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Pituitary gland

The pituitary gland is a small, pea-sized endocrine gland situated at the base of the brain within a depression in the sphenoid bone known as the sella turcica.^[1] It is often called the "master gland" due to its central role in regulating the endocrine system by producing and releasing hormones that control growth, metabolism, reproduction, stress responses, lactation, water balance, and childbirth.^[2] The gland consists of two primary lobes—anterior (adenohypophysis) and posterior (neurohypophysis)—with the anterior lobe comprising about 80% of its mass and actively secreting hormones, while the posterior lobe primarily stores and releases hormones synthesized in the hypothalamus.^[2] Connected to the hypothalamus via the pituitary stalk, it receives regulatory signals that ensure precise hormonal output.^[1] The anterior pituitary produces six key hormones: growth hormone (GH), which promotes tissue growth and metabolic regulation; adrenocorticotropic hormone (ACTH), which stimulates cortisol production in the adrenal glands for stress response; thyroid-stimulating hormone (TSH), which directs thyroid hormone synthesis for metabolism; follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which govern reproductive functions in the gonads; and prolactin, which supports lactation in mammary glands.^[2] These secretions are modulated by hypothalamic releasing and inhibitory factors, such as growth hormone-releasing hormone (GHRH) for GH and dopamine for prolactin inhibition.^[2] In contrast, the posterior pituitary does not synthesize hormones but stores and discharges oxytocin, which facilitates uterine contractions during childbirth and milk ejection, and antidiuretic hormone (ADH, or vasopressin), which promotes water reabsorption in the kidneys and vasoconstriction to maintain blood pressure and fluid balance.^[1] These posterior hormones are produced by neuronal cell bodies in the hypothalamus and transported via axons to the pituitary for release in response to neural stimuli like suckling or changes in blood osmolality.^[2] Overall, the pituitary gland's functions are vital for homeostasis, with disruptions like tumors (adenomas) or hypopituitarism potentially leading to widespread hormonal imbalances that require medical intervention, such as hormone replacement therapy.^[1] Its embryological origins trace to the Rathke's pouch, a derivative of the oral ectoderm for the anterior lobe and neural ectoderm for the posterior, highlighting its dual developmental nature.^[3] Despite its small size—typically weighing less than 1 gram—the pituitary influences nearly every major organ system through its endocrine orchestration.^[1]

Anatomy

Location and macroscopic features

The pituitary gland, also known as the hypophysis, is situated at the base of the brain, immediately inferior to the hypothalamus to which it is attached via the infundibulum, a stalk-like structure that pierces the diaphragma sellae—a dural fold forming the roof of the sella turcica.^[4] The gland is housed within the sella turcica, a bony depression in the superior aspect of the sphenoid bone near the center of the cranial base, with its inferior, anterior, and posterior surfaces enveloped by this bony enclosure.^[5] Macroscopically, the pituitary gland presents as an oval or bean-shaped organ, measuring approximately 12 mm in transverse diameter, 8 mm in anteroposterior diameter, and 3–11 mm in height, with an average adult weight of 0.5 g and a typical volume ranging from 200 to 500 mm³.^[4]^[5]^[6] The arterial blood supply arises primarily from branches of the internal carotid arteries, including the superior hypophyseal arteries—which originate from the internal carotid or posterior communicating artery and supply the infundibulum, median eminence, and anterior lobe via the hypophyseal portal system—and the inferior hypophyseal arteries, which arise from the meningohypophyseal trunk and supply the posterior lobe.^[4]^[5] Venous drainage is provided by the anterior and posterior hypophyseal veins, which empty into the cavernous sinus and intercavernous sinuses.^[4] Anatomically, the gland lies in close relation to critical structures: superiorly covered by the diaphragma sellae and anterosuperiorly adjacent to the optic chiasm; anteroinferiorly bordering the sphenoid sinus; and laterally abutting the cavernous sinuses, which house cranial nerves III, IV, V1, V2, VI, and the internal carotid artery.^[4]^[5]

Anterior pituitary

The anterior pituitary, also known as the adenohypophysis, is the glandular portion of the pituitary gland responsible for the synthesis and secretion of multiple hormones. It constitutes approximately 75% of the total pituitary volume and is derived from Rathke's pouch, an ectodermal invagination of the oral epithelium during embryonic development.^[3]^[7]^[8] Histologically, the anterior pituitary consists of chromophils, which are hormone-producing cells that stain prominently with acidic or basic dyes, and chromophobes, which have minimal staining due to low hormonal content. Chromophils are subdivided into acidophils (staining red or orange, comprising about 40% of cells) and basophils (staining blue, comprising about 10%). The remaining cells are chromophobes (about 50%), which appear pale and may represent degranulated chromophils or undifferentiated stem cells. Within these categories, five distinct endocrine cell types are present: somatotrophs, lactotrophs, thyrotrophs, gonadotrophs, and corticotrophs, each producing specific hormones.^[9]^[10]^[11] Structurally, the anterior pituitary is divided into three parts: the pars distalis, which forms the bulk of the lobe and is the primary site of hormone secretion; the pars tuberalis, a thin sheath of cells encircling the infundibulum (pituitary stalk); and the pars intermedia, a rudimentary layer in humans that separates the anterior and posterior lobes but is more prominent in other mammals. These components are arranged in cords and follicles supported by a rich sinusoidal capillary network.^[9]^[3]^[12] The anterior pituitary is vascularized by the hypophyseal portal system, where superior hypophyseal arteries form a primary capillary plexus in the median eminence of the hypothalamus. Hypothalamic releasing hormones drain via portal veins into a secondary capillary plexus within the anterior pituitary, enabling direct regulatory input without systemic circulation.^[9]^[13]

Posterior pituitary

The posterior pituitary, or neurohypophysis, derives from the neuroectoderm of the diencephalon as a downward extension of the hypothalamic floor.^[14] This neural structure forms during embryonic development through evagination of the infundibulum, integrating with the anterior pituitary to create the complete gland.^[15] Structurally, it comprises the pars nervosa as its primary component—a bulbous region for hormone storage—and the infundibular stem, a narrow stalk linking it directly to the hypothalamus.^[5] Histologically, the posterior pituitary consists mainly of unmyelinated axons from hypothalamic neurons, interspersed with pituicytes, which function as supportive glial cells similar to astrocytes.^[16] These axons terminate in swellings known as Herring bodies, which are axonal dilatations that accumulate and store peptide hormones prior to release.^[17] The tissue lacks secretory cells, emphasizing its role as a neurohemal organ for hypothalamic hormone deposition rather than synthesis.^[18] The unmyelinated axons project from magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus, forming the hypothalamo-neurohypophyseal tract that traverses the infundibular stem.^[19] Vascularization occurs via direct arterial supply from the inferior hypophyseal artery, a branch of the internal carotid, bypassing any intermediary portal circulation.^[5] This direct perfusion supports the rapid transport and storage of hormones like oxytocin and vasopressin within the Herring bodies.^[4]

Intermediate lobe and supporting structures

The intermediate lobe, also known as the pars intermedia, is a rudimentary thin layer of tissue situated between the anterior and posterior lobes of the pituitary gland in humans.^[5] It consists primarily of scattered melanotroph cells derived from the posterior wall of Rathke's pouch, along with follicles containing a colloidal matrix that represent remnants of the embryonic Rathke's cleft.^[3] These cells are characterized by periodic acid-Schiff (PAS)-positive staining and include corticotroph-like elements that exhibit basophilic invasion into adjacent regions with age.^[3] In histological sections, the lobe appears as a narrow zone with minimal glandular mass compared to the more prominent anterior lobe.^[20] Supporting structures of the pituitary gland, including the intermediate lobe, encompass a fibrous capsule that envelops the entire gland and serves as a continuation of the leptomeningeal sheath.^[21] This capsule provides mechanical protection and is thicker dorsally over the intermediate and anterior regions, featuring fibroblast-like cells and abundant capillaries.^[21] The gland resides within the sella turcica of the sphenoid bone, roofed by the dural diaphragma sellae, which separates it from the optic chiasm and contributes to compartmentalization.^[20] Laterally, the cavernous sinuses surround the gland, housing cranial nerves and vascular elements.^[20] Notably, the posterior pituitary and median eminence lack a blood-brain barrier due to fenestrated capillaries, allowing direct exchange with circulating factors, whereas the intermediate lobe's vascular supply derives from anastomoses between anterior and posterior capillary beds.^[20] Innervation of the pituitary, including the intermediate lobe, is predominantly hypothalamic, with the pars intermedia receiving inputs via the tuberoinfundibular system from nuclei such as the arcuate and paraventricular.^[20] Sympathetic fibers from the superior cervical ganglion reach the gland indirectly through the cavernous sinus and internal carotid plexus, influencing vascular tone and potentially thermoregulation, though direct innervation to the intermediate lobe is limited.^[20] Parasympathetic contributions are minor, arising from brainstem reticular formation projections via the dorsal longitudinal fasciculus, but do not prominently target the intermediate region.^[20] In humans, the intermediate lobe exhibits minimal function, primarily involving the processing of pro-opiomelanocortin (POMC) into peptides such as α-melanocyte-stimulating hormone (α-MSH) and endorphins within its melanotroph and folliculostellate cells, which may serve as stem cells.^[5]^[3] These cells produce secretory granules containing α-MSH, β-endorphin, and adrenocorticotropic hormone (ACTH)-related products, distinct from those in the anterior lobe.^[3] Remnants or cysts of the intermediate lobe are occasionally visible on imaging as small, low-signal structures near the cleft.^[3] Evolutionarily, the intermediate lobe is more prominent in non-mammalian vertebrates, such as amphibians and fish, where melanotrophs play a key role in skin pigmentation and adaptation via robust α-MSH production, reflecting its conserved origin across vertebrate classes before becoming vestigial in humans.^[22]

Physiology

Anterior pituitary hormones

The anterior pituitary, also known as the adenohypophysis, synthesizes and secretes six major peptide and glycoprotein hormones that play essential roles in regulating growth, metabolism, reproduction, stress response, and lactation. These hormones are produced by distinct cell types within the anterior pituitary and are released into the systemic circulation in a pulsatile pattern, with secretion influenced by circadian rhythms, sleep stages, and physiological stressors such as acute stress or fasting. Secretion is primarily controlled by hypothalamic releasing and inhibiting factors delivered via the hypophyseal portal system. Negative feedback mechanisms from peripheral target glands or tissues further modulate their release to maintain homeostasis. Growth hormone (GH), a 191-amino-acid peptide hormone secreted by somatotropes, promotes linear growth, protein synthesis, and lipolysis while antagonizing insulin action to regulate metabolism. It primarily targets the liver to stimulate production of insulin-like growth factor 1 (IGF-1), which mediates many of its anabolic effects on bone, cartilage, and muscle tissues. GH secretion exhibits a pulsatile pattern with major pulses occurring during deep sleep stages, particularly in the first few hours after sleep onset, and is enhanced by stress or exercise. Negative feedback occurs via IGF-1 and GH itself, which inhibit hypothalamic growth hormone-releasing hormone (GHRH) and stimulate somatostatin release. Prolactin (PRL), a 199-amino-acid protein hormone produced by lactotropes, primarily supports mammary gland development and milk production during lactation, while also influencing reproductive behaviors and immune function. Its targets include the mammary epithelium, where it induces synthesis of milk proteins and lipids, and the gonads, where it can modulate steroidogenesis. PRL secretion is pulsatile and tonic, with peaks during sleep and postpartum periods, and is tonically inhibited under normal conditions. Feedback involves short-loop inhibition by PRL itself on the hypothalamus, though peripheral targets like the mammary gland do not provide direct negative feedback. Adrenocorticotropic hormone (ACTH), a 39-amino-acid polypeptide derived from the pro-opiomelanocortin (POMC) precursor and secreted by corticotropes, regulates the adrenal cortex to control glucocorticoid and androgen production. It binds to melanocortin-2 receptors on adrenal zona fasciculata cells, stimulating cortisol synthesis, which is crucial for stress adaptation and carbohydrate metabolism. ACTH release follows a diurnal pulsatile rhythm with elevated levels in response to stress, peaking in the early morning, and is acutely augmented by psychological or physical stressors. Cortisol provides negative feedback by inhibiting both hypothalamic corticotropin-releasing hormone (CRH) and pituitary ACTH production. Thyroid-stimulating hormone (TSH), a glycoprotein hormone consisting of alpha and beta subunits produced by thyrotropes, stimulates the thyroid gland to synthesize and release thyroid hormones (T3 and T4), which govern basal metabolic rate, thermogenesis, and development. It targets thyroid follicular cells via TSH receptors, promoting iodide uptake and hormone biosynthesis. TSH secretion is pulsatile with a circadian pattern, peaking at night during sleep, and can be suppressed by sleep deprivation. Negative feedback from circulating T3 and T4 directly inhibits hypothalamic thyrotropin-releasing hormone (TRH) and pituitary TSH release. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both glycoproteins sharing a common alpha subunit but with unique beta subunits, are secreted by gonadotropes to regulate gonadal function and gametogenesis. FSH targets Sertoli cells in males to support spermatogenesis and granulosa cells in females for follicular development, while LH stimulates Leydig cells for testosterone production in males and ovulation with progesterone synthesis in females post-ovulation. Their secretion is highly pulsatile, synchronized by hypothalamic gonadotropin-releasing hormone (GnRH), with frequency and amplitude varying across the menstrual cycle or influenced by stress, which can suppress pulses. Negative feedback from gonadal steroids (e.g., estrogen, testosterone) and peptides like inhibin modulates GnRH and gonadotropin release, with inhibin specifically inhibiting FSH.

Posterior pituitary hormones

The posterior pituitary, also known as the neurohypophysis, stores and releases two primary hormones: vasopressin (also called antidiuretic hormone or ADH) and oxytocin. These hormones are synthesized in the hypothalamus rather than in the pituitary itself, distinguishing them from the anterior pituitary hormones. Both are nonapeptides—small peptides consisting of nine amino acids—with a characteristic disulfide bridge between cysteine residues at positions 1 and 6, and they differ by only two amino acids in their sequence.^[23]^[24] Vasopressin and oxytocin are produced by magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus. Once synthesized as part of larger precursor proteins (preprohormones), they are processed into their active forms and packaged into secretory vesicles along with neurophysins (carrier proteins) and glycopeptide fragments. These vesicles are transported down axons via the hypothalamo-hypophyseal tract to the posterior pituitary, where they accumulate in nerve terminals known as Herring bodies for storage until release.^[23]^[15]^[24] The release of these hormones from the posterior pituitary is triggered by neural signals originating in the hypothalamus. For vasopressin, secretion is primarily stimulated by increased plasma osmolality (detected by osmoreceptors in the organum vasculosum of the lamina terminalis) or decreased blood volume (sensed by baroreceptors), with a typical threshold osmolality of around 284 mOsm/kg; it is inhibited by factors such as atrial natriuretic peptide or water intake. Oxytocin release is evoked by specific stimuli like nipple stimulation during suckling (for milk ejection) or cervical/uterine stretching during labor. Upon stimulation, action potentials propagate along the axons, causing calcium influx and exocytosis of the vesicles into the bloodstream.^[23]^[15]^[25] Vasopressin plays key roles in maintaining fluid balance and blood pressure. As an antidiuretic hormone, it acts on V2 receptors in the renal collecting ducts to increase water permeability via aquaporin-2 channels, promoting water reabsorption and concentrating urine to prevent dehydration. At higher concentrations, it binds V1 receptors on vascular smooth muscle to induce vasoconstriction, thereby elevating blood pressure during hypovolemia.^[23]^[25]^[15] Oxytocin primarily facilitates reproductive functions. It stimulates uterine smooth muscle contraction through oxytocin receptors, aiding in labor progression and postpartum hemorrhage control. In lactation, it triggers myoepithelial cell contraction in the mammary glands, ejecting milk from alveoli into ducts during breastfeeding. Additionally, oxytocin influences social behaviors, such as pair bonding and maternal care, by modulating neural circuits in the brain, though these effects extend beyond peripheral release.^[23]^[24]^[15]

Hypothalamic regulation

The hypothalamus exerts precise control over pituitary gland function through distinct vascular and neural pathways, forming the core of the hypothalamic-pituitary axis. This regulation ensures coordinated endocrine responses to physiological needs, integrating neural inputs with hormonal signals to maintain homeostasis.^[26] For the anterior pituitary, regulation occurs primarily via the hypophyseal portal system, a specialized capillary network originating from the superior hypophyseal arteries in the median eminence of the hypothalamus. Hypothalamic neurons release releasing hormones such as thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), and gonadotropin-releasing hormone (GnRH), along with inhibiting factors like dopamine, directly into this portal circulation for transport to the anterior pituitary. These factors bind to receptors on pituitary cells, stimulating or suppressing the synthesis and secretion of anterior hormones; for instance, TRH from paraventricular nucleus neurons promotes thyroid-stimulating hormone (TSH) release, while dopamine from arcuate nucleus neurons tonically inhibits prolactin. The arcuate, paraventricular, and supraoptic nuclei house the key parvocellular neurons responsible for producing these regulatory peptides, allowing rapid modulation of anterior pituitary output based on central nervous system inputs.^[13]^[26]^[27] In contrast, posterior pituitary regulation involves direct neural connections through the hypothalamo-neurohypophyseal tract, comprising axons from magnocellular neurons in the paraventricular and supraoptic nuclei. These neurons synthesize oxytocin and vasopressin (antidiuretic hormone) in the hypothalamus, with hormones packaged into vesicles and transported along axons to the posterior pituitary for storage and release into the systemic circulation upon appropriate stimuli, such as neural firing patterns. This axonal pathway enables immediate, activity-dependent hormone discharge without intermediary vascular transport.^[13]^[26] The hypothalamus integrates feedback from peripheral signals to fine-tune pituitary regulation, sensing factors like blood glucose levels to adjust hormone release. For example, hypoglycemia stimulates growth hormone-releasing hormone (GHRH) from arcuate nucleus neurons while inhibiting somatostatin, promoting growth hormone secretion from the anterior pituitary to mobilize energy stores. Such feedback loops, including ultra-short, short, and long types, prevent over- or under-secretion and maintain endocrine balance.^[13]^[26] Disruptions to the pituitary stalk, such as from trauma or tumors, profoundly impair this regulation, with the anterior pituitary typically more affected due to interruption of the delicate hypophyseal portal system, leading to deficiencies in multiple anterior hormones like TSH and gonadotropins. Posterior function may partially recover via axonal regeneration or revascularization, but stalk section often results in transient or permanent vasopressin deficiency, manifesting as central diabetes insipidus.^[13]^[26]

Development

Embryonic origins

The pituitary gland originates from two distinct embryonic tissues derived from the ectoderm germ layer. The anterior pituitary, or adenohypophysis, develops from the oral ectoderm as an upward invagination known as Rathke's pouch, which forms around the third to fourth week of gestation.^[3] In contrast, the posterior pituitary, or neurohypophysis, arises from the neuroectoderm through a downward evagination of the ventral diencephalon, forming the infundibulum by the fifth week.^[15] These dual origins reflect the gland's functional duality, with the anterior portion becoming endocrine tissue and the posterior serving as a neural extension.^[28] During early development, Rathke's pouch elongates and contacts the infundibulum between weeks 6 and 8, leading to the separation of the pouch from the oral epithelium by weeks 6 to 8 and the establishment of a fused bilobed structure by weeks 8 to 10.^[3] The definitive pituitary gland forms by weeks 12 to 16, as the anterior lobe differentiates into distinct cell types and the posterior lobe integrates axonal projections from the hypothalamus.^[28] This fusion process is crucial for the gland's vascular and neural connections, enabling coordinated endocrine function.^[15] Cell differentiation in the anterior pituitary is regulated by key transcription factors, including PROP1, which initiates pituitary-specific gene expression and progenitor cell proliferation, and PIT1 (also known as POU1F1), which drives the development of somatotrophs, lactotrophs, and thyrotrophs.^[3] Mutations in these factors can disrupt lineage commitment, leading to hypopituitarism or selective hormone deficiencies.^[28] Additional regulators, such as HESX1 and LHX3, support early pouch formation and structural integrity.^[3] Developmental anomalies, such as craniopharyngiomas, often arise from remnants of Rathke's pouch epithelium, resulting in benign tumors that can compress the gland and impair function; these are linked to disruptions in Wnt signaling pathways, including β-catenin mutations.^[3] Hormone production begins in the fetus, with adrenocorticotropic hormone (ACTH) detectable by week 7 and growth hormone (GH) by week 8 to 12, marking the onset of endocrine activity prior to birth.^[28]

Postnatal maturation

Following birth, the pituitary gland undergoes rapid structural and functional maturation, building on its embryonic foundations to support growth and endocrine regulation. In infancy and early childhood, the gland expands significantly through increased cell proliferation and differentiation, particularly in the anterior lobe, where somatotrophs and other hormone-producing cells multiply. This phase is marked by a surge in growth hormone (GH) secretion from the pituitary in infancy, followed by a nadir in mid-childhood, and a major peak during puberty that drives longitudinal bone growth and metabolic adaptations essential for development.^[29]^[30] The volume of the pituitary increases approximately 2-3 fold from neonatal levels (typically around 100-150 mm³) to adult dimensions (300-500 mm³), as evidenced by serial MRI studies.^[31]^[32] During puberty, further maturation occurs with the activation of the hypothalamic-pituitary-gonadal axis, where rising sex steroids from the gonads establish negative and positive feedback loops on pituitary gonadotrophs. This enhances luteinizing hormone (LH) and follicle-stimulating hormone (FSH) pulsatile release, synchronizing reproductive maturation and secondary sexual characteristics. The gland's overall size continues to grow, reaching a maximum height of about 10 mm, with the anterior lobe developing a more convex contour due to heightened cellular activity. Environmental factors play a key role here; optimal nutrition, particularly adequate energy intake and micronutrients like zinc and iodine, supports GH and gonadotropin surges, while chronic stress can disrupt hypothalamic signaling, potentially delaying pubertal onset by altering corticotropin-releasing hormone dynamics.^[33]^[34] In adulthood, pituitary size stabilizes at around 8-9 mm in height, with imaging confirming a plateau after the early 20s. However, an age-related decline in GH and prolactin (PRL) secretion begins in the third decade, with GH pulse amplitude decreasing by up to 50% by age 60 due to reduced somatotroph responsiveness and hypothalamic drive.^[30] PRL levels similarly drop, especially nocturnally, by 30-40% in older adults, linked to diminished lactotroph function.^[35] Sexual dimorphism emerges prominently, with female pituitaries averaging 10-20% larger than males, driven by estrogen's mitogenic effects on pituitary progenitors and increased lactotroph proliferation during reproductive years.^[36]

Clinical significance

Disorders of the anterior pituitary

Disorders of the anterior pituitary encompass a range of pathologies characterized by either insufficient (hypofunction) or excessive (hyperfunction) hormone production, primarily affecting growth hormone (GH), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL).^[37] Hypofunction, known as hypopituitarism, results from damage to the pituitary tissue, leading to partial or complete loss of anterior hormone secretion, while hyperfunction is most commonly driven by benign adenomas that autonomously secrete hormones.^[38] These conditions can manifest with symptoms such as fatigue, infertility, and metabolic disturbances, often requiring prompt diagnosis to prevent complications like adrenal crisis or growth impairment.^[39] Hypopituitarism arises from various etiologies, including pituitary tumors (accounting for approximately 50-60% of cases), traumatic brain injury (prevalent in 30-70% of severe cases), postpartum hemorrhage, radiation therapy, and autoimmune processes.^[40] In primary hypopituitarism, the pituitary gland itself is affected, whereas secondary forms stem from hypothalamic damage. Common symptoms include fatigue, weakness, weight changes, cold intolerance (from TSH deficiency), hypotension and hypoglycemia (from ACTH deficiency), infertility and amenorrhea (from gonadotropin deficiency), and reduced quality of life (from GH deficiency).^[39] Growth hormone deficiency, a frequent component, leads to short stature in children and increased visceral fat, dyslipidemia, and muscle weakness in adults.^[38] Sheehan's syndrome exemplifies postpartum hypopituitarism, caused by ischemic necrosis of the enlarged anterior pituitary following severe hemorrhage and hypovolemic shock during delivery; it presents acutely with failure to lactate and persistent hypotension, progressing chronically to hypothyroidism symptoms, adrenal insufficiency, and amenorrhea.^[41] Hyperfunction of the anterior pituitary is predominantly due to pituitary adenomas, which constitute about 10-15% of all intracranial tumors and are classified as functioning (hormone-secreting) or non-functioning based on their secretory activity.^[42] Approximately 53% of these adenomas are prolactinomas, leading to PRL excess that causes galactorrhea, amenorrhea, and infertility in women, and erectile dysfunction in men.^[43] GH-secreting adenomas result in acromegaly, characterized by coarsening facial features, enlarged hands and feet, arthritis, excessive sweating, and increased risk of diabetes and cardiovascular disease.^[42] ACTH-secreting adenomas cause Cushing's disease, manifesting as central obesity, moon facies, muscle weakness, hypertension, and glucose intolerance due to hypercortisolism.^[42] These tumors often exert mass effects, producing headaches and visual field defects from optic chiasm compression in 40-60% of cases.^[42] Autoimmune causes, such as lymphocytic hypophysitis, involve lymphocytic infiltration of the pituitary, leading to inflammation and hypofunction; it is the most common primary hypophysitis, often linked to pregnancy and associated with other autoimmune disorders in 20-50% of patients, presenting with headaches, visual disturbances, and deficiencies in ACTH, TSH, or GH.^[44] Emerging research highlights genetic factors, particularly mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene, which underlie 10-15% of familial isolated pituitary adenomas (FIPA) and up to 40% of familial somatotropinomas; these mutations promote young-onset macroadenomas with low penetrance (15-30%), predominantly GH- or PRL-secreting, and are associated with aggressive tumor behavior.^[45]

Disorders of the posterior pituitary

The posterior pituitary gland primarily stores and releases antidiuretic hormone (ADH, also known as vasopressin) and oxytocin, and disorders affecting this region disrupt water balance, electrolyte homeostasis, and potentially reproductive and social functions. These conditions often stem from damage to the hypothalamus or posterior pituitary, leading to deficiencies or excesses in hormone release, with central diabetes insipidus (CDI) and syndrome of inappropriate ADH secretion (SIADH) being the most prominent manifestations.^[46]^[47] Central diabetes insipidus arises from ADH deficiency due to hypothalamic or posterior pituitary damage, resulting in the inability to concentrate urine and excessive water loss. Common causes include tumors, head trauma, neurosurgical interventions, and infiltrative diseases such as sarcoidosis, which can infiltrate the posterior pituitary and lead to isolated CDI.^[48]^[46]^[49] Genetic conditions like Wolfram syndrome, an autosomal recessive disorder caused by mutations in the WFS1 gene, also frequently involve posterior pituitary dysfunction, manifesting as CDI alongside diabetes mellitus, optic atrophy, and deafness.^[50] Symptoms of CDI include polyuria exceeding 3 liters per day, intense thirst (polydipsia), and dehydration if fluid intake is inadequate, often leading to electrolyte imbalances such as hypernatremia.^[51]^[52] In contrast, SIADH involves excessive ADH release, causing water retention and dilutional hyponatremia, which can occur due to posterior pituitary overstimulation from central nervous system disorders or infiltrative processes.^[53] This leads to symptoms like headache, nausea, fatigue, muscle cramps, and in severe cases, seizures or coma from cerebral edema due to low serum sodium levels below 135 mEq/L.^[54]^[55] Electrolyte disturbances in both CDI and SIADH underscore the posterior pituitary's critical role in osmoregulation, with hyponatremia in SIADH contrasting the hypernatremia risk in CDI.^[56] Oxytocin deficiencies are rarer and less well-characterized but can manifest in postpartum complications, such as impaired uterine contraction leading to retained placenta or difficulties with lactation initiation.^[47] Isolated oxytocin deficiency is uncommon, often co-occurring with ADH issues in hypopituitarism, and emerging research links it to social and behavioral impairments, including reduced empathy and altered social cognition.^[57] In patients with hypothalamic damage from neurosurgery or tumors, oxytocin deficiency has been associated with lower plasma levels and deficits in empathic ability, suggesting potential roles in affective disorders.^[58] These findings highlight oxytocin's broader influence beyond reproduction, though clinical recognition remains limited due to the lack of routine testing.^[59]

Diagnostic approaches and treatments

Diagnosis of pituitary disorders typically begins with a comprehensive evaluation of clinical symptoms and biochemical testing to assess hormone levels. Blood tests measure basal levels of pituitary hormones such as adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), prolactin, and insulin-like growth factor 1 (IGF-1), which help identify deficiencies or excesses indicative of dysfunction.^[60]^[61] Urine tests may also evaluate cortisol and free cortisol to detect conditions like Cushing's disease.^[62] Imaging plays a central role in visualizing structural abnormalities. Magnetic resonance imaging (MRI) with gadolinium enhancement is the preferred modality for detecting pituitary tumors, assessing their size, location, and effects on surrounding structures like the optic chiasm, offering superior soft tissue resolution compared to computed tomography (CT) scans.^[63]^[64] CT scans are occasionally used when MRI is contraindicated or to evaluate bony involvement preoperatively.^[63] Dynamic endocrine testing provides further insight into pituitary reserve and hypothalamic-pituitary axis integrity. Stimulation tests, such as the insulin tolerance test (ITT), induce hypoglycemia to evaluate GH and cortisol responses, serving as the gold standard for diagnosing GH deficiency and secondary adrenal insufficiency, though it requires careful monitoring due to risks like severe hypoglycemia.^[65]^[66] Other tests include the cosyntropin stimulation test for ACTH reserve and the glucagon stimulation test as a safer alternative to ITT for GH assessment.^[67] For posterior pituitary disorders like diabetes insipidus (DI), the water deprivation test assesses the ability to concentrate urine, distinguishing central DI from nephrogenic or primary polydipsia by measuring urine osmolality before and after desmopressin administration.^[68]^[69] Monitoring for complications, particularly in cases of mass effect from tumors, involves visual field testing using automated perimetry to detect bitemporal hemianopia from optic chiasm compression, which is essential for serial assessment during treatment.^[70]^[71] Treatment strategies are tailored to the underlying disorder, often combining surgical, medical, and radiotherapeutic approaches. As of 2025, the Congress of Neurological Surgeons has released updated guidelines for the management of functioning pituitary adenomas, emphasizing multidisciplinary approaches.^[72] Transsphenoidal surgery, typically endoscopic, is the first-line intervention for symptomatic pituitary adenomas, allowing tumor resection through the nasal cavity with high success rates for microadenomas (over 80% remission in Cushing's disease cases).^[63]^[73] Medical therapies include dopamine agonists like cabergoline for prolactinomas, which normalize prolactin levels in up to 90% of patients and often induce tumor shrinkage.^[74] Somatostatin analogs such as octreotide control GH hypersecretion in acromegaly, while steroidogenesis inhibitors like ketoconazole or osilodrostat manage Cushing's syndrome.^[63] For central DI, desmopressin replaces antidiuretic hormone, effectively controlling polyuria and polydipsia.^[68] Hormone replacement therapy addresses deficiencies across pituitary axes. Levothyroxine restores thyroid function in TSH deficiency, hydrocortisone or prednisone replaces glucocorticoids in ACTH deficiency, and recombinant GH treats GH deficiency to improve growth and metabolism.^[75]^[76] Gonadal hormone replacement, such as estrogen or testosterone, supports puberty and fertility in LH/FSH deficiencies.^[75] Radiation therapy, including stereotactic radiosurgery or fractionated external beam, is reserved for residual or recurrent tumors unresponsive to surgery and medication, achieving tumor control in 80-90% of cases but with delayed effects on hormone normalization.^[63]^[77] Emerging research explores gene therapy for congenital hypopituitarism, with preclinical models using viral vectors to target transcription factor mutations like PROP1, though clinical trials remain limited as of 2025, highlighting ongoing challenges in delivery and specificity.^[78]

History

Early anatomical descriptions

The earliest known anatomical description of the pituitary gland dates to the 2nd century AD, when the Roman physician Galen described it as a spongy structure located in the sella turcica that served to drain phlegm or mucus from the brain ventricles to the nasal cavity via infundibular channels, a view that dominated medical thought for over a millennium.^[20] This misconception portrayed the gland primarily as a secretory organ for waste products rather than an endocrine structure, with Galen noting its proximity to the rete mirabile—a vascular network in ungulates he erroneously extended to humans as a filtration system.^[79] During the Renaissance, anatomical studies advanced through dissection and illustration, challenging Galenic ideas. In 1543, Andreas Vesalius provided the first detailed illustrations of the pituitary gland and its stalk (infundibulum) in De humani corporis fabrica, depicting it as a distinct entity named glandula pituitam cerebri excipiens and suggesting drainage via the palatine canal rather than direct ventricular ducts, though he retained the mucus-secretion hypothesis.^[20] Building on this, Johannes Vesling in the 1630s, through his Syntagma anatomicum (1647 edition), emphasized the gland's vascular connections to the brain and infundibulum, observing small vessels linking the hypothalamus to the pituitary and hinting at functional integration beyond mere drainage.^[79] In the 19th century, microscopic and pathological observations refined structural understanding. German embryologist Martin Heinrich Rathke in 1838 described the dual embryonic origins of the gland, with the anterior lobe arising from oral ectoderm (Rathke's pouch) and the posterior from neural tissue, laying groundwork for recognizing its composite nature despite gross anatomical lobes being noted earlier.^[3] French neurologist Pierre Marie in 1886 coined the term "acromegaly" and linked it to pituitary enlargement, based on autopsy findings of glandular tumors in affected patients, marking the first association of the structure with systemic disease and shifting focus from mucus to potential regulatory roles.^[80] Twentieth-century milestones clarified the gland's connections and mechanisms. British neuroendocrinologist Geoffrey Harris in the 1940s demonstrated hypothalamic control of anterior pituitary function via the hypophyseal portal system—a capillary network in the stalk transporting releasing factors—through experiments involving stalk sectioning and vascular injections, overturning prior neural-only views.^[81] This paved the way for Roger Guillemin and Andrew Schally, who in the 1970s isolated and synthesized key hypothalamic peptide hormones (e.g., TRH, GnRH) regulating pituitary secretion, earning the 1977 Nobel Prize in Physiology or Medicine and confirming the gland's endocrine integration with the brain. These discoveries corrected longstanding misconceptions of the pituitary as a mere phlegm producer, establishing its central role in hormonal orchestration.^[79]

Etymology and nomenclature

The term "pituitary gland" derives from the Latin pituita, meaning phlegm or mucus, based on the ancient belief that the structure secreted a slimy substance that drained into the nasal cavity.^[82] This nomenclature was formalized by anatomist Andreas Vesalius in his 1543 treatise De humani corporis fabrica, where he referred to it as glandula pituitaria to emphasize its perceived role in processing mucus.^[83] An alternative name, "hypophysis," originates from the Greek roots hypo- (under) and phyein (to grow), literally denoting an "undergrowth" or structure hanging below the brain.^[82] The term was reintroduced in modern anatomy by Samuel Thomas von Sömmerring in 1778 as hypophysis cerebri to describe its position and attachment beneath the cerebrum, reviving an ancient Greek usage for outgrowths.^[83] It is often specified as hypophysis cerebri to distinguish its cerebral location. The pituitary's lobes have specialized nomenclature reflecting their distinct origins and compositions. The anterior lobe, known as the adenohypophysis, combines adeno- (gland, from Greek aden) with hypophysis, highlighting its epithelial and glandular character derived from oral ectoderm.^[82] The posterior lobe, or neurohypophysis, incorporates neuro- (nerve, from Greek neuron), underscoring its neural derivation from diencephalic neuroectoderm.^[82] Functionally, the pituitary is termed the "master gland" due to its central role in regulating other endocrine organs through hormone secretion.^[5] Historically, nomenclature shifted from viewing the gland as a mucus-secreting appendage—rooted in Galenic physiology—to acknowledging its endocrine mastery, a recognition solidified in the late 19th and early 20th centuries with advances in hormonal research.^[84]

Comparative aspects

In non-human vertebrates

In fish and amphibians, the pituitary gland features a prominent intermediate lobe that primarily produces melanocyte-stimulating hormone (MSH), which regulates skin coloration and chromatophore activity for camouflage and environmental adaptation.^[22] The neurohypophysis in these groups exhibits direct vascular or neural connections to the hypothalamus, facilitating rapid hormone release without the complex portal system seen in higher vertebrates.^[22] In reptiles, the intermediate lobe is reduced in size and function compared to lower vertebrates, with diminished MSH production and less distinct separation from the anterior and posterior lobes.^[85] Birds lack an intermediate lobe entirely, resulting in a more fused structure where the posterior pituitary appears diffuse and integrated with surrounding neural tissues, adapting to their high metabolic demands and flight physiology.^[85] Among mammals, the pituitary gland generally consists of anterior, intermediate, and posterior lobes—though the intermediate lobe is rudimentary in adult humans—though gland size varies significantly with body mass—for instance, it is notably larger in cetaceans like whales to support their immense physiological scale.^[86] In rodents, the intermediate lobe remains functionally active, producing pro-opiomelanocortin (POMC)-derived peptides such as α-MSH and β-endorphin that contribute to stress responses and melanotroph regulation.^[87] Functional adaptations in the pituitary are evident in seasonal breeding patterns among ungulates, where surges in prolactin (PRL) secretion from the anterior lobe promote reproductive synchrony, lactation, and photoperiodic responses during breeding seasons.^[88] These PRL peaks, driven by hypothalamic cues, enhance gonadal activity and parental behaviors in species like sheep and deer.^[89] Evolutionary trends across vertebrates show increasing hypothalamic integration with the pituitary, progressing from direct neural innervation in fish and amphibians to a sophisticated vascular portal system in mammals, enhancing precise endocrine control and coordination of physiological processes.^[85] This trend reflects adaptations to complex environmental and metabolic demands, with the hypothalamus exerting greater regulatory influence over pituitary hormone release in higher taxa.^[90]

In invertebrates

Invertebrates lack a centralized pituitary gland analogous to that in vertebrates, instead featuring decentralized neuroendocrine systems composed of neurosecretory cells and specialized complexes that regulate key physiological processes such as reproduction, molting, and osmoregulation.^[91] These systems integrate neural and endocrine functions through dispersed clusters of cells that release hormones directly into the hemolymph or coelomic fluid, reflecting an evolutionary strategy that prioritizes flexibility over centralization.^[92] In cephalopods, the optic gland serves as a functional analog to the vertebrate pituitary, particularly in controlling reproductive maturation and senescence. Located on the optic nerve tract, this endocrine structure secretes hormones that trigger gonadal development and spawning in species like the octopus (Octopus vulgaris), after which the gland's activity leads to physiological degeneration and death in post-reproductive females.^[93] For instance, in female octopuses, optic gland activation during brooding promotes rapid maturation but culminates in starvation and tissue breakdown, ensuring a semelparous life cycle.^[94] Among arthropods, particularly crustaceans, the X-organ/sinus gland complex in the eyestalk functions as a key neuroendocrine center, producing neuropeptides that govern molting and reproduction. The X-organ consists of neurosecretory cell bodies, while the adjacent sinus gland releases hormones such as molt-inhibiting hormone (MIH), which suppresses ecdysteroid synthesis in the Y-organ to regulate the molt cycle, and gonad-inhibiting hormone (GIH), which modulates ovarian development.^[95] This complex exemplifies the decentralized nature of invertebrate endocrinology, with eyestalk ablation leading to uncontrolled molting and enhanced reproduction due to the absence of inhibitory signals.^[96] In other invertebrates like annelids and mollusks, scattered neurosecretory cells fulfill endocrine roles, including contributions to water balance. In annelids such as leeches (Hirudo medicinalis), brain-associated neurosecretory cells release neuropeptides and serotonin-like substances that influence gametogenesis and potentially osmoregulatory behaviors, integrating sensory and secretory functions in a primitive forebrain-like structure.^[97] Similarly, in mollusks like bivalves, serotonin-immunoreactive neurosecretory cells in the central nervous system regulate gill ciliary activity and mantle functions, aiding ion transport and water balance across epithelia.^[98] Recent studies in the 2020s have further illuminated the optic gland's role in cephalopod longevity, with ablation experiments demonstrating lifespan extension. For example, surgical removal of the optic glands in brooding octopuses prevents the post-spawning "death spiral," allowing survival for an additional 4–6 months through restored feeding and activity, as confirmed by analyses of steroid hormone pathways.^[99] These findings highlight conserved neuroendocrine mechanisms across phyla, though invertebrate systems remain notably diffuse compared to vertebrate centralization.^[100]

References

[1]
Pituitary Gland: What It Is, Function & Anatomy - Cleveland Clinic
The pituitary gland is a small, pea-sized endocrine gland at the base of the brain that produces hormones for growth, metabolism, reproduction, and other ...Anterior Pituitary · Adrenocorticotropic Hormone · Hyperpituitarism (Overactive...
[2]
Physiology, Pituitary Gland - StatPearls - NCBI Bookshelf
The pituitary gland, located at the base of the brain, has anterior and posterior lobes. The anterior lobe secretes hormones regulated by the hypothalamus.Introduction · Issues of Concern · Clinical Significance
[3]
Development and Microscopic Anatomy of the Pituitary Gland - NCBI
Jul 21, 2025 · We provide an overview of the molecular drivers of pituitary organogenesis and illustrate the anatomy and histology of the mature pituitary.ABSTRACT · TRANSCRIPTIONAL... · ANATOMY AND HISTOLOGY...
[4]
Pituitary Gland Anatomy - Medscape Reference
Feb 6, 2025 · Gross Anatomy. The fully developed pituitary gland (see the image below) is pea-sized and weighs approximately 0.5 g. The gland has an oval ...Missing: relations | Show results with:relations
[5]
Anatomy, Head and Neck, Pituitary Gland - StatPearls - NCBI - NIH
It is made up of two distinct regions called the anterior lobe and posterior lobe, which are functionally active. There is an intermediate lobe in between them.Introduction · Structure and Function · Embryology · Blood Supply and Lymphatics
[6]
Normative data for pituitary size and volume in the ... - PubMed
May 10, 2021 · The mean anterior pituitary lobe volume was also significantly larger in women than in men (494 ± 138 mm3 vs. 405 ± 118 mm3) (p < 0.001). There ...
[7]
Histologic:Chapter 14 - Pathology Education Instructional Resource
Anatomically, there are two gross divisions of the pituitary gland: Anterior lobe (adenohypophysis) - major portion of gland (about 75% of total pituitary gland) ...Missing: macroscopic | Show results with:macroscopic
[8]
http://x94-203-145.ahc.umn.edu/slideview/MH-149-pituitary/13-slide-1.html
[9]
Anatomy, Adenohypophysis (Pars Anterior, Anterior Pituitary) - NCBI
This plexus supplies blood to the median eminence. The blood from the median eminence would then drain via the hypophyseal portal veins in a secondary plexus.Missing: macroscopic | Show results with:macroscopic
[10]
Histology of the Adenohypophysis
Acidophils have cytoplasm that stains red or orange ; Basophils have cytoplasm that stains a bluish color ; Chromophobes have cytoplasm that stains very poorly.
[11]
Physiology, Pituitary Hormones - StatPearls - NCBI Bookshelf - NIH
The anterior pituitary hormones are produced by five different endocrine cell types (somatotropes, gonadotropes, lactotrophs, corticotropes, and thyrotropes) ...
[12]
Endocrine System - Duke Histology
The pars intermedia is very poorly developed in the human pituitary, but is prominent in the pituitaries of most other mammals. For example, in the monkey ...
[13]
Chapter 2. Hypothalamic Control of Pituitary Hormones
... anterior pituitary. The releasing-hormones gain access to the five distinct types of target cells in the anterior pituitary from this plexus and stimulate ...
[14]
Posterior Pituitary Ectopia: Another Hint Toward a Genetic Etiology
The neurohypophysis or posterior pituitary is of neuroectodermal origin and develops as a downward extension of the diencephalon (Infundibulum). Hypothalamic ...Missing: derivation | Show results with:derivation
[15]
Physiology, Posterior Pituitary - StatPearls - NCBI Bookshelf - NIH
Apr 24, 2023 · Neurohypophysis, also called the posterior pituitary gland develops from the neuroectodermal layer called the infundibulum. This grows ...Missing: derivation | Show results with:derivation
[16]
Histology of the Neurohypophysis
The bulk of the neurohypophysis is composed on largely unmyelinated axons from hypothalamic neurosecretory neurons. These axons have their cell bodies in the ...Missing: scholarly | Show results with:scholarly
[17]
Herring bodies; an electron microscopic study of local degeneration ...
Herring bodies; an electron microscopic study of local degeneration and regeneration of neurosecretory axons · 43 Citations · 34 References.
[18]
Posterior Pituitary
The posterior pituitary resembles unmyelinated nervous tissue and is composed of the nerve cell terminals that run down from neurons whose cell bodies are ...Missing: scholarly | Show results with:scholarly
[19]
Posterior Pituitary - an overview | ScienceDirect Topics
The neural lobe of the posterior pituitary is, in fact, a knoblike expansion of the stalk or infundibular stem of the brain.
[20]
Functional Anatomy of the Hypothalamus and Pituitary - NCBI - NIH
Nov 28, 2016 · Embryologic Anatomy. In contrast to the posterior pituitary, the anterior pituitary derives from the oral ectoderm as Rathke's pouch, first ...
[21]
Characterization of the rat pituitary capsule - PubMed Central
May 26, 2023 · In humans, the pituitary gland is covered by a fibrous capsule and is considered a continuation of the meningeal sheath.Missing: intermediate innervation
[22]
Functional Pituitary Networks in Vertebrates - PMC - PubMed Central
Jan 27, 2021 · The pituitary is a master endocrine gland that developed early in vertebrate evolution and therefore exists in all modern vertebrate classes.
[23]
The Neurohypophysis: Endocrinology of Vasopressin and Oxytocin
Nov 9, 2022 · This chapter will concentrate on the physiology and pathophysiology of two hormones made by the hypothalamus and posterior pituitary, ...
[24]
Oxytocin and vasopressin: linking pituitary neuropeptides and their ...
Oxytocin and arginine vasopressin (AVP) are neuropeptides synthesized in the hypothalamus and secreted from the posterior pituitary gland. Oxytocin was first ...
[25]
Physiology, Vasopressin - StatPearls - NCBI Bookshelf
Aug 14, 2023 · In route to the posterior pituitary where ADH will be released, the prohormone is cleaved to produce ADH. Go to: Organ Systems Involved. Kidneys.
[26]
Physiology, Hypothalamus - StatPearls - NCBI Bookshelf
... . Vasopressin and oxytocin are 2 hormones made in the hypothalamus itself which travel in hypothalamic neurons directly to the posterior pituitary.
[27]
Brain Hormones | Endocrine Society
Jan 24, 2022 · Found deep inside the brain, the hypothalamus produces releasing and inhibiting hormones and controls the “master gland”— the pituitary.
[28]
Pituitary Gland Development and Disease: From Stem Cell to ...
Embryos with a conditional inactivation of Gli2 in the pituitary, however, exhibit a reduction in progenitor proliferation, but the pituitary is well formed ...
[29]
Pituitary Remodeling Throughout Life: Are Resident Stem Cells ...
Jan 29, 2021 · During the first weeks after birth, an impressive growth and maturation phase is occurring in the gland during which the distinct hormonal cell ...
[30]
Measures of pituitary gland and stalk: from neonate to adolescence
Our study demonstrated the pituitary gland and stalk size data of children in various age groups from newborn to adolescent.
[31]
Hormonal and nutritional regulation of postnatal hypothalamic ...
We review the most recent knowledge regarding the major postnatal milestones in the development of metabolic, stress and reproductive hypothalamic circuitries.
[32]
Interpretation of reproductive hormones before, during and after the ...
The negative feedback from gonadal steroids on the hypothalamic–pituitary production of GnRH and gonadotropins develops by mid‐puberty and becomes dominant ...
[33]
Age-Related Pituitary Volumes in Prepubertal Children with Normal ...
The size and shape of the normal pituitary gland vary considerably and are also affected by age, sex, and hormonal environment (10–18). This is also true ...
[34]
Changes in Pituitary Function with Aging and Implications for Patient ...
The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, ...Tsh Axis In Ageing · Hpa Axis In Ageing · Prolactin Secretion In...<|control11|><|separator|>
[35]
Development and sexual dimorphism of the pituitary gland
In this study, we report that younger females had significantly larger pituitary gland volume than young males (14 to 17 years of age).
[36]
Physiology, Anterior Pituitary - StatPearls - NCBI Bookshelf - NIH
Corticotrophs produce the adrenocorticotrophic hormone (ACTH), thyrotrophs produce the thyroid-stimulating hormone (TSH), somatotrophs produce the growth ...Introduction · Cellular Level · Development · Organ Systems InvolvedMissing: five | Show results with:five
[37]
Diagnosis and Treatment of Hypopituitarism - PMC - PubMed Central
Hypopituitarism is defined as the total or partial loss of anterior and posterior pituitary gland function that is caused by pituitary or hypothalamic disorders ...
[38]
Hypopituitarism - Symptoms and causes - Mayo Clinic
Feb 13, 2024 · Hypopituitarism is a rare condition in which the pituitary gland doesn't make one or more hormones or doesn't make enough hormones.
[39]
Sheehan Syndrome - StatPearls - NCBI Bookshelf - NIH
Chronic Sheehan syndrome is diagnosed due to symptoms that occur due to hypopituitarism, and again, it can occur months to years after the initial vascular ...
[40]
Pituitary Adenoma - StatPearls - NCBI Bookshelf - NIH
Mar 27, 2023 · Pituitary adenomas are tumors of the anterior pituitary. Most pituitary tumors are slow-growing and benign. They are classified based on size or cell of origin.
[41]
Diagnosis and Management of Pituitary Adenomas: A Review
Apr 25, 2023 · Approximately 53% of pituitary adenomas are prolactinomas, which can cause hypogonadism, infertility, and/or galactorrhea.
[42]
Lymphocytic Hypophysitis - StatPearls - NCBI Bookshelf - NIH
Aug 8, 2023 · Lymphocytic hypophysitis is a rare, autoimmune condition of the pituitary gland. It causes the pituitary gland to be infiltrated by lymphocytes and can cause ...
[43]
AIP Familial Isolated Pituitary Adenomas - GeneReviews - NCBI - NIH
Jun 21, 2012 · AIP familial isolated pituitary adenoma (AIP-FIPA) is characterized by an increased risk of pituitary neuroendocrine tumors (PitNETs, also known as pituitary ...Diagnosis · Differential Diagnosis · Management · Genetic Counseling
[44]
Arginine Vasopressin Disorder (Diabetes Insipidus) - NCBI - NIH
Arginine vasopressin disorder is a clinical syndrome characterized by the passage of abnormally large volumes of urine (diabetes) that is dilute (hypotonic) ...
[45]
Neurohypophysis - StatPearls - NCBI Bookshelf - NIH
The neurohypophysis (pars posterior) is a structure that is located at the base of the brain and is the posterior lobe of the pituitary gland.Missing: diencephalon | Show results with:diencephalon
[46]
Diabetes insipidus - Symptoms and causes - Mayo Clinic
Apr 5, 2023 · Damage to the pituitary gland or hypothalamus from surgery, a tumor, a head injury or an illness can cause central diabetes insipidus. That ...
[47]
Diabetes insipidus from sarcoidosis confined to the posterior pituitary
A young white man with new-onset central diabetes insipidus was discovered to have a posterior pituitary mass on magnetic resonance imaging.
[48]
Wolfram syndrome - Genetics - MedlinePlus
Feb 14, 2022 · Wolfram syndrome is a condition that primarily causes diabetes and vision loss. Explore symptoms, inheritance, genetics of this condition.
[49]
Arginine - Vasopressin - Deficiency (Central Diabetes Insipidus)
Argininevasopressin deficiency has several causes, including a brain tumor, a brain injury, brain surgery, tuberculosis, and some forms of other diseases. · The ...(vasopressin-Sensitive... · Causes Of... · Diagnosis Of...
[50]
Central diabetes insipidus: MedlinePlus Medical Encyclopedia
Dec 31, 2023 · Central diabetes insipidus is a rare condition that involves extreme thirst and excessive urination.
[51]
Syndrome of Inappropriate Antidiuretic Hormone Secretion - NCBI
Clinical manifestations of SIADH can be due to hyponatremia and decreased ECF osmolality, which causes the water to move into the cells causing cerebral edema.Etiology · Pathophysiology · Evaluation · Treatment / Management
[52]
SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion)
SIADH causes your body to retain too much water and commonly leads to hyponatremia, which is low levels of sodium in your blood. It's treatable.
[53]
Syndrome of inappropriate antidiuretic hormone secretion
May 12, 2023 · A low blood sodium level is the most common cause of symptoms of too much ADH. It is also the most common clue that a person may have SIADH.
[54]
Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
Symptoms include sluggishness, nausea, muscle weakness, a feeling of imbalance, and confusion. Some people have a history of falls. Diagnosis of SIADH. Blood ...<|separator|>
[55]
The Oxytocin System and Implications for Oxytocin Deficiency in ...
Abstract. Oxytocin (OXT) is a hypothalamic-posterior pituitary hormone with multiple effects, ranging from regulation of energy homeostasis to bone health.Oxytocin: A Pleiotropic... · Oxytocin Deficiency in... · Oxytocin-Deficient State in...
[56]
Hypopituitarism is associated with lower oxytocin concentrations ...
Jun 8, 2017 · Hypopituitarism may therefore be associated with reduced oxytocin concentrations and impaired empathic ability. While further studies are needed ...
[57]
Oxytocin therapy in hypopituitarism: Challenges and opportunities
Dec 2, 2018 · Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that ...PHYSIOLOGICAL EFFECTS · PSYCHOLOGICAL EFFECTS · OXYTOCIN IN...
[58]
Pituitary Tumor Diagnosis: Blood Tests & MRI
An accurate pituitary tumor diagnosis usually involves hormone tests and an MRI scan of the pituitary gland. Hormone Blood Testing to Diagnose Pituitary Tumors.
[59]
Diagnosing Pituitary Tumors - NYU Langone Health
Blood tests help doctors detect many hormonal abnormalities associated with pituitary tumors. For example, a blood test can reveal high levels of the hormone ...Blood Tests · Mri Scans · Venous Blood Sampling
[60]
Pituitary Tumors | Johns Hopkins Medicine
How are pituitary tumors diagnosed? · Blood and urine tests. These tests will check hormone levels in your blood and urine. · CT scan. This test uses X-rays and a ...What You Need To Know · Prolactin-Producing Tumors... · Acth-Producing Tumors
[61]
Pituitary tumors - Diagnosis and treatment - Mayo Clinic
Jun 29, 2024 · MRI scans are used more often than CT scans to detect and diagnose pituitary tumors. But a CT scan may be helpful in planning surgery if your ...Diagnosis · Treatment · Radiation Therapy
[62]
Diagnosis and Treatment of Pituitary Tumors
An MRI can detect the compression of structures surrounding the brain, a potential sign of a pituitary tumor. MRIs are the preferred imaging method because ...How To Diagnose Pituitary... · Pituitary Adenoma Treatment · Drug Therapy
[63]
Tests for pituitary conditions
Name of test: Insulin stress test/Insulin tolerance test. What hormone does it test: Gold Standard to assess pituitary function for cortisol and GH. The ...
[64]
An overview of hypopituitarism - Don't Forget the Bubbles
The insulin tolerance test is the gold standard for diagnosing growth hormone (GH) and adrenocorticotropic hormone (ACTH) deficiencies. After an overnight fast, ...Presentation In The First 28... · Investigating... · 3. Dynamic Hormone Testing
[65]
Endocrine Testing Protocols: Hypothalamic Pituitary Adrenal Axis
Aug 7, 2023 · WHEN TO USE THIS TEST: Patients in whom pituitary or hypothalamic disease may result in impaired corticotroph (or somatotroph) activity.
[66]
Diabetes insipidus - Diagnosis and treatment - Mayo Clinic
Apr 5, 2023 · Tests used to diagnose diabetes insipidus include: Water deprivation test. For this test, you stop drinking fluids for several hours.Missing: stimulation insulin tolerance GH
[67]
Diagnostic Testing for Diabetes Insipidus - Endotext - NCBI Bookshelf
Nov 28, 2022 · The water deprivation test, also known as the indirect water deprivation test should potentially be able to distinguish the various forms of DI.Missing: tolerance | Show results with:tolerance
[68]
Pituitary Tumors Workup - Medscape Reference
Nov 14, 2024 · Visual field testing with static automated perimetry can be used to assess the presence of anterior visual pathway compression by pituitary ...
[69]
Detection of Visual Field Loss in Pituitary Disease - PubMed Central
14 Compression of the chiasm may be symmetrical or asymmetrical relating to the tumour size and its degree of extension involving the chiasm, optic nerve, and ...
[70]
Recent advances in understanding and managing pituitary adenomas
Mar 21, 2023 · Transsphenoidal surgery is the first-line treatment for the majority of PAs, and advances in the field of endoscopic neurosurgery offer ...Missing: disorders | Show results with:disorders
[71]
Consensus guideline for the diagnosis and management of pituitary ...
Feb 9, 2024 · Pituitary surgery for small prolactinomas as an alternative to treatment with dopamine agonists. ... transsphenoidal surgery in Cushing's ...
[72]
Pituitary Tumor Surgery | American Cancer Society
Low hormone levels after surgery can be treated with medicines to replace certain hormones normally made by the pituitary and other glands.Missing: dopamine agonists
[73]
Pituitary Tumors Medication - Medscape Reference
Nov 14, 2024 · These agents are used in the replacement of endogenous growth hormone in patients with adult growth hormone deficiency.
[74]
Pituitary Tumor Symptoms and Treatment - Goodman Campbell
Following surgery or radiation therapy, some hormones may need to be replaced. It is not unusual to need short-term treatment with DDAVP and, at times, long ...
[75]
SIU medical researchers seek causes, solutions for pituitary-related ...
Jan 8, 2024 · Researchers are getting closer and closer to being able to do gene editing so they can fix genetic problems. None of these happen in a ...
[76]
The Evolution of Pituitary Gland Surgery from the Ancients to the ...
Moreover, in his work De Humani Corporis Fabrica, Vesalius drew the pituitary distillation process and illustrated the pituitary stalk, (Figure 1B).
[77]
The History of Acromegaly | Neuroendocrinology - Karger Publishers
Jan 5, 2015 · Pierre Marie coined the term 'acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture.The First Medical Descriptions... · Acromegaly and the Pituitary · Pituitary SurgeryMissing: 1880s | Show results with:1880s
[78]
MEMOIR: Harris' neuroendocrine revolution: of portal vessels and ...
The hypophysial portal vessel system (Fig. 1) is the key to the story. The portal vessels (veins) transport neurohormones from the hypothalamus to the anterior ...
[79]
The Anterior Pituitary Gland | Rudolph's Pediatrics, 23e
It was first used by Galen who named the small outgrowth under the brain αδην (aden), or gland, in his book, written between 161 and 180 A.D., De Usum Partium ( ...
[80]
Hypophysis. From outgrowth, to ocular disorder to pituitary gland
Dear Editor,. In ancient Greek the term ὑπόφυσις meant literally something growing from below, the word being com- posed of the two elements hypo (Greek: ...
[81]
The pituitary gland: a brief history - PubMed
The functions of the pituitary gland as an important constituent of the endocrine system were not understood until the latter part of the nineteenth century.<|control11|><|separator|>
[82]
Functional Pituitary Networks in Vertebrates - Frontiers
The pituitary is a master endocrine gland that developed early in vertebrate evolution and therefore exists in all modern vertebrate classes.
[83]
The orca (Orcinus orca) pituitary gland - PubMed Central - NIH
The pituitary gland is central to endocrine regulation in vertebrates, coordinating key physiological processes such as growth, reproduction, and stress ...
[84]
The Mammalian Pars Intermedia —Structure and Function—
The pars intermedia of the mouse and the rat pituitary consists of 10–15 layers of densely arranged cells separated into lobules by strands of connective ...
[85]
Seasonality of prolactin in birds and mammals - PubMed Central - NIH
Prolactin plays a diverse role in seasonal timing in mammals and birds, though the establishment of seasonal rhythmicity of prolactin differs across taxa.
[86]
Prolactin Mediates Long-Term, Seasonal Rheostatic Regulation of ...
Feb 28, 2024 · Across seasonally breeding animals there is increased secretion of prolactin during periods of breeding and high energy demands. Prior work ...
[87]
Evolution of the regulatory mechanisms for the hypothalamic ...
Review article. Evolution of the regulatory mechanisms for the hypothalamic-pituitary-gonadal axis in vertebrates–hypothesis from a comparative view.
[88]
The neuroendocrine system of invertebrates: a developmental and ...
This review intends to provide a brief overview of invertebrate neuroendocrine systems and to discuss aspects of their development.
[89]
The Endocrinology of Invertebrates - NASA ADS
Neuroendocrine controls exist already in lower invertebrates, and during evolution, endocrine glands have appeared in molluscs, although endocrine cells
[90]
Octopus gonadotrophin-releasing hormone: a multifunctional ...
The optic gland, which is analogous to the anterior pituitary in the context of gonadal maturation, is found on the upper posterior edge of the optic tract ...
[91]
Hormonal Inhibition of Feeding and Death in Octopus - Science
Optic gland secretions may cause death of most cephalopods and may function to control population size.
[92]
Signaling Pathways That Regulate the Crustacean Molting Gland
MIH, produced in the eyestalk X-organ/sinus gland complex, inhibits the synthesis of ecdysteroids. A model for MIH signaling is organized into a cAMP/Ca2+ ...Missing: MH | Show results with:MH
[93]
Crustacean molt-inhibiting hormone: Structure, function, and cellular ...
MIH is produced in a cluster of eyestalk neurosecretory cell soma (the X-organ) and released from their associated axon terminals in the neurohemal sinus gland ...
[94]
Conserved Sensory-Neurosecretory Cell Types in Annelid and Fish ...
Jun 29, 2007 · Neurosecretory control centers form part of the forebrain in many animal phyla, including vertebrates, insects, and annelids.
[95]
Physiological Roles of Serotonin in Bivalves: Possible Interference ...
Feb 24, 2022 · In bivalves, 5-HT is involved in gametogenesis and spawning, oocyte maturation and sperm motility, regulates heart function, gill ciliary beating, mantle/ ...
[96]
Steroid hormones of the octopus self-destruct system - ScienceDirect
Jun 6, 2022 · Lifespan and reproduction are controlled by the principal neuroendocrine center of the octopus: the optic glands, which are functional analogs ...
[97]
Live Fast, Die Young: Grass Fellow Explores Octopus's Death Spiral
Jul 7, 2022 · Previous research has shown that this “death spiral” is controlled by the octopus optic gland, an organ similar to the pituitary gland in ...