Fact-checked by Grok 2 weeks ago

Most recent common ancestor

The most recent common ancestor (MRCA) of a set of organisms, also known as the last common ancestor (LCA), is the most recent individual from which all members of that set are descended through their evolutionary lineages. This concept is central to , as it defines the point of for related taxa and underpins the of phylogenetic trees, where the MRCA is represented by the node at which lineages from the group converge. In , the MRCA helps quantify relatedness: taxa sharing a more recent MRCA are more closely related than those whose lineages split earlier. For example, on a of mammals, the MRCA of humans and chimpanzees is a hominid ancestor from approximately 6–7 million years ago, while the MRCA of all dates back further to around 60–80 million years. In , the models the time to the MRCA for lineages within a , often tracing back rapidly due to , with the expected time to coalescence for a sample of size n approximating 2N(1 - 1/n) generations in a Wright-Fisher model, where N is the . Notable examples illustrate the MRCA's application across scales. The matrilineal MRCA of all living humans, termed "," is estimated to have lived in between 100,000 and 200,000 years ago, based on variation. Similarly, the patrilineal MRCA, or "," dates to around 200,000–300,000 years ago. At the broadest level, the Last Universal Common Ancestor () is the MRCA of all cellular life on , hypothesized to have been a prokaryote-like organism existing approximately 4.2 billion years ago, with a complex cellular structure including membranes and metabolic pathways. These MRCAs do not imply a single founding population but rather the latest point where ancestry coalesces for the specified or group.

Definition and Concepts

Basic Definition

The most recent common ancestor (MRCA) of a set of , such as or , is defined as the latest from which all members of that set descend through an unbroken lineage of parent-offspring relationships. This concept applies broadly in to genes, populations, or taxa, where the MRCA represents the point of lineage coalescence most proximal to the present. In the framework of descent with modification, the MRCA embodies the shared heritage among descendants, marking the most recent juncture at which their evolutionary paths diverged while retaining common genetic or phenotypic traits derived from that ancestor. All descendants inherit elements from this ancestor, but earlier common ancestors exist further back in time, emphasizing that the MRCA is specifically the chronologically latest such shared forebear. To illustrate, consider a family tree: the MRCA of two first cousins is typically a shared , from whom both lineages descend directly without further branching , whereas a great-grandparent serves as a but is not the most recent one.

Distinction from Other Ancestors

The most recent common ancestor (MRCA) is frequently compared to the last common ancestor (LCA), with the two terms often employed interchangeably in phylogenetic analyses to denote the shared of a group of taxa. However, subtle distinctions arise in usage: the MRCA emphasizes the recency of the shared for a specific subset of lineages, marking the point of their most recent , whereas the LCA can specifically refer to the basal at the root of a or , encompassing all descendants from that divergence event. This differentiation helps clarify relationships within nested clades, where an MRCA for sister taxa may be more recent than the LCA of the broader group. The MRCA should not be confused with the "first" or original ancestor of a , as it does not represent the earliest evolutionary but rather the latest temporal point where descendant lineages unite before diverging. This conceptual focus on recency avoids implying a singular starting point for all , instead highlighting events in lineage histories. For instance, on a , the MRCA of two terminal taxa is the internal node closest to the present that connects them, distinct from deeper ancestral nodes that might qualify as earlier common ancestors. A prevalent misconception portrays the MRCA as invariably a single individual, yet in population-level contexts, it often comprises a contemporaneous group of individuals whose collective descendants include all members of the studied set. Mathematical models of ancestry demonstrate that, in expanding populations like that of modern humans, the MRCA can span multiple individuals within one or more generations, rather than pinpointing one person as the sole progenitor. This population-based view aligns with demographic realities, where ancestry coalesces through overlapping contributions rather than linear descent from a lone figure. In gene trees, the MRCA applies specifically to the coalescence of particular alleles or gene copies sampled from individuals, rather than the entire or species history, which can result in topologies that deviate from the species tree due to processes like incomplete sorting. For a given locus, the MRCA traces the most recent union of those allelic lineages, providing insights into localized evolutionary histories without assuming uniformity across the . This allele-specific nature underscores the modular structure of genetic , where different genomic regions may have distinct MRCAs.

MRCA in Phylogenetics

MRCA of Species

The most recent common ancestor (MRCA) of two or more is the last or individual from which their distinct evolutionary lineages diverged, represented as the internal node in a where the branches split. This node signifies the point of , after which the descendant lineages evolve independently, accumulating genetic and morphological differences that define separate . In , identifying the MRCA of species is fundamental to reconstructing the branching patterns of life's history, as it delineates the boundaries between monophyletic groups. A prominent example is the MRCA of humans (Homo sapiens) and chimpanzees (Pan troglodytes), estimated to have lived between 5 and 7 million years ago based on analyses and fossil correlations. Fossil evidence supporting this timeframe includes Sahelanthropus tchadensis, a 7-million-year-old hominid from whose cranial features—such as a small similar to chimpanzees and a more anteriorly positioned suggesting possible —indicate it may represent a form close to the human-chimpanzee split. This ancestor likely inhabited forested environments in , bridging ape-like and early human traits. The MRCA concept is essential for classifying clades, which are monophyletic assemblages comprising the MRCA and all its descendants, thereby organizing into hierarchical units like genera, families, and orders. By anchoring phylogenetic trees, MRCAs enable the dating of events through -calibrated molecular phylogenies, providing temporal frameworks for understanding adaptive radiations and patterns. For instance, the MRCA of all extant s is estimated at approximately 180 million years ago during the , derived from genomic reconstructions across diverse mammal orders that align with fossil records of early mammaliaforms.

MRCA within Populations

The most recent common ancestor (MRCA) within a refers to the most recent individual from whom all members of a defined group—such as a local , , or ethnic —descend through genetic . Unlike broader phylogenetic contexts, this focuses on intra-species dynamics, where the MRCA represents the point of coalescence for lineages within a single breeding or geographic unit, often influenced by localized evolutionary processes. A representative example is the MRCA of all modern Europeans, estimated to have lived approximately 1,000 years ago, due to extensive historical intermixing and across the , as inferred from genetic models of shared recent ancestry. This recency highlights how interconnected populations have become through centuries of and , forming the basis of contemporary . The recency of a population's MRCA is profoundly shaped by demographic factors. Larger effective population sizes (Ne) extend the expected time to MRCA (TMRCA), as the coalescence rate slows proportionally to 1/(2Ne), leading to older shared ancestors in stable, sizable groups; for instance, in models, the expected TMRCA for a sample of two individuals is 4Ne generations. Conversely, enhances between subgroups, effectively increasing Ne and delaying coalescence, which can push the MRCA further into the past by incorporating diverse lineages. Bottlenecks, however, drastically reduce Ne temporarily, accelerating coalescence and rendering the MRCA more recent, as lineages merge rapidly during periods of low numbers, such as during glacial maxima or plagues. In expanding populations, the MRCA often proves surprisingly recent due to founder effects, where small vanguard groups establish new territories, concentrating ancestry in a limited set of individuals whose lineages then radiate outward, minimizing deep coalescence through serial bottlenecks at expansion fronts. This dynamic is evident in models of human dispersal, where rapid growth from modest founding cohorts compresses genealogical timelines, contrasting with the deeper splits seen in isolated or contracting populations.

Genetic Lineages

Patrilineal MRCA

The patrilineal most recent common ancestor (MRCA), commonly known as , is the most recent individual male from whom all living males inherit their through direct paternal descent, representing the coalescence of all extant Y-chromosome lineages. This concept traces unbroken male-line inheritance, excluding females who do not carry a . Early genetic studies estimated Y-chromosomal Adam's lifespan at 60,000 to 140,000 years ago, based on initial Y-chromosome sequencing and phylogenetic modeling. Subsequent refinements, incorporating larger datasets and advanced sequencing, pushed this back; a 2023 analysis of 43 diverse Y chromosomes dated the TMRCA to approximately 183,000 years ago (95% highest posterior density interval: 160,000–209,000 years), with a 2025 study refining this to about 187,000 years ago (173,000–203,000 years) based on an ancestral-like Y reference sequence; evidence from deep-rooted African lineages confirms an origin in . The Y chromosome's largely non-recombining structure—spanning the male-specific region (MSY) of about 23 million s, with recombination limited to small pseudoautosomal boundaries—preserves paternal lineages intact across s, facilitating straightforward phylogenetic tracing. Single nucleotide polymorphisms (s) in this region accumulate steadily, with an estimated rate of roughly 3 × 10^{-8} per per (assuming ~30 years per ), enabling reliable dating of lineages through accumulated variants. In , this translates to an effective rate of about one phylogenetically informative every 100–150 years along the Y-chromosome tree. Importantly, was not the sole progenitor of modern humans; descent from him occurs only via the patrilineal line, and he coexisted with numerous other males whose lineages have since gone extinct. For context, this timeline now aligns more closely with that of the matrilineal MRCA (), estimated at 150,000–200,000 years ago, though the two ancestors were not contemporaries and represent separate uniparental inheritance paths.

Matrilineal MRCA

The matrilineal most recent common ancestor (MRCA), often referred to as , is the most recent woman from whom all living humans inherit their () through an unbroken maternal line. This uniparental inheritance pattern traces back to a single female ancestor in , whose mtDNA lineage coalesced due to the non-recombining nature of mtDNA, which is passed exclusively from mother to all offspring without contribution from the father. Unlike nuclear DNA, mtDNA evolves rapidly, with a approximately 5–10 times higher than nuclear DNA, accumulating about one substitution every 3,500–3,600 years across the entire 16,569-base-pair . This high makes mtDNA a valuable tool for studying uniparental inheritance and maternal lineages in human . Initial estimates placed Mitochondrial Eve's lifetime at approximately 200,000 years ago, based on mtDNA sequence variation from global populations. Subsequent refinements using for calibration have narrowed and adjusted this to around 150,000–200,000 years ago, with a 2013 study estimating 157,000 years ago (95% highest posterior density interval: 120,000–197,000 years) via sequences from 10 ancient modern humans spanning 40,000 years. Analyses up to 2023, incorporating larger datasets, continue to support a coalescence time of about 200,000 years ago, confirming her origin during the emergence of anatomically modern humans. These estimates derive from phylogenetic analyses of complete mtDNA genomes, calibrated against radiocarbon-dated ancient samples to account for purifying selection and varying substitution rates. Importantly, was not the only woman alive at her time, nor the first modern human; thousands of contemporaries existed, but all other maternal mtDNA lineages eventually went extinct through , leaving only hers in the present-day population. , the random fluctuation of allele frequencies in finite populations, favored the persistence of her lineage over millennia, particularly during population bottlenecks and expansions in . The timeline for the matrilineal MRCA overlaps potentially with that of the patrilineal MRCA (Y-chromosomal Adam), estimated at approximately 180,000–190,000 years ago (160,000–210,000 years), though the two ancestors were not contemporaries and represent separate uniparental histories.

Estimation Methods

Using Genetic Markers

Genetic markers such as single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), and whole-genome sequencing data are essential for tracing lineages and estimating the most recent common ancestor (MRCA) by identifying shared variations that indicate coalescence events in evolutionary history. SNPs, which are single base-pair changes, provide stable markers for deep-time ancestry due to their low mutation rates, allowing reconstruction of phylogenetic trees and haplogroup assignments that pinpoint MRCA points. In contrast, STRs, consisting of repeating DNA segments, mutate more rapidly and are particularly useful for resolving recent genealogical relationships within the last few hundred to thousand years. Whole-genome sequencing enhances resolution by capturing millions of SNPs across the genome, enabling finer detection of distant kinship and lineage divergence compared to targeted marker approaches. The process begins with sequencing DNA from relevant chromosomes, such as the Y-chromosome for patrilineal lines or (mtDNA) for matrilineal lines, followed by alignment to reference genomes to detect variants like SNPs that signal coalescence points where lineages merge. These variants are then compared across individuals to construct networks or phylogenetic trees, estimating the MRCA by counting shared mutations and applying mutation rate models. In , assignment exemplifies this: for instance, identifying specific SNPs on the Y-chromosome, such as those defining , groups individuals sharing a common patrilineal ancestor and refines MRCA dating through shared blocks. This method applies similarly to mtDNA like H, tracing maternal coalescence via non-recombining sequences. Key tools and databases facilitate marker analysis and lineage tracing. The provides a comprehensive catalog of , including data from diverse populations, supporting alignment and coalescence inference for global ancestry studies. For Y-chromosome analysis, FamilyTreeDNA's test sequences over 100 million base pairs to discover novel s, building a public haplotree that estimates patrilineal MRCAs through shared private variants. mtDNA databases like MitoSearch and PhyloTree enable haplotype matching for maternal lines by compiling global sequences, allowing users to identify shared mutations and potential MRCAs in non-recombining mtDNA. These resources integrate user-submitted data with reference panels for robust comparisons. Recent advances from 2023 to 2025 in ancient DNA (aDNA) integration have refined marker-based MRCA estimates by calibrating mutation rates and coalescence models with radiocarbon-dated genomes, improving accuracy for both modern and archaic human lineages. For example, aDNA from Neolithic and medieval samples has been used to validate SNP and mtDNA phylogenies, reducing uncertainties in TMRCA predictions by anchoring genetic clocks to fossil records. This calibration enhances the reliability of tools like whole-genome SNP analysis for tracing population-specific MRCAs.

Mathematical Models

Coalescent theory provides a foundational mathematical framework for modeling the time to the most recent common ancestor (TMRCA) by tracing lineages backward in time through a population's . In Kingman's coalescent model, introduced in , the process is approximated as a where pairs of lineages coalesce at a rate proportional to the inverse of the , assuming a large, randomly with no selection or . This model simplifies the complex of a sample of genes, focusing on the merging of ancestral lineages until they unite at the MRCA. For a sample of two genes in a diploid of constant effective size N_e, the expected TMRCA, denoted E[T_2], is $2N_e generations. The begins with the probability that two lineages coalesce in any given generation, which is approximately $1/(2N_e) under the Wright-Fisher model, as this represents the chance that they share a common . The waiting time to coalescence follows a with success probability $1/(2N_e), yielding an of $2N_e generations; more generally, for k lineages, the coalescence is \binom{k}{2}/(2N_e), and the expected time scales linearly with , emphasizing how larger populations lead to longer TMRCA due to reduced coalescence probabilities. Extensions to Kingman's basic model address real-world complexities, such as population structure. The structured coalescent incorporates spatial or demographic subdivision, where lineages in different coalesce within their group but between them, altering coalescence rates based on migration rates and deme sizes; for instance, formulation in models this as a multi-type coalescent process. Population bottlenecks, modeled as sudden reductions in N_e, accelerate coalescence by increasing the probability of lineage merging during the low-size period, thereby shortening the overall TMRCA compared to constant-size scenarios. These models predict that TMRCA is shorter in small or bottlenecked populations, where heightened coalescence rates compress genealogical depth, a pattern observed theoretically and applied to conservation genetics of with reduced effective sizes.

Time to MRCA Examples

TMRCA for All Living

The most recent common ancestor (TMRCA) of all living can be examined through both genetic and genealogical lenses. The genetic TMRCA refers to the point at which the lineages of specific genetic markers in all modern coalesce, while the genealogical TMRCA identifies the most recent individual from whom every living person descends through any combination of ancestral lines. These concepts highlight how ancestry converges more recently than might be expected given our ' age of approximately 300,000 years. For genetic markers, mitochondrial DNA (mtDNA), inherited solely from the mother, traces to a TMRCA known as , estimated at 155,000–160,000 years ago based on 2023 analyses of global mtDNA variation showing an origin. Similarly, the Y-chromosome, passed from father to son, points to a with a TMRCA around 200,000–300,000 years ago, derived from 2023 sequencing of diverse worldwide Y-chromosomes that reveal punctuated demographic expansions. In contrast, for autosomal DNA—the bulk of the nuclear genome inherited from both parents—coalescence times vary across loci due to recombination, typically ranging from 100,000 to over 1 million years ago. The genealogical TMRCA, representing the last individual ancestor of all humans regardless of genetic contribution, is estimated at 2,000–3,000 years ago according to computational models incorporating population substructure, , and growth rates. This surprisingly recent date arises from global interconnectivity: even isolated populations eventually share ancestors through intermarriage, compressing the backward in time. Recent demographic simulations continue to support these estimates without major revisions through 2025. Key factors influencing these TMRCA estimates include the Out-of-Africa migration event around 60,000–70,000 years ago, which created a severe that reduced outside and shaped subsequent patterns. Exponential population growth and widespread human migrations have further shortened the genealogical TMRCA by rapidly mixing lineages worldwide. Ancient DNA analyses from 2023 affirm an African origin for modern humans while revealing Eurasian back-migrations into starting around 5,000–3,000 years ago, introducing up to 40% non-African ancestry in some groups and underscoring the dynamic that influences both genetic and genealogical convergence.

Last Universal Common Ancestor

The () represents the most recent common ancestor of all extant life on , hypothesized as a prokaryotic from which the domains and diverged, while eukaryotes emerged later through endosymbiotic events. is not considered eukaryotic but rather a complex, single-celled microbe adapted to extreme conditions. A 2024 study using Bayesian molecular clock methods, calibrated against geological and isotopic evidence, estimates 's existence at approximately 4.2 billion years ago, with a 95% of 4.0–4.3 billion years ago. This timeline pushes closer to 's formation around 4.5 billion years ago than earlier models, which placed it at 3.5–3.8 billion years ago based on less refined phylogenetic dating and fossil correlations. The revision stems from improved handling of substitution rate variations and incorporation of Hadean-era environmental data. LUCA's reconstructed genome spanned roughly 2.6 million base pairs, encoding about 2,600 proteins dedicated to core processes like synthesis, , and energy metabolism via an Wood–Ljungdahl pathway. It inhabited a thermophilic, niche near deep-sea hydrothermal vents, relying on and as energy sources in a . Phylogenetic reconstruction identifies 399 conserved protein families as likely present in , supporting its autotrophic lifestyle and resistance to environmental stresses. Widespread horizontal gene transfer in early microbial communities further obscures LUCA's vertical inheritance, as genes could have been exchanged across lineages, necessitating rigorous tests to confirm ancestral origins over lateral acquisitions. Recent analyses from 2023 to 2025 reinforce these core genes while highlighting LUCA's role in an interconnected primordial ecosystem.

Advanced Topics

Identical Ancestors Point

The identical ancestors point (IAP), also known as the genetic isopoint, represents the most recent time depth in a population's history at which every individual from that era is either a genealogical ancestor of all living members of the population or an ancestor of none, due to the effects of pedigree collapse where ancestral lines increasingly overlap. This point lies beyond the most recent common ancestor (MRCA) and marks a transition where the collective pedigree of the present population converges to a universal set of forebears, with no partial contributions from individuals outside that set. The mathematical basis for the IAP arises in expanding populations, where the expected number of genealogical ancestors doubles each backward , leading to that quickly exceeds the historical size and forces overlaps through . Simulations accounting for factors such as , bottlenecks, and varying growth rates demonstrate that the IAP emerges when these overlapping s fill all ancestral slots, resulting in a outcome for past individuals: universal ancestry or complete in the present. For humans, the IAP is estimated to have occurred between approximately 5,300 and 2,200 BCE, based on computational models of global . Recent analyses incorporating identity-by-descent (IBD) tracking, which measures shared DNA segments inherited from common ancestors, have refined these estimates by simulating ancestry propagation in structured populations, confirming the IAP's position several thousand years ago while highlighting its sensitivity to historical migration patterns. This concept underscores the profound genealogical interconnectedness of all living humans, revealing that despite geographic and cultural separations, our shared ancestry converges rapidly in the relatively recent past, emphasizing the unity of the human .

Genealogical vs. Genetic MRCA

The genealogical most recent common ancestor (MRCA) refers to the most recent individual from whom an entire group of descendants is linked through all possible ancestral lines in a complete , representing a holistic connection across the full . This concept requires tracing every lineage without breaks, making it challenging to reconstruct empirically due to incomplete historical records, though mathematical models demonstrate that such an MRCA can exist relatively recently in large populations. In contrast, the genetic MRCA pertains to the most recent individual who contributed a specific or genetic segment to all members of the group at a particular locus, such as a (mtDNA) haplotype or a Y-chromosome marker. For uniparentally inherited markers like mtDNA, which do not undergo recombination, the genetic MRCA—often termed "" for humans—traces unbroken maternal lineages, providing a precise but partial view of ancestry limited to that single genetic pathway. Autosomal genetic MRCAs, however, are influenced by recombination, which shuffles genetic material during , resulting in fragmented inheritance where adjacent DNA segments may derive from different ancestors. The primary distinction lies in scope and traceability: the genealogical MRCA encompasses the entire and is holistic yet elusive without exhaustive records, whereas the genetic MRCA is locus-specific, offering high precision for targeted genes but capturing only a fraction of overall ancestry. Recombination further accentuates this gap for autosomal DNA, as it breaks into segments with independent coalescent histories, meaning a single can have multiple genetic MRCAs rather than a unified one. This fragmentation implies that while a genealogical MRCA may connect all descendants broadly, their genetic contribution dilutes over generations, potentially leaving no direct DNA traces in modern individuals despite the link. Recent ancient DNA studies have illuminated these dynamics through evidence of mosaic ancestry, where individual genomes exhibit patchwork contributions from diverse sources, underscoring multiple genetic MRCAs per in admixed populations. For instance, analyses of prehistoric East Asian samples reveal complex patterns, with autosomal regions sourcing from varied ancestral components, challenging simplistic single-MRCA models and highlighting how recombination integrates multiple lineages into contemporary genetic profiles. These findings update understandings of by demonstrating that genetic ancestry is not monolithic but segmented, with implications for interpreting events in evolutionary contexts.

References

  1. [1]
    Understanding evolutionary relationships
    that is, the youngest common ancestor that they all have in common. To find the most recent common ancestor ...
  2. [2]
    [PDF] RECENT COMMON ANCESTORS OF ALL PRESENT-DAY ...
    For example, “mitochondrial Eve” is the most recent common ancestor (MRCA) when ancestry is defined only through maternal lines.
  3. [3]
    Phylogenetic Trees and Geologic Time | Organismal Biology
    The root node represents the most recent common ancestor (MRCA) of all of the taxa represented on the tree. Time in this particular style of tree is represented ...
  4. [4]
    AV-237 - LUCA, Earth Life's Universal Common Ancestor
    Mar 8, 2025 · The primordial organism of most interest in the appearance of Earth life is called LUCA, the last universal common ancestor of contemporary life.
  5. [5]
    most recent common ancestor - Understanding Evolution
    (abbr: MRCA) The youngest common ancestor that two taxa share. On a phylogenetic tree, one can locate the most recent common ancestor of two terminal taxa ...Missing: biology | Show results with:biology
  6. [6]
    Recent Common Ancestor - an overview | ScienceDirect Topics
    The most recent common ancestor (MRCA) of all contemporary representatives of a particular DNA segment (e.g., the non-recombining portion of the Y chromosome) ...
  7. [7]
    Most recent common ancestor - ISOGG Wiki
    The most recent common ancestor (MRCA) of any set of individuals is the most recent individual from which all the people in the group are directly descended.Missing: biology | Show results with:biology
  8. [8]
    [PDF] Hennig ian Phylogenetics in Contemporary Systematics
    8.3, E is more closely. 1.c1atc.d to F than to D because E arid F share the more recent common ancestor c, while thc most recent common ancestor o f E ...
  9. [9]
    Understanding Evolutionary Trees | Evolution
    Feb 12, 2008 · ... most recent common ancestor of species A and B, and the one marked with two asterisks is the most recent common ancestor of species A, B, and C.Missing: terminology | Show results with:terminology<|control11|><|separator|>
  10. [10]
    Discordance of Species Trees with Their Most Likely Gene Trees
    Because of the stochastic way in which lineages sort during speciation, gene trees may differ in topology from each other and from species trees.Missing: whole | Show results with:whole<|control11|><|separator|>
  11. [11]
    Modern Humans Did Not Admix with Neanderthals during Their ...
    ... 45,000 y ago (Mellars 1992). This arrival coincided with the beginning of ... Since modern humans arrived in Europe approximately 40,000 y ago and ...
  12. [12]
    [PDF] Coalescent theory. - Columbia University
    The effects of variable population size are easiest to describe. Consider a population of current size N having relative size f (t) time t ago, where time is ...
  13. [13]
    Estimating time to the most recent common ancestor (TMRCA) - Nature
    Dec 16, 2015 · Estimating time to the most recent common ancestor (TMRCA): comparison and application of eight methods · Abstract · Introduction · Materials and ...<|control11|><|separator|>
  14. [14]
    Effects of recent population bottlenecks on reconstructing ... - PubMed
    ... (TMRCA) from MDIV were similar before and after bottlenecks; however, estimates of gene flow (M) were significantly lower in a few cases following a bottleneck.
  15. [15]
    The Geography of Recent Genetic Ancestry across Europe - PMC
    Most detectable recent common ancestors lived between 1,500 and 2,500 years ago, and only a small proportion of blocks longer than 2 cM are inherited from ...
  16. [16]
  17. [17]
    Mitochondrial DNA and human evolution - Nature
    ### Summary of Mitochondrial Eve and Related Concepts
  18. [18]
    An Improved Human Mitochondrial Molecular Clock - PubMed Central
    A new calibration for human mtDNA genomes has therefore been proposed, based on the rate of accumulation of synonymous mutations, thereby avoiding the selection ...
  19. [19]
    Mitochondrial DNA in Human Diversity and Health - PubMed Central
    Jul 27, 2023 · The present review explores the productive field of human mitochondrial genetics throughout 40 years of active research.2. The Mitochondrial Genome... · 3.3. Databases And Public... · 4. Mitochondrial Dna And...
  20. [20]
  21. [21]
    Improved Calibration of the Human Mitochondrial Clock Using ...
    The recent availability of ancient mitochondrial DNA sequences allows for a more direct calibration by assigning the age of the sequenced samples to the ...
  22. [22]
    African mitochondrial haplogroup L7 - Nature
    Jun 24, 2022 · Here we describe L7, an eighth haplogroup that we estimate to be ~ 100 thousand years old and which has been previously misclassified in the literature.Next-Generation Dna... · Results · Middle Stone Age Expansions...<|control11|><|separator|>
  23. [23]
    Next Generation Sequencing Plus (NGS+) with Y-chromosomal ...
    Sep 12, 2017 · ... SNPs than Y-STRs. Time estimates of the most recent common ancestor (MRCA) provided by Y-SNP haplogroup analysis are used to study ...
  24. [24]
    Interpreting short tandem repeat variations in humans using ... - NIH
    The SNP heterozygosity is a function of the time to the most recent common ancestor (TMRCA) of the haplotypes and the SNP mutation rate.
  25. [25]
    Determining Y-STR mutation rates in deep-routing genealogies
    Around 13,000 SNPs have been identified from whole genome sequencing data [3], while only a core set of Y-SNPs is needed for forensic or genealogical ...Research Paper · Introduction · Y-Str Mutation RatesMissing: primary | Show results with:primary
  26. [26]
    Forensic SNP genealogy inference using whole genome ...
    Compared to targeted sequencing, WGS can generate a higher density of SNPs, making it theoretically capable of analyzing more distant kinship relationships. For ...Missing: ancestor | Show results with:ancestor
  27. [27]
    Inference of Coalescence Times and Variant Ages Using ...
    Sep 20, 2023 · We developed a likelihood-free approach, called CoalNN, which uses a convolutional neural network to predict pairwise TMRCAs and allele ages from sequencing or ...Missing: haplogroup | Show results with:haplogroup
  28. [28]
    (PDF) Estimation of coalescence times from nucleotide sequence ...
    Aug 7, 2025 · This article proposes a method of estimating the time to the most recent common ancestor (TMRCA) of a sample of DNA sequences. The method is ...<|separator|>
  29. [29]
    mtDNA haplogroup and single nucleotide polymorphisms structure ...
    Apr 3, 2014 · Human populations can be divided into mtDNA haplogroups based on SNPs scattered throughout the mitochondrial genome, reflecting mutations ...
  30. [30]
    Benchmarking of human Y-chromosomal haplogroup classifiers with ...
    In this study, we present a benchmarking of five NRY haplogroup classification tools that could be easily upgraded to new versions of the ISOGG-Y-DNA tree. The ...
  31. [31]
    1000 Genomes | A Deep Catalog of Human Genetic Variation
    The 1000 Genomes Project created a catalogue of common human genetic variation, using openly consented samples from people who declared themselves to be healthy ...Data · About · Samples · Access HGSVC data
  32. [32]
  33. [33]
    Ancient mitogenomes from Neolithic, megalithic and medieval ...
    Oct 9, 2025 · In our current study, we have reconstructed for the first time the complete mitogenomes of Neolithic, megalithic and medieval individuals from ...
  34. [34]
    Estimating effective population size trajectories from time-series ...
    Jan 24, 2025 · Published ancient DNA (aDNA) data have surged in recent years. This growing dataset now enables researchers to track demographic changes and ...Missing: calibration | Show results with:calibration
  35. [35]
    The coalescent - ScienceDirect.com
    The n-coalescent is a continuous-time Markov chain on a finite set of states, which describes the family relationships among a sample of n members drawn ...Missing: paper | Show results with:paper
  36. [36]
    [PDF] Coalescent Theory - People @EECS
    Mar 24, 2000 · The coalescent process is a powerful modeling tool for population ge- netics. The allelic states of all homologous gene copies in a population.
  37. [37]
    Coalescent Theory: An Introduction - ResearchGate
    Aug 2, 2025 · The mathematical theory of genealogies has been mostly developed around the notion of coalescents, following the seminal work of Kingman (1982) ...
  38. [38]
    Inferring population size changes with sequence and SNP data
    Feb 20, 2013 · A bottleneck can drastically increase the rate of coalescence of lineages and cause severe deviations from the expectations of the standard ...
  39. [39]
    Demographic inference under the coalescent in a spatial continuum
    Under the so-called structured coalescent (Hudson, 1990, Notohara, 1990), the population is partitioned into demes, each deme corresponding to a geographic ...<|control11|><|separator|>
  40. [40]
    Punctuated bursts in human male demography inferred from 1244 ...
    We report the sequences of 1244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project.
  41. [41]
    Modelling the recent common ancestry of all living humans - PubMed
    These analyses suggest that the genealogies of all living humans overlap in remarkable ways in the recent past. In particular, the MRCA of all present-day ...Missing: misconceptions | Show results with:misconceptions
  42. [42]
    Evidence that two main bottleneck events shaped modern human ...
    Oct 7, 2009 · We find evidence of two primary events, one 'out of Africa' and one placed around the Bering Strait, where an ancient land bridge allowed passage into the ...Missing: 60000-70000 | Show results with:60000-70000
  43. [43]
    Eurasian back-migration into Northeast Africa was a complex and ...
    Nov 8, 2023 · They found that ancient East African hunter-gatherers form a cline of ancestry with modern-day southern African hunter-gatherer (San) groups.Missing: 2023-2025 | Show results with:2023-2025
  44. [44]
    The nature of the last universal common ancestor and its impact on ...
    Jul 12, 2024 · Age estimates for LUCA are usually based on the fossil record, varying with every reinterpretation. The nature of LUCA's metabolism has proven ...
  45. [45]
  46. [46]
    Number of ancestors and length of identity-by-descent tracks over time
    Aug 29, 2024 · This study focuses on small, insular populations, where the number of genetic ancestors can swiftly encompass the entirety of genealogical ...Missing: point | Show results with:point
  47. [47]
    [PDF] to what extent does genealogical ancestry imply genetic ancestry?
    Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past [4, 15].
  48. [48]
    Genetic evidence and the modern human origins debate | Heredity
    Mar 5, 2008 · ... most recent common ancestor of humanity for a given haplotype and ... last common ancestor of modern humans and Neandertals. They found ...Missing: terminology | Show results with:terminology
  49. [49]
    A general and efficient representation of ancestral recombination ...
    Nov 4, 2023 · As a result of recombination, adjacent nucleotides can have different paths of genetic inheritance and therefore the genealogical trees for ...
  50. [50]
    The complex genetic landscape of southwestern Chinese ... - Frontiers
    Other six ancestral components contributed to the mosaic ancestry composition of modern and ancient East Asians and their geographical neighbors (Figure 1B).<|control11|><|separator|>