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Internal capsule

The internal capsule is a subcortical white matter structure situated in the inferomedial portion of each cerebral hemisphere, consisting of densely packed bundles of myelinated ascending and descending fiber tracts that connect the cerebral cortex to subcortical structures, the brainstem, and the spinal cord.^[1] It forms a V-shaped configuration on transverse sections, bounded laterally by the lentiform nucleus (putamen and globus pallidus) and medially by the thalamus and caudate nucleus.^[1]^[2] Anatomically, the internal capsule is divided into several segments: the anterior limb, located between the head of the caudate nucleus and the lentiform nucleus; the genu, a bend near the midline; the posterior limb, separating the thalamus from the lentiform nucleus; the retrolenticular part, posterior to the lentiform nucleus; and the sublenticular part, inferior to it.^[1]^[2] Superiorly, its fibers radiate outward as the corona radiata to reach the cerebral cortex, while inferiorly, they converge into the cerebral peduncles of the midbrain.^[1] Key tracts within it include the corticospinal tract in the posterior limb for voluntary motor control, corticobulbar fibers in the genu for cranial nerve innervation, thalamocortical radiations in the anterior limb for sensory and cognitive processing, and optic and auditory radiations in the posterior parts for visual and auditory relay.^[1]^[3] Its blood supply primarily arises from small perforating branches of the anterior cerebral, middle cerebral, and anterior choroidal arteries, making it vulnerable to ischemic damage.^[1] Clinically, the internal capsule's compact organization of critical pathways means that lesions, such as those from lacunar infarcts or hemorrhages, often produce characteristic syndromes like pure motor hemiparesis or sensorimotor deficits affecting the contralateral face, arm, and leg.^[3]^[1] This structure's role in integrating cortical and subcortical functions underscores its importance in neuroscience and neurology.^[2]

Anatomy

Location and gross morphology

The internal capsule is a subcortical white matter structure composed of a compact bundle of myelinated fibers that separates the lentiform nucleus (comprising the putamen and globus pallidus) from the thalamus and caudate nucleus.^[1] In horizontal sections of the brain, it forms a characteristic V-shaped configuration, with the apex directed medially and the open end laterally, reflecting its role as a condensed pathway for projection fibers.^[1] This V-shape consists of an anterior limb positioned between the head of the caudate nucleus and the lentiform nucleus, a genu at the bend, and a posterior limb between the thalamus and the posterior aspect of the lentiform nucleus.^[1] Positioned in the inferomedial aspect of each cerebral hemisphere, the internal capsule extends superiorly into the corona radiata, where fibers fan out toward the cerebral cortex, and inferiorly toward the crus cerebri in the midbrain.^[1] It traverses the basal ganglia region, creating a distinct boundary within the diencephalon and telencephalon. The structure is widest at its middle portion, where the anterior and posterior limbs diverge, giving it a broadened appearance in coronal views. Key relations include lateral bounding by the lentiform nucleus, medial adjacency to the thalamus and caudate nucleus, superior continuity with the diverging fibers of the corona radiata, and inferior extension into the brainstem structures such as the cerebral peduncles.^[1] These spatial relationships highlight its central position within the deep brain structures, facilitating efficient passage of fibers through a constrained anatomical corridor.^[4]

Anterior limb

The anterior limb of the internal capsule is bounded medially by the head of the caudate nucleus and laterally by the lentiform nucleus, forming a key segment of the white matter tract that separates these basal ganglia structures.^[1] This positioning situates the anterior limb as the forward extension connecting the frontal lobe to subcortical regions, including the thalamus and brainstem, without extending into the V-shaped bend of the overall capsule.^[1] In terms of superior-inferior extent, the anterior limb spans from the corona radiata above, where fibers fan out toward the cortical surface, to the cerebral peduncle below, where they converge into descending pathways.^[1] Unlike the posterior limb, it lacks distinct internal partitioning into somatotopically organized zones for sensory or motor functions, maintaining a more uniform structure along its course.^[1] The general composition of the anterior limb consists primarily of projection fibers that link the frontal cortex to subcortical structures, such as the anterior thalamic radiation projecting from the anterior and medial thalamic nuclei to the prefrontal and cingulate cortices, and frontopontine fibers descending from the frontal lobe to pontine nuclei.^[1] It notably lacks major somatosensory or visual components, distinguishing it from adjacent segments of the capsule.^[1] Anatomically, it represents one of the thinnest portions of the internal capsule, adjacent medially to the head of the caudate nucleus throughout its length.^[5]^[1]

Genu

The genu of the internal capsule represents the acute angular bend where the anterior and posterior limbs converge, forming the "knee" of the characteristic V-shaped configuration of this white matter structure.^[1] This junction is positioned at the level of the interventricular foramen (foramen of Monro), immediately lateral to the ventricular surface, and lies at the apex of the pallidal portion of the lentiform nucleus.^[6] Anatomically, it is bounded laterally by the globus pallidus and medially by the thalamus, serving as a critical transitional zone between the frontal and more posterior projections.^[1] In its transitional role, the genu functions as a pivotal junction where fibers curve from the anterior limb's predominantly frontopontine pathways toward the posterior limb's sensorimotor tracts, facilitating the integration of cortical outputs.^[7] It primarily contains the apex of the corticobulbar tract, which carries motor fibers from the cortex to cranial nerve nuclei in the brainstem, along with short association fibers such as frontopontine projections and components of the superior thalamic radiation connecting ventral thalamic nuclei to the postcentral gyrus.^[1] These fiber arrangements underscore the genu's role in coordinating cranial motor control and thalamocortical relay functions. The genu measures approximately 5-10 mm in width, with mean dimensions reported as 6 ± 0.62 mm on the left and 6.1 ± 0.58 mm on the right in healthy adults, based on MRI assessments.^[8] On axial MRI slices, it appears as a distinct hypointense bend on T1-weighted images and hyperintense on T2-weighted sequences, readily identifiable due to its oblique orientation and contrast with adjacent gray matter structures like the caudate nucleus and lentiform nucleus.^[9] This visibility aids in clinical evaluation of potential ischemic or degenerative changes in this region.^[10]

Posterior limb

The posterior limb constitutes the largest and most prominent division of the internal capsule, forming its widest segment. It extends anteriorly from the genu to the retrolenticular part posteriorly, marking the primary conduit for major projection fibers in this region. Bounded medially by the thalamus and laterally by the lentiform nucleus, it is separated from the thalamic structures along its medial edge.^[1]^[11] Internally, the posterior limb is segmented into three approximate thirds based on functional organization: an anterior third primarily associated with motor pathways, a central third containing a mix of projections with somatotopic arrangement, and a posterior third linked to sensory relays. This division underscores its role as a critical interface for integrated neural traffic, with the overall structure reaching its maximum breadth in this limb. The anterior third notably houses the "knee" of the corticospinal tract, where fibers exhibit a characteristic bend reflecting upper body representation. In terms of spatial relations, the posterior limb is positioned lateral to the thalamus and medial to the globus pallidus, forming part of the V-shaped configuration of the internal capsule in horizontal sections. Posteriorly, it transitions continuously into the optic radiation, facilitating the extension of visual pathways beyond the lentiform nucleus. These relations highlight its embedded position within the basal ganglia framework, optimizing the funneling of fibers toward lower brainstem structures.^[1]^[11]

Retrolenticular and sublenticular parts

The retrolenticular part of the internal capsule lies immediately posterior to the lentiform nucleus, forming a posterior extension of the structure that diverges from the posterior limb. This segment primarily contains the superior division of the optic radiation (geniculocalcarine tract), consisting of fibers originating from the lateral geniculate nucleus of the thalamus and projecting to the upper visual cortex along the superior bank of the calcarine sulcus in the occipital lobe. It also includes temporoparietal association fibers that interconnect cortical regions in the temporal and parietal lobes, facilitating higher-order sensory integration.^[1]^[12]^[10] The sublenticular part is positioned inferior to the lentiform nucleus, representing a more ventral and lateral extension compared to the retrolenticular segment. It carries the inferior division of the optic radiation, known as Meyer's loop, which arcs anteriorly into the temporal lobe before curving posteriorly to reach the inferior bank of the calcarine sulcus, conveying information about the superior visual field. Additionally, this part transmits auditory radiations from the medial geniculate nucleus to the primary auditory cortex in the transverse temporal gyri of Heschl.^[1]^[12]^[10] Both the retrolenticular and sublenticular parts exhibit distinct anatomical positions, with the retrolenticular segment oriented more superiorly and the sublenticular more inferiorly and laterally, allowing for their fanning out into the overlying corona radiata as they ascend toward the cerebral cortex. These regions are adjacent to the temporal horn of the lateral ventricle, with the optic radiations in particular skirting its lateral wall, and they maintain continuity with the posterior aspects of the thalamus from which many of their fibers originate.^[1]^[10]

Blood supply

The blood supply to the internal capsule is primarily provided by small perforating arteries that arise from the circle of Willis and its major branches, ensuring targeted perfusion to this critical white matter structure.^[1] The lenticulostriate branches of the middle cerebral artery supply the superior two-thirds of the anterior limb, genu, and posterior limb, penetrating the lateral aspects to vascularize the bulk of the capsule's core regions.^[13] These lateral striate arteries, numbering 10 to 20 per hemisphere, originate from the M1 segment of the middle cerebral artery and course superiorly to reach the putamen, caudate nucleus, and adjacent internal capsule fibers.^[3] Specific territories are delineated by additional vessels for the inferior and medial portions. The recurrent artery of Heubner, a branch of the anterior cerebral artery, supplies the inferior anterior limb and medial aspects of the striatum.^[1] The anterior choroidal artery, arising from the internal carotid artery, provides blood to the inferior posterior limb, parts of the genu, and the retrolenticular and sublenticular parts, extending posteriorly to also perfuse the optic tract and lateral geniculate nucleus.^[13] Branches from the anterior cerebral artery contribute to the medial genu, while indirect supply to the retrolenticular part may involve posterior cerebral artery territories via anastomotic networks at the periphery.^[1] Venous drainage follows a dual pattern aligned with the arterial territories. Superior striate veins drain the upper internal capsule into tributaries of the internal cerebral veins, which converge at the interventricular foramen to form the great cerebral vein of Galen.^[1] Inferior striate veins collect blood from the putamen, caudate nucleus, and lower capsule, emptying into the basal veins of Rosenthal, which course laterally around the midbrain before joining the great cerebral vein.^[1] The internal capsule's vasculature is characterized by an end-arterial configuration, with the deep perforating branches lacking significant collateral anastomoses, rendering them vulnerable to occlusion and subsequent lacunar infarcts.^[1] This isolated supply pattern underscores the structure's susceptibility to hypertensive or embolic insults targeting these small vessels.^[3]

Fiber tracts

Descending fibers

The descending fibers of the internal capsule comprise major projection tracts originating from the cerebral cortex that convey efferent signals to subcortical nuclei, the brainstem, and the spinal cord. These fibers converge from the corona radiata above and traverse the internal capsule in a compact, V-shaped configuration before diverging into the cerebral peduncles of the midbrain, where they continue to the pons, medulla, or targeted subcortical structures.^[1]^[7] The corticospinal tract arises primarily from neurons in the primary motor cortex (Brodmann area 4), premotor cortex (area 6), and supplementary motor area, with additional contributions from the somatosensory cortex (areas 3, 1, and 2). These fibers descend through the anterior two-thirds of the posterior limb of the internal capsule, maintaining a somatotopic organization in which upper extremity (arm and hand) fibers occupy the more anterior position near the genu, while lower extremity (leg and foot) fibers are positioned posteriorly.^[1]^[14] Beyond the internal capsule, the tract proceeds through the middle three-fifths of the cerebral peduncles, basis pontis, and medullary pyramids, where approximately 75-90% of fibers decussate at the pyramidal decussation to form the lateral corticospinal tract.^[7] The corticobulbar tract originates from the primary motor cortex, premotor cortex, and supplementary motor areas, targeting motor nuclei of cranial nerves in the brainstem. These fibers course through the genu of the internal capsule, positioned mediodorsally relative to the corticospinal tract, before entering the cerebral peduncles and branching to innervate nuclei such as those for the facial (VII), trigeminal (V), hypoglossal (XII), and ambiguus (IX, X) nerves.^[1]^[15] Frontopontine fibers emerge from the frontal lobe, including the premotor, supplementary motor, prefrontal, and orbitofrontal cortices, and descend via the anterior limb of the internal capsule to reach the pontine nuclei. In the brainstem, these fibers decussate and contribute to the pontocerebellar pathway, facilitating cerebrocerebellar coordination.^[1]^[7] Corticostriatal fibers, originating from prefrontal and motor cortical regions, traverse the anterior limb of the internal capsule to project to the striatum (caudate nucleus and putamen), forming part of the corticofugal projections involved in basal ganglia circuitry. Similarly, corticothalamic fibers from various cortical areas, including motor and prefrontal regions, pass through the posterior limb and retrolenticular part of the internal capsule to reach thalamic nuclei such as the ventral lateral nucleus, establishing reciprocal loops for cortical-subcortical integration.^[1]^[16]

Ascending fibers

The ascending fibers of the internal capsule primarily consist of thalamocortical radiations that relay sensory information from thalamic nuclei to the cerebral cortex. These fibers originate from various thalamic relay nuclei, which receive inputs from brainstem and spinal cord structures, and ascend through the internal capsule to reach specific cortical areas.^[1]^[7] Thalamocortical radiations carrying somatosensory information arise from the ventral posterior nucleus of the thalamus and pass through the posterior third of the posterior limb of the internal capsule, projecting to the postcentral gyrus in the parietal cortex. These include third-order neurons of the dorsal column-medial lemniscus pathway for touch, vibration, and proprioception, as well as the spinothalamic tract for pain and temperature, which decussate in the spinal cord or medulla before synapsing in the thalamus. The fibers maintain a somatotopic organization within the posterior limb, with representations of the body inverted relative to cortical mapping.^[1]^[17]^[7] Optic radiations, conveying visual information, originate from the lateral geniculate nucleus of the thalamus and traverse the retrolenticular and sublenticular parts of the internal capsule before fanning out to the occipital cortex. These fibers include Meyer's loop, which loops anteriorly around the temporal horn of the lateral ventricle to carry information from the inferior visual fields, while superior field representations travel more directly posteriorly.^[1]^[17]^[7] Auditory radiations arise from the medial geniculate nucleus and course through the sublenticular part of the internal capsule to reach the transverse temporal gyri of Heschl in the superior temporal lobe. These fibers relay tonal and spatial auditory inputs from the inferior colliculus, maintaining a tonotopic organization along their path.^[1]^[7]

Association fibers

The internal capsule is dominated by projection fibers, with no major association fibers traversing its structure. Association fibers, which connect different cortical regions within the same cerebral hemisphere, such as components of the superior longitudinal fasciculus, run more superficially and do not significantly pass through the internal capsule.^[1]

Function

Motor pathways

The motor pathways within the internal capsule primarily consist of descending fiber tracts originating from the cerebral cortex, facilitating voluntary movement control through connections to the brainstem, spinal cord, and subcortical structures. These pathways include the corticospinal and corticobulbar tracts, which traverse the genu and posterior limb of the internal capsule, enabling precise motor execution for skilled movements and cranial nerve functions.^[1] The corticospinal tract, also known as the pyramidal tract, serves as the principal pathway for voluntary, fine motor control of the limbs and trunk, with approximately 90% of its fibers decussating at the medullary pyramids to innervate contralateral lower motor neurons in the spinal cord.^[18] This decussation ensures that cortical commands from one hemisphere predominantly control the opposite side of the body, supporting coordinated actions such as grasping or walking.^[19] The corticobulbar tract complements the corticospinal pathway by projecting to cranial nerve nuclei in the brainstem, providing motor innervation to muscles of the face, head, and neck. These fibers exhibit bilateral innervation to most cranial nerve nuclei (e.g., V, VII for mastication and upper face, IX-XII for swallowing and phonation), ensuring redundancy and recovery potential after unilateral lesions, while the lower facial nucleus receives primarily contralateral input, which can lead to isolated facial weakness in capsular strokes.^[15] This organization supports essential functions like facial expression, mastication, and deglutition, with fibers passing through the genu of the internal capsule before descending via the cerebral peduncles.^[15] Integration with the basal ganglia occurs through corticostriatal fibers that course through the internal capsule, linking the motor cortex to the striatum (caudate and putamen) to modulate movement initiation, inhibition, and sequencing via direct and indirect pathways.^[20] These projections, primarily from the premotor and supplementary motor areas, facilitate goal-directed behaviors by balancing excitatory and inhibitory influences on thalamocortical loops, with the putamen playing a key role in habitual motor control.^[21] Somatotopic organization within the internal capsule arranges these motor fibers spatially: face and tongue representations in the genu, arm and hand in the anterior portion of the posterior limb, and leg and foot in the posterior portion of the posterior limb, allowing for localized lesion effects on specific body regions.^[22] This arrangement, confirmed by diffusion tractography, underscores the capsule's role in segregated motor control.^[23]

Sensory pathways

The ascending sensory fibers within the internal capsule primarily transmit somatosensory information from the thalamus to the cerebral cortex via the posterior limb, relaying touch, proprioception, and pain sensations from the contralateral side of the body. These fibers originate in the ventral posterolateral (VPL) nucleus of the thalamus and project through the posterior third of the posterior limb to terminate in the primary somatosensory cortex located in the postcentral gyrus and posterior paracentral lobule.^[1]^[24] The medial lemniscus pathway carries discriminative touch and proprioception, while the neospinothalamic tract conveys sharp pain and temperature, both maintaining a contralateral representation.^[24] Visual information travels through the internal capsule via the geniculocalcarine tract, or optic radiations, which originate from the lateral geniculate nucleus (LGN) of the thalamus and course through the retrolenticular and sublenticular parts to reach the primary visual cortex in the calcarine fissure of the occipital lobe. These fibers preserve retinotopic organization, with macular (central) vision represented by a larger proportion of neurons compared to peripheral vision, which is processed more rostrally.^[1]^[25] Partial lesions in these pathways, such as in Meyer's loop of the sublenticular segment, can disrupt specific visual fields, leading to quadrantanopia.^[25] Auditory sensory pathways pass through the sublenticular part of the internal capsule, where fibers from the medial geniculate nucleus project to the primary auditory cortex in Heschl's gyrus (superior temporal gyrus) for processing sound frequency, intensity, and localization. These radiations enable binaural integration for sound localization, with tonotopic organization in the cortex where low frequencies are mapped laterally and high frequencies medially.^[1]^[26] The somatosensory fibers in the posterior limb exhibit somatotopic organization, mirroring the sensory homunculus of the postcentral gyrus, with a progression from face and hand representations anteriorly near the genu, to arm and trunk more centrally, and leg and foot posteriorly.^[1]^[24] This arrangement places cervical regions anteriorly, lower extremities posteriorly, and foot/anogenital areas medially, facilitating precise spatial mapping of contralateral body sensations.^[1]

Other roles

The internal capsule facilitates cognitive loops through its corticothalamic and thalamocortical fibers, particularly in the anterior limb, which connect the prefrontal cortex to thalamic nuclei such as the mediodorsal thalamus. These pathways support attention and executive functions by enabling reciprocal communication that modulates working memory, decision-making, and cognitive control. Disruption in these circuits, as observed in neuroimaging studies, correlates with deficits in prefrontal-dependent tasks, underscoring their role in higher-order processing.^[27]^[28] In emotional regulation, the anterior limb of the internal capsule carries fibers linking prefrontal regions to limbic structures, including projections from the orbitofrontal cortex to the thalamus and indirect connections to the amygdala and cingulate gyrus. These pathways contribute to mood stabilization and motivational drive by integrating emotional valence with behavioral responses, as evidenced in functional connectivity analyses of psychiatric conditions. Such connections allow for the modulation of affective states, facilitating adaptive responses to environmental cues.^[29] Cerebellar coordination is mediated by frontopontine fibers traversing the anterior and posterior limbs of the internal capsule, which originate from frontal motor and premotor cortices and project to the pontine nuclei. These fibers relay cortical inputs to the cerebellum via the middle cerebellar peduncle, supporting motor learning, timing, and balance through error-based adjustments in ongoing movements. This corticopontocerebellar pathway enables the refinement of complex actions beyond basic execution, as demonstrated in tract-tracing studies.^[1] The internal capsule plays a key role in bidirectional communication within cortico-basal ganglia-thalamocortical loops, with thalamocortical fibers in the anterior limb returning signals from the thalamus to the cortex after processing in the striatum and globus pallidus. These feedback mechanisms are essential for habit formation, allowing the consolidation of stimulus-response associations through reinforcement learning in the dorsolateral striatum. Dopaminergic modulation within these circuits strengthens habitual behaviors over time, as shown in computational models of basal ganglia function.^[30]^[31]

Development

Embryonic formation

The internal capsule originates during the division of the prosencephalon (forebrain) into its primary vesicles, the telencephalon and diencephalon, which occurs early in human embryogenesis. This partitioning establishes the foundational boundaries for subcortical structures, with the emerging internal capsule delineating the future separation between the basal ganglia components, such as the caudate nucleus medially and the lentiform nucleus laterally. As the telencephalic wall thickens and the diencephalon differentiates, the internal capsule begins to form as a conduit for axonal projections crossing this junction.^[1] Initial structuring of the internal capsule occurs around weeks 6 to 8 of gestation, when pioneering axons from the telencephalon extend toward the diencephalon, creating the first organized fiber bundles. This timeline aligns with the rapid expansion of the cerebral hemispheres and the onset of thalamocortical connectivity, where thalamic neurons send axons invading the telencephalic subventricular zone to establish reciprocal pathways. The characteristic V-shape of the internal capsule emerges during this phase, with the apex pointing medially as pioneering striatonigral axons from the striatum penetrate between the developing striatum and pallidum, guiding subsequent thalamocortical and corticofugal axons, while thalamic axons follow these scaffolds.^[32]^[33] Key developmental processes include the tangential migration of neuroblasts from ganglionic eminences and the radial outgrowth of axons, both orchestrated by chemoattractive and chemorepulsive cues. Netrins, particularly netrin-1 expressed in the internal capsule anlage and subplate, promote axonal attraction and outgrowth from cortical progenitors toward the diencephalon. Complementarily, semaphorins (e.g., Sema3A and Sema6A) via plexin receptors provide repulsive signals to refine trajectory and prevent ectopic branching, ensuring precise bundling within the capsule; for instance, semaphorin-plexin interactions in guidepost cells at the internal capsule-thalamus interface direct thalamocortical axons.^[34]^[35]^[36] Genetic regulation is critical for this patterning, with transcription factors like FOXG1 expressed in the telencephalon orchestrating ventral forebrain identity and axonal routing. FOXG1 maintains the balance between telencephalic and diencephalic domains, and its disruption—through mutations or deletions—impairs prosencephalic cleavage, leading to holoprosencephaly and failure of internal capsule formation, as evidenced in mouse models where Foxg1-null embryos exhibit absent or malformed capsule tracts.^[37] These molecular mechanisms ensure the internal capsule's role as a foundational white matter highway before subsequent postnatal refinements.

Postnatal myelination

The postnatal myelination of the internal capsule continues the embryonic process, building upon the preformed axonal scaffold to insulate fibers for efficient neural transmission. At birth in full-term infants, the posterior limb of the internal capsule is partially myelinated, appearing hyperintense on T1-weighted MRI and hypointense on T2-weighted sequences, while the anterior limb remains unmyelinated.^[38] Myelination of the anterior limb begins around 4 months of age, with visible T1 hyperintensity, and progresses with faint T2 hypointensity by 6 months; by 9-12 months, both limbs show substantial myelination on T2-weighted images, achieving near-completion by 18-24 months.^[38] This timeline reflects a posterior-to-anterior gradient within the capsule, aligning with the overall caudal-to-rostral progression of brain myelination.^[39] The myelination process involves the proliferation, migration, and differentiation of oligodendrocytes, which extend processes to wrap multiple axons in multilayered myelin sheaths, increasing axonal insulation and supporting saltatory conduction.^[40] In the internal capsule, oligodendrocyte maturation follows the established axonal tracts, with active myelin deposition most rapid in the first 6-9 months before decelerating.^[39] This wrapping enhances action potential velocity by 10-100 times compared to unmyelinated axons, facilitating coordinated motor and sensory signaling.^[38] Functionally, timely myelination of the internal capsule is crucial for early motor development; incomplete or delayed myelination, such as reduced fractional anisotropy in the posterior limb, correlates with motor delays and poor neurodevelopmental outcomes at 2 years.^[41] Disruptions in this process can impair signal transmission speed, contributing to deficits in movement coordination.^[42] On imaging, unmyelinated regions of the internal capsule in infants appear hyperintense on T2-weighted MRI due to higher water content, with progressive hypointensity as myelin accumulates; T1/T2 ratio mapping quantifies this, showing rapid increases in the posterior limb (R=0.68 at birth) and slower in the anterior limb.^[38]^[39] These changes provide a non-invasive marker for assessing normal versus delayed maturation.^[39]

Clinical significance

Vascular lesions

The internal capsule is particularly vulnerable to vascular lesions due to its reliance on small penetrating arteries, such as the lenticulostriate branches of the middle cerebral artery, which supply its anterior and posterior limbs.^[43] Ischemic and hemorrhagic pathologies disrupt this blood supply, leading to acute neurological deficits primarily through infarction or bleeding in subcortical white matter tracts. These lesions often result from underlying small vessel disease, with the posterior limb being more frequently affected owing to its partial vascularization by the anterior choroidal artery, which has limited collaterals.^[44]^[45] Lacunar infarcts represent a common ischemic lesion in the internal capsule, arising from small vessel disease primarily driven by chronic hypertension. These infarcts occur due to occlusion of the lenticulostriate arteries, which are end-arteries lacking significant collateral flow, resulting in small, deep infarctions typically less than 15 mm in diameter.^[46] A classic presentation is pure motor hemiparesis, where infarction in the posterior limb disrupts corticospinal tracts, causing contralateral facial, arm, and leg weakness without sensory or cognitive involvement.^[46] This syndrome accounts for approximately 45% of lacunar strokes and stems from lipohyalinosis or microatheroma formation in the vessel walls induced by sustained high blood pressure.^[46] Hemorrhagic strokes in the internal capsule are frequently hypertensive in origin, involving rupture of Charcot-Bouchard microaneurysms on deep perforating arteries. These aneurysms, measuring 0.3 to 2 mm, develop in response to chronic hypertension and fibrinoid necrosis, commonly affecting lenticulostriate vessels supplying the basal ganglia and adjacent internal capsule.^[47] Rupture leads to capsular hemorrhage with rapid expansion, causing mass effect through local compression of surrounding structures and potential extension into the ventricular system.^[47] Such events often originate in the putamen and propagate to the posterior limb, exacerbating tissue damage via secondary ischemia from elevated intracranial pressure.^[48] Key risk factors for these vascular lesions include atherosclerosis, which promotes plaque formation in proximal vessels, and diabetes mellitus, which accelerates small vessel arteriolosclerosis and endothelial dysfunction.^[43] The incidence is notably higher in the posterior limb, attributable to the anterior choroidal artery's supply, which is more susceptible to hypertensive changes and has a higher prevalence of occlusive events in diabetic patients.^[45] The underlying pathophysiology involves end-arterial occlusion, triggering a cascade of ischemia that forms wedge-shaped infarcts in the affected territory.^[43] Cytotoxic and vasogenic edema subsequently develops, peaking between 24 and 72 hours post-onset, which can amplify mass effect and neurological deterioration before partial resolution.^[49]

Associated syndromes

Lesions of the internal capsule can produce distinct lacunar syndromes characterized by specific patterns of motor, sensory, and speech deficits, depending on the affected region. These syndromes arise from small infarcts that disrupt white matter tracts, leading to contralateral symptoms without higher cortical involvement.^[1] Capsular hemiplegia, also known as pure motor hemiplegia, results from infarcts in the posterior limb of the internal capsule and manifests as a contralateral pure motor deficit involving the face, arm, and leg, with initial sparing of sensation. This syndrome accounts for approximately 45% of lacunar strokes and typically presents with hemiparesis without sensory loss, visual field defects, or aphasia.^[46]^[50] Dysarthria-clumsy hand syndrome occurs with lesions in the genu or anterior limb of the internal capsule, affecting corticobulbar fibers and leading to facial weakness, dysarthria, and contralateral hand incoordination despite preserved overall motor strength. Patients exhibit slurred speech and upper extremity clumsiness, often without significant lower limb involvement or sensory impairment.^[46]^[51]^[52] Sensorimotor stroke involves the posterior third of the internal capsule and produces combined contralateral hemiparesis and hemisensory loss, affecting both motor and sensory pathways. This syndrome, comprising about 20% of lacunar cases, features weakness and numbness in the face, arm, and leg, distinguishing it from pure motor variants.^[46]^[53] Ataxic hemiparesis, another lacunar syndrome, arises from lesions in the posterior limb or genu of the internal capsule, resulting in contralateral hemiparesis combined with ataxia or incoordination, often more pronounced in the upper limb, without significant sensory loss.^[46] Pure sensory stroke, typically involving the thalamus but sometimes extending to the internal capsule, presents with contralateral sensory deficits such as numbness or paresthesia in the face, arm, and leg, without motor involvement. It accounts for about 10% of lacunar syndromes.^[46] The prognosis for these internal capsule syndromes is generally favorable due to neuroplasticity, with many patients experiencing significant recovery through alternate neural pathways and rehabilitation. Lacunar strokes have a high survival rate of around 80-90% at four years and low initial mortality of 2-3%, with substantial functional improvement often occurring within the first three months and continuing up to 12 months post-onset. Approximately 70-80% of patients achieve independence in daily activities by one year, though risks of recurrence and cognitive decline persist.^[54]^[55]

Diagnostic imaging

Computed tomography (CT) serves as the initial imaging modality for suspected internal capsule lesions, primarily to exclude hemorrhage and detect early ischemic changes. Non-contrast CT can identify hypodensities in acute infarcts involving the internal capsule after approximately 12 hours from onset, reflecting cytotoxic edema, though sensitivity is low in the hyperacute phase (less than 6 hours).^[49] In lacunar infarcts, which commonly affect the internal capsule, CT may show subtle ill-defined hypodensities in the basal ganglia or white matter, but it often underperforms compared to magnetic resonance imaging (MRI) for small lesions.^[46] Magnetic resonance imaging (MRI) provides superior visualization of the internal capsule's anatomy and abnormalities. T1-weighted and T2-weighted sequences delineate the structure's white matter tracts against surrounding gray matter, with the posterior limb appearing hypointense on T1 and hyperintense on T2 in chronic gliosis following infarction.^[46] Diffusion-weighted imaging (DWI), a key MRI technique, detects acute infarcts with high sensitivity (88-100%) by showing restricted diffusion as early as 30 minutes post-onset, appearing as hyperintense signals in the affected capsule region; corresponding low apparent diffusion coefficient (ADC) values confirm viability loss.^[49] This is particularly useful for lacunar strokes, where DWI identifies focal restrictions as small as 0.2 mm in the posterior limb, aiding precise localization.^[46] Advanced modalities enhance assessment of internal capsule integrity and vascular supply. Diffusion tensor imaging (DTI) with tractography maps fiber orientation and quantifies microstructural damage via fractional anisotropy (FA), where reduced FA in the corticospinal tract correlates strongly with motor deficits and recovery potential post-infarct (correlation coefficient 0.82).^[56] Perfusion MRI evaluates hemodynamic compromise, revealing mismatched perfusion defects in the capsule's territory, which indicate ischemic penumbra and guide therapeutic decisions in acute settings.^[49] These techniques offer clinical utility in localizing lesions to specific motor or sensory pathways within the internal capsule, correlating imaging findings with hemiparesis or sensory loss in affected limbs. Serial DTI monitoring tracks recovery through FA improvements, predicting functional outcomes and informing rehabilitation strategies.^[56]^[46]

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Morphometry of the internal capsule on MR images in adult healthy ...
Aug 7, 2025 · Morphometry of the internal capsule on MR images in adult healthy individuals ... genu) and genu. angle of the internal capsule on MR images ...
[10]
1. Coronal sections. Sonography of the internal capsule and basal
Medially, the lenticular nucleus is delimited by the efferent pallidal fibers, the inferior end of genu of internal capsule as it approaches the cerebral.
[11]
Internal capsule: anatomy, structure and function - Kenhub
It is located in the inferomedial part of each cerebral hemisphere. More specifically, it is situated lateral to the thalamus and caudate nucleus, and medial to ...
[12]
Neuroanatomy Online: Lab 8 (ƒ7) - Visual System - Cortical Structures
... sublenticular and retrolenticular segments of the internal capsule. Note that the sublenticular optic radiation forms a major component of the external ...
[13]
Neuroanatomy Online: Lab 4 (ƒ3) - The Ventricles and Blood Supply
The medial striate artery passes laterally and enters the brain to supply medial areas of the corpus striatum of the basal ganglia and anterior internal capsule ...
[14]
https://teachmeanatomy.info/neuroanatomy/pathways/descending-tracts-motor/
[15]
Neuroanatomy, Corticobulbar Tract - StatPearls - NCBI Bookshelf
Corticobulbar fibers pass through the genu or bend of the internal capsule. From the internal capsule, these fibers enter into crus cerebri of the cerebral ...Missing: association | Show results with:association
[16]
Horizontal sections of the brain: Anatomy | Kenhub
Aug 16, 2015 · The internal capsule is essentially a conduit for both ascending and descending fibers. Frontopontine and thalamocortical fibers traverse ...
[17]
A taxonomy of the brain's white matter: twenty-one major tracts for ...
The internal capsule is a major ascending and descending fiber structure, carrying fibers between the cortex and the thalamus, brainstem, spinal cord, and ...
[18]
Dorsal component of the superior longitudinal fasciculus revisited
Mar 1, 2019 · ... superior longitudinal fasciculus (SLF-I) since the current ... internal capsule; Th = thalamus. See previous figure legends for ...Correlative Anatomy · Slf-I And Cingulum · Discussion
[19]
Neuroanatomy, Lateral Corticospinal Tract - StatPearls - NCBI - NIH
The lateral corticospinal tract contains over 90% of the fibers present in the corticospinal tract and runs the length of the spinal cord.
[20]
Neuroanatomy, Corticospinal Cord Tract - StatPearls - NCBI Bookshelf
Aug 14, 2023 · The corticospinal tract, AKA, the pyramidal tract, is the major neuronal pathway providing voluntary motor function.
[21]
Corticostriatal circuitry - PMC - PubMed Central - NIH
The DS is comprised of the caudate nucleus and putamen, which are separated in primates by the internal capsule. The rostroventral border of the caudate ...
[22]
The functional logic of corticostriatal connections - PMC
The corpus striatum is named for the striations formed by the cellular bridges linking the caudate and putamen across the internal capsule. Though anatomically ...
[23]
Somatotopic Organization of Motor Pathways in the Internal Capsule
The somatotopic organization of motor pathways should help neurologists explain the mechanism of clinical symptoms; for example, the absence of motor deficit ...
[24]
Somatotopic organization of motor pathways in the internal capsule
In the current study, we trace the fibers from the tongue, face, hand, and foot motor cortices by using probabilistic diffusion tractography and define their ...
[25]
Somatosensory Pathways (Section 2, Chapter 4) Neuroscience Online
All somatosensory pathways include a thalamic nucleus. The thalamic neurons send their axons in the posterior limb of the internal capsule to end in the ...
[26]
Chapter 15: Visual Processing: Cortical Pathways
The LGN axons in the retrolenticular segment of the internal capsule pass superiorly through the parietal lobe to end in the superior bank of the striate cortex ...
[27]
Chapter 13: Auditory System: Pathways and Reflexes
Ascending pathway for most auditory afferents. ... Thalamic afferents reach the superior temporal gyrus through the sub-lenticular portion of the internal capsule ...
[28]
Neuroanatomy, Thalamocortical Radiations - StatPearls - NCBI - NIH
Jul 24, 2023 · Thalamocortical radiations are involved in the control of cortical arousal and consciousness, and play a role in movement disorders such as Parkinson disease.<|control11|><|separator|>
[29]
Thalamic integrity underlies executive dysfunction in traumatic brain ...
In the case of frontal lobe functions, impairments in executive function could be accounted for by damage to the fiber projections to and from the dorsomedial ...Image Acquisition · Diffusion Tensor Imaging And... · DiscussionMissing: corticothalamic | Show results with:corticothalamic
[30]
Functional Segmentation of the Anterior Limb of the Internal Capsule
The anterior limb of the internal capsule (ALIC) carries thalamic and brainstem fibers from prefrontal cortical regions that are associated with different ...Missing: loops | Show results with:loops
[31]
Functional Neuroanatomy of the Basal Ganglia - PMC
The basal ganglia are responsible for motor control, and their proper functioning requires dopamine to be released at the input nuclei. Dopamine dysfunction is ...
[32]
Cortical and basal ganglia contributions to habit learning and ... - NIH
A widely-held view is that the basal ganglia are topographically segregated into a set of parallel loops from cortex, through the basal ganglia, and back to ...Missing: capsule | Show results with:capsule
[33]
Formation of the Mouse Internal Capsule and Cerebral Peduncle
Apr 20, 2022 · We show that striatonigral axons pioneer the internal capsule and cerebral peduncle and are temporally and spatially well positioned to provide guidance.
[34]
Mechanisms controlling the guidance of thalamocortical axons ... - NIH
On the contrary, thalamic axons turn very sharply away from the hypothalamus into the internal capsule in the direction of the diencephalic-telencephalic ...<|separator|>
[35]
A role for netrin-1 in the guidance of cortical efferents | Development
Dec 15, 1997 · (1997) has provided similar evidence that netrin- 1 may guide cortical axons toward the internal capsule in the rat. MATERIALS AND METHODS. C57 ...<|separator|>
[36]
Semaphorins act as attractive and repulsive guidance signals during ...
Dec 15, 1998 · Semaphorins act as attractive and repulsive guidance signals during the development ... Fibers in the internal capsule express semaphorin-binding ...
[37]
Semaphorin-Plexin signaling influences early ventral telencephalic ...
Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance ... internal capsule (IC) guidepost cells.
[38]
SHH AND GLI3 REGULATE FORMATION OF THE ... - PubMed Central
The resulting forebrain holosphere comprises Foxg1-positive telencephalic- and Foxg1-negative diencephalic territories. ... Genetics of ventral forebrain ...
[39]
[PDF] Normal Myelination
4. Imaging of myelination. By 4 months, myelination on T1 in the anterior limbs of the internal capsule as well as thickening of those areas previously ...
[40]
Assessment of normal myelination in infants and young children ...
Feb 28, 2023 · White matter myelination is an essential process of CNS maturation. It is believed that this process begins in the fifth fetal month and ...
[41]
Myelination Events | Neupsy Key
May 16, 2019 · Myelination involves oligodendroglial proliferation, migration, differentiation, alignment, and myelin deposition around axons, starting in the ...<|control11|><|separator|>
[42]
Understanding Brain Injury and Neurodevelopmental Disabilities in ...
One small study found that decreases in anisotropy in the internal capsule and occipital white matter correlated with poor motor outcome at two years corrected ...
[43]
Myelination may be impaired in neonates following birth asphyxia
Impairment of the myelination process is known to disturb motor and sensory functions, and to cause cognitive impairments (Gold et al., 2012, Nave and Bruce, ...Missing: incomplete | Show results with:incomplete
[44]
Ischemic Stroke - StatPearls - NCBI Bookshelf - NIH
Feb 21, 2025 · The M1 (horizontal) segment gives rise to the lenticulostriate arteries, which supply the basal ganglia and internal capsule. ... hemiparesis ...
[45]
Anatomy, Head and Neck, Striate Arteries - StatPearls - NCBI - NIH
Aug 9, 2025 · The lenticulostriate arteries (LSAs) branch from the MCA, a vessel that originates from the internal carotid artery (ICA) and courses ...
[46]
Anterior Circulation Stroke - Medscape Reference
Dec 30, 2024 · ... choroidal artery supplies the lateral thalamus and posterior limb of the internal capsule. ... risk factors, such as hypertension and diabetes ...
[47]
Lacunar Stroke - StatPearls - NCBI Bookshelf - NIH
Pure motor hemiparesis: Pure motor hemiparesis involves the posterior limb of the internal capsule, corona radiate, or ventral pons. · Ataxic-hemiparesis: Ataxic ...Missing: lenticulostriate | Show results with:lenticulostriate
[48]
Charcot-Bouchard Aneurysm - StatPearls - NCBI Bookshelf
The rupture of Charcot Bouchard aneurysms causes intracerebral bleeds in the deep structures of the brain, especially in patients predisposed to this condition ...Missing: capsule | Show results with:capsule
[49]
Clinical importance of the anterior choroidal artery: a review of ... - NIH
Feb 12, 2018 · An injury to the AChA can result in pallidal hemorrhage or intracerebral hematomas in the posterior limb of the internal capsule and the upper ...Missing: hypertensive | Show results with:hypertensive
[50]
Imaging of Stroke: Part 2, Pathophysiology at the Molecular and ...
72 hours [19, 20]. In this phase, imaging shows increased edema, mass effect, and possible herniation depending on the size and site of the infarct (Fig. 8).
[51]
Pure motor hemiplegia: CT study of 30 cases - PubMed
Pure motor hemiplegia (PMH) is a well defined syndrome usually caused by ischemic lesions of lacunar type located either in the internal capsule or in the pons.
[52]
Dysarthria--clumsy hand syndrome produced by capsular infarct
A 64-year-old hypertensive man presented with the dysarthria--clumsy hand syndrome, manifested by dysarthria, dysphagia, central facial weakness.
[53]
Clinical study of 35 patients with dysarthria-clumsy hand syndrome
The majority of patients in this study had internal capsule infarcts. The prognosis is good with striking similarity compared with other types of lacunar ...
[54]
Sensorimotor stroke due to thalamocapsular ischemia - PubMed
This case appears to be unique in that a sensorimotor stroke has been produced by a confirmed thalamocapsular infarct.
[55]
Long-term prognosis of symptomatic lacunar infarcts. A ... - PubMed
The 4-year survival rate was 80 +/- 4% and the 4-year survival rate without recurrent stroke was 85 +/- 3.5%. Using Cox proportional-hazards analysis, the ...
[56]
Late functional improvement after lacunar stroke - PubMed Central
Jul 21, 2018 · Patients with lacunar strokes have significant potential for late functional improvement from 3 to 12 months, which should motivate patients and clinicians.
[57]
Prediction of Upper Limb Motor Recovery after ... - :: Journal of Stroke
Jan 29, 2016 · This meta-analysis suggests strong correlation between DTI parameter FA and upper limb motor recovery. Well-designed prospective trials embedded ...