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Sphenoid sinus

The sphenoid sinus is a paired, air-filled paranasal sinus located within the body of the sphenoid bone, situated deep within the skull behind the upper nasal cavity and near the center of the head.^[1]^[2] These sinuses are the most posteriorly positioned among the four pairs of paranasal sinuses (frontal, ethmoidal, sphenoidal, and maxillary), communicating with the nasal cavity via openings in the sphenoethmoidal recess superior and posterior to the superior nasal concha.^[3]^[2] Anatomically, each sphenoid sinus consists of two hemisinuses separated by a thin, often asymmetric bony septum that may deviate from the midline, with the overall size and shape varying by age, sex, and ethnicity.^[1]^[2] Pneumatization, or air-filling, begins around age 2–3 years and progresses slowly, reaching full development by puberty, resulting in types such as conchal (minimal pneumatization), presellar, or sellar (extending under the pituitary fossa).^[2] The sinus walls exhibit ridges and depressions molded by adjacent structures, including the pituitary gland superiorly, optic nerves laterally, and internal carotid arteries posterolaterally.^[2] Blood supply arises primarily from pharyngeal branches of the maxillary arteries, while innervation comes from the posterior ethmoidal nerve (a branch of the ophthalmic nerve) and maxillary nerve branches.^[3] The primary functions of the sphenoid sinuses include producing mucus to trap pathogens and debris, humidifying inhaled air, and contributing to voice resonance through sound wave modification.^[1]^[3] They also help reduce the weight of the skull and may absorb minor impacts to protect cranial contents, with mucus draining into the nasopharynx via the sphenoethmoidal recess.^[1]^[2] Lymphatic drainage occurs to retropharyngeal nodes.^[2] Due to their proximity to critical neurovascular structures, the sphenoid sinuses hold significant clinical importance, particularly in endoscopic transsphenoidal surgery for accessing the pituitary gland to treat adenomas or other lesions, where anatomical variants like dehiscences in the optic canal or carotid canal must be carefully evaluated to avoid complications.^[1]^[3]^[2]

Anatomy

Location and gross structure

The sphenoid sinuses are a pair of paranasal air-filled cavities that occupy the central portion of the sphenoid bone's body.^[4] They are positioned posteriorly to the upper nasal cavity and inferior to the sella turcica, forming part of the posterior cranial base.^[4] This central location places the sinuses deep within the skull, separated by a midline intersinus septum that is often asymmetrically positioned.^[5] Each sphenoid sinus is an irregular, pneumatized space with walls consisting of thin bony plates that surround vital neurovascular structures along the midline.^[4] In adults, the typical volume of each sinus ranges from 2 to 10 mL, varying based on the extent of pneumatization, which can extend anteriorly toward the ethmoid sinuses or posteriorly toward the clivus.^[6] The anterior wall of the sinus contributes to the posterior aspect of the nasal septum, while the roof abuts the floor of the anterior cranial fossa. The ostium of each sphenoid sinus is located on the medial wall, near the superior aspect of the anterior face of the sphenoid bone, and measures approximately 2 to 4 mm in diameter.^[7] This opening drains mucus posteriorly into the sphenoethmoidal recess, a narrow passage above the superior nasal concha that communicates with the superior meatus of the nasal cavity.^[4] The precise positioning of the ostium, typically 1.5 cm superior to the posterior choanae, facilitates drainage but renders the sinus susceptible to obstruction due to its dependent orientation.^[5]

Anatomical relations

The sphenoid sinus is bordered by several vital neurovascular, endocrine, and osseous structures, underscoring the potential risks associated with its involvement in pathological processes or invasive procedures due to the proximity of these elements.^[8] The superior wall, or roof, of the sphenoid sinus forms the floor of the sella turcica and lies directly adjacent to the pituitary gland, separated by a thin layer of bone that can vary in thickness.^[8]^[9] The lateral walls are closely related to the cavernous sinuses, which house the internal carotid arteries and cranial nerves III, IV, V, and VI; the optic nerves are often closely related to the superolateral aspect of the sinus, with protrusion reported in 13-50% of cases depending on the study and population, and bony dehiscence in approximately 1.5-6.5% of cases.^[8]^[10]^[11] The internal carotid arteries often bulge into the lateral walls, with protrusion reported in 20-40% of cases, and dehiscence (absence of overlying bone) in 0.4-8% of cases.^[12]^[10]^[11] The anterior wall abuts the posterior ethmoid air cells and features the sphenoid ostium, a key drainage pathway opening into the sphenoethmoidal recess.^[9]^[8] The posterior wall adjoins the basilar part of the occipital bone and is in close proximity to the brainstem, with minimal intervening bone in some variants.^[8] Bony dehiscences or extreme thinning of the sinus walls, which expose adjacent neurovascular structures, occur with varying prevalence across populations and specific sites—ranging from 4-8% for the internal carotid artery and optic nerve to 10-30% for broader lateral wall exposures—heightening the risk of complications such as vascular injury or neural compression in inflammatory or expansive conditions.^[12]^[13]^[14]

Innervation and vascular supply

The mucosa of the sphenoid sinus receives sensory innervation primarily from the posterior ethmoidal nerve, a branch of the nasociliary nerve within the ophthalmic division (V1) of the trigeminal nerve, which supplies the posterior aspect of the sinus.^[2] Additionally, sensory fibers from the pharyngeal branch of the maxillary nerve (V2 division of the trigeminal nerve) innervate the anterolateral and inferior regions of the sphenoid sinus mucosa.^[15] Autonomic innervation to the sphenoid sinus involves both sympathetic and parasympathetic components. Sympathetic fibers arise from the superior cervical ganglion and travel via the carotid plexus along arterial branches to regulate vasoconstriction in the sinus vasculature and mucosa.^[16] Parasympathetic innervation originates from the pterygopalatine ganglion, providing secretomotor fibers that stimulate glandular secretion and vasodilation in the sinus lining.^[17] Arterial supply to the sphenoid sinus is derived from the posterior ethmoidal artery, a branch of the ophthalmic artery, which enters through the posterior ethmoidal foramina to vascularize the superior and posterior walls.^[18] The sphenopalatine artery, arising from the maxillary artery, contributes additional supply via its posterior lateral nasal branches to the anterior and lateral aspects of the sinus.^[2] Venous drainage from the sphenoid sinus occurs through the ethmoidal veins, which communicate with the superior ophthalmic vein, ultimately emptying into the cavernous sinus or the pterygoid venous plexus.^[2] This direct venous connection to the cavernous sinus increases the risk of septic thrombosis propagation from sphenoid sinus infections, potentially leading to cavernous sinus thrombosis.^[19] Lymphatic drainage of the sphenoid sinus follows afferent vessels that converge into the retropharyngeal lymph nodes, facilitating immune surveillance and fluid clearance from the sinus mucosa.^[17]

Anatomical variations

The sphenoid sinus exhibits considerable anatomical variation in its degree of pneumatization, which is classified into several types based on the extent of aeration relative to the sella turcica. The conchal type, characterized by minimal or no pneumatization anterior to the sella, is the least common, occurring in less than 10% of cases. The presellar type involves pneumatization that extends up to but not below the sella turcica, with a prevalence of approximately 25%. The most frequent configuration is the sellar type, seen in 60-70% of individuals, where pneumatization fully extends below the floor of the sella turcica, often creating a prominent sellar bulge visible on imaging.^[10]^[20]^[21] Asymmetry in sphenoid sinus pneumatization between the left and right sides is observed in 20-30% of cases, typically with one sinus demonstrating greater aeration than the other, which can complicate endoscopic access during surgical procedures. This bilateral discrepancy often correlates with deviations in the intersinus septum and may influence the proximity of adjacent neurovascular structures.^[22] A notable variant is the Onodi cell, also known as the sphenoethmoidal air cell, which represents a lateral extension of the posterior ethmoid air cells into the sphenoid sinus region, with a prevalence ranging from 10-25%. This variation is clinically significant due to its close association with the optic nerve and internal carotid artery, increasing the risk of injury during transsphenoidal surgery or sinus procedures.^[23]^[24] The intersinus septum of the sphenoid sinus frequently shows deviations, rendering it asymmetric and often inserting preferentially on one side of the sphenoid body rather than remaining midline. Such deviations contribute to unequal sinus volumes and are present in the majority of cases, with complete midline septa being rare. These variations can alter the anatomical relations to surrounding structures, such as shifting the position of the internal carotid artery protuberance.^[25]^[26] Prevalence of pneumatization types also differs by ethnicity, with Asian populations showing a higher incidence of the presellar type compared to Caucasians, potentially due to genetic influences on sinus development. For instance, studies in Chinese cohorts report presellar pneumatization in up to 30-40% of cases, versus lower rates in Western groups.^[27]^[28]

Development and physiology

Embryonic and postnatal development

The sphenoid sinus originates embryonically through an evagination of the nasopharyngeal ectoderm, forming a small pouch that invaginates into the posterior aspect of the cartilaginous nasal capsule and the primordium of the sphenoid bone around the 10th week of gestation.^[4] This initial development occurs during the third month of fetal life, establishing the foundational epithelial lining derived from the upper respiratory tract ectoderm.^[29] By the third to fourth month of gestation, pneumatization begins as a limited evagination, creating a microscopic cavity within the presphenoid cartilage that remains rudimentary and non-aerated throughout the remainder of fetal development.^[30] Postnatally, pneumatization of the sphenoid sinus initiates around 2–3 years of age, coinciding with the resorption of surrounding cartilage and ossification of the sphenoid bone.^[4] Rapid expansion occurs between ages 3 and 7, driven by the overall growth of the cranial base and expansion of the sphenoid body.^[31] This phase is followed by continued maturation, with full pneumatization typically achieved by ages 12 to 18, although some extension into adjacent structures may persist into early adulthood.^[32] During puberty, estrogen and growth hormone contribute to accelerated pneumatization, enhancing the final volumetric and structural development of the sinus. Postnatal pneumatization results in varying patterns, including conchal (minimal aeration), presellar (anterior to sella turcica), and sellar (extending under the pituitary fossa).^[2] Arrested development of the sphenoid sinus, resulting in hypoplasia, affects approximately 5% of adults.^[33] These variations in development can lead to incomplete aeration in adulthood, though most cases remain asymptomatic unless associated with other anatomical anomalies.

Functions and mucociliary clearance

The sphenoid sinus contributes to the primary functions of the paranasal sinuses, including the humidification and warming of inhaled air as it passes through the nasal cavity and sinuses, which helps prevent desiccation of the respiratory mucosa.^[17] Additionally, the air-filled cavities of the paranasal sinuses, including the sphenoid, help lighten the overall weight of the skull, facilitating cranial balance without compromising structural integrity.^[34] These functions support efficient respiration by conditioning air and reducing mechanical load on the head.^[35] In its immunological role, the sphenoid sinus mucosa produces a protective mucus layer that traps inhaled pathogens, allergens, and particulates, preventing their deeper penetration into the respiratory tract.^[36] This defense is enhanced by the secretion of secretory immunoglobulin A (sIgA) from plasma cells in the sinus submucosa, which binds to microbial antigens on the mucosal surface, neutralizing them and promoting their expulsion without triggering excessive inflammation.^[37] Goblet cells and submucosal glands in the sphenoid sinus epithelium contribute to mucus production, generating approximately 1 L of mucus daily across the paranasal sinuses to maintain this barrier.^[38] Mucociliary clearance in the sphenoid sinus relies on the pseudostratified ciliated epithelium lining its walls, where cilia beat in coordinated waves at a frequency of 10-20 Hz to propel the mucus blanket toward the sinus ostium.^[39] This movement transports trapped debris at a rate of 10-20 mm per minute within the sinus cavity, ensuring continuous renewal of the mucosal surface.^[40] The process is oriented toward the natural ostium, facilitating drainage into the sphenoethmoidal recess and ultimately the posterior nasopharynx.^[41] External factors such as sneezing provide bursts of airflow to augment clearance, while mucolytics can reduce mucus viscosity to enhance ciliary efficiency when needed.^[42] Optimal ciliary function in the sphenoid sinus is maintained by a slightly alkaline pH environment of approximately 8.0 in the sinus secretions, which supports beat frequency and prevents ciliary stasis.^[43] Sympathetic and parasympathetic innervation modulates glandular secretion and vascular tone, indirectly aiding mucus production and clearance.^[35]

Clinical significance

Infections and inflammatory conditions

The sphenoid sinus is susceptible to acute sinusitis, which often presents in isolation due to its posterior location and limited drainage pathways. This condition is uncommon compared to involvement of other paranasal sinuses, accounting for a small proportion of acute rhinosinusitis cases, and is typically caused by bacterial pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, following an initial viral upper respiratory infection that impairs mucociliary clearance.^[44] Symptoms are often subtle and nonspecific, including retro-orbital or vertex headache, fever, and facial pressure, which can mimic other neurological conditions and lead to delayed diagnosis.^[44]^[45] Chronic rhinosinusitis affecting the sphenoid sinus involves persistent inflammation lasting more than 12 weeks, frequently linked to ongoing obstruction of the sinus ostium, biofilm formation, or allergic triggers, with bacterial overgrowth playing a role in many cases.^[46]^[45] It is relatively rare as an isolated entity but contributes to the broader prevalence of chronic rhinosinusitis, which affects approximately 4-10% of adults in developed countries, though sphenoid-specific involvement is less common and often underrecognized.^[46] Common manifestations include chronic headache (reported in over 80% of cases), rhinorrhea, and occasional visual disturbances like diplopia, with nasal symptoms sometimes absent due to the sinus's inaccessibility.^[45]^[47] Fungal infections of the sphenoid sinus are particularly concerning in immunocompromised individuals, such as those with diabetes, AIDS, or undergoing chemotherapy, where they can progress rapidly. Aspergillosis, caused by Aspergillus species, is a frequent culprit in chronic invasive forms, presenting with prolonged headache, nasal congestion, and potential orbital symptoms like proptosis or diplopia.^[48] Mucormycosis, involving Mucor or Rhizopus species, is an acute, angioinvasive infection often seen in uncontrolled diabetics, characterized by necrotic tissue, facial pain, and swift invasion of adjacent structures such as the orbit or cavernous sinus, with high mortality if untreated.^[48] These infections represent about 15-20% of fungal rhinosinusitis cases overall, but sphenoid involvement heightens the risk of intracranial spread due to anatomical proximity.^[48] Diagnosis of sphenoid sinus infections and inflammatory conditions relies on a combination of clinical evaluation, imaging, and limited endoscopic assessment. Computed tomography (CT) is the gold standard, revealing mucosal thickening, complete opacification, or air-fluid levels in the sphenoid sinus, with findings like bony erosion suggesting complications; mucosal thickening greater than 4 mm is indicative of pathology.^[45]^[49] Magnetic resonance imaging (MRI) is preferred for evaluating soft tissue extension, such as orbital or intracranial involvement, providing superior contrast for inflammatory changes or abscesses.^[45]^[47] Nasal endoscopy has limited utility for the sphenoid due to its deep position but can identify mucopurulent discharge from the sphenoethmoidal recess or polyps obstructing drainage.^[45] Early suspicion is crucial, as isolated sphenoid disease often presents with headache in 64-98% of inflammatory cases.^[47] Treatment for sphenoid sinus infections varies by type and severity. Acute bacterial sinusitis is managed with supportive care (hydration, analgesics, nasal saline irrigation) and, if symptoms persist beyond 10 days or worsen, oral antibiotics such as amoxicillin-clavulanate for 5-7 days.^[44] Chronic rhinosinusitis typically involves intranasal corticosteroids, saline irrigations, and antihistamines for allergic components; long-term macrolides or oral steroids may be used, with endoscopic sinus surgery considered for refractory obstruction or complications.^[46] Fungal infections require urgent surgical debridement to remove necrotic tissue, combined with systemic antifungals—voriconazole for aspergillosis and amphotericin B plus posaconazole for mucormycosis—often with reversal of underlying immunosuppression.^[48] Complications from sphenoid sinus infections arise from their proximity to critical structures, including the cavernous sinus and meninges, facilitating spread via venous drainage or direct erosion. Cavernous sinus thrombosis, a septic complication, manifests with severe headache, periorbital edema, ophthalmoplegia, and cranial nerve deficits (most commonly involving the sixth nerve), with modern mortality rates reduced to 8-13% through prompt antibiotics and anticoagulation, though historical rates exceeded 80%.^[50]^[19] Meningitis is another severe sequela, presenting with fever, nuchal rigidity, and altered mental status, often secondary to bacterial or fungal extension, and carries significant morbidity if not addressed rapidly.^[19] Other risks include orbital cellulitis and intracranial abscesses, emphasizing the need for vigilant monitoring in confirmed cases.^[19]

Surgical approaches and procedures

The transsphenoidal approach to the sphenoid sinus has evolved significantly since its inception in the early 20th century. In 1907, Hermann Schloffer performed the first transsphenoidal surgery via a sublabial route for a pituitary adenoma, marking the beginning of direct access through the nasal cavity and sphenoid sinus.^[51] This microscopic technique, refined by Oskar Hirsch in 1910 through a transseptal endonasal method, became the standard until the 1990s, when fully endoscopic approaches were introduced, offering improved visualization and reduced morbidity.^[52] Pioneered by Jankowski and colleagues in 1992, endoscopic transsphenoidal surgery utilized rigid endoscopes for bimanual dissection, transitioning from microscope-assisted to purely endoscopic techniques by the mid-1990s.^[53]^[54] The endoscopic transsphenoidal approach provides minimally invasive access to the sphenoid sinus and sella turcica primarily through the nasal cavity, avoiding external incisions. It is the preferred method for resecting pituitary adenomas and other sphenoid sinus pathologies, achieving gross total resection in approximately 70-80% of cases and endocrinologic remission in 70-92% of hormone-secreting tumors.^[55]^[56] The procedure typically involves three stages: nasal, sphenoid, and sellar. In the nasal stage, the endoscope is inserted through one or both nostrils, often with a partial posterior septectomy to widen access if a bilateral approach is needed.^[57] The sphenoid stage entails a sphenoidotomy by incising the posterior sphenoid wall, followed by exposure of the sellar floor in the sellar stage, where the dura is opened for tumor resection using microinstruments.^[58]^[59] Image-guided navigation systems enhance precision during endoscopic transsphenoidal surgery, particularly in cases of anatomical variations such as Onodi cells or asymmetric pneumatization that may alter surgical landmarks. These systems fuse preoperative CT and MRI images to provide real-time 3D tracking of instruments relative to the patient's anatomy, reducing the risk of complications by up to 50% in complex variants.^[60]^[61] Common complications of transsphenoidal surgery include cerebrospinal fluid (CSF) leak, occurring in 2-5% of cases, often managed with lumbar drainage or nasal packing.^[62]^[63] Internal carotid artery injury is rare, with an incidence of less than 1%, but can lead to severe hemorrhage or stroke if not promptly controlled intraoperatively.^[64]^[65] Vision loss from optic nerve injury is infrequent (<1%), attributed to the close proximity of the optic chiasm and nerves to the surgical field.^[66] In pediatric patients, transsphenoidal surgery is generally delayed until age 7 or later due to incomplete sphenoid sinus pneumatization before this time, which complicates access and increases risks.^[67]^[68] By age 6-7, the sphenoid sinus reaches 90% pneumatization, allowing safer endoscopic approaches similar to adults, though with adaptations for smaller nasal anatomy.^[68]

Neoplasms and other pathologies

Benign neoplasms of the sphenoid sinus are uncommon but can include mucoceles, which arise from obstruction of the sinus ostium leading to accumulation of mucus and subsequent expansion of the sinus cavity. These lesions are encapsulated, epithelium-lined masses that cause bony erosion and may mimic more aggressive pathologies due to their locally destructive nature. Mucoceles account for approximately 1-2% of all paranasal sinus mucoceles, with sphenoid involvement being particularly rare and often presenting with headaches, visual disturbances, or cranial nerve deficits. Meningiomas may also invade the sphenoid sinus, typically originating from adjacent structures such as the sphenoid wing or sella turcica, and are histologically benign despite potential bone invasion and hyperostosis. Primary ectopic meningiomas within the sphenoid sinus are exceptionally rare, arising from arachnoid cell rests, and can extend into the cavernous sinus or optic canal, complicating diagnosis and management. Treatment for benign neoplasms like mucoceles and meningiomas generally involves endoscopic surgical marsupialization or resection to relieve symptoms and prevent complications, with observation for asymptomatic cases.^[69] Malignant neoplasms in the sphenoid sinus are even rarer, representing a small fraction of paranasal sinus cancers, which overall constitute less than 1% of head and neck malignancies. Squamous cell carcinoma is the most common histologic type among paranasal sinus tumors but infrequently originates in the sphenoid sinus, often presenting with nonspecific symptoms like headache or diplopia due to its deep location. Esthesioneuroblastoma, a neuroectodermal tumor typically arising from the olfactory epithelium, can rarely involve the sphenoid sinus as an atypical or advanced presentation, exhibiting aggressive local invasion. The 5-year relative survival rate for paranasal sinus cancers, including those affecting the sphenoid, varies by stage but is approximately 40-60% overall, with localized disease faring better at around 85% and distant metastasis reducing it to about 43%. Management of malignant neoplasms requires multidisciplinary approaches, including endoscopic or open surgical resection, adjuvant radiation therapy, and chemotherapy (e.g., cisplatin-based regimens), tailored to histology and stage per NCCN guidelines.^[70] Congenital anomalies impacting the sphenoid sinus include encephaloceles, where brain tissue herniates through dehiscences in the sinus floor or walls, often as part of basal encephaloceles associated with neural tube closure defects. These are rare, comprising a subset of congenital encephaloceles that may lead to cerebrospinal fluid (CSF) leaks, endocrine dysfunction, or visual impairment if involving the pituitary or optic pathways. Choanal atresia, a congenital obstruction of the posterior nasal choanae involving bony or membranous tissue near the sphenoid, can indirectly affect sphenoid sinus development but does not typically originate within the sinus itself. Treatment for congenital anomalies like encephaloceles involves surgical repair, often endoscopic, to close defects and prevent CSF leaks, while choanal atresia is corrected via transnasal endoscopic dilation or resection in neonates.^[71] Traumatic pathologies of the sphenoid sinus often result from midfacial or skull base fractures due to high-impact injuries, leading to complications such as CSF rhinorrhea in 2-20% of skull base fracture cases. These fractures may disrupt the thin bony walls, allowing dural tears and leakage of CSF into the sinus and nasal cavity, with risks of meningitis if untreated. Repair typically involves endoscopic approaches with vascularized flaps to seal the defect and prevent recurrent leaks.^[72] Diagnosis of sphenoid sinus neoplasms and pathologies relies on advanced imaging, with magnetic resonance imaging (MRI) preferred for delineating soft tissue involvement, tumor extent, and relation to critical structures like the optic nerves or cavernous sinus. Positron emission tomography (PET) with 18F-FDG is valuable for assessing malignancy, metabolic activity, and staging, offering high sensitivity for detecting metastases. Definitive diagnosis requires biopsy, often performed endoscopically, to confirm histology and guide treatment, as imaging alone cannot reliably distinguish benign from malignant lesions.

References

[1]
Sphenoid Sinus: What It Is & Function - Cleveland Clinic
Mar 12, 2025 · Your sphenoid sinuses are the paranasal sinuses situated the farthest within your skull. They contain cells that make mucus.
[2]
Sphenoid sinus | Radiology Reference Article - Radiopaedia.org
Aug 23, 2025 · The sphenoid sinuses are paired spaces formed within the body of the sphenoid bone, communicating with the roof of the nasal cavity via the sphenoethmoidal ...
[3]
The Paranasal Sinuses - Structure - Function - TeachMeAnatomy
### Summary of Sphenoid Sinuses
[4]
Anatomy, Head and Neck, Nose Paranasal Sinuses - NCBI - NIH
The sphenoid sinus, present only in humans and primates,[16] can be identified in radiographs from the age of 2.[17] It keeps developing throughout life but ...
[5]
Paranasal Sinus Anatomy - Medscape Reference
Feb 10, 2025 · Sphenoid ostium and sphenoethmoid recess The natural sphenoid sinus ostium is located 1.5 cm superior to the posterior choanae on the anterior ...Missing: diameter | Show results with:diameter
[6]
Volumetric analysis of the maxillary, sphenoid and frontal sinuses
The mean volume of maxillary, sphenoid and frontal sinuses in the four groups were 12.75 ± 4.38 cc; 4.00 ± 1.99 cc and 2.92 ± 2.57 cc, respectively. In both ...
[7]
A computed tomography comprehensive evaluation of the ostium of ...
Jun 29, 2021 · The average size of both sphenoid sinus ostia was 0.31 cm for both genders (0.29 cm for females and 0.33 cm for males). Statistically ...
[8]
Sphenoid sinus anatomical variants and pathologies: pictorial essay
May 18, 2023 · Anatomy. The sphenoid sinus (SS) is one of the four paired PNSs within the sphenoid bone body divided by the septum. The sphenoid sinus ostium ...
[9]
SPHENOID SINUS: ANATOMIC STUDY, WITH CONSIDERATION ...
The sphenoid sinus reflects its anatomic relations in its walls. Adjacent structures, present before the development of the sinus, produce irregularities.
[10]
Neurovascular relationships of the sphenoid sinus in
25 sphenoid sinuses were examined in cadavers, with attention to the neural and vascular structures in the lateral wall of the sinus.Results · Sphenoid Sinus · Carotid Arteries<|control11|><|separator|>
[11]
Anatomic Variation of Sphenoid Sinus and Related Structures in ...
This study indicates the possibility of a racial anatomical variation of the sphenoid sinus in the Libyan population.
[12]
Variant Neurovascular Relations of the Sphenoid Sinus in... - LWW
Dehiscence of the ICA occurred unilaterally with a prevalence of 34, 10.1%. We did not observe bilateral ICA dehiscence. ICA protrusion was recognised in 83 ...Missing: bony | Show results with:bony<|separator|>
[13]
Anatomy, Head and Neck, Maxillary Nerve - StatPearls - NCBI - NIH
Jun 5, 2023 · These small branches travel through the inferior orbital fissure and contribute to the innervation of orbital wall, sphenoidal sinus, and ...
[14]
Neuroanatomy, Superior Cervical Ganglion - StatPearls - NCBI - NIH
The superior cervical ganglia are involved in the autonomic nervous system. They are involved explicitly with sympathetic efferent innervation, particularly to ...Missing: sphenoid | Show results with:sphenoid
[15]
Anatomy, Head and Neck, Sinus Function and Development - NCBI
The sensorial nerve supply of the sphenoidal sinuses is from the posterior ethmoidal nerves, and its parasympathetic secretomotor fibers are from orbital ...Missing: innervation autonomic<|separator|>
[16]
Intranasal and Sinus Anatomy - EyeWiki
Sphenoid Sinuses. Sphenoid sinus anatomy. The sphenoid sinuses are the most posterior of paranasal sinuses. They are of irregular shape and are ...
[17]
Vascular and Neurological Complications in Sphenoid Sinusitis - NIH
Aug 5, 2024 · Sphenoid sinusitis causing septic cavernous sinus thrombosis and internal carotid artery (ICA) stenosis or occlusion is a rare complication but ...
[18]
Risky anatomical variations of sphenoid sinus and surrounding ...
Sep 3, 2022 · This study aimed to examine the relationship between the sphenoid sinus (SS) and surrounding vital structures such as the internal carotid artery (ICA) and ...
[19]
Sphenoid Sinus Pneumatization Types and Correlation with ... - NIH
May 10, 2023 · The prevalence of presellar, sellar, and postsellar types was 28.2%, 39.4%, and 32.4%, respectively in a study by Refaat and Basha [8]. In a ...
[20]
Prevalence of Anatomical Variations of Sphenoid Sinus and Its ...
Out of 114 cases of pneumatized sphenoid sinus, 5.2% cases were conchal type, 26.3% cases Presellar type and 68.4% cases sellar type. The one or more adjacent ...<|separator|>
[21]
The Evaluation of Variations in Patterns of Sphenoid Sinus ...
Mar 15, 2022 · This study aims to explore the various patterns of pneumatization in the sphenoid sinus and their prevalence in the South Indian population.
[22]
Sphenoethmoidal air cell | Radiology Reference Article
Mar 1, 2025 · The incidence of sphenoethmoidal air cells is variable, reported in 3.4 to 60% of individuals 1,8; the discrepancy of these rates of incidence ...Terminology · Clinical presentation
[23]
Computed Tomographic Study on the Prevalence of the Onodi Cell
The prevalence of Onodi cell was 16.4% and was only observed unilaterally with a slightly lower frequency on the right (27, 8.0%) than the left (28, 8.3%).
[24]
[PDF] The Septation of the Sphenoidal Air Sinus. A Cadaveric Study
The bending or deviation of the sinus septum towards one of the sides, results in the sphenoidal sinuses being unequal, with the larger sinus termed the ...
[25]
Sphenoid sinus septations and their interconnections with ... - NIH
The aim of the study was to determine the anatomical relationship between the sphenoidal sinus septation patterns and the ICA course based on our own material ...
[26]
Pneumatization of the sphenoid sinus in Chinese: the differences ...
Apr 25, 2011 · Analysis reveals that the presellar sinus type is more prevalent in Chinese than in Caucasians (P = 0.02), whereas the sellar type is less ...
[27]
Radio-anatomic variability in sphenoid sinus pneumatization with its ...
There were significant differences in the conchal, sellar, presellar and postsellar types of pneumatization with over all prevalence ranging from 0.0–18%, 14.5– ...
[28]
[PDF] Sphenoid bone and its sinus - anatomo-clinical review of the ...
The sphenoid sinuses start their development around the 3–4 month of gestation [19, 20], through bilateral intussusception of the nasal mucosa toward the ...
[29]
embryonic development and postnatal pneumatization of the ...
Aug 1, 2025 · The sphenoid sinus is the most variable and last to complete its pneumatization compared to the other para-nasal sinuses, which has direct ...Missing: nasopharyngeal ectoderm
[30]
Development of the sphenoid sinus from newborn to age 18
The sphenoid sinus (SS) is an important anatomical formation in terms of its location and relationship with important neurovascular structures.
[31]
Development of the Sphenoid Sinus in Japanese Children - NIH
Oct 26, 2022 · This study aimed to clarify the growth pattern of the SS in Japanese children using three-dimensional computed tomography (CT).
[32]
[PDF] Clinical and Radiological Significance of Anatomical Variations in ...
Apr 18, 2025 · ... hypoplasia (17%), maxillary sinus hypoplasia (6.6%), and sphenoid sinus hypoplasia (5%). Unilateral variations were more common than.
[33]
Sinus Center - Otolaryngology - UC Davis Health
While the exact purpose of the paranasal sinuses is unclear, it is theorized that they play a role in: decreasing weight in the head, creating resonance to the ...
[34]
Anatomy, Sphenoid Bone - StatPearls - NCBI Bookshelf
Blood Supply and Lymphatics The blood vessels pass through the foramina present in the wings of the sphenoid bone. The ophthalmic artery passes through the ...
[35]
Physiology and pathophysiology of respiratory mucosa of the nose ...
Within a paranasal sinus, mucociliary clearance will always be orientated towards the primary natural opening [44], while accessory ostia are bypassed by the ...
[36]
Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections
Secretory IgA (sIgA) serves as the first line of immune defense against foreign pathogens. sIgA facilitates clearance of pathogenic microbes by intercepting ...
[37]
Nasal Physiology: Overview, Anatomy of the Nose, Nasal Airflow
Nov 16, 2021 · Mucociliary transport relies on mucus production and ciliary function. Normally, the nose and paranasal sinuses produce approximately 1 quart ...
[38]
The Effect of Aging on Nasal Mucociliary Clearance, Beat Frequency ...
Sep 29, 1999 · The ciliary beat frequency was 13.0 ± 1.7 Hz (range: 9.1 to 17 Hz) and was identical for both male and female subjects (13.0 ± 2.1 Hz and 13.0 ± ...
[39]
Nasal mucociliary clearance in health and disease - PMC - NIH
The mean nasal mucociliary clearance rates were 11.1 mm/min for children and 12.7 mm/min for adults. Deviated nasal septum, chronic sinusitis, allergic ...
[40]
Sphenoethmoidal recess | Radiology Reference Article
May 3, 2023 · The sphenoethmoidal recess drains the posterior ethmoid air cells and sphenoid sinuses into the superior meatus of the nasal cavity.
[41]
Efficacy of mucolytics and steam therapy in the management of ... - NIH
Results showed that combination therapy of steam and mucolytics decreased the sinus thickening in a statistically significant manner compared to mucolytics ...
[42]
The pH Value as a Factor Modifying Bacterial Colonization of ...
Apr 23, 2019 · The mean pH value (independently of sex, P = .441) in the healthy sinus cavity was statistically higher than in the nasal middle meatus: 7.96 ( ...
[43]
Acute Sinusitis - StatPearls - NCBI Bookshelf - NIH
Aug 2, 2025 · Such factors may explain why most patients notice improvement with supportive measures, such as humidification, warm compresses, hydration, and ...Missing: aiding sneezing
[44]
Chronic sphenoid rhinosinusitis: management challenge - PMC
Nov 9, 2016 · Anatomy of sphenoid sinus The sphenoid sinus develops after birth. The pneumatization progresses at the age of 6 years and is completed by the ...
[45]
Chronic Sinusitis - StatPearls - NCBI Bookshelf
Chronic sinusitis is an inflammation of the sinus or nasal passages occurring for more than 12 weeks at a time.
[46]
Sphenoid Sinus Diseases: A Review of 1,442 Patients - PMC - NIH
The most common symptom is headache and its prevalence ranges from 28% in tumor lesions to 98% in inflammatory lesions.Missing: acute | Show results with:acute
[47]
Fungal Sinusitis - StatPearls - NCBI Bookshelf - NIH
The other common organisms responsible for fungal sinusitis are Mucor and Rhizopus, also known as mucormycosis.[8] A key feature of mucormycosis is necrosis of ...
[48]
Isolated Sphenoid Sinusitis: Anatomical Features for Choosing ... - NIH
May 21, 2022 · Diagnosis of isolated sphenoid sinusitis is based on anamnesis, endoscopic examination of the sphenoethmoidal area, and also on computer and ...Missing: acute | Show results with:acute
[49]
Cavernous Sinus Thrombosis - StatPearls - NCBI Bookshelf
Jun 16, 2025 · Cavernous sinus thrombosis is a rare, life-threatening disorder that can arise as a complication secondary to underlying septic conditions.Etiology · Epidemiology · Pathophysiology · Evaluation
[50]
Hermann Schloffer and the origin of transsphenoidal pituitary surgery
In 1907, at the University of Innsbruck, Hermann Schloffer performed the first transsphenoidal surgery on a living patient harboring a pituitary adenoma.
[51]
The historical evolution of transsphenoidal surgery
A brief history of endoscopic transsphenoidal surgery—from. Philipp Bozzini to the First World Congress of Endoscopic. Skull Base Surgery. Neurosurg Focus 19 ...
[52]
A brief history of endoscopic transsphenoidal surgery
In the early 1990s the pure endoscopic transsphenoidal technique (that is, use of the endoscope as the only visual- izing tool) was introduced as a result ...
[53]
[PDF] History of pituitary surgery - NAH - Sociedad Española de Neurología
Endoscopic transsphenoidal surgery was first used in 1994. From 1994 to 2020, endoscopic endonasal surgery has been the technique of choice in pituitary surgery ...
[54]
Endoscopic Transnasal Transsphenoidal Surgery
Oct 21, 2024 · Approximately 70% of patients with hormone-secreting tumors experience successful outcomes, and vision issues improve in up to 92% of cases.
[55]
Management of Pituitary Adenomas: Mononostril Endoscopic ...
The remission rate in Cushing's disease was 81%, where it achieved up to 58% surgical remission in growth hormone secreting pituitary adenomas (including the ...Missing: steps | Show results with:steps
[56]
[PDF] Endoscopic transsphenoidal pituitary surgical technique - Vula
For a bilateral approach, a partial posterior septectomy is required. ETSS is divided into 3 stages. 1. Nasal stage. 2. Sphenoid stage. 3. Sellar stage. During ...Missing: success | Show results with:success
[57]
Endoscopic pituitary surgery, transsphenoidal - Mayfield Brain & Spine
In this minimally invasive surgery, the surgeon works through the nostrils with a tiny endoscope camera and light to remove tumors with long instruments.
[58]
Endoscopic endonasal pituitary surgery: How we do it. Consensus ...
In this paper we identified a series of tips and tricks at different phases of an endoscopic endonasal pituitary surgery procedure to underline the crucial ...
[59]
Usefulness of an Image Fusion Model Using Three-Dimensional CT ...
We investigate the usefulness of multimodal assistant systems using a fusion model of preoperative three-dimensional (3D) computed tomography (CT) and magnetic ...
[60]
The use of intraoperative computed tomography navigation in ... - NIH
The use of intraoperative CT/MRI-guided neuronavigation for transsphenoidal surgery is a time-effective, safe, and technically beneficial technique for special ...
[61]
experience of 1153 consecutive cases treated at a single tertiary ...
Jun 1, 2018 · Surgical complications included postoperative cerebrospinal fluid leak (2.6%), epistaxis (1.1%), postoperative hematoma (1.1%), meningitis (1.0 ...
[62]
Risk factors for postoperative cerebrospinal fluid leakage after ... - NIH
Previous studies have reported that the incidence of CSF leakage after TSS ranged from 0.5% to 15% [7]. A national survey of complications after TSS found that ...
[63]
Inadvertent internal carotid artery (ICA) injury during ...
May 10, 2021 · The insult of the carotid artery (as any other hemorrhage) is immediate, unlike cerebrospinal fluid (CSF) leakage which can be delayed and under ...
[64]
Internal Carotid Artery Injury During the Endoscopic ... - SpringerLink
Nov 22, 2024 · In endoscopic endonasal pituitary surgeries, the incidence of injury to the ICA is estimated to be between 0.2% and 2.0%, according to available ...
[65]
Transsphenoidal surgery - Mayo Clinic
May 17, 2025 · Transsphenoidal, sometimes called transsphenoidal surgery, is a procedure to remove tumors from the pituitary gland and nearby areas in the skull base.Missing: success | Show results with:success
[66]
Approaching the Sella through the Nonpneumatized Sphenoid in ...
In most cases, the sphenoid does not become pneumatized until about age 7, which makes access to the skull base through a nonpneumatized sinus challenging ...Missing: delayed | Show results with:delayed
[67]
Special Considerations in Pediatric Endoscopic Skull Base Surgery
As discussed previously, sphenoid pneumatization does not start until 2–4 years of age. The sphenoid sinus is 90% pneumatized by 6–7 years [81]. Patients ...