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Striatum

The striatum is a key subcortical nucleus of the basal ganglia in the mammalian brain, comprising the dorsal striatum (caudate nucleus and putamen) and the ventral striatum (primarily the nucleus accumbens), which collectively serve as the primary input region for processing cortical and thalamic signals to regulate voluntary movement, reward processing, and habit formation.^[1]^[2] Located deep within the cerebral hemispheres, the striatum receives dense glutamatergic projections from nearly all regions of the neocortex, as well as dopaminergic inputs from the substantia nigra and ventral tegmental area, enabling it to integrate sensory, motor, and motivational information.^[3] Its medium spiny neurons, which constitute about 95% of its neuronal population, form the core of its circuitry, modulating output to downstream basal ganglia structures like the globus pallidus and substantia nigra through direct and indirect pathways that facilitate action selection and suppression.^[4] Functionally, the dorsal striatum is predominantly involved in motor planning, procedural learning, and the execution of habitual behaviors, transforming cortical commands into refined actions via loops with the motor cortex and thalamus.^[5] In contrast, the ventral striatum plays a central role in reward anticipation, motivation, and emotional processing, contributing to reinforcement learning and decision-making through connections with the limbic system and prefrontal cortex.^[6] Dysfunctions in striatal circuitry are implicated in various neurological and psychiatric disorders, including Parkinson's disease, Huntington's disease, addiction, and schizophrenia, underscoring its evolutionary conservation across vertebrates for adaptive behavior.^[7] Recent neuroimaging and optogenetic studies have further elucidated its compartmental organization into striosomes and matrix zones, which differentially influence gene expression and signaling to fine-tune responses to environmental cues.^[8]

Anatomy

Location and Divisions

The striatum forms a principal component of the basal ganglia, positioned deep within the forebrain as a subcortical structure beneath the cerebral cortex, immediately adjacent to the thalamus and the lateral ventricles.^[9] It is anatomically divided into the dorsal striatum, consisting of the caudate nucleus and putamen, and the ventral striatum, encompassing the nucleus accumbens and olfactory tubercle; the dorsal portion occupies a more superior and lateral position, while the ventral division lies inferiorly at the base of the forebrain, with the internal capsule serving as the primary boundary separating the caudate from the putamen. The caudate nucleus adopts a distinctive C-shaped morphology, featuring an anterior head, elongated body along the lateral ventricular wall, and tapering tail that curves posteriorly, whereas the putamen presents a compact, lens-shaped form nestled lateral to the internal capsule and globus pallidus. In human adults, the caudate nucleus measures approximately 6-7 cm³ per hemisphere, with the putamen exhibiting a comparable size of around 6-7 cm³ per hemisphere, varying by sex and population.^[9]^[10]^[11] These major divisions of the striatum demonstrate strong evolutionary conservation across mammalian species, maintaining similar gross anatomical organization from rodents to primates.^[12]

Cellular Composition

The striatum's neuronal population is predominantly composed of medium spiny neurons (MSNs), which account for 75-90% of all striatal neurons in humans and serve as the primary projection neurons.^[13] These MSNs are GABAergic and can be subdivided into two major subtypes based on their expression of dopamine receptors: those expressing D1-like receptors (D1-MSNs), which are part of the direct pathway, and those expressing D2-like receptors (D2-MSNs), which belong to the indirect pathway.^[14] This dichotomy underlies the striatum's role in modulating motor and reward-related functions through differential responses to dopaminergic inputs. The remaining 10-25% of striatal neurons consist of diverse interneurons that provide local inhibition and modulation.^[13] These include cholinergic interneurons, which comprise about 1-2% of the total neuronal population and are tonically active, releasing acetylcholine to regulate MSN excitability.^[15] GABAergic interneurons form the majority of this subclass, encompassing fast-spiking interneurons (FSIs) expressing parvalbumin (approximately 1-3% of neurons), which deliver strong, rapid inhibition to MSNs, and low-threshold spiking interneurons (LTSIs) co-expressing somatostatin and neuropeptide Y (about 1-2% of neurons), which provide more prolonged inhibitory control.^[16] Additionally, calretinin-positive interneurons, a major GABAergic type (roughly 5-10% of neurons), contribute to fine-tuned local circuitry.^[16] Recent transcriptomic studies have identified eight main classes and fourteen subclasses of human striatal interneurons, highlighting greater diversity than in rodents.^[13] Beyond neurons, glial cells form a critical supportive component of the striatal architecture, comprising a substantial portion of the total cellular population—astrocytes alone estimated at 20-40% of brain cells overall, with similar representation in the striatum.^[17] Astrocytes in the striatum exhibit region-specific molecular profiles, such as elevated μ-crystallin expression in ventral areas, and play key roles in maintaining homeostasis by regulating extracellular ion balance, providing metabolic substrates like lactate to energy-demanding MSNs, and modulating synaptic transmission through calcium-dependent gliotransmitter release.^[17] Each striatal astrocyte typically contacts around 11 MSNs and encompasses thousands of synapses, facilitating bidirectional neuron-glia interactions that influence circuit dynamics.^[17] Oligodendrocytes, responsible for myelinating striatal axons, support efficient signal propagation and provide trophic factors to neurons, ensuring structural integrity and responding to pathological changes by promoting remyelination.^[18] The striatum is further organized into neurochemically distinct compartments: striosomes and the surrounding matrix, which together define its functional mosaic. Striosomes occupy 10-15% of the striatal volume, appearing as irregular patches enriched in mu-opioid receptors and substance P, with lower calbindin levels compared to the matrix.^[19] This compartmentalization influences cellular distribution, as striosomes contain a higher density of opioid-sensitive MSNs, while the matrix—making up the bulk of the striatum—hosts more uniformly distributed projection neurons integrated with broader cortical inputs.^[19]

Connectivity

The striatum serves as a key hub in basal ganglia circuitry, receiving convergent afferent inputs that integrate sensory, motor, and cognitive information. The predominant excitatory afferents are glutamatergic projections from the cerebral cortex, forming dense corticostriatal pathways that exhibit topographic organization, with prefrontal areas targeting the ventral striatum and sensorimotor cortices innervating the dorsal regions; these inputs synapse primarily onto spines of medium spiny neurons (MSNs), selectively modulating direct and indirect pathway neurons based on cortical layer and region specificity.^[20]^[21] Dopaminergic afferents originate from the substantia nigra pars compacta (SNc), which projects via the nigrostriatal pathway to the dorsal striatum to regulate motor functions, and from the ventral tegmental area (VTA), which innervates the ventral striatum through the mesolimbic pathway to influence reward processing.^[22]^[23] Serotonergic inputs arise from neurons in the dorsal and median raphe nuclei, providing modulatory projections that interact with dopaminergic terminals to balance striatal excitability and behavioral flexibility.^[24] Efferent outputs from the striatum are predominantly GABAergic and arise from two main populations of MSNs, which comprise over 90% of striatal neurons and express either D1 or D2 dopamine receptors. MSNs of the direct pathway, expressing D1 receptors, project monosynaptically to the internal segment of the globus pallidus (GPi) and the substantia nigra pars reticulata (SNr), disinhibiting thalamocortical circuits to facilitate movement initiation.^[25]^[26] In contrast, MSNs of the indirect pathway, expressing D2 receptors, target the external segment of the globus pallidus (GPe), which in turn influences the subthalamic nucleus and indirect pathway targets, thereby suppressing unwanted movements through increased basal ganglia output inhibition.^[25]^[26] These afferent and efferent connections integrate into parallel cortico-striato-thalamo-cortical loops that segregate functional domains: the sensorimotor loop involves projections from primary motor and somatosensory cortices through the putamen to motor thalamus; the associative loop links prefrontal and parietal cortices via the caudate to cognitive thalamic nuclei; and the limbic loop connects orbitofrontal and anterior cingulate cortices through the nucleus accumbens to limbic thalamic regions, enabling coordinated processing across behavioral modalities.^[27]^[28] Local striatal circuitry further refines signal processing through recurrent axonal collaterals among MSNs, which mediate lateral inhibition to sharpen response selectivity, and through modulatory actions of interneurons, including tonically active cholinergic interneurons that regulate MSN excitability via muscarinic and nicotinic receptors, as well as fast-spiking parvalbumin-positive GABAergic interneurons that provide perisomatic inhibition.^[29]^[30]

Vascular Supply

The striatum receives its primary arterial blood supply from the lenticulostriate arteries, which are small perforating branches arising from the M1 segment of the middle cerebral artery (MCA). These vessels, numbering typically between 2 and 12 with diameters ranging from 80 to 1,400 μm (averaging 100-200 μm), penetrate the anterior perforated substance to irrigate the majority of the dorsal striatum, including the putamen and much of the caudate nucleus. The lateral lenticulostriate arteries predominantly supply the putamen and lateral aspects of the caudate, while the medial branches target the medial caudate and adjacent structures; limited anastomoses exist between these territories, providing some redundancy but overall sparse collateral circulation.^[31]^[32]^[33] Additional supply to specific regions comes from the recurrent artery of Heubner, a medial striate artery originating from the anterior cerebral artery (ACA), which vascularizes the anterior head and body of the caudate nucleus as well as the anterior inferior internal capsule. The posterior portions of the striatum, particularly the tail of the caudate and lower globus pallidus, are supplied by branches of the anterior choroidal artery, which arises from the internal carotid artery and courses along the optic tract. These complementary arterial inputs ensure comprehensive coverage of the striatal subregions, though the small caliber of the perforators limits robust interconnections.^[33]^[34]^[35] Venous drainage of the striatum primarily occurs via the thalamostriate vein (also known as the vena terminalis), which collects blood from the caudate nucleus and adjacent thalamic regions before joining the internal cerebral vein to form the great cerebral vein of Galen. Superior lenticular veins from the putamen and globus pallidus converge into this system, facilitating efficient outflow toward the dural sinuses. The deep venous architecture mirrors the arterial end-artery pattern, contributing to regional vulnerability.^[36]^[37] Due to the small vessel diameters and lack of significant collaterals, the striatal vascular territory is particularly susceptible to lacunar infarcts from occlusion of single perforating arteries, often resulting from lipohyalinosis or microatheroma in small vessel disease. Such infarcts, typically under 15 mm in diameter, can disrupt striatal perfusion without widespread hemispheric involvement.^[31]^[32]

Development

Embryonic Origins

The striatum primarily derives from progenitor cells in the lateral ganglionic eminence (LGE), a transient proliferative structure in the ventral telencephalon that emerges during early embryonic development. In humans, the LGE forms around gestational weeks 5-6, coinciding with the initial patterning of the subpallium, while in mice, the LGE becomes morphologically distinct by embryonic day (E) 11, marking the onset of striatal specification. Initial neurogenesis in the LGE begins by E12.5 in mice, equivalent to approximately week 7 of human gestation, generating the first cohorts of striatal projection neurons.^[38]^[39]^[40] Specification of LGE progenitors relies on critical transcription factors that orchestrate regional identity and neuronal fate. The homeobox gene Gsh2 plays a pivotal role in progenitor proliferation and patterning within the LGE, ensuring proper histogenesis of striatal and olfactory bulb structures; mutants exhibit severe reductions in LGE-derived neurons. Similarly, Dlx1 and Dlx2 are essential for promoting the GABAergic phenotype in nascent striatal neurons, particularly medium spiny neurons (MSNs), by regulating downstream genes involved in differentiation and migration. These factors act in a hierarchical manner, with Gsh2 upstream influencing Dlx expression to refine ventral telencephalic identities.^[41]^[42]^[43]^[44] Following their generation in the LGE ventricular zone, MSNs migrate to form the nascent striatum through a combination of radial and tangential pathways. Radial migration predominates, with newborn neurons ascending along radial glial scaffolds from the LGE to populate the striatal mantle; this process establishes the basic laminar organization. Tangential migration, involving lateral movements within the intermediate zone, contributes to the intermixing of MSN subtypes, such as direct- and indirect-pathway neurons, enhancing striatal mosaicism. By E15.5 in mice, these migratory dynamics culminate in the compartmentalization of the striatum into striosome (patch) and matrix domains, reflecting differential birth dates and molecular signatures of progenitors.^[45]^[46]^[47]

Postnatal Maturation

The postnatal maturation of the striatum involves extensive synaptic refinement, neurotransmitter system development, and integration of environmental influences to establish functional circuits essential for motor, reward, and cognitive processes. Synaptogenesis in the human striatum, as in other brain regions, peaks during the first two years of life, with rapid formation of excitatory and inhibitory synapses on medium spiny neurons driven by glutamatergic inputs from the cortex and thalamus. This overproduction of synapses reaches a maximum in early postnatal life before stabilizing through selective elimination. Synaptic pruning then predominates during adolescence, reducing connectivity in striatal regions to enhance circuit efficiency and specificity, a process guided by activity-dependent mechanisms.^[48] The dopamine system undergoes critical postnatal tuning, with midbrain-derived innervation of the striatum largely established prenatally by mid-gestation, followed by functional maturation involving increasing dopamine release and receptor density, particularly D1 and D2 subtypes on direct and indirect pathway neurons, which refines circuit tuning for reward processing and motor control.^[49] In rodents, dopamine neurotransmission ramps up from the first to third postnatal week, preceding spiny projection neuron maturation and influencing synaptic strengthening in the direct pathway.^[50] These changes continue through adolescence in humans, with striatal dopamine signaling specializing regionally to support behavioral transitions.^[51] Experience-dependent plasticity plays a key role in shaping corticostriatal connections during early postnatal periods, where sensory inputs from the environment modulate synaptic strength and dendritic arborization in striatal neurons.^[52] Early sensory experiences, such as tactile or auditory stimuli, drive long-term potentiation at corticostriatal synapses, refining projections from sensorimotor and associative cortices to match behavioral demands.^[53] This plasticity is particularly pronounced in the first few years, when thalamic and cortical afferents integrate sensory information to stabilize striatal maps.^[54] Adolescence represents a critical period for striatal maturation, particularly for habit formation, as enhanced dopamine signaling shifts behaviors from goal-directed to habitual actions via strengthened indirect pathway circuits.^[55] During this window, typically ages 10-20, synaptic pruning and myelination optimize corticostriatal loops, making the system more responsive to reinforcement learning.^[48] Sex differences emerge, with females exhibiting earlier striatal volume peaks (around 12 years) compared to males (around 15 years), potentially contributing to divergent timelines in habit consolidation and reward sensitivity.^[56]

Functions

Motor Control

The striatum plays a pivotal role in motor control through its integration into the basal ganglia-thalamocortical circuits, where it modulates the initiation and execution of voluntary movements. Medium spiny neurons (MSNs) in the striatum, which constitute the primary output neurons, are segregated into two major pathways based on their dopamine receptor expression and projections. This organization allows the striatum to balance facilitation and suppression of motor actions, ensuring precise action selection and suppression of competing movements.^[57] The direct pathway, comprising D1 receptor-expressing MSNs (D1-MSNs), promotes movement by projecting directly to the internal segment of the globus pallidus (GPi) and substantia nigra pars reticulata (SNr), the output nuclei of the basal ganglia. Activation of D1-MSNs inhibits these output structures, leading to disinhibition of thalamocortical projections to motor areas in the cortex, thereby facilitating the selected movement. This pathway is essential for the initiation and vigor of voluntary actions, as demonstrated in optogenetic studies where selective stimulation of D1-MSNs accelerates motor responses and enhances movement execution.^[58]^[59] In contrast, the indirect pathway, formed by D2 receptor-expressing MSNs (D2-MSNs), inhibits inappropriate or unwanted movements by projecting to the external segment of the globus pallidus (GPe). D2-MSN activation inhibits the GPe, leading to disinhibition of the subthalamic nucleus (STN), which in turn excites the GPi/SNr, ultimately increasing inhibitory output from the GPi/SNr to the thalamus and suppressing motor activity. This pathway refines motor control by preventing extraneous actions, with electrophysiological evidence showing that D2-MSN activity correlates with the suppression of competing motor programs during task performance.^[57]^[60]^[61] A key aspect of striatal motor function is the sensorimotor loop, which integrates inputs from cortical motor and somatosensory areas primarily through the putamen, the dorsal striatal region dominant in motor processing. This loop allows the striatum to process sensory feedback alongside motor commands, enabling adaptive adjustments during movement execution, such as in sequential tasks where putaminal activity modulates the scaling of motor output based on sensory cues.^[62]^[63]^[1] The striatum's role in action selection is captured by the Go/No-Go model, in which the direct pathway signals "Go" for desired actions and the indirect pathway signals "No-Go" to veto alternatives. Dopaminergic inputs from the substantia nigra bias this selection by exciting D1-MSNs and inhibiting D2-MSNs, thereby promoting the execution of contextually appropriate movements while suppressing others, as evidenced in computational models and in vivo recordings during decision-making tasks.^[64]^[65]^[66]

Reward Processing

The ventral striatum, particularly the nucleus accumbens, serves as a core structure for distinguishing between hedonic "liking"—the sensory pleasure derived from rewards—and motivational "wanting"—the incentive drive to pursue them. Hedonic hotspots, localized in the medial shell of the nucleus accumbens, are discrete sites where μ-opioid receptor stimulation amplifies the affective "liking" reactions to palatable rewards, such as enhanced facial expressions of pleasure in response to sweetness in animal models. These hotspots interact with similar opioid-sensitive regions in the ventral pallidum to generate the core hedonic impact of rewards. In contrast, "wanting" is primarily driven by mesolimbic dopamine projections to the nucleus accumbens shell, which enhance the incentive salience of reward cues, motivating approach behaviors without necessarily altering the sensory pleasure itself.^[67]^[68]^[68] Dopamine signaling in the striatum is pivotal for reward prediction and learning, with phasic bursts from midbrain neurons encoding reward prediction errors (RPEs) that update value expectations. These RPEs reflect discrepancies between anticipated and actual rewards, as demonstrated in seminal electrophysiological recordings where dopamine neurons respond tonically to unexpected rewards and phasically to cues predicting them after learning. This process is formalized in temporal difference (TD) learning models, where the RPE is computed as

\delta = r + \gamma V(s') - V(s)

with \delta denoting the prediction error, r the immediate reward, \gamma the discount factor for future rewards, V(s) the value of the current state s, and V(s') the value of the next state s'. In the striatum, these dopamine signals arrive via the nigrostriatal and mesolimbic pathways, enabling medium spiny neurons—primarily expressing D1 or D2 dopamine receptors—to adjust synaptic weights and refine reward associations.^[69]^[70] The striatum integrates reward information through corticostriatal-limbic circuits, where inputs from the amygdala and orbitofrontal cortex (OFC) contribute to value encoding. Basolateral amygdala projections convey emotional and associative value signals to the ventral striatum, facilitating the representation of reward outcomes in decision-making contexts. Similarly, OFC inputs provide abstract representations of reward magnitude and probability, which ventral striatal neurons encode as the specific value of selected actions during goal-directed choices. This convergence allows the striatum to compute integrated value signals that guide reinforcement learning.^[71]^[72]^[72] Through TD learning mechanisms, the striatum updates reward expectations based on outcome discrepancies, with dopamine RPEs serving as the primary teaching signal. Ventral striatal circuits act as a critic in reinforcement learning, propagating TD errors to adjust predictive values over time, as evidenced by neural activity patterns that shift from immediate rewards to anticipatory cues during Pavlovian conditioning. This iterative process enables the striatum to optimize behavior by refining predictions of future rewards across extended timescales.^[70]

Cognitive and Habitual Behaviors

The dorsal striatum plays a pivotal role in distinguishing between goal-directed actions, which are flexible and outcome-sensitive, and habitual actions, which are automatic and stimulus-response driven. In humans and rodents, the dorsomedial striatum, including the caudate nucleus, supports goal-directed behavior by integrating action-outcome contingencies, allowing for adaptive decision-making based on changing environmental rewards.^[73] In contrast, the dorsolateral striatum, encompassing the putamen, facilitates the formation of habits through stimulus-response associations, enabling efficient, overlearned behaviors that operate independently of outcomes.^[73] This functional dissociation is evidenced by neuroimaging studies showing caudate activation during tasks requiring sensitivity to action values, while putamen activity increases with habitual responding.^[74] The associative striatum, particularly the caudate, forms part of a cortico-striatal loop that integrates with the prefrontal cortex to underpin working memory and planning. This loop enables the maintenance and manipulation of goal-relevant information, supporting cognitive flexibility in complex decision-making scenarios.^[75] Projections from the dorsolateral prefrontal cortex to the caudate modulate attentional control and executive functions, allowing individuals to prioritize and sequence cognitive operations for prospective planning.^[76] Functional MRI evidence demonstrates that disruptions in this prefrontal-striatal connectivity impair working memory performance, highlighting the striatum's role in bridging sensory inputs with executive outputs.^[75] In procedural learning, the dorsolateral striatum contributes to the chunking of action sequences, transforming discrete movements into fluid, integrated behaviors. This process involves grouping individual actions into larger units, which facilitates the efficient execution of learned routines, such as motor skills or cognitive procedures.^[77] Electrophysiological recordings in rodents reveal that dorsolateral striatal neurons encode sequence boundaries and transitions, promoting the consolidation of chunks during overtraining.^[78] Human studies corroborate this, showing increased putamen activity when participants automate sequential tasks, reducing cognitive load for habitual performance.^[79] Normal variations in striatal function contribute to individual differences in compulsive tendencies, akin to milder forms of OCD-like behaviors in healthy populations. Stronger habitual control via the dorsolateral striatum correlates with repetitive checking or ordering behaviors in non-clinical samples, reflecting an adaptive but sometimes rigid reliance on routines.^[80] These variations are linked to transdiagnostic traits of compulsivity, where enhanced striatal habit circuits predict greater persistence in goal-irrelevant actions under uncertainty.^[81] Such findings suggest that the striatum's balance between flexibility and automation underlies subclinical compulsions, without implying pathology.^[80]

Clinical Significance

Movement Disorders

The striatum plays a central role in movement disorders, where dysfunction in its neural circuits leads to characteristic motor impairments. In Parkinson's disease, progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta results in dopamine depletion primarily in the dorsal striatum, which underlies key motor symptoms such as bradykinesia and rigidity.^[82] This depletion disrupts the balance between the direct and indirect pathways in the basal ganglia, reducing excitatory drive to thalamocortical motor circuits and contributing to hypokinetic features.^[83] Additionally, alpha-synuclein aggregates and dystrophic neurites are observed in the striatum, particularly in medium spiny neurons (MSNs), exacerbating neuronal dysfunction and synaptic loss in advanced stages.^[84] Huntington's disease, an autosomal dominant neurodegenerative disorder, arises from an expanded CAG trinucleotide repeat in the huntingtin gene (HTT) on chromosome 4, leading to a toxic gain-of-function in the mutant huntingtin protein.^[85] This mutation causes progressive striatal atrophy, particularly in the caudate nucleus and putamen, manifesting as hyperkinetic choreiform movements due to impaired motor inhibition.^[86] Neuropathologically, there is selective vulnerability and loss of MSNs, with those in the indirect pathway (expressing D2 dopamine receptors and projecting to the globus pallidus externa) degenerating earlier and more severely than direct pathway MSNs, resulting in disinhibition of thalamocortical outputs and involuntary movements.^[87] Dystonia involves abnormal sustained muscle contractions leading to twisted postures, often linked to striatal circuit imbalances. In primary dystonias, such as DYT1-TOR1A, a GAG deletion mutation in the TOR1A gene encoding torsinA disrupts protein folding and endoplasmic reticulum function, altering the direct-indirect pathway equilibrium in the striatum toward excessive direct pathway activity and reduced surround inhibition.^[88] Similarly, Tourette's syndrome features tics arising from striatal hyperactivity, with genetic factors contributing to an imbalance favoring the direct pathway over the indirect, as evidenced by reduced striatal GABAergic interneuron density and dysregulated dopamine modulation in affected individuals.^[89] Therapeutic interventions targeting striatal outputs have shown efficacy in managing these disorders. Deep brain stimulation (DBS) of the subthalamic nucleus normalizes excessive beta oscillations and modulates downstream basal ganglia circuits, including striatal projections, thereby alleviating bradykinesia and rigidity in Parkinson's disease by enhancing thalamocortical drive without directly stimulating the striatum.^[90] In dystonia and Huntington's, STN-DBS similarly influences striatal outflow via the hyperdirect pathway, reducing hyperkinetic symptoms by restoring inhibitory balance in the indirect pathway.^[91]

Neuropsychiatric Disorders

The striatum plays a critical role in the pathophysiology of several neuropsychiatric disorders, particularly through its involvement in dopaminergic signaling, reward processing, and cortico-striatal circuits that modulate cognition and emotion. In schizophrenia, excessive dopamine release in the ventral striatum, part of the mesolimbic pathway, is implicated in the emergence of positive symptoms such as delusions and hallucinations, as evidenced by positron emission tomography studies showing elevated striatal dopamine synthesis capacity in patients during acute psychotic episodes.^[92] This hyperdopaminergia disrupts the balance of striatal subregions, leading to aberrant salience attribution where neutral stimuli are perceived as overly significant. Conversely, negative symptoms like avolition and blunted affect are associated with hypofrontality in prefrontal-striatal circuits, particularly involving the associative striatum (dorsomedial caudate and putamen), where reduced dopaminergic modulation impairs executive function and motivation, as demonstrated in functional neuroimaging of medicated and unmedicated patients.^[93]^[94] In bipolar disorder, striatal dysregulation manifests differently across mood states, with hyperactivity in the ventral striatum during manic phases contributing to elevated reward sensitivity and impulsivity. Functional magnetic resonance imaging (fMRI) studies reveal increased ventral striatal activation in response to reward cues in individuals with bipolar I disorder experiencing mania, correlating with symptom severity on scales like the Young Mania Rating Scale.^[95] This hyperactivity may stem from enhanced dopaminergic transmission in the nucleus accumbens, exacerbating goal-directed behaviors and risk-taking. Structurally, volumetric reductions in the caudate nucleus are consistently observed in bipolar patients, independent of mood state, with meta-analyses indicating smaller caudate volumes bilaterally compared to healthy controls, potentially reflecting trait-related neurodevelopmental alterations that predispose to mood instability.^[96]^[97] Autism spectrum disorder (ASD) involves early striatal abnormalities that align with core behavioral features, including repetitive behaviors. Longitudinal MRI studies show caudate nucleus enlargement in toddlers with ASD as young as 2-3 years old, with this volumetric increase persisting and correlating with the severity of restricted and repetitive behaviors (RRBs) measured by the Repetitive Behavior Scale-Revised.^[98]^[99] Such enlargement, often disproportionate to overall brain growth, implicates disrupted striatal development in ritualistic patterns. Furthermore, altered corticostriatal connectivity underlies these traits, with fMRI evidence of precocious maturation and hyperactivity in circuits linking the prefrontal cortex to the dorsal striatum in preschool-aged children with ASD, leading to inflexible habit formation and sensory sensitivities.^[100]^[101] Recent research since 2020 highlights the striatum's role in social cognition deficits across neuropsychiatric conditions, particularly through disruptions in nucleus accumbens-orbitofrontal cortex connectivity. In schizophrenia and ASD, reduced functional coupling between the nucleus accumbens and orbitofrontal regions impairs social reward processing, as shown in resting-state fMRI studies where lower connectivity predicts deficits in theory of mind tasks and social withdrawal.^[102] Similar orbitofrontal-striatal dysconnectivity in bipolar disorder during euthymic phases contributes to impaired emotion recognition, with volumetric reductions in the nucleus accumbens mediating social functioning impairments in large cohort analyses.^[103] These findings underscore shared striatal mechanisms in social deficits, suggesting potential targets for circuit-based interventions like transcranial magnetic stimulation.^[104]

Addiction and Reward Dysregulation

The striatum, particularly its ventral portion encompassing the nucleus accumbens, plays a pivotal role in addiction through dysregulation of the mesolimbic dopamine pathway. Drugs of abuse, such as cocaine, hijack this pathway by blocking dopamine transporters, thereby elevating extracellular dopamine levels in the nucleus accumbens and producing intense euphoria.^[105] This acute surge reinforces drug-seeking behavior via enhanced reward signaling, but chronic exposure leads to tolerance, where higher doses are required to achieve the same effect due to diminished dopamine responsiveness.^[106] Withdrawal from these substances then manifests as dysphoria and anhedonia, driven by depleted dopamine transmission in the same circuit, perpetuating the addiction cycle.^[107] In the progression of addiction, there is a notable shift from ventral to dorsal striatum involvement, transforming initially goal-directed drug use into compulsive, habitual seeking. Early drug consumption is mediated by the ventral striatum's sensitivity to reward cues, but with prolonged use, control transfers to the dorsal striatum, where inflexible habits dominate behavior despite negative consequences.^[108] This transition promotes persistent drug-seeking even in the face of adverse outcomes, as dorsal striatal circuits prioritize automatic responses over flexible decision-making.^[109] Key neuroadaptations in the striatum underlie these changes, including downregulation of dopamine D2 receptors, which reduces inhibitory control over reward circuits and heightens vulnerability to relapse.^[110] In medium spiny neurons, epigenetic modifications such as the accumulation of ΔFosB—a stable transcription factor induced by repeated drug exposure—persistently alter gene expression to enhance sensitivity to drug-related cues and reinforce addictive behaviors.^[111] This ΔFosB buildup occurs selectively in D1-type medium spiny neurons of the nucleus accumbens, driving long-term plasticity that sustains addiction.^[112] Behavioral addictions, such as pathological gambling, exhibit analogous dysregulation without pharmacological agents, characterized by ventral striatal hypersensitivity to reward anticipation and cues.^[113] In gamblers, this manifests as exaggerated dopamine responses in the nucleus accumbens during monetary wins or near-misses, mirroring substance-induced changes and fostering compulsive engagement.^[114] Such hypersensitivity disrupts normal reward prediction error signaling in the striatum, amplifying the motivational pull of the behavior.^[115]

History and Comparative Aspects

Historical Discoveries

The striatum, a key component of the basal ganglia, was first described in the 17th century by English physician and anatomist Thomas Willis in his seminal work Cerebri anatome published in 1664, where he referred to it as the "corpus striatum" due to its striped appearance from myelinated fibers.^[116] Willis's detailed illustrations and observations laid foundational groundwork for understanding subcortical structures, emphasizing their role in neural connectivity.^[117] In the late 18th century, French anatomist Félix Vicq d'Azyr advanced this knowledge through his Traité d'anatomie et de physiologie (1786), in which he distinguished and named the caudate nucleus and putamen as separate components of the striatum, providing clearer delineations via anatomical plates.^[118] This nomenclature clarified the striatum's internal organization, facilitating subsequent studies on its boundaries and relations to surrounding white matter tracts.^[119] The 19th century saw further integration of the striatum into broader basal ganglia concepts, with Austrian neurologist Theodor Meynert contributing to the integration of the striatum into broader basal ganglia concepts in the 19th century. Concurrently, British physician James Parkinson's 1817 essay An Essay on the Shaking Palsy provided the earliest clinical description of what became known as Parkinson's disease, noting involuntary tremors and rigidity later associated with striatal dysfunction, though without direct anatomical correlation at the time.^[120] The 20th century brought neurochemical insights, particularly through Swedish pharmacologist Arvid Carlsson's 1950s experiments demonstrating dopamine as a neurotransmitter in the brain, including its high concentrations in the striatum, which earned him the Nobel Prize in Physiology or Medicine in 2000.^[121] This discovery illuminated the nigrostriatal dopamine pathway's importance in motor control. Building on this, in the 1980s, researchers Roger Albin, Anne Young, and Mahlon DeLong proposed the direct and indirect pathway model of basal ganglia circuitry, positing that striatal medium spiny neurons modulate thalamic output via D1- and D2-dopamine receptor pathways to facilitate or inhibit movement.^[122] From the 1990s onward, functional magnetic resonance imaging (fMRI) advancements enabled non-invasive mapping of striatal activity, revealing its functional subdivisions such as sensorimotor, associative, and limbic regions through task-based and resting-state studies.^[123] These techniques confirmed heterogeneous activation patterns, linking ventral striatum to reward and dorsal regions to cognition, thus refining historical anatomical views with dynamic evidence. In the 2010s, optogenetic studies validated the direct and indirect pathway model across species, while as of 2025, advanced neuroimaging techniques continue to refine striatal functional mapping.^[124]^[125]

Striatum in Non-Human Animals

The striatum exhibits a high degree of homology across vertebrates, serving as a core component of the basal ganglia circuitry involved in action selection and motor control. This conservation is evident from lampreys to mammals, where the striatum receives inputs from pallial (cortical-like) structures and projects to pallidal regions, maintaining fundamental topological organization despite variations in brain size and complexity.^[126] In non-mammalian vertebrates such as fish, the basal ganglia, including striatal analogs, facilitate basic action selection during behaviors like prey capture and escape responses, as demonstrated in zebrafish models where optogenetic manipulation of striatal pathways modulates decision-making in dynamic environments.^[127] Similarly, in avian species like songbirds, the striatum's analog—known as Area X within the anterior forebrain pathway—plays a critical role in vocal learning, integrating sensory feedback to refine song production through reinforcement mechanisms akin to mammalian reward processing.^[128] Evolutionary trends show increased striatal compartmentalization in mammals, with distinct striosome and matrix domains emerging alongside cortical expansion to support more sophisticated behavioral integration. This compartmentalization, which emerges in mammals alongside the phylogenetic development of the cerebral cortex, allows for segregated processing of motivational and sensorimotor signals, enhancing adaptive responses.^[129] In rodents, a key model for striatal research, the nucleus accumbens shell within the ventral striatum is prominently involved in reward processing, encoding hedonic value and motivating approach behaviors; optogenetic studies from the 2010s have elucidated direct and indirect pathway dynamics, revealing how D1- and D2-receptor expressing medium spiny neurons differentially gate reward-seeking versus aversion.^[130] These rodent models highlight the striatum's role in habit formation and reinforcement learning, with the shell's medial-lateral gradients tuning sensitivity to natural and drug rewards.^[131] Comparative analyses reveal expansions in the striatum across primates relative to rodents, particularly in associative domains linked to cognitive functions. While rodents exhibit a more compact dorsomedial associative striatum for prelimbic cortical integration, primates display proportionally larger caudate and putamen regions, supporting enhanced executive control and social cognition; these human-specific enlargements build upon conserved vertebrate blueprints.^[132]^[133]

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Jul 21, 2009 · The striatum is the main input nucleus of the basal ganglia and a key neural substrate for procedural learning and memory. The vast majority ...
[5]
The Striatum: Where Skills and Habits Meet - PMC - PubMed Central
We review the evidence supporting the role of the striatum in optimizing behavior by refining action selection and in shaping habits and skills.
[6]
Neuroanatomy of Reward: A View from the Ventral Striatum - NCBI
In summary, projections from frontal cortex form a functional gradient of inputs from the ventromedial to the dorsolateral striatum, with the medial and ...<|control11|><|separator|>
[7]
[PDF] The role of the striatum in social behavior - Frontiers
ANATOMY AND NEUROPHYSIOLOGY OF THE STRIATUM The striatum is the input module to the basal ganglia, a neuronal circuit necessary for voluntary movement control ...
[8]
[PDF] The striatal compartments, striosome and matrix, are ... - bioRxiv
Dec 17, 2024 · The striatum is divided into two interdigitated tissue compartments, the striosome and matrix. 12 These compartments exhibit distinct ...<|separator|>
[9]
Neuroanatomy, Basal Ganglia - StatPearls - NCBI Bookshelf
Of the dorsal striatum, the caudate nucleus is a C-shaped structure comprising a head, body, and tail located lateral to the lateral ventricles. The lenticular ...
[10]
KoreaMed Synapse
Jan 20, 2016 · The average caudate volume was 7.23±1.18 cm3 in male group and 6.23±0.96 cm3 in female group. The average volume of putamen was 7.19±1.25 cm3 ...
[11]
Morphometric and volumetric study of caudate and putamen nuclei ...
The aim of this study was to determine age, gender, and hemispheric differences in the volume of the human neostriatum (striatum) nucleus in healthy humans.
[12]
Evolutionary Conservation of the Basal Ganglia as a Common ...
Jul 12, 2011 · These results show that the detailed basal ganglia circuitry is present in the phylogenetically oldest vertebrates and has been conserved.Missing: divisions | Show results with:divisions
[13]
The microcircuits of striatum in silico - PNAS
It consists of two types of projection neurons, together representing 95% of the neurons, and 5% of interneurons, among which are the cholinergic, fast-spiking, ...
[14]
Striatal Neurons Expressing D1 and D2 Receptors are ... - Nature
Jan 27, 2017 · Our data indicate that D 1 /D 2 MSNs in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation.
[15]
Striatal cholinergic interneuron regulation and circuit effects - PMC
These locally projecting inhibitory cells consist of three types: parvalbumin-expressing fast spiking interneurons (FSIs), NPY/SOM/NOS-expressing persistent ...
[16]
Heterogeneity and Diversity of Striatal GABAergic Interneurons - PMC
All striatal PV+ interneurons are classified electrophysiologically as fast-spiking interneurons (FSI) and in some instances can fire at frequencies over 400 Hz ...
[17]
Astrocyte–Neuron Interactions in the Striatum: Insights on Identity ...
Jul 24, 2019 · The finding that striatal astrocytes are proximate to many MSN somata suggests that they regulate the extracellular milieu, as suggested by ...
[18]
Astrocyte-oligodendrocyte interaction regulates central nervous ...
Jun 8, 2023 · We show that interaction between glial cells – astrocytes and mature myelin-forming oligodendrocytes – is a determinant of remyelination.
[19]
The Striosome and Matrix Compartments of the Striatum
Dec 1, 2016 · Here, we review recent findings that suggest there can be distinct regulation of neural function in striosome versus matrix compartments.
[20]
Cortical and Thalamic Innervation of Direct and Indirect Pathway ...
Nov 3, 2010 · The striatum receives major excitatory inputs from the cortex and thalamus that predominantly target the spines of medium-sized spiny ...
[21]
A comprehensive excitatory input map of the striatum reveals ... - eLife
Nov 28, 2016 · This study presents a comprehensive map of the excitatory inputs to the mouse striatum. The input patterns reveal boundaries between the known striatal domains.<|control11|><|separator|>
[22]
The Formation and Function of the VTA Dopamine System - PMC
Mar 30, 2024 · Dopamine neurons in the SNc mostly project to the dorsal striatum through the nigrostriatal pathway and regulate voluntary movement [2].
[23]
The dopamine neuron synaptic map in the striatum - ScienceDirect
Mar 28, 2023 · Dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster ...
[24]
Computational studies of the role of serotonin in the basal ganglia
There are dense 5-HT projections to the striatum from the dorsal raphe nucleus and it is known that increased 5-HT in the striatum facilitates DA release from ...
[25]
Control of Basal Ganglia Output by Direct and Indirect Pathway ...
Nov 20, 2013 · The direct and indirect efferent pathways from striatum ultimately reconverge to influence basal ganglia output nuclei, which in turn ...
[26]
Segregation of D1 and D2 dopamine receptors in the striatal direct ...
The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these ...
[27]
The mouse cortico–basal ganglia–thalamic network | Nature
Oct 6, 2021 · The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and ...
[28]
Cortico-Striatal-Thalamic Loop Circuits of the Salience Network
The SN's cortico-striato-thalamo-cortical loop increasingly appears to be central to mechanisms of cognitive control, as well as to a broad spectrum of ...Introduction · Anatomy and Function of the... · Abnormalities of SN-CSTC...
[29]
Striatal local circuitry: a new framework for lateral inhibition - PMC
The local connectivity is mediated by the striatal interneurons and by the synapses formed by collateral axons of SPNs that linger within the striatum and ...
[30]
Striatal cholinergic interneuron regulation and circuit effects - Frontiers
The striatum has the highest levels of cholinergic markers in the brain, including ACh, choline acetyltransferase (ChAT), and acetylcholinesterase (AChE) ( ...
[31]
Anatomy, Head and Neck, Striate Arteries - StatPearls - NCBI - NIH
Aug 9, 2025 · These vessels supply the subcortical structures of the central nervous system. The lenticulostriate arteries (LSAs) branch from the MCA, a ...Structure and Function · Blood Supply and Lymphatics · Surgical Considerations
[32]
Anatomic and clinical correlations of the lenticulostriate arteries
The lenticulostriate arteries ranged between two and 12 in number, and from 80 microm to 1,400 microm in size. They originated from the main trunk, terminal ...
[33]
Neuroanatomy Online: Lab 4 (ƒ3) - The Ventricles and Blood Supply
... arteries or lenticulostriate arteries. These deep vessels supply most of the lateral areas of the corpus striatum of the basal ganglia and the internal capsule.<|control11|><|separator|>
[34]
Neuroanatomy, Nucleus Caudate - StatPearls - NCBI Bookshelf
Jul 24, 2023 · The caudate nucleus receives blood supply from the anterior cerebral artery, middle cerebral artery, and anterior choroidal artery. The ...
[35]
Neuroanatomy, Globus Pallidus - StatPearls - NCBI Bookshelf
The GP receives its blood supply from the anterior choroidal artery (AChA), middle cerebral artery (MCA), and anterior cerebral artery (ACA). The MCA ...Neuroanatomy, Globus... · Structure And Function · Review Questions<|separator|>
[36]
The cerebral circulation and cerebrovascular disease I: Anatomy
The septal veins receive blood from the septum pellucidum and corpus callosum. The thalamostriate veins receive blood from the longitudinal caudate veins. The ...Anterior Cerebral Artery · Middle Cerebral Artery · The Cerebral Venous System<|control11|><|separator|>
[37]
[Venous vascularization of the lentiform nucleus] - PubMed
The first one is formed by superior lenticular veins which drain into the thalamo-striate vein, principal tributary of the internal cerebral vein. The ...
[38]
Origin and Molecular Specification of Striatal Interneurons
Aug 15, 2000 · The basal ganglia (striatum and pallidum) derive from both the lateral and the medial ganglionic eminences in the telencephalon (LGE and MGE, ...
[39]
From Progenitors to Progeny: Shaping Striatal Circuit Development ...
The formation of the LGE as a clearly visible structure in the subpallium occurs around E11 in mice and is followed by the onset of neurogenesis by a diverse ...Missing: timeline | Show results with:timeline
[40]
Normal and abnormal appearance of fetal ganglionic eminence on ...
Apr 26, 2023 · The fetal GE increases in size during early pregnancy, reaching its maximum dimension around 20 weeks of gestation, after which it progressively ...
[41]
Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 ...
Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons ...Missing: embryonic origins Dlx1/
[42]
A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 ...
Dec 1, 2001 · Previous studies have shown that Gsh2–/– embryos suffer from an early misspecification of precursors in the lateral ganglionic eminence (LGE) ...
[43]
Ganglionic Eminence - an overview | ScienceDirect Topics
Mice containing compound Dlx1/Dlx2 mutations die at birth and have a severe reduction in the tangential migration of interneurons from the ventral eminences to ...
[44]
Dlx1/2-dependent expression of Meis2 promotes neuronal fate ...
Both cell types originate from a common pool of progenitor cells located in the lateral ganglionic eminence (LGE) and express TFs such as Gsx1/2, Ascl1 and Dlx1 ...
[45]
Identification of Two Distinct Progenitor Populations in the Lateral ...
Jan 1, 2003 · Recent studies have shown that both radial and tangential migration contributes significantly to neuronal diversity within distinct ...
[46]
Active intermixing of indirect and direct neurons builds the striatal ...
Nov 9, 2018 · Thus, in contrast to the assumption that SPN only migrate radially, iSPN undergo a tangential migration within the striatum and intermix with ...
[47]
Ctip2 Controls the Differentiation of Medium Spiny Neurons and the ...
Jan 16, 2008 · Ctip2 is a critical regulator of MSN differentiation, striatal patch development, and the establishment of the cellular architecture of the striatum.Striatal Ctip2 Expression Is... · Absence Of Ctip2 Impairs The... · Failure Of Striatal Patch...Missing: composition | Show results with:composition
[48]
Pruning recurrent neural networks replicates adolescent changes in ...
May 27, 2022 · Estimates suggest that up to 40% of excitatory synapses are pruned in prefrontal cortex, between the ages of 10 and 30 (13). Studies also ...
[49]
Developmental origins of brain disorders: roles for dopamine
Human DAergic innervation occurs early in development and is strongly established by mid-gestation (Olson et al., 1973; Verney et al., 1991, 1993; Zecevic and ...
[50]
Maturation of the human striatal dopamine system revealed by PET ...
Feb 12, 2020 · Our results provide new evidence for maturational specialization of the striatal DA system through adolescence.Missing: synaptogenesis | Show results with:synaptogenesis
[51]
Dopamine Triggers the Maturation of Striatal Spiny Projection ...
We found that dopamine neuro-transmission increases from the first to the third postnatal week in mice and precedes the reduction in spiny projection neuron ( ...
[52]
Early sensory experience influences the development of ...
We show that multisensory thalamocortical connections emerge before corticocortical connections but mostly disappear during development.
[53]
Bidirectional Activity-Dependent Plasticity at Corticostriatal Synapses
Dec 7, 2005 · Despite the importance of corticostriatal connections in sensorimotor learning and cognitive functions, plasticity forms at these synapses ...
[54]
Experience-dependent plasticity in early stations of sensory ... - NIH
Experience-dependent structural plasticity was shown not to be restricted to the cerebral cortex, as it also occurs at subcortical and even peripheral levels.
[55]
Maturation of striatal dopamine supports the development of ...
Jan 6, 2025 · Habit formation is an important part of normative development, reflecting the shift from variable to stable behavioral patterns from adolescence ...
[56]
Sex differences in behavior and neural development and their role ...
Striatal development occurs in a sex-dependent fashion. As with other regions, adolescent boys lag behind girls, reaching peak striatal volume at 14.7 and 12.1 ...
[57]
Activation of direct and indirect pathway medium spiny neurons ...
A central theory of basal ganglia function is that striatal neurons expressing the D1 and D2 dopamine receptors exert opposing brain-wide influences.
[58]
Segregation of D1 and D2 dopamine receptors in the striatal direct ...
These studies suggested that cortical inputs to the striatum activating the direct pathway are involved in the generation of motor behavior. In a landmark ...
[59]
Striatal direct pathway neurons play leading roles in accelerating ...
May 20, 2022 · Neural correlates of motor skill learning in D1 and D2 MSNs. The striatum is important for motor skill learning, and thought to guide movement ...
[60]
Direct and indirect pathway neurons in ventrolateral striatum ...
Oct 19, 2021 · The indirect pathway striatal MSNs express the D2-type dopamine receptors (D2-MSNs) and project indirectly to the output nuclei via the ...
[61]
Membrane Properties of Striatal Direct and Indirect Pathway ...
In direct pathway MSNs, excitability increased across experimental conditions and parameters, and also when applying DA or the D1 agonist SKF-81297 in presence ...
[62]
Basal Ganglia (Section 3, Chapter 4) Neuroscience Online
The caudate nucleus is a C-shaped structure that is closely associated with the lateral wall of the lateral ventricle. It is largest at its anterior pole (the ...
[63]
Putamen neurons process both sensory and motor information ...
The cerebellum and basal ganglia are traditionally regarded as important motor regulatory centers in the brain. The putamen projects to the primary motor cortex ...Missing: loop | Show results with:loop
[64]
Existence and Control of Go/No-Go Decision Transition Threshold in ...
The striatal MSNs expressing D1 and D2 type dopamine receptors initiate the direct ('Go') and indirect ('No-Go') pathways of the basal ganglia, respectively.
[65]
Existence and Control of Go/No-Go Decision Transition Threshold in ...
Apr 24, 2015 · The striatal MSNs expressing D1 and D2 type dopamine receptors initiate the direct ('Go') and indirect ('No-Go') pathways of the basal ganglia, ...
[66]
A Physiologically Plausible Model of Action Selection and ...
Dec 13, 2006 · We present a new spiking neuron model of the BG circuitry to test this proposal, incorporating all major features and many physiologically plausible details.<|control11|><|separator|>
[67]
Hedonic Hot Spot in Nucleus Accumbens Shell - PubMed Central
Abstract. μ-Opioid systems in the medial shell of the nucleus accumbens contribute to hedonic impact (“liking”) for sweetness, food, and drug rewards.
[68]
Opioid Limbic Circuit for Reward: Interaction between Hedonic ...
Feb 14, 2007 · μ-Opioid hotspots in the nucleus accumbens (NAc) and ventral pallidum (VP) help generate both reward hedonic impact (“liking”) and incentive motivation (“ ...
[69]
A neural substrate of prediction and reward - PubMed
Behavioral experiments suggest that learning is driven by changes in the expectations about future salient events such as rewards and punishments.
[70]
Ventral striatum: a critical look at models of learning and evaluation
Ventral striatum as a reinforcement learning critic. TDRL models have been remarkably successful in predicting decision-related neural activity based on ...
[71]
Neural Encoding in Orbitofrontal Cortex and Basolateral Amygdala ...
Mar 1, 1999 · Orbitofrontal cortex (OFC) is part of a network of structures involved in adaptive behavior and decision making.
[72]
Ventral Striatal Neurons Encode the Value of the Chosen Action in ...
The ventral striatum (VS) is thought to serve as a gateway whereby associative information from the amygdala and prefrontal regions can influence motor output ...
[73]
Goal-directed and habitual control in the basal ganglia - NIH
Oct 14, 2010 · These results show that the dorsomedial and the dorsolateral striatum regulate goal-directed and stimulus–response habitual control, ...
[74]
Decreased putamen activation in balancing goal-directed and ...
Goal-directed behavior is associated with the caudate nucleus and regions in the prelimbic prefrontal cortex, whilst habitual behavior is associated with the ...Decreased Putamen Activation... · 2. Method · 3. Results
[75]
Neuroimaging studies of the striatum in cognition Part I
Oct 8, 2015 · The prefrontal cortex is known to play an important role in executive functions, which refer to mental processes that enable an individual to ...<|control11|><|separator|>
[76]
Striatum-projecting prefrontal cortex neurons support working ...
Nov 2, 2023 · In addition to planning choice-related actions, prefrontal-striatal projections could be involved in impulsivity control, which is crucial for ...
[77]
Basal Ganglia Subcircuits Distinctively Encode the Parsing ... - NIH
Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known ...<|control11|><|separator|>
[78]
Differential Dynamics of Activity Changes in Dorsolateral and ...
It has been suggested that the dorsolateral striatum is important for the chunking of motor patterns as habits are formed and stamped in (Barnes et al., 2005; ...
[79]
Shaping Action Sequences in Basal Ganglia Circuits - PMC
Recent studies suggest that cortico-basal ganglia circuits are important for chunking isolated movements into precise and robust action sequences.
[80]
Striatal circuits, habits, and implications for obsessive-compulsive ...
Sep 19, 2014 · Clinical work early on suggested that dysfunction of the striatum might be important in the emergence of OCD symptoms. Comorbid OCD symptoms ...
[81]
Transdiagnostic variations in impulsivity and compulsivity in ...
Individual differences in impulsivity and compulsivity is thought to underlie vulnerability to a broad range of disorders and are closely tied to cortical- ...
[82]
Parkinson's Disease and Its Management: Part 1 - PubMed Central
Striatal dopamine depletion has been identified as the major cause of the disorder's motor symptoms,– which include resting tremor, “cogwheel” rigidity, and ...
[83]
Biology of Parkinson's disease: pathogenesis and pathophysiology ...
The characteristic motor impairments - bradykinesia, rigidity, and resting tremor - result from degenerative loss of midbrain dopamine (DA) neurons in the ...
[84]
Huntington's disease mouse models: unraveling the pathology ... - NIH
Huntington's disease (HD) is caused by an expansion of CAG repeats in the huntingtin gene (HTT), which leads to neurological deficits, including motor ...
[85]
Huntington Disease - StatPearls - NCBI Bookshelf - NIH
Apr 6, 2025 · Huntington disease is an autosomal dominant inherited neurodegenerative disorder caused by the elongation of CAG repeats on the short arm of ...Missing: indirect | Show results with:indirect
[86]
Huntington's Disease and the Striatal Medium Spiny Neuron
Huntington's disease is an autosomal dominant disorder caused by a mutation in the gene encoding the protein huntingtin on chromosome 4.
[87]
DYT-TOR1A dystonia: an update on pathogenesis and treatment
The most common mutation in TOR1A is caused by a GAG deletion in the fifth exon of the TOR1A gene, resulting in the loss of two adjacent glutamic acid residues ...
[88]
Structural and Functional Changes in Tourette Syndrome - PMC
The balance between indirect and direct pathways is regulated by the differential action of dopamine on neurons of the striatum, exerted by means of diffuse ...
[89]
Deep brain stimulation of the subthalamic nucleus preferentially ...
May 25, 2015 · Deep brain stimulation targeting the subthalamic nucleus (STN-DBS) is an effective surgical treatment for the motor symptoms of Parkinson's ...6-Ohda Lesion Of The Median... · Stn Dbs Electrode Implant · Enhanced Dendritic...
[90]
Mechanisms and targets of deep brain stimulation in movement ...
Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. ... Subthalamic deep brain stimulation does not induce ...
[91]
Schizophrenia, Dopamine and the Striatum - PubMed Central - NIH
Sep 28, 2018 · Schizophrenia and the Striatum Schizophrenia is a syndrome consisting of positive symptoms (such as delusions and hallucinations), negative ...
[92]
Dopamine, psychosis and schizophrenia: the widening gap between ...
Jan 31, 2018 · In most individuals with schizophrenia, excessive dopamine signalling in the associative striatum leads to positive symptoms.
[93]
A Possible Role for the Striatum in the Pathogenesis of the Cognitive ...
Mar 11, 2010 · The finding that the cognitive deficits in schizophrenia may arise not simply from alterations in the prefrontal cortex but also from a deficit ...
[94]
Ventral Striatum Activity in Response to Reward - NIH
The relationships between ventral striatal activity and residual manic or depressive symptoms (HAM-D, Young Mania Rating Scale, and Hypomanic Checklist–32 ...
[95]
Size and shape of the caudate nucleus in individuals with bipolar ...
Conclusions: These findings suggest that subtle rather than gross structural changes occur in the CN, which may not be detectable by volumetric analysis alone, ...
[96]
Neuroanatomical Abnormalities as Risk Factors for Bipolar Disorder
Conclusions: Possible candidates for neuroanatomical risk factors for BD are volumetric abnormalities of the subgenual prefrontal cortex, striatum, white matter ...
[97]
Two years changes in the development of caudate nucleus are ...
Caudate nucleus volume is enlarged in autism spectrum disorder (ASD) and is associated with restricted and repetitive behaviors (RRBs).Missing: early | Show results with:early
[98]
Caudate nucleus is enlarged in high-functioning medication-naive ...
Aug 1, 2007 · These results implicate caudate nucleus in autism, as an enlargement of this structure was disproportional to an increase in total brain ...
[99]
Early hyperactivity and precocious maturation of corticostriatal ...
Some autistic individuals exhibit abnormal development of the caudate nucleus and associative cortical areas, suggesting potential dysfunction of ...
[100]
Basal Ganglia Morphometry and Repetitive Behavior in Young ...
Enlargement of the left and right striatum, more specifically the left and right putamen, and left caudate, was observed in the ASD compared to the TD group.
[101]
Social Dysfunction and Neural Processing of Emotional Valence ...
Oct 10, 2024 · This study aims to determine whether social dysfunction across these psychiatric disorders is indeed coupled to altered neural processing of negative and ...
[102]
Dissecting autism and schizophrenia through neuroimaging genomics
Jul 15, 2021 · ... nucleus accumbens showed decreased volumes in CNV schizophrenia carriers. Thalamic and hippocampal volumes appeared to mediate effects on cognitive performances ...
[103]
Social interaction as a unique form of reward – Insights from healthy ...
May 2, 2025 · Impaired social reward learning related to atrophy of the orbitofrontal and lateral prefrontal cortices, as well as the nucleus accumbens and putamen (Wong et ...
[104]
Neurobiologic Processes in Drug Reward and Addiction - PMC
The stimulants cocaine and amphetamine directly amplify the mesolimbic dopaminergic signal at the postsynaptic DA receptor through different synaptic mechanisms ...
[105]
Addiction: Beyond dopamine reward circuitry - PNAS
These findings show that addiction affects not only the DA reward circuit but circuits involved with conditioning/habits, motivation, and executive functions.
[106]
Drug Addiction: Updating Actions to Habits to Compulsions Ten ...
Aug 7, 2015 · TRANSITION FROM VENTRAL TO DORSAL STRIATUM . ... alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum.
[107]
From the ventral to the dorsal striatum: Devolving views of their roles ...
▻ Habitual drug seeking and taking depend upon dorsolateral striatum. ▻ Compulsive drug seeking in addiction reflects loss of prefrontal control over habits. ▻ ...Missing: seminal papers
[108]
Dopamine in Drug Abuse and Addiction: Results of Imaging Studies ...
In contrast, long-term drug use seems to be associated with decreased DA function, as evidenced by reductions in D2 DA receptors and DA release in the striatum ...
[109]
ΔFosB: A sustained molecular switch for addiction - PMC - NIH
ΔFosB represents one mechanism by which drugs of abuse produce relatively stable changes in the brain that contribute to the addiction phenotype.Missing: seminal | Show results with:seminal
[110]
FosB: A sustained molecular switch for addiction - PNAS
ΔFosB accumulates in certain brain regions outside the nu- cleus accumbens and dorsal striatum after chronic exposure to cocaine. Prominent among these regions ...Missing: seminal | Show results with:seminal
[111]
Pathological gamblers display cortico-striatal hypersensitivity to ...
Pathological gamblers show U-shaped neural response to appetitive and aversive bets. This hypersensitivity is found in a cortico-striatal network, ie caudate ...Missing: seminal | Show results with:seminal
[112]
Gambling Disorder and Other Behavioral Addictions - PubMed Central
Relatively decreased ventral striatal activation has been reported in disordered gamblers during monetary reward anticipation and simulated gambling. In ...Missing: hypersensitivity seminal
[113]
Imaging addiction: D2 receptors and dopamine signaling in the ...
Imaging studies in addiction show a decrease in D2 receptors and dopamine release in the striatum. However, this decrease is seen across addictions, independent ...
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Thomas Willis' legacy on the 400th anniversary of his birth - PMC
In addition to the famous circle of Willis, he described several structures of the brain, such as the striatum, the internal capsule, the cerebellar peduncles, ...
[115]
Willis Identifies the Basal Ganglia | Research Starters - EBSCO
When Thomas Willis published Cerebri anatome (1664; The Anatomy of the Brain , 1681), he effectively founded the modern neurosciences, particularly neurology ...
[116]
The History of the Basal Ganglia: The Nuclei - ScienceDirect
His Traité d'anatomie et de physiologie (Vicq d'Azyr, 1786) contains several plates in which the various components of the basal ganglia, including the caudate ...
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Félix Vicq D'azyr (1748–1794) - Parkinsonism & Related Disorders
Vicq d'Azyr also made a clear distinction between the caudate nucleus and the putamen and noted the existence of the two segments of the globus pallidus.
[118]
Theodor Meynert - Hektoen International
Nov 18, 2021 · Meynert's powers of description were not the most lucid, and in 1896 Albert Köelliker renamed the Ansa-ganglion “Meynert's Basalganglion.” Fig 2 ...
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An essay on the shaking palsy. 1817 - PubMed
An essay on the shaking palsy. 1817. ... Parkinson Disease / physiopathology; Psychiatry / history; Spinal Cord / physiopathology. Personal name as subject. James ...
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Arvid Carlsson – Facts - NobelPrize.org
Carlsson discovered a neurotransmitter called dopamine in the brain and described its role in our ability to move. This led to the realization that Parkinson's ...
[121]
Control of Basal Ganglia Output by Direct and Indirect Pathway ... - NIH
Nov 20, 2013 · Basal ganglia research over the past 20 years has been guided by a model (Albin et al., 1989; DeLong, 1990) in which the direct and indirect ...Missing: 1980s | Show results with:1980s
[122]
Functional Connectivity of Human Striatum: A Resting State fMRI Study
Apr 9, 2008 · Here, we provide a comprehensive functional connectivity analysis of basal ganglia circuitry in humans through a functional magnetic resonance ...
[123]
The organization of the human striatum estimated by intrinsic ...
By examining the cerebral coupling patterns from six seed regions placed throughout the striatum, they demonstrated clear functional subdivisions. However ...
[124]
The evolutionary origins of the Global Neuronal Workspace in ...
Sep 13, 2023 · The subpallial basal ganglia (such as the striatum) are considered homologous across all vertebrates and are a major target of brainstem ...
[125]
Transgenic tools targeting the basal ganglia reveal both ...
Mar 26, 2024 · The cortico-basal ganglia circuit mediates decision making. Here, we generated transgenic tools for adult zebrafish targeting specific ...
[126]
Anatomy of a songbird basal ganglia circuit essential for vocal ... - NIH
Vocal learning in songbirds requires an anatomically discrete and functionally dedicated circuit called the anterior forebrain pathway (AFP).
[127]
Parallel Emergence of a Compartmentalized Striatum with the ...
Apr 19, 2019 · The location, neurochemical properties, and connectivity of these neuronal populations suggested a homology to striatal neurons from mammals.
[128]
Behavioral flexibility is increased by optogenetic inhibition of ... - NIH
The nucleus accumbens may play an important role in behavioral flexibility, representing learned stimulus–reward associations in neural activity during response ...
[129]
Activation of the rostral nucleus accumbens shell by optogenetics ...
Feb 13, 2023 · In this study, we investigated whether a short-lasting stimulation/inhibition of the NAc by optogenetics led to a similar result.
[130]
Anatomical and Functional Comparison of the Caudate Tail in ... - NIH
Jul 17, 2023 · Overall, the expansion of the primate brain along the rostral ... In both rodents and primates, the rostral part of the striatum is ...
[131]
Primate homologs of mouse cortico-striatal circuits - PMC
Apr 16, 2020 · We compared cortico-striatal circuits across humans, non-human primates, and mice using resting-state fMRI data in all species.