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Anhydrous

In chemistry, anhydrous refers to a substance that contains no water, typically describing compounds from which all water molecules—especially water of crystallization—have been removed, resulting in a dry, water-free form.^[1]^[2] The term originates from the Greek words an- (without) and hydor (water), emphasizing the complete absence of moisture.^[3] This state can apply to solids, liquids, or gases, and is distinct from hydrated forms where water is chemically bound.^[1] Notable examples of anhydrous compounds include pure sulfuric acid (H₂SO₄), which is a viscous, water-free liquid,^[4] and hydrogen chloride (HCl) as a gas, in contrast to its aqueous solution known as hydrochloric acid.^[1] Another common instance is anhydrous copper(II) sulfate (CuSO₄), a white powder obtained by heating the blue pentahydrate form (CuSO₄·5H₂O) to drive off the water molecules.^[1] Anhydrous ammonia (NH₃), a colorless gas stored under pressure, is widely used as a fertilizer and refrigerant due to its high nitrogen content without dilution by water.^[5] Anhydrous conditions are essential in numerous chemical processes to prevent unwanted side reactions, as water can hydrolyze sensitive reagents or alter product yields.^[1] For instance, Grignard reagents (organomagnesium compounds) must be prepared and used under strictly anhydrous environments, often with drying agents like calcium chloride, to avoid decomposition.^[1] Similarly, reactions such as the Wurtz coupling require anhydrous solvents to facilitate coupling of alkyl halides.^[1] Preparation typically involves heating hydrates, vacuum drying, or storage in desiccators to maintain the anhydrous state, underscoring its role in precise synthetic chemistry.^[1]

Definition and Etymology

Definition

In chemistry, an anhydrous substance is defined as a compound or material that contains no water molecules, either in free form or bound as water of crystallization or hydration.^[1] This term is most commonly applied to solids and liquids where water has been completely removed, ensuring the substance is entirely dry and free from moisture. The absence of water is critical in many chemical processes to avoid interference with reactions or alterations in properties. It is essential to distinguish "anhydrous" from related terms such as "anhydride," which specifically denotes a compound formed by the removal of water from two acid molecules, resulting in a structure where two acyl groups are linked by an oxygen atom.^[6] Similarly, "dried" refers to a process or state involving the removal of water, but it often implies partial rather than complete elimination, whereas anhydrous strictly indicates the total lack of water content as determined by analytical methods like water determination assays.^[7] While primarily used in chemical contexts, the term anhydrous extends to other fields, such as food science, where it describes products like anhydrous milk fat, a concentrated form of butter oil with all water removed for extended shelf life and use in processed foods.^[8] In water-sensitive reactions, maintaining anhydrous conditions is vital to prevent hydrolysis or other moisture-induced side effects.

Etymology

The term "anhydrous" derives from the Greek prefix an- ("without" or "not") and hýdōr ("water"), combined with the English adjective-forming suffix -ous, literally meaning "without water."^[9]^[10] This etymological construction reflects its application to substances or conditions devoid of water, particularly in scientific contexts, and is a modern coinage rather than a direct borrowing from ancient Greek anúdros (used for waterless lands).^[9] The word first appeared in English in 1819, initially in chemical literature to describe water-free compounds during the burgeoning field of analytical chemistry in the early 19th century.^[11] By 1819, it was documented in the encyclopedia Pantologia, marking its entry into broader scientific discourse as a precise descriptor for dehydrated materials.^[11] This timing aligned with intensified research on hydrates—crystalline compounds incorporating water molecules—prompting the need for a standardized term to contrast them with their waterless forms. Prominent chemists like Jöns Jacob Berzelius contributed to the term's adoption through their meticulous studies of salts and acids in the 1810s and 1820s; for instance, Berzelius referenced anhydrous boracic acid in his quantitative analyses, emphasizing water's role in compound stability and composition. Such work, focused on determining atomic weights and reaction stoichiometries, popularized "anhydrous" in European chemical journals and treatises. By the early 20th century, the term had evolved into a cornerstone of analytical chemistry nomenclature, routinely applied in laboratory protocols, reagent specifications, and crystallographic descriptions to ensure reproducibility in water-sensitive experiments. Its widespread use reflected the discipline's maturation, from Berzelius-era empiricism to standardized international conventions like those in the IUPAC system.

Properties and Importance

Physical Properties

Anhydrous substances exhibit distinct physical characteristics compared to their hydrated counterparts, primarily due to the absence of water molecules in their crystal lattice. These forms are frequently more hygroscopic, readily absorbing atmospheric moisture to revert to hydrated structures, which can affect their handling and storage. For instance, anhydrous copper(II) sulfate manifests as a white, crystalline powder, in contrast to the vibrant blue crystals of its pentahydrate form, highlighting differences in color, texture, and overall state arising from the lack of coordinated water. In terms of thermal behavior, anhydrous compounds often display higher melting points than their hydrated analogs because the stabilizing influence of water molecules is absent, potentially leading to decomposition risks at elevated temperatures rather than clean melting. For example, anhydrous sodium sulfate has a melting point of 884 °C, while its decahydrate melts incongruently at approximately 32 °C, illustrating how hydration lowers thermal stability.^[12] This absence of water can also increase volatility in certain cases, as the compound lacks the binding effect of hydration to moderate phase transitions. Regarding solubility and density, anhydrous forms typically possess higher densities due to the compact packing without interstitial water, such as anhydrous sodium sulfate at 2.67 g/cm³ versus 1.46 g/cm³ for the decahydrate. Their solubility profiles are altered, often showing greater affinity for non-aqueous solvents owing to reduced polarity from the lack of water, though reactivity with moisture remains elevated, necessitating careful environmental control.^[12]

Chemical Significance

Anhydrous conditions play a critical role in water-sensitive reactions by preventing hydrolysis and unwanted side reactions that could decompose reactive intermediates. In organometallic synthesis, such as the preparation and use of Grignard reagents, the presence of even trace water leads to rapid protonation and quenching of the organometallic species, thereby inhibiting the desired nucleophilic additions or couplings.^[13] Similarly, organolithium compounds require strictly anhydrous environments to maintain their reactivity, as water initiates exothermic decomposition pathways that compromise reaction selectivity and safety.^[14] These conditions ensure the integrity of highly polar organometallics, enabling efficient carbon-carbon bond formations essential to synthetic chemistry. The impact of anhydrous environments extends to reaction kinetics, where the absence of water facilitates faster rates, higher yields, and greater control over polymerization processes. For instance, in Suzuki-Miyaura cross-coupling polymerizations, anhydrous setups minimize homocoupling defects and side reactions, allowing room-temperature initiation with enhanced molecular weight control and reduced polydispersity.^[15] In interfacial polymerization of polyamides, eliminating water prevents hydrolysis of reactive intermediates, leading to thinner, more uniform membranes with improved permeability and selectivity compared to hydrated systems.^[16] Overall, these conditions shift kinetics toward productive pathways, avoiding chain termination or branching induced by moisture. In analytical chemistry, anhydrous conditions are vital for achieving precise stoichiometry and reliable data in techniques like non-aqueous titrations and spectroscopy. Non-aqueous titrations employ anhydrous solvents such as glacial acetic acid to sharpen endpoints for weak acids or bases that ionize poorly in water, enabling accurate quantification without dilution effects or interference from autoionization.^[17] For spectroscopy, particularly NMR and IR, anhydrous solvents eliminate broad water signals that overlap with analyte peaks—such as the 4.7-5.0 ppm HOD resonance in NMR or the 3400 cm⁻¹ O-H stretch in IR—thus ensuring high-resolution spectra for structural elucidation.^[18] This precision is indispensable for determining trace impurities or confirming reaction completeness in sensitive analyses.

Anhydrous Substances by Physical State

Solids

Anhydrous solids are crystalline or amorphous materials devoid of water molecules in their lattice structure, distinguishing them from hydrates by the absence of bound water that would otherwise influence their physical and chemical behavior.^[19] These solids often exhibit high hygroscopicity, readily absorbing atmospheric moisture due to their affinity for water, which enables their widespread use as desiccants and reagents in chemical processes.^[20] Prominent examples include phosphorus pentoxide (P₄O₁₀), a white amorphous powder or crystalline solid that serves as a powerful desiccant by reacting exothermically with water to form phosphoric acids.^[20] Another key instance is silica gel, composed of porous silicon dioxide (SiO₂), which functions through physical adsorption in its non-crystalline, high-surface-area structure to trap water molecules.^[21] Anhydrous sodium sulfate (Na₂SO₄), a white hygroscopic crystalline solid, acts as a mild drying agent by incorporating water into its lattice to form hydrates.^[22] These solids' utility as desiccants stems from their capacity to absorb moisture, with silica gel demonstrating an adsorption rate of 25-30% of its weight under typical conditions, while phosphorus pentoxide offers superior removal of trace water in gases and liquids.^[23]^[20] Anhydrous sodium sulfate can bind up to 10 molecules of water per formula unit, forming visible hydrate clumps that indicate saturation.^[22] Regeneration of these desiccants, such as heating silica gel to drive off absorbed water, allows reuse without altering their core structure.^[19]

Liquids

Anhydrous liquids, particularly organic solvents, are essential in chemical processes where even trace amounts of water can interfere with reactions or stability. These liquids are purified to achieve ultra-low water levels, often through distillation over drying agents like molecular sieves or calcium hydride, followed by storage under inert atmospheres to prevent moisture ingress. Common examples include glacial acetic acid, which is a corrosive, high-purity liquid used as a solvent and reagent, exhibiting enhanced reactivity due to its minimal water content.^[24]^[25] Anhydrous diethyl ether serves as a flammable, volatile solvent prized for its ability to dissolve a wide range of organic compounds, while dry tetrahydrofuran (THF) is a polar aprotic solvent that coordinates effectively with organometallic species. In laboratory settings, these solvents are standardized to water contents typically below 10-50 ppm to ensure reliability in sensitive applications. Water levels are precisely measured using Karl Fischer titration, a coulometric or volumetric method that quantifies trace moisture by reacting it with iodine in a methanol-based medium.^[26]^[27]^[28] Without water, these anhydrous liquids often display increased viscosity and reactivity, as moisture typically stabilizes molecular structures or moderates intermolecular forces. For instance, glacial acetic acid's viscosity rises in its pure form compared to aqueous dilutions, contributing to its distinct handling characteristics, while the absence of water in diethyl ether and THF heightens their utility in processes intolerant to hydrolysis. These solvents are commonly stored in sealed containers to maintain their anhydrous state.^[29]^[25]^[30]

Gases

Anhydrous gases refer to gaseous compounds or mixtures that are free of water vapor, ensuring their purity and stability for various applications. These gases are typically handled in high-purity forms to prevent reactions with trace moisture that could lead to corrosion or unwanted chemical changes in storage and delivery systems.^[31]^[32] A prominent example is anhydrous ammonia (NH₃), a colorless gas with a pungent odor, widely used as a nitrogen source in fertilizers due to its high nitrogen content of approximately 82%. Unlike aqueous ammonia solutions, which are diluted and less concentrated, anhydrous ammonia is stored and transported as a liquefied gas under pressure, allowing for efficient application in agriculture.^[33]^[34]^[35] Another key example is anhydrous hydrogen chloride (HCl), a colorless gas distinguished from aqueous hydrochloric acid (commonly known as muriatic acid), which is HCl dissolved in water. The pure gaseous form exhibits greater reactivity and volatility, influencing its use in chemical synthesis, while the aqueous version forms a solution with different acidity and handling requirements. Anhydrous HCl is supplied in compressed cylinders to maintain its dry state.^[36]^[37]^[38] Dry nitrogen (N₂) serves as an inert purge gas, valued for its chemical inactivity and ability to displace oxygen and moisture in industrial processes. In its anhydrous form, nitrogen prevents oxidation and corrosion by maintaining a low-moisture environment, and it is commonly stored in high-pressure cylinders for reliable delivery. The distinction between dry nitrogen and moist variants lies in the latter's potential to introduce water vapor, which can alter reactivity in sensitive applications.^[39]^[40]^[32]

Preparation and Handling

Drying Techniques

Drying techniques are essential processes for removing water or moisture from substances to achieve anhydrous states, preventing unwanted hydrolysis or side reactions in chemical preparations. These methods vary based on the substance's physical state, thermal stability, and sensitivity to air or other contaminants, with the goal of minimizing residual water content to levels often below 10 ppm for high-purity applications.^[30] Among common methods, heating under vacuum lowers the boiling point of water, facilitating its evaporation without decomposing heat-sensitive compounds; for instance, anhydrous forms of salts like lanthanum bromide are prepared by stepwise vacuum heating to expel hydration water.^[41] Use of desiccants involves adding porous materials that selectively adsorb water molecules; molecular sieves, such as 3Å types, are particularly effective for organic solvents, reducing water content to sub-ppm levels by trapping water in their uniform pores.^[30] Distillation with drying agents, exemplified by the Dean-Stark apparatus, employs azeotropic removal where water is separated as a distinct layer in a sidearm trap during reflux, ensuring anhydrous distillate for solvents like toluene.^[42] Advanced techniques address limitations of basic methods, particularly for thermally labile materials. Freeze-drying, or lyophilization, involves freezing the substance and then sublimating ice under vacuum, preserving structure in heat-sensitive biological or pharmaceutical compounds while achieving anhydrous conditions.^[43] For solvents, column-based purification passes the liquid through packed beds of activated alumina, which adsorbs water and peroxides, yielding ultra-dry solvents suitable for air-sensitive reactions; systems like those with alumina columns can routinely deliver solvents with water levels under 1 ppm.^[44] Specialized equipment enhances the efficiency and safety of these techniques, especially under inert conditions. Desiccators are sealed glass vessels containing desiccants like silica gel or calcium chloride to maintain low humidity, allowing cooled samples to reach anhydrous states post-heating without reabsorption of atmospheric moisture.^[45] Schlenk lines, consisting of a dual manifold for vacuum and inert gas, enable manipulations like drying under nitrogen or argon, preventing oxidation during transfer of moisture-sensitive anhydrous compounds.^[46]

Storage Methods

Maintaining the anhydrous state of substances during storage requires strict protocols to prevent moisture ingress, typically achieved through sealed containers and controlled atmospheres. General practices include using sealed glass ampoules for long-term preservation of sensitive compounds, which can be filled with inert gases such as nitrogen (N₂) or argon (Ar) to exclude air and water vapor.^[47] Schlenk flasks, equipped with stopcocks for evacuation and inert gas flushing, are commonly employed for storing air- and moisture-sensitive reagents under an inert atmosphere, allowing for repeated access without contamination.^[48] Additionally, desiccator cabinets containing desiccants like silica gel provide a dry environment for hygroscopic materials, ensuring low humidity levels (often below 10%) to inhibit water absorption.^[49] Storage methods vary by physical state to accommodate specific properties. For anhydrous liquids, such as solvents, Sure/Seal bottles with crimp-sealed septa and elastomer liners are standard, enabling puncture under inert gas for dispensing while minimizing oxygen and moisture exposure; these systems have demonstrated moisture uptake as low as 1-2 ppm over weeks of repeated use.^[50] Anhydrous gases are stored in high-pressure cylinders designed for compressed gases, often equipped with integrated driers or purifiers to maintain dryness and prevent corrosion or reaction with residual water.^[51] Solids, being particularly hygroscopic, are kept in vacuum-sealed pouches or containers to remove air and achieve a low-pressure environment that reduces water vapor interaction, with transfer to desiccators for ongoing protection.^[52] To ensure ongoing purity, periodic monitoring via Karl Fischer titration is essential, as this method accurately quantifies trace water content (down to ppm levels) in stored anhydrous substances, allowing detection of any ingress and timely re-drying if needed.^[53] This quality control step, performed after initial drying techniques, helps verify that storage conditions remain effective over time.^[54]

Applications

Laboratory Uses

In laboratory settings, anhydrous substances are essential for conducting moisture-sensitive reactions in organic synthesis, particularly those involving highly reactive organometallic compounds. Grignard reagents, formed from alkyl or aryl halides and magnesium in anhydrous diethyl ether, require strictly dry conditions to prevent hydrolysis by trace water, which would otherwise decompose the reagent and halt the reaction.^[55] Similarly, organolithium compounds, prepared by reacting lithium metal with organic halides in anhydrous solvents like hexane or THF, demand water-free environments to avoid quenching by proton sources, ensuring their nucleophilic or basic properties remain intact for carbon-carbon bond formations.^[55] These reactions exemplify the chemical significance of anhydrous conditions in enabling precise control over reactivity. Anhydrous substances also play critical roles in analytical chemistry, serving as pure references for spectroscopic and quantitative analyses. For instance, anhydrous hydrogen chloride gas is used in Fourier-transform infrared (FTIR) spectroscopy to study rotational-vibrational transitions, where its dry state avoids interference from water absorption bands in the 2600–3100 cm⁻¹ region, allowing clear observation of HCl's characteristic doublet peaks. Anhydrous solids, such as sodium carbonate, function as certified secondary standards in pharmaceutical and chemical assays, providing baseline purity without hydrated impurities that could skew results in techniques like titration or chromatography.^[56] Modern laboratory tools like gloveboxes facilitate the handling of air-sensitive anhydrous materials by maintaining an inert atmosphere, typically purged with nitrogen or argon to exclude oxygen and moisture. These enclosed systems allow researchers to manipulate reactive anhydrous compounds, such as metal alkyls or phosphazenes, without exposure to ambient air, supporting experiments in fields like materials science and catalysis.^[57]

Industrial Applications

Anhydrous ammonia serves as a primary nitrogen source in industrial fertilizer production, accounting for approximately 88% of U.S. production and imports dedicated to this purpose.^[58] Unlike aqueous ammonia solutions, which are typically used in water treatment or as chemical precursors, anhydrous ammonia is applied directly as a liquified gas injected subsurface into soil at depths of 4–10 inches using specialized equipment such as pressurized tanks, metering systems, and injection knives.^[58]^[59] This method, often performed by trained specialists, enables efficient nutrient delivery to crops, with annual U.S. usage reaching approximately 12 million short tons as of the early 2020s to enhance soil fertility and crop yields.^[60] In pharmaceutical manufacturing, anhydrous solvents like acetonitrile play a critical role in the synthesis of active pharmaceutical ingredients (APIs), particularly for moisture-sensitive compounds such as oligonucleotides and peptides, where water can trigger hydrolysis or side reactions that lower yields and purity.^[61] By maintaining dry conditions, these solvents facilitate higher reaction efficiency by minimizing interferences from residual moisture.^[62] This approach is essential in large-scale production to ensure consistent product quality and economic viability. The food industry utilizes anhydrous milk fat (AMF), produced by concentrating cream to 35–40% fat via centrifugation, followed by phase inversion, further concentration to 99.5% fat, and vacuum dehydration to reduce moisture to ≤0.1%, for applications in confectionery, baking, and recombination of dairy products.^[63] Short-path distillation of AMF further refines it into fractions with tailored melting points and fatty acid profiles, enabling customized textures in products like chocolate and ice cream while preserving nutritional value. Additionally, anhydrous citric acid functions as a preservative in foods and beverages by acting as an antimicrobial agent and pH control agent, inhibiting bacterial growth and oxidation in items such as soft drinks, jams, and canned goods, in compliance with FDA regulations for safe usage levels.^[64] Emerging applications include anhydrous hydrogen in polymer electrolyte membrane (PEM) fuel cells, where the gas must achieve a minimum purity of 99.97% with water content limited to ≤5 µmol/mol to prevent membrane dehydration, catalyst poisoning, or ice formation that could impair performance.^[65] Standards such as ISO 14687 and SAE J2719 specify these dry gas requirements (>99.999% in high-end systems) to support efficient energy conversion in vehicles and stationary power systems, driving advancements in clean energy infrastructure.^[65]

Safety Considerations

Hazards

Anhydrous substances often exhibit heightened reactivity due to the absence of water, leading to risks such as exothermic reactions upon contact with moisture. For instance, phosphorus pentoxide (P₄O₁₀) reacts violently with water to produce phosphoric acid and significant heat, generating fire and explosion hazards.^[66] This exothermicity can intensify combustion of nearby materials, posing severe dangers in uncontrolled environments. Additionally, anhydrous ethers, such as diethyl ether, are highly flammable liquids with a low flash point of -45°C, forming explosive vapor-air mixtures and unstable peroxides upon exposure to air.^[67] Toxicity represents another critical hazard for certain anhydrous compounds, particularly those that are gases or highly corrosive. Anhydrous hydrogen fluoride (HF) causes severe, painful burns through deep tissue penetration, leading to liquefactive necrosis and systemic fluoride toxicity that can result in cardiac arrhythmias and hypocalcemia.^[68] Even brief contact with its vapors or liquid can produce life-threatening effects, with dermal exposures as small as 2.5% of body surface area potentially fatal if untreated.^[69] Similarly, anhydrous ammonia is a corrosive gas that irritates and burns the respiratory tract upon inhalation, causing swelling of the larynx, pulmonary edema, and chronic issues like bronchitis in repeated exposures.^[70] Stability concerns arise with air-sensitive anhydrous solids, which may undergo spontaneous ignition. Alkali metals, such as sodium and potassium in elemental form, are pyrophoric and can self-ignite upon brief exposure to air, especially in finely divided states, due to rapid oxidation.^[71] This reactivity classifies them as significant fire hazards under occupational safety standards.^[72]

Precautions

When handling anhydrous materials, operations should be conducted in a well-ventilated fume hood to minimize exposure to vapors or dusts, as recommended in standard laboratory safety protocols.^[73] Personal protective equipment (PPE) is essential, including chemical-resistant gloves, safety goggles or face shields, and laboratory coats to protect against splashes and contact.^[74] For air-sensitive anhydrous compounds, such as organometallics or certain solvents, inert atmosphere techniques must be employed using nitrogen or argon gas, Schlenk lines, or gloveboxes to prevent reactions with moisture or oxygen.^[75] In the event of spills, anhydrous materials require specific emergency measures to avoid exacerbating reactions. Dry absorbents like sand, vermiculite, or commercial sorbents should be used immediately to contain and absorb the spill, particularly for water-reactive substances where water-based cleanup could generate heat or gases.^[76] For anhydrous acids, neutralization can be performed cautiously with bases such as sodium bicarbonate or soda ash, while monitoring pH to ensure complete reaction without over-neutralization; bases may be neutralized with acids like citric acid.^[76] Evacuation of the area and ventilation activation are critical first steps, followed by professional cleanup if the spill exceeds small-scale incidental releases. Regulatory compliance is vital for safe management of anhydrous substances. The Occupational Safety and Health Administration (OSHA) provides specific guidelines under 29 CFR 1910.111 for the storage and handling of anhydrous ammonia, including requirements for corrosion-resistant containers, safety relief valves vented upward, and separation from ignition sources in storage areas.^[77] All anhydrous chemicals must be labeled according to the Globally Harmonized System (GHS), featuring pictograms, signal words (e.g., "Danger"), hazard statements, and precautionary statements on containers to communicate risks and safe handling instructions.^[78]

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Feb 22, 2014 · Schlenk Techniques The Schlenk flask is an ordinary round-bottom flask with a sidearm with a stopcock (greased!). You can connect this sidearm ...
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6 Working with Chemicals | Prudent Practices in the Laboratory ...
Containers of other substances stored over dry ice for extended periods ... HF should be stored in tightly closed polyethylene containers. HF attacks ...
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[PDF] the-schlenk-line-survival-guide.pdf
Schlenk flasks are reaction vessels used for air- and moisture-sensitive chemistry. They are typically fitted with a side arm with a Teflon tap or ground glass ...
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Reagents & Solvents: How to Store Reagents
How to Store Reagents · thermally stable · not volatile. · degrade extensively when exposed to the laboratory atmosphere for an extended period of time.
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Sure/Seal™ Packaging System
### Summary: Storage of Anhydrous Solvents Using Sure/Seal Bottles and General Practices for Air-Sensitive Reagents
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Compressed Gases | Environmental Health & Safety (EHS)
Incompatible gas cylinders such as hydrogen (flammable) and oxygen (oxidizer) should be stored at least 20ft apart. A firewall (partition) five feet high with a ...
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[PDF] CHEMICAL HYGIENE PLAN
A Schlenk or high vacuum line consists of a glass manifold that has several stopcocks, valves or openings in addition to a connection to a vacuum source ( ...
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https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_%28Organic_Chemistry%29/Aldehydes_and_Ketones/Synthesis_of_Aldehydes_and_Ketones/Grignard_and_Organolithium_Reagents
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[PDF] Measuring Water in Anhydrous Solvents (Chlorobenzene, MIBK ...
Apr 6, 2020 · Karl Fischer titration method. This method uses coulometric or volumetric titration to measure trace amounts of water in a sample. The Karl ...
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Grignard and Organolithium Reagents - Chemistry LibreTexts
Jan 22, 2023 · ... reagents excellent nucleophiles and useful reactants in synthesis ... Grignard reagents, organolithium reagents can be used as strong bases.
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https://www.epa.gov/system/files/documents/2023-03/Anhydrous%20Ammonia%20Supply%20Chain%20Profile.pdf
[59]
Glovebox, Gas, & Solvent System Applications for Lab | Inert
Gloveboxes provide a controlled environment for working with highly reactive, air-sensitive, or hazardous chemicals, ensuring operator safety and experiment ...
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None
### Summary of Industrial Use of Anhydrous Ammonia in Fertilizers
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[PDF] DRAFT: AP-42 CH 9.2.1 - Fertilizer Application
Anhydrous ammonia, which supplies nitrogen, is the only gaseous fertilizer used. Farmers usually hire trained specialists to apply the 5.7 million tons of ...
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How Reagent Purity Impacts API Manufacturing for Oligonucleotides ...
May 2, 2025 · Critical reagents include phosphoramidite building blocks, activators, oxidizing/sulfurizing agents, and anhydrous solvents like acetonitrile.
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[PDF] Process development for the synthesis at industrial scale of active ...
anhydrous solvents (ACN, EtOAc and chloroform) were used to eliminate possible interferences ... yield of the synthesis was increased from a 21 % to a 28 ...
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ANHYDROUS MILK FAT (AMF) AND BUTTER OIL
Anhydrous milk fat and butter oil are products consisting of more or less pure milk fat. Although they are modern industrial products, they have ancient ...Anhydrous Milk Fat (amf) And... · Production Of Amf · Amf Refining
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Citric Acid - cfsanappsexternal.fda.gov
CITRIC ACID ; ANTIMICROBIAL AGENT, ANTIOXIDANT, ENZYME, FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, LEAVENING AGENT, PH CONTROL AGENT, SEQUESTRANT, SOLVENT OR ...
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[PDF] Hydrogen Fuel Quality Specifications for Polymer Electrolyte Fuel ...
Nov 2, 2016 · One of these key standards addresses hydrogen fuel quality specifications for polymer electrolyte membrane (PEM) fuel cells in road vehicles.
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ICSC 0545 - PHOSPHORUS PENTOXIDE - Inchem.org
This generates fire and explosion hazard. Reacts violently with water. This produces phosphoric acid. Attacks many metals in the presence of water. Formula ...
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DIETHYL ETHER - CAMEO Chemicals - NOAA
Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. A mixture of liquid air ...
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Hydrofluoric Acid Burns - StatPearls - NCBI Bookshelf
Jul 17, 2023 · Hydrofluoric acid is highly toxic and damaging. It penetrates into deep tissue causing liquefactive necrosis and release of cellular products.
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Hydrofluoric Acid and Fluorides | California Poison Control System
Mar 20, 2010 · Severe toxicity and death have been described after dermal exposures as small as 2.5% total body surface area with anhydrous (100%) HF. Other ...
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Ammonia Solution, Ammonia, Anhydrous | NIOSH - CDC
Ammonia is a toxic gas or liquid that, when concentrated, is corrosive to tissues upon contact. Exposure to ammonia in sufficient quantities can be fatal.<|separator|>
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[PDF] Combustible Metals - Pitt Safety
Jun 3, 2016 · Some heat spontaneously in air and must be stored and handled under a nonreactive liquid or gas. Chips and other fine particles ignite easily, ...<|control11|><|separator|>
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[PDF] Hazard Classification Guidance for Manufacturers, Importers ... - OSHA
Examples of potential pyrophoric chemicals include alkali metals in elemental form (e.g., lithium, powdered aluminum, magnesium), organometallic compounds ...
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Working with Chemicals - Prudent Practices in the Laboratory - NCBI
Review the MSDS and the manufacturer's label before using a chemical in the laboratory or hood. Observe the permissible exposure limit, threshold limit value, ...
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[PDF] School Chemistry Laboratory Safety Guide - CDC
Wear disposable gloves, as provided in the laboratory, when handling haz- ardous materials. Remove the gloves before exiting the laboratory. Wear a full-length ...
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[PDF] Handling Air-Sensitive Reagents Technical Bulletin AL-134
Air-hydrolysis in a hood is appropriate only for the last traces of material that remain after a Sure/Seal bottle has been emptied as completely as possible via ...<|separator|>
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Guide for Chemical Spill Response
Neutralize acids with soda ash or sodium bicarbonate. Bases can be neutralized with citric acid or ascorbic acid. Use pH paper to determine when acid or base ...
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https://www.osha.gov/sites/default/files/publications/OSHA3636.pdf
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[PDF] Hazard Communication Standard: Labels and Pictograms - OSHA
All hazardous chemicals shipped after June 1,. 2015, must be labeled with specified elements including pictograms, signal words and hazard and precautionary ...