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Syrette

A syrette is a single-use disposable injection device consisting of a sealed, collapsible tube fitted with a hypodermic needle, designed for administering a single dose of liquid medication such as morphine without the need for a rigid syringe barrel or plunger.^[1] Developed in the late 1930s by the pharmaceutical company E. R. Squibb & Sons of Brooklyn, New York, the syrette was filed on April 15, 1939, by inventor William Erhard and issued on October 29, 1940, under U.S. Patent No. 2,219,301.^[2] Originally trademarked, the device addressed the need for a compact, easy-to-use tool for emergency medical administration, particularly in combat settings where traditional syringes were cumbersome.^[1] During World War II, the U.S. military widely adopted the morphine syrette as a standard component of soldiers' first aid kits, containing 1/2 grain (approximately 32 mg) of morphine tartrate in a hermetically sealed metal tube with a protective needle guard and wire loop to break the seal.^[3]^[2] This allowed wounded personnel to self-administer the narcotic for rapid pain relief and shock mitigation before medics could reach the battlefield, marking a significant advancement in forward casualty care.^[3]^[4] Post-war, surplus syrettes contributed to illicit morphine distribution and addiction issues among veterans, as the devices were easily obtained and repurposed.^[3] The design's simplicity influenced modern auto-injectors, and variations have been used, such as by the French Army for 10 mg subcutaneous morphine doses during combat operations in theaters like Afghanistan (as of 2016).^[5]

History

Development

The syrette was invented by E. R. Squibb & Sons, a pharmaceutical company based in Brooklyn, New York, in the late 1930s as a response to the need for a portable, single-use injection device suitable for field medical applications shortly before World War II.^[6]^[2] The device aimed to address limitations of traditional reusable glass syringes, which were fragile, difficult to sterilize in remote or combat settings, and prone to contamination from multi-use vials.^[2] Development focused on creating an expendable hypodermic unit that allowed for sterile, direct administration of medications without requiring separate syringes or complex preparation. Engineer William Erhard, working for Squibb, designed early prototypes featuring a collapsible soft-metal tube to replace rigid pistons, enabling users to deliver precise doses through simple squeezing. This innovation facilitated the injection of volumes such as 1.5 cc of liquid medication, like a 20 mg/mL morphine tartrate solution, in a compact and reliable form.^[7]^[3] On April 15, 1939, Squibb filed a patent application for the "Hypodermic Unit," which was granted on October 29, 1940, under U.S. Patent No. 2,219,301. The approval paved the way for initial production in 1940, marking the transition toward broader adoption, including by the U.S. military.^[7]^[2]

World War II Adoption

The U.S. Army adopted the morphine syrette in October 1940, following the approval of a related patent by E. R. Squibb & Sons, establishing it as a standard component in individual first aid kits to enable rapid self-administration of pain relief by wounded soldiers prior to medical evacuation.^[2] This integration marked a significant advancement in battlefield casualty care, allowing non-medical personnel to deliver controlled doses without complex equipment.^[3] As detailed in Field Manual 21-11, dated April 7, 1943, each morphine syrette contained 1/2 grain (approximately 32 mg) of morphine tartrate, equivalent to roughly 16 mg of morphine base, and was included in various kits such as the Parachute First-Aid Packet and Aeronautic First-Aid Kit (with two syrettes per kit).^[8] The manual prescribed intramuscular injection into loose skin areas like the thigh or upper arm for severe pain, with effects manifesting in 20-30 minutes, and emphasized not administering a second dose within two hours or to unconscious individuals or those with slowed respiration.^[8] To prevent overdose, protocol required pinning the empty syrette tube to the recipient's clothing, such as the collar, as a visible indicator of prior administration for subsequent caregivers.^[9] Syrettes saw widespread deployment among Allied forces, particularly U.S. medics and orderlies treating battlefield wounds during major campaigns.^[2]

Design and Mechanism

Components

The classic syrette, as issued by the U.S. military during World War II, featured a compact, disposable design optimized for rapid deployment in combat conditions. Its primary structure consisted of a flexible, sealed metal tube, typically red and white in color, measuring approximately 2.5 inches in height, 0.75 inches in width, and 0.25 inches in depth, resembling the size of a small lipstick tube for easy portability in soldiers' pockets or first-aid kits.^[3] This tube, constructed from collapsible metal to ensure hermetic sealing and single-use reliability, held about 1.5 cc of liquid medication, such as morphine tartrate, and was engineered to expel the contents via manual squeezing.^[3]^[2] Attached directly to one end of the tube was a short hypodermic needle suitable for subcutaneous injection, protected by a removable plastic cover to maintain sterility until use.^[3]^[2] A metal wire loop inserted into the hypodermic needle serves as a mechanism to pierce the internal seal and enable the flow of the drug through the needle upon activation.^[2] The exterior of the tube bore clear labeling to guide safe administration, including the drug type and dosage—such as "Morphine Tartrate 1/2 gr" (equivalent to approximately 32 mg)—along with warnings like "For Subcutaneous Use Only" and "Warning: May be habit forming," often affixed via official U.S. government narcotic stamps or printed directly on the metal surface.^[3]^[2] This labeling, sometimes in blue or white variants depending on the manufacturer like E.R. Squibb & Sons, ensured users could quickly identify and handle the device without error in high-stress environments.^[2]

Operation

The operation of a syrette begins with preparation to ensure the medication reaches the needle. The user first removes the protective transparent cap from the needle end. Next, they grasp the wire loop attached to the needle and push it to break the internal seal, allowing the liquid contents to flow toward the needle; this step requires care to fully pierce the seal without touching the needle to avoid contamination. Pull out and discard the wire.^[10] For injection, the needle is inserted subcutaneously into a fleshy area such as the upper arm or thigh, typically at a shallow 45-degree angle to reach the subcutaneous tissue without penetrating deeper muscle. The flexible tube is then squeezed firmly but steadily from the sealed end to expel the full dose, usually about 1.5 cc over 5-10 seconds, ensuring even delivery without rapid pressure that could cause discomfort. This design, relying on manual compression rather than a plunger, allows non-medical personnel to administer the injection simply and quickly in field conditions.^[10]^[3] After use, the needle is withdrawn, and the empty syrette tube is pinned to the recipient's clothing, such as the collar, to serve as a visible indicator of the dose administered, helping medics avoid accidental repeat dosing. The single-use construction of the syrette, with its sealed tube and attached needle, prevents reuse and reduces contamination risks, while the absence of a plunger simplifies the device but necessitates controlled squeezing to expel air bubbles and ensure complete delivery.^[11]^[10] Common errors during operation include over-squeezing the tube, which can lead to rapid delivery and potential tissue irritation, or failing to fully break the internal seal, resulting in leaks or incomplete dosing. Users are instructed to squeeze slowly and verify seal breakage to mitigate these issues.^[10]

Applications

Military Uses

The syrette's primary role in military medicine during World War II was the administration of morphine to alleviate severe pain from combat wounds, allowing soldiers to self-treat before medics arrived.^[3] This approach enabled rapid pain relief, reducing the incidence of shock among the wounded and thereby improving survival rates by preventing hyperventilation and circulatory collapse.^[12]^[13] Atropine syrettes were developed post-World War II as a countermeasure against nerve agent exposure in chemical warfare, with introduction around 1950 as part of the U.S. military's M5A1 protective ointment set.^[14] These syrettes delivered atropine to block the effects of agents like sarin and VX on muscarinic receptors, continuing in use through the Cold War period but were largely replaced by auto-injectors by the late 1950s. In the Persian Gulf War, atropine was issued in Mark I auto-injector kits for self- or buddy-aid.^[14] Syrettes were integrated into U.S. Army individual first aid kits during World War II, with each soldier's pouch typically containing one or two morphine syrettes alongside bandages and other essentials.^[3] Military protocols emphasized buddy-aid over self-administration to prevent overdose, requiring medics or comrades to tag the recipient with the used syrette—often pinned to clothing—to track doses and avoid excessive morphine delivery.^[12] The French military adopted 10 mg morphine syrettes for battlefield analgesia, maintaining their use through the late 20th century and into modern operations, such as in Afghanistan, as part of forward combat casualty care training.^[5] Despite these benefits, syrette use carried risks, including potential addiction, as some soldiers developed dependency on morphine during and after World War II.^[3] Overdose was another concern, particularly if multiple doses were administered without proper tracking, given that the standard 27-32 mg syrette dose could be excessive for certain patients and lead to respiratory depression.^[15]^[2]

Medical Uses

In civilian medical contexts, syrettes provided a means for rapid opioid delivery in emergency analgesia for trauma patients, particularly by paramedics in remote or disaster-stricken areas during the pre-autoinjector era of the mid-20th century.^[16] These devices allowed for quick intramuscular administration of fixed doses, such as morphine, facilitating pain relief in settings where traditional syringes were impractical due to time constraints or limited equipment.^[3] Syrettes were also employed for delivering other medications in field medicine, including antibiotics like penicillin during mid-20th-century expeditions and humanitarian efforts, where pre-filled, single-use formats enabled sterile injections in austere environments without the need for complex preparation.^[4] In British medical practice, Omnopon syrettes—an opium alkaloid mixture including morphine, papaverine, and codeine—remained part of medical kits for managing postoperative and acute pain into the 1990s, offering a compact option for opioid administration in resource-constrained scenarios.^[17]^[18] The primary advantages of syrettes in resource-limited settings stemmed from their sterile, pre-filled design, which minimized infection risks associated with multi-use syringes and ensured consistent dosing without requiring additional sterilization or mixing.^[19] However, their fixed-dose nature limited adjustability for patient-specific needs, often resulting in overdosing or underdosing concerns, which contributed to their phase-out in civilian hospitals by the 1960s in favor of more versatile disposable syringes.^[15]

Legacy

Variants

The standard U.S. military morphine syrette during World War II contained 30 mg (approximately 1/2 grain) of morphine tartrate in a 1.5 cc volume, housed in a red and white metal tube topped with a protected metal injection needle.^[15]^[3] This design allowed for rapid self-administration by wounded soldiers in field conditions. The British variant utilized Omnopon, a preparation of opium alkaloids including morphine, papaverine, and codeine, for intramuscular injection to provide mixed opioid analgesia for severe pain. These devices, often in Tubunic ampoule form, were issued as part of first aid outfits during World War II.^[20] In France, the morphine syrette featured a 10 mg dose in a closed flexible tube design similar to the Allied models, enabling subcutaneous injection for battlefield analgesia.^[5] The French Army employed this variant extensively in military and field medicine settings from World War II through the late 20th century, including in conflicts like Afghanistan, with soldiers trained in its administration during predeployment courses; as of 2016, it remained in use for combat casualty care.^[5] Atropine variants were developed post-World War II by the U.S. and Allied forces in the 1950s specifically for countering nerve agent exposure, containing atropine sulfate to counteract cholinergic effects.^[21] These syrettes were distributed in military kits, often paired with pralidoxime (2-PAM) to reactivate inhibited acetylcholinesterase, forming early antidote combinations like the Mark I kit precursors.^[22]

Modern Successors

The development of autoinjectors in the late 1950s marked a significant evolution from the World War II-era syrette, introducing spring-loaded mechanisms that enabled hands-free, automatic drug delivery without the need for manual squeezing.^[16] Pioneered by engineer Stanley Sarnoff at Rodana Research around 1956, these devices addressed the syrette's limitations in high-stress scenarios by simplifying administration to a single activation step.^[16] The U.S. military's Mark I Nerve Agent Antidote Kit (NAAK), introduced in the mid-1950s, exemplified this advancement as a dual-autoinjector system delivering atropine and pralidoxime chloride for nerve agent exposure, allowing rapid intramuscular injection through clothing.^[21] Subsequent iterations further refined these technologies, with the Nerve Agent Antidote Kit (NAAK) standardizing pre-filled, automatic delivery of atropine and oximes in military stockpiles by the 1970s.^[16] This evolved into the DuoDote autoinjector in the early 2000s, a compact dual-chamber device that combines both antidotes in one unit, reducing the number of injections required from two to one and minimizing user steps during emergencies. These systems prioritized reliability in chemical defense scenarios, ensuring consistent dosing even for self-administration by potentially compromised individuals.^[23] In the civilian sector, syrette-inspired autoinjector technology influenced the creation of the EpiPen in the mid-1970s, originally adapted from military designs like the ComboPen for nerve agent antidotes.^[24] Developed by Sheldon Kaplan at Survival Technology, the EpiPen provided a single-use, spring-activated mechanism for intramuscular epinephrine delivery, offering convenient self-administration for anaphylaxis treatment and gaining FDA approval in 1987.^[24] This portability mirrored the syrette's field-ready design while enhancing accessibility for non-military users.^[25] Autoinjectors offered key advantages over syrettes, including reduced risk of user error through automated delivery, deeper intramuscular injection for faster absorption compared to the syrette's subcutaneous method, and integrated needle shielding or retraction to prevent needlestick injuries post-use.^[16]^[5]^[26] These features improved efficacy in urgent situations, such as through-clothing injection without manual force.^[16] By the 1980s and 1990s, syrettes had been largely phased out in U.S. military protocols in favor of autoinjectors like the NAAK, though their legacy endures in modern portable drug delivery systems used in global health initiatives for vaccines and emergency medications.^[27]^[28]

References

[1]
SYRETTE Definition & Meaning - Merriam-Webster
The meaning of SYRETTE is a small collapsible tube fitted with a hypodermic needle for injecting a single dose of a medicinal agent (such as morphine).
[2]
Drugs, Chemicals and Biological Stains Morphine Tartrate
The patent for Squibb's developed “Hypodermic Unit” was filed on 15 April 1939. Soon after the patent for the Syrette had been approved in October of the ...
[3]
Morphine Syrette | DEA Museum
Each kit included morphine syrettes that allowed the wounded to self-administer narcotics before medics could arrive on the scene.
[4]
https://imss.org/2018/05/a-note-from-the-collection-hypodermic-needles-syrettes-and-ampoules-from-the-world-war-ii-era/
[5]
The French Syrette of morphine for administration to combat casualties
Apr 1, 2016 · The Syrette is a device for injecting liquid through a needle, almost similar to a syringe, except that it has a closed flexible tube, instead ...
[6]
E. R. Squibb | Pharmaceuticals, Drug Development, Industrial ...
Nov 1, 2025 · E. R. Squibb was a U.S. chemist and pharmaceutical manufacturer who developed methods of making pure and reliable drugs and founded a ...
[7]
US2219301A - Hypodermic unit - Google Patents
4. A hypodermic unit comprising a collapsible soft-metal tube having an integrally extruded, readily-pierceable blind end, a hypodermic needle having a base ...
[8]
[PDF] FM 21-11 - FIRST AID FOR SOLDIERS - Wikimedia Commons
Morphine tartrate syrette (!2 grain) (may be added to this kit upon direction of the commanding officer when the military circumstances indicate its need).
[9]
[PDF] Fighting a War Without Rifles: Deconstructing the Image of the ...
One such signal was morphine syrettes pinned to a soldier's clothing to ... US Army could only run into harm's way for so long before they had to be ...<|separator|>
[10]
[PDF] FM 21-11 - Ibiblio
The coat flap or shirt tail may be used as a sling by pinning it to the coat or shirt or by punching a hole through the lower edge of the flap or tail and ...<|separator|>
[11]
The painkiller of battlefields | Newsletter Archive | History Tours
Rating 4.9 (609) Squibb & Sons pharmaceutical company from Brooklyn, New York developed an expendable device, a so-called syrette, for the administration of morphine. The ...
[12]
None
### Summary on Syrette Use by Corpsmen, Morphine for Pain and Shock Prevention
[13]
[PDF] Opioids in the Military: A Soldier's Disease
During World War II, the syrette was devel- oped by Squibb, a pharmaceutical company, to allow for the administration of controlled doses of morphine to wounded ...Missing: 1940 | Show results with:1940
[14]
[PDF] MEDICAL ASPECTS of CHEMICAL and BIOLOGICAL WARFARE
Although in ancient times medics carried the caduceus into battle to signify the neutral, humanitarian nature of their tasks, they have never been immune to the ...
[15]
History | AMEDD Center of History & Heritage
(gr. ?) amounts of morphine put up inArmy-issue syrettes were too large for many patients, even when only single injections were used.
[16]
How the autoinjector changed the world - Kindeva Drug Delivery
Jul 2, 2024 · Prior to the development of the autoinjector in the late 1950s, military personnel used a product called a syrette. Its appearance was similar ...
[17]
Out of Our Comfort Zone: Pain Relief in a Crisis
Omnopon is a powerful opiod analgesic and is used for moderate to severe pain. ... This example was sold after 1978: it is no longer used in Britain and has been ...
[18]
[PDF] Falklands war 25TH anniversarY - ResearchGate
Omnopon (30mg syrette). Those in whom evacuation was unavoidably delayed ... to those planned by the British Army Medical Services, with surgical ...
[19]
Prefilled syringes for immunoglobulin G (IgG) replacement therapy
The benefits of ready-to-use prefilled syringes include provision of drugs in a closed system, accurate dosing, sterility assurance, and reduced risk of ...
[20]
Medicinal preparation, liquid solution, morphine (Omnopon)
Two single dose Tubunic ampoule-syringes of 'Omnopon' branded morphine, containing morphine, papaverine and codeine. Part of a first aid outfit supplied for ...Missing: syrette british
[21]
EMERGENCY USE OF ATROPINE SYRINGE / SYRETTE / AMPULE ...
Jan 22, 2020 · U.S. ARMY NERVE GAS EXPOSURE -- EMERGENCY USE OF ATROPINE SYRINGE / SYRETTE / AMPULE 98374.Missing: WWII | Show results with:WWII
[22]
Nerve Agent Treatment - Autoinjector Instructions - CHEMM
Mark 1 Kit contains: Atropine autoinjector. 2 mg in 0.7cc. Pralidoxime autoinjector (2-PAM). 600 mg in 2cc. Injection site selection:
[23]
The history of the syringe - Exchange Supplies
Syrettes were a standard part of the 1st aid kit carried by U.S. medical orderlies in World War 2. Used Syrettes were pinned to the collar of a casualty in ...Missing: portable | Show results with:portable
[24]
A Short History of the U.S. Army Medical Research Institute of ...
Feb 23, 2023 · Both atropine and 2-PAM were eventually formulated for use in autoinjector systems, first in the Mark I Nerve Agent Antidote Kit (NAAK) as two ...<|separator|>
[25]
(PDF) Drug delivery systems for chemical defense
Insufficient relevant content. The provided text from https://www.researchgate.net/publication/262912154_Drug_delivery_systems_for_chemical_defense contains no specific information about the evolution from syrettes to autoinjectors, timelines for Mark I NAAK, advantages, replacement of syrettes, or phasing out dates. It only includes metadata about authors and unresolved citations/references.
[26]
Inventing Life-Saving Epinephrine Auto-Injectors | Lemelson
Jan 11, 2022 · Prior to the invention of the auto-injector, medicine needed to be drawn from a separate vial into a syringe and then injected. This worked ...Missing: Syrette | Show results with:Syrette
[27]
Sheldon Kaplan - National Inventors Hall of Fame®
Traditionally, epinephrine was drawn from a vial with a syringe, a method both time consuming and error prone. Sheldon Kaplan designed the EpiPen at Survival ...
[28]
Improving the safety of disposable auto-injection devices - AAPS Open
Oct 18, 2018 · However, there are many reports of safety-related issues affecting auto-injectors and pen injectors, due to usability deficits. To minimize this ...
[29]
Cold War Era NBC Injectors and Decontamination Kits
Jan 24, 2019 · This kit was called the M5A1. In 1959 the M5A2 was created, it replaced the Atropine Syrette with an Atropine Auto Injector but it was not ...
[30]
Evolution of First Aid Training in the British Army | Military Medicine
Jan 25, 2021 · In 1943, the morphine syrette was introduced into the first aid outfit of armored fighting vehicles.18 This consisted of a needle attached to a ...