recommended a two-stage operation, and while he is renowned for innovating catgut sutures from sheep intestines for wound closure in various surgeries—including potentially lithotomy incisions—his emphasis was on minimizing trauma and promoting healing through meticulous instrumentation. These innovations marked a shift toward more systematic and less barbaric approaches compared to earlier perineal methods.^[40]^[16]^[41] The Renaissance brought further refinements to lithotomy in Europe, with Pierre Franco (c. 1505–1578), a French barber-surgeon from Lausanne, pioneering the "high" or suprapubic approach in 1561 after a failed perineal attempt on a two-year-old child with a large bladder stone. In this technique, Franco made an incision above the pubic symphysis to directly access the bladder, successfully extracting the calculus and demonstrating its feasibility for cases where perineal access was inadequate, though it required careful bladder distension and carried risks of urinary extravasation. These early modern innovations laid the groundwork for safer stone removal, bridging medieval empiricism with more anatomically informed practices.^[42]^[43]

19th and 20th Century Advances

In the 18th century, significant advancements in lithotomy techniques emerged, particularly through the work of English surgeon William Cheselden, who pioneered the lateral vesical lithotomy in 1727. This method involved a precise perineal incision to access the bladder, allowing for rapid stone extraction and marking a departure from the more invasive and time-consuming medieval approaches. Cheselden's procedure dramatically reduced operative time to under one minute and achieved a mortality rate of less than 10% across 213 cases, a substantial improvement over prior methods that often exceeded 20-50% fatality due to prolonged exposure and hemorrhage.^[44] The 19th century brought further innovations, shifting toward less traumatic options with the introduction of Jean Civiale's transurethral lithotripsy in the 1820s. Civiale, a French urologist, developed the lithotrite, an instrument inserted through the urethra to mechanically crush bladder stones into fragments that could pass naturally, first successfully applied in a human patient on January 13, 1824.^[45]^[46] This "blind" procedure, reported to the Academy of Sciences in 1824, offered a minimally invasive alternative to open surgery, with statistical evidence from Civiale demonstrating lower mortality compared to traditional lithotomy. Concurrently, refinements in the high suprapubic method—approaching the bladder via an abdominal incision above the pubic bone—gained traction, particularly after the advent of general anesthesia in the 1840s, enabling safer access for larger stones unsuitable for crushing.^[47] By the 20th century, open lithotomy began to decline as supportive medical advancements and novel therapies reduced its necessity. The introduction of antibiotics in the mid-20th century, building on earlier antisepsis principles, drastically lowered postoperative infection rates—previously a leading cause of mortality at up to 50%—by enabling effective prophylaxis and treatment of urinary tract complications. This was compounded by the advent of extracorporeal shock wave lithotripsy (ESWL) in the 1980s, which used focused shock waves to fragment stones noninvasively; the first human kidney stone treatment occurred in 1980, rendering open procedures rare for most cases by providing stone-free rates over 80% for stones under 2 cm with minimal complications.^[42]

Complications and Outcomes

Immediate Complications

Immediate complications of lithotomy surgery for bladder stones primarily arise during the intraoperative phase or within the first few days postoperatively. Intraoperative risks include hemorrhage due to vascular injury during bladder incision or stone manipulation, which may necessitate transfusion or additional hemostatic measures. Bladder perforation is another potential issue, particularly in suprapubic approaches where the bladder wall is incised, though it is rare with experienced surgeons. Anesthesia-related complications, such as cardiovascular instability or respiratory issues, can also occur, especially in patients with comorbidities undergoing general anesthesia. In a comparative study of 37 open cystolithotomy cases, intraoperative bleeding affected 5.4% of patients, with no reported perforations.^[48] Early postoperative complications often involve infection and urinary issues. Urinary tract infection (UTI) is the most frequent, occurring due to bacterial introduction during surgery or from indwelling catheters, with rates up to 13.5% in open procedures. Wound dehiscence may develop at the suprapubic incision site from poor healing or tension, while acute urinary retention can result from postoperative edema or clot formation obstructing the urethra. In the same study, postoperative UTI was observed in 13.5% of open cystolithotomy patients, alongside rare instances of wound-related issues.^[48]^[49] Historically, lithotomy carried high mortality rates of up to 25-50% in the pre-antibiotic era, largely from sepsis and hemorrhage following perineal or suprapubic approaches.^[50] Modern sterile techniques, antibiotics, and refined surgical methods have dramatically reduced these risks, with overall complication rates typically 10-30% in contemporary series and mortality approaching zero in uncomplicated cases. The European Association of Urology guidelines emphasize that while open lithotomy remains effective for large stones, its immediate risks are higher than minimally invasive alternatives due to increased bleeding and infection potential.^[31]

Long-term Effects

Lithotomy surgery, particularly the historical perineal approach, carries risks of long-term urological sequelae due to potential damage to the external urethral sphincter and surrounding nerves. Urinary incontinence was a frequent complication following perineal lithotomy, often resulting from sphincter injury during stone extraction through the perineum.^[51] Similarly, erectile dysfunction occurred as a common sequela in male patients undergoing perineal procedures, attributed to trauma to the cavernous nerves and vascular structures in the pelvic floor.^[51] These issues were particularly prevalent in pre-modern eras when instrumentation was crude and anatomical knowledge limited, leading to persistent quality-of-life impairments, with incontinence affecting a notable proportion in early perineal cases. In contemporary practice, suprapubic lithotomy has largely supplanted perineal methods, minimizing sphincter and nerve damage, though rare cases of urinary incontinence may still arise from postoperative inflammation or scarring. Modern techniques report lower rates of erectile dysfunction, typically under 5%, with most cases resolving within months. Recurrent stone formation remains a key long-term concern, driven by underlying etiologies such as neurogenic bladder or urinary stasis; without targeted management like intermittent catheterization or medical therapy, recurrence rates can reach 20-50% over 5 years in high-risk cohorts.^[31] Systemic impacts of lithotomy extend beyond the urogenital tract, with prior chronic bladder outlet obstruction from stones potentially causing irreversible upper urinary tract damage and progression to chronic kidney disease through hydronephrosis and renal parenchymal atrophy. Adhesions formed during open suprapubic approaches can lead to chronic bowel complications, including small bowel obstruction, which occurs in approximately 3-5% of patients after abdominal surgery and may require adhesiolysis.^[52] These effects underscore the importance of preoperative assessment of obstruction duration and postoperative adhesion prevention strategies. Outcomes data from historical series indicate a substantial burden, contrasting sharply with modern refined techniques, where such risks have dropped due to improved imaging, minimally invasive adjuncts, and sphincter-sparing approaches. Overall, long-term morbidity has declined with advancements, but vigilant follow-up for recurrence and renal function is essential to optimize patient health.

Modern Alternatives

Lithotripsy and Non-invasive Methods

Lithotripsy represents a pivotal advancement in the management of urinary tract stones, shifting treatment paradigms from invasive surgical interventions to non-invasive techniques in the early 1980s.^[53] Extracorporeal shock wave lithotripsy (ESWL), the cornerstone of these methods, employs focused acoustic shock waves to fragment calculi externally, allowing natural passage through the urinary tract without incisions.^[54] First approved by the U.S. Food and Drug Administration in 1984, ESWL has become a standard outpatient procedure for suitable stone cases, typically completed under sedation in 45-60 minutes.^[53] The mechanism of ESWL involves generating high-energy shock waves that propagate through the patient's body to the targeted stone. These waves are produced by electromagnetic, piezoelectric, or electrohydraulic sources: electromagnetic systems use a coil to create a magnetic field that accelerates a metal plate, generating waves upon impact; piezoelectric sources employ ceramic crystals that deform under voltage to emit waves over a broad surface; and electrohydraulic methods spark an underwater electrode to produce waves via plasma formation.^[55] Upon reaching the stone, the waves induce fragmentation through mechanisms such as cavitation (bubble collapse creating microjets), spallation (internal reflection causing tensile stress), and shear forces, breaking the calculus into passable fragments.^[53] Fluoroscopy or ultrasound guides precise targeting, with 3000-4000 shocks delivered per session at energies up to 0.25 mJ/mm².^[53] ESWL is primarily indicated for stones in the upper urinary tract, including renal calculi under 2 cm and proximal ureteral stones, particularly those causing persistent colic or obstruction.^[53] It is most effective for radiopaque stones in the renal pelvis or upper calyces, with success defined as stone-free status (fragments <4 mm) within 3 months post-treatment.^[56] For kidney stones smaller than 2 cm, stone-free rates range from 70% to 90%, often achieved in a single session, though multiple treatments may be needed for optimal clearance.^[56] Despite its advantages, ESWL has notable limitations and potential side effects. It is less suitable for stones exceeding 2 cm, lower pole calyceal calculi over 10 mm, radiolucent stones, or those with density above 1000 Hounsfield units, as these resist fragmentation and increase retreatment rates.^[53] Contraindications include pregnancy, untreated coagulopathies, active urinary tract infections, and severe skeletal malformations obstructing the shock wave path.^[53] Common adverse effects encompass self-limited hematuria (nearly universal), post-procedural renal colic in about 40% of cases, perirenal hematomas in 1-4.6%, and steinstrasse (fragment obstruction) in up to 3%, with infection risks around 10% if bacteremia is present.^[53] Overall, ESWL's non-invasive nature minimizes recovery time compared to historical surgical approaches, though patient selection remains critical for efficacy.^[57]

Endoscopic and Minimally Invasive Procedures

Endoscopic and minimally invasive procedures for stone removal represent a significant advancement in urolithiasis management, utilizing internal visualization and instrumentation to fragment and extract calculi with reduced tissue trauma compared to traditional open surgery. These techniques, performed under imaging guidance and anesthesia, access the urinary tract through natural orifices or small percutaneous incisions, enabling high efficacy while minimizing recovery time and complications. They have become the preferred approaches for most renal, ureteral, and bladder stones, reserving open lithotomy for rare complex cases where endoscopic access is infeasible. For bladder stones, transurethral cystolitholapaxy is the standard endoscopic alternative to open cystolithotomy, involving the insertion of a cystoscope through the urethra to mechanically crush or laser-fragment stones, followed by irrigation and evacuation. This procedure achieves stone-free rates of 90-100% for stones up to 4 cm, with low complication rates (around 5-10%), including transient hematuria and infection, and allows same-day discharge in many cases.^[58] Percutaneous cystolithotomy, using a suprapubic approach with ultrasound guidance, is suitable for larger stones (>4 cm) or in patients with urethral strictures, offering similar efficacy with reduced operative time compared to open surgery.^[17] Ureteroscopy involves inserting a flexible or rigid endoscope through the urethra and bladder into the ureter, allowing direct visualization of stones.^[59] The procedure typically employs a holmium laser to fragment calculi into passable pieces, followed by basket extraction of larger fragments, achieving stone-free rates exceeding 95% for ureteral stones, particularly those in the distal ureter. Complications are low, with an overall rate of approximately 3.5%, primarily minor issues such as mucosal injury or transient hematuria.^[59] Percutaneous nephrolithotomy (PCNL) is indicated for larger renal stones, typically greater than 2 cm, where ureteroscopy may be less effective.^[60] Under fluoroscopic or ultrasonic guidance, a needle is inserted through a small back incision into the kidney's collecting system, dilating a tract for nephroscope access to fragment and remove stones using laser or pneumatic lithotripsy.^[60] Success rates range from 75% to 98%, with stone clearance often exceeding 90% in a single session for complex renal calculi.^[60] Compared to open surgery, PCNL offers lower morbidity, shorter hospitalization, and faster recovery, typically 2-4 weeks.^[60] The evolution of these transurethral methods traces back to Jean Civiale's introduction of blind lithotripsy in 1824 using a lithotrite instrument, marking an early shift toward less invasive stone crushing via the urethra.^[45] Modern refinements, including fiberoptic visualization since the 1980s and advanced laser technology, have transformed these into standard first-line treatments, with open lithotomy now limited to failures or anatomically challenging cases due to the superior outcomes of endoscopic approaches.^[59]^[61]

References

[1]
LITHOTOMY Definition & Meaning - Merriam-Webster
The meaning of LITHOTOMY is surgical incision of the urinary bladder for removal of a stone.
[2]
The Operation of Lithotomy in Ancient Greece - PubMed
The technique of lithotomy was described for the first time by Celsus in the first century AD and has come to be known as the lesser operation or 'apparatus ...<|control11|><|separator|>
[3]
[PDF] The History of Lithotomy and Lithotrity
Both Home and Brodie used a three-bladed forceps for lithotomy and Aston Key had one with four blades. The high operation. The Hippocratic veto that wounds in ...Missing: definition | Show results with:definition
[4]
The Case Report of James K. Polk's Bladder Stone
Jan 23, 2025 · In 1812 James K. Polk underwent a lithotomy procedure by Dr. Ephraim McDowell of Kentucky to remove a bladder.Missing: definition | Show results with:definition<|control11|><|separator|>
[5]
Lithotripsy | Johns Hopkins Medicine
Lithotripsy is a noninvasive (the skin is not pierced) procedure used to treat kidney stones that are too large to pass through the urinary tract.About Kidney Stones · Urinary System Parts And... · During The ProcedureMissing: modern lithotomy
[6]
Open stone surgery: a still-in-use approach for complex stone burden
Open surgery for most urinary stones currently holds only a historical importance. However, mainly in endemic areas, urologists still faced patients with ...
[7]
Cystolithotomy | Radiology Reference Article | Radiopaedia.org
Feb 8, 2025 · The open procedure involves incising the bladder and removing the bladder stones. It can either be performed as a single procedure or as ...
[8]
Lithotomy - an overview | ScienceDirect Topics
The lithotomy position is frequently used for transurethral procedures or open surgeries requiring access to the perineum, proximal urethra, or anus. Before ...
[9]
Bladder stones and lithotomy: A vanished ailment as the basis of ...
Aug 9, 2025 · The practice of open lithotomy ceased to exist owing to better minimally invasive alternative methods and most notably by the virtual ...
[10]
LITHOTOMY | definition in the Cambridge English Dictionary
Oct 29, 2025 · a medical operation to remove a stone from the bladder, kidney, or gall bladder: Now that a lithotripter is so widely used, it is more difficult ...
[11]
Lithotomy – Knowledge and References - Taylor & Francis
The term comes from the Greek words lithos, meaning stone, and tome, meaning cutting.From: A Dictionary of the History of Medicine [2018]. more. Related ...
[12]
Lithotomy - Etymology, Origin & Meaning
Originating from Greek lithotomia meaning "place where stone is cut," lithotomy means the operation of cutting out a bladder stone, combining litho- "stone" ...Missing: medical | Show results with:medical
[13]
Ammonius Lithotomos (3rd Century BC), the Alexandrian ... - PubMed
Alexandrian surgeon Ammonius Lithotomos, was the first to introduce lithoclastic cystotomy during the 3rd century BC in order to relieve a bladder's stone ...Missing: etymology | Show results with:etymology
[14]
Kidney stones - Symptoms and causes - Mayo Clinic
Apr 4, 2025 · Kidney stones develop when the urine contains more crystal-forming substances than the fluid in the urine can dilute. These substances ...
[15]
Renal Calculi, Nephrolithiasis - StatPearls - NCBI Bookshelf - NIH
Low urinary volume due to inadequate fluid intake leads to relative dehydration with increased urinary concentrations and crystal formation. [28] Urinary tract ...Continuing Education Activity · Etiology · Epidemiology · Pathophysiology
[16]
The History of Urinary Stones: In Parallel with Civilization - PMC - NIH
Smith found a bladder stone from a 4500–5000-year-old mummy in El Amrah, Egypt. Treatments for stones were mentioned in ancient Egyptian medical writings from ...
[17]
Bladder Stones Treatment & Management - Medscape Reference
Nov 3, 2023 · Bladder (vesical) calculi are stones or calcified materials that are present in the bladder (or in a bladder substitute that functions as a ...Missing: definition | Show results with:definition
[18]
Pyelolithotomy, ureterolithotomy, and anatrophic nephrolithotomy
Aug 8, 2022 · Laparoscopic or robotic-assisted pyelolithotomy, ureterolithotomy, and anatrophic nephrolithotomy have the same indications as open treatment and have largely ...
[19]
Laparoscopic Cholecystectomy - StatPearls - NCBI Bookshelf - NIH
Jul 2, 2025 · Laparoscopic cholecystectomy is a minimally invasive surgical technique used to remove a diseased gallbladder.
[20]
EAU Guidelines on Urolithiasis - European Association of Urology
If analgesia cannot be achieved medically, drainage, using stenting, percutaneous nephrostomy, or stone removal, is indicated [109]. 3.4.1.1. Summary of ...
[21]
Nephrolithiasis Treatment & Management - Medscape Reference
Jun 5, 2025 · Larger stones (ie, ≥7 mm) that are unlikely to pass spontaneously require some type of surgical procedure. In some cases, hospitalizing a ...<|separator|>
[22]
EAU Guidelines on Urolithiasis - BLADDER STONES
The symptoms are most associated with bladder stones are urinary ... Suggest open cystolithotomy as an option for very large bladder stones in adults and children ...
[23]
Guidelines for the Clinical Application of Laparoscopic Biliary Tract ...
Laparoscopic cholecystectomy provides a safe and effective treatment for most patients with symptomatic gallstones.
[24]
EAU Guidelines on Urolithiasis - INTRODUCTION
These guidelines to help urologists assess evidence-based management of stones/calculi in the urinary tract and incorporate recommendations into clinical ...Guidelines · Follow Up Of Urinary Stones · Metabolic Evaluation And... · MethodsMissing: preoperative | Show results with:preoperative
[25]
Kidney Stones: Surgical Management Guideline
The purpose of this clinical guideline is to provide a clinical framework for the surgical management of patients with kidney and/or ureteral stones.
[26]
Pre-Operative Care for the Patient Undergoing Urologic Surgery or ...
For example, patients being positioned dorsal lithotomy should have lower extremity range of motion. Flank, supine, and prone positioning can also be similarly ...
[27]
Transurethral Cystolithotripsy of Large Bladder Stones by Holmium ...
Transurethral holmium laser lithotripsy is an effective and safe procedure for large bladder stones. This procedure can be easily performed as a day care ...Missing: steps | Show results with:steps
[28]
Cystolithotomy: Technique and Complications of Sectio Alta
Cystolithotomy (sectio alta) is the surgical removal of bladder stones via a lower abdominal incision. The term sectio alta refers to the historical techniques ...
[29]
Percutaneous nephrolithotomy - Mayo Clinic
Nov 19, 2024 · A procedure used to remove kidney stones from the body when they can't pass on their own. "Percutaneous" means through the skin.
[30]
Surgical management of kidney and ureteral stones - UpToDate
Aug 12, 2024 · PREOPERATIVE EVALUATION · Laboratory testing · Preoperative imaging ... (See "Kidney stones in adults: Evaluation of the patient with established ...Missing: lithotomy | Show results with:lithotomy
[31]
History, epidemiology and regional diversities of urolithiasis - PMC
Regimens for treatment of diseases of the urinary tract, including stones, had already been found in the papyrus Ebers (1500 BC), being the main origin of our ...
[32]
History of Renal Stone Surgery: A Narrative Review | Cureus
Nov 26, 2024 · Perineal lithotomy. The earliest description of a surgical approach for removing bladder stones dates back to 600 BC [7]. Sushruta, a surgeon ...
[33]
Sushruta: The Father of Surgery and Ancient Medical Innovations
Sep 30, 2024 · Sushruta's approach to anaesthesia, although not as advanced as modern techniques, was innovative. He used herbal anaesthetics such as opium ( ...
[34]
Hippocrates and urology: The first surgical subspecialty
The pivotal point of the Hippocratic corpus was the Hippocratic Oath, which outlined the duties of healers of his school, but demarcated lithotomy as a ...Missing: procedure | Show results with:procedure
[35]
The prohibition of lithotomy within the Hippocratic Oath - PubMed
The prohibition of lithotomy could be interpreted as a commitment to realize the limits of ones own medical actions.Missing: texts suprapubic
[36]
Lithotripsy: a historical review - Hektoen International
Jan 29, 2017 · Considered by Celsus as the originator of the technique of crushing a bladder stone before removing it, Ammonius was given the surname of ...Missing: lithotomy etymology
[37]
Extraction of urinary bladder stone as described by Abul-Qasim ...
This is a detailed study of the technique of cystolithotomy as practiced by the Muslim surgeon Alzahrawi (Albucasis) in Cordova more than 1000 years ago.Missing: lithotomy | Show results with:lithotomy
[38]
The History of Urinary Stones: In Parallel with Civilization - Tefekli
Nov 20, 2013 · The first recorded details of “perineal lithotomy” were those of Cornelius Celsus. Ancient Arabic medicine was based mainly on classical Greco- ...
[39]
History of Renal Stone Surgery: A Narrative Review - PMC
Nov 26, 2024 · This review explores the origins and major developments in surgical techniques for renal stones, enhancing our understanding of how modern procedures have ...
[40]
The High Operation - Urology News
Sep 1, 2014 · From Hippocrates onwards all knew that abdominal wounds of the bladder were fatal. ... suprapubic lithotomy. He removed a stone from the bladder ...Missing: texts | Show results with:texts
[41]
William Cheselden, father of modern British surgery
Mar 30, 2020 · He began his career by focusing on the surgical removal of urinary bladder stones and in 1723 he published a treatise on that subject.Missing: vesical | Show results with:vesical
[42]
Exhibit of the Month: The Civiale Set - Uroweb
In 1824, Jean Civiale (1792–1867), a French proto-urologist ... transurethral lithotripsy, which was later called the first minimally invasive procedure.Missing: 1820s | Show results with:1820s
[43]
Suprapubic Lithotomy - EAU European Museum of Urology
This operation was for the removal of a stone the size of a hen's egg in the bladder of a two-year-old child.Missing: Hippocratic texts<|separator|>
[44]
https://hekint.org/2020/03/30/william-cheselden-father-of-modern-british-surgery/
[45]
Bladder stones - Treatment - NHS
Complications of surgery. The most common complication of bladder stone surgery is infection of the bladder or urethra, known as a urinary tract infection (UTI) ...Transurethral... · Open Cystostomy · Neurogenic BladderMissing: lithotomy | Show results with:lithotomy
[46]
Commentary: Treatment of bladder stones and probabilistic ...
Lithotomy, or 'stone cutting' via the perineal route was the treatment of last recourse before the 1800s—a gruesome procedure with high mortality. The history ...<|control11|><|separator|>
[47]
Marian Method (Apparatus Major)
The Marian operation was more suited for adults as the transverse perineal muscle was not cut and the ischio-rectal fossa not opened.
[48]
Adhesive Small Bowel Obstruction: A Review - PMC - NIH
Apr 30, 2023 · The surgery itself can cause new adhesion formation with approximately 10% to 30% requiring another laparotomy for recurrent bowel obstruction.Missing: suprapubic lithotomy
[49]
[PDF] A Brief History of Urinary Incontinence and its Treatment
In later centuries several authors dealt with the problem of postoperative incontinence after perineal lithotomy. Defined surgical techniques for the cure of ...
[50]
Extracorporeal Shockwave Lithotripsy - StatPearls - NCBI Bookshelf
ESWL is contraindicated in pregnancy, active anticoagulation, severe or poorly controlled hypertension, aortic aneurysms in the therapy or blast path, and ...
[51]
Extracorporeal Shock Wave Lithotripsy (ESWL) - UF Urology
Extracorporeal shock wave lithotripsy (ESWL) was introduced in the early 1980s as a completely noninvasive therapy to break up stones within the kidney and ...Missing: mechanism | Show results with:mechanism
[52]
Optimisation of shock wave lithotripsy: a systematic review of ...
There are currently four types of shock wave generation: electrohydraulic, electromagnetic, and piezoelectric. Electrohydraulic generators generate shock ...
[53]
Impact of advanced lithotripter technology on SWL success - NIH
Feb 25, 2025 · Reported studies have shown that the success rates for stones smaller than 2 cm range between 70 and 90% [9]. However, the effectiveness ...
[54]
[PDF] Current Perspective on Adverse Effects in Shock Wave Lithotripsy
In summary, the advantages of SWL include its noninvasive nature, the fact that it is technically easy to treat most upper urinary tract calculi and that, at ...
[55]
Ureteroscopy and stones: Current status and future expectations - NIH
The overall complication rate for URS is approximately 3.5%; which are mostly minor. Probably the most feared complication of ureteroscopy is ureteral avulsion ...
[56]
Percutaneous Nephrolithotomy: Procedure, Risks & Recovery
Percutaneous nephrolithotomy is a surgical procedure to remove kidney stones that are too large to pass on their own or don't respond to other treatments.
[57]
The role of open stone surgery - PMC - NIH
Laparoscopic surgery has recently emerged as a reliable alternative to open stone surgery, because calculi can be removed from almost all locations in the ...