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Biological process

A biological process is the execution of a genetically encoded biological module or program, consisting of all the steps required to achieve a specific biological objective through the action of particular gene products or macromolecular complexes, often in a regulated temporal sequence.^[1] These processes encompass a wide range of activities essential to the functioning and survival of living organisms, from molecular interactions within cells to complex interactions at the organismal level.^[2] Key examples of biological processes include metabolism, which involves the chemical reactions that sustain life by converting nutrients into energy; growth and development, where organisms increase in size and differentiate into specialized structures; reproduction, enabling the propagation of genetic material; and responsiveness, allowing organisms to detect and react to environmental changes such as light or touch.^[3] In humans, additional vital processes encompass respiration for gas exchange, digestion for breaking down food, circulation for nutrient transport, and excretion for waste removal, all of which maintain homeostasis and support overall physiological integrity.^[3] Studying biological processes is fundamental to biology, as it reveals how living systems operate, adapt, and evolve, providing insights into the origins of life and the mechanisms underlying health and disease.^[4] For instance, disruptions in these processes, such as altered metabolic pathways, contribute to conditions like cancer or diabetes, informing targeted therapies and preventive strategies.^[2] Advances in fields like genomics and systems biology rely on mapping these processes to predict cellular responses and develop biotechnological applications, such as drug design and personalized medicine.^[2]

Definition and Fundamentals

Definition

A biological process refers to the execution of a genetically encoded biological module or program, consisting of a series of molecular events or transformations accomplished by one or more biological entities, such as gene products, leading to a specific outcome essential for the functioning of a living system.^[5] This encompasses coordinated actions at various scales, from subcellular interactions to organism-level responses, that contribute to the maintenance, growth, or adaptation of biological entities.^[6] The concept of a biological process was formalized in the context of systems biology through the Gene Ontology (GO) project, a collaborative initiative launched in 1998 by the Model Organism Databases to standardize gene function annotations across species. The GO's inaugural publication in 2000 established the biological process ontology as one of three core domains—alongside molecular function and cellular component—providing a structured vocabulary for describing these dynamic phenomena and facilitating computational analysis of genomic data. This formalization addressed the need for unified terminology in the post-genomic era, enabling cross-species comparisons and integration of diverse biological knowledge. At its foundation, a biological process involves key components: inputs, such as substrates, ligands, or environmental signals that initiate the sequence; mechanisms, including enzymatic catalysis, binding events, or regulatory interactions that drive the transformations; and outputs, such as metabolic products, altered cellular states, or transmitted signals that achieve the intended biological objective.^[6] These elements form an integrated pathway, often regulated to ensure efficiency and specificity within the constraints of cellular resources.^[2] Unlike static biological structures, which denote positional or compositional aspects, biological processes highlight temporal and functional dynamics.^[6]

Key Characteristics

Biological processes are fundamentally dynamic, unfolding over time through sequential series of molecular events that are often reversible and subject to intricate regulation. This time-dependent nature allows for adaptability, where processes can be modulated by environmental cues or internal signals to ensure organismal survival and function. For instance, regulatory mechanisms such as phosphorylation in signaling cascades enable rapid adjustments in process rates, preventing dysregulation that could lead to disease.^[7]^[6] A hallmark of biological processes is their emergent properties, arising from the collective interactions of individual molecular components to produce complex, higher-level outcomes not predictable from isolated parts alone. Simple interactions, such as binding events between proteins, can generate sophisticated behaviors like feedback loops in cellular signaling pathways, where positive or negative regulation amplifies or dampens signals to maintain homeostasis. These emergences highlight how processes at the molecular scale integrate to drive systemic responses, such as coordinated gene expression in response to stress.^[8]^[9] To identify a biological process, it must involve assemblies of biological entities—such as genes, proteins, or cells—occur in a context purposeful for the adaptation, maintenance, or environmental interaction of one or more organisms, and be empirically observable through experimental methods. This criterion distinguishes transient molecular events from structured processes essential to life cycles, requiring evidence from techniques like time-lapse imaging or biochemical assays to confirm their occurrence and regulation.^[6]^[9]^[10] Unlike purely physical or chemical processes, biological processes are uniquely tied to living systems through their evolutionary context, exhibiting high specificity shaped by natural selection to fulfill adaptive roles within organisms. While sharing chemical foundations, they incorporate genetic inheritance and regulatory networks that confer directionality and efficiency absent in abiotic reactions, enabling phenomena like self-replication and response to selective pressures.^[11]

Classification and Types

By Organizational Scale

Biological processes can be classified by the organizational scale at which they predominantly occur, reflecting the hierarchical structure of living systems from subatomic particles to ecosystems. This classification emphasizes the nested nature of biology, where processes at one level emerge from and influence those at adjacent levels, without fully reducing higher-level phenomena to lower ones.^[12] At the molecular scale, processes involve interactions among atoms, ions, and macromolecules, such as enzyme-substrate binding, where substrates bind to an enzyme's active site via noncovalent interactions to facilitate catalysis.^[13] Gene expression also operates at this scale, involving the transcription of DNA into RNA and its translation into proteins, regulated by molecular interactions that control genetic information flow.^[14] These processes form the foundational chemical reactions underlying all higher-level activities. The cellular scale encompasses processes within or between individual cells, integrating molecular components into functional units. Mitosis, for instance, is a eukaryotic cellular process that divides the nucleus into two identical sets of chromosomes, enabling cell replication and growth.^[15] Apoptosis represents another key cellular process, a programmed cell death mechanism that eliminates damaged or unnecessary cells through energy-dependent biochemical pathways.^[16] Such processes maintain cellular integrity and adaptability. At the organismal scale, processes coordinate across tissues, organs, and systems to sustain the whole multicellular entity. Homeostasis involves self-regulating mechanisms that maintain internal stability, such as temperature or pH balance, despite external fluctuations.^[17] The immune response exemplifies this scale, as a coordinated defense involving multiple cell types and organs to detect and neutralize pathogens throughout the body.^[18] Population and ecological scales address collective dynamics beyond single organisms. Gene flow at the population level refers to the transfer of genetic variants between populations via migration and reproduction, influencing genetic diversity and evolution.^[19] Nutrient cycling operates at the ecological scale, involving the movement and transformation of elements like nitrogen and phosphorus through biotic and abiotic components of ecosystems, supporting community productivity.^[20] Hierarchical integration links these scales, where lower-level processes provide building blocks for higher ones, giving rise to emergent properties not predictable solely from components below—for example, molecular reactions enable cellular division, which in turn supports organismal growth and population dynamics, while avoiding strict reductionism by recognizing scale-specific novelties.^[12]^[21]

By Functional Role

Biological processes can be categorized by their functional roles, which reflect their contributions to sustaining life, enabling adaptation, and facilitating interactions within and between organisms. This classification emphasizes the purpose-driven aspects of these processes, distinguishing them from categorizations based on scale or specific mechanisms. Key functional roles include metabolic, regulatory, reproductive and developmental, responsive, and those shaped by evolutionary pressures, each playing essential parts in organismal homeostasis and survival.^[22] Metabolic roles encompass processes that manage energy acquisition, transformation, and utilization, divided primarily into catabolism and anabolism. Catabolism involves the breakdown of complex molecules, such as carbohydrates and fats, into simpler units like glucose and fatty acids, releasing energy in the form of ATP to power cellular activities.^[23] In contrast, anabolism uses this energy to synthesize macromolecules, including proteins and nucleic acids, essential for growth and repair; for example, amino acids are assembled into proteins via ribosomal processes.^[23] These opposing yet interdependent pathways maintain metabolic balance, with dysregulation linked to conditions like diabetes, where impaired catabolism leads to energy deficits.^[24] Regulatory roles involve mechanisms that coordinate and fine-tune biological activities to ensure precise responses to internal and external cues. Signal transduction pathways, such as those mediated by G-protein-coupled receptors, transmit extracellular signals into intracellular events, often activating cascades like the MAPK pathway to modulate cell behavior.^[25] Gene regulation, meanwhile, controls the expression of genetic information through transcription factors that bind promoter regions, enhancing or repressing RNA synthesis; a seminal example is the lac operon in bacteria, where lactose presence induces operon activation for metabolism.^[25] These processes integrate environmental inputs with genomic outputs, preventing chaos in cellular function and enabling adaptability.^[26] Reproductive and developmental roles focus on processes that support organismal propagation, maturation, and trait inheritance across generations. Development entails orchestrated growth phases, such as embryogenesis, where cell differentiation and morphogenesis establish body plans via signaling gradients like Wnt pathways.^[27] Reproduction involves gamete formation (gametogenesis), fertilization, and embryonic implantation, ensuring genetic continuity; in mammals, this includes hormonal regulation by gonadotropins to synchronize ovulation and sperm maturation.^[27] Inheritance mechanisms, rooted in meiosis and DNA replication, transmit alleles faithfully, with epigenetic modifications adding layers of heritable variation without altering sequences.^[28] These roles underpin population persistence and biodiversity. Responsive roles enable organisms to adapt to environmental challenges through dynamic interactions and defenses. Stress responses, such as the heat shock pathway in eukaryotes, upregulate chaperone proteins to refold denatured molecules during thermal stress, preserving protein function and cell viability.^[29] Symbiosis represents mutualistic adaptations, where processes like nutrient exchange in mycorrhizal associations between fungi and plant roots enhance host resilience to drought by improving water uptake.^[30] These roles promote survival by buffering perturbations, with examples including coral-dinoflagellate symbioses that mitigate bleaching under elevated temperatures via photosynthetic energy provision.^[31] In an evolutionary context, functional roles of biological processes evolve through selection pressures, resulting in conserved mechanisms across species that reflect shared ancestry and adaptive utility. Core metabolic pathways, like glycolysis, are nearly universal from bacteria to humans, indicating ancient origins and retention due to their efficiency in energy extraction.^[32] Regulatory networks, such as Hox gene clusters directing body patterning, show homology in diverse taxa, evolving via gene duplication to accommodate morphological innovations while preserving foundational roles.^[32] Responsive processes, including innate immune signaling via Toll-like receptors, demonstrate conservation from insects to vertebrates, underscoring their role in pathogen defense across evolutionary lineages.^[33] This conservation highlights how functional roles balance innovation with reliability, driving diversification while maintaining essential life-sustaining functions.^[32]

Examples and Mechanisms

Molecular and Cellular Examples

One prominent example of a molecular biological process is DNA replication, which ensures the accurate duplication of genetic material during cell division. The process begins at origins of replication where helicase enzymes unwind the double-stranded DNA, creating a replication fork and exposing single-stranded templates.^[34] DNA polymerase then binds to these templates, synthesizing new complementary strands in the 5' to 3' direction; on the leading strand, synthesis is continuous, while on the lagging strand, it occurs in short Okazaki fragments primed by RNA primase.^[34] Proofreading is integral to fidelity, with the polymerase's 3' to 5' exonuclease activity detecting and excising mismatched nucleotides immediately after incorporation, reducing errors from an initial rate of about 10^{-5} to 10^{-7} per base pair.^[35] Overall replication fidelity, incorporating base selection, proofreading, and post-replicative mismatch repair, achieves an error rate of approximately $10^{-9} per base pair.^[36] Protein synthesis, or gene expression at the molecular level, encompasses transcription and translation to convert DNA into functional proteins. Transcription initiates when RNA polymerase II binds to promoter regions in eukaryotes, unwinding DNA and synthesizing messenger RNA (mRNA) complementary to the template strand in the 5' to 3' direction, with termination occurring at polyadenylation signals.^[37] The mRNA is then processed—capped, spliced, and polyadenylated—before export to the cytoplasm. Translation follows on ribosomes, large ribonucleoprotein complexes composed of small and large subunits that decode mRNA codons.^[38] Transfer RNA (tRNA) molecules, each carrying a specific amino acid and featuring an anticodon complementary to mRNA codons, deliver amino acids to the ribosome's peptidyl transferase center during elongation; the ribosome catalyzes peptide bond formation, translocating along the mRNA to build the polypeptide chain until a stop codon triggers release.^[39] Cell signaling at the cellular level often involves G-protein-coupled receptors (GPCRs), which transduce extracellular signals into intracellular responses, exemplified by the pathway leading to cyclic AMP (cAMP) production. Upon ligand binding to the GPCR's extracellular domain, the receptor undergoes a conformational change that activates an associated heterotrimeric G protein by exchanging GDP for GTP on the Gα subunit.^[40] The activated Gα-GTP dissociates and stimulates adenylyl cyclase, an enzyme that converts ATP to cAMP, the second messenger that amplifies the signal by activating protein kinase A and downstream cascades.^[41] This basic pathway—ligand binding → conformational change → G protein activation → second messenger production—regulates diverse cellular functions like metabolism and gene expression.^[40] Photosynthesis represents a fundamental cellular process in photoautotrophs, capturing light energy to fix carbon dioxide into organic compounds. The light-dependent reactions occur in thylakoid membranes, where chlorophyll in photosystems I and II absorbs photons, exciting electrons that drive an electron transport chain, generating a proton gradient for ATP synthesis via ATP synthase and reducing NADP⁺ to NADPH.^[42] These products then fuel the Calvin cycle in the stroma, a cyclic pathway divided into carbon fixation, reduction, and regeneration phases; ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) fixes CO₂ onto ribulose-1,5-bisphosphate to form 3-phosphoglycerate, which is reduced to glyceraldehyde-3-phosphate using ATP and NADPH, with some molecules exported to form glucose and the rest regenerating the CO₂ acceptor.^[43] The overall equation for the process is:

$6CO_2 + 6H_2O \xrightarrow{\text{light}} C_6H_{12}O_6 + 6O_2

This balanced reaction highlights the conversion of inorganic inputs into biomass, essential for cellular energy.^[42]

Organismal and Ecological Examples

At the organismal level, digestion represents a coordinated biological process that integrates mechanical, enzymatic, and transport mechanisms across the gastrointestinal tract to break down food and absorb nutrients. In mammals, enzymatic breakdown begins in the mouth with salivary amylase initiating starch hydrolysis, progresses in the stomach where pepsin and gastric acid degrade proteins, and intensifies in the small intestine via pancreatic enzymes like trypsin, lipase, and amylase that further cleave proteins, fats, and carbohydrates into monomers such as amino acids, fatty acids, and monosaccharides.^[44] Nutrient absorption then occurs primarily through the epithelial lining of the small intestine, where specialized structures like villi and microvilli increase surface area; transporters such as SGLT1 facilitate glucose and sodium uptake, while passive diffusion and facilitated transport via proteins like PEPT1 handle peptides and other molecules, ensuring efficient delivery to the bloodstream for organismal metabolism.^[44] The immune response exemplifies an organismal process that bridges innate and adaptive immunity, providing layered defense against pathogens through integrated signaling and effector functions. The innate phase activates rapidly via pattern recognition receptors on macrophages and dendritic cells, triggering phagocytosis and the release of cytokines like interleukin-1 (IL-1) and tumor necrosis factor (TNF) to amplify inflammation and recruit immune cells.^[45] This transitions to the adaptive phase, where antigen-presenting cells stimulate T and B lymphocytes; cytokine signaling, including IL-2 for T-cell proliferation and IL-4 for B-cell differentiation, coordinates the production of antibodies by plasma cells, which neutralize specific pathogens and facilitate their clearance, thereby conferring long-term immunity.^[45] On ecological scales, nutrient cycling sustains ecosystem productivity by recycling essential elements through microbial and organismal interactions, with the nitrogen cycle serving as a prime example of biogeochemical integration. Free-living and symbiotic bacteria, such as Rhizobium in legume root nodules, perform nitrogen fixation by converting atmospheric N₂ into ammonia (NH₃) via the enzyme nitrogenase, making it available for plant uptake.^[46] Ammonia is then oxidized to nitrite (NO₂⁻) and nitrate (NO₃⁻) through nitrification by soil bacteria like Nitrosomonas and Nitrobacter, allowing plants to assimilate nitrogen for growth; herbivores and decomposers return organic nitrogen to the soil, where denitrifying bacteria such as Pseudomonas reduce NO₃⁻ back to N₂ under anaerobic conditions, closing the cycle (N₂ → NH₃ → NO₃⁻ → N₂) and preventing nutrient accumulation or loss.^[46] Animal migration illustrates a behavioral biological process regulated hormonally at the organismal level while driving ecological dispersal and connectivity across habitats. In species like birds and salmon, photoperiod cues trigger hypothalamic release of gonadotropin-releasing hormone (GnRH), stimulating pituitary gonadotropins that elevate gonadal steroids such as testosterone and estrogen, which in turn promote fat deposition, hyperactivity, and orientation behaviors essential for long-distance travel. This hormonal orchestration not only synchronizes individual movements but also facilitates gene flow and resource redistribution in ecosystems, as migrating populations link distant food webs and influence predator-prey dynamics.^[47]

Study and Applications

Experimental Methods

Experimental methods in the study of biological processes encompass a range of laboratory techniques designed to observe, quantify, and perturb these processes at molecular, cellular, and organismal levels. These approaches enable researchers to gather empirical data on dynamic events such as protein interactions, gene expression changes, and metabolic fluxes, providing insights into underlying mechanisms. Key techniques include advanced imaging for real-time visualization, biochemical assays for reaction kinetics, genetic manipulation tools for causal inference, and high-throughput omics for comprehensive profiling.^[48] Microscopy and imaging techniques have revolutionized the observation of biological processes by allowing non-invasive, real-time tracking of molecular dynamics within living cells. Fluorescence microscopy, in particular, utilizes fluorescent tags attached to proteins or other biomolecules to visualize their localization, movement, and interactions with high spatial and temporal resolution. For instance, single-molecule fluorescence microscopy achieves a high signal-to-noise ratio, enabling the detection of individual protein molecules and their conformational changes during processes like enzyme catalysis or signal transduction. Confocal and total internal reflection fluorescence variants further enhance specificity by reducing background noise, facilitating studies of protein dynamics in vivo, such as membrane diffusion or cytoskeletal rearrangements. These methods have been instrumental in elucidating processes like cell migration, where fluorescently labeled actin filaments reveal polymerization rates in real time.^[49]^[50] Biochemical assays provide quantitative measurements of biological processes, particularly those involving enzymatic reactions and metabolite transformations. A foundational approach is the measurement of enzyme kinetics, which assesses how reaction rates vary with substrate concentration to infer catalytic efficiency and regulatory mechanisms. The Michaelis-Menten equation models this relationship, describing the initial velocity v of an enzyme-catalyzed reaction as dependent on the maximum velocity V_{\max}, substrate concentration [S], and the Michaelis constant K_m, which represents the substrate affinity:

v = \frac{V_{\max} [S]}{K_m + [S]}

This equation, derived from early 20th-century studies on invertase, allows researchers to determine kinetic parameters through spectrophotometric or fluorometric assays monitoring product formation over time. Such assays are widely applied to dissect processes like glycolysis, where hexokinase kinetics reveal regulatory points in glucose metabolism. Variations, including stopped-flow techniques, extend these measurements to fast reactions, ensuring accurate capture of transient intermediates in signaling cascades.^[51] Genetic tools enable precise manipulation of biological processes by altering DNA sequences, allowing causal relationships to be established through loss-of-function or gain-of-function experiments. The CRISPR-Cas9 system, adapted from bacterial adaptive immunity, uses a guide RNA to direct the Cas9 endonuclease to specific genomic loci for targeted cleavage, facilitating gene knockout or editing via non-homologous end joining or homology-directed repair. This method has transformed the study of processes like development and disease, as demonstrated in early applications where CRISPR-Cas9 disrupted genes involved in cell signaling pathways, revealing their roles in phenotypes such as immune response modulation. High-fidelity variants and delivery systems, including viral vectors, have improved specificity and efficiency, minimizing off-target effects in complex organisms. By introducing mutations or reporters, researchers can track process disruptions, such as altered transcription in response to environmental cues.^[52] Omics approaches offer high-throughput analysis of biological processes by generating genome-scale datasets on nucleic acids, proteins, and their modifications. Genomics techniques, such as whole-genome sequencing, identify genetic variations influencing processes like DNA replication or repair, providing a foundational map of process components. Proteomics employs mass spectrometry-based methods to quantify protein abundance, post-translational modifications, and interactions, enabling the dissection of dynamic networks in processes like apoptosis where caspase activation cascades are profiled. For transcription, RNA sequencing (RNA-seq) captures the transcriptome by converting RNA to cDNA and sequencing it deeply, quantifying expression levels to reveal regulatory dynamics, such as alternative splicing during neuronal differentiation. These integrated omics data, often analyzed via bioinformatics pipelines, uncover coordinated changes across process layers, as seen in studies linking genomic variants to proteomic shifts in metabolic disorders.^[48]^[53]^[54]

Modeling and Simulation

Modeling and simulation of biological processes involve the use of mathematical and computational frameworks to predict, analyze, and understand dynamic interactions within living systems, from molecular scales to ecosystems. These approaches enable researchers to test hypotheses, explore "what-if" scenarios, and integrate experimental data without the limitations of physical experimentation. By representing biological entities as variables and processes as equations or algorithms, models capture temporal evolution, spatial patterns, and emergent behaviors, often revealing insights inaccessible through observation alone.^[55] Deterministic models assume continuous and predictable changes, typically formulated as ordinary or partial differential equations that describe rates of change in biological quantities. A foundational example is the Lotka-Volterra equations for predator-prey dynamics, which model population oscillations in ecological systems. The equations are:

\frac{dN}{dt} = rN - aNP

\frac{dP}{dt} = eaNP - dP

where N is the prey population, P is the predator population, r is the prey growth rate, a is the predation rate, e is the efficiency of converting prey into predator biomass, and d is the predator death rate. These equations, independently derived by Alfred Lotka in 1925 and Vito Volterra in 1926, predict cyclic fluctuations driven by resource dependence and demonstrate stability around equilibrium points, influencing population ecology and resource management.^[56]^[57] Stochastic models incorporate randomness to account for variability in biological events, particularly useful for low-probability occurrences like molecular interactions. The Gillespie algorithm, also known as the stochastic simulation algorithm (SSA), provides an exact method for simulating chemically reacting systems by generating reaction events based on their propensity functions and waiting times drawn from exponential distributions. Introduced by Daniel T. Gillespie in 1977, it excels in modeling gene expression where rare transcription events lead to noise in protein levels, allowing precise quantification of fluctuations in cellular processes.^[58] In systems biology, network-based models integrate multiple processes across scales, such as metabolic pathways. Flux balance analysis (FBA) optimizes steady-state fluxes through genome-scale metabolic networks under constraints like nutrient uptake, assuming maximal biomass production as the objective function. Formulated as a linear programming problem, FBA predicts cellular phenotypes without kinetic details, as pioneered by Varma and Palsson in 1993 for Escherichia coli metabolism. This approach has reconstructed over 100 microbial networks, enabling predictions of growth rates and gene essentiality. These models find applications in predicting therapeutic interventions and long-term adaptations. Computational simulations of signaling pathways, using differential equations or agent-based methods, forecast drug impacts by perturbing network nodes, such as kinase inhibitors altering MAPK cascades in cancer cells, guiding personalized medicine.^[59] Similarly, evolutionary dynamics models, often via individual-based simulations, project adaptation trajectories, like antibiotic resistance emergence in bacterial populations under selection pressures.^[60]

References

[1]
Term Details for "biological_process" (GO:0008150) - AmiGO 2
A biological process is accomplished by a particular set of molecular ... Copyright © 1999-2025 the Gene Ontology · DOI Last file loaded on 2025-10-13 ...
[2]
Biological Pathways Fact Sheet
Aug 15, 2020 · A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
[3]
Body Functions & Life Process - SEER Training Modules
Basic life processes include organization, metabolism, responsiveness, movement, and reproduction. Humans also have growth, differentiation, respiration, ...
[4]
Understanding Biomolecular Processes: Toward Principles ... - NCBI
An essential feature of biology is the adaptability of living systems to their environment and to changing environmental pressures. Understanding the way living ...PROCESSES FAR FROM... · SELF-ASSEMBLY, DIRECTED...
[5]
biological_process Gene Ontology Term (GO:0008150)
A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific ...
[6]
The Gene Ontology and the meaning of biological function - PMC
In the GO, a biological process represents a specific objective that the organism is genetically “programmed” to achieve. Each biological process is often ...
[7]
Studying and modelling dynamic biological processes using time ...
Jul 18, 2012 · Biological processes are inherently dynamic and therefore capturing data about gene expression at multiple time points can provide valuable ...Key Points · Abstract · Main
[8]
https://www.nature.com/scitable/topicpage/biological-complexity-and-integrative-levels-of-organization-468
[9]
Mechanistic Explanation of Biological Processes
Jan 1, 2022 · Biological processes are often explained by identifying the underlying mechanisms that generate a phenomenon of interest.
[10]
Evolutionary biochemistry: revealing the historical and physical ...
Evolutionary biology accounts for the characteristics of living systems in terms of their histories; biochemistry explains those characteristics as the product ...<|control11|><|separator|>
[11]
Biological Complexity and Integrative Levels of Organization | Learn Science at Scitable
### Summary of Integrative Levels of Biological Organization
[12]
The Central Role of Enzymes as Biological Catalysts - The Cell - NCBI
Substrates initially bind to the active site by noncovalent interactions, including hydrogen bonds, ionic bonds, and hydrophobic interactions. Once a substrate ...
[13]
An Overview of Gene Control - Molecular Biology of the Cell - NCBI
Gene expression is controlled at multiple steps, with transcriptional control being most important. Different cells express different genes, and cells can ...
[14]
Genetics, Mitosis - StatPearls - NCBI Bookshelf - NIH
The mitotic phase is usually the shortest part of any cell cycle. · Throughout mitosis, certain checkpoints are essential to the continuation of the process.
[15]
Programmed Cell Death (Apoptosis) - Molecular Biology of the Cell
If cells are no longer needed, they commit suicide by activating an intracellular death program. This process is therefore called programmed cell death.
[16]
Homeostasis: The Underappreciated and Far Too Often Ignored ...
Homeostasis, as currently defined, is a self-regulating process by which biological systems maintain stability while adjusting to changing external conditions.Missing: organismal | Show results with:organismal
[17]
Physiology, Immune Response - StatPearls - NCBI Bookshelf - NIH
The immune response is a complex and highly coordinated process that the body uses to defend against pathogens such as bacteria, viruses, fungi, and parasites.Missing: organismal | Show results with:organismal
[18]
Natural Selection, Genetic Drift, and Gene Flow Do Not Act in ...
Gene flow is the movement of genes into or out of a population. Such movement may be due to migration of individual organisms that reproduce in their new ...
[19]
Nutrient Cycling - an overview | ScienceDirect Topics
Nutrient cycling, which describes the movement of elements through the biotic and abiotic environment, plays a central role in structuring ecosystems and food ...
[20]
Levels of Organization in Biology
Feb 5, 2018 · Typical levels of organization that one finds in the literature include the atomic, molecular, cellular, tissue, organ, organismal, group, ...
[21]
Regulation in Biological Systems - NCBI - NIH
Jun 9, 2023 · The regulatory system determines the interdependences between individual cells and the organism, subordinating the former to the latter.Missing: responsive evolutionary
[22]
Metabolism - PMC - PubMed Central
Figure 1. Anabolism utilises energy to make macromolecules and biomolecular polymers. Catabolism releases energy when these are broken down into simpler ...
[23]
Review Metabolism, homeostasis, and aging - ScienceDirect.com
Traditionally, metabolism is divided into catabolism and anabolism. Catabolism encompasses the processes of breaking down organic matter to obtain energy, and ...
[24]
Bridge between cell signaling and gene regulation - PubMed
In this review we focus on the role of TFs as a link between signaling pathways and gene regulation. Cell signaling tends to result in the modulation of a set ...
[25]
towards integration of signal transduction, regulation and ...
Mar 1, 2013 · Here, we review existing computational approaches that integrate signalling, gene regulation and/or metabolism.
[26]
The growing importance of genetics in human reproduction and ...
Human reproduction and growth depend on normal developmental processes such as the production of competent gametes, fertilization, embryonic development, ...Missing: inheritance | Show results with:inheritance
[27]
Reproduction in Complex Life Cycles: Toward a Developmental ...
Jan 1, 2022 · Inheritance is a process in which evolved mechanisms of development are propagated in reproduction. This concept is inclusive, admitting ...
[28]
Molecular mechanisms underlying stress response and adaptation
In this review, we summarize representative examples of organismal response and adaptation to various stresses. We also discuss the molecular mechanisms ...Missing: symbiosis | Show results with:symbiosis
[29]
Mycorrhizal Symbiosis in Plant Growth and Stress Adaptation
May 22, 2023 · Mycorrhizal Symbiosis in Plant Growth and Stress Adaptation: From Genes to Ecosystems. Annual Review of Plant Biology 74, 569 (2023); https ...
[30]
Symbiosis and stress: how plant microbiomes affect host evolution
Aug 10, 2020 · Many plant-associated microorganisms benefit the host via access to resources, protection from pathogens, or amelioration of abiotic stress.
[31]
Animal models and conserved processes
Sep 10, 2012 · The concept of conserved processes presents unique opportunities for using nonhuman animal models in biomedical research.
[32]
An evolutionary perspective on immunometabolism - Science
Jan 11, 2019 · Metabolism can be broadly divided into anabolic, energy-consuming, biosynthetic processes and energy-generating catabolic processes. Different ...Life History Theory As An... · The Hypothalamus As A... · Cellular Life History...Missing: responsive | Show results with:responsive<|control11|><|separator|>
[33]
DNA Replication Mechanisms - Molecular Biology of the Cell - NCBI
The first proofreading step is carried out by the DNA polymerase, and it occurs just before a new nucleotide is added to the growing chain. Our knowledge of ...
[34]
From DNA to RNA - Molecular Biology of the Cell - NCBI Bookshelf
Transcription and translation are the means by which cells read out, or express, the genetic instructions in their genes.
[35]
Ribosomes, Transcription, Translation | Learn Science at Scitable
(1) Translation begins when a ribosome (gray) docks on a start codon (red) of an mRNA molecule in the cytoplasm. (2) Next, tRNA molecules attached to amino ...
[36]
From RNA to Protein - Molecular Biology of the Cell - NCBI Bookshelf
The mRNA is then pulled through the ribosome; as its codons encounter the ribosome's active site, the mRNA nucleotide sequence is translated into an amino acid ...
[37]
GPCR | Learn Science at Scitable - Nature
Binding of an agonist to the seven-transmembrane G-protein-coupled receptor in the plasma membrane activates a pathway that involves G proteins as well as cAMP ...
[38]
Biochemistry, G Protein Coupled Receptors - StatPearls - NCBI - NIH
In mammalian cells, GPCR-induced cyclic AMP results in the activation of the cyclic AMP-dependent protein kinase (PKA). Once activated, PKA can phosphorylate ...Introduction · Fundamentals · Mechanism · Pathophysiology
[39]
Photosynthesis - The Cell - NCBI Bookshelf - NIH
Photosynthesis takes place in two distinct stages. In the light reactions, energy from sunlight drives the synthesis of ATP and NADPH, coupled to the formation ...Missing: equation | Show results with:equation
[40]
Chloroplasts and Photosynthesis - Molecular Biology of the Cell
This carbon-fixation cycle (also called the Calvin cycle) is outlined in Figure 14-39. It starts when 3 molecules of CO2 are fixed by ribulose bisphosphate ...
[41]
Physiology, Nutrient Absorption - StatPearls - NCBI Bookshelf
Oct 28, 2023 · The gastrointestinal tract is a highly specialized organ system primarily responsible for nutrient absorption, though it has other roles.
[42]
Overview of the Immune Response - PMC - PubMed Central
A major role of the T cell arm of the immune response is to identify and destroy infected cells. T cells can also recognize peptide fragments of antigens that ...Missing: organismal | Show results with:organismal
[43]
The Nitrogen Cycle: Processes, Players, and Human Impact - Nature
Denitrification is important in that it removes fixed nitrogen (i.e., nitrate) from the ecosystem and returns it to the atmosphere in a biologically inert form ...
[44]
The most common technologies and tools for functional genome ...
One of the biggest sources of biomedical and genomic information is the NCBI (National Center for Biotechnology Information), which provides access to other ...
[45]
Single-molecule fluorescence microscopy review - PubMed Central
Fluorescence microscopy is an indispensable tool in single-molecule investigations, providing a high signal-to-noise ratio for visualization while still ...Introduction · Fluorescence And Fluorescent... · Confocal Microscopy
[46]
Imaging molecular dynamics in vivo – from cell biology to animal ...
Sep 1, 2011 · Advances in fluorescence microscopy have enabled the study of membrane diffusion, cell adhesion and signal transduction at the molecular ...Confocal Laser Scanning... · Multiphoton Laser Scanning... · Photoactivation And...
[47]
Translation of the 1913 Michaelis-Menten Paper - PMC - NIH
In 1913 Leonor Michaelis and Maud Leonora Menten published their now classic paper, Die Kinetik der Invertinwerkung (1). They studied invertase, which was so ...
[48]
A Programmable Dual-RNA–Guided DNA Endonuclease ... - Science
Jun 28, 2012 · We propose an alternative methodology based on RNA-programmed Cas9 that could offer considerable potential for gene-targeting and genome-editing ...
[49]
High-throughput proteomics: a methodological mini-review - Nature
Aug 3, 2022 · In this review, we will discuss the advances in high-throughput proteomic techniques, statistics and algorithms, progress in applying proteomics to disease ...
[50]
RNA Sequencing and Analysis - PMC - PubMed Central - NIH
This article provides an introduction to RNA-Seq methods, including applications, experimental design, and technical challenges.
[51]
Perspectives on computational modeling of biological systems and ...
Jun 26, 2024 · In this perspective article, we briefly overview computational modeling in biology, highlighting recent advancements such as multi-scale modeling due to the ...Missing: paper | Show results with:paper
[52]
Alfred J. Lotka and the origins of theoretical population ecology - PMC
Aug 4, 2015 · In 1925 Vito Volterra, an eminent Italian mathematician, independently took up the analysis of predator–prey interactions, publishing a short ...
[53]
Lotka, Volterra and the predator–prey system (1920–1926)
In 1920 Alfred Lotka studied a predator–prey model and showed that the populations could oscillate permanently. He developed this study in his 1925 book ...
[54]
Exact stochastic simulation of coupled chemical reactions
Gillespie-Driven kinetic Monte Carlo Algorithms to Model Events for Bulk or Solution (Bio)Chemical Systems Containing Elemental and Distributed Species.
[55]
Computational modeling of drug response with applications to ...
Apr 1, 2022 · We review resources that hold information on molecular pathways that build the basis for constructing the model interaction maps, highlight ...
[56]
Computation and Simulation of Evolutionary Game Dynamics in ...
May 6, 2019 · The study of evolutionary dynamics increasingly relies on computational methods, as more and more cases outside the range of analytical ...