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Raphe

A raphe is a seam, ridge, or furrow marking the line of union or fusion of two similar parts, commonly used in biology and anatomy to describe such structures.^[1] In anatomy, it often indicates the midline union of bilateral embryonic tissues, appearing as a crease, ridge, or seam on organs or tissues.^[2] The term derives from the Greek rhaphe (ῥαφή), meaning "suture" or "seam."^[2] In human anatomy, prominent examples include the perineal raphe, a ridge extending from the anus through the perineum to the genitalia, formed by the embryological fusion of the urogenital folds—in males continuing as the scrotal and penile raphes, and in females to the posterior labia minora.^[3] The pterygomandibular raphe is a tendinous band in the oral cavity linking the buccinator and superior pharyngeal constrictor muscles, serving as a key landmark in dental procedures due to its attachments and morphological variability.^[4] The palatine raphe is a midline ridge along the hard palate.^[2] In neuroanatomy, the raphe nuclei are midline brainstem structures spanning the midbrain, pons, and medulla oblongata, comprising mainly serotonergic neurons that project to influence mood, sleep, appetite, and pain.^[5] The dorsal raphe nucleus, the largest such cluster, is central to serotonin systems and linked to disorders like depression and anxiety.^[5] Beyond human anatomy, raphes appear in botany as ridges in seeds or ovules and in diatoms as elongated slits, underscoring the term's role in describing developmental fusions across organisms.^[6] Thus, raphes highlight midline structures of developmental and functional importance in biology.

Etymology and Definition

Etymology

The term "raphe" originates from the Ancient Greek word ῥαφή (rhaphḗ), meaning "seam" or "suture," derived from the verb ῥάπτειν (rháptein), "to sew" or "to stitch."^[7]^[1]^[8] This Greek root was borrowed into New Latin as raphē during the 18th century, where it began appearing in scientific literature to describe linear junctions or seams in anatomical and botanical specimens.^[1]^[9] The earliest documented use of "raphe" in English scientific contexts dates to circa 1753, marking its entry into formal medical and natural history texts.^[1] In contemporary English, the term is pronounced /ˈreɪfi/ (RAY-fee), reflecting a phonetic adaptation from its classical origins, while Latin renditions in historical texts exhibited variations such as closer adherence to ecclesiastical or classical Latin phonetics.^[9]^[10]

General Definition

In biology and anatomy, a raphe refers to the seamlike union of the two lateral halves of a part or organ, often manifesting externally as a ridge or furrow.^[1] This structure represents a line of junction between symmetrical components, commonly observed in various tissues where bilateral elements meet.^[11] For instance, it denotes a fibrous or midline feature formed by the apposition of similar parts.^[12] Raphes typically arise from the fusion of bilateral structures during embryonic development, resulting in a visible or palpable line that may appear either externally on surfaces or internally within organs.^[13] This developmental process involves the closure of midline seams, leaving a remnant that marks the site of union and can extend across connected regions.^[14] Such characteristics distinguish raphes from mere surface features, emphasizing their origin in symmetrical morphogenesis. Historically, the term raphe—derived from the Greek word for "seam"—entered scientific usage around 1753 as a purely descriptive label for anatomical ridges or lines of union.^[1] Over time, with advancements in embryological research, its application has shifted toward a functional understanding, highlighting raphes as indicators of developmental fusion processes rather than isolated morphological traits.^[13] This evolution underscores the term's role in interpreting bilateral symmetry in organismal development.

Applications in Biology

In Botany

In botany, the raphe refers to a ridge of tissue extending along one side of certain ovules, linking the hilum—the attachment point to the placenta—with the chalaza at the ovule's base. This structure forms through the fusion of the funiculus with the ovule's integument during development.^[15] It is characteristic of anatropous ovules, the inverted orientation most common among angiosperms, where the micropyle faces the placenta due to 180-degree curvature.^[16] In contrast, orthotropous ovules, which remain upright without such inversion, lack a raphe.^[15] The raphe plays a key role in seed development by channeling vascular bundles from the funiculus to the chalaza, supplying nutrients and water to the embryo and endosperm. It also provides mechanical support to the elongating ovule and maturing seed.^[15] In the seed coat, or testa, the raphe persists as a subtle longitudinal ridge, aiding overall structural integrity during dispersal.^[17] This feature is particularly evident in families like Fabaceae, where the raphe appears as a prominent white line on soaked pea seeds, running from the hilum toward the micropyle opposite the embryo's attachment. It is also present in Orchidaceae, supporting the vascular needs of their tiny, wind-dispersed seeds derived from anatropous ovules.^[17]^[18] Evolutionarily, the raphe emerged as part of ovule curvature in early seed plants, with fossil records of complex, vascularized ovules resembling anatropous types documented from Carboniferous seed ferns, enhancing nutrient delivery and adaptations for seed protection and dispersal in terrestrial environments.^[19]

In Diatoms

In raphid diatoms, the raphe is defined as a longitudinal slit or canal penetrating the silica frustule, the siliceous cell wall, which facilitates the secretion of mucilage for cellular functions.^[20] This structure is characteristic of pennate diatoms within the subclass Bacillariophycidae, distinguishing them from other groups.^[21] The raphe typically consists of paired slits on the valve face, terminating at a central nodule—a thickened, silicified region between the proximal ends—and polar nodules at the distal ends, which anchor and direct the structure.^[22] These nodules provide structural reinforcement and are integral to the raphe's continuity across the valve.^[21] Raphe-bearing valves, known as raphid, contrast with araphid diatoms that lack this feature, serving as a primary morphological delimiter in diatom classification. Functionally, the raphe enables gliding motility in benthic environments by allowing directional extrusion of adhesive mucilage from the slits, propelling the cell along substrates such as sediments or biofilms while permitting reversible attachment.^[23] This mechanism relies on interactions between the extruded material and the underlying surface, facilitating navigation and positioning in aquatic habitats.^[24] In diatom taxonomy, the presence of the raphe is a defining trait that separates raphid pennates from other clades, contributing to the diversification of over 100,000 estimated diatom species worldwide.^[25] The raphe's evolution, linked to adaptations for benthic lifestyles, dates back to the Late Cretaceous (approximately 80 million years ago), with fossil records indicating origins around this time, though molecular phylogenies suggest a potentially earlier emergence in the mid-Cretaceous; this marked a key innovation that enhanced ecological versatility.^[26]^[27] Prominent examples include genera such as Navicula and Pinnularia, which feature well-developed raphe systems supporting their roles in forming and maintaining aquatic biofilms through motility and substrate colonization.^[28] These genera exemplify how the raphe underpins ecological contributions in freshwater and marine ecosystems.^[29]

Human Anatomy

Anatomical Concept

In anatomy, a raphe refers to a seam-like union of the two lateral halves of an organ or tissue, typically situated along the midline, resulting from the embryonic fusion of bilateral primordia.^[1]^[30] This structure manifests as a ridge, furrow, or line marking the site of apposition where symmetrical embryonic components converge and adhere during development.^[13] The embryological origin of raphae traces to the closure of bilateral structures in early gestation, spanning approximately weeks 4 to 12, when processes such as the fusion of neural folds (forming the neural raphe), urethral or genital folds (contributing to the perineal raphe), and palatal shelves (yielding the palatine raphe) occur.^[31]^[32]^[33] These fusions are driven by cellular migration, adhesion molecules, and programmed apoptosis, establishing a continuous midline seam that persists into postnatal life.^[34] Raphae generally serve functions of structural reinforcement, providing tensile strength to fused tissues; anatomical demarcation, such as separating functional compartments within organs; and occasionally incorporating sensory nerves or vascular elements for localized innervation or perfusion.^[3] Histologically, they consist primarily of fibrous connective tissue, stratified epithelium, or interlacing muscle fibers, often with embedded collagen bundles, and may include nerve fibers or capillaries depending on the site.^[13]^[4] In comparative anatomy, raphae appear across vertebrates, such as the median raphe on the tongue of teleost fish, where it aligns lingual folds for sensory and mechanical roles, and in various invertebrates, including a ciliated raphe in the mantle or foot of certain mollusks aiding in locomotion or secretion.^[35]^[36] However, detailed studies predominate in mammals, where these structures underpin midline integrity in diverse organs.^[37]

Major Examples

The perineal raphe is a prominent midline ridge of tissue extending from the anus through the perineum to the posterior aspect of the scrotum in males or the vulva in females, serving as a visible seam that marks the fusion line of the embryonic urogenital folds and internally separates the left and right compartments of the perineum.^[13] This fibrous structure provides structural support to the surrounding musculature, including attachments for the bulbospongiosus and superficial transverse perineal muscles, and contributes to the integrity of the pelvic floor during activities such as defecation and urination.^[37] The penile and scrotal raphe represent the anterior continuation of the perineal raphe, forming a linear ridge along the ventral midline of the penis and scrotum, respectively, which delineates the site of embryonic fusion and aids in the distribution of skin tension across these regions.^[3] In males, the penile raphe extends from the frenulum of the prepuce to the scrotal raphe, while the scrotal raphe runs along the midline of the scrotal sac, both serving as landmarks for surgical approaches in urogenital procedures.^[38] The palatine raphe is a midline fibrous ridge traversing the hard palate from the incisive papilla anteriorly to the posterior border, anchoring the oral mucosa and providing attachment for the transverse palatine folds while facilitating the stability of the palatal vault during mastication and speech.^[39] This structure, often subtly elevated, ends posteriorly near the soft palate junction and is continuous with the median fibrous septum that supports the palatal musculature.^[40] The pharyngeal raphe constitutes a posterior midline fibrous band in the pharyngeal wall, extending from the base of the skull to the cricoid cartilage, where it serves as the primary insertion and origin point for the superior, middle, and inferior pharyngeal constrictor muscles, enabling coordinated constriction during swallowing and phonation.^[41] This raphe integrates fibers from the constrictors on either side, forming a median septum that maintains pharyngeal lumen patency and structural alignment.^[42] The pterygomandibular raphe is a bilateral tendinous band of buccopharyngeal fascia stretching from the hamulus of the medial pterygoid plate superiorly to the posterior border of the mylohyoid line on the mandible inferiorly, acting as a key attachment for the buccinator muscle anteriorly and the superior pharyngeal constrictor posteriorly to support buccal and masticatory functions.^[4] Positioned in the submucosal layer of the cheek, it reinforces the retromolar trigone region and influences the dynamics of mouth opening and closure.^[43] The median raphe of the tongue appears as a subtle midline fibrous seam within the intrinsic lingual musculature, separating the left and right genioglossus and other tongue muscles while providing a scaffold for their transverse and longitudinal fibers to interdigitate, thus contributing to the tongue's flexibility in articulation and deglutition.^[44] This structure, embedded in the fibrofatty septum of the tongue body, ensures symmetrical movement and is evident on cross-sectional imaging as a central divider.^[45] The bulbospongiosus raphe refers to the median fibrous raphe along the ventral aspect of the bulbospongiosus muscle in the superficial perineal pouch, where bilateral muscle fibers converge to encircle the bulb of the penis in males or the vestibule in females, facilitating rhythmic compression for urethral emptying and ejaculatory propulsion.^[46] This raphe originates from the perineal body and extends anteriorly, blending with the penile raphe to form a continuous midline reinforcement in the urogenital region.^[47]

Raphe nuclei

The raphe nuclei are a cluster of nuclei located along the midline raphe of the brainstem, extending through the midbrain, pons, and medulla oblongata. Primarily composed of serotonergic neurons, they project to various brain regions and modulate functions including mood, sleep, appetite, and pain. The dorsal raphe nucleus is the largest of these, playing a key role in the serotonergic system.^[5]

Teratology and Developmental Anomalies

Dysraphism

Dysraphism denotes the incomplete or defective fusion along a raphe—a seam or ridge marking the union of embryonic structures—during early development, resulting in a spectrum of congenital anomalies. The term originates from the Greek prefix "dys-" (indicating bad or abnormal) combined with "rhaphē" (suture or seam), emphasizing the pathological failure in midline closure processes.^[48] This condition primarily affects midline structures, leading to defects that can involve neural, cutaneous, or other tissues, and it underscores disruptions in the precise embryogenetic fusion that normally forms the raphe.^[49] The mechanisms underlying dysraphism are multifactorial, involving genetic, metabolic, and environmental factors that impair key developmental stages such as neural tube closure around the third and fourth weeks of gestation. Disruptions in neural crest cell migration, which contributes to midline structure formation, play a central role, often compounded by defects in folate metabolism; for instance, polymorphisms in the MTHFR gene reduce the enzyme's efficiency in converting folate to its active form, elevating homocysteine levels and hindering DNA synthesis essential for cell proliferation during neurulation.^[50] Environmental influences, such as maternal exposure to valproic acid—an anticonvulsant that interferes with neural tube closure—can increase risk by up to tenfold, highlighting the interplay between teratogenic agents and underlying vulnerabilities.^[51] Overall, these processes reflect a failure in the coordinated fusion of bilateral embryonic halves, contrasting with the seamless raphe development seen in typical embryogenesis. Dysraphism is broadly classified into open and closed forms based on the presence of exposed neural elements, as well as neural versus non-neural categories depending on the affected system. Open dysraphism involves direct exposure of neural tissue to the external environment, often without adequate skin covering, as exemplified by myelomeningocele where the spinal cord and meninges protrude through a vertebral defect.^[52] In contrast, closed dysraphism features intact overlying skin that conceals underlying anomalies, such as intraspinal lipomas or dermal sinuses, potentially leading to tethered cord syndrome over time.^[53] Neural dysraphisms predominantly affect the central nervous system, while non-neural variants involve other midline fusions, including urogenital structures like the urethral raphe in conditions such as hypospadias, where incomplete closure of urethral folds results in an abnormally positioned meatus.^[54] This classification aids in prognostic assessment, with open forms generally carrying higher risks of neurological impairment due to cerebrospinal fluid leakage and infection.^[55] Globally, dysraphism and related neural tube defects occur in approximately 1 to 3 per 1,000 live births, though prevalence varies regionally and has declined with folic acid fortification programs.^[56] Rates are notably higher—up to 10-fold—in areas with inadequate maternal folate intake or nutritional deficiencies, underscoring the protective role of periconceptional folic acid supplementation in mitigating folate-sensitive mechanisms.^[51] Diagnosis of dysraphism relies on prenatal screening to enable early intervention, primarily through maternal serum alpha-fetoprotein (AFP) testing, which detects elevated levels indicative of open neural defects due to leakage into amniotic fluid.^[57] Targeted ultrasound examinations, typically performed between 18 and 22 weeks of gestation, visualize structural anomalies like vertebral arch defects or sac-like protrusions, confirming the diagnosis with high sensitivity.^[58] For cases with suspected genetic underpinnings, such as MTHFR variants or syndromic associations (e.g., Meckel-Gruber syndrome), amniocentesis or chorionic villus sampling facilitates molecular testing to identify chromosomal abnormalities or specific mutations.^[59] Postnatal imaging, including MRI, further delineates closed forms, but prenatal approaches remain crucial for counseling and planning.^[53]

Specific Malformations

Neural tube dysraphism encompasses a spectrum of malformations arising from incomplete closure along the dorsal midline raphe during embryogenesis, with spina bifida occulta representing the mildest form characterized by a vertebral arch defect without protrusion of neural elements or meninges.^[48] This condition often remains asymptomatic, though subtle signs such as a tuft of hair, dermal sinus, or subcutaneous lipoma may overlie the affected site, potentially leading to later tethered cord syndrome if untreated.^[60] In contrast, myelomeningocele is a severe open defect where the unfused neural placode and meninges herniate through the spinal defect, commonly in the lumbosacral region, resulting in risks of lower limb paralysis, bowel and bladder dysfunction, and hydrocephalus due to associated Chiari II malformation.^[48]^[61] Urogenital raphe defects involve disruptions in the midline fusion of the urethral folds, manifesting as hypospadias, where the urethral meatus opens proximally along the ventral penile raphe rather than at the glans tip, affecting approximately 1 in 250 male births and often accompanied by chordee or hooded foreskin.^[54] Epispadias presents as a dorsal urethral opening defect, typically less common than hypospadias and part of the exstrophy-epispadias complex, leading to urinary incontinence and genital malformation.^[62] Scrotal raphe agenesis is a rare anomaly involving absence of the midline scrotal seam, frequently associated with caudal dysplasia syndromes and other urogenital anomalies like penile agenesis or imperforate anus.^[63] Other raphe-related malformations include cleft palate, resulting from failure of the palatine shelves to fuse along the midline raphe, which can occur in isolation or combined with cleft lip, leading to feeding difficulties, speech impediments, and ear infections.^[64] Anorectal malformations, such as imperforate anus, arise from perineal raphe disruption due to incomplete urorectal septum development, often presenting with absent anal opening and associated fistulas, requiring immediate evaluation for bowel continuity.^[65]^[66] Treatment for these malformations primarily involves surgical repair to restore function and prevent complications; for instance, fetal surgery for myelomeningocele, pioneered in the Management of Myelomeningocele Study (MOMS) trial from the early 2010s, closes the defect in utero to mitigate hindbrain herniation and improve motor outcomes. Postnatal repairs for urogenital and anorectal defects utilize techniques like urethroplasty for hypospadias or posterior sagittal anorectoplasty for imperforate anus. Periconceptional folic acid supplementation (400 μg daily) serves as prophylaxis, reducing neural tube defect risk by up to 70%.^[67] Prognosis varies by malformation severity and intervention timing; early surgical correction in myelomeningocele enhances mobility and continence rates, with many children achieving independent ambulation, though long-term challenges like Chiari malformation-related hydrocephalus persist in up to 80% of cases without prenatal repair.^[68] For hypospadias, successful repair yields good cosmetic and functional results in over 90% of cases, while anorectal anomalies benefit from multidisciplinary care to optimize bowel control.^[69]

References

[1]
raphe | Taber's Medical Dictionary
A line or ridge in the median line of the palate. The raphe appears as a whitish line, which sometimes turns into a slight groove at its posterior end.Missing: definition anatomy
[2]
Perineal raphe: Anatomy and structure - Kenhub
Mar 7, 2024 · The perineal raphe comprises a ridge of tissue on the human body that extends from the anus to the perineum.<|control11|><|separator|>
[3]
The pterygomandibular raphe: a comprehensive review - PMC - NIH
Mar 31, 2024 · The pterygomandibular raphe (PMR) is a tendinous structure connecting the bucinator and the superior pharyngeal constrictor muscles.
[4]
Neuroanatomy, Nucleus Raphe - StatPearls - NCBI Bookshelf
The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, ...
[5]
Raphe - Etymology, Origin & Meaning
Originating from Greek rhaphē meaning "seam, suture," this anatomical term denotes the seam-like suture joining two lateral halves.
[6]
RAPHE Definition & Meaning - Merriam-Webster
The meaning of RAPHE is the seamlike union of the two lateral halves of a part or organ (such as the tongue) having externally a ridge or furrow.
[7]
raphe - Wiktionary, the free dictionary
Etymology. Borrowed from New Latin raphē, from Ancient Greek ῥᾰφή (rhăphḗ, “seam; suture”). ... Terms of Use · Desktop.English · Noun · Latin
[8]
raphe, n.² meanings, etymology and more | Oxford English Dictionary
raphe is of multiple origins. Partly a borrowing from Latin. Partly a borrowing from Greek. Etymons: Latin raphe; Greek ῥαϕή. See etymology. Nearby entries.
[9]
https://www.oed.com/dictionary/raphe_n2
[10]
RAPHE | definition in the Cambridge English Dictionary
RAPHE meaning: 1. a place or line where two halves of an organ in the body join 2. a place or line where two…. Learn more.
[11]
Terminology of Molecular Biology for Abdominal raphe - GenScript
The abdominal raphe is of clinical significance in surgical procedures and medical examinations. Surgeons may use the raphe as a reference point for ...Missing: embryological | Show results with:embryological
[12]
Perineal raphe with special reference to its extension to the anus - NIH
Jun 24, 2016 · The raphe of the human penis and scrotum is considered to develop secondarily after disappearance of the initial midline seam by fusion of the ...Missing: history | Show results with:history
[13]
Median raphe - Oxford Reference
In males it extends further up the scrotum and penis. It represents a fusion line from embryological development and may be the site of cysts and other harmless ...
[14]
Angiosperm ovules: diversity, development, evolution
Curved ovules have a raphe, a sometimes conspicuous area through which the vascular bundle runs from the funiculus to the chalaza. It is not useful to describe ...BASIC DIVERSITY OF... · EVOLUTIONARY ORIGIN OF... · DEVELOPMENT OF...
[15]
Lecture 25 - Seeds - Daniel L. Nickrent
Oct 14, 2022 · 2. Raphe. For anatropous ovules, the funiculus is adnate to the integument. Upon forming a seed, a ridge remains called the raphe.
[16]
[PDF] Seeds and Fruits - PLB Lab Websites
In this chapter we will discuss the structure and development of seeds and fruits and their adaptations for dispersal. The Seed Is a Mature Ovule. The seed ...
[17]
[PDF] 7 Seed Development and Structure - CABI Digital Library
The raphe is the zone where the funiculus is partly or entirely fused to the ovule (Werker, 1997) and sometimes appears as a raised ridge (Fahn, 1982) or ...
[18]
Evolution and patterning of the ovule in seed plants - Rudall - 2021
Jan 11, 2021 · Most inferences on the early evolution of the ovule are drawn from Late Devonian and Carboniferous seed-fern fossils that are anatomically ...
[19]
Origin and Evolution of the Canal Raphe System in Diatoms
One lineage of pennate diatoms has a slit through the siliceous cell wall, called a “raphe,” that functions in motility. Raphid pennate diatoms number in ...
[20]
Raphe | Glossary - Diatoms of North America
A raphe is an opening, or slit, in the silica cell wall of raphid diatoms. The raphe system includes the slit and the mucilaginous material that is secreted ...<|control11|><|separator|>
[21]
Central nodule | Glossary - Diatoms of North America
A central nodule is the thickly silicified area located between the proximal raphe ends in raphid diatoms. It is often thickened in both valve and girdle views.
[22]
Gliding motility of the diatom Craspedostauros australis coincides ...
Sep 23, 2024 · The raphe is an evolutionary adaption that allows diatoms to colonize and move on submerged surfaces, such as rocks, sand, animals, and other ...
[23]
Functional morphology of gliding motility in benthic diatoms - PNAS
Within diatoms, evolution of the raphe and gliding motility was highly consequential for species diversification (43). Although the raphe places fundamental ...
[24]
Diatom Biodiversity and Speciation Revealed by Comparative ...
Diatoms (Bacillariophyta) constitute one of the most diverse and ecologically significant groups of phytoplankton, comprising 100,000–200,000 species in three ...Missing: raphid | Show results with:raphid
[25]
Pinnularia | Genera - Diatoms of North America
Displaying 65 of 65 species ; Pinnularia marchica Length: 11-20 Width: 4-5 ; Pinnularia lagerstedtii Length: 11-26 Width: 5-6 ; Pinnularia pluvianiformis Length: ...Missing: Navicula | Show results with:Navicula
[26]
Pinnularia - an overview | ScienceDirect Topics
The pennate diatom has a slit, called a raphe, between the valves. The raphe exudes cytoplasmically produced slime in which the diatom glides. The centric ...
[27]
Raphe (anatomy) - Primary Care Notebook
Jan 1, 2018 · A raphe is a seam in tissue or organ between two separate parts, often forming fused ends of two flat muscle sheets.<|control11|><|separator|>
[28]
Embryology, Sexual Development - StatPearls - NCBI Bookshelf - NIH
Aug 28, 2023 · Later in development, the fusion site is demarcated by the scrotal raphe. A solid epithelial, or urethral, plate forms on the ventral surface ...
[29]
Raphe of the posterior neural tube in the chick embryo - PubMed
The raphe was subsequently studied in detail. It appeared very irregular, with small zones of apposed, open and fused neural folds. During closure, these raphe ...
[30]
Anococcygeal Raphe Revisited: A Histological Study Using Mid ...
The concept of the anococcygeal raphe needs to be re-examined from the perspective of fetal development, as well as in terms of adult morphology.
[31]
Morphological characteristics of the blackspot seabream (Pagellus ...
These folds were apparent on both sides of the tongue. They showed a latero‐medial orientation and aboral inclination that converged on a median raphe (Figure ...
[32]
than just slimy slugs. Shell reduction and its implications on defence ...
Note the ciliated raphe (arrow). C Clione limacina (Phipps, 1774) (Pteropoda, Gymnosomata), large single cellular glands (arrows). D Haminoea antillarum (d ...
[33]
Anatomy, Abdomen and Pelvis, Perineal Body - StatPearls - NCBI
Dec 11, 2024 · The muscular bundles originate from this raphe and the perineal body, continuing contralaterally to integrate with the transverse muscle and ...<|control11|><|separator|>
[34]
Raphe of penis - e-Anatomy - IMAIOS
The raphe of penis is the continuation of the raphe of the scrotum, forming a seam on the skin of the underside of the penis.
[35]
Palatine raphe - e-Anatomy - IMAIOS
Along the middle line of the hard palate is a linear raphæ, the palatine raphe, which ends anteriorly in a small papilla corresponding with the incisive canal.
[36]
Mouth Anatomy - Medscape Reference
Dec 9, 2024 · The secondary palate presents a midline elevated suture line termed the median or palatine raphe. The hard palate also has transverse ridges ...
[37]
Anatomy, Head and Neck: Pharyngeal Muscles - StatPearls - NCBI
Understanding pharyngeal anatomy ... The middle constrictor also inserts onto the median pharyngeal raphe, blending with superior and inferior constrictor fibers.
[38]
Pharyngeal raphe - e-Anatomy - IMAIOS
The Pharyngeal raphe is a raphe that serves as the origin and insertion for several of the pharyngeal constrictors.
[39]
Pterygomandibular raphe: Anatomy, structure and function - Kenhub
Mar 20, 2024 · Definition, The pterygomandibular raphe is a tendinous band extending from the medial pterygoid plate to the mandible. Learn more about the ...Missing: embryological | Show results with:embryological
[40]
Anatomy, Head and Neck, Tongue - StatPearls - NCBI Bookshelf
Aug 21, 2023 · The epiglottis and epiglottic region of the tongue develop from the third median swelling, which arises from the posterior fourth pharyngeal ...
[41]
Development and growth of median structures in the human tongue ...
Mar 20, 2023 · Other than in the tongue, a midline raphe or septum is also known to be present in the mylohyoideus, constrictor pharynges, and bulbospongiosus ...
[42]
Bulbospongiosus muscle - e-Anatomy - IMAIOS
Origin: Median raphé. Artery: Perineal artery. Nerve: Pudendal nerve. Action: In males, empties the urethra; in females, clenches the vagina. Description:
[43]
Bulbospongiosus Muscle | Complete Anatomy - Elsevier
In males, the bulbospongiosus muscle originates from the perineal body and a median raphe found along the ventral aspect of the penis. Insertion. In females ...
[44]
Spinal dysraphisms: highlighting discrepancies in the current ... - NIH
The basis of the word 'dysraphism' is 'raphe' which in biology strictly is 'a groove, ridge or seam in an organ or tissue, typically marking the line where ...
[45]
Neuroscience Glossary | Neurology | Washington University in St ...
dysraphism defective closure of a raphe, particularly the neural tube. dyssomnia disorder in which the main complaint is about inadequate or unrefreshing sleep ...
[46]
Spina Bifida: A Review of the Genetics, Pathophysiology and ...
Jun 6, 2022 · Christensen et al. found that MTHFR polymorphism and low folate status combined is associated with a greater risk for NTDs than either variable ...
[47]
Neural tube defects – recent advances, unsolved questions and ...
Of particular clinical significance is valproic acid (VPA), an anticonvulsant that increases risk of spinal NTDs by approximately 10-fold when taken during ...
[48]
Spinal Dysraphisms: A New Anatomical–Clinicoradiological ...
Myelomeningocele and Myelocele: These are classified under open dysraphisms. The most common type of open spinal dysraphism is myelomeningocele ( Fig. 9 ). The ...
[49]
Imaging spectrum of spinal dysraphism on magnetic resonance
On the basis of presence or absence of overlying skin covering, spinal dysraphism is divided into open and closed types[10-12] (Table 1). In OSD overlying skin ...
[50]
Hypospadias - StatPearls - NCBI Bookshelf - NIH
It is characterized by abnormal development of the urethral fold and the ventral foreskin of the penis that causes abnormal positioning of the urethral opening.
[51]
4.2e Spina Bifida (Q05.0–Q05.9) - CDC Archive
Nov 25, 2020 · Open (not skin covered but often membrane covered) versus closed (skin covered) spina bifida – important for neurological disability. Lesion ...
[52]
Spinal dysraphism - PMC - PubMed Central - NIH
Spinal dysraphism involves a spectrum of congenital anomalies resulting in a defective neural arch through which meninges or neural elements are herniated.Missing: non- | Show results with:non-
[53]
Prenatal screening for neural tube defects: from maternal serum ...
During pregnancy, women should be offered screening tests to confirm fetal chromosomal abnormalities such as Down syndrome and fetal neural tube defects (NTDs).
[54]
Prenatal diagnosis and assessment of congenital spinal anomalies
Prenatal findings: Myelomeningocele is often first suspected when routine screening during pregnancy reveals elevated levels of maternal serum alpha-fetoprotein ...
[55]
Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in ...
Objective: Midtrimester maternal serum alpha-fetoprotein (MSAFP) and sonographic evaluation have been used to screen for spina bifida.Missing: ultrasound genetic testing
[56]
Spina Bifida - StatPearls - NCBI Bookshelf
Spina bifida aperta, also known as open spinal dysraphism, refers to a defect in which neural tissue is exposed and communicates with the external environment, ...Missing: mechanisms | Show results with:mechanisms
[57]
Spinal Dysraphism (Neural Tube Defect) and Myelomeningocele ...
Jan 6, 2022 · Spinal dysraphism consists of congenital malformations caused by maldevelopment of ectodermal, mesodermal, and neuroectodermal tissues and ...Magnetic Resonance Imaging · Ultrasonography · Anterior Sacral MeningoceleMissing: raphe | Show results with:raphe<|control11|><|separator|>
[58]
Epispadias - StatPearls - NCBI Bookshelf - NIH
Apr 21, 2024 · Epispadias is a rare congenital anomaly in which the urethra opens onto the dorsal aspect of the penis in boys and is often displaced anteriorly in girls.Missing: raphe | Show results with:raphe
[59]
Agenesis of the penis, scrotal raphe, and anus in one of ... - PubMed
They result from damage to multiple germ layers at a very early stage of development and vary in severity depending on the timing and degree of insult incurred.Missing: dysplasia | Show results with:dysplasia
[60]
Development of Normal and Cleft Palate: A Central Role for ...
Jul 19, 2018 · Cleft palate results from failed midline fusion of the paired palatine shelves. Embryologic errors of formation leading to cleft palate ...
[61]
Anorectal malformations - PMC - PubMed Central - NIH
Perineal fistulas in both male and female have traditionally been called "low" defects. In these cases the rectum opens in a small orifice, usually stenotic and ...
[62]
https://www.ncbi.nlm.nih.gov/books/NBK563180/
[63]
Folic Acid Supplementation to Prevent Neural Tube Defects ... - NCBI
High levels of folic acid supplementation (4 mg) have been found to reduce the risk of recurrent NTDs by more than 70 percent, and even more modest levels of ...
[64]
Fetal Surgery for Spina Bifida: Past, Present, Future - PMC
Fetal surgery for MMC before 26 weeks' gestation may preserve neurologic function, reverse the hindbrain herniation of the Chiari II malformation.
[65]
Hypospadias: Practice Essentials, Pathophysiology, Etiology
Oct 4, 2023 · Hypospadias is an abnormality of anterior urethral and penile development. The urethral opening is ectopically located on the ventral aspect of the penis.