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Supplement

The term "supplement" has multiple meanings across various fields. In and , it commonly refers to dietary supplements intended to add nutrients to one's . In and , it denotes additional sections of newspapers or magazines. In and , it describes supplementary angles or supplemental structures. In and , it pertains to income supplements or regulatory addendums. The following sections provide detailed information on these and related uses.

Health and Nutrition

Dietary Supplements

Dietary supplements are products intended for ingestion that contain a dietary —such as a , , , , or other substance—designed to supplement the and provide nutrients that may not be consumed in sufficient quantities through alone. Unlike drugs, they are regulated by the U.S. (FDA) as foods rather than pharmaceuticals, meaning manufacturers are responsible for ensuring safety and accurate labeling before marketing, without pre-market approval required. Common forms include tablets, capsules, powders, and liquids, and they are widely available over-the-counter. Among the most prevalent types are multivitamin-mineral formulations, which provide a broad spectrum of essential nutrients; herbal supplements like for potential immune support and for energy enhancement; to promote gut health; and omega-3 fatty acids from for cardiovascular benefits. For instance, supplements are often recommended at 600–800 international units () daily for adults to support bone health and immune function, aligning with guidelines from the . These products are frequently used by consumers for purposes such as bolstering immunity, increasing energy levels, or aiding weight management, with multivitamins being the most commonly consumed category. The historical roots of dietary supplements trace back to the , when emerged as an early product to address nutrient deficiencies like , gaining popularity for its and D content. The modern industry took shape in the early following discoveries, with the first supplements appearing around 1916 and a post-World War II boom driven by synthetic production and widespread availability by the 1950s. A pivotal moment came in with the passage of the Health and Education Act (DSHEA), which classified supplements as a distinct category of separate from drugs, easing regulatory burdens on manufacturers while requiring substantiation. Today, the global market for dietary supplements is valued at approximately $185 billion as of 2023 and is projected to exceed $350 billion by 2033, reflecting growing consumer interest in preventive health. Production of dietary supplements involves sourcing raw ingredients from natural or synthetic origins, such as extracting herbs or synthesizing vitamins, followed by rigorous to ensure purity, potency, and absence of contaminants. Manufacturers must adhere to current good manufacturing practices (cGMP) outlined by the FDA, including testing raw materials for identity and strength. Independent verification programs, like the (USP) Dietary Supplements Verification Program, provide additional assurance by auditing facilities and confirming that products meet established standards for quality and label accuracy.

Medical and Therapeutic Supplements

Medical and therapeutic supplements encompass a range of vitamins, minerals, and other compounds used in clinical settings to address deficiencies, support treatment of chronic conditions, and prevent disease progression, often under medical supervision. These supplements are particularly valuable when dietary intake is insufficient, such as in cases of diagnosed deficiencies or specific health impairments. For instance, iron supplementation is a standard treatment for (IDA), where oral doses of 3 mg/kg/day in infants or 9–90 mg/day in pregnant women have been shown to reduce anemia risk by up to 70% and improve levels. Similarly, , typically combined with at doses of 500–1,200 mg/day calcium and 400–800 IU/day vitamin D, are employed for management in postmenopausal women, demonstrating a 15% reduction in total fracture risk and 30% in fractures in meta-analyses of randomized controlled trials (RCTs). In chronic conditions, (CoQ10) supplementation at 200–300 mg/day has shown benefits for cardiovascular health, particularly in patients, by improving symptoms, reducing major adverse cardiovascular events, and lowering all-cause mortality and hospitalization rates, as evidenced by the Q-SYMBIO RCT and subsequent meta-analyses. Fish oil-derived omega-3 fatty acids, such as (EPA) and (DHA), are used adjunctively for , with meta-analyses indicating that EPA monotherapy reduces cardiovascular events by 18% compared to combined EPA+DHA formulations. The (WHI) trial further supports the role of calcium plus (1,000 mg calcium + 400 IU vitamin D daily) in reducing risk by 29% among adherent postmenopausal women, though overall fracture prevention effects were modest in non-adherent participants. Safety concerns are significant with therapeutic supplements, as excessive intake can lead to adverse effects. from chronic high doses (>10,000 IU/day) causes symptoms including nausea, , , liver damage, and increased , with possible from single doses exceeding 660,000 IU in adults. Drug interactions pose additional risks; for example, St. John's wort, used for mild , inhibits serotonin reuptake and can precipitate when combined with selective serotonin reuptake inhibitors (SSRIs) like or sertraline, leading to symptoms such as , , and seizures in case reports and clinical observations. Recent developments through 2025 highlight advancing applications in microbiome and cognitive therapies. Probiotic supplementation with strains like Lactobacillus and Bifidobacterium has demonstrated neuroprotective effects in preclinical and early clinical trials by modulating the gut microbiome, improving clinical measures in conditions like Parkinson's disease and reducing inflammation-related symptoms in mental health disorders. For cognitive health, omega-3 fatty acids at doses around 2,000 mg/day show low-to-moderate evidence of enhancing attention and perceptual reasoning in meta-analyses of adults, with prospective studies linking higher intake to a 20% lower risk of all-cause dementia or cognitive decline, though effects in established Alzheimer's disease remain insignificant. Clinical guidelines from authoritative bodies emphasize supplements as adjuncts to diet rather than replacements. The (NIH) recommends supplementation for at-risk groups, such as pregnant women for iron and folic acid to prevent and neural tube defects, or older adults for and calcium when dietary sources are inadequate, based on assessed deficiencies via blood tests. The (WHO) advises multiple supplements, including iron (30–60 mg elemental daily) and folic acid, for pregnant women in high-deficiency settings to reduce maternal and low birthweight, while prioritizing food-based interventions for general populations.

Publishing and Media

Newspaper and Magazine Supplements

Newspaper and magazine supplements are additional printed sections or standalone glossy magazines distributed free with daily or weekend editions of newspapers, designed to provide specialized, engaging content that extends beyond standard news reporting. Their primary purpose is to boost reader loyalty, increase circulation, and attract advertisers by offering lifestyle-oriented extras that appeal to broader audiences. For instance, , a weekly insert since 1896, features , , and cultural essays, while T: The New York Times Style Magazine focuses on fashion, design, and luxury trends to draw high-end brand sponsorships. Similarly, 's Weekend supplement delivers in-depth articles on travel, food, and personal stories, enhancing the paper's appeal on Saturdays. These formats often include high-quality color printing and pull-out designs for easy separation, serving as a key revenue driver through . The historical evolution of supplements began in 19th-century amid advances in illustration and printing technology, with the Illustrated London News launching in 1842 as the world's first illustrated weekly newspaper, using wood engravings to visually document events like royal ceremonies and social reforms. This publication pioneered supplements, including a landmark color edition in 1855 that featured hand-colored lithographs, marking the introduction of color to mass-market news media and inspiring similar illustrated add-ons across . By the early , supplements expanded globally; in the United States, the Associated Sunday Magazines service debuted in 1903 under Joseph Palmer Knapp, supplying customized, general-interest content—such as fiction, humor, and family features—to independent newspapers in 12 cities, reaching over 1.5 million readers by 1914 and emphasizing cooperative advertising models. In the UK, issued 85 themed supplements between 1910 and 1917, often geographically focused (e.g., South American or Japanese editions with maps and trade articles), to promote British commerce and imperial ties, though production halted due to paper shortages. The mid-20th century saw further growth with widespread , turning supplements into profitable staples like Sunday lifestyle magazines. Common formats encompass weekly color inserts, holiday specials, and themed pull-outs, typically 20-100 pages long and bound separately for portability. Content emphasizes entertainment and leisure, including fashion editorials, travel guides, arts reviews, and interactive elements like puzzles; The Sunday Times' Style magazine, for example, highlights celebrity interviews and beauty trends, while The New York Times produces puzzle supplements with crosswords that garnered 600,000 dedicated subscribers as of 2020. These sections play a vital role in advertising, historically accounting for a significant share of periodical revenue through premium placements—such as luxury fashion ads in WSJ. Magazine, which expanded from 51 to 250 advertisers between 2008 and 2016, with fashion brands comprising the majority. Early examples like The Times supplements integrated promotional ads for international finance and trade, underscoring their commercial intent from inception. In the , supplements have evolved into hybrid print-digital offerings to counter the post-2010 shift toward online media, with publishers like providing companion websites and apps for content such as NYT Cooking (which reached 1 million subscribers by 2021 and is now bundled in multi-product subscriptions exceeding 11 million digital-only as of 2025) alongside physical editions. remains significant for due to its tactile appeal, though it captured about 80% of fashion and high-end ad spend as of the mid-2010s; by 2024-2025, digital channels have grown to represent a larger share (e.g., around 39% of broader ad spend in key markets). Overall frequency has declined amid rising newsprint costs in the 2020s, exacerbated by industry consolidations like the 2019 Gannett-GateHouse merger. This has prompted adaptations, including fewer special editions (e.g., produced 75 in 2019) and integrated digital access to sustain engagement and revenue, with post-pandemic acceleration toward AI-assisted content and video hybrids as of 2025.

Book and Academic Supplements

In , supplements to books and journals encompass a variety of formats designed to extend or correct the primary content, including appendices, errata sheets, and online companion materials. Appendices typically house supplementary details such as extended data tables, questionnaires, or procedural descriptions that are referenced in the main text but deemed too voluminous for inclusion there. Errata sheets address post-publication errors, providing corrections without necessitating a full reprint, and are often distributed as separate inserts or digital notices to uphold the integrity of scholarly works. Online companions, meanwhile, facilitate interactive or multimedia extensions, such as downloadable datasets or video demonstrations, increasingly integrated via publisher platforms. A prominent example is the Oxford English Dictionary's supplements, which began with a one-volume in 1933 to the first edition, incorporating new words and senses accumulated since 1884, and continued with a four-volume revised supplement published between 1972 and 1986, encompassing 69,300 entries and over 527,000 quotations across 5,730 pages. These supplements fulfill critical purposes in scholarly communication by delivering ancillary resources like comprehensive bibliographies, raw datasets, or methodological elaborations that bolster the main arguments without overwhelming the core narrative. In peer-reviewed journals, they enable the inclusion of non-essential yet valuable elements, such as additional figures or statistical analyses, fostering greater transparency and allowing readers to delve deeper into supporting evidence. For instance, in Nature journals, supplementary information files—often comprising datasets, extra tables, images, or multimedia—accompany select articles to provide context or validation that enhances reproducibility, though they are not required for grasping the primary conclusions and are accessible via links in the full-text PDF or abstract page. This practice underscores supplements' role in balancing conciseness with completeness, particularly in fields like sciences where voluminous data is common. Historically, supplements emerged as mechanisms to adapt static printed works to evolving knowledge, with notable developments in the for rapidly changing domains like . Loose-leaf services, introduced in the early , revolutionized legal by allowing incremental updates through replaceable pages in binders, addressing the pace of administrative and statutory revisions without full republication; publishers like Thomson Carswell exemplified this with ongoing supplements to encyclopedic digests, ensuring practitioners had current analyses alongside statutes and . Earlier precedents trace to the , as seen in the English Dictionary's initial supplements, but the loose-leaf format became a staple for enduring reference texts, mitigating obsolescence in an era of print dominance. The advent of digital technologies has transformed supplements from physical addenda to dynamic, web-based resources, often distributed as PDFs, linked databases, or interactive files to enhance global accessibility. Publishers now routinely host these materials on platforms like journal websites, where they integrate seamlessly with main articles via hyperlinks, shifting from static errata to versioned online updates. Post-2020 open-access mandates have further shaped this evolution, with funding bodies such as the (NIH) requiring data management plans that mandate public deposition of supplementary datasets in repositories, promoting immediate availability and reuse to advance principles. Similarly, the stipulates for all research outputs, including supplementary information, to ensure equitable dissemination without subscription barriers. While databases like primarily archive core journal content and primary sources, they indirectly support supplementary access by preserving digitized historical materials that complement modern digital supplements. Despite these advancements, supplements pose ongoing challenges in and , complicating scholarly workflows. Digital formats risk proliferation of outdated iterations if not properly timestamped or archived, potentially leading to discrepancies between referenced and accessed materials, as updates may occur post-citation without clear notification. Citation practices exacerbate this, with guidelines like those from the () demanding precise notation—such as appending "Supplemental material" to references and including retrieval URLs—for online extras like datasets or protocols, which are treated as integral to the archival record once published. For journal supplements, specifies "Suppl." after the issue number to denote special sections, ensuring but requiring authors to maintain consistent titling and formatting across files to reviewers and readers. These issues highlight the need for robust publisher policies to sustain supplements' reliability in an increasingly digital academic landscape.

Mathematics and Geometry

Supplementary Angles

Supplementary angles are two angles whose measures sum to exactly 180 degrees, forming a straight when adjacent. For instance, a 70° and a 110° are supplementary because 70° + 110° = 180°. This contrasts with complementary angles, which sum to 90 degrees. A key property is the linear pair theorem, which states that two adjacent forming a straight line are supplementary, as their measures add to 180 degrees. Another property arises with cut by a transversal: the consecutive interior are supplementary, a result proven using the fact that a straight line measures 180 degrees and alternate interior are equal when lines are ./01%3A_Lines_Angles_and_Triangles/1.04%3A_Parallel_Lines) Mathematically, if θ and φ are supplementary , then: \theta + \phi = 180^\circ Visually, supplementary angles appear in diagrams where two rays share a common vertex and lie opposite each other on a straight line, such as in a triangle's exterior angle extending to form a linear pair, or in polygons where adjacent angles on a straight edge sum to 180 degrees. In applications, supplementary angles aid architecture by ensuring structural alignment, such as calculating roof pitches where the angle with the horizontal and its supplement form a straight line for stability, or in bridge design to verify beam supports. In navigation, they are used in bearing calculations, where the back bearing (opposite direction) is the supplement of the forward bearing, differing by 180 degrees to determine return paths accurately. The concept originates in , formalized around 300 BCE in Euclid's Elements, Book I, Proposition 13, which proves that on a straight line sum to two right (180 degrees).

Supplemental Structures in

In advanced , supplemental structures refer to auxiliary constructs introduced to facilitate proofs, simplify computations, or extend existing frameworks. These include supplemental lines drawn in geometric diagrams to reveal congruences or parallel properties that aid in theorem verification. In linear algebra, a supplementary subspace U_2 to a subspace U_1 in a V satisfies U_1 \cap U_2 = \{0\} and U_1 + U_2 = V, enabling decompositions essential for basis extensions and projections. In algebraic contexts, such as solving systems of equations, supplemental equations are added to resolve underdetermined systems or incorporate constraints, as seen in the auxiliary equations for linear differential equations with constant coefficients. Key examples illustrate their utility across fields. In , supplemental identities arise from supplementary angles, where \sin(180^\circ - \theta) = \sin \theta, \cos(180^\circ - \theta) = -\cos \theta, and \tan(180^\circ - \theta) = -\tan \theta, providing symmetries for simplifying expressions in proofs involving sums. In , particularly sum graphs, supplementary vertices are pairs labeled j and k such that j + k = n+1 (where n is the maximum label), allowing the graph to realize all sums up to $2n and ensuring completeness in labeling schemes. These structures enhance theorem development and computational efficiency. In , the proof of by relied on supplemental elliptic curves and modular forms as auxiliary constructs to link the Fermat equation to the Taniyama-Shimura conjecture, enabling contradiction via non-modularity. In , supplemental algorithms, such as auxiliary linear programming subproblems in quadratic optimization, are integrated into software like to handle nonsmooth functions or active-set methods efficiently. Contemporary applications extend to emerging domains as of 2025. In AI-driven , supplemental datasets like CoqGym provide additional examples for models interacting with proof assistants, improving by formalizing tactics and lemmas in systems such as or . In , supplemental ancilla qubits serve as auxiliary structures for error correction codes, enabling syndrome extraction without disturbing logical qubits, as demonstrated in fault-tolerant schemes using measurements. These uses highlight how supplemental structures, including supplements in that align with derivations like \theta = 180^\circ - \phi from supplementary angle properties, continue to underpin rigorous advancements.

Economics and Law

Income and Financial Supplements

Income and financial supplements refer to additional or benefits designed to augment an individual's or household's primary , providing during periods of need or economic fluctuation. These supplements can include government-provided assistance programs, employer bonuses, or streams such as side gigs, helping to bridge gaps in from full-time . For instance, they often serve as a safety net for low- individuals facing disabilities, , or job loss, ensuring are met without relying solely on limited wages. One prominent type of is the (SSI) in the United States, which provides monthly payments to low- individuals who are aged 65 or older, blind, or disabled, with eligibility determined by limited income and resources—generally under $2,000 for an individual or $3,000 for a couple, excluding certain exemptions like a primary home. As of January 1, 2025, the maximum federal SSI benefit is $967 per month for an eligible individual and $1,450 for a couple, though some states add supplements to these amounts. Unemployment supplements, such as extended benefits under the Federal-State Unemployment Insurance , offer additional weeks of payments—up to 13 extra weeks in high-unemployment periods—beyond the standard 26 weeks of regular benefits, supporting workers involuntarily unemployed. Personal strategies for generating supplements include freelance work through platforms like or , which allow flexible earning opportunities, and investments such as dividend-paying stocks or rental properties that yield . These approaches often carry implications; in the , supplemental wages like bonuses or commissions are subject to a flat federal withholding rate of 22% for amounts up to $1 million annually, separate from regular wage taxation. The has seen increased adoption as a supplemental source in the , particularly post-pandemic, with participation rising due to job instability and trends, enabling many to earn an average of $500–$1,000 monthly from side gigs. Economically, these supplements play a crucial role in ; for example, SSI lifted approximately 2.5 million people out of in 2022 by providing essential cash support that covers about three-fourths of the federal line for a single person. They also mitigate broader impacts of recessions, as seen in the expanded use of gig work following the , which helped offset income losses for millions. Historically, the foundations of modern supplements trace back to the 1930s era, with the of 1935 establishing unemployment insurance and aid programs for the needy; SSI itself emerged in 1974 as a federalization of state for the aged, blind, and disabled, with ongoing expansions like the 2025 cost-of-living adjustment reflecting inflation to maintain . In legal contexts, a supplement refers to an or ancillary document attached to an existing or that introduces new terms, conditions, or clarifications without altering the original document's core structure. These supplements ensure that evolving circumstances, such as additional obligations or modifications, are formally incorporated while maintaining the integrity of the primary . For instance, in commercial s, a supplement might add provisions for new services or pricing adjustments agreed upon post-execution. In regulatory contexts, supplements can include amendments or addenda to statutes, regulations, or administrative rules that update or expand existing legal frameworks. For example, under the U.S. , agencies may issue supplemental rules to address new issues arising after initial , provided they follow notice-and-comment procedures. Internationally, the European Union's regulatory supplements often involve delegated acts that fine-tune directives, such as updates to environmental regulations requiring additional compliance measures. Key regulatory processes include mechanisms for amending legal claims in litigation, such as under Federal Rule of Civil Procedure (FRCP) 15, which permits parties to supplement pleadings with new facts or claims arising after the original filing, provided they relate back to the initial complaint to avoid prejudice. Courts liberally grant such supplements to promote justice, often allowing amendments once as a matter of course within 21 days of service or with leave thereafter. Enforcement actions highlight regulatory rigor; for example, in 2004, the FDA banned dietary supplements containing alkaloids after evidence linked them to serious adverse events like heart attacks and strokes, declaring them adulterated under the Federal Food, Drug, and Cosmetic Act. More recent interventions include 2024 FDA alerts and recalls for supplements contaminated with undeclared toxic substances, such as yellow oleander in tejocote root products, prompting voluntary withdrawals to protect . Challenges persist, particularly with mislabeling in regulated products, where undeclared allergens like —responsible for many FDA recalls—pose risks to sensitive consumers, often due to cross-contamination or incomplete . Studies indicate that up to 20% of supplements may contain unlisted ingredients, exacerbating health hazards and eroding trust in the market. Regulatory bodies continue to address these through targeted inspections and penalties, underscoring the need for robust verification in an industry valued at billions annually.

References

  1. [1]
    Questions and Answers on Dietary Supplements - FDA
    Feb 21, 2024 · A dietary supplement is a product intended for ingestion that, among other requirements, contains a "dietary ingredient" intended to supplement the diet.
  2. [2]
    Dietary Supplements: What You Need to Know - Consumer
    Jan 4, 2023 · Dietary supplements are products intended to supplement the diet. They are not medicines and are not intended to treat, diagnose, mitigate, ...
  3. [3]
    Dietary Supplements - FDA
    Oct 1, 2024 · FDA regulates dietary supplements under a different set of regulations than those covering conventional foods and drug products.Information on Select Dietary... · New Dietary Ingredient (NDI)
  4. [4]
    FDA 101: Dietary Supplements
    Jun 2, 2022 · Dietary supplements are intended to add to or supplement the diet and are different from conventional food. Generally, to the extent a product ...
  5. [5]
    In brief: What are dietary supplements? - InformedHealth.org - NCBI
    Jan 23, 2024 · Dietary supplements contain nutrients such as vitamins or minerals that are also found in regular foods, but in a more concentrated form and often at a higher ...Who checks the quality and... · Do you need to take dietary...
  6. [6]
    Dietary Supplement Use Among Adults: United States, 2017–2018
    Feb 19, 2021 · Among U.S. adults aged 20 and over, 57.6% used any dietary supplement in the past 30 days, and use was higher among women (63.8%) than men (50. ...
  7. [7]
    Trends in dietary supplement use among U.S. adults between 2011 ...
    Oct 23, 2025 · Use of four or more supplement products increased from 10.0 to 16.2% between 2011-2012 and 2021-2023 cycles (Ratio = 1.63 [1.35, 1.96], ...
  8. [8]
    Vitamin D - Health Professional Fact Sheet
    Jun 27, 2025 · ... Recommended Dietary Allowances and Adequate Intakes for vitamin D. These values range from 15 to 20 mcg (600–800 IU) for adults and from 10 ...Sources of Vitamin D · Vitamin D Intakes and Status · Groups at Risk of Vitamin D...
  9. [9]
    USP and Dietary Supplements ... A Return to Our Roots
    Sep 11, 2014 · ... Vitamins A & D in Cod Liver Oil. Vitamins as Nutrition. During World War II ... DSHEA in 1994. For more information about how foods are ...
  10. [10]
    The Evolution of Dietary Supplements - Blog CapsCanada
    Nov 22, 2023 · The first two vitamin supplement products hit the market in 1916: Yeast Vitamon Tablets from Mastin, which were sold directly to consumers, and ...
  11. [11]
    Dietary Supplement Health and Education Act of 1994
    An Act. To amend the Federal Food, Drug, and Cosmetic Act to establish standards with respect to dietary supplements, and for other purposes.Sec. 4. Safety of dietary... · Sec. 6. Statements of... · Sec. 7. Dietary supplement...
  12. [12]
    Global Dietary Supplements Market Size, Trends, Share 2033
    In stock Rating 4.5 Market Size in 2024, USD 197,809.8 Million ; Projected Market Size in 2033, USD 357,593.1 Million ; Market Size in 2023, USD 185,215.2 Million ; CAGR Growth Rate ...
  13. [13]
    Small Entity Compliance Guide: Current Good Manufacturing ... - FDA
    The DS CGMP rule requires persons who manufacture, package, label, or hold a dietary supplement to establish and follow current good manufacturing practice.
  14. [14]
    Role of Supplement Quality Control in Dietary Supplements
    Jun 16, 2025 · Testing raw materials is a foundational step in supplement manufacturing that ensures the purity, quality, and safety of the final product.
  15. [15]
    Dietary Supplement Manufacturing - USP Verified Mark
    The USP Dietary Supplement Verification Program can help enhance a manufacturer's competitive position and brand recognition.
  16. [16]
    Office of Dietary Supplements - Iron
    ### Summary: Use of Iron Supplements for Treating Anemia
  17. [17]
    Office of Dietary Supplements - Calcium
    ### Evidence on Calcium Supplements for Osteoporosis Treatment and Prevention
  18. [18]
    The Use of Coenzyme Q10 in Cardiovascular Diseases - PMC
    In summary, oral CoQ10 therapy (200 or 300 mg/day) for 7–14 days preoperatively could improve clinical outcomes in patients undergoing coronary and cardiac ...
  19. [19]
    Efficacy and safety of coenzyme Q10 in heart failure: a meta ...
    Oct 26, 2024 · According to the existing evidence, coenzyme Q10 reduces all-cause mortality, hospitalization for heart failure, New York Heart Association classification, and ...<|separator|>
  20. [20]
    Effect of omega-3 fatty acids on cardiovascular outcomes - PubMed
    Jul 8, 2021 · The meta-analysis showed higher RR reductions with EPA monotherapy (0.82 [0.68-0.99]) than with EPA + DHA (0.94 [0.89-0.99]) for cardiovascular ...Missing: 2023 | Show results with:2023
  21. [21]
    Vitamin A - StatPearls - NCBI Bookshelf
    Feb 19, 2025 · Vitamin A toxicity may present with various clinical symptoms, including abdominal pain, headache, nausea, and facial flushing. Laboratory ...Continuing Education Activity · Indications · Administration · Adverse Effects
  22. [22]
    The Effects of St. John's Wort and its Interactions with SSRI's - PMC
    John's Wort with SSRIs can dangerously elevate serotonin levels, potentially leading to serotonin syndrome, a serious and potentially life-threatening condition ...
  23. [23]
    St. John's wort and antidepressant drug interactions in the elderly
    We report a series of five cases of clinically diagnosed central serotonergic syndrome among elderly patients who combined prescription antidepressants with St ...<|separator|>
  24. [24]
    Probiotic Supplementation Improves the Clinical Measures of ...
    Aug 3, 2025 · In preclinical trials, probiotics modulated the gut microbiome in a way that was neuroprotective. We aim to test our hypothesis that ...
  25. [25]
    The Gut-Brain Axis and Mental Health: How Diet Shapes Our ...
    Jul 21, 2025 · Research suggests that probiotics, particularly strains like Lactobacillus and Bifidobacterium, may alleviate mental health conditions such as ...
  26. [26]
    A systematic review and dose response meta analysis of Omega 3 ...
    Aug 20, 2025 · Based on these pathways, long-chain omega-3 fatty acids (LCn-3s) are hypothesized to offer protective effects against cognitive decline.
  27. [27]
    The Relationship of Omega-3 Fatty Acids with Dementia and ...
    Mar 3, 2025 · A moderate-to-high level of evidence suggested that dietary intake of omega-3 fatty acids could lower risk of all-cause dementia or cognitive decline by ∼20%.
  28. [28]
    WHO recommendations on antenatal nutrition - BMJ Global Health
    Jul 30, 2020 · Antenatal micronutrient interventions recommended in this guideline for pregnant women and adolescent girls include daily elemental iron (30–60 mg) and folic ...
  29. [29]
    Preventing and controlling micronutrient deficiencies in populations ...
    More than 2 billion people in the world today are estimated to be deficient in key vitamins and minerals, particularly vitamin A, iodine, iron and zinc.
  30. [30]
    How Newspaper Supplements Took On Fashion Magazines | BoF
    Feb 17, 2016 · While commercial success among fashion magazines is uneven, supplements are a steady oasis of profitability. How are they doing it?
  31. [31]
    Types of newspaper - GCSE Media Studies Revision - BBC Bitesize
    These tend to have supplements close supplementsAdditional sections in a newspaper with a more specialised focus which can include magazines on culture, ...
  32. [32]
    A History of The ILN - Illustrated London News
    The founder of the Illustrated London News was Herbert Ingram, (a Daguerrotype of Herbert Ingrams) a bookseller, newsagent and printer from Nottingham.
  33. [33]
    George Leighton Prints the "Illustrated London News" Christmas ...
    The first newspaper printed in color. On December 22, 1855 the Illustrated London News issued its "Christmas Supplement." Pages [729]-736 consisted of an an ...Missing: 19th | Show results with:19th
  34. [34]
    [PDF] Associated Sunday Magazines and the Origins of Every Week
    In December 1903, publishing entrepreneur Joseph Palmer Knapp launched the. Associated Sunday Magazines (ASM) to produce a Sunday supplement magazine for.
  35. [35]
    None
    ### Summary of The Times Supplements (19th-20th Century)
  36. [36]
    Taking advantage of the print format with attractive supplements
    Print publishing is a scale business and as print advertising drops dramatically and subscribers shift to digital platforms, the economics of the business ...
  37. [37]
    OED Editions
    The Oxford English Dictionary was originally published in fascicles between 1884 and 1928. A one-volume supplement was published in 1933.First Edition · Supplements to the OED · Second Edition
  38. [38]
    Supplementary information - Nature Support
    Oct 12, 2024 · Supplementary information is additional data supplied by some authors to accompany articles published in the printed journal and is not provided for all ...
  39. [39]
    Supplementary materials need the right format - Nature
    Jul 14, 2004 · These supplementary materials typically provide either additional evidence for an article's claim or a detailed description of the methods used ...
  40. [40]
    The Legal Publishing Industry in the 20th Century and Beyond
    The first decades of the 20th century brought the introduc- tion of looseleaf services designed to cope with the rapid changes in administrative law, ...Missing: loose- leaf
  41. [41]
    Loose-leaf Legal Publications: A Dialogue - Slaw.ca
    May 10, 2022 · A loose-leaf is a publication which is deliberately not bound into a book, but rather designed to be used in a three-ring binder or other temporary binding.Missing: century supplements
  42. [42]
    Scientific Data Sharing: Policies and Access to Data
    Aug 5, 2025 · This page provides information about NIH's scientific data management and sharing policies and repositories, previously available on the NIH ...Data Management and Sharing · Data Management and... · Budgeting for Data
  43. [43]
    [PDF] Guidelines on the Implementation of Open Access to Scientific ...
    According to the ERC Scientific Council's Open Access Guidelines1: “The mission of the European Research Council (ERC) is to support excellent research in all.
  44. [44]
    Journals - About JSTOR
    JSTOR provides articles of scholarly journals in a wide variety of disciplines. Search the full text and abstracts or browse by journal title or discipline.
  45. [45]
    Supplementing Your Article With Online Material
    APA can place supplemental materials for journal articles online. This page describes what to include in your online-only supplemental material.
  46. [46]
    Supplement volume or issue - APA 7th Referencing Guide
    Oct 29, 2025 · A supplement to a particular issue of a journal: Add the abbreviation "Suppl." after the issue number to indicate you are referencing the supplement to this ...
  47. [47]
    [PDF] Guide to Supplemental Materials - SAEM
    Sep 6, 2017 · Supplemental material will be provided along with the article in the online publication of the journal, with a URL reference placed in the print ...
  48. [48]
    Definition | What are Supplementary Angles? - Cuemath
    Two angles are said to be supplementary angles if they add up to 180°. Supplementary angles form a straight angle (180°) when they are put together.
  49. [49]
    Supplementary Angles - Math is Fun
    When two angles add up to 180° we call them supplementary angles. These two angles (140° and 40°) are Supplementary Angles, because they add up...Missing: properties | Show results with:properties
  50. [50]
    Supplementary Angles | Definition, Examples & How To Find - Tutors
    Jan 11, 2023 · Complementary angles sum to exactly 90° or exactly 2 π radians. Supplementary angles are easy to see if they are paired together, sharing a common side.Definition · Angle types · Properties · Theorems
  51. [51]
    Linear Pair - Definition, Postulate, Axiom, Theorem, & Examples
    Feb 7, 2024 · Two angles are said to form a linear pair if they are adjacent (next to each other) and supplementary (measures add up to 180°.)Postulate · Perpendicular Theorem
  52. [52]
    Supplementary Angles - BYJU'S
    Supplementary angles are those angles that sum up to 180 degrees. For example, angle 130° and angle 50° are supplementary angles because sum of 130° and 50° ...
  53. [53]
    Real Life Applications of Supplementary Angles - GeeksforGeeks
    Apr 2, 2024 · Supplementary Angles in Architecture. It is used in Calculating roof angles: · It is used in designing bridges: ; Supplementary Angles in ...
  54. [54]
    Auxiliary Lines - MathBitsNotebook (Geo)
    Auxiliary lines are often used to create a triangle in a diagram or to create two congruent triangles in a diagram. Your goal is to add something to the diagram ...
  55. [55]
    [PDF] Linear Spaces
    We say that two subspaces U1 and U2 of V are supplementary in V and that U2 is a supplement of U1 in V if U1 ∩ U2 = {0} and U1 + U2 = V. Proposition 4: Let U1, ...
  56. [56]
    [PDF] Second Order Linear Differential Equations - Math
    The auxiliary equation r2 + 2r + 5 = 0 has the solutions r =- 1 2i. Thus the general solution is y = eг x ( Acos( 2x)+ Bsin( 2x)) . To solve for A and B using ...
  57. [57]
    [PDF] Trigonometric Identities Cheat Sheet
    Negative Angle Identities sin. = sin cos. = cos tan. = tan csc. = csc. Supplement Angle Identities sin. = sin cos. = cos tan. = tan csc. = csc. Page 2. •. •. •.<|control11|><|separator|>
  58. [58]
    (PDF) More Properties of Sum Graphs - ResearchGate
    Feb 10, 2017 · Clearly, [1,m] Two vertices with label j and k, in a sum graph G + (S) with n as its maximum vertex label, are called supplementary vertices if ...
  59. [59]
    Quadratic Programming Algorithms - MATLAB & Simulink - MathWorks
    To solve the auxiliary linear programming problem, the algorithm sets γ0 = M + 1, sets x0 = X , and initializes the active set as the fixed variables (if any) ...
  60. [60]
    Learning to Prove Theorems via Interacting with Proof Assistants
    In this paper, we study the problem of using machine learning to automate the interaction with proof assistants. We construct CoqGym, a large-scale dataset and ...Missing: supplemental | Show results with:supplemental
  61. [61]
    Repeated quantum error correction on a continuously encoded qubit ...
    May 5, 2016 · Quantum error correction protects quantum states by encoding a logical quantum bit (qubit) in multiple physical qubits. To be compatible with ...
  62. [62]
    SSDI and SSI benefits for people with disabilities | USAGov
    Find out if you are eligible for SSI and apply. Supplemental Security Income (SSI) is for people who have little to no income. You must also either:.
  63. [63]
    Who can get SSI | SSA
    Adults and children might be eligible for SSI if they have limited to no income and resources, and are age 65 or older or have a disability.Supplemental Security Income · Exceptions to SSI income and...
  64. [64]
    Understanding Supplemental Security Income SSI Benefits
    Effective January 1, 2025, the Federal benefit rate is $967 for an individual and $1,450 for a couple. Some States supplement the Federal SSI benefit with ...
  65. [65]
    Unemployment Insurance Extended Benefits
    The basic Extended Benefits program provides up to 13 additional weeks of benefits when a State is experiencing high unemployment.Disaster Unemployment · About UI · Trade Readjustment Allowances
  66. [66]
    How COVID-19 Has Transformed The Gig Economy - Forbes
    Dec 10, 2020 · Participation in the gig economy has grown rapidly over the past few years, and expanded exponentially since the onset of the coronavirus ...Missing: 2020s | Show results with:2020s
  67. [67]
    What is the Federal Supplemental Tax Rate? - TurboTax - Intuit
    Nov 1, 2025 · Supplemental wages of $1 million or less · Withhold at the supplemental rate of 22 percent. · Combine your regular wages for the pay period with ...
  68. [68]
    Updating SSI Would Improve the Economic Resilience of Low ...
    Mar 7, 2024 · New analysis from the Center for American Progress shows that households relying on Supplemental Security Income (SSI) face higher financial risks than non-SSI ...
  69. [69]
    Supplemental Security Income | Center on Budget and Policy Priorities
    Mar 20, 2024 · Thus, while SSI alone is not enough to lift someone living independently above the poverty line, it reduces hardship and lessens the need for ...Who Qualifies For Ssi And... · How Has Ssi Changed Over... · How Effective Is Ssi?<|control11|><|separator|>
  70. [70]
    Historical Background and Development of Social Security
    The Social Security Act was signed into law by President Roosevelt on August 14, 1935. In addition to several provisions for general welfare, the new Act ...
  71. [71]
    Addendum vs. Agreement: What's the Difference? - Icertis
    Sep 8, 2025 · An addendum modifies an existing contract without replacing it, while an agreement creates new legal obligations from scratch.
  72. [72]
    Rule 15. Amended and Supplemental Pleadings - Law.Cornell.Edu
    The rule has been revised to prevent parties against whom claims are made from taking unjust advantage of otherwise inconsequential pleading errors to sustain a ...Missing: litigation | Show results with:litigation
  73. [73]
  74. [74]
    Final Rule Declaring Dietary Supplements Containing Ephedrine ...
    Feb 11, 2004 · The Food and Drug Administration (FDA, we, our) is issuing a final regulation declaring dietary supplements containing ephedrine alkaloids adulterated.
  75. [75]
    Recalls, Market Withdrawals, & Safety Alerts - FDA
    The list below provides information gathered from press releases and other public notices about certain recalls of FDA-regulated products.Major Product Recalls · FDA.gov Archive · August Egg Company Recalls
  76. [76]
    Consultation process on novel food status - Food Safety
    Consultation process on novel food status ; High palmitic sunflower oil, 13 August 2025, Not Novel ; High purity pea (Pisum sativum) protein concentrate, 12 March ...Missing: sustainability | Show results with:sustainability
  77. [77]
    7 Must-Know EFSA Novel Food Regulation Changes for 2025
    Rating 4.8 (44) Feb 20, 2025 · The updated framework, effective February 1, 2025, will impact areas such as risk assessments, labeling, and sustainability requirements.
  78. [78]
    Nutrition - World Health Organization (WHO)
    Nutrition is a critical part of health and development. Better nutrition is related to improved infant, child and maternal health, stronger immune systems.Nutrition and Food Safety · United Nations Decade of... · 22 February 2018
  79. [79]
    FDA Launches Agency-Wide AI Tool to Optimize Performance for ...
    Jun 2, 2025 · Elsa is a large language model–powered AI tool designed to assist with reading, writing, and summarizing. ... supplements, radiation-emitting ...
  80. [80]
    Food Allergies | FDA
    Sep 22, 2025 · Of the major food allergens, milk represents the most common cause of recalls due to undeclared allergens. The five food types most often ...
  81. [81]
    Prevalence of adulteration in dietary supplements and ... - NIH
    Sep 29, 2023 · Mislabelling practices may pose health risks to the consumer as they may be ingesting far less or greater amounts of a particular ingredient ...Missing: allergens | Show results with:allergens