Murraya is a genus of flowering plants in the family Rutaceae, comprising over 17 species of evergreen shrubs and trees native to tropical and subtropical regions of Asia, Australia, and the Pacific Islands.[1]The genus is characterized by unarmed trees or shrubs with odd-pinnate leaves featuring more than seven alternate leaflets that often emit a spicy or peppery scent when crushed, large axillary or terminal panicle inflorescences, 5-merous flowers with 10 free stamens, and small ovoid or subglobose berries containing mucilaginous pulp.[2] Named after the 18th-century Swedishbotanist Anders Murray, the taxonomy of Murraya remains somewhat fluid, with narrower circumscriptions recognizing as few as 8 species while broader ones include up to 17, some of which have been reclassified into related genera like Bergera.[3][4]Prominent species include Bergera koenigii (commonly known as the curry leaf tree; formerly Murraya koenigii), a small tree up to 6 meters tall native to tropical Asia, including the Indian subcontinent, southern China, and Southeast Asia, and valued in South Asian cuisine for its aromatic pinnate leaves used as a seasoning, as well as in traditional Ayurvedic medicine for treating ailments like fever, dysentery, and diabetes.[5][6][7] Another key species, Murraya paniculata (orange jessamine), is a compact shrub or small tree growing 2.5–6 meters high with glossy green compound leaves and clusters of fragrant white flowers, widely cultivated as an ornamental hedge plant in tropical gardens and noted for its use in traditional remedies against abdominal pain and inflammation.[8][9]Species of Murraya are employed in landscaping for their dense crowns and attractive blooms, as rootstocks for citrus grafting due to their vigor and disease resistance, and in ethnomedicine for their rich phytochemical profile, which includes over 400 isolated compounds such as alkaloids (e.g., mahanine), coumarins, and flavonoids exhibiting antioxidant, antimicrobial, antidiabetic, and anti-inflammatory activities.[2][1] While generally non-invasive in native ranges, some like M. paniculata can become weedy in introduced areas such as Florida.[10]
Taxonomy
Etymology and History
The genus Murraya was established by Carl Linnaeus in 1771 in his work Mantissa Plantarum Altera, honoring Johan Andreas Murray (1740–1791), a Swedishbotanist, physician, and one of Linnaeus's students who later became a professor of botany at the University of Göttingen.[11][12] The name derives from Murray's surname, following the botanical convention of eponymy to commemorate significant contributors to the field. Linnaeus's description was based on an unpublished account by Johann Gerhard König, a German botanist working in India, who provided early observations of the plants.[12]Early taxonomic work on Murraya in the 18th and 19th centuries focused on incorporating related species into the genus within the Rutaceae family. In 1825, Kurt Sprengel transferred Bergera koenigii (now often recognized separately) into Murraya, expanding its scope based on morphological similarities.[12] By the early 20th century, Japanese botanist Tyôzaburô Tanaka subdivided the genus into two sections in 1929—Murraya and Bergera—accommodating a broader circumscription that included approximately 17 species distributed across tropical and subtropical regions.[12][1]Taxonomic revisions in the 21st century, driven by molecular phylogenetics, have significantly refined the genus's boundaries. A 2021 study by Feng-Juan Mou and colleagues, integrating DNA sequence data (from nuclear and plastid regions) with morphological analysis, narrowed Murraya sensu stricto to eight accepted species, excluding others previously included.[12] This revision reclassified several taxa, such as Murraya alternans to the genus Bergera, and recognized closer affinities of section Murraya with Merrillia in the tribe Citreae, leading to transfers like Murraya zollingeri (formerly in a broader sense).[12] These changes addressed the polyphyletic nature of the earlier broad circumscription, emphasizing monophyly for more accurate classification.[12]
Classification
Murraya belongs to the kingdom Plantae, within the clade Angiosperms, superclade Eudicots, and clade Rosids. It is placed in the order Sapindales, family Rutaceae, subfamily Aurantioideae, and tribe Citreae.[13] This placement reflects recent molecular phylogenetic analyses that reposition the genus from earlier assignments in tribe Clauseneae to Citreae, based on shared synapomorphies such as oil glands and fruit structures typical of the citrus-related lineages.[13]Phylogenetically, Murraya forms a monophyletic group closely allied with the genus Merrillia within tribe Citreae, supported by analyses of nuclear ribosomal ITS and multiple chloroplast regions including trnL-F, atpB-rbcL, matK, psbH-petB, and psbA-trnH.[14] This clade is distinct from the core Citrus lineage (including Citrus, Fortunella, and Poncirus), which occupies a separate position in Citreae, as evidenced by Bayesian inference and maximum likelihood trees showing Murraya-Merrillia as a basal sister group to the expanded Citrusclade.[15] In contrast, the former Murraya section Bergera, now recognized as the separate genus Bergera, is phylogenetically distant, forming a monophyletic sister group to Clausena in tribe Clauseneae, confirmed by the same molecular markers that highlight differences in carbazolealkaloid profiles and floral morphology.[14]Recent taxonomic revisions have narrowed the circumscription of Murraya to eight species, excluding those previously in section Bergera, which were reclassified into Bergera based on integrative evidence from morphology, chemotaxonomy, and molecular phylogenetics. The 2021 revision by Mou et al. established Murraya s.s. as comprising species like M. paniculata and M. koenigii (now in Bergera), with Bergera encompassing 11 species transferred via new combinations such as Bergera koenigii and B. siamensis, justified by non-monophyly of the broad Murraya sensu lato and distinct evolutionary lineages.[14] These changes resolve long-standing polyphyly issues identified in earlier studies using cpDNA and ITS data.[15]
Accepted Species
The genus Murraya sensu stricto, as revised in 2021, comprises eight accepted species, distinguished primarily by morphological characters such as leaflet shape, fruit morphology, and inflorescence structure.[12]
Murraya alata Drake: A shrub reaching 1–3 m tall, notable for its winged rachises and vermilion berries containing 1–2 seeds.[12]
Murraya intermedia (M.Roem.) Mabb.: Features slender branches and pale-yellow, lanceolate leaflets, producing ellipsoid fruits 1.5–2 cm long.[12]
Murraya glenieii Thwaites ex Oliv.: An endemic shrub to Sri Lanka with a 4–5-lobed ovary, yielding distinctive orange, star-shaped fruits.[12]
Murraya lucida (G.Forst.) Mabb.: A 2–3 m shrub with hirsute twigs and oil-dotted leaflets, bearing red globose berries.[12]
Murraya omphalocarpa Hayata: Characterized by broad leaflets and rostrate berries, distributed in Taiwan and the Philippines.[12]
Murraya paniculata (L.) Jack: A tree up to 8 m tall with obovate leaflets, known for its orange to vermilion berries.[12]
Murraya sumatrana Roxb.: A large shrub native to Sumatra, featuring ovate leaflets and white flowers.[12]
Murraya zollingeri (Tanaka) F.J.Mou: A shrub with declined rachis, producing globose, hairy fruits in Timor and the Philippines.[12]
Following the 2021 revision, several species formerly placed in Murraya section Bergera were recognized as distinct and transferred to the reinstated genusBergera J.Koenig ex L. in a 2023 taxonomic study, including Bergera koenigii (L.) F.J.Mou (previously Murraya koenigii L., noted for its aromatic leaves) and Bergera alternifolia (Kurz) F.J.Mou (previously Murraya alternans (Wall. ex M.Roem.) Swingle), among 11 total species in Bergera; this separation was anticipated but not formally published as of 2021.[16][12]This taxonomic consensus is supported by Plants of the World Online, which aligns with the eight accepted species in Murraya sensu stricto while listing transferred taxa under Bergera.[4]
Description and Morphology
Habit and Growth
Murraya species are typically evergreen shrubs or small trees, exhibiting a compact to spreading growth form with dense branching that contributes to their suitability for hedging and ornamental landscaping. The plants generally reach heights of 2 to 7 meters, though some species like Murraya paniculata can attain up to 12 meters under optimal conditions, while others such as Murraya koenigii are more modest at 4 to 6 meters.[17][18] Their branching structure is fine-textured and often pubescent in the first year, developing a mottled appearance in subsequent years, with unarmed twigs that lack persistent thorns or prickles.[2]Growth patterns in the genus are characterized by moderate to slow rates, with plants responding well to pruning, which encourages denser foliage and maintains shape in cultivated settings. For instance, M. paniculata tolerates trimming to as low as 60–90 cm for low hedges, while M. koenigii can sucker freely from the base, potentially forming thickets if not managed.[17][18] Environmental adaptations include notable drought tolerance once established, allowing survival in periods of water stress across tropical and subtropical ranges; M. koenigii thrives in rainfall regimes of 500–2,500 mm and temperatures from 8–47°C, up to elevations of 1,600 meters.[18] Similarly, M. paniculata prefers well-drained loams but endures occasional light frost down to -4°C and elevations to 1,300 meters.[17]A distinctive feature of Murraya foliage is its aromatic quality, stemming from glandular structures that secrete essential oils, imparting scents ranging from spicy and peppery to curry-like pungency when crushed. These oils, present in concentrations up to 0.01% in species like M. paniculata (containing cadinene and sesquiterpenes), are unique to the genus and contribute to its ecological and horticultural value.[2][17][18]
Leaves and Flowers
The leaves of Murraya species are typically alternate and odd-pinnate, consisting of 3 to 13 alternate leaflets arranged along an unwinged rachis, with the leaflets often glabrous, leathery to membranous, and glossy in appearance.[19][20] These leaves are usually glandular and emit a strong aromatic scent, which varies by species; for instance, in M. koenigii, the leaflets produce a distinctive curry-like fragrance due to volatile compounds.[21][22] This aromatic quality aids in plant identification and contributes to the ecological interactions of the genus.The flowers of Murraya are bisexual and fragrant, typically white or cream-colored, and arranged in terminal or axillary inflorescences that form panicles, thyrses, cymes, or racemes.[19][20] Each flower is 4- or 5-merous, featuring sepals that are ovate to lanceolate and connate at the base, petals that are imbricate in bud and narrowly elliptic to oblanceolate (up to 2 cm long), and (5-)8 to 10 stamens with linear filaments of unequal lengths.[19][23] The fragrance, often sweet and citrus-like, plays a key role in attracting pollinators.Pollination in Murraya is primarily entomophilous, with flowers providing nectar and pollen resources that draw in insects, particularly hymenopterans such as bees, which dominate visitation (up to 97.5% of observed interactions), alongside occasional lepidopterans like butterflies.[24][25] The strong floral scent enhances this attraction, facilitating cross-pollination in these shrubs and small trees.[26]
Fruits and Seeds
The fruits of Murraya species are typically fleshy berries that develop from the small, white flowers, measuring 0.5–2.0 cm in length and 0.6–1.2 cm in diameter, with shapes ranging from ovoid to subglobose or ellipsoid across the genus.[12] These berries feature mucilaginous pulp and a fleshy endocarp, ripening to vibrant colors such as orange, red, vermilion, or black depending on the species; for example, M. paniculata produces broadly ovoid berries that turn red to purplish-black, while M. koenigii yields small, shiny black berries.[12][3]Each fruit generally contains 1–2 seeds, though some species like M. glenieii may have up to 3; the seeds are medium-sized, with a hard, often villous (hairy) testa and plano-convex cotyledons containing oil glands.[12] In M. paniculata, seeds are villous with gray-white hairs, contributing to their protected structure.[12]Seed dispersal in Murraya is primarily ornithochorous, facilitated by frugivorous birds attracted to the colorful, fleshy fruits, which enables long-distance spread; secondary dispersal by ants or through human activities like garden waste dumping also occurs but is less dominant.[27][3]Germination rates vary by species and environmental conditions, often exhibiting dormancy; for M. paniculata, rates reach 20–30% under optimal sowing in spring, with a minimum period of 36 days and epigeal emergence, while earlier sowings show prolonged dormancy until warmer months.[28] In M. koenigii, seeds germinate freely under partial shade at temperatures above 20°C (68°F), though the process can be erratic and take over a month.[29]
Distribution and Ecology
Geographic Range
The genus Murraya is native to tropical and subtropical regions of Asia, with its center of diversity located in southern China and Southeast Asia, particularly in areas such as the Indo-China Peninsula, Malay Peninsula, and Indonesian Archipelago.[4][12] This distribution extends eastward to New Guinea, New Caledonia, and the southwestern Pacific Islands, including Vanuatu, the Solomon Islands, and Fiji, as well as southward to northeastern Australia, encompassing Queensland, New South Wales, and the Northern Territory.[4] Specific native locales include the Andaman and Nicobar Islands, Sri Lanka, Taiwan, and the Philippines, reflecting a broad span across over 40 distinct regions in Asia and the Pacific.[4][12]Several species exhibit more restricted native distributions within this range. For instance, Murraya koenigii (often classified under Bergera koenigii in recent taxonomy) is primarily native to the Indian Subcontinent, including India, Sri Lanka, Bangladesh, and parts of southern China and the Malay Peninsula.[7]Murraya paniculata, one of the most widespread species, occurs natively from tropical and subtropical Asia—spanning India, southern China, and Southeast Asia—to northern Australia and Vanuatu.[30] Other species, such as Murraya glenieii, are endemic to Sri Lanka, while Murraya omphalocarpa is confined to Taiwan and the northern Philippines.[31][32][12]Beyond its native range, Murraya species have been widely introduced and cultivated in tropical and subtropical areas globally due to their ornamental and utilitarian value. Introduced populations are established in regions such as Florida and Hawaii in the United States, the Caribbean (including Cuba, Puerto Rico, and the Cayman Islands), and parts of Central and South America like Mexico, Colombia, Ecuador, and Venezuela.[4] Additional introductions occur in the Indian Ocean islands (e.g., Mauritius, Réunion, Seychelles, Comoros) and the Pacific (e.g., Caroline Islands, Marianas, Marshall Islands), where some species have naturalized.[4] In India, while several species are native, M. paniculata and others are extensively cultivated beyond their natural limits.[12]
Habitat Preferences
Murraya species predominantly inhabit tropical and subtropical biomes, favoring environments such as moist evergreen and deciduous forests, vine thickets, scrublands, and coastal areas near beaches. For instance, Murraya koenigii thrives in the understory of moist forests across South Asia, while M. paniculata commonly occurs as a shrub in vine thickets and open woodlands behind coastal dunes. These habitats provide the dappled light and humidity essential for their growth, with the genus showing a preference for elevations from sea level up to approximately 1500 meters in montane forests.[33][34]The plants require warm, humid climates characterized by temperatures between 26–37°C and moderate annual rainfall of 1000–2000 mm, often associated with monsoonal patterns in tropical to subtropical zones. Soil conditions are critical, with a strong preference for well-drained sandy loams, red sandy soils, or limestone-based substrates that prevent waterlogging while retaining moisture; optimal pH ranges from slightly acidic to neutral (6.0–7.5). These preferences enable establishment in diverse settings, from forest edges to disturbed scrub, but the plants perform best in sheltered sites protected from strong winds.[35][3][36]Adaptations to these environments include tolerance to partial shade, allowing understory persistence in dense forests, and moderate salinity resistance in coastal species like M. paniculata, which can withstand salt spray and mildly saline soils near shorelines. Once established, many species exhibit drought tolerance, surviving brief dry periods through deep root systems, though prolonged aridity stresses growth.[37][38][34]Habitat loss poses a significant threat to Murraya populations in their native ranges, particularly through deforestation driven by agriculture, urbanization, and logging in Southeast and South Asia. For M. paniculata, ongoing forest clearance has reduced available vine thicket and coastal habitats, exacerbating vulnerability in regions like Indonesia and the Philippines. Similarly, M. koenigii faces pressure from expanding cultivation and habitat fragmentation in Indian subcontinent forests, contributing to localized declines.[39][3][40]
Ecological Role
Murraya species play a significant role in supporting biodiversity within their native and introduced ecosystems, primarily through their interactions with pollinators and frugivores. The fragrant white flowers of Murraya koenigii and M. paniculata attract a diverse array of insect pollinators, with hymenopterans such as bees dominating visitation (up to 97.5% of observed visits), followed by lepidopterans like butterflies.[25][41] These pollinators facilitate cross-pollination, enhancing genetic diversity in Murraya populations and contributing to the broader pollination networks in tropical and subtropical habitats. Additionally, the small, berry-like fruits serve as a food source for birds, which consume them and aid in seed dispersal, thereby promoting plant recruitment and supporting avian nutrition.[42][43][35]In introduced regions, certain Murraya species exhibit invasive tendencies that can alter local ecosystems. M. paniculata, for instance, has established self-sustaining populations in the Pacific Islands and in Florida (USA), where it is considered potentially invasive and listed as Category II by the Florida Invasive Plant Council, spreading via bird-dispersed seeds and competing with native vegetation in disturbed areas.[44][3] Similarly, M. koenigii is regarded as a weed in parts of Australia, rapidly colonizing natural environments through prolific fruit production and avian dispersal, potentially reducing biodiversity by outcompeting indigenous flora.[43] This invasiveness underscores the dual ecological impact of Murraya, benefiting some wildlife while posing challenges to ecosystem balance in non-native ranges.[45]Murraya plants form symbiotic associations with arbuscular mycorrhizal (AM) fungi, which enhance nutrient uptake, particularly phosphorus, in nutrient-poor soils. In M. koenigii, dominant AM species such as Glomus mosseae and Acaulospora laevis colonize roots, improving plant growth and essential oil production while fostering mutual benefits in the symbiosis.[46] For M. paniculata, the rhizosphere hosts unique AM fungi like Acaulospora soloidea, which integrate into root systems to facilitate mineral absorption and soil stability.[47] These relationships highlight Murraya's contribution to mycorrhizal networks, aiding ecosystemresilience through improved plant-fungal interactions.[48]
Uses and Cultivation
Ornamental and Horticultural Uses
Murraya paniculata, commonly known as orange jessamine, is widely valued in ornamental horticulture for its dense, glossy evergreen foliage and clusters of fragrant white flowers that bloom year-round in suitable climates.[8] These attributes make it an excellent choice for creating lush, tropical aesthetics in gardens, where it serves as a hedge, screen, or specimen plant.[37] The plant's fine-textured growth, reaching 8-12 feet in height and spread, allows for versatile landscaping applications, including borders and small tree forms in patios or street plantings.[8]In formal gardens, M. paniculata can be sheared to achieve a boxwood-like effect, suitable for topiaries or structured hedges when planted 3-4 feet apart.[8] Its compact crown and attractive red berries further enhance its appeal as a foundation plant or container specimen, particularly in well-drained soils under full sun or light shade.[49] This adaptability supports its use in both ground planting for privacy screens and potted displays on patios, provided moderate moisture is maintained.[37]The species enjoys popularity in tropical and subtropical landscaping, notably in Florida where it thrives in USDA zones 9B-11 as a tall informal screen or hedge, contributing to year-round greenery in residential and public spaces.[8] Similarly, in Australia, M. paniculata is commonly cultivated in warmer regions for hedging and garden ornamentation, valued for its evergreen structure and floral fragrance that attracts pollinators.[3]
Medicinal and Culinary Applications
Murraya species, particularly M. koenigii, have been employed in traditional medicine for various therapeutic purposes. The leaves of M. koenigii are used in Ayurvedic practices to alleviate chronic fever, often prepared as a decoction for their bitter taste that aids in reducing body temperature.[50] Additionally, extracts from the leaves exhibit pain-relieving properties.[51] Leaves of M. koenigii are utilized in folk remedies to treat dysentery, typically administered raw or boiled to manage gastrointestinal inflammation.[50]In culinary contexts, the aromatic leaves of M. koenigii, commonly referred to as curry leaves, play a central role in Indian and South Asian cooking. They are added fresh or dried to temper oils, enhancing the flavor of curries, dals, and vegetable dishes with their distinctive citrusy and nutty notes.[5] Essential oils extracted from Murraya leaves and flowers are also incorporated into food flavorings, providing natural aromatic compounds for beverages and confections.[52]Beyond medicine and food, Murraya bark finds application in cultural cosmetics. In Myanmar, the bark of M. paniculata is ground into thanaka paste, a traditional preparation applied to the face and arms for its cooling effect, skin-soothing benefits, and natural sun protection against UV radiation.[53]
Murraya species, such as M. koenigii and M. paniculata, are primarily propagated through seeds, stem cuttings, suckers, or layering, with optimal timing during warm seasons to ensure successful establishment.[54][55] For seed propagation, husks should be removed from M. koenigii seeds prior to sowing in well-drained potting mix, as this improves germination, though establishment may take 1-2 years; M. paniculata seeds require overnight soaking and warm temperatures around 82°F (28°C) for germination in 30-40 days.[54][55]Stem cuttings, typically 4 inches long taken in spring or early summer, are effective for M. paniculata when treated with rooting hormone and placed in moist potting mix under bright indirect light, while suckers from mature M. koenigii trees provide a quicker vegetative method.[55][54]Layering and grafting, such as wedge grafting on wild-type rootstock for M. koenigii, can achieve up to 66% success rates but are less common commercially due to variable outcomes with other rootstocks like wood apple (14% success).[56]Cultivation of Murraya requires full sun to partial shade, with morning sun and afternoon dappled light ideal for M. paniculata to prevent leaf scorch, and well-drained, loamy soil with a pH of 6.6-7.5 enriched with organic matter.[55][8] Watering should provide about 1 inch per week to keep soil moist but not waterlogged, allowing the top layer to dry between applications to avoid root issues, while humidity above 50% supports growth in warmer conditions above 65°F (18°C).[55][54] Fertilization with nitrogen-rich or balanced evergreen formulas every 3-5 weeks during spring and summer promotes vigorous foliage and flowering, and plants in containers need repotting every few years into larger pots without root disturbance.[55][54] Pest management involves monitoring for aphids, scale, whiteflies, and nematodes, treated with neem or horticultural oils and encouraging natural predators like ladybugs.[55]Challenges in non-tropical climates include high sensitivity to frost, with most species tolerating only occasional light freezes down to about 28–32°F (-2 to 0°C) before requiring indoor overwintering or protection via mulch and covers.[37][55] Overwatering leads to root rot and yellowing leaves, particularly in poorly drained soils, while excessive direct summer sun can cause sunburn on foliage.[54][55] In cooler regions, maintaining stable warmth and humidity is essential, as air layering often fails and seeds are recalcitrant, limiting rapid propagation.[56]
Chemistry and Pharmacology
Major Chemical Constituents
Murraya species, particularly M. koenigii and M. paniculata, contain a variety of bioactive secondary metabolites, with coumarins, alkaloids, and essential oils representing the major chemical classes. These compounds are primarily isolated from leaves, bark, stems, and fruits through solvent extraction followed by chromatographic techniques such as column chromatography and high-performance liquid chromatography (HPLC). Structural elucidation is typically achieved via spectroscopic methods including nuclear magnetic resonance (NMR) and mass spectrometry (MS), revealing characteristic fused ring systems in coumarins and indole-based scaffolds in alkaloids.[57]Coumarins form a prominent group in the leaves and bark of Murraya species, contributing to their structural diversity with over 120 variants reported. Murrangatin, a simple coumarin derivative featuring a prenylated benzene ring fused to a pyrone moiety, has been isolated from the leaves and stems of M. paniculata, M. koenigii, and related species like M. alata and M. omphalocarpa. Umbelliferone, a 7-hydroxycoumarin with a hydroxyl group at the 7-position, is found in the bark and roots of M. paniculata, often co-occurring with angular furocoumarins that exhibit extended aromatic systems. These isolations highlight the plant's biosynthetic capacity for oxygen-heterocyclic compounds, concentrated in aerial parts.[57][58]Alkaloids, numbering around 193 across the genus, are predominantly carbazoles and bisindoles, extracted mainly from leaves and fruits using ethanol or chloroform solvents. Girinimbine, a carbazolealkaloid with a tricyclicindole-fused structure and a methyl substituent, is isolated from the leaves of M. koenigii and M. euchrestifolia. Similarly, mahanimbine, featuring an additional geranyl side chain on the carbazole core, occurs in the leaves of M. koenigii and M. euchrestifolia. The bisindole alkaloid yuehchukene, characterized by two linked indole units forming a dimeric structure, has been obtained from the roots and fruits of M. paniculata, underscoring species-specific distribution in reproductive and underground tissues.[60]Essential oils, volatile terpenoids responsible for the characteristic aroma, are steam-distilled from leaves and constitute 0.05–1.0% of dry weight in M. koenigii. These oils exhibit chemotypic variation, with major components including α-pinene (up to 65.7%), β-phellandrene (up to 50.1%), and β-caryophyllene (up to 53.9%) depending on geography and accession.[61][62]
Biological Activities
Compounds isolated from Murraya species, particularly carbazole alkaloids such as murrayanine and mahanine, have demonstrated notable anti-inflammatory effects by inhibiting nitric oxide production in microglial cells, with murrayanine showing an IC₅₀ value of 12.2 ± 0.2 µM in BV-2 cells.[57] These carbazoles, including koenimbine, also exhibit analgesic properties, reducing pain and inflammation in experimental models, as confirmed by phytochemical and pharmacological analyses of M. koenigii extracts.[63]Yuehchukene, a bis-indole alkaloid from M. paniculata, displays potential anti-cancer activity, particularly against breast cancer cells in vitro, where it inhibits proliferation and attenuates estrogenic actions when combined with cyclophosphamide, suggesting utility in chemo-hormonal therapy.[64] Additionally, carbazoles like mahanine from M. koenigii exhibit cytotoxicity against various cancer cell lines, including HeLa, HT-29, HL-60, and MCF-7breast cancer cells, with studies in mouse models demonstrating reduced tumor growth.Coumarins from Murraya species, such as those isolated from M. paniculata and M. exotica, possess antifungal and antibacterial properties; for instance, murratin D inhibits microbial growth with an IC₅₀ of 39.0 ± 4.3 µM, while extracts show activity against Staphylococcus aureus, Escherichia coli, Candida spp., and Aspergillus spp., comparable to standard antibiotics like amikacin.[57][65][63]Extracts of M. koenigii have been reported to exhibit estrogenic effects in animal models, enhancing ovarian folliculogenesis and inducing puberty in immature rats, potentially due to phytoestrogens such as genistein.[66] Yuehchukene also shows weak estrogenic activity, binding to estrogen receptors with a relative affinity of 1/150 to 1/300 compared to estradiol, alongside mixed anti-estrogenic effects.[67]Toxicity concerns in Murraya species include potential phototoxicity from furocoumarins like psoralens present in some taxa, which can cause skin sensitization upon UVA exposure, though essential oils are generally considered safe for internal use with caution; further studies on dose-dependent effects are recommended.[57]
Cultural and Historical Significance
Traditional Uses in Culture
In Indian cultural traditions, Murraya koenigii, known as the curry leaf tree, is revered for its spiritual and protective qualities. Referred to as Krishnanimba or Girinimba in Ayurvedic texts, the plant derives its name from Lord Krishna, the Hindu deity embodying protection, underscoring its role as a safeguard against misfortune in ancient scriptures.[50] Its leaves are incorporated into Hindu pujas and household rituals, where they symbolize purity and are believed to dispel negative energies while inviting positive vibrations into sacred spaces like temples and homes.[68]In Southeast Asian customs, Murraya paniculata, or orange jasmine, features in traditional practices emphasizing warding off malevolent forces through ritual applications. Communities employ its fragrant elements in ceremonies to invoke protection and harmony, reflecting the plant's auspicious status in regional folklore.Historical references to Murraya species appear in ancient Chinese texts, including the traditional pharmacopeia, where plants like M. exotica and M. paniculata are noted for their medicinal applications in traditional Chinese medicine as recorded in ancient texts, signifying their enduring value in promoting health and well-being.[69]
Notable Modern References
In 2021, the genusMurraya entered mainstream public consciousness through the Scripps National Spelling Bee, where 14-year-old Zaila Avant-garde from Harvey, Louisiana, correctly spelled "murraya"—defined as a genus of tropical Asiatic shrubs in the rue family—as the championship word in the 18th round, securing her victory as the first African American champion in the competition's 96-year history.[70] The event, broadcast live on ESPN, drew widespread media coverage highlighting Avant-garde's achievement and the obscurity of the botanical term to general audiences.[71][72]This spelling bee triumph amplified interest in Murraya beyond academic circles, with subsequent discussions in popular outlets emphasizing its role as an ornamental and aromatic plant genus.[73] Coinciding with this publicity, a comprehensive taxonomic revision of Murraya sensu stricto was published in August 2021, employing molecular phylogeny and morphological analysis to recognize eight species worldwide, including a new combination and lectotype designations, thereby updating the genus's classification in contemporary botany.[12] The revision, appearing in the journal Taiwania, underscored ongoing refinements in Rutaceae taxonomy and contributed to heightened scholarly attention for the genus during that year.[74]