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Cyclopentolate

Cyclopentolate is a synthetic anticholinergic medication formulated as an ophthalmic solution, primarily used to induce mydriasis (pupil dilation) and cycloplegia (temporary paralysis of the ciliary muscle) for diagnostic eye examinations.^[1] As cyclopentolate hydrochloride, it has the molecular formula C₁₇H₂₅NO₃·HCl and acts by blocking muscarinic acetylcholine receptors in the iris and ciliary body, leading to relaxation of the sphincter muscle and inhibition of accommodation. First approved by the FDA in 1974,^[2] it is available in concentrations of 0.5%, 1%, and 2% and offers a faster onset (within 30 minutes) and shorter duration (up to 24 hours) compared to alternatives like atropine.^[3] In clinical practice, cyclopentolate is instilled as 1-2 drops into the eye, with effects peaking in 15-60 minutes and recovery typically occurring within 6-24 hours, though it may last longer in children or infants.^[1]^[3] Beyond routine refraction and fundus examinations, it aids in diagnosing refractive errors such as hyperopia and pseudomyopia, particularly in pediatric patients, and serves as an adjunct in treating anterior uveitis by preventing posterior synechiae and reducing ciliary spasm pain.^[4] Its cycloplegic effect is more potent than tropicamide, with residual accommodation of 0.5-1.75 diopters, making it suitable for accurate refraction in children where active accommodation can obscure results.^[4] Precautions are essential due to potential systemic absorption, especially in young children, where it may cause central nervous system effects like hallucinations, ataxia, or seizures; monitoring for 30 minutes post-administration is recommended, and feeding should be delayed for at least 4 hours in infants.^[1]^[3] Contraindications include hypersensitivity to the drug and narrow-angle glaucoma, as it can increase intraocular pressure.^[3] Common adverse reactions involve ocular irritation, blurred vision, photophobia, and stinging upon instillation, while rare systemic risks underscore the need for nasolacrimal duct compression to minimize absorption.^[4]^[3]

Medical Use

Indications

Cyclopentolate is primarily administered as ophthalmic eye drops to induce mydriasis, or pupil dilation, and cycloplegia, or temporary paralysis of the ciliary muscle, facilitating various diagnostic eye examinations.^[5] It is commonly employed for cycloplegic refraction to determine accurate refractive errors, as well as for ophthalmoscopy and retinoscopy to visualize the retina and assess visual function without interference from active accommodation.^[6] These effects enable precise evaluation of ocular structures and are particularly valuable in clinical settings where pupil constriction or focusing could obscure results.^[7] In pediatric ophthalmology, cyclopentolate holds specific benefits due to children's strong accommodative ability, which can mask underlying refractive errors during standard exams. By inducing cycloplegia, it ensures reliable refraction measurements, especially for detecting hyperopia or astigmatism in young patients, making it a standard agent for routine pediatric eye assessments.^[8] The duration of these effects varies: mydriasis typically persists up to 24 hours, while cycloplegia generally lasts 6 to 24 hours, allowing sufficient time for the procedure with gradual recovery of normal vision.^[9] Additionally, cyclopentolate is used as an adjunct in the treatment of anterior uveitis to prevent posterior synechiae formation and relieve pain from ciliary muscle spasm.^[10] Cyclopentolate is included on the World Health Organization's Model List of Essential Medicines, recognized in the 21st list published in 2019 and confirmed in the 22nd list of 2021, and remaining in the 24th list published in 2025, underscoring its importance as a cost-effective and essential tool for basic eye care in health systems worldwide.^[11]^[12] Off-label, cyclopentolate has been investigated for its potential as an antidote to counteract muscarinic and central nervous system effects of cholinomimetic agents, including in cases of organophosphate poisoning, though clinical applications remain limited and primarily supported by animal studies demonstrating protective effects when administered systemically.^[13]

Dosage and Administration

Cyclopentolate is available as an ophthalmic solution in concentrations of 0.5%, 1%, or 2%.^[14]^[15] For adults, the standard dose is one or two drops of 1% or 2% solution instilled into the conjunctival sac of the affected eye, which may be repeated after five to ten minutes if necessary for adequate mydriasis or cycloplegia.^[14]^[15] For refraction procedures, the drops are typically administered 40 to 50 minutes prior to the examination.^[5] In pediatric patients over one year of age, one or two drops of 1% solution are instilled into each eye, with a possible second application of 0.5% or 1% solution after five to ten minutes; for heavily pigmented irides, 2% may be used.^[14]^[16] For infants up to one year old, only one drop of 0.5% solution per eye is recommended, limited to a maximum of three doses at five- to ten-minute intervals, to minimize systemic absorption risks.^[16] In neonates and infants under six months, lower concentrations or alternative agents are preferred due to heightened susceptibility to systemic effects from increased absorption.^[15]^[5] To administer, patients should wash their hands thoroughly, tilt the head back, and gently pull down the lower eyelid to form a pocket in the conjunctival sac; the dropper tip should be held close to the eye without touching it or any other surface, and one drop squeezed into the pocket.^[1] After instillation, the eye should be closed gently, and finger pressure applied to the nasolacrimal sac for two to three minutes to reduce drainage and systemic exposure.^[1]^[15] Patients are advised to use sunglasses following administration due to induced photophobia, and contact lenses should be removed beforehand as the solution contains preservatives like benzalkonium chloride.^[1] Prior to use in patients suspected of glaucoma or with narrow angles, intraocular pressure should be measured to assess risk of elevation.^[15] Infants and young children require close observation for at least 30 minutes post-administration for signs of central nervous system or cardiopulmonary effects, with feeding withheld for four hours in infants to prevent aspiration.^[14]^[1] The mydriatic and cycloplegic effects typically last up to 24 hours, necessitating follow-up examinations within this period if further assessment is needed.^[15]^[14]

Adverse Effects

Ocular Effects

Cyclopentolate commonly causes transient stinging or burning sensation upon instillation, which typically resolves quickly after application.^[17] Blurred vision results from cycloplegia-induced loss of accommodation and is common, often persisting for several hours.^[18] Photophobia, due to mydriasis, lasts up to 24 hours in most cases and can be managed with UV-blocking sunglasses or tinted lenses.^[5] Mild conjunctival hyperemia, or redness, occurs in approximately 10.5% of pediatric patients receiving 1% cyclopentolate.^[19] Less common ocular effects include increased intraocular pressure, which carries a risk of angle-closure glaucoma in predisposed individuals.^[20] Punctate keratitis and eyelid edema have also been reported, though these are generally mild and self-limiting.^[17] In rare instances, synechiae may form due to prolonged pupil dilation.^[18] Management of these effects focuses on supportive measures; for example, nasolacrimal duct occlusion after instillation can minimize systemic absorption.^[17] If reversal is needed, miotics such as pilocarpine can be used to counteract cycloplegia and mydriasis, though efficacy varies.^[21] Cyclopentolate should be avoided in patients with narrow-angle glaucoma due to the risk of IOP elevation.^[1] Prolonged mydriasis beyond 24 hours occurs in some cases and may require protective eyewear or monitoring until resolution, which can extend to several days.^[9]

Systemic Effects

Systemic absorption of cyclopentolate, an anticholinergic agent, can lead to various non-ocular adverse effects, primarily due to its muscarinic receptor blockade. Common manifestations include dry mouth, tachycardia, facial flushing, thirst, and hyperthermia, which arise from reduced salivary secretion, increased heart rate, vasodilation, and impaired thermoregulation, respectively. These effects occur more frequently in children than adults, with incidence rates reported up to 10% following topical ophthalmic use, attributed to greater systemic absorption relative to body size.^[22]^[5]^[23] Neuropsychiatric effects are particularly concerning in vulnerable populations such as infants, the elderly, and individuals with dementia, where cyclopentolate can cross the blood-brain barrier and cause central nervous system disturbances. Reported symptoms include confusion, hallucinations, ataxia, and seizures, with pediatric cases documenting transient psychosis characterized by disorientation, visual disturbances, and incoherent speech. These reactions are more prevalent in young children due to immature metabolic pathways and higher relative drug exposure.^[24]^[25]^[26] In overdose scenarios, severe effects may include urinary retention, constipation from diminished gastrointestinal motility, and potentially coma, reflecting profound anticholinergic toxicity. Animal toxicity data indicate an oral LD50 of 4000 mg/kg in rats and 960 mg/kg in mice, underscoring the drug's relative safety at therapeutic doses but potential for harm with excessive exposure. Overdose management primarily involves supportive care, such as monitoring vital signs and ensuring hydration, with physostigmine administered as an antidote for life-threatening anticholinergic symptoms like severe delirium or respiratory compromise, as it reversibly inhibits acetylcholinesterase to counteract central effects.^[24]^[5]^[6]^[26] Risk factors for systemic effects include neonatal age, where absorption can be substantial due to lower body mass and blood volume leading to higher plasma concentrations; a history of epilepsy, which may exacerbate seizure risk; and concurrent use of other anticholinergic agents, potentiating toxicity. Most symptoms are self-limiting and resolve within 24-48 hours as the drug's short half-life allows for natural elimination.^[26]^[24]^[5]

Pharmacology

Mechanism of Action

Cyclopentolate functions as a non-selective competitive antagonist of muscarinic acetylcholine receptors (mAChRs), predominantly acting on those in the iris sphincter and ciliary muscle. This antagonism inhibits the binding of acetylcholine to these receptors, thereby blocking parasympathetic neurotransmission in the eye. The drug's stereoisomer (-)-cyclopentolate is primarily responsible for its pharmacological activity.^[17]^[27] By antagonizing receptors in the iris sphincter muscle, cyclopentolate prevents parasympathetic-mediated contraction, resulting in unopposed sympathetic dilation of the pupil and mydriasis. Similarly, blockade of receptors in the ciliary muscle inhibits its contraction, leading to relaxation of the suspensory ligaments and paralysis of accommodation (cycloplegia), which impairs the eye's ability to focus on near objects. The onset of mydriasis occurs within 15–30 minutes after topical administration.^[17]^[6]^[28] Compared to atropine, another muscarinic antagonist, cyclopentolate demonstrates lower binding affinity and faster dissociation from receptors, contributing to its shorter duration of action while achieving comparable cycloplegic effects. In experimental models, cyclopentolate has also shown potential as an antidote for organophosphate poisoning by competitively occupying muscarinic sites to reverse excessive cholinergic stimulation, as demonstrated in rodent studies using parenteral administration.^[17]^[13]

Pharmacokinetics

Cyclopentolate demonstrates rapid absorption following topical ocular administration, primarily through corneal penetration and nasolacrimal drainage, with additional contributions from transconjunctival routes. Systemic absorption is generally minimal but can lead to detectable plasma levels, reaching peak concentrations within 10 to 60 minutes after instillation.^[17]^[29] In children, particularly infants, systemic exposure is heightened relative to adults due to lower body weight and blood volume, resulting in plasma concentrations ranging from undetectable to 5.8 ng/mL after a 1 mg dose (one drop of 1% solution per eye).^[26]^[30] Nasolacrimal occlusion by applying pressure to the lacrimal sac for 2–3 minutes post-administration reduces systemic absorption by up to 60%, a practice especially recommended in pediatric patients to mitigate adverse effects.^[17]^[24] Following absorption, cyclopentolate distributes readily to ocular tissues, penetrating the aqueous humor where concentrations are approximately 3000 times higher than corresponding plasma levels, enabling its therapeutic action on muscarinic receptors in the iris and ciliary body. Systemic distribution occurs via the bloodstream, though the volume of distribution remains poorly characterized due to the predominance of the topical route and limited systemic exposure.^[31]^[6] Cyclopentolate undergoes metabolism primarily through hydrolysis by plasma pseudocholinesterase and hepatic esterases, yielding inactive metabolites through ester hydrolysis. This ester hydrolysis inactivates the drug, contributing to its relatively short systemic persistence.^[32]^[33] Excretion of cyclopentolate and its metabolites occurs mainly via the renal route. The plasma elimination half-life averages 100–111 minutes across formulations and populations, though mydriatic and cycloplegic effects may last 6–24 hours or longer due to sustained receptor occupancy.^[17]^[34]^[29]

Chemistry

Chemical Properties

Cyclopentolate is a synthetic anticholinergic agent with the chemical formula C₁₇H₂₅NO₃ for its free base form and a molar mass of 291.39 g/mol.^[2] The hydrochloride salt, commonly used in pharmaceuticals, has the formula C₁₇H₂₆ClNO₃ and a molar mass of 327.85 g/mol.^[35] Its IUPAC name is 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride.^[35] Cyclopentolate contains a chiral center at the 2-position of the acetic acid chain and is typically employed as a racemic mixture.^[2] The molecular structure features an ester linkage between 2-(dimethylamino)ethanol and 2-(1-hydroxycyclopentyl)-2-phenylacetic acid, resembling a tropic acid derivative but with a cyclopentyl ring replacing the tropane system found in natural anticholinergics.^[2] As a white to off-white crystalline powder, cyclopentolate hydrochloride exhibits good solubility in water (greater than 10 mg/mL) and alcohol, while being only slightly soluble in ether; a 1% aqueous solution typically has a pH of 4.5 to 5.5.^[36]^[35] The pKa for the tertiary amine group is approximately 8.0 (experimental value ~7.93), indicating basic character that facilitates protonation in acidic environments.^[37]^[35] Cyclopentolate hydrochloride is stable under acidic conditions but undergoes hydrolysis in alkaline solutions, following pseudo-first-order kinetics with degradation accelerating at higher pH levels, primarily yielding phenylacetic acid and other fragments.^[38] In pharmaceutical formulations, it is typically prepared as an ophthalmic solution with a pH range of 3.0 to 5.5 to optimize stability, corneal penetration, and compatibility with ocular tissues, often including preservatives like benzalkonium chloride.^[24] Regarding toxicity, the acute oral LD₅₀ in rats exceeds 4000 mg/kg, suggesting low acute systemic toxicity via this route, while no data indicate carcinogenic potential, and it is not classified as a carcinogen by major regulatory bodies.^[6]^[39]^[40]

Synthesis

Cyclopentolate was originally synthesized in 1951 through a multi-step process outlined in US Patent 2,554,511, developed by Gino R. Treves and assigned to Schieffelin & Co.^[41] The synthesis begins with the preparation of the key intermediate, 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid (also known as 1-hydroxycyclopentylphenylacetic acid), via a Grignard reaction for carbon-carbon bond formation. Sodium phenylacetate reacts with magnesium turnings and isopropyl bromide in anhydrous ether to generate the Grignard reagent, which is then added to cyclopentanone under reflux conditions. The adduct is hydrolyzed with dilute hydrochloric acid and extracted with sodium hydroxide solution, followed by acidification to isolate the intermediate acid in yields suitable for further processing.^[41] This carboxylic acid intermediate undergoes esterification to form the target compound. In the patented method, the acid is refluxed with β-chloroethyl dimethylamine in isopropyl alcohol for 16 hours, yielding the ester hydrochloride salt after filtration, solvent evaporation, and crystallization from ethyl acetate, with the product exhibiting a melting point of 134–136°C.^[41] Alternative routes, as described in pharmaceutical literature, involve reaction of the acid with 2-(dimethylamino)ethyl chloride in the presence of a base such as triethylamine to form the ester, followed by salt formation; this approach optimizes yields and simplifies purification in pharmaceutical production.^[42] Modern processes often use base-catalyzed addition of phenylacetic acid to cyclopentanone in aprotic solvents with organic bases to form the key intermediate, followed by esterification, achieving improved yields.^[43] Cyclopentolate was designed as a structural analogue of atropine, replacing the tropane ring with a cyclopentane moiety to achieve a faster onset of action (typically 30–45 minutes) and shorter duration while minimizing systemic toxicity compared to atropine, which has a higher incidence of side effects such as flushing and fever.^[6]^[44] The initial patent confirmed the structure using classical methods including elemental analysis and infrared spectroscopy, with later verifications employing nuclear magnetic resonance (NMR) spectroscopy to ensure purity in production batches.^[41]

History and Development

Discovery

Cyclopentolate was first synthesized in 1951 by G. R. Treves and F. C. Testa at Schieffelin & Co. as part of efforts to develop atropine-like anticholinergic agents with reduced duration of action and fewer systemic side effects. The compound, chemically known as 2-(dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetate hydrochloride, featured a cyclopentane ring in place of the tropane structure found in atropine and related alkaloids, aiming to maintain potent muscarinic antagonism while improving the therapeutic profile.^[17] The initial rationale focused on developing safer alternatives to atropine for systemic applications, particularly as antispasmodic agents for gastrointestinal disorders, where atropine's prolonged effects and toxicity limited utility. Preclinical testing began with in vitro and in vivo evaluations of anticholinergic potency, revealing strong inhibition of acetylcholine-induced contractions in isolated smooth muscle preparations. Early animal studies demonstrated cyclopentolate's potent mydriatic effects in rabbits and cats, with rapid onset of pupil dilation occurring within 5-15 minutes after topical ocular administration and recovery typically within 4-6 hours, contrasting with atropine's longer duration.^[45] These findings highlighted its superior profile compared to homatropine, another shorter-acting mydriatic, due to faster action and lower systemic absorption.^[45] The low toxicity observed in these models—minimal cardiovascular or respiratory effects even at high doses—prompted a shift in focus from gastrointestinal antispasmodic use to topical ophthalmic applications for diagnostic pupillary dilation and cycloplegia. The compound was first described in detail in a 1953 publication in the American Journal of Ophthalmology, which detailed its synthesis and preliminary pharmacological evaluation, establishing it as a promising anticholinergic for clinical exploration.^[46] This work underscored cyclopentolate's potential to address limitations of existing agents in ophthalmology, setting the stage for further targeted research.

Introduction to Clinical Use

Cyclopentolate transitioned from preclinical synthesis in 1951 to initial clinical evaluation in the early 1950s through ophthalmic studies focused on its cycloplegic and mydriatic properties for pediatric refraction, confirming safety and efficacy in dilating pupils and relaxing accommodation in children.^[17] These mid-1950s human trials emphasized its rapid onset and shorter duration compared to traditional agents, paving the way for regulatory approval. It was initially introduced to the market in 1953 by Schieffelin & Co., with the U.S. Food and Drug Administration granting approval in 1974 for Cyclogyl by Alcon, marking its formal recognition as a standard agent for eye examinations requiring cycloplegia.^[17]^[2] Pivotal clinical studies in the 1950s and 1960s demonstrated cyclopentolate's superior efficacy for cycloplegic refraction in pediatric populations, achieving adequate paralysis of accommodation with residual effects of 0.5-1.75 diopters, while exhibiting fewer systemic side effects than atropine, which often caused prolonged recovery times of 6-12 days.^[17] These trials, including comparisons in preschool children, highlighted cyclopentolate's faster recovery (6-24 hours) and reduced toxicity, leading to its widespread adoption in routine ophthalmic practice.^[47] Cyclopentolate was added to the World Health Organization's Model List of Essential Medicines in 2021 as a cycloplegic drug, and remains included as of the 24th list (September 2025).^[48] Regulatory milestones included approvals across Europe, such as in Spain in 1965 and broader marketing authorizations in the 1960s, facilitating global access.^[17] Warnings for pediatric risks, including behavioral disturbances and transient psychosis, were strengthened in product labels during the 1990s based on reported cases of central nervous system effects like hallucinations and agitation in young children.^[49] Dosage refinements in the 2000s stemmed from pharmacokinetic studies revealing systemic absorption and associated adverse effects, prompting recommendations to limit concentrations to 0.2-1% and instill 1-2 drops with nasolacrimal occlusion to minimize exposure, particularly in low-body-mass-index children where double dosing increased risks of tachycardia and CNS disturbances.^[17] These adjustments, informed by trials showing reduced weight gain and elevated plasma levels in neonates, optimized safety without compromising cycloplegic efficacy for refraction.^[50]

Society and Culture

Brand Names

Cyclopentolate is marketed under several brand names worldwide, primarily as an ophthalmic solution for inducing mydriasis and cycloplegia. The most prominent brand in the United States is Cyclogyl, produced by Alcon Laboratories, which is available in concentrations of 0.5%, 1%, and 2% as cyclopentolate hydrochloride.^[9] Other U.S. brands include AK-Pentolate (formerly by Akorn Pharmaceuticals, discontinued after 2023 manufacturer closure) and Pentolair, also in 1% concentration.^[51] In the United Kingdom, Mydrilate is a key brand, offered by Esteve Pharmaceuticals in 0.5% and 1% strengths for diagnostic eye examinations.^[52] Generic versions of cyclopentolate hydrochloride ophthalmic solution have been widely available since the expiration of key patents in the late 20th century, allowing multiple manufacturers to produce equivalents in standard concentrations of 0.5%, 1%, and 2%.^[6] Current generic producers include Sandoz and Bausch + Lomb, which supply 1% solutions in 15 mL bottles for clinical use.^[53] Cylate serves as a common generic equivalent, typically in 1% formulation.^[54] Some formulations combine cyclopentolate with phenylephrine to enhance mydriatic effects, such as Cyclomydril (0.2% cyclopentolate with 5% phenylephrine) by Alcon.^[6] Historically, Cyclogyl was developed and initially marketed by Schering-Plough before transitioning to Alcon Laboratories following corporate acquisitions.^[55] Regional variations exist, with brands like Cyclogyl (by Intas Pharmaceuticals) and Cyclomid (by Jawa Pharmaceuticals) available in India, often in 1% drops.^[56] No major brand discontinuations have been reported as of 2025, maintaining broad accessibility across markets.^[57]

Availability and Regulation

Cyclopentolate is available exclusively as a prescription medication worldwide and is not approved for over-the-counter use in any country.^[58]^[59] It is routinely stocked in hospitals, optometry clinics, and ophthalmology practices for diagnostic purposes, given its role in inducing mydriasis and cycloplegia.^[60] In the United States, the Food and Drug Administration (FDA) classifies cyclopentolate as pregnancy category C, indicating that animal reproduction studies have shown adverse effects on the fetus, but there are no adequate and well-controlled studies in humans, and it should be used during pregnancy only if the potential benefit justifies the potential risk.^[61]^[62] Cyclopentolate is not a controlled substance under the DEA schedules, as it is a non-narcotic anticholinergic agent.^[29] In the European Union, the European Medicines Agency (EMA) has approved cyclopentolate for diagnostic use in ophthalmology, with national authorizations ensuring its availability through regulated channels.^[63] In the United States as of 2025, a generic 1% ophthalmic solution of cyclopentolate typically costs between $3 and $15 per 2 mL bottle, depending on the pharmacy and discounts, making it an affordable option for routine clinical use.^[64]^[65] Prices are significantly lower in developing countries, often under $5 per bottle, facilitated by World Health Organization (WHO) essential medicines programs that promote access through bulk procurement and generic manufacturing.^[66] Supply shortages of cyclopentolate have occurred intermittently in the 2020s, primarily due to manufacturing disruptions, such as the closure of Akorn Pharmaceuticals in 2023 and raw material constraints during the COVID-19 pandemic, though alternative suppliers like Sandoz and Alcon have helped mitigate impacts.^[67]^[68] No major bans or widespread restrictions on its use exist globally.^[60] Internationally, cyclopentolate is recognized as an essential medicine by the WHO, included on the Model List of Essential Medicines since at least the 22nd edition in 2021 and retained in subsequent updates, ensuring its prioritization in over 100 countries for ophthalmic diagnostics. Export controls on cyclopentolate are minimal, as it is not classified as a dual-use substance under major international regimes, but its potential application as a mydriatic in chemical, biological, radiological, and nuclear (CBRN) incident management prompts monitoring in military and emergency contexts.^[69]

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The present invention relates to a preparation method of M-type choline receptor blocker cyclopentolate hydrochloride, comprising the following steps.Missing: Schering | Show results with:Schering
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Incidence of side effects of topical atropine sulfate ... - ResearchGate
Aug 8, 2025 · Conclusions: Atropine has a side effect incidence rate 7 times higher than the incidence rate of cyclopentolate. Flush and fever are the most ...<|control11|><|separator|>
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Cyclopentolate Hydrochloride: A New Mydriatic and Cycloplegic Agent
Cyclopentolate Hydrochloride: A New Mydriatic and Cycloplegic Agent: A Pharmacologic and Clinical Evaluation ... (1953), p. 110. (Jan.) View PDFView article ...
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(PDF) Cycloplegic Refraction in Children with Cyclopentolate versus ...
Aug 6, 2025 · Stolzar IH (1953) A new group of cycloplegic drugs. Am J Ophthalmol ... cyclopentolate 1 per cent and a combination of cyclopentolate 1per cent ...
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WHO Model List of Essential Medicines - Wikipedia
The first list was published in 1977 and included 208 medications. ... The WHO updates the list every two years. ... There are 306 medications in the 14th list in ...Therapeutic food · Prussian blue (medical use) · Pediatric counterpart · Isoflurane
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Cyclopentolate - Wikipedia
It is commonly used as an eye drop during pediatric eye examinations to dilate the eye (mydriatic) and prevent the eye from focusing/accommodating (cycloplegic) ...
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Neurotoxic Effects of Topical Cyclopentolate - PMC - PubMed Central
Cyclopentolate is a synthetic anticholinergic agent which produces mydriasis and cycloplegia. The advantages of this drug are rapid onset of action and recovery ...<|control11|><|separator|>
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Systemic Effects of Ophthalmic Cyclopentolate on Body Weight ... - NIH
Results indicate cyclopentolate is absorbed systemically and instillation of cyclopentolate decreases weight gain in neonatal mice compared to placebo.
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Cyclopentolate (Cyclogyl and others) - Uses, Side Effects, and More
Nov 11, 2024 · Cyclopentolate is commonly used to widen the pupils (dilation) and paralyze certain eye muscles to get your eyes ready for an eye exam or ...
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Mydrilate 1.0% Eye Drops - (emc) | 1724
Cyclopentolate is an anti-muscarinic agent used topically in the eye as a mydriatic and cycloplegic. The effects are similar to those of atropine, but with a ...
[50]
Cyclopentolate Ophthalmic Solution - Amcon Labs
Bausch + Lomb Cyclopentolate Hydrochloride Ophthalmic Solution 1% - 15mL · Sandoz Cyclopentolate Hydrochloride Ophthalmic Solution 1% - 15mL · Bausch + Lomb ...
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Cylate Uses, Side Effects & Warnings - Drugs.com
Nov 6, 2024 · Cyclopentolate relaxes muscles in your eye to dilate (widen) your pupil. Cylate (for the eyes) is used to dilate your pupil in preparation for an eye exam.
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CYCLOGYL- cyclopentolate hydrochloride solution/ drops - DailyMed
CYCLOGYL® (cyclopentolate hydrochloride ophthalmic solution, USP) is an anticholinergic prepared as a sterile, borate buffered, solution for topical ocular use.
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Cyclopentolate: Side Effects, Uses, Dosage, Interactions, Warnings
Contraindications. Hypersensitivity, untreated narrow angle glaucoma or increased intraocular pressure (IOP); untreated anatomically narrow angles; Sulfite ...
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Cyclogyl (Cyclopentolate Hydrochloride) - PharmaServe Canada
$$29.99 deliveryAvailability, Prescription-only. Common Side Effects. Like all medications, Cyclogyl (Cyclopentolate Hydrochloride) can cause side effects, although not ...Missing: worldwide | Show results with:worldwide<|separator|>
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Cyclopentolate 1% eye drops 0.5ml unit dose preservative free
Prescribing Status: Valid as a prescribable product. Controlled Drug Category: No Controlled Drug Status. Route: Ocular. Form: Eye drops. Ontology Form/Route ...
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Drug Shortages List - ASHP
Cyclopentolate and Phenylephrine Ophthalmic Solution, Oct 17, 2016, Oct 21, 2015. Cyclopentolate and Phenylephrine Ophthalmic Solution, Feb 11, 2022, Dec 14 ...Missing: worldwide | Show results with:worldwide
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Nov 6, 2024 · US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled ...
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Cyclopentolate Hydrochloride Ophthalmic Solution USP, 1% (Sterile)
Cyclopentolate Hydrochloride Ophthalmic Solution is used to produce mydriasis and cycloplegia in diagnostic procedures.
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cyclopentolate - Drug Central
FDA-approved. EMA-approved. PMDA-approved. Target Card Uniprot Example: P23975 ... Status: OFP. Legend: OFP - off patent. OFM - off market. ONP - on patent ...Missing: regulatory | Show results with:regulatory
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Cyclogyl Coupons & Prices - SingleCare
Cyclogyl costs around $45.67 for uninsured customers. With a SingleCare Cyclogyl coupon, you will pay $12.35 per 1, 2ml of 1% bottle for the same prescription ...
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WHO Model Lists of Essential Medicines
The WHO Model Lists of Essential Medicines are updated every two years by the Expert Committee on Selection and Use of Essential Medicines.Missing: cyclopentolate organophosphate 1980s
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Cyclopentolate Hydrochloride Ophthalmic Solution - ASHP
Reason for the Shortage · Akorn ceased operation in February 2023. · Sandoz has cyclopentolate ophthalmic solution available. · Alcon has Cyclogyl available.Missing: supply | Show results with:supply
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We urge providers to stay vigilant of fluctuations in drug availability and pricing in the near future and to remain closely in communication with patients who ...
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[PDF] NATO STANDARD AMedP-7.1 MEDICAL MANAGEMENT OF CBRN ...
Jun 1, 2018 · Is there a significant risk of international travel or trade restrictions? ... cycloplegic/ mydriatics (such as cyclopentolate, homatropine, ...