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SOSV

SOSV is a global firm founded in 1995 by Sean O'Sullivan, specializing in early-stage investments in startups focused on human and . The firm manages $1.5 billion in as of April 2024 and supports innovative companies through specialized startup development programs that provide pre-seed funding of up to $550,000, lab facilities, mentorship, and global supply chain access. Headquartered in , with additional offices in , , , , , , and , SOSV operates across 59 countries and employs a team of nine general partners alongside diverse staff in , , and . Its investment strategy emphasizes revolutionary technologies in sectors such as climate tech, health tech, sustainable production, and life sciences, with a portfolio that includes nearly 1,000 companies, many featuring founders or diverse leadership—32% with at least one female founder. Key programs include HAX, launched in 2012 in as the world's first hardware accelerator, which aids hard tech startups in prototyping and scaling physical products, and IndieBio, established in 2014 in and expanded to in 2020, dedicated to and life sciences ventures addressing challenges like cancer diagnostics and environmental . Between 2021 and 2024, SOSV's programs graduated 231 startups, which collectively raised $6.5 billion in follow-on funding from over 1,000 co-investors, underscoring the firm's role in fostering high-impact innovation.

Overview

Founding and Headquarters

SOSV was founded in 1995 by entrepreneur Sean O'Sullivan in , immediately following the of MapInfo Corporation, a he co-founded in 1985. This marked the beginning of SOSV as a entity dedicated to fostering in technology sectors. From its inception, SOSV functioned as a solo investment vehicle, with O'Sullivan personally funding early-stage technology investments using his own resources for over a decade. This "super angel" approach allowed for agile decision-making in supporting nascent startups, laying the groundwork for the firm's expansion into a broader operation. The firm's continue to be located in , at 174 Nassau Street. As of 2025, SOSV operates a global network of offices to facilitate its international reach, including sites in Cork, Ireland; , New York; ; Pune, India; San Francisco, California; Shenzhen, China; and Tokyo, Japan. These locations enable coordinated support for startups across key innovation hubs in , , Asia, and beyond. By , SOSV had grown to employ over 100 staff members worldwide, distributed across its offices to manage activities, operations, and founder support. This team structure underscores the firm's evolution from a one-person operation to a multinational organization.

Mission and Focus Areas

SOSV's mission is to launch founders who possess the insights, vision, and grit to build technology companies that advance human and through innovations. This objective centers on supporting entrepreneurs tackling global challenges in and , emphasizing innovations that yield long-term societal benefits rather than short-term gains. The firm's focus areas encompass deep tech sectors such as climate tech, which includes and solutions; health tech, spanning biotech and life sciences; and emerging domains like and . SOSV prioritizes pre-seed and seed-stage investments in high-risk, high-impact startups, providing early capital to ventures that require substantial technical development to reach viability. SOSV employs a unique program-based investing approach that integrates funding with hands-on development support, including access to specialized labs and tailored , to de-risk early-stage ventures and accelerate their progress. With approximately $1.5 billion in as of 2025, the firm enables around 60 first-check pre-seed investments of up to $550,000 each annually, alongside 150 deals, fostering a robust pipeline of transformative technologies.

History

Early Years (1995–2010)

SOSV was founded in 1995 by Sean O'Sullivan immediately following the of MapInfo Corporation, a geographic systems he co-founded in 1986. Initially structured as a personal "super angel" investment vehicle, SOSV operated as O'Sullivan's checkbook fund, allowing him to make opportunistic investments in early-stage technology companies without a formal team or institutional backing. This solo operation persisted for the first 12 years, emphasizing high-conviction bets on and startups during the dot-com boom and subsequent recovery. During this period, SOSV's investment activity centered on pre-seed and opportunities in U.S.-based ventures, amassing a portfolio of approximately two dozen companies by 2007. These investments yielded strong returns, validating O'Sullivan's approach and providing the foundation for future growth, though specific details on individual deals remain limited. The focus stayed on traditional software and hardware innovations rather than emerging sectors, reflecting the era's venture landscape dominated by and tools. Operationally, SOSV remained a lean, founder-led entity through the late 2000s, with no structured programs or accelerators in place. In 2007, leveraging the success of its early , the firm began transitioning to a multi-partner structure, gradually assembling a small of investment professionals to support deal sourcing and . By 2010, this modest expansion had positioned SOSV's —built through opportunistic, high-impact investments—as the groundwork for a more formalized orientation, with growing steadily but still at a relatively small scale compared to later funds.

Accelerator Era and Global Expansion (2011–2020)

In 2012, SOSV marked a strategic pivot toward structured accelerator programs by launching HAX in , , as the world's first hardware accelerator dedicated to pre-seed startups in areas like , technologies, and . This initiative, led by general partner Cyril Ebersweiler, provided up to $550,000 in funding along with access to Shenzhen's vast to accelerate prototyping and . The program quickly established SOSV as a leader in hard tech, supporting dozens of international founders annually through hands-on facilities and mentorship. By 2014, SOSV expanded its accelerator model into biotechnology with the launch of in , the first dedicated life sciences , offering similar pre-seed investments of up to $550,000 to startups addressing human and challenges through and therapeutics. Concurrently, SOSV introduced RebelBio in , , as an early extension of the IndieBio framework, fostering biotech innovation in a region with growing life sciences and providing a bridge for transatlantic collaboration. RebelBio operated until 2018, after which it was discontinued and its activities merged into the broader IndieBio program by 2020. These launches coincided with the opening of dedicated offices in (2012), (2014), and (2014), enabling SOSV to cultivate a global network of labs and talent pools while aligning investments with its mission in . SOSV's international footprint grew further through strategic partnerships, including a $25 million investment from New York State in 2018 to establish IndieBio New York, enhancing East Coast biotech capabilities with state-backed lab facilities. By the end of the decade, the firm had raised $277 million for its oversubscribed SOSV IV fund in late 2019, nearly doubling the prior fund's size and committing to back approximately 150 new deep tech startups annually, with a strong emphasis on climate solutions. This capital influx supported the acceleration of around 140 climate tech companies by early 2021, many emerging from HAX and IndieBio cohorts focused on decarbonization and sustainable supply chains. In 2020, SOSV bolstered its operational expertise by hiring Ned Desmond, former COO of TechCrunch, as senior operating partner to scale communications, marketing, and founder support across its programs. The onset of the in tested SOSV's global model, particularly disrupting hardware and biotech operations amid bottlenecks originating in , HAX's primary hub and an early epicenter. Founders faced delays in prototyping and access, prompting adaptations such as mentorship and remote coordination to sustain program momentum. Despite these hurdles, SOSV's diversified geography and program resilience enabled continued investment in resilient , underscoring the value of its international expansion in mitigating localized risks.

Recent Developments (2021–Present)

In 2021, SOSV raised a $100 million Select Opportunity Fund to expand investing in its existing companies. This initiative supported the firm's growing emphasis on scaling startups beyond pre-seed stages. In April 2024, SOSV closed its largest fund to date, Fund V, totaling $306 million, dedicated to maintaining continuity in investments focused on human and planetary health. SOSV continued its global expansion through new facility openings to accommodate program growth. In 2023, IndieBio New York debuted its 25,000-square-foot headquarters, including labs and event space, at 7 Penn Plaza in , enhancing access to East Coast biotech talent. In May 2024, HAX opened a 35,000-square-foot office in , backed by $25 million in state support over five years, to bolster hardware-focused acceleration in the U.S. The firm intensified its thematic initiatives in climate and health technologies. The 2024 edition of the SOSV Climate Tech 100 list highlighted top portfolio companies with an aggregate valuation of $11.1 billion and $3.68 billion raised collectively. Similarly, the 2024 Human Health 100 list showcased innovations where SOSV invested $99 million, underscoring 70% PhD-founded teams and $1.43 billion in total funding across the group. Looking ahead, SOSV scheduled the 2025 Robotics VC-Founder Matchup event for December 1–5, a virtual gathering connecting 500 startups with 500 investors to advance in . Performance metrics reflect SOSV's sustained impact amid market challenges. From 2021 to 2024, portfolio companies raised $6.5 billion in , with SOSV joining 579 rounds and leveraging a network of over 1,000 co-investors. As of November 2025, the firm made 16 new investments in the prior 12 months, contributing to 231 total graduates from HAX and IndieBio programs. At year-end 2024, SOSV reported record activity during the recovery, including $1 billion raised by portfolio companies—encompassing 80 seed and 40 later-stage rounds—with heightened focus on solutions. This resilience positioned the firm as the leading climate tech investor since , per PitchBook data.

Leadership and Organization

Key Founders and Executives

SOSV was founded in 1995 by Sean O'Sullivan, who serves as its Managing General Partner and has shaped its strategic direction as a pioneer in . O'Sullivan co-founded MapInfo in 1985, developing early that led to a successful IPO in 1994 and grew the company to over $200 million in annual revenue with more than 1,000 employees. Holding a BS in from and an MFA in Film Production from the , he has secured over 30 patents across technologies that have generated hundreds of billions in revenue, including coining the term "" in 1996 while at NetCentric. Under his leadership, SOSV has evolved from a solo "super angel" operation into a global firm investing in over 70 startups annually through programs like HAX and IndieBio, while providing follow-on funding to more than 200 companies. Key executives include Ned Desmond, Senior Operating Partner since 2020, who oversees communications, marketing, and operations to support portfolio growth. With a background as a foreign correspondent for Time magazine in Asia and a Silicon Valley reporter for Fortune, Desmond joined early internet startup Infoseek in 1996 and later served as COO of TechCrunch for eight years, scaling it into a leading tech media platform. His expertise at the intersection of media and startups has been instrumental in amplifying SOSV's visibility and operational efficiency. Among the general partners, Duncan Turner leads as Global Managing Director of HAX, SOSV's hard tech accelerator, having invested in over 100 companies across , , and sectors. Previously, Turner directed and strategy at for clients and holds a Master's from the Royal College of Art and , with his award-winning work exhibited at . Cyril Ebersweiler, another General Partner and co-Managing Director of HAX, brings experience from over 250 investments and serves on boards of companies like Formlabs. An entrepreneur who founded HAX in 2012, Ebersweiler advises startups such as and has been featured in outlets like and for his insights on and tech. For biotech-focused IndieBio, Po Bronson acts as Managing Director in , reconceptualizing complex life sciences challenges; a former and , he has guided the program since 2018 in supporting human and planetary innovations. Stephen Chambers, General Partner and Managing Director of IndieBio New York, contributes his PhD in and pharma entrepreneurship background to mentor early-stage biotech founders. SOSV's leadership team comprises nine General Partners and over 80 staff members, including domain experts in , design, and investment, distributed across offices in Princeton, , , Cork, , and other global locations. This structure enables hands-on support for founders, emphasizing empowerment through direct involvement in prototyping, strategy, and scaling to foster change-making ventures.

Funds and Financial Structure

SOSV manages a portfolio of funds dedicated to early-stage deep tech investments, with a total of $1.5 billion in as of April 2024. The firm's core funds include SOSV IV, a $277 million closed in December 2019 to support investments in deep tech startups through its accelerator programs. In June 2021, SOSV launched its $100 million Select Fund, marking its first dedicated growth-stage for follow-on investments in portfolio companies beyond pre-seed. Most recently, in April 2024, the firm closed SOSV V at $306 million, its largest core fund to date, emphasizing human and initiatives. The financial structure of SOSV is multi-stage but heavily weighted toward pre-seed investments, integrating dedicated program funds for its accelerators like HAX and IndieBio with separate follow-on vehicles to scaling. These program funds enable batch-based investments in cohorts of startups, providing not only but also access to facilities, , and operational . Complementing this, SOSV maintains a co-investment network exceeding 7,000 investors, facilitating syndicated deals and additional capital inflows for its portfolio companies. Approximately 60% of the $306 million SOSV V is allocated to post-pre-seed rounds, including through Series B and beyond. SOSV's allocation model emphasizes high-volume early interventions, issuing around 60 first-check pre-seed investments annually, each up to $550,000, alongside approximately 150 follow-on investments per year. This approach incorporates a strong diversity focus, with investments in over 500 women founders and one in three portfolio companies featuring at least one female founder. The program-based financial model minimizes founder burn rates by bundling equity financing with in-kind services such as laboratory access and engineering resources, allowing startups to prioritize development over immediate revenue generation.

Programs

HAX

HAX is SOSV's flagship accelerator program for pre-seed hard tech startups, launched in 2012 in , , by SOSV General Partner Cyril Ebersweiler to support early-stage ventures in industrial automation, climate tech, health tech, and . The program emphasizes hands-on engineering and commercialization support for hardware innovations, such as , hardware, and climate devices, helping founders de-risk prototypes and scale toward market readiness. Initially focused on Asia's advantages, HAX has expanded globally, with its primary facility now in —a 35,000-square-foot space opened in May 2024 that includes advanced prototyping tools like CNC machining and , backed by $25 million in support from the Economic Development Authority over five years. Additional offices in , , , and , , provide ongoing access to regional ecosystems. The program's structure centers on a six-month residency for cohorts of 10 to 15 startups, offering an initial investment of up to $550,000 in exchange for , along with dedicated labs, from a global network of experts, and connections primarily in . Participants receive intensive support to build and iterate prototypes, transitioning from concept to production-ready , with follow-on funding opportunities from SOSV's funds. This model prioritizes and technical validation, enabling founders to address complex challenges in sustainability-focused sectors like industrial decarbonization and . Since its inception, HAX has graduated 348 startups, collectively raising $2.5 billion in funding and achieving a cumulative valuation exceeding $8.6 billion, demonstrating its role in accelerating commercialization for hard tech innovations. Key outcomes include successful market entries for prototypes in and devices, with the program fostering long-term impact through its emphasis on sustainable technologies that advance a . Unique features, such as the forthcoming HAX Plasma Forge in , for advanced materials processing, further enhance its global prototyping capabilities and commitment to .

IndieBio

IndieBio, launched in 2014 in San Francisco as SOSV's pioneering life sciences accelerator, focuses on early-stage startups leveraging synthetic biology and health technologies to address global challenges in human and planetary health. The program selects promising teams from hundreds of global applicants, emphasizing innovations in areas like therapeutics, diagnostics, and bioengineered materials. In 2018, IndieBio expanded to New York City with $25 million in funding from New York State to support the region's burgeoning biotech sector, marking a strategic push to decentralize early-stage life sciences investment beyond the West Coast. The New York location fully opened its 25,000-square-foot headquarters at 7 Penn Plaza in 2023, featuring dedicated lab and office spaces designed to foster collaboration among entrepreneurs. The core of IndieBio is a four-month intensive residency that equips 10 to 15 teams per batch with $550,000 in seed investment, primarily in exchange for equity, to prototype and refine their technologies. Participants gain hands-on access to state-of-the-art wet laboratories and biosafety level 2 facilities at both San Francisco and New York sites, enabling rapid iteration on biological experiments without the need for external infrastructure. The curriculum includes tailored regulatory guidance to navigate FDA approvals and compliance hurdles, intellectual property support for patent strategies, and business training to transition scientists into CEOs capable of scaling ventures. Health-focused networks provide introductions to industry partners, investors, and alumni, enhancing post-program growth. IndieBio serves as the flagship for SOSV's , having accelerated over 270 companies that collectively represent more than $12 billion in enterprise value. Its graduates demonstrate significant impact, with 97% securing follow-on exceeding $1 million and multiple achieving status, including in cultivated meat, Perfect Day in precision fermentation dairy, and NotCo in plant-based foods. This track record underscores IndieBio's role in de-risking biotech commercialization and building a robust for life sciences .

Specialized Initiatives

SOSV's specialized initiatives extend its core accelerator programs by focusing on thematic scouting, networking events, and curated lists that highlight emerging trends in climate technology, human health, and . These efforts aim to foster sector-specific ecosystems by connecting founders, investors, and experts beyond the structured curricula of programs like HAX and IndieBio. In the climate technology domain, SOSV publishes the annual Climate Tech 100 list, which showcases top companies from its portfolio addressing environmental challenges. The edition features 100 companies with an aggregate valuation of $11.09 billion, including 30 newly added startups that demonstrate progress in areas such as decarbonization and sustainable materials. Complementing this, the SOSV Climate Tech Summit serves as a key networking platform; the fourth annual event, held virtually from October 14 to 18, , attracted 7,500 participants, including 100 founders and investors, with session replays made available in November to broaden access to discussions on climate innovation. SOSV also maintains specialized lists in human health, exemplified by the annual Human Health 100, which tracks leading portfolio companies in therapeutics, diagnostics, and related fields. For , this list reports an aggregate valuation of $6.67 billion across the companies, with SOSV having invested $99 million in them—a 3% increase from $96 million in —while the firms collectively raised $1.43 billion, up 1% year-over-year. This initiative builds on the legacy of RebelBio, SOSV's early European biotech accelerator launched in 2014, which supported 78 pre-seed startups in life sciences before merging with IndieBio in 2020 to integrate its expertise into broader global operations. To advance robotics innovation, SOSV organizes targeted matchmaking events, such as the 2025 Robotics VC-Founder Matchup scheduled for December 1 to 5. This free, virtual event facilitates online 1:1 meetings between approximately 500 startups and 500 investors, enabling speed-pitching opportunities to accelerate deal flow and collaboration in the sector.

Investments and Portfolio

Investment Approach

SOSV sources the majority of its investment opportunities through its accelerator programs, such as HAX and IndieBio, which receive open applications from founders worldwide, supplemented by referrals from its global network. The firm evaluates potential investments based on key criteria, including the grit and vision of founders, proprietary , and potential for significant impact on human health or planetary sustainability, such as in life sciences, , or decarbonization. Approximately 44% of portfolio founders hold PhDs, reflecting a emphasis on technical expertise, while the portfolio spans 79 nationalities to promote diversity. The firm invests across early stages, beginning with pre-seed first checks through its programs—typically ranging from $250,000 to $550,000 per startup, structured as SAFEs with valuation caps, discounts, and pro-rata rights for follow-on rounds—and extending to seed and Series A investments. SOSV writes around 60 such initial checks annually, alongside approximately 150 follow-on investments, prioritizing multi-founder teams with breakthrough technologies. One in three portfolio companies features at least one female founder, aligning with the firm's commitment to diversity, where roughly one-third of program investments support such teams. Beyond providing capital, SOSV's support model encompasses hands-on assistance, including access to 85,000 square feet of specialized labs and prototyping facilities, dedicated engineering and design teams, go-to-market strategy guidance, introductions to co-investors from a network exceeding 1,000 partners, and events like demo days and investor matchups. This integrated approach helps de-risk investments by tying additional funding to program milestones, such as prototype development and market validation, across a portfolio of over 900 deep tech startups as of late 2024.

Notable Companies

SOSV's portfolio features several standout companies that exemplify its focus on innovations in , biotech, and . In the and sector, Formlabs, a graduate of the HAX program, has revolutionized with accessible, high-precision desktop printers used across industries from prototyping to . Opentrons develops robotic systems for lab automation, enabling scalable, affordable workflows in and diagnostics that accelerate research and reduce costs. unSpun advances sustainable textiles through on-demand technology that minimizes waste by producing custom-fit clothing from recycled materials. In biotech and health, NotCo, an IndieBio alumnus, leverages to create plant-based alternatives to animal products, replicating flavors and textures for foods like and burgers to promote sustainable nutrition. Prolific Machines pioneers optogenetic tools for precise control of cell growth, targeting applications in , cultivated meat, and to improve efficiency and scalability. These companies highlight SOSV's role in fostering breakthroughs that address global challenges in and therapeutic development. In and , stands out as an early SOSV investment from its Chinaccelerator program, building a leading derivatives that democratized access to advanced trading tools for retail and institutional users. As of November 2025, SOSV's portfolio encompasses 957 , including 16 new investments from 2024 to 2025, demonstrating ongoing momentum in early-stage . The firm has also supported over 231 program graduates between 2021 and 2024, many of which have scaled into market leaders. Additionally, SOSV has invested in more than 500 women founders, with one in three portfolio featuring at least one female founder, underscoring its commitment to in .

Impact and Outcomes

SOSV's investments have significantly advanced deep tech innovations in human and planetary health, with its portfolio companies collectively raising over $6.5 billion in follow-on funding between 2021 and 2024, including SOSV's participation in 579 rounds and more than 200 pre-seed investments. This substantial capital influx underscores the firm's role in scaling early-stage startups, particularly through its accelerator programs like HAX and IndieBio, which have supported breakthroughs in areas such as biomanufacturing, climate mitigation, and hardware automation. For instance, in the climate tech sector, SOSV's portfolio achieved a valuation of nearly $6 billion as of 2021, with companies securing $2 billion in additional funding to drive sustainable technologies like methane capture and renewable materials. The firm's emphasis on has amplified its societal impact, having backed 500 women s and ensuring that one in three companies includes at least one , with approximately one dollar in every three invested supporting such diverse-led ventures. This approach not only fosters inclusive but also correlates with stronger metrics, as evidenced by SOSV's recognition in the 2025 Time/ ranking of America's top firms, where it excelled in exit volume, efficiency, and benchmarked returns. In 2024 alone, companies raised $1 billion in fresh capital across 80 seed rounds and 40 later-stage investments, highlighting sustained momentum despite market challenges. Outcomes from SOSV's portfolio include 66 documented exits, demonstrating a track record of successful and returns for investors. Notable examples feature high-profile companies like Formlabs, a leader in that has revolutionized accessible ; Opentrons, which provides automated lab systems pivotal during the response; and NotCo, an AI-driven food tech firm achieving status through plant-based innovations. These successes, alongside others such as in cultivated meat and Prellis Biologics in 3D-printed tissues, illustrate SOSV's influence in propelling from ideation to market impact, with ongoing contributions to global challenges like and environmental sustainability.

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