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Mucilage

Mucilage is a gelatinous, high-molecular-weight, water-soluble substance primarily produced by nearly all plants, some microorganisms, and marine organisms, consisting mainly of complex polysaccharides such as galactans, mannans, and uronic acids that form a viscous, adhesive matrix.^[1]^[2] It is secreted from various plant parts, including roots, seeds, stems, and leaves, where it serves essential biological functions such as facilitating seed germination by lubricating root tips, enhancing soil water retention and microbial interactions, and providing protection against environmental stresses like heavy metal toxicity or desiccation. In marine environments, mucilage forms gelatinous aggregates from phytoplankton exudates, impacting ecosystems.^[1]^[3] Common plant sources include okra (Abelmoschus esculentus), flaxseed (Linum usitatissimum), aloe vera (Aloe barbadensis), and psyllium (Plantago ovata), each yielding mucilage with slightly varying compositions that influence its solubility and gelling properties.^[2] In terms of physical and chemical properties, mucilage exhibits high viscosity, swelling capacity, and emulsifying abilities due to its hydrophilic nature and molecular structure, which allows it to form gels or films upon hydration.^[2]^[4] These characteristics make it biodegradable, biocompatible, and nontoxic, positioning it as a sustainable alternative to synthetic polymers in various industries.^[3] Biologically, root mucilage acts as a biofilm matrix that shapes rhizosphere microbiomes, promoting nutrient uptake and plant resilience, while seed mucilage aids in dispersal and establishment in arid environments.^[1] Mucilage has diverse applications across food, pharmaceutical, and biomedical fields, leveraging its texturizing, stabilizing, and binding qualities; for instance, it serves as a natural thickener and emulsifier in food products, a drug delivery excipient in tablets and gels, and a component in nutraceuticals for its potential antidiabetic, anti-inflammatory, and wound-healing effects.^[2]^[3] In pharmaceuticals, plant-derived mucilages like those from linseed (Linum usitatissimum) are used for controlled-release formulations, while cactus (Opuntia ficus-indica) mucilage is applied as edible coatings to extend shelf life.^[4]^[5] Emerging research highlights its role in environmental applications, such as flocculants for wastewater treatment, underscoring its versatility as a renewable resource.^[6]

Definition and Properties

Definition

Mucilage is a thick, gluey, gelatinous substance primarily produced by plants and certain microorganisms, serving protective functions such as shielding against desiccation and pathogens, as well as adhesive roles in processes like seed dispersal.^[3] This naturally occurring material is secreted by specialized cells in plant tissues, including seeds, roots, and stems, and by microbial sources like certain protists and bacteria, where it aids in environmental adaptation and biofilm formation.^[2] Primarily composed of polysaccharides, mucilage functions as a hydrocolloid that swells upon contact with water to form a viscous, gel-like matrix without fully dissolving.^[7] The term "mucilage" originates from the Late Latin mucilago, meaning "musty or moldy juice," reflecting its slimy, viscous nature, and entered botanical usage in the 17th century to describe plant exudates.^[8] Unlike related plant substances, mucilage is distinctly hydrophilic, readily absorbing water to produce slippery, viscous solutions that provide lubrication and moisture retention.^[9] In contrast, gums are typically more rigid, forming true gels as pathological exudates from injured plant tissues, while resins are insoluble, hydrophobic compounds derived from oxidized plant secretions.^[10] This solubility profile underscores mucilage's role as a dynamic, water-interactive barrier rather than a structural or impermeable material.

Chemical Composition

Mucilage is primarily composed of complex polysaccharides, including galactomannans, arabinoxylans, pectins, and hemicelluloses, which often form heterogeneous mixtures with proteins (typically 2-12%), lipids (0.9-2.8%), and trace minerals such as calcium and magnesium.^[2]^[11]^[3] These polysaccharides are built from monosaccharide units like D-xylose, L-arabinose, D-galactose, L-rhamnose, D-glucose, and uronic acids (e.g., D-galacturonic or D-glucuronic acid), with the latter contributing to the material's overall anionic character through carboxyl groups.^[2]^[11]^[3] Structurally, mucilages consist of branched heteropolysaccharides featuring β-1,4-linked backbones (e.g., xylose in arabinoxylans) with side chains of neutral sugars and uronic acids, enabling high water affinity and gelation.^[2]^[3] The molecular weight of these polymers generally ranges from 10^5 to 10^7 Da, influencing their viscosity and solubility, though exact values vary with extraction conditions and source material.^[12]^[13] Composition exhibits significant variability depending on the plant source and tissue type; for instance, seed mucilages like those from chia (Salvia hispanica) are rich in xylose (up to 38.5%) and glucose (19.6%), forming glucomannans, while flaxseed (Linum usitatissimum) mucilages contain higher proportions of xylose (21-37%) and galactose (20-28%), predominantly as arabinoxylans.^[2]^[11] Root-derived mucilages, such as from okra (Abelmoschus esculentus), often feature more rhamnose and galacturonic acid in pectin-like structures, with up to 23% uronic acids.^[3]^[11] Identification and profiling of mucilage components rely on advanced analytical techniques, including nuclear magnetic resonance (NMR) spectroscopy for elucidating glycosidic linkages and branching patterns, and high-performance liquid chromatography (HPLC) coupled with derivatization for quantifying monosaccharide compositions.^[2]^[13]^[14] These methods, often combined with Fourier-transform infrared (FTIR) spectroscopy for functional group confirmation, provide detailed insights into the polymeric architecture without extensive hydrolysis.^[2]^[13]

Physical Properties

Mucilage exhibits a pronounced hydrophilic nature, primarily due to its polysaccharide backbone rich in hydroxyl groups, enabling rapid absorption of water and subsequent swelling. This property allows mucilage to absorb up to 40 times its weight in water, leading to substantial volume expansion (swelling indices typically 10-40) upon hydration, forming pseudoplastic gels that contribute to its role in water retention and structural support.^[15]^[16] The rheological characteristics of mucilage solutions are marked by high viscosity, typically ranging from 10 to 1000 cP in 1-5% aqueous dispersions, which increases with concentration and molecular weight. These solutions display shear-thinning behavior, where viscosity decreases under applied shear stress, facilitating flow during processing, alongside thixotropy that permits temporary structural breakdown followed by recovery at rest.^[2]^[17] Mucilage demonstrates thermal stability up to approximately 80-100°C, beyond which partial denaturation occurs, though the gel structure often reforms upon cooling due to reversible hydrogen bonding. Optimal functionality is observed at pH levels between 4 and 7, where viscosity and gelation are maximized, with deviations leading to reduced water-binding efficiency.^[2]^[18] Regarding solubility, mucilage is generally insoluble in organic solvents such as ethanol or acetone but readily disperses in water to form colloidal suspensions or viscous solutions. For instance, okra mucilage exemplifies pseudoplastic flow in aqueous media, exhibiting non-Newtonian behavior that enhances its dispersibility without aggregation in polar environments.

Natural Occurrence

In Plants

Mucilage production is widespread among vascular plants, occurring in numerous families, with surveys indicating 10–32% of species in arid/semiarid communities and higher rates, such as 61% in temperate grasslands, produce seed mucilage.^[19] It is also notable in certain aquatic plants, such as Brasenia schreberi, where mucilage forms part of the plant's structure.^[20] This polysaccharide-rich substance is typically secreted by specialized cells, including idioblasts and mucilage cells in seed coats and root caps, as well as glands in some tissues.^[2] Common sites of mucilage production include seeds, roots, leaves, and stems. In seeds, it is often found in the outer layers of the seed coat, as seen in myxospermy—where seeds exude mucilage upon hydration—in families such as Plantaginaceae, Acanthaceae, Linaceae, and Brassicaceae.^[2] Examples include psyllium (Plantago ovata) seeds, which yield 37–52% mucilage, and flax (Linum usitatissimum) seeds, with approximately 7.3% yield.^[2] Basil (Ocimum basilicum) seeds represent another myxospermous case, containing significant xylan content.^[2] In roots, mucilage is secreted primarily by root cap cells, facilitating tissue development; for instance, maize (Zea mays) root caps produce mucilage that contributes to root elongation.^[21] Leaves and stems also host mucilage, often in gel-like forms, as in aloe vera (Aloe vera) leaves and the cladodes of cacti such as Opuntia species, where it aids in water retention within tissues.^[2] Stems of plants like Basella alba yield around 6.20% mucilage.^[2] From an evolutionary perspective, mucilage secretion has developed through specialized structures like interconnected idioblasts in certain families, such as Malvaceae, and epidermal mucilaginous idioblasts in legumes of the Adesmia clade, highlighting adaptations in diverse plant lineages.^[22]^[23]

In Microorganisms and Marine Organisms

Mucilage production occurs in various microorganisms, particularly protists and bacteria, where it serves critical functions in motility and biofilm formation. In protists such as diatoms, mucilage is secreted as extracellular polymeric substances (EPS) embedded within silica frustules, facilitating gliding motility along substrates. For instance, raphid diatoms like Craspedostauros australis produce adhesive mucilage strands from the raphe slit in their cell wall, enabling rapid directional movement and attachment.^[24]^[25] This motility aids in resource acquisition, such as light, in benthic environments.^[26] Bacteria also synthesize mucilage-like EPS that contribute to biofilm architecture and environmental adaptation. In species like Pseudomonas aeruginosa, exopolysaccharides such as alginate, Psl, and Pel form the structural matrix of biofilms, promoting cell aggregation and protection against stressors.^[27] These EPS enable Pseudomonas to colonize surfaces and withstand desiccation or antimicrobial agents in diverse habitats.^[28] In marine organisms, mucilage is prominently produced during algal blooms, often leading to large-scale aggregations. Dinoflagellates, such as those in the 2021 Marmara Sea "sea snot" event, secrete copious EPS that form gelatinous matrices, exacerbated by warm temperatures and nutrient enrichment.^[29] This phenomenon, observed across the Mediterranean, involves species like Gonyaulax fragilis contributing to sticky, floating veils that disrupt ecosystems.^[30] Marine mucilage typically consists of EPS rich in polysaccharides, often featuring sulfate groups that enhance stickiness and ion binding. These sulfated EPS promote plankton aggregation, facilitating particle sinking and carbon export in oceanic food webs.^[31]^[32] In marine contexts, this composition contrasts with terrestrial forms by incorporating uronic acids and sulfates for osmotic regulation.^[33] Ecological crises involving mucilage have intensified in regions like the Adriatic Sea since the 2000s, linked to eutrophication from nutrient runoff. Recurrent events, such as those in 1999–2002 and 2024, feature massive EPS blooms triggered by high freshwater inputs, stratification, and phosphorus excess, altering nutrient ratios and hypoxia.^[34]^[35] These incidents, driven by anthropogenic pressures, have increased in frequency, impacting biodiversity and fisheries.^[36]

Production and Extraction

Biosynthesis

Mucilage biosynthesis in plants primarily occurs through nucleotide sugar-dependent pathways in the Golgi apparatus, where activated sugars such as UDP-glucose (UDP-Glc) and GDP-mannose serve as precursors for polysaccharide assembly. For instance, galactomannans, a common mucilage component, are synthesized from GDP-mannose via mannan synthase enzymes, which polymerize mannose units before side-chain galactosylation using UDP-galactose.^[37]^[38] These processes involve glycosyltransferases that elongate the polysaccharide chains, followed by secretion into the cell wall or extracellular space through Golgi-derived vesicles.^[39] Recent studies (as of 2024) utilize advanced analytical techniques to further elucidate mucilage polysaccharide microstructure and genetic regulation in seed coats, enhancing understanding of biosynthesis.^[40] Genetic regulation of mucilage production in plants, particularly in model species like Arabidopsis thaliana, involves specific genes that coordinate polysaccharide synthesis and attachment. The SOS5 gene encodes a fasciclin-like arabinogalactan protein essential for root mucilage adherence and structure, interacting with cellulose microfibrils via the FEI receptor-like kinases to facilitate proper cellulose biosynthesis by CELLULOSE SYNTHASE 5 (CESA5).^[41]^[42] Mutations in SOS5 disrupt these interactions, leading to altered mucilage composition and reduced adherence to seed coats or root surfaces.^[43] In microorganisms, mucilage-like exopolysaccharides (EPS) are biosynthesized via distinct pathways tailored to bacterial or algal physiology. Bacteria employ the Wzx/Wzy-dependent pathway for EPS production, where repeating units are assembled on lipid carriers at the cytoplasmic membrane by initiating glycosyltransferases, then flipped across the membrane by Wzx flippase and polymerized by Wzy polymerase before export.^[44]^[45] This mechanism is prevalent in Gram-negative bacteria producing capsular or slime-layer mucilages. In algae, particularly brown algae, alginate—a key mucilage polysaccharide—is initially synthesized as polymannuronan from GDP-mannuronic acid, followed by post-polymerization modification via mannuronan C-5-epimerases that convert mannuronic acid residues to guluronic acid, influencing gelation properties.^[46]^[47] Environmental stresses such as drought or wounding upregulate mucilage biosynthesis in plants through abscisic acid (ABA) signaling, which activates transcription factors to enhance nucleotide sugar precursor production and glycosyltransferase expression. ABA accumulation under drought triggers stomatal closure and osmoprotectant synthesis, including mucilage polysaccharides that aid water retention in roots and seeds.^[48] In Arabidopsis, ABA-responsive pathways intersect with mucilage regulation, as seen in mutants with altered phospholipase C activity showing enhanced drought tolerance linked to modified seed mucilage release.^[49] Wounding similarly induces ABA-mediated gene expression to promote localized mucilage deposition for tissue protection.^[50]

Extraction Methods

Mucilage extraction from plant sources typically begins with traditional methods such as water maceration or hot water extraction, which rely on the polysaccharide's hydrophilic nature to facilitate release from tissues. In water maceration, raw materials like chia seeds are soaked in distilled water at room temperature for several hours with occasional agitation, yielding approximately 5-7% mucilage by weight after filtration and precipitation. Hot extraction involves immersing the material in water at 60-80°C for 1-2 hours under continuous stirring, as commonly applied to seeds or leaves; for instance, this method extracts about 6.4% yield from Salvia hispanica seeds, though higher temperatures can lead to partial degradation of the polymer structure.^[51]^[2] Modern techniques enhance efficiency and yield by disrupting cell walls more effectively, reducing extraction time and solvent use. Microwave-assisted extraction employs 300-400 W power for 120-180 seconds, achieving yields up to 8.3% from chia seeds while preserving structural integrity better than thermal methods. Ultrasonic extraction, using low-frequency waves (e.g., 22 kHz) for 20-30 minutes, boosts yields significantly, such as 6.75% from flaxseed or 9-10% from okra pods at 55-65°C, due to cavitation effects that accelerate mass transfer. Enzymatic hydrolysis with enzymes like rhamnase or arabinase further improves purity by selectively breaking down associated impurities, enabling yields approaching 30% w/w in optimized cases like psyllium husk, though it requires precise control to avoid over-degradation.^[2]^[52]^[53] Recent advances (as of 2024-2025) include green methods like deep eutectic solvents and synergistic ultrasound-microwave extractions, which offer higher efficiency, sustainability, and yields up to 24% for certain sources.^[13] Following extraction, purification steps are essential to isolate high-quality mucilage, typically involving precipitation with ethanol (adding 2-3 volumes to the filtrate) to separate the gel from water-soluble contaminants, followed by dialysis against distilled water to remove salts, proteins, and low-molecular-weight impurities. These processes yield a purified product with reduced ash content and improved solubility, but challenges persist, including protein contamination that can alter viscosity and microbial growth risks from residual moisture levels around 10%, necessitating immediate drying or lyophilization post-purification.^[2]^[54] At industrial scales, extraction from sources like okra and aloe vera is optimized for specific purity grades, balancing yield with regulatory requirements for food or pharmaceutical use. For okra, ultrasound-assisted hot extraction at 55-65°C for 20-30 minutes produces 9-10% yields suitable for food-grade applications, with additional centrifugation and ethanol precipitation ensuring low microbial loads; pharmaceutical variants incorporate extended dialysis for higher purity, removing over 90% of proteins. Aloe vera mucilage is industrially obtained via mechanical fileting of leaves, followed by homogenization and centrifugation of the gel, yielding up to 86% gel mass (with mucilage comprising 70-80% thereof), and hot water extraction maximizes output at scale while stabilizers prevent enzymatic browning during processing for both food and pharma grades.^[53]^[55]^[56]

Applications

Traditional and Culinary Uses

Mucilage has been employed in traditional remedies since ancient times, particularly for its soothing and protective qualities on irritated tissues. In ancient Egypt, aloe vera mucilage was applied topically as a paste or poultice to treat skin diseases, burns, and wounds, as documented in the Ebers Papyrus dating back to around 1550 BCE.^[57] Similarly, in medieval Europe, linseed (flaxseed) mucilage was used in hot poultices to alleviate inflammation, pain, and promote suppuration in conditions such as boils and abscesses, drawing from herbal traditions like those of Culpeper.^[58] In culinary applications, mucilage serves as a natural thickening agent due to its viscous, gel-forming properties when hydrated. Okra pods, rich in mucilage, are a staple in Southern U.S. gumbos, where prolonged cooking releases the gel to create a characteristic silky texture without additional starches.^[59] Chia seeds, another mucilage source, are soaked in milk or plant-based alternatives to form puddings, where the gel provides a creamy consistency and acts as a binder in no-bake desserts.^[60] Nutritionally, mucilage functions as soluble dietary fiber that absorbs water in the gut, promoting regular bowel movements, easing digestion, and supporting laxative effects by softening stool and increasing bulk.^[61] Cultural practices highlight mucilage's role in regional medicine and cuisine. In Ayurvedic traditions, psyllium husk mucilage (known as isabgol) is consumed as a bulk-forming laxative to relieve constipation, piles, and digestive disorders by forming a soothing gel that lubricates the intestines.^[62] In Middle Eastern confectionery, tragacanth gum mucilage is incorporated into sweets like halva to enhance chewiness, stability, and texture, often as a binder in sugar-based treats.^[63] Mucilages from sources like psyllium and plant gums are generally recognized as safe (GRAS) by the FDA when used as dietary fibers in food, with established health claims for digestive benefits at intakes of 7 grams per day for psyllium.^[64] However, excessive high-fiber mucilage consumption can lead to bloating or choking risks if not taken with sufficient water, so dosages should not exceed recommended levels to avoid gastrointestinal discomfort.^[65]

Industrial and Pharmaceutical Applications

Mucilage, particularly from plant sources like guar (Cyamopsis tetragonoloba) and flaxseed (Linum usitatissimum), serves as a natural binder in the ceramics and paper industries, enhancing slurry flow, suspension stability, and product cohesion while reducing the need for synthetic additives.^[66] In paper manufacturing, guar gum mucilage improves ink retention, water resistance, and surface smoothness during coating processes, contributing to higher-quality end products.^[67] Similarly, in ceramics, it acts as a suspending agent to prevent particle settling and ensure uniform green body formation during molding.^[68] In the textile sector, chia seed mucilage functions in nanofibers for various applications. For cosmetics, plant mucilages like those from chia seeds (Salvia hispanica) and Basella alba are incorporated into moisturizers and emulsifiers, leveraging their hydrating and stabilizing properties to create natural formulations that rival synthetic polymers like carbomers in efficacy and biocompatibility.^[2] These applications highlight mucilage's advantages as a low-cost, biodegradable alternative to petroleum-based thickeners, promoting sustainable manufacturing practices.^[7] Pharmaceutically, mucilages are valued as excipients in tablet formulations, where they enable sustained drug release by forming viscous matrices that control dissolution rates; for instance, Grewia asiatica fruit mucilage achieves over 80% drug release within 30 minutes in controlled studies.^[2] In wound dressings, alginate mucilage derived from brown algae (e.g., Laminaria species) forms biocompatible hydrogels that absorb exudate, maintain a moist healing environment, and promote tissue regeneration, with clinical evidence supporting reduced healing times compared to traditional gauze.^[69] Basil seed (Ocimum basilicum) mucilage, often combined with nanoparticles like ZnO, further enhances antimicrobial activity in such dressings.^[70] Mucilage-based hydrogels are integral to advanced drug delivery systems, encapsulating therapeutics for targeted release; basil seed mucilage conjugated with Fe₃O₄ nanoparticles, for example, demonstrates pH-responsive delivery of antibiotics like cephalexin.^[2] Emerging applications include biodegradable films for packaging, where okra (Abelmoschus esculentus) mucilage composites provide barrier properties against oxygen and moisture, offering an eco-friendly substitute for plastic films with demonstrated tensile strengths suitable for commercial use.^[71] In cancer therapy, post-2010 innovations such as mucilage nanoparticles loaded with paclitaxel exhibit high drug loading (above 75%) and tumor-targeted delivery, as evidenced in preclinical models, underscoring mucilage's biocompatibility and potential to minimize side effects of synthetic nanocarriers.^[2] These developments position mucilage as a versatile, cost-effective platform for pharmaceutical innovation.^[72]

Ecological and Biological Roles

Roles in Plant Physiology

Mucilage plays a pivotal role in seed germination by promoting hydration and adhesion to the soil, thereby enhancing the establishment of seedlings. Upon contact with water, the hydrophilic polysaccharides in seed coat mucilage rapidly expand to form a gel-like envelope that retains moisture around the embryo, preventing desiccation and facilitating imbibition, particularly under abiotic stresses like drought. For instance, in species such as Lepidium perfoliatum, mucilaginous seeds exhibit faster germination rates, completing the process in 1–3 days compared to over 3 days for demucilaged seeds, due to improved water uptake and energy provision from mucilage polysaccharides.^[3] This hydration mechanism is especially critical in arid environments, where mucilage maintains seed viability in soil seed banks by regulating dormancy and initiating DNA repair processes.^[73] The adhesive properties of mucilage further support germination by anchoring seeds to soil particles, increasing contact area and stability for radicle protrusion. In temperate grassland species, adherent mucilage types, observed in 12 of 43 mucilage-producing species (about 28%), hold seeds in place against water flow or wind, promoting site-specific establishment without significantly altering overall germination timing across moisture gradients.^[19] Studies on myxospermous seeds, such as those of Plantago species, demonstrate that this adhesion not only aids physical positioning but also lubricates the emerging radicle, easing penetration into compact soils and boosting early seedling vigor.^[74] In root physiology, mucilage exudates from root cap and border cells function primarily as a lubricant, reducing frictional resistance during soil penetration and enabling efficient root elongation. In maize (Zea mays), growing roots with the slimy mucilage layer experience 50–100% of the penetration resistance compared to pushed roots, allowing tips to navigate dense or compacted soils with minimal mechanical impedance.^[75] This lubrication is complemented by mucilage's role as a selective microbial barrier in the rhizosphere, where its gel matrix creates a moist, nutrient-rich microenvironment that fosters beneficial bacteria (e.g., nitrogen-fixers like Rhizobium spp.) while limiting pathogen access through physical entrapment and antimicrobial components such as extracellular DNA and histone H4.^[1]^[76] In maize roots from drought-prone regions, higher mucilage production correlates with enhanced rhizosphere microbial diversity, further stabilizing root-soil interfaces.^[77] Mucilage is integral to plant stress adaptation, particularly in mitigating drought through superior water retention and hydraulic facilitation. Its hygroscopic nature allows absorption of 27–589 times its dry weight in water, extending the time roots can extract soil moisture and delaying stomatal closure under drying conditions; in maize, genotypes from high-vapor-pressure-deficit climates exude up to 135% more mucilage, improving uptake and shifting plants toward anisohydric behavior for sustained photosynthesis.^[1]^[77] In succulent plants like cacti (Opuntia spp.), mucilage stores substantial water reserves, contributing to high retention capacity and enabling survival in arid habitats by buffering against dehydration and oxidative stress.^[78] Additionally, the slimy coating provides pathogen defense by forming a physical barrier that impedes fungal and bacterial invasion at vulnerable sites like root tips and seeds, as evidenced by reduced infection rates in mucilage-producing tissues.^[79] During plant development, mucilage supports key processes in reproductive structures, including floral nectaries and fruit tissues, to optimize pollination and dispersal. In nectaries of species like Hibiscus rosa-sinensis, mucilage regulates water economy and nectar viscosity, ensuring stable secretion and pollinator attraction while preventing excessive evaporation.^[80] In fruits, mucilage facilitates seed dispersal by creating adhesive coatings that promote epizoochory or endozoochory; for example, in species such as Plantago (myxospermous seeds), the gelatinous matrix aids passage through digestive tracts, enhancing long-distance propagation while protecting embryos from abrasion.^[81] These developmental roles underscore mucilage's contribution to reproductive success, with production often localized in specialized cells like those in seed coats or pericarp tissues.^[82]

Environmental and Ecological Implications

Root mucilage plays a crucial role in soil stabilization by binding soil particles, thereby enhancing aggregate stability and reducing erosion rates in various ecosystems. This binding effect increases soil resistance to shear stress and mechanical impedance, particularly in grasslands and arid regions where root exudates like mucilage act as natural adhesives.^[83]^[21] Additionally, plant root exudates, including mucilage, contribute to carbon sequestration by supplying organic carbon to the soil, which supports microbial activity and long-term storage in soil organic matter. These exudates form a significant portion of rhizodeposition, promoting belowground carbon accumulation and potentially mitigating atmospheric CO2 levels through enhanced soil carbon stocks.^[84]^[85] In marine environments, excessive mucilage production by phytoplankton and other organisms can lead to harmful blooms, as observed in the 2021 event along the Turkish coast in the Sea of Marmara, where dense mucilage layers caused widespread fish kills, shellfish mortality, and oxygen depletion, severely disrupting local ecosystems. A similar event occurred in winter 2025, exacerbating oxygen depletion and disrupting ecosystems amid continued climate pressures.^[86] These blooms, exacerbated by pollution and warming waters, smother benthic habitats and reduce light penetration, leading to mass deaths of marine invertebrates and fish.^[87] Climate change influences mucilage dynamics, with warming temperatures and drought conditions often increasing production in plants as an adaptive response to water stress, enhancing root-soil interactions in dry soils. In wetland ecosystems, mucilage from aquatic and emergent plants aids natural filtration processes by adsorbing pollutants and improving water clarity, supporting overall habitat health.^[88]^[89] To address sustainability concerns in sourcing mucilage, alternatives like xanthan gum from microbial sources or mucilages from underutilized plants such as flaxseed and chia are being explored to reduce pressure on traditional sources while maintaining ecological balance.^[90]^[2]

References

[1]
Biogels in Soils: Plant Mucilage as a Biofilm Matrix That Shapes the ...
Mucilage is a gelatinous high-molecular-weight substance produced by almost all plants, serving numerous functions for plant and soil.
[2]
A Comprehensive Review on Plant-Derived Mucilage - NIH
The Mucilage is a water-soluble edible adhesive material that constitutes carbohydrates and uranic acids units present in different parts of plants including ...
[3]
The Renaissance of Plant Mucilage in Health Promotion and ...
Plant mucilage is a renewable and cost-effective source of plant-based compounds that are biologically active, biodegradable, biocompatible, nontoxic, ...Missing: definition | Show results with:definition
[4]
Unveiling the potential of linseed mucilage, its health benefits, and ...
The functional properties, such as good water-holding, emulsifying, fat-replacing, textural, stabilizing, and interfacial properties, of linseed mucilage make ...
[5]
Assessment of the application of cladode cactus mucilage ...
Assessment of the application of cladode cactus mucilage flocculants for hot chemical degreasing electroplating wastewater treatment and reuse: process ...<|control11|><|separator|>
[6]
The Renaissance of Plant Mucilage in Health Promotion and ... - MDPI
These criteria are met by plant mucilage—a polysaccharide hydrocolloid with unique properties. Mucilage can occur directly as a jelly-like structure in the ...
[7]
Mucilage - Etymology, Origin & Meaning
Late 14c. late comes from Old French mucilage and Late Latin mucilago, meaning a viscous, adhesive substance originally referring to musty or moldy juice.
[8]
Mucilage - an overview | ScienceDirect Topics
Plant mucilages differ from pectin in that they do not form gels. Mucilages are generally heteropolysaccharides, with varying uronic acid content. They are ...
[9]
https://www.sciencedirect.com/topics/engineering/mucilage
[10]
A review on recent advances of plant mucilages and their ...
Plant mucilages have been used for many applications as stabilizers, emulsifiers, thickening or gelling agents, viscosity modifiers, encapsulating agents ...
[11]
Mucilage polysaccharide as a plant secretion: Potential trends in ...
Regarding the chemical composition, mucilage is formed mainly of a complex of polymeric polysaccharides of high molecular weight joined with organic acids.
[12]
Advances in seed mucilage: Chemical characterization, functional ...
Seed mucilage primarily comprises hydrocolloids, mainly polysaccharides such as pectins and hemicelluloses, along with neutral sugars and uronic acid residues.
[13]
Structural analysis and characterization of a mucopolysaccharide ...
Sugar composition and molecular properties of purified samples were analyzed using high-performance liquid (HPLC), anion exchange (HPAEC-) and size exclusion ( ...
[14]
Mucilage - an overview | ScienceDirect Topics
Consequently, when a mucilage is mixed with water it swells to many times its original volume as it absorbs water.
[15]
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mucilage
[16]
https://www.scielo.br/j/bjft/a/HT8TdvcWRmMxKTttT4fzLvc/
[17]
Seed mucilage in temperate grassland species is unrelated to ... - NIH
Feb 21, 2024 · Surveys of plant communities in arid and semi‐environments indicate that 10%–32% of species produce seed mucilage (Table 1 and references ...
[18]
Proteomics Analysis Reveals the Underlying Factors of Mucilage ...
Feb 7, 2024 · Proteomics analysis reveals the underlying factors of mucilage disappearance in Brasenia schreberi and its influence on nutrient accumulation.
[19]
Contribution of Root Cap Mucilage and Presence of an Intact ... - NIH
Thus, the contribution of mucilage to the reduction in soil resistance to maize root growth may become much smaller under drier condition. Plant root mucilage ...
[20]
a novel component of the mucilage-secretory apparatus in Malvaceae
Jan 10, 2025 · Mucilage-secreting cells in P. polymorpha are interconnected idioblasts and represent a novel component of the mucilage-secretory apparatus in Malvaceae.
[21]
Secretory structures of the Adesmia clade (Leguminosae)
All genera of the Adesmia clade shared the presence of secretory, mucilaginous idioblasts in the epidermis of their leaflets.
[22]
Contribution of frustules and mucilage trails to the mobility of diatom ...
May 14, 2019 · This research hammers out more precise information about mucilage trails which would be useful in terms of diatom motility and biofouling prevention.
[23]
Gliding motility of the diatom Craspedostauros australis coincides ...
Raphid diatoms are one of the few eukaryotes capable of gliding motility, which is remarkably fast and allows for quasi-instantaneous directional reversals.
[24]
Characterization of the Adhesive Mucilages Secreted by Live ...
A second adhesive mucilage consisted of strands secreted at the raphe, a distinct slit in the silica wall involved in cell-substratum attachment and motility.
[25]
Role of Exopolysaccharides in Pseudomonas aeruginosa Biofilm ...
At least three exopolysaccharides (alginate, Psl, and Pel) contribute to the formation of biofilms in this organism. Here mutants deficient in the production of ...Missing: mucilage | Show results with:mucilage
[26]
Plant Growth-Promoting Bacteria (PGPB) with Biofilm-Forming Ability
Jan 13, 2023 · One of the best-studied models for biofilm formation is Pseudomonas aeruginosa, which produces at least three different exopolysaccharides, ...
[27]
https://pmc.ncbi.nlm.nih.gov/articles/PMC3147449/
[28]
The early stage of mucilage formation in the Marmara Sea during ...
Sep 30, 2021 · (2021) Toxic marine microalgae and noxious blooms in the Mediterranean Sea: A contribution to the Global HAB Status Report. Harmful Algae ...
[29]
Benthic mucilage blooms threaten coralligenous reefs - ScienceDirect
Evident signs of necrosis have been described in many benthic coralligenous taxa subject to mucilage overgrowth, such as sponges, scleractinians, encrusting ...Missing: tunicates | Show results with:tunicates
[30]
Marine Natural Products from Tunicates and Their Associated ...
Microbes associated with tunicates have been found to produce potential metabolites showing antimicrobial and anticancer activities (Figure 1, Figure 2 and ...
[31]
Bacteria contribute exopolysaccharides to an algal-bacterial joint ...
Apr 1, 2024 · EPS is a key ECM component in most biofilms, and is often central in the formation of multidimensional structures that promote the colonization ...
[32]
Microbial Extracellular Polymeric Substances (EPSs) in Ocean ...
EPS: A Microbial Adaptation for Aggregation and Attachment Extracellular polymeric substance are purposefully produced by microbes: (a) as secretions of ...
[33]
Exopolysaccharides from Marine Microbes: Source, Structure and ...
These EPS usually have a complex monosaccharide composition with uronic acid and sulfate groups, with various biological activities such as antioxidant ...Missing: mucilage | Show results with:mucilage
[34]
Changes in nutrient concentrations and ratios during mucilage ...
Changes in nutrient concentrations and ratios during mucilage events in the period 1999–2002 ... Adriatic Sea: analysis of the 1977 event in comparison to ...
[35]
Extraordinary mucilage event in the northern Adriatic in 2024—a ...
Extreme mucilage event occurred in spring and summer 2024 in the northern Adriatic. Large freshwater load, increased temperature and ocean stratification were ...
[36]
Stratigraphic unmixing reveals repeated hypoxia events over the ...
Apr 1, 2017 · The ecosystem of the northern Adriatic Sea was affected by eutrophication, algal blooms, mucilage blooms, and hypoxia during the second half of ...
[37]
Modern mannan: a hemicellulose's journey - Wiley Online Library
Mar 14, 2022 · Hemicelluloses are synthesized in the Golgi apparatus using activated sugar donors, which are typically linked to uridine diphosphate (UDP) or ...
[38]
MUCILAGE-RELATED10 Produces Galactoglucomannan That ...
Our detailed analysis of the muci10 mutants demonstrates that mucilage contains highly branched galactoglucomannan (GGM) rather than unbranched glucomannan.
[39]
Biosynthesis and Transport of Nucleotide Sugars for Plant ... - NIH
Nov 12, 2021 · The conversion of UDP-Glc to UDP-Rha in bacteria requires three enzymatic sequences: dehydratase, isomerase, and reductase, while in plants, it ...
[40]
The FEI2-SOS5 pathway and CELLULOSE SYNTHASE 5 are ...
The FEI1/FEI2 receptor-like kinases and the SOS5 extracellular GPI-anchored protein were previously shown to act on a pathway regulating cellulose biosynthesis ...
[41]
SALT-OVERLY SENSITIVE5 Mediates Arabidopsis Seed Coat ...
SOS5 has been suggested to mediate adherence by influencing cellulose biosynthesis. We, therefore, investigated the relationship between SOS5 and CESA5. cesa5-1 ...
[42]
Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5 ...
Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5) Mediates Root Growth and Seed Mucilage Adherence via a Cell Wall Receptor-Like Kinase (FEI1/ ...
[43]
Bacterial exopolysaccharides: biosynthesis pathways and ...
The second pathway of bacterial exopolysaccharide biosynthesis is the ABC transporter dependent pathway which is mainly present in capsular polysaccharide (CPS) ...
[44]
Exopolysaccharides Producing Bacteria: A Review - PMC - NIH
There are four general mechanisms for EPS biosynthesis in bacterial cells; they are the Wzx/Wzy-dependent pathway, the ABC transporter-dependent pathway, the ...
[45]
Advances in alginate biosynthesis: regulation and production in ...
Alginate epimerases have been shown to produce alginates with high G contents and to modify the monomeric composition of alginates extracted from different ...
[46]
Mannuronate C-5 epimerases and their use in alginate modification
Mar 6, 2023 · Following biosynthesis, alginate C-5 epimerases convert M to G residues at the polymer level. Alginate epimerases have been found in brown algae ...
[47]
Mechanisms of Abscisic Acid-Mediated Drought Stress Responses ...
Abscisic acid (ABA) is a premier signal for plants to respond to drought and plays a critical role in plant growth and development.
[48]
Role for Arabidopsis PLC7 in Stomatal Movement, Seed Mucilage ...
These include a defect in seed mucilage, enhanced leaf serration, and an increased tolerance to drought. Overexpression of PLC7 enhanced drought tolerance.
[49]
The JA-to-ABA signaling relay promotes lignin deposition for wound ...
Oct 7, 2024 · The induced JA signaling promotes ABA biosynthesis to maintain the expression of RAP2.6, a key factor for sustained lignin biosynthesis and ...
[50]
https://pubmed.ncbi.nlm.nih.gov/39262116/
[51]
https://doi.org/10.1007/s13197-017-2954-4
[52]
Okra (Abelmoschus esculentus L.) as a Potential Functional Food ...
Aug 16, 2021 · Ultrasound-assisted extraction showed excellent extraction yields (9–10%) at temperatures between 55 and 65 °C for 20 to 30 min [33]. 6.
[53]
https://pmc.ncbi.nlm.nih.gov/articles/PMC8399980/
[54]
Extraction and Physicochemical Characterization of Dried Powder ...
May 22, 2021 · In this study, powdered mucilage was obtained from cladodes of Opuntia ficus-indica (OFI) and aloe vera (AV) leaves, and their molecular, morphological, and ...
[55]
Extraction, Purification, Structural Characteristics, Biological ... - NIH
Briefly, the water exaction method includes cleaning, homogenization, separation, and centrifugation of Aloe vera.
[56]
ALOE VERA: A SHORT REVIEW - PMC
History. Aloe vera has been used for medicinal purposes in several cultures for millennia: Greece, Egypt, India, Mexico, Japan and China.
[57]
A Modern Herbal | Flax - Botanical.com
... linseed in making poultices, as they contain much mucilage, though not so much oil. Linseed has occasionally been employed as human food - we hear of the ...Missing: European | Show results with:European
[58]
Okra Gumbo Recipe - Chili Pepper Madness
Rating 5.0 (10) · 2 hrSep 26, 2022 · Okra is an ingredient commonly used in gumbo as a thickener due to it's mucilaginous quality, or "sliminess". This thick mucilage spreads out ...
[59]
Mucilaginous Magic: The Incredible (and Incredibly Useful ... - Saveur
May 17, 2017 · It's the same type of material found in flax and chia seeds that makes them so great for thickening raw vegan puddings and sauces. Some edible ...Missing: agent | Show results with:agent
[60]
Fiber | Linus Pauling Institute | Oregon State University
Highly viscous fibers can trap bile that is released in the small intestine in response to a meal to assist the digestion and absorption of fatty acids. The ...
[61]
Isabgol: Psyllium Husk: Uses, Remedies, Research, Side Effects
Mar 29, 2017 · It is a laxative used to treat constipation, piles, flatulence and fistula in ano. Golax powder: It is a proprietary Ayurvedic medicine.
[62]
https://www.easyayurveda.com/2017/03/29/isabgol-psyllium-husk-plantago-ovata/
[63]
Questions and Answers on Dietary Fiber - FDA
Jul 25, 2024 · Psyllium husk (as described in §101.81 (c)(2)(ii)(B)(1)); Cellulose ... Mixed plant cell wall fibers (a broad category that includes fibers like ...What are some of the actions... · What isolated or synthetic...
[64]
[PDF] GRAS Notice GRN 868 Agency Response Letter -coffee fruit extract
Mar 24, 2020 · ... GRAS panel). Based on its review, VDF's GRAS panel concluded that coffee fruit extract is safe under the conditions of its intended use ...
[65]
Guar gum: processing, properties and food applications—A Review
It is largely used in the form of guar gum powder as an additive in food, pharmaceuticals, paper, textile, explosive, oil well drilling and cosmetics industry.
[66]
Guar Gum - an overview | ScienceDirect Topics
Guar gum and its various chemical derivatives find wide applicability in various industries, such as textiles, mining, paper, ceramic, paint, cosmetic, ...
[67]
How Industrial Guar Gum Enhances Ceramic & Detergent ...
How industrial-grade guar gum improves slurry flow, binding, and suspension in ceramic and detergent production for higher efficiency and quality.
[68]
Plant-Based Gums and Mucilages Applications in Pharmacology ...
Mar 22, 2021 · Mucilage is a thick, sticky substance produced by almost all plants and some microorganisms. Gums and mucilages have certain similarities; both ...
[69]
https://pmc.ncbi.nlm.nih.gov/articles/PMC8004199/
[70]
Mucilage-Based Nanocarriers for Targeted Cancer Therapy-Design ...
Aug 1, 2025 · This review highlights the novelty of mucilage-based systems as a sustainable and multifunctional nanoplatform for cancer therapy.Missing: nanoparticles patents post- 2010
[71]
https://pmc.ncbi.nlm.nih.gov/articles/PMC8401871/
[72]
Review More than just a coating: Ecological importance, taxonomic ...
Seed germination. Seed mucilage has long been proposed to promote seed germination through attraction and retention of water surrounding the seed (Harper and ...
[73]
Seed Mucilage: Biological Functions and Potential Applications in ...
Jul 1, 2021 · Mucilage has been found to influence seed germination and seedling establishment, most often during abiotic stress, probably by maintaining seed hydration when ...
[74]
Sloughing of root cap cells decreases the frictional resistance to ...
The penetration resistance to the growing root was between 50% and 100% of that to the pushed root, indicating that the relief of friction and slower rate of ...Missing: reduces | Show results with:reduces
[75]
Root Border Cells and Mucilage Secretions of Soybean, Glycine ...
The mucilage also contains exDNA and histone H4, two components known to have a defensive function in plants and mammals [14,24]. Our findings also support the ...
[76]
Mucilage Polysaccharide Composition and Exudation in Maize From ...
Dec 8, 2020 · Mucilage likely contributes to plant resistance to water stress, and may be particularly important in water-limited environments (Ahmed et ...<|separator|>
[77]
Development and Application of Mucilage and Bioactive ...
Nov 13, 2024 · Thus, the viscosity of the mucilage should be adjusted to the application method, as less viscous solutions are preferable for spray ...<|separator|>
[78]
Natural nanofibers embedded in the seed mucilage envelope - NIH
Dec 13, 2024 · Mucilage serves several important biological functions, such as supporting seed germination, protecting seeds against pathogens and predators, ...Missing: defense slimy
[79]
The subglandular tissue of Hibiscus rosa-sinensis nectaries
Mucilage plays an important role in the regulation of water economy, which is decisive in nectar secretion. The oil cells mainly protect the sugar containing ...
[80]
The role of mucilage envelope in the endozoochory of selected plant ...
Dec 11, 2020 · The mucilage envelope plays diverse roles beyond reproduction, including creating proper (water) conditions for germination and protecting the ...Material And Methods · Results · Discussion
[81]
Uncovering the Neglected Floral Secretory Structures of ...
Apr 9, 2021 · The function of mucilage may consist of carbohydrate storage, water storage, reduction of transpiration, protection against intensive radiation ...
[82]
(PDF) Impact of roots on soil stabilization in grassland - ResearchGate
Dec 18, 2015 · Plant roots play a key role in erosion control by increasing soil resistance to shear stress. Root tensile strength data have been published ...
[83]
Contribution of roots to soil organic carbon: From growth to ...
Carbon (C) derived from roots, rhizodeposition of living roots and dead root decomposition, plays a critical role in soil organic C (SOC) sequestration.
[84]
The role of roots on carbon sequestration
Feb 10, 2023 · Plant roots provide soil organic carbon primarily in the form of root litter and the release of organic material, including exudates, dead cells ...
[85]
(PDF) Marine Mucilage in the Sea of Marmara and Its Effects on the ...
Aug 9, 2025 · We summarize our results about the devastating effect of mucilage bloom on mass deaths in the Sea of Marmara.
[86]
Soil, climate, and variety impact on quantity and quality of maize root ...
Aug 30, 2022 · This study investigated the influence of climate and soil on the exudation rate and polysaccharide composition of aerial nodal root mucilage
[87]
A comprehensive review of plant-based mucilages as promising ...
Mucilages remediate wastewater by removing trace elements and turbidity, decolorizing dyes, and treating leachate. In contrast to previous studies, the present ...
[88]
40% of world's plant species at risk of extinction - The Guardian
Sep 29, 2020 · Overharvesting of wild plants, building, invasive species, pollution and, increasingly, the climate crisis are also important causes of losses.Missing: guar | Show results with:guar
[89]
Guar Gum Alternatives: Best Substitutes for Food & Cosmetics
Aug 9, 2025 · Top Guar Gum Alternative Options · Xanthan Gum: The Leading Substitute · Carboxymethyl Cellulose (CMC) · Locust Bean Gum.Missing: mucilage | Show results with:mucilage