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Alpha particle

An alpha particle is a type of consisting of two protons and two neutrons tightly bound together, making it identical to the of a atom, and it is emitted during the process from the nuclei of certain heavy radioactive elements such as and . These particles carry a positive charge of +2 elementary charges due to the two protons and have a mass approximately four times that of a proton, resulting in relatively low speeds of about 5-7% the when emitted with typical kinetic energies around 4-9 MeV. The discovery of alpha particles is credited to Ernest Rutherford, who in 1899, while studying radiation from uranium compounds, identified alpha rays as a distinct form of positively charged radiation separate from the negatively charged beta rays, building on earlier observations of uranium's radioactivity by Henri Becquerel in 1896. Rutherford further characterized alpha particles between 1907 and 1911 through experiments at the University of Manchester, collaborating with Hans Geiger and Ernest Marsden to scatter them off thin gold foil, which unexpectedly revealed the dense, positively charged nucleus at the atom's center and revolutionized atomic theory. These scattering experiments demonstrated that alpha particles could penetrate matter but were deflected by atomic nuclei, providing key evidence for the nuclear model of the atom. Alpha particles exhibit high ionizing power because of their double charge and substantial mass, which allows them to strip electrons from atoms along straight-line paths in materials, creating dense ionization tracks but limiting their penetration depth to just a few centimeters in air or stopped by a sheet of paper. In nuclear physics, alpha decay reduces the atomic number of the parent nucleus by two and the mass number by four, serving as a mechanism for unstable heavy isotopes to achieve greater stability, and it plays a crucial role in stellar nucleosynthesis and the decay chains of actinides. Beyond natural radioactivity, alpha particles are harnessed in applications such as particle accelerators for nuclear research, targeted alpha therapy for cancer treatment due to their potent but short-range damage to cells, and ionization in smoke detectors using sources like americium-241.

Definition and Properties

Name and Notation

The term "alpha particle" was coined by physicist Ernest Rutherford in 1899 to classify the types of ionizing radiation emanating from uranium compounds. In his seminal paper, Rutherford described experiments showing that uranium radiation consisted of two distinct components based on their differing absorption rates in air and thin metal foils: the less penetrating, more easily absorbed rays were designated as alpha rays, while the more penetrating ones were called beta rays. This nomenclature reflected the sequential order of discovery, with "alpha" drawn from the first letter of the Greek alphabet (α), symbolizing its position as the initial type identified. Subsequent research revealed the true nature of alpha particles. In 1909, Rutherford, collaborating with Thomas Royds, conducted experiments using radon gas (a source of alpha emission) confined in a glass tube with a thin mica window, allowing alpha particles to enter an evacuated outer tube. By observing the characteristic helium spectral lines appearing over time in the outer tube, they conclusively demonstrated that alpha particles are doubly ionized helium atoms—specifically, the helium-4 nucleus comprising two protons and two neutrons. This composition distinguishes alpha particles from neutral helium atoms, which include two orbiting electrons; the alpha particle exists as a bare, positively charged with a +2 due to the absence of electrons. In notation, alpha particles are standardly represented by the Greek letter α or as ^4_2\mathrm{He}^{2+}, where the superscript 4 denotes the (total nucleons) and the subscript 2 the (protons), emphasizing their identity as nuclei in an ionized state. This symbolism is widely used in equations describing and scattering processes.

Physical Characteristics

An alpha particle, denoted as ^4_2\mathrm{He}^{2+}, consists of two protons and two neutrons tightly bound together, exhibiting a mass of approximately 4 atomic mass units, or precisely $6.644657 \times 10^{-27} . This mass arises from the combined masses minus a small deficit. The particle carries a positive charge of +2e, equivalent to $3.204 \times 10^{-19} C, due to the two protons. As a composite , the alpha particle has a total of 0, resulting from the paired spins of its constituent fermions (protons and neutrons) in the . Its exceptional stability stems from the strong , which binds the nucleons into a compact, low-energy configuration that overcomes the electrostatic repulsion between the protons. In typical emissions, alpha particles achieve velocities of 5% to 7% the , rendering their behavior non-relativistic and allowing approximations for many interactions. Quantum mechanically, the alpha particle is described as a composite entity whose reflects the closed-shell structure of the nucleus, with nucleons occupying filled orbitals in the , contributing to its ground-state symmetry and inertness.

Production Mechanisms

Alpha Decay

Alpha decay is a radioactive process in which an unstable with Z greater than spontaneously emits an —a nucleus consisting of two protons and two neutrons—to attain a more stable configuration by reducing its by 4 and by 2. This emission is energetically favorable for heavy nuclei due to the imbalance in their proton-to-neutron ratio, which helps correct by lowering the repulsion between protons. The decay rate, or partial for alpha emission, follows the empirical Geiger-Nuttall law, which correlates the logarithm of the T_{1/2} inversely with the of the 's E_\alpha: \log_{10} T_{1/2} = a - \frac{b}{\sqrt{E_\alpha}}, where a and b are constants fitted for specific isotopic chains; this relationship arises from the tunneling probability and has been verified across a wide range of alpha energies from about 4 to 9 MeV. The underlying mechanism, proposed by in 1928, involves the alpha particle being pre-formed as a clustered structure within the parent due to strong nuclear interactions, followed by its escape through quantum mechanical tunneling past the formed by electrostatic repulsion. Classically, the alpha particle lacks sufficient energy to surmount this barrier, which extends to radii of about 30-50 fm for typical decay energies, but quantum effects allow a non-zero probability P \approx e^{-2G}, where G is the Gamow factor over the barrier; the overall decay constant \lambda is then \lambda = f P, with f representing the frequency of assaults on the barrier. This theory not only explains the exponential dependence of on energy but also predicts the near-monoenergetic spectrum of emitted alphas, corresponding to transitions to states. The general alpha decay equation is ^{A}_{Z}\mathrm{X} \to ^{A-4}_{Z-2}\mathrm{Y} + ^{4}_{2}\alpha + Q, where Q is the total disintegration energy (Q-value) shared as between the daughter nucleus and alpha particle, determined by the mass difference via Q = [m(\mathrm{X}) - m(\mathrm{Y}) - m(\alpha)] c^2. A representative example is the decay of in its natural series: ^{238}_{92}\mathrm{U} \to ^{234}_{90}\mathrm{Th} + ^{4}_{2}\alpha + 4.27\,\mathrm{MeV}, with a half-life of 4.468 billion years, initiating a chain of eight alpha decays that ultimately yields lead-206. Another key example is radium-226, which decays as ^{226}_{88}\mathrm{Ra} \to ^{222}_{86}\mathrm{Rn} + ^{4}_{2}\alpha + 4.87\,\mathrm{MeV}, with a half-life of 1600 years, releasing gas as the daughter product. The rate of alpha decay is further modulated by the parent nucleus's internal structure, including shell effects where "magic numbers" of protons or s (2, 8, 20, 28, 50, 82, 126) fill closed shells, enhancing and stability, thus suppressing decay probabilities compared to nearby non-magic nuclei. For instance, nuclei approaching magic number 126, as in the region, exhibit systematically longer partial half-lives for alpha emission due to reduced clustering and assault frequencies.

Other Natural and Artificial Sources

Alpha particles are produced in ternary , a process that occurs alongside in the splitting of heavy nuclei such as and plutonium-239. This rare phenomenon accounts for approximately 0.2 to 0.4% of events, or about 1 in 300 to 400 cases, and involves the emission of a long-range alpha particle with an average of around 16 MeV. In Earth's atmosphere, secondary alpha particles arise from spallation reactions induced by high-energy primary protons in cosmic rays colliding with atmospheric nuclei, such as nitrogen-14, which can yield an alpha particle alongside other fragments like protons and isotopes. These interactions contribute to the flux of at various altitudes, with production rates depending on the incident spectrum and atmospheric composition. Within the Sun's core, alpha particles form as the primary product of the proton-proton chain, a series of fusion reactions beginning with p + p \rightarrow ^2\mathrm{H} + e^+ + \nu_e and culminating in the net transformation of four protons into one ^4_2\mathrm{He} nucleus, accompanied by two positrons and two electron neutrinos. This process releases energy that powers the star and populates the solar corona with alpha particles, which are then carried outward in the plasma, comprising up to 5% of its ionic content by number./21%3A_Radioactivity_and_Nuclear_Chemistry/21.09%3A_Nuclear_Fusion_-_The_Power_of_the_Sun) Particle accelerators provide a controlled artificial source of alpha particles, with cyclotrons accelerating ions to energies typically in the 10–30 MeV range for applications like medical isotope production, while linear accelerators and synchrotrons can achieve beam energies up to several GeV for high-energy physics experiments probing . Rare natural sources include potential alpha particle generation from lightning-induced photonuclear reactions, where high-energy gamma rays from electrical discharges may eject alpha particles from atmospheric or terrestrial nuclei, though such events remain experimentally challenging to quantify. Additionally, alpha particles from the of terrestrial radon isotopes, such as emanating from uranium-rich soils and rocks, represent a ubiquitous environmental source, with concentrations varying by and .

Energy and Interaction Properties

Energy Spectrum

Alpha particles emitted during radioactive decay possess kinetic energies typically ranging from 4 to 9 MeV, with specific values determined by the decaying nucleus. This range arises from the Q-value of the alpha decay process, which represents the total energy released and is shared between the alpha particle and the recoiling daughter nucleus. Due to the two-body nature of alpha decay, where energy and momentum are conserved, alpha particles from a given isotope are emitted as discrete, monoenergetic lines rather than a continuous spectrum. For instance, the primary alpha decay branch of americium-241 yields particles with an energy of 5.486 MeV. Although fundamentally monoenergetic, the observed energy spectrum of alpha particles can show slight broadening. This arises primarily from the of the daughter , which imparts a small to the alpha particle in the center-of-mass frame, and from environmental effects such as thermal motion of the parent or energy straggling within the source material. These effects result in linewidths on the order of tens to hundreds of keV, depending on the experimental setup, but do not obscure the discrete character of the emission lines. For alpha particle energies below 10 MeV, relativistic effects are negligible, as the particle velocities remain much less than the speed of light (v/c ≈ 0.07 at 10 MeV). The non-relativistic approximation for velocity is thus appropriate: v = \sqrt{\frac{2E}{m}} where E is the kinetic energy and m is the mass of the alpha particle (approximately 4 u). Alpha particle energies are precisely measured using magnetic spectrometry, which deflects charged particles in a magnetic field to separate them by momentum-to-charge ratio, or time-of-flight techniques, which calculate energy from velocity over a known flight path. These methods achieve resolutions sufficient to resolve fine structure in decay schemes, with magnetic spectrometers offering high precision for absolute energy calibration.

Absorption and Penetration

Alpha particles primarily interact with matter through , losing energy via collisions with atomic electrons. This process is described by the for , which quantifies the energy loss per unit path length, -\frac{dE}{dx}. For non-relativistic alpha particles, an approximation of the formula is \frac{dE}{dx} \approx \frac{4\pi z^2 e^4 N Z}{m_e v^2}, where z = 2 is the , e is the , N is the of electrons, Z is the of the medium, m_e is the , and v is the particle velocity. This interaction results in a continuous energy degradation, with the rate increasing as the particle slows down due to its decreasing velocity. The limited of alpha particles arises from their high , leading to ranges on the order of a few centimeters in air and microns in denser materials. For example, a typical 5 MeV alpha particle travels approximately 3.5 cm in air at but only about 40–44 μm in . In solids like aluminum, the range is even shorter, typically tens of micrometers. These distances highlight the particles' low penetrative ability, which depends on the medium's (proportional to Z and density) and the initial of the particle. Due to their large (approximately 7300 times that of an ), alpha particles experience minimal deflection from multiple , traveling in nearly straight paths until they stop. Effective shielding requires only thin barriers, such as a sheet of or the outer layer of (about 70 μm thick), which halts alpha particles before they can reach living tissue. A characteristic feature of their energy deposition is the , where the -\frac{dE}{dx} reaches a maximum near the end of the range, depositing the highest dose just before the particle comes to rest. This peak underscores the localized nature of alpha particle absorption, contrasting with more penetrating types.

Effects and Interactions

Biological Effects

Alpha particles exhibit high linear energy transfer (LET), typically around 100 keV/μm, which results in dense ionization along their short tracks in biological tissue. This dense ionization pattern leads to clustered damage, including double-strand breaks in DNA that are particularly difficult for cellular repair mechanisms to mend. Due to their high LET, alpha particles have a (RBE) of 10-20 times that of or gamma for inducing cancer, reflecting their greater potential to cause effects like . This elevated RBE underscores the disproportionate health impact of alpha emitters compared to low-LET radiations at equivalent absorbed doses. The primary health risks from alpha particles arise from internal exposure via or of alpha-emitting radionuclides, rather than external irradiation, as their limited confines external effects to superficial skin layers. Key examples include progeny (such as polonium-218 and polonium-214), which attach to aerosols and deposit in the , emitting alpha particles that irradiate and elevate risk. Similarly, or of , often present in or contaminated sources, targets tissue and contributes to through localized alpha irradiation. In , the biological impact of alpha particles is quantified using in grays (), which measures energy deposited per unit mass, but for assessing risk, the in sieverts () incorporates a factor of 20 to account for their high RBE. This emphasizes that alpha particle exposure is 20 times more biologically damaging than low-LET for effects. Notable case studies highlight these risks: Residential exposure to gas and its alpha-emitting daughters has been linked to thousands of cases annually, prompting the U.S. Environmental Protection Agency (EPA) to recommend when indoor levels exceed 4 /L (148 Bq/m³). Historical exposure to , an alpha emitter, as experienced by through chronic internal contamination during her research, resulted in severe health consequences including .

Material and Electronic Effects

Alpha particles interact with materials primarily through and, to a lesser extent, collisions, leading to structural damage in solids such as used in applications. In fuels like (UO₂), from actinides such as generates high-energy alpha particles and heavy recoil nuclei, with the latter initiating displacement cascades that displace atoms from lattice sites, creating vacancies and interstitial defects. These cascades result in amorphization and lattice expansion over time, contributing to material degradation. Additionally, the atoms produced by alpha particles accumulate in bubbles, causing volumetric swelling of up to 0.5% over long-term storage periods (tens to hundreds of years) in high-burnup fuels, with potential for cracking. In electronic devices, alpha particles induce single-event upsets (SEUs) by depositing charge along tracks in semiconductors, particularly in cells of and . This charge collection generates transient currents that can exceed the critical charge threshold (typically 10-50 fC in modern nodes), flipping bit states from 0 to 1 or vice versa without permanent damage. The involves the alpha particle's path creating dense electron-hole pairs (up to 10⁴ pairs per μm in ), which diffuse and are swept into nearby junctions by electric fields, causing voltage spikes. In space environments, SEU error rates from alpha particles and related secondaries reach approximately 10⁻⁹ errors per bit per day in unprotected , though terrestrial rates from packaging sources are lower, around 10⁻¹⁰ to 10⁻¹¹ per bit per day. Notable examples include soft errors in systems from cosmic ray-induced alphas and, historically, from and impurities in chip packaging materials, which emit alphas that penetrate passivation layers and upset memory bits, as observed in early DRAM failures during the 1970s. Mitigation strategies encompass error-correcting codes () like Hamming or BCH codes to detect and correct single-bit errors, alongside the use of low-alpha semiconductor packaging to reduce impurity-related emissions by over 90%. These approaches have significantly lowered SEU vulnerability in high-reliability applications such as .

Historical Development

Discovery

In 1896, French physicist discovered that salts spontaneously emit invisible capable of penetrating black paper and exposing photographic plates, marking the initial observation of natural radioactivity. Building on this, in 1899, , working at , classified the emissions from radioactive elements into two types based on their penetration and ionization properties: alpha rays, which strongly ionize air but are stopped by thin sheets of material, and beta rays, which are more penetrating. This distinction arose from experiments measuring the deflection of rays in electric and magnetic fields, with alpha rays showing positive charge and greater mass compared to the negatively charged beta rays. By 1903, Rutherford and his collaborator proposed that alpha particles were doubly ionized helium atoms ( nuclei), a supported by spectroscopic evidence from and Soddy showing that helium's characteristic spectrum appeared in gases evolved from decay. Their experiments involved collecting emanation from radium compounds and observing the helium lines through prism , confirming the link between alpha emission and helium production. A pivotal experiment began in 1909 under Rutherford's direction at the , where and bombarded thin gold foil with alpha particles from a radioactive source and detected their scattering patterns using a fluorescent screen. Surprisingly, while most particles passed straight through, a small fraction deflected at large angles—up to 180 degrees—indicating that atoms contain a tiny, dense, positively charged nucleus surrounded by mostly empty space, as Rutherford detailed in his 1911 analysis. To facilitate precise detection in such studies, in 1908, Geiger developed the first under Rutherford's guidance to count individual alpha particles by measuring ionization pulses in a , with refinements by 1911 enabling quantitative scattering measurements.

Key Experiments and Advances

In 1919, conducted the first artificial by bombarding gas with alpha particles from a radioactive source, resulting in the reaction ^{14}\mathrm{N} + ^4\mathrm{He} \rightarrow ^{17}\mathrm{O} + ^1\mathrm{H}, where hydrogen nuclei (protons) were ejected and detected as long-range particles. This experiment, performed at the , marked the beginning of controlled nuclear reactions and provided direct evidence for the composition of atomic nuclei. Building on empirical observations of , developed a quantum mechanical theory in , explaining the emission process through tunneling of the alpha particle through the of the daughter nucleus. Gamow's model quantitatively predicted decay rates by calculating the transmission probability of the barrier, aligning with the Geiger-Nuttall law and enabling predictions of half-lives for various isotopes without adjustable parameters beyond known nuclear radii. This theoretical advance shifted understanding of from classical to quantum phenomena, influencing subsequent nuclear models. During the 1930s, the , refined by researchers like Patrick M. S. Blackett, allowed visualization of alpha particle paths as dense, straight ionization tracks in supersaturated vapor, facilitating studies of and interactions with matter. These tracks revealed details of energy loss and deflection, confirming Rutherford's nuclear model through photographic evidence of close encounters. By the 1950s, the invention of the by extended this capability to high-energy regimes, where alpha particles produced bubble trails in superheated liquids, enabling precise measurements of decay products and interactions in experiments. Bubble chambers proved superior for resolving short tracks and multiple particles, contributing to early studies of high-energy alpha-induced reactions. In modern , alpha particles accelerated to MeV energies serve as probes in transfer reactions to elucidate structure, particularly in exotic isotopes produced at facilities like the (FRIB) at , the successor to the National Superconducting Cyclotron Laboratory. Alpha transfer reactions, such as (p, α) or (α, t), selectively populate specific states, providing spectroscopic factors that reveal configurations and correlations in neutron-rich nuclei. These experiments, often combined with reaction theory models, have advanced understanding of drip-line nuclei and astrophysical processes.

Antimatter Analog

Anti-Alpha Particle Properties

The anti-, also known as the antinucleus of and denoted as \bar{\alpha} or ^{4}\bar{\mathrm{He}}^{2-}, is the counterpart to the conventional alpha particle. It is composed of two antiprotons and two antineutrons bound together in a stable configuration by the , mirroring the structure of the helium-4 nucleus but with antiparticles. This antinucleus possesses identical mass to its matter analog, with a rest of approximately 3727 MeV/c^2, but exhibits an opposite of -2e, where e is the magnitude. Upon encountering ordinary , the anti-alpha particle undergoes , converting the rest masses of itself and the interacting particles into energy, primarily through the production of pions and subsequent gamma rays, yielding about 7.45 GeV total energy release. The stability of the anti-alpha particle parallels that of the alpha particle, remaining unbound from spontaneous decay due to its of roughly 28 MeV, which prevents dissociation under normal conditions. As a composite boson with zero spin, the anti-alpha particle shares the potential for Bose-Einstein condensation in dense, low-temperature plasmas, where quantum statistical effects could lead to macroscopic occupation of the , analogous to predictions for bosonic antinuclei in theoretical models. It is important to distinguish the anti-alpha particle, which is the charged antinucleus, from the neutral antihelium atom formed by combining this antinucleus with two positrons to achieve electrical neutrality.

Production and Detection

Anti-alpha particles, also known as antihelium-4 nuclei, are generated in high-energy heavy-ion collisions at particle accelerators, including the (RHIC) at and the (LHC) at . The experiment at RHIC first produced and observed them in gold-gold (Au-Au) collisions at a center-of-mass energy per pair of \sqrt{s_{NN}} = 200 GeV, where antiprotons and antineutrons formed bound states through coalescence mechanisms in the collision aftermath. Similarly, the at the LHC has detected anti-alpha particles in lead-lead (Pb-Pb) collisions at \sqrt{s_{NN}} = 5.02 TeV, with occurring via analogous processes in the dense medium created by the collisions. More recently, as of 2025, the reported the first measurement of (anti)alpha in proton-proton collisions at \sqrt{s} = 13.6 TeV, providing insights into production in smaller systems. These production events are exceedingly rare, with approximately 18 antihelium-4 nuclei identified by the STAR collaboration in 2011 from data encompassing nearly one billion collision events. Production cross-sections for anti-alpha particles are on the order of $10^{-6} relative to antiproton yields, reflecting the low probability of multiple antinucleons coalescing into a stable bound state. Follow-up measurements by ALICE in the 2010s and 2020s, including data from LHC Run 2 and Run 3, have yielded additional detections, with the cumulative total across experiments exceeding tens of events due to improved statistics, though scarcity persists. Detection of anti-alpha particles employs magnetic spectrometers to determine through curved trajectories in a solenoidal , paired with time-of-flight (TOF) systems to measure and infer from the relation m = p / v. In both the and detectors, particle tracking is performed using time projection chambers (TPCs), which provide specific energy loss (dE/dx) measurements for charge and identification, confirming the anti-alpha's charge of -2e (with the negative sign determined by the direction of ) and near 3.73 GeV/c^2. signatures upon interaction with detector material—producing multiple pions and gamma rays—serve as confirmatory evidence of their composition, distinguishing them from matter counterparts. Significant challenges in detection stem from the low flux of anti-alpha particles, necessitating analysis of enormous datasets to achieve statistical significance, and from beam-induced backgrounds that can mimic signals through particle misidentification. Contamination risks are mitigated via rigorous kinematic cuts and background subtraction techniques. Advances in the 2020s, including upgrades to the ALICE detector's inner tracking system and TOF arrays, have improved resolution and efficiency, enabling more precise yield extractions in recent Pb-Pb and pp runs.

Applications

Scientific and Technological Uses

Alpha particles find widespread application in ionization-based detection technologies, most notably in smoke detectors. These devices utilize (Am-241), a potent alpha emitter with a of 432.2 years, to ionize air molecules within a sensing chamber, thereby establishing a small electrical between electrodes. When smoke particles enter the chamber, they attach to the ions, reducing the current and triggering an alarm. This mechanism has been the global standard for ionization smoke detectors since the 1970s, with over 90% of such units worldwide incorporating trace amounts of Am-241 (typically 0.3 micrograms per unit). In neutron generation, alpha particles from sources like plutonium-239 or americium-241 interact with beryllium-9 via the (α, n) reaction, producing fast neutrons with energies up to 11 MeV. Plutonium-beryllium (PuBe) sources, in particular, are compact and yield neutron fluxes of 10^6 to 10^8 neutrons per second, making them ideal for industrial applications such as oil well logging, where neutrons probe formation porosity and fluid content by measuring backscattered gamma rays or neutrons. These sources have been employed since the mid-20th century in borehole tools to assess hydrocarbon reservoirs, offering portability and reliability in harsh subsurface environments. Radioisotope thermoelectric generators (RTGs) harness the heat from alpha decay of plutonium-238 (Pu-238) to power deep-space missions. Pu-238 undergoes alpha decay with a half-life of 87.7 years, releasing approximately 0.56 watts of thermal power per gram, which is converted to electricity via thermocouples exploiting the Seebeck effect. Iconic examples include the three RTGs on each Voyager spacecraft, providing about 470 watts at launch in 1977 and sustaining operations over 45 years, and the Multi-Mission RTG on the Curiosity rover, delivering 110 watts to enable surface exploration on Mars since 2012. This technology ensures reliable, long-term power independent of sunlight, critical for missions beyond the inner solar system. In , alpha serves as a precise method for identification, particularly in . Detectors, such as surface barrier diodes, measure the discrete energies of alpha particles (typically 4-9 MeV) emitted during , allowing differentiation of like , , , and their daughters based on unique spectral peaks. This technique is essential for U-series of geological samples, enabling age determinations from thousands to hundreds of thousands of years by analyzing disequilibrium in chains within corals, speleothems, and sediments. High-resolution spectra achieve energy resolutions below 20 keV, facilitating accurate quantification even in low-activity matrices.

Medical and Therapeutic Applications

Alpha particles have found significant applications in medical and therapeutic contexts, particularly in , where their high (LET) enables precise targeting of cancer s while limiting exposure to surrounding healthy s. Targeted alpha (TAT) utilizes alpha-emitting radionuclides conjugated to biomolecules, such as antibodies or peptides, to deliver cytotoxic directly to tumor sites. This approach leverages the short path length of alpha particles, typically 50-100 μm in , which corresponds to a few diameters, allowing for effective of micrometastases without widespread . In alpha immunotherapy, radionuclides like actinium-225 (²²⁵Ac) or bismuth-213 (²¹³Bi) are linked to monoclonal antibodies to form bioconjugates that selectively bind to tumor-associated antigens, facilitating the killing of cancer cells through dense ionization that induces irreparable double-strand DNA breaks. Clinical studies have demonstrated the efficacy of ²¹³Bi-labeled compounds in treating hematologic malignancies and solid tumors, with rapid tumor uptake and minimal off-target effects due to the short half-life of ²¹³Bi (46 minutes). Similarly, ²²⁵Ac-based therapies, with a longer half-life of 10 days, have shown promising results in prostate cancer trials, where PSMA-targeted ²²⁵Ac-PSMA-617 achieved significant PSA reductions in over 50% of patients with metastatic castration-resistant prostate cancer. These therapies exploit the high relative biological effectiveness (RBE) of alpha particles, estimated at 3-20 compared to beta particles, which enhances cell-killing efficiency even in hypoxic tumor environments. A notable example is dichloride (²²³RaCl₂, marketed as Xofigo), approved by the FDA in 2013 for treating symptomatic bone metastases in patients with castration-resistant . In the phase 3 ALSYMPCA trial, ²²³RaCl₂ extended median overall survival by 3.6 months (14.9 months vs. 11.3 months with ) and delayed skeletal-related events, with a favorable safety profile showing reduced rates of and pathologic fractures. Administered as six intravenous injections over 12 weeks, it mimics calcium uptake in of bone metastases, delivering alpha emissions locally to eradicate cancer cells while sparing due to the short range. A 2025 real-world update (data cutoff October 2024) confirms sustained efficacy, with low rates of secondary malignancies and fractures observed over up to 95 months of follow-up. Brachytherapy using alpha emitters represents another targeted application, particularly for localized , where implantable sources deliver radiation directly to the tumor. The Diffusing Alpha-emitters Radiation Therapy (DaRT) system employs radium-224 seeds that release short-lived alpha-emitting daughters (e.g., ²¹²Pb and ²¹²Bi) to create a high-dose region within the , achieving complete response rates in preclinical models and ongoing phase 1/2 trials for intermediate-risk disease. This method confines the alpha emissions to the implant site, minimizing exposure to adjacent organs like the and . Compared to beta-emitting radiotherapies, alpha particles offer superior precision due to their short range (40-100 μm) and high LET (80-100 keV/μm), which results in a higher RBE and reduced damage to healthy , as the is deposited densely over a limited path rather than diffusely over millimeters. This is particularly advantageous for treating small tumor clusters or micrometastases, where particles' longer (up to 10 mm) can irradiate non-target cells, increasing . However, challenges persist, including the of daughter nuclei, which can detach from the targeting due to high (up to 100 keV), potentially redistributing radioactivity and causing unintended . Additionally, supply limitations for radionuclides like ²²⁵Ac, produced via or generator methods, constrain scalability, with global demand exceeding production capacity for widespread clinical use. Ongoing addresses these through improved strategies and alternative production routes.