Fact-checked by Grok 2 weeks ago

Musical hallucinations

Musical hallucinations are a form of complex auditory hallucination characterized by the perception of melodies, music, or songs in the absence of any external auditory stimulus.^[1] These perceptions typically involve familiar tunes, such as childhood songs or popular melodies, and can last from seconds to hours, often originating from one or both ears.^[2] They are relatively rare, with a reported prevalence of about 0.16% in general hospital populations, and more commonly affect older adults, particularly females, with an average onset age around 56 years.^[1]^[3] The etiology of musical hallucinations is multifaceted, frequently linked to auditory deprivation such as hearing loss, where the brain compensates by generating internal sounds—a phenomenon sometimes termed musical ear syndrome or auditory Charles Bonnet syndrome.^[1]^[2] Neurological conditions play a significant role, including neurodegenerative disorders like Parkinson's disease and Lewy body dementia, epilepsy, brain lesions (often in the temporal lobe), and cerebral atrophy, accounting for about 25% of cases.^[3] Psychiatric factors, such as schizophrenia or depression, as well as medication side effects (e.g., from antihypertensives or tramadol) and toxic-metabolic issues, can also trigger them, though hearing impairment remains the most common association, present in up to 67% of unclassified cases.^[1]^[3] Clinically, musical hallucinations vary in emotional impact, ranging from neutral or pleasurable to distressing, and may be lateralized to the better-hearing ear in those with asymmetric hearing loss.^[1] Diagnosis involves ruling out psychiatric or cognitive disorders through medical history, audiological evaluation, and imaging like CT or MRI to identify underlying causes.^[2] There is no specific cure, but management focuses on treating the root cause—such as fitting hearing aids for auditory deprivation, discontinuing offending medications, or addressing neurological issues—while supportive measures like cognitive behavioral therapy, environmental sound enrichment, or medications (e.g., carbamazepine or antidepressants) may alleviate symptoms in refractory cases.^[1]^[2] The content of the perceived music often reflects the individual's background, with religious or patriotic tunes common in neurodegenerative cases and mood-congruent selections in psychiatric ones, highlighting the interplay between brain pathology and personal experience.^[3]

Introduction

Definition and Characteristics

Musical hallucinations (MH) are a type of complex auditory hallucination characterized by the perception of music, melodies, or songs in the absence of an external auditory stimulus.^[1] Unlike basic auditory perceptions, MH involve organized, structured sounds that mimic real music, often perceived as vivid and immersive.^[4] This phenomenon is distinct from voluntary musical imagery, as it occurs involuntarily and without conscious control.^[5] Key features of MH include their stereotypical and repetitive nature, where familiar tunes—such as childhood songs, religious hymns, or popular melodies—replay continuously or intermittently.^[4] The content is typically non-verbal but can incorporate instruments like piano or organ, and occasionally singing with lyrics, though purely instrumental forms are common.^[1] Duration varies widely, from brief episodes lasting seconds to persistent experiences extending for hours, days, or even continuously in chronic cases.^[4] In most instances, individuals retain insight, recognizing the music as internally generated rather than external, which differentiates MH from more delusional perceptual disorders.^[4] MH differ from simple tinnitus, which involves unorganized tones or noises without melodic structure, whereas MH feature recognizable, complex harmonies and rhythms.^[6] They also contrast with auditory verbal hallucinations, which primarily entail spoken words or voices rather than musical elements, though both fall under broader auditory hallucinations.^[7] Historically, MH associated with auditory deprivation, such as hearing loss, have been termed auditory Charles Bonnet syndrome, analogous to visual hallucinations in the visually impaired.^[1]

Clinical Presentation

Patients with musical hallucinations typically perceive familiar tunes, songs, hymns, or instrumental music in the absence of external auditory stimuli, often describing the experience as hearing a radio or live performance internally. These perceptions are usually bilateral but can be louder in quieter environments or predominantly in the ear with greater hearing impairment. The content frequently includes recognizable pieces from the patient's past, such as childhood songs or popular melodies, and may last from seconds to hours.^[8]^[1] Subjective experiences vary, with the music sometimes evoking positive emotions like comfort or nostalgia, while in other cases it triggers distress, anxiety, or frustration due to its intrusiveness. Most patients demonstrate preserved insight, recognizing the unreality of the sounds, though a subset—particularly those with comorbid cognitive impairment—may lack awareness and attribute the music to external sources like neighbors or devices, potentially leading to secondary delusions. This insight often allows patients to differentiate the hallucinations from reality, reducing associated fear.^[8]^[9]^[1] Variations in presentation include simple forms, such as single notes or instrument tones, versus complex orchestrations with multiple layers, vocals, and rhythms. Episodes can be intermittent or continuous, with some persisting throughout the day without voluntary control, and unilateral manifestations occasionally occur in cases linked to focal brain lesions. Musical hallucinations are frequently associated with hearing loss, which may exacerbate their prominence.^[8]^[1] The impact on daily life ranges from negligible, where patients adapt and even enjoy the experience, to significant interference with concentration, sleep, and social interactions in more severe instances, potentially causing isolation or relational conflicts. For example, bothersome tunes may disrupt conversations or lead to repeated checks for external sources, heightening emotional burden.^[9]^[8]

Epidemiology

Prevalence and Incidence

Musical hallucinations (MH) are considered rare in the general population, with point prevalence estimates ranging from 0.16% in psychiatric inpatients at general hospitals to higher rates in community surveys of older adults. A seminal study screening 3,678 psychiatric patients reported a prevalence of 0.16%, highlighting MH as an uncommon presentation in clinical settings. In psychiatric outpatient settings, prevalence is notably higher; one study of 190 patients reported 26.8% experiencing musical hallucinations, rising to 41% among those with obsessive-compulsive disorder.^[10] In broader epidemiological contexts, lifetime prevalence in non-clinical populations remains poorly quantified due to underreporting, often attributed to misdiagnosis as tinnitus or reluctance to disclose due to stigma associated with hallucinations.^[11]^[9] Incidence is notably elevated among specific at-risk groups, particularly those with hearing impairment. Among elderly individuals (aged 65 and older) presenting with audiological complaints, prevalence rates range from 0.86% to 2.5% based on systematic reviews of clinical surveys. In patients referred for audiometric evaluation, primarily with mild to moderate hearing loss, the prevalence reaches 3.6%, with associations to female gender and left-sided hearing asymmetry. A comprehensive review of 393 documented MH cases found that 67.2% involved hearing impairment, underscoring its role as the most common predisposing factor across etiologies.^[12]^[13]^[3] MH are exceedingly rare in children and adolescents, with case reports suggesting occurrences primarily in the context of neurological or psychiatric conditions rather than isolated auditory deprivation. Overall trends indicate increasing clinical recognition, driven by aging global populations and improved audiologic screening, though exact incidence rates remain elusive without large-scale prospective studies. A consistent female predominance is observed in aggregate data, though it appears more pronounced in hearing-impaired cohorts.^[14]^[4]

Demographic Patterns

Musical hallucinations predominantly affect older adults, with a mean age of onset around 60 to 70 years across multiple studies. For instance, in a review of 77 cases, the mean age was 68.1 years (range: 22–97 years), while a larger analysis of 226 subjects reported a mean of 67.9 years (range: 20–101 years). Cases under 50 years are rare, often linked to specific neurological or psychiatric conditions, and prevalence peaks in those over 80 years, particularly among individuals experiencing sensory decline such as hearing impairment.^[4]^[15] A slight female predominance is consistently observed, with women comprising 60% to 70% of reported cases. Studies show this pattern as 65.4% female in a cohort of 393 subjects, 66.8% in 226 cases, 70% in 132 patients, and 76.3% in 77 cases. This disparity may relate to women's longer average lifespan or differences in reporting behaviors, though direct causal links remain unestablished.^[3]^[15]^[16]^[4] Comorbidities are common among affected individuals, with high overlap for hearing loss reported in approximately 71% of cases in certain cohorts, such as 67.2% among those without clear neurological classification. Dementia affects 10% to 20% of patients, including forms like Lewy body dementia, while psychiatric histories, such as depression or schizophrenia, appear in 20% to 47% of cases depending on the subgroup analyzed. Isolated musical hallucinations without these comorbidities occur but are less frequent, often in otherwise healthy elderly individuals.^[3]^[4]^[15] Cultural factors influence the content of musical hallucinations, which typically feature familiar tunes from the individual's background, such as religious hymns, childhood songs, or national anthems in their native language. In predominantly Western study populations, the perceived music often consists of classical or popular tunes from that cultural context, though no significant ethnic or racial disparities in overall prevalence have been identified.^[4]

Etiology

Auditory Deprivation

Musical hallucinations arising from auditory deprivation primarily occur in individuals with significant hearing loss, where the brain compensates for reduced sensory input through spontaneous neural activity in the auditory cortex. This phenomenon is analogous to Charles Bonnet syndrome in the visual domain, where sensory deprivation leads to perceptual experiences without external stimuli. The deafferentation hypothesis posits that the loss of peripheral auditory input results in central hyperactivity within the auditory pathways, lowering the threshold for spontaneous firing and generating perceived music in the absence of real sound sources.^[1]^[17] Evidence strongly links auditory deprivation to musical hallucinations, with up to 67% of cases without identifiable neurological or psychiatric causes associated with hearing impairment, often confirmed by audiometric testing.^[3] These hallucinations tend to worsen in cases of profound deafness, as the greater degree of sensory loss amplifies the brain's compensatory mechanisms, and they are commonly termed "musical ear syndrome" when tied to hypoacusis.^[18] A specific subtype involves unilateral hearing loss, which frequently produces ipsilateral musical hallucinations, localized to the side of the impaired ear. For instance, case reports describe children and adults experiencing auditory perceptions exclusively on the affected side, supporting the role of localized deafferentation in triggering these symptoms.^[19] Improvement is observed in many cases through restoration of auditory input; hearing aids can lead to partial or complete resolution in some affected individuals by reducing sensory deprivation, while cochlear implants show variable but often beneficial outcomes in severe cases.^[20]^[21]

Neurological Disorders

Musical hallucinations can arise from various structural and functional abnormalities in the brain, particularly those affecting the auditory processing pathways. Focal lesions, such as those resulting from strokes or tumors in the temporal lobe, are among the common neurological causes, often involving irritation or disruption of key auditory regions like Heschl's gyrus. These lesions may lead to "release hallucinations," where inhibitory mechanisms fail, allowing spontaneous activation of stored musical memories without external stimuli. In a retrospective review of 393 cases, approximately 9% of musical hallucinations were attributed to focal brain lesions, predominantly in the left temporal lobe, highlighting their role in generating complex auditory percepts.^[3] Epilepsy, especially temporal lobe seizures, represents another significant neurological etiology, where musical hallucinations may manifest as an ictal aura, interictal phenomenon, or postictal event. Mechanisms involve aberrant electrical activity in the auditory cortex and limbic structures, often detectable via EEG as spike-wave discharges or desynchronization in temporal regions. A systematic review identified 24 detailed cases linking epilepsy to musical hallucinations out of 983 epilepsy patients, with temporal lobe involvement predominant; for instance, patients reported hearing familiar songs like Italian tunes during seizures originating from mid-temporal spikes. In some epileptic cases, symptoms mimic familiar music and resolve with antiepileptic medications such as carbamazepine or surgical intervention, underscoring the reversible nature of seizure-related hallucinations.^[22] Migraines with aura occasionally feature auditory components, including rare instances of musical hallucinations, likely due to transient cortical spreading depression affecting auditory pathways or serotonin-mediated perceptual alterations.^[23] Case series document auditory hallucinations during migraine attacks, with durations typically under one hour and improvement alongside headache prophylaxis in over half of affected individuals; while voices predominate, musical elements have been reported in select cases without progression from visual auras. Overall, neurological disorders account for about 25% of musical hallucinations in large cohorts, with EEG abnormalities and lesion-specific imaging providing diagnostic correlates.^[24]^[3]

Psychiatric Conditions

Musical hallucinations (MH) occur in association with several psychiatric disorders, most notably major depressive disorder, schizophrenia, and obsessive-compulsive disorder (OCD), though they are less common overall in psychiatric populations compared to neurological etiologies. In a systematic analysis of 294 reported cases, psychiatric conditions accounted for 28.9% of MH instances, with major depressive disorder representing 30.6% of those psychiatric cases and schizophrenia or related psychoses comprising 47.1%.^[15] Prevalence within specific disorders varies; for example, a study of 100 schizophrenic inpatients found that 16% experienced MH, often as part of broader auditory phenomena.^[25] In contrast, MH appear in approximately 26.8% of psychiatric outpatients across diagnoses, rising to 41% among those with OCD, where they may correlate with comorbid anxiety or social phobia.^[10] Anxiety disorders show lower associations, with only 2.4% of psychiatric MH cases linked to them in the same review.^[15] Mechanisms underlying MH in psychiatric contexts likely involve disruptions in neural circuits related to auditory processing and emotional regulation. In schizophrenia, dopaminergic hyperactivity in mesolimbic pathways may contribute to the release of stored musical memories, akin to general auditory hallucinations, though MH specifically engage temporal lobe structures like the superior temporal gyrus.^[3] For mood disorders such as depression, stress-induced alterations in the auditory cortex, potentially exacerbated by medication non-compliance (e.g., abrupt cessation of antidepressants), can trigger MH as a secondary symptom.^[26] These hallucinations often arise with preserved insight, distinguishing them from typical verbal hallucinations in psychosis, where patients may lack awareness of internal origin; individuals with MH frequently recognize the percepts as unreal and report them as less intrusive or ego-dystonic.^[27] Evidence from clinical studies highlights MH as a potential indicator of underlying mood fluctuations in psychiatric patients, particularly the elderly. In one cohort of 81 patients with MH, approximately 6% exhibited rare secondary delusions tied to the hallucinated content, such as attributing religious hymns or Christmas carols to external sources during manic episodes, leading to temporary lack of insight.^[9] Unlike more distressing verbal hallucinations, MH in these settings are often bearable and may resolve with treatment of the primary disorder, such as antipsychotics like risperidone, underscoring their role as a marker rather than a core psychotic feature.^[9] This preserved insight and lower distress level facilitate differentiation and management in psychiatric care.

Pharmacological and Toxic Factors

Musical hallucinations can arise as an adverse effect of various pharmacological agents, disrupting normal auditory processing through alterations in neurotransmitter systems. Common triggers include antidepressants, which account for approximately 18.5% of reported drug-induced cases, often involving selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants like paroxetine, mirtazapine, imipramine, and clomipramine.^[28] These medications enhance serotonin, norepinephrine, or dopamine activity, potentially leading to hyperexcitability in auditory cortical regions.^[28] Antipsychotics have also been implicated in isolated cases, though less frequently, with mechanisms tied to dopaminergic modulation.^[29] Benzodiazepine withdrawal represents another key pharmacological factor, inducing rebound central nervous system excitation due to diminished GABA-mediated inhibition, which can manifest as auditory phenomena including music.^[28] Specific agents like lorazepam, temazepam, lormetazepam, and triazolam have been associated with such symptoms during abrupt cessation.^[29] Alcohol withdrawal, often progressing to delirium tremens, similarly triggers hyperexcitability in auditory pathways, with musical elements reported in alcoholic hallucinosis; for instance, one case series documented songs and hymns emerging 2-3 days post-abstinence.^[28] Illicit drugs contribute sporadically, with ketamine (an NMDA antagonist) linked to dissociative states featuring familiar tunes like "You'll Never Walk Alone," comprising 11.1% of intoxication cases in a review.^[28] Cocaine and LSD may induce broader hallucinatory experiences, but musical specificity remains rare in documented reports.^[30] Evidence from case reports underscores rapid onset, often within days of initiating or withdrawing from these agents, affecting a mean age of 58.3 years and predominantly females (67.9%).^[28] Resolution occurs in 88.9% of instances upon discontinuation or dose adjustment, higher than in non-pharmacological etiologies, supporting causality.^[28] Opioids (e.g., tramadol, oxycodone) and antifungals like voriconazole also feature prominently, at 11.1% each, via dopamine enhancement or central penetration, respectively.^[28] Elderly patients face elevated risk due to polypharmacy, amplifying neurotransmitter imbalances and interactions that sensitize auditory networks.^[29] Toxic exposures, such as carbon monoxide poisoning, can provoke auditory hallucinations through hypoxia-induced cortical dysfunction, though musical variants are less commonly specified.^[31] Overall, these factors highlight the role of reversible pharmacological perturbations in musical hallucinations, distinct from structural brain changes.

Other Risk Factors

Metabolic disturbances represent a less common but documented contributor to musical hallucinations, often through systemic impacts on neural function. Vitamin B12 deficiency has been associated with auditory hallucinations in case reports of neuropsychiatric presentations, potentially due to demyelination and altered neuronal excitability in auditory pathways, though specific musical content is infrequently detailed.^[32] Thyroid dysfunction, particularly in the context of Hashimoto's encephalopathy, can precipitate musical hallucinosis by inducing autoimmune-mediated inflammation that disrupts temporal lobe processing, as evidenced in isolated cases where symptoms resolved with thyroid hormone replacement and immunosuppression.^[33] Electrolyte imbalances, such as hyponatremia or hypercalcemia, may exacerbate neural hyperexcitability, leading to auditory phenomena including music-like perceptions, typically in the setting of broader metabolic derangements. These factors account for a minority of cases, estimated at under 5% in clinical series of auditory hallucinations, with anemia occasionally implicated in rare reports of perceptual distortions that mimic hallucinatory experiences. Infectious processes, such as encephalitis, have been linked to musical hallucinations through direct central nervous system involvement, altering auditory cortex activity via inflammation or post-infectious sequelae. For instance, rhomboencephalitis and Lyme disease can trigger persistent musical percepts by affecting brainstem structures responsible for auditory gating, with case evidence showing resolution upon antimicrobial treatment.^[34]^[35] Post-viral states may contribute via residual neuroinflammation that heightens spontaneous neural firing in auditory networks, though such associations remain anecdotal and represent fewer than 10% of reported etiologies in systematic reviews of hallucination triggers. Age-related decline, independent of profound hearing loss, increases susceptibility to musical hallucinations, particularly in multimorbid elderly individuals where cerebral atrophy and subtle sensory-cognitive impairments converge. Inhibitory deficits in prefrontal and temporal regions can lead to disinhibition of stored musical memories, manifesting as involuntary tunes without external stimuli, with prevalence up to 2.5% in older adults undergoing audiometric evaluation.^[12] This vulnerability is heightened in those with social isolation or mild cognitive changes, where systemic effects like reduced neural reserve amplify perceptual errors, comprising a notable subset of community-based cases among seniors. Emerging evidence points to transient triggers like fatigue and sleep deprivation as precipitating factors for musical hallucinations even in otherwise healthy individuals, likely by impairing auditory processing and lowering the threshold for spontaneous activations in memory circuits. In non-clinical populations, severe sleep loss has been reported to induce music-like auditory experiences, resolving with rest, underscoring the role of temporary neural exhaustion in modulating hallucination risk.

Diagnosis

Clinical Evaluation

The clinical evaluation of musical hallucinations begins with a thorough history taking to characterize the auditory symptoms, their onset, potential triggers, level of insight, and functional impact. Patients typically describe hearing melodies, songs, or instrumental music without an external source, often familiar tunes such as childhood songs or popular melodies, which may loop repetitively or vary in complexity.^[1] The onset is frequently insidious but can be sudden, particularly in association with auditory deprivation or neurological events, and symptoms may last from minutes to hours daily.^[29] Triggers commonly include periods of silence, removal of hearing aids, or stress, with many patients reporting exacerbation in quiet environments due to underlying hearing loss.^[29] Insight is often preserved, allowing individuals to recognize the music as internally generated rather than real, though some may initially attribute it to external sources like radios or neighbors, leading to social embarrassment or isolation.^[1] Assessment should also explore the emotional distress and interference with daily activities, such as sleep disruption or concentration difficulties, to gauge severity and need for intervention.^[29] A comprehensive physical and neurological examination follows, prioritizing audiometric testing to evaluate hearing status, as sensorineural hearing loss is present in up to 60-80% of cases and serves as a key etiological clue.^[29] Standard audiometry, including pure-tone thresholds and speech recognition, helps quantify deficits, such as moderate to severe bilateral loss, which may correlate with symptom intensity.^[36] The mental status examination assesses insight into the hallucinatory nature of the experience, screens for concurrent delusions or affective symptoms, and evaluates cognitive function using tools like the Mini-Mental State Examination (MMSE) to rule out dementia-related contributions.^[36] A focused neurological screening is essential to detect focal signs, such as hemiparesis or sensory deficits, that might suggest underlying lesions, epilepsy, or vascular events, while an ear, nose, and throat (ENT) evaluation excludes peripheral auditory pathologies.^[29] Differential diagnosis requires distinguishing musical hallucinations from similar conditions through targeted history and examination findings. Unlike simple tinnitus, which involves non-musical tones or buzzing without melodic structure, musical hallucinations feature complex, organized auditory content; audiometry and symptom description aid this differentiation.^[1] Seizures, particularly temporal lobe epilepsy, must be excluded via clinical history of ictal features and, if indicated, EEG, as musical phenomena rarely occur in isolation without other epileptic signs.^[29] Delirium is ruled out by assessing for fluctuating cognition, inattention, and acute confusional states absent in isolated musical hallucinations.^[36] Other considerations include obsessive-compulsive disorder with musical obsessions, characterized by intrusive thoughts rather than perceptual experiences, evaluated using scales like the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for resistance and compulsions.^[29] The Psychotic Symptom Rating Scales (PSYRATS), particularly the auditory hallucinations subscale, can quantify severity dimensions such as frequency, duration, and distress in broader hallucinatory contexts, though adaptation for musical content may be needed.^[37] Red flags prompting urgent evaluation include sudden onset, particularly with accompanying neurological symptoms like headache, focal weakness, or altered consciousness, which may indicate acute cerebrovascular events or tumors; lack of insight suggesting possible psychiatric decompensation; or rapid progression impacting daily functioning, necessitating prompt neuroimaging if indicated.^[1]

Neuroimaging and Laboratory Findings

Neuroimaging plays a crucial role in identifying structural and functional abnormalities associated with musical hallucinations (MH), particularly to detect underlying neurological etiologies. Magnetic resonance imaging (MRI) and computed tomography (CT) scans are commonly employed to evaluate for lesions, with frequent involvement of temporal and occipital regions observed in cases linked to cerebrovascular pathology or tumors. For instance, structural lesions such as ischemic infarctions in the left frontal lobe, right frontotemporal strokes, or pontine lacunar infarcts have been documented in MH patients. In a systematic review of 393 cases, approximately 9% exhibited structural brain lesions correlating with the hallucinations.^[4]^[3] Functional imaging techniques, including positron emission tomography (PET) and functional MRI (fMRI), reveal hyperactivity in the auditory cortex during MH episodes, supporting theories of aberrant neural activation. Hypometabolism in temporal regions has been noted in PET studies of MH related to auditory deprivation, such as in profound deafness, while hyperperfusion in auditory and frontal areas appears in epileptic cases. Neuroimaging is often normal in up to half of isolated auditory deprivation cases, underscoring the role of deafferentation without overt pathology. A 2024 review of functional imaging highlighted widespread activation in the superior temporal sulcus, basal ganglia, and prefrontal cortex, emphasizing deafferentation patterns in hearing-impaired patients.^[38]^[15] Laboratory investigations typically include toxicology screens to identify pharmacological triggers, such as amiodarone or selective serotonin reuptake inhibitors, alongside assessments of electrolytes, vitamin B12, and thyroid function to rule out metabolic contributors. These tests are generally unremarkable in primary MH but essential for excluding deficiencies or toxicities that may precipitate symptoms, as B12 deficiency has been linked to auditory hallucinations in broader contexts. Electroencephalography (EEG) is utilized to detect epileptiform activity, particularly in suspected temporal lobe epilepsy, though findings are normal in many non-epileptic cases and abnormalities do not always correlate directly with hallucination onset.^[4]^[39] Overall, these objective tests guide etiological diagnosis by confirming lesions in a minority of cases and highlighting functional correlates of deafferentation, integrating with clinical history to differentiate MH from other auditory phenomena. Recent studies, including a 2024 analysis, advocate for advanced functional imaging to better delineate neural mechanisms in deafferentation-driven MH.^[15]^[22]

Treatment and Management

Addressing Underlying Causes

Addressing the underlying causes of musical hallucinations is the primary therapeutic approach, as targeted interventions often yield the highest rates of symptom resolution by correcting the precipitating factor. This strategy is particularly effective for reversible etiologies, where success rates can exceed 80% upon resolution of the root condition. Recent research from 2024-2025 emphasizes etiology-specific management, with otologic treatments showing notable improvements in auditory deprivation cases. In cases stemming from auditory deprivation, such as profound hearing loss, the provision of hearing aids or cochlear implants aims to restore sensory input and mitigate the deafferentation that triggers hallucinations. Digital hearing aids are recommended as an initial, non-invasive option to amplify external sounds, while cochlear implants are considered for severe, bilateral sensorineural loss unresponsive to amplification. A 2025 study of nine patients with post-lingual hearing loss reported subjective symptom improvement in 67% of cases following audiological rehabilitation, including hearing aids in eight patients and cochlear implantation in one.^[40] For neurological disorders, treatments focus on stabilizing aberrant neural activity or removing structural abnormalities. Antiepileptic drugs, such as carbamazepine, are effective for musical hallucinations associated with epilepsy, particularly those involving temporal lobe foci, with a mean treatment response indicating partial to complete resolution in reviewed cases. Surgical resection of epileptogenic lesions or tumors has led to complete disappearance of symptoms in approximately 70% of documented instances involving brain pathology. Radiation therapy may be employed for inoperable lesions, though evidence is more limited and typically combined with pharmacological management. In migraine-related musical hallucinations, prophylactic agents like topiramate or propranolol can parallel the resolution of headache episodes with auditory symptoms, as auditory hallucinations often abate with migraine control.^[29]^[41] Psychiatric conditions and pharmacological or toxic factors require adjustment of underlying contributors, such as mood disorders or substance exposure. Medication review and discontinuation of offending agents— including certain antidepressants with anticholinergic properties or other drugs like opioids and antiparkinsonian agents—are prioritized, often leading to rapid symptom cessation. Detoxification protocols are essential for intoxication cases, with supportive care to manage withdrawal. If mood disturbances are comorbid, selective serotonin reuptake inhibitors like paroxetine may be initiated to address depressive elements, showing moderate efficacy in targeted psychiatric presentations. A 2024 analysis of 27 drug-induced cases found complete resolution in 88.9% following dose reduction, termination, or switching of the causative medication.^[28]^[29] Overall, etiology-specific interventions demonstrate high efficacy, with up to 97% resolution in reversible pharmacological causes and 67-70% improvement in otologic and neurological cases per systematic reviews and recent cohort studies. When the underlying cause remains unclear, symptomatic therapies may provide adjunctive relief.^[29]^[40]

Symptomatic Therapies

Symptomatic therapies for musical hallucinations are employed when the underlying etiology is unclear, untreatable, or insufficiently responsive to causal interventions, aiming to alleviate the perceptual experience directly. These approaches include both pharmacological and non-pharmacological strategies, with evidence primarily derived from case reports and small series due to the rarity of the condition. Treatment selection often considers patient age, comorbidities, and symptom severity, prioritizing low-risk options to avoid adverse effects, particularly in older adults.^[42] Pharmacological options focus on modulating neurotransmitter activity to reduce hallucination intensity. Low-dose antipsychotics, such as risperidone (typically 0.5–2 mg daily), have shown efficacy in multiple cases, leading to symptom reduction within days to weeks; for instance, risperidone resolved musical hallucinations in a patient with vascular depression and in elderly individuals with hearing impairment. Antidepressants, including selective serotonin reuptake inhibitors like escitalopram and tricyclic agents such as clomipramine, have been effective in cases linked to obsessive-compulsive features or mood disorders, with complete resolution reported in up to 50% of treated instances in reviews of hypoacusis-related cases. Benzodiazepines, like clonazepam, have provided short-term relief in some reported cases of musical hallucinations by enhancing GABAergic inhibition, though their use is limited to brief durations to prevent dependence. Acetylcholinesterase inhibitors, such as donepezil or rivastigmine, demonstrate promise in persistent cases associated with cognitive decline, achieving symptom improvement in over 70% of reported hypoacusis patients. Polypharmacy should be avoided in the elderly to minimize risks like sedation and falls.^[42]^[43]^[42]^[44] Non-pharmacological interventions emphasize coping mechanisms and sensory modulation. Cognitive behavioral therapy (CBT) helps patients develop strategies to manage distress and preserve insight into the hallucinatory nature of symptoms, with case reports indicating reduced severity in psychiatric contexts; recent analyses underscore its role in maintaining psychological well-being without pharmacological side effects. Sound therapy, involving white noise generators or ambient radio/music to mask internal perceptions, provides partial relief in 40–60% of hypoacusis cases by enriching auditory input. Emerging non-invasive neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), have shown promise in isolated medication-resistant cases. Reassurance that musical hallucinations are typically benign and non-psychotic fosters adaptation, often leading to spontaneous attenuation without further intervention. These methods are particularly suitable for mild, persistent symptoms.^[42]^[4]^[42]^[44]^[4] Overall evidence for symptomatic therapies is variable, with improvement rates ranging from 20–60% across pharmacological and non-drug approaches, based on aggregated case outcomes rather than controlled trials. Many episodes self-limit within months, rendering long-term management unnecessary, though rare persistent cases may require ongoing multimodal care. Addressing underlying causes remains the first-line strategy when feasible.^[42]^[4]^[44]

History and Research

Historical Descriptions

Musical hallucinations have been documented in medical literature since the mid-19th century, with early reports often associating the phenomenon with psychiatric conditions or neurological disorders such as epilepsy. The first known description appeared in 1844, when French psychiatrist Jules-Gabriel-François Baillarger reported cases of auditory hallucinations involving melodies in patients with mental illness. By 1881, Emmanuel Régis, another French psychiatrist, explicitly termed these experiences "musical hallucinations," noting their occurrence in individuals with hearing impairment or delirium. In 1883, James Ormerod described a case of a 61-year-old woman with progressive deafness and epilepsy who perceived songs and spoken words as hallucinatory auditory experiences, highlighting an early link between the condition, sensory loss, and seizure disorders.^[22]^[1] These initial accounts frequently misinterpreted musical hallucinations as symptoms of insanity, leading to psychiatric misdiagnosis, though some clinicians recognized their association with epilepsy or organic brain pathology. In religious and cultural contexts predating formal medical terminology, similar experiences were often interpreted as divine encounters, such as hearing angelic choirs or heavenly music, as recounted in historical spiritual narratives. During epilepsy surgeries in the 1950s, neurosurgeon Wilder Penfield advanced understanding by electrically stimulating the temporal lobes of awake patients, eliciting vivid auditory hallucinations including fragments of music and familiar tunes, which supported the role of the temporal cortex in generating such percepts.^[22]^[1]^[45] The 1970s brought increased attention to musical hallucinations in deaf individuals, with case reports emphasizing their emergence amid profound hearing loss rather than psychosis. For instance, Rosenbaum and Siegel documented two elderly patients with longstanding deafness who suddenly "heard" elaborate orchestral music, underscoring the phenomenon's non-delusional nature and its prevalence in sensory deprivation. A key milestone in the 1980s and early 1990s was the work of German Berrios, who in 1990 analyzed 46 cases from historical literature and new observations, classifying musical hallucinations as typically non-psychotic and often tied to deafness, aging, or brain lesions in the non-dominant hemisphere, thereby shifting focus from psychiatric stigma to neurological evaluation and reducing misdiagnosis rates.^[45]^[46] This foundational historical perspective laid the groundwork for later refinements in classification and etiology.^[46]

Recent Advances

In the 2010s, functional neuroimaging studies provided key evidence supporting deafferentation as a core mechanism in musical hallucinations, particularly in cases linked to hearing loss, where reduced sensory input leads to spontaneous auditory cortex activity.^[47] A 2017 review of 23 cases highlighted activations in the superior temporal sulcus and other cortical regions, consistent with release from inhibitory controls due to peripheral deafferentation.^[47] This was further corroborated in a 2021 study using magnetoencephalography, which demonstrated heightened spontaneous activity in the auditory cortex following deafferentation in patients with schizophrenia-spectrum disorders experiencing auditory hallucinations, including musical variants.^[17] These findings shifted understanding from purely psychiatric models toward integrated sensory-neural explanations. Recent studies from 2023 to 2025 have advanced distinctions between musical hallucinations and related phenomena, such as musical tinnitus—a variant characterized by repetitive, non-distressing musical percepts often tied to otologic factors—and auditory Charles Bonnet syndrome (aCBS), where deafferentation from profound hearing loss triggers complex auditory illusions.^[7] A 2024 prospective study of 15 patients with musical tinnitus (mean age 74.1 years, 80% female) linked it primarily to age-related hearing loss, with no active psychiatric comorbidities in most cases, differentiating it from symptomatic musical hallucinations.^[7] Concurrently, a 2025 analysis reported auditory illusions, including musical elements, in up to 16% of adults with hearing loss, often resolving or modulating post-cochlear implantation, underscoring aCBS as a deafferentation-driven entity.^[48] Treatment efficacy for otologic causes has shown promise, with a 2024 study demonstrating 86.7% subjective improvement in musical tinnitus symptoms after two years of tinnitus counseling and sound therapy (e.g., hearing aids), far surpassing pharmacotherapy's 32% response rate.^[7] Psychiatric overlaps were illuminated in a 2023 cohort study of 81 patients, where 6% experienced musical hallucinations accompanied by secondary delusions (e.g., attributing music to external sources like neighbors) and complete lack of insight, often tied to cognitive impairment and paranoia; risperidone (1-1.5 mg/day) reduced symptoms in three cases, while rivastigmine aided one.^[9] Research gaps persist, including a scarcity of randomized controlled trials (RCTs) due to the condition's rarity and heterogeneous etiologies, limiting robust evidence for interventions beyond case series.^[40] Studies remain predominantly Western-focused, with underrepresentation of non-Western populations, potentially overlooking cultural variations in musical percepts or prevalence.^[9] Emerging applications of AI for analyzing hallucination patterns, such as through speech-to-text modeling of auditory reports, hold potential but lack clinical validation. Future directions emphasize functional connectivity research via resting-state fMRI to map auditory-memory network disruptions, as seen in 2025 studies linking improved hallucinations to targeted neurofeedback.^[49] Personalized therapies, tailored to etiology (e.g., otologic restoration for deafferentation cases versus antipsychotics for delusional variants), are prioritized to enhance outcomes.^[9]

References

[1]
“Doctor, I Hear Music”: A Brief Review About Musical Hallucinations
Feb 28, 2017 · Musical hallucinations constitute a complex type of auditory hallucination characterized by perception of melodies, music, or songs.
[2]
What Is Musical Ear Syndrome (MES)?
### Summary of Musical Ear Syndrome (MES)
[3]
musical hallucinations and their relationship to neurological disease
Oct 7, 2015 · Musical hallucinations have been linked to multiple associated conditions, including psychiatric and neurologic disease, brain lesions, drug effect, and ...
[4]
[PDF] The phenomenon of musical hallucinations: An updated review
Feb 2, 2023 · Musical hallucinations (MHs) are a type of complex auditory hallucinations in which a person hears continuous or intermittent musical tones and ...
[5]
Musical hallucinations, musical imagery, and earworms
Musical hallucinations (MH) are less frequent, less controllable, less familiar, and less likely to include lyrics than earworms or imagery. MH are also less ...
[6]
Tinnitus and musical hallucinosis: the same but more - PubMed
Nov 15, 2013 · Musical hallucinosis is a more complex auditory phantom phenomenon not only limited to sound perception, but also containing semantic and musical content.
[7]
Characteristics and treatment outcomes of musical tinnitus
Sep 10, 2024 · Auditory verbal hallucinations (hearing voices) are the most common hallucinatory phenomena. Hearing songs or melodies without external ...<|control11|><|separator|>
[8]
Alive With the Sound of Music: A Case Series on Patients Presenting ...
Dec 12, 2014 · Musical hallucinations are a rare phenomenon that renders appropriate identification and treatment a challenge. This case series describes ...Missing: characteristics | Show results with:characteristics
[9]
Musical hallucinations, secondary delusions, and lack of insight
Sep 27, 2023 · In this study we seek to broaden our understanding of this rare type of musical hallucination that comes with secondary delusions and lack of insight.
[10]
Prevalence rate of musical hallucinations in a general hospital setting
Prevalence rate of musical hallucinations in a general hospital setting. Psychosomatics. 1998 Mar-Apr;39(2):175. doi: 10.1016/S0033-3182(98)71368-4.Missing: incidence | Show results with:incidence
[11]
The prevalence and phenomenology of auditory hallucinations ...
Auditory hallucinations are frequent in elderly subjects with hearing impairment and seem to be associated with younger age and asymmetrical hearing impairment.
[12]
Prevalence of musical hallucinations in patients referred ... - PubMed
Results: Out of 194 patients, most of whom had mild to moderate hearing loss, seven (3.6%) had musical hallucinations. Significant associations were found with ...
[13]
Musical hallucinations in normal children and adult non-psychiatric ...
Feb 2, 2009 · In this paper we demonstrate that musical hallucinations are not necessarily pathological and can occur as a normal experience in people (children and adults)
[14]
Classification of musical hallucinations and the characters along ...
Sep 19, 2024 · Musical hallucinations (MH) involve the false perception of music in the absence of external stimuli which links with different etiologies. The ...
[15]
The clinical spectrum of musical hallucinations - ScienceDirect
Musical hallucinations as a particular type of auditory hallucinations are a disorder of complex sound processing in which the perception is formed by ...
[16]
Spontaneous brain activity underlying auditory hallucinations in the ...
Auditory hallucinations, the perception of a sound without a corresponding source, are common in people with hearing impairment.
[17]
Phantom Concerts: Decoding Musical Ear Syndrome in Older Adults
Jun 13, 2025 · Case highlights unusual diagnosis marked by episodic, musical auditory hallucinations that worsen when the patient removes her hearing aids.
[18]
Unilateral auditory hallucinations in a boy with ipsilateral conductive ...
Unilateral auditory hallucinations in a boy with ipsilateral conductive hearing loss. ... 2009. Complex auditory musical hallucinations with ambivalent feelings.
[19]
Review Uncovers Associative Links Between Hearing Loss, Mental ...
Sep 28, 2016 · Unilateral auditory hallucination is mostly associated with ipsilateral hearing loss. In the above-mentioned cases, the majority did not have ...<|separator|>
[20]
Musical hallucinations: review of treatment effects - Frontiers
Musical hallucinations, like actual musical sounds, are associated with activity in an extensive network of interconnected brain areas. This network comprises ...
[21]
Musical hallucinations and their relation with epilepsy - PMC
Apr 10, 2019 · Epilepsy and musical hallucinations can be related in several ways, with the latter presenting as an aura/ictal phenomenon, or a post- or ...Missing: migraines | Show results with:migraines
[22]
Auditory hallucinations associated with migraine - PubMed
Conclusion: Paracusias uncommonly co-occur with migraine and usually feature human voices. Their timing and high prevalence in patients with depression may ...
[23]
Musical hallucinations and musical imagery: Prevalence and ...
100 schizophrenic inpatients were examined for the presence of musical hallucinations and musical imagery. 16 patients (mean age 34 yrs) responded positively.
[24]
Musical hallucinations: prevalence in psychotic and nonpsychotic ...
Results: Musical hallucinations occurred in more than one fifth of all diagnoses. The prevalence of musical hallucinations was highest in OCD patients (41%).
[25]
“Doctor, I Hear Music”: A Brief Review About Musical Hallucinations.
Golden EC, Josephs KA. Minds on replay: musical hallucinations and their relationship to neurological disease. Brain 2015; 138(Pt 12): 3793-802. CrossRef.
[26]
Musical hallucinations – a challenge for psychiatric therapeutical ...
Musical hallucinations, labeled as Oliver Sacks syndrome, occur in individuals with and without mental illness, and many patients tend to have intact reality ...
[27]
Drug-induced musical hallucination - PMC - PubMed Central - NIH
May 22, 2024 · In summary, the primary suspected trigger drugs for inducing musical hallucinations encompass antidepressants, antiparkinson drugs, opioids, ...
[28]
Musical hallucinations: review of treatment effects - PMC
Musical hallucinations occurring as part of a psychiatric disorder tend to respond well to psychopharmacological treatments targeting the underlying disorder.
[29]
Cocaine-Induced Psychosis - an overview | ScienceDirect Topics
There has also been cocaine-induced psychotic disorder or CIPD, involving primarily auditory and visual hallucinations as well as paranoia, in those who ...
[30]
Carbon Monoxide Toxicity Clinical Presentation: History, Physical ...
May 30, 2025 · Hallucination, confabulation. Agitation. Nausea, vomiting, diarrhea. Abdominal pain. Headache, drowsiness. Dizziness, weakness, confusion.Missing: musical | Show results with:musical<|control11|><|separator|>
[31]
Musical hallucination or musical obsession? A differential diagnosis ...
Jun 24, 2024 · Musical hallucinations (MH) are a subset of complex auditory hallucinations described as hearing music in the form of tunes or melodies, ...
[32]
Scales to measure dimensions of hallucinations and delusions
It is concluded that the PSYRATS are useful assessment instruments and can complement existing measures.Missing: musical | Show results with:musical
[33]
Musical hallucinations: a brief review of functional neuroimaging ...
Dec 19, 2016 · Musical hallucinations are uncommon phenomena characterized by intrusive and frequently distressful auditory musical percepts without an external source.
[34]
Acute Psychosis as Presenting Symptoms of Vitamin B12 Deficiency
Nov 30, 2024 · Out of the eight patients, most had delusions and a few were having hallucinations and abnormal agitated behavior, and none of them had a family ...
[35]
Audiological and Otologic Characteristics of Patients with Musical ...
Jul 14, 2025 · Essentially, musical hallucinations are believed to result from sensory deficits, akin to those seen in patients with Charles Bonnet syndrome or ...
[36]
Auditory hallucinations associated with migraine: Case series and ...
Dec 5, 2014 · Isolated observations have documented rare associations of migraine with auditory hallucinations. Unlike visual, somatosensory, language, ...
[37]
https://pubmed.ncbi.nlm.nih.gov/10473315/
[38]
Atypical antipsychotics for the treatment of musical hallucinations in ...
Risperidone is an effective antipsychotic which is commonly prescribed in elderly patients.[8] This regimen reduced the symptoms significantly within 2 months, ...
[39]
https://pmc.ncbi.nlm.nih.gov/articles/PMC11684554/
[40]
Musical Hallucinations in Deafness - JAMA Network
Feb 10, 1975 · Formed auditory hallucinations associated with acquired deafness have seldom been reported in the English literature.Missing: 1970s | Show results with:1970s<|control11|><|separator|>
[41]
Musical hallucinations. A historical and clinical study - PubMed
A sample of 46 subjects experiencing musical hallucinations was analysed - 10 new cases in addition to 36 culled from the literature.Missing: descriptions Sommer 1883
[42]
Musical hallucinations: a brief review of functional neuroimaging ...
Musical hallucinations are uncommon phenomena characterized by intrusive ... brain lesion, epilepsy, and intoxication/pharmacology. Their physiological ...
[43]
Auditory Illusions After Hearing Loss and Cochlear Implantation - PMC
Jun 19, 2025 · Musical Hallucinosis: Auditory Illusions After Hearing Loss and Cochlear Implantation ... Musical hallucinations treated with acetylcholinesterase ...
[44]
Brain Structural and Functional Neuroimaging Features are ...
Brain structural and functional neuroimaging features are associated with improved auditory hallucinations in patients with schizophrenia after real-time fMRI ...Missing: musical | Show results with:musical