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Premotor cortex

The premotor cortex (PMC) is a critical region of the frontal lobe in the cerebral cortex, situated immediately anterior to the primary motor cortex (M1) within Brodmann area 6, and it plays a central role in the planning, selection, and coordination of voluntary movements by integrating sensory, cognitive, and motivational inputs to guide motor output.^[1] It encompasses both lateral and medial components, with over 30% of the corticospinal tract axons originating from its neurons, enabling direct influence on spinal motor circuits.^[1] Anatomically, the PMC is characterized by agranular or dysgranular cortical architecture, lacking a prominent granular layer IV, and it extends across the precentral gyrus, precentral sulcus, caudal superior frontal sulcus, and middle frontal gyrus.^[2] Recent cytoarchitectonic studies have refined its mapping into seven distinct areas—dorsal (6d1–3), ventral (6v1–3), and rostral (6r1)—based on histological analyses of human post-mortem brains, highlighting its rostral border extending further than previously thought into the middle frontal gyrus.^[3] The PMC is subdivided into several functional and anatomical regions, including the dorsal premotor area (PMd, areas F2 and F7), ventral premotor area (PMv, areas F4 and F5), supplementary motor area (SMA, area F3), pre-SMA (area F6), and cingulate motor areas (e.g., 24c, 6c, 23c), each contributing to specific aspects of motor control.^[2] The lateral PMC, particularly PMd and PMv, processes external cues such as visual or auditory stimuli to select and prepare movements, with neurons activating prior to movement onset in response to environmental triggers.^[1] In contrast, the medial PMC, including SMA and pre-SMA, handles internally generated or self-initiated actions, showing activity 1–2 seconds before voluntary movements without external prompts, and is involved in sequencing complex motor tasks like those requiring memory guidance.^[1] Lesion studies in primates demonstrate that damage to the lateral PMC impairs performance in visually guided tasks, while medial lesions reduce spontaneous movement initiation, underscoring their complementary roles.^[1] Functionally, the PMC integrates multisensory information with cognitive processes to facilitate goal-directed actions, including reaching, grasping, and oculomotor control, and in non-human primates, the PMv (particularly area F5) contains mirror neurons that activate both during action execution and observation, supporting action understanding and imitation, although the precise role and existence of such neurons in humans remain subjects of debate and ongoing research; homologous regions in humans show similar activity via neuroimaging.^[2] The PMd is specialized for rule-based movement selection and spatial prediction, such as in leg or arm reaching, while the PMv focuses on object-oriented actions like grasping and mouth movements, with the frontal eye fields (FEF) localized within ventral areas 6v1–2 for gaze control.^[3] Connectivity-wise, the PMC receives afferents from parietal association areas, dorsolateral and ventrolateral prefrontal cortex, and the thalamus, allowing sensorimotor integration, and projects efferents to M1, the spinal cord, and brainstem via corticospinal and corticobulbar tracts to execute planned movements.^[2] Beyond motor functions, emerging evidence links the PMC to cognitive domains like working memory, task switching, and motivation, with the pre-SMA implicated in response inhibition and general motor learning.^[4] Human imaging studies, including fMRI and PET, consistently activate PMC regions during motor preparation and execution, confirming its pivotal role in bridging intention and action.^[5]

Anatomy

Location and Boundaries

The premotor cortex is located in the frontal lobe of the cerebral cortex, immediately anterior to the primary motor cortex, which corresponds to Brodmann area 4. It primarily encompasses Brodmann area 6, a region traditionally divided into lateral premotor areas on the convexity and medial supplementary motor areas. This positioning places it on the lateral and medial surfaces of the frontal lobe, contributing to the higher motor regions involved in voluntary movement organization. The premotor cortex is bounded posteriorly by the central sulcus, which separates it from the primary motor cortex and the parietal lobe. Anteriorly, it is delimited by the precentral sulcus, with its rostral extent varying individually but generally reaching into the caudal portions of the superior and middle frontal gyri. Medially, it lies adjacent to the supplementary motor area on the medial wall, while ventrally it borders the frontal operculum near the lateral fissure; these boundaries have been confirmed as observer-independent through cytoarchitectonic analysis of post-mortem human brains using statistical methods like the Grey Level Index and Mahalanobis distance. In the 2025 revised mapping, the premotor cortex occupies the precentral gyrus, precentral sulcus, caudal superior frontal sulcus, and parts of the superior and middle frontal gyri, with coordinates in MNI space extending to y=15-17 mm rostrally.^[3] Cytoarchitectonically, the premotor cortex is characterized by agranular frontal cortex with fewer or absent Betz cells compared to the primary motor cortex, where these giant pyramidal neurons are prominent in layer V. Layer IV is less developed or rudimentary in the premotor cortex, contributing to its overall weaker laminar differentiation, though ventral subregions show transitional dysgranular features with thin layer IV. The 2025 study identified seven distinct areas within the human premotor cortex—dorsal areas 6d1-3 (agranular with denser layer II) and ventral areas 6v1-3 plus 6r1 (more columnar with higher layer IIIc density)—refining boundaries beyond classical Brodmann maps.^[3] In comparison to non-human primates, the human premotor cortex retains a homologous organization into dorsal (PMd) and ventral (PMv) divisions, but exhibits greater subdivision and microstructural complexity, as evidenced by the identification of additional areas in recent human-specific mappings. This expanded parcellation in humans aligns with evolutionary differences in frontal lobe expansion, though core borders like the central sulcus remain conserved across primates.

Subdivisions

The premotor cortex is primarily divided into a dorsal premotor cortex (PMd) and a ventral premotor cortex (PMv), a subdivision supported by both structural and functional distinctions observed in primates and extended to humans.^[3]^[2] Within the PMd, further compartmentalization includes a caudal portion (PMDc, corresponding to area F2) and a rostral portion (PMDr, area F7); similarly, the PMv consists of a caudal portion (PMVc, area F4) and a rostral portion (PMVr, area F5).^[2]^[6] These delineations originate from cytoarchitectonic and connectional studies in macaques but are applied analogously in human brain mapping.^[7] Cytoarchitectonically, the PMd exhibits an agranular structure with minimal granule cells and a poorly defined layer IV, while the PMv displays a more dysgranular organization featuring a thin but discernible layer IV with denser granule cells.^[2]^[6] Recent human-specific mappings from 2025 refine these features through quantitative analysis of cortical layer thickness and cell density, revealing subtle variations such as higher cell density in columnar arrangements within ventral areas and denser pyramidal cells in specific sublayers of dorsal regions.^[3] In humans, volumetric assessments indicate the total premotor regions span approximately 35–40 cm³ across both hemispheres, with individual subareas having mean volumes of 4,300–6,200 mm³ per hemisphere and no significant hemispheric or gender differences (as of the 2025 study).^[3]

Functions

Motor Planning and Preparation

The premotor cortex plays a crucial role in generating neural signals that coordinate complex, multi-joint movements, distinguishing it from the primary motor cortex, which primarily drives discrete activation of individual muscles for execution. In primate studies, microstimulation of premotor areas evokes coordinated actions such as reaching toward objects in peripheral space or adjusting grip postures, integrating multiple limb segments into purposeful sequences.^[8] This higher-level organization allows the premotor cortex to assemble motor programs that account for biomechanical constraints across joints, facilitating smooth transitions in tasks like grasping or pointing.^[9] The region is particularly engaged in abstract rule-based tasks, including conditional motor responses as seen in go/no-go paradigms, where decisions to initiate or withhold actions depend on learned associations rather than direct sensory triggers. In macaque monkeys performing such tasks, premotor neurons initially respond similarly to instructional cues in both go and no-go conditions but diverge around 250 ms after cue onset, with sustained activity in go trials reflecting the selection and commitment to a response.^[10] This differential firing supports the internal representation of rules, enabling flexible adaptation to contextual demands without immediate movement. Premotor neurons exhibit tonic firing patterns during the preparatory phase of movements, sustaining elevated activity to integrate internal goals such as postural adjustments prior to reaching or manipulating objects. This sustained discharge, observed in delay periods of cue-based tasks, correlates with movement speed and readiness.[^1] For instance, in visually guided arm tasks, these neurons maintain activity levels that predict the efficiency of subsequent actions, bridging cognitive intent with motor output.[^1] Supporting evidence from primate electrophysiology demonstrates that dorsal premotor (PMd) neurons activate hundreds of milliseconds before movement onset in cue-based reaching tasks, encoding directional and extent information during the preparatory interval. In these studies with macaques, single-unit recordings reveal task-related modulation in 75% of premotor neurons during the post-cue delay, prior to any overt arm or eye movement, underscoring the area's anticipatory function.^[9] Human neuroimaging studies, such as fMRI, confirm similar preparatory activity in the premotor cortex during motor planning tasks.[^2]

Sensory Integration and Guidance

The premotor cortex plays a crucial role in integrating multiple sensory modalities, including visual, proprioceptive, and vestibular inputs, to guide externally directed movements such as reaching toward objects in the environment. Neurons in this region receive substantial projections from parietal sensory areas, enabling the transformation of visuospatial information into motor commands for precise action execution. For instance, visual cues about object location are combined with proprioceptive feedback on limb position and vestibular signals related to body orientation, allowing adaptive adjustments during tasks like grasping or pointing. This multisensory convergence supports the spatial and temporal coordination required for goal-oriented behaviors, with the premotor cortex acting as a hub for sensorimotor transformations that ensure movements align with external stimuli.^[11]^[2]^[12] The ventral premotor cortex (PMv), particularly area F4, is specialized in representing peripersonal space—the region immediately surrounding the body—through the integration of tactile, visual, and proprioceptive inputs. Neurons here exhibit bimodal receptive fields that respond to stimuli near specific body parts, such as the face or arms, with visual responses triggered by objects approaching within this space and aligned with somatosensory fields. This representation facilitates defensive actions or object interactions by encoding the spatial relationship between the body and nearby stimuli, independent of eye position in most cases, thereby supporting hand- or body-centered guidance of movements. Electrical stimulation of PMv elicits complex, spatially organized defensive-like responses, underscoring its role in multisensory control of peripersonal interactions.^[13]^[14] In contrast, the dorsal premotor cortex (PMd) contributes to predictive coding of limb trajectories by incorporating sensory predictions about upcoming movements, particularly in visually guided reaching. Neural populations in PMd encode conditional probability distributions of reach directions based on current hand position within the workspace, allowing the brain to anticipate and bias trajectories toward likely targets before they are fully specified. This predictive mechanism refines movement planning by narrowing the range of possible paths as sensory constraints (e.g., limb posture) limit options, enhancing efficiency in dynamic environments. Such coding is evident in tasks where PMd activity peaks for expected directions, influencing both latency and path curvature.^[15]^[16] A key feature of the rostral portion of the ventral premotor cortex (PMVr, or area F5) involves mirror neurons, which fire during both the observation and execution of goal-directed actions like grasping. Discovered in macaque monkeys in 1992, these neurons respond to the sight of transitive movements (e.g., grasping an object) in a congruent manner to the monkey's own actions, facilitating an internal simulation of observed behaviors. This mechanism supports sensory guidance by linking visual input of others' actions to one's own motor repertoire, aiding in action understanding and imitation without direct sensory feedback from execution.^[17] Lesion studies provide behavioral evidence for the premotor cortex's role in sensory-guided movements, revealing selective deficits in visually guided reaching while sparing internally generated actions. In monkeys with unilateral premotor ablations, contralateral reaching around obstacles to visible targets is impaired, with animals tending to move directly toward the target's apparent location rather than accounting for barriers, indicating disrupted integration of visual spatial cues. Human patients with premotor lesions similarly show slowed trajectory corrections during visually guided grasps, though endpoint accuracy remains intact, highlighting the region's necessity for online sensory-motor adjustments in external contexts.^[18]^[19]^[20]

Neural Connections

Afferent Inputs

The premotor cortex (PMC) receives a diverse array of afferent inputs from cortical and subcortical structures, which provide essential sensory, spatial, cognitive, and modulatory signals for motor planning. These inputs are organized in a segregated manner, particularly between the dorsal premotor cortex (PMd) and ventral premotor cortex (PMv), reflecting their specialized roles in externally guided versus object-oriented movements. Corticocortical projections form the majority of direct inputs, while subcortical pathways relay through the thalamus to integrate feedback for timing and correction. Major cortical afferents originate from the posterior parietal cortex, conveying spatial and sensory information critical for visuomotor transformation. The PMd receives prominent inputs from dorsal parietal areas, such as the superior parietal lobule (including areas 5 and the medial intraparietal area, MIP), which supply representations of limb position and reach-related spatial coordinates. In contrast, the PMv is targeted by ventral parietal regions, including area 7a and the ventral intraparietal area (VIP), providing multisensory signals about object location, visual space, and head-centered coordinates for grasping and manipulation tasks. These pathways exhibit largely segregated connectivity, with dorsal parietal inputs favoring PMd for predictive spatial guidance and ventral inputs supporting PMv's role in interactive behaviors.^[21] Projections from the prefrontal cortex further modulate PMC activity based on cognitive demands. The dorsolateral prefrontal cortex (DLPFC, areas 9 and 46) sends inputs primarily to the PMd, facilitating executive control, rule-based selection, and integration of abstract goals into motor sequences. Meanwhile, the ventrolateral prefrontal cortex (VLPFC, areas 45 and 12) projects densely to the PMv, supporting object-specific manipulation through associations between sensory cues and affordances. These prefrontal afferents enable contextual adaptation of movements, with direct corticocortical fibers emphasizing top-down regulation over sensory-driven responses.^[22] Somatosensory inputs to the PMC arise from primary and higher-order areas, emphasizing proprioceptive and tactile feedback for body schema maintenance. Area 3a, a proprioceptive subregion of the primary somatosensory cortex, provides inputs related to muscle and joint position, particularly for proximal limbs and trunk movements. The secondary somatosensory cortex (SII) contributes additional tactile and multimodal signals, reinforcing representations of body posture and contact forces in both PMd and PMv. These connections are denser for axial and girdle musculature, aiding in the coordination of posture and limb orientation.^[23] Subcortical afferents reach the PMC indirectly via thalamocortical relays, integrating basal ganglia and cerebellar outputs for refined motor control. The basal ganglia, through the ventral anterior (VA) and ventrolateral (VL) thalamic nuclei, project to the PMC to convey signals for motor initiation timing and suppression of unwanted actions, with pallidal inputs modulating vigor and sequence selection. Cerebellar efferents, relayed via the VL thalamus (particularly VLp subnucleus), supply predictive error signals for trajectory adjustments and coordination, enhancing accuracy in ongoing movements. These pathways ensure temporal precision and adaptive correction without direct cortical involvement.^[24]^[25]

Efferent Outputs

The premotor cortex (PMC) exhibits strong efferent projections to the primary motor cortex (M1, area 4), which are essential for the initiation and execution of voluntary movements. These connections are topographically organized, with the dorsal premotor cortex (PMd) primarily targeting the arm and shoulder representations in M1 to facilitate proximal limb control, while the ventral premotor cortex (PMv) projects more densely to the hand and digit regions, supporting fine motor adjustments. Such projections arise predominantly from layer V pyramidal neurons and contribute to modulating M1 output through both excitatory and inhibitory influences, as demonstrated in tracer studies in nonhuman primates.^[26]^[27] In addition to cortical targets, the PMC sends direct and indirect efferents to the spinal cord, influencing axial and proximal musculature. Direct corticospinal projections originate from multiple PMC subdivisions, including PMd and PMv, and account for approximately 30% of the total corticospinal tract axons, terminating in the cervical and lumbosacral enlargements to control posture and gross limb movements.^[1] Indirect pathways, relayed through the medullary reticular formation, further amplify these effects on proximal muscles, providing a parallel route for motor commands that bypasses M1. These spinal outputs are sparser than those from M1 but play a critical role in integrating preparatory signals for movement.^[26]^[28] The PMC also maintains interconnections with the supplementary motor area (SMA), particularly for coordinating complex, bimanual actions. These bidirectional links, involving both ipsilateral and contralateral projections, enable the synchronization of movements across limbs, as evidenced by anatomical tracing in macaques showing dense terminations in SMA layer III. Furthermore, the rostral portion of the dorsal PMC (PMDr) provides sparse yet functionally significant outputs to brainstem structures, such as the pontine nuclei and superior colliculus, supporting eye-head coordination during orienting behaviors.^[29]

History

Early Discoveries

The premotor cortex was first described in the early 20th century through cytoarchitectonic studies of the human cerebral cortex. In 1905, Alfred Walter Campbell identified an intermediate precentral field, located rostrally adjacent to the primary motor cortex, later designated as area 6 by Brodmann in 1909 based on cyto- and myeloarchitectonic criteria distinguishing its layered structure from surrounding regions.^[30] This mapping contributed to early understandings of frontal lobe organization, emphasizing histological variations as indicators of functional specialization. Building on this foundation, Korbinian Brodmann formalized the region in 1909 as the lateral portion of area 6, clearly distinguishing it from the primary motor cortex (area 4) through detailed comparative analysis across species. Brodmann's cytoarchitectonic map highlighted area 6's agranular structure, lacking the prominent inner granular layer of adjacent areas, and positioned it anterior to area 4 on the precentral gyrus, extending across the superior and middle frontal gyri.^[31] This delineation established area 6 as a distinct frontal zone, influencing subsequent neuroanatomical classifications. In 1919, Cécile and Oskar Vogt conducted electrical stimulation experiments in primates that elicited contralateral postural adjustments rather than isolated movements, revealing a field anterior to the primary motor cortex where stimulation produced preparatory tonic responses and supporting the region's role in motor coordination preceding execution. The term "premotor cortex" was first introduced by Marion Hines in 1929.^[32]^[33] Early lesion studies in the 1930s further characterized the premotor cortex's functions through primate experiments. Paul Bucy and John F. Fulton demonstrated that targeted ablations restricted to this area in monkeys, baboons, and chimpanzees resulted in "release" phenomena, including forced grasping—an exaggerated reflexive grip triggered by visual or tactile stimuli—and associated groping behaviors, as part of a broader syndrome involving spasticity and impaired skilled movements.^[34] These findings underscored the premotor cortex's inhibitory role in modulating postural reflexes, linking its integrity to normal motor control.

Modern Developments

Following a period of diminished emphasis in the mid-20th century, when the premotor cortex was often subsumed under a more unified conceptualization of the motor cortex, research revived in the 1980s through neuroimaging advancements that highlighted its distinct roles in motor planning. Positron emission tomography (PET) studies by Roland and colleagues demonstrated selective activation in premotor areas during tasks involving the mental preparation of complex movements, such as sequencing or conditional selection, distinguishing these regions from primary motor cortex activity.^[35]^[36] This revival underscored the premotor cortex's preparatory functions, setting the stage for detailed functional mapping. In the late 1980s and 1990s, Rizzolatti and collaborators advanced premotor cortex research through electrophysiological recordings in macaque monkeys, identifying key subregions within Brodmann's area 6: the dorsal sectors F2 and F7, involved in visually guided reaching and sequencing, and the ventral sectors F4 and F5, associated with spatial coding and grasping actions, respectively.^[37] A landmark discovery in this era was the identification of mirror neurons in area F5, reported by di Pellegrino et al. in 1992, where neurons fired not only during action execution but also during observation of similar actions performed by others, suggesting a mechanism for action understanding. The advent of functional magnetic resonance imaging (fMRI) in the late 1990s and 2000s extended these findings to humans, confirming premotor activation during action observation in a somatotopic manner, with ventral premotor areas responding to observed hand movements akin to monkey F5 mirror responses. This neuroimaging boom integrated premotor functions with broader cognitive processes. Most recently, a 2025 cytoarchitectonic study by Ruland et al., incorporating probabilistic atlases from postmortem brains, refined human premotor parcellation into seven areas (6d1-3 dorsal, 6v1-3 and 6r1 ventral), enhancing precision for cross-species comparisons and functional localization.^[3] Building on mirror neuron discoveries, contemporary research links the premotor cortex to social cognition, positing the mirror system as a neural substrate for empathy and intention understanding, where observed actions evoke simulated motor representations that facilitate emotional resonance and social inference.^[38] This integration has influenced cognitive neuroscience, emphasizing premotor contributions beyond motor control to interpersonal dynamics.^[39]

Clinical Significance

Associated Disorders

Lesions in the left ventral premotor cortex (PMv) are associated with ideomotor apraxia, a disorder characterized by impaired imitation and execution of gestures despite preserved strength and comprehension, often manifesting as spatiotemporal errors in pantomime without underlying motor weakness.^[40] This condition arises from disruptions in the neural networks supporting gesture representation and motor planning, particularly affecting the dominant hemisphere's ability to translate observed actions into coordinated movements.^[41] Bilateral damage to the premotor cortex can lead to forced grasping and spasticity, as classically described in early clinical observations where patients exhibit involuntary grip closure upon tactile stimulation of the palm, coupled with increased muscle tone and difficulty in releasing objects.^[42] These symptoms reflect a release of primitive grasping reflexes due to loss of higher-order inhibitory control from premotor areas, with persistent spasticity emerging specifically from bilateral lesions rather than unilateral ones.^[43] In Parkinson's disease, hypoactivity in the dorsal premotor cortex (PMd) contributes to bradykinesia by impairing movement initiation and phonatory control, evident as reduced neural activation during tasks requiring sustained vowel production and sequential motor actions.^[44] This diminished PMd engagement disrupts the preparatory phases of movement, exacerbating slowness and hesitancy in both limb and vocal motor functions central to the disease's hypokinetic profile.^[45] Following stroke, hyperactivity in the contralesional dorsal premotor cortex (PMd) supports recovery from upper limb impairment, particularly in patients with severe initial deficits, by facilitating compensatory motor planning and execution through increased activation during affected hand movements.^[46] Studies from 2010 demonstrate that this elevated contralesional PMd activity correlates with improved functional outcomes, highlighting its role in adaptive reorganization after hemispheric damage.^[47]

Neuroimaging and Therapeutic Implications

Functional magnetic resonance imaging (fMRI) studies have demonstrated that the dorsal premotor cortex (PMd) exhibits bilateral activation during bimanual tasks, such as coordinated hand movements, reflecting its role in integrating motor planning across hemispheres.^[48] Similarly, positron emission tomography (PET) scans reveal PMd engagement in conditional movement selection, where external cues guide action choices, highlighting its involvement in associative motor learning.^[36] In contrast, the ventral premotor cortex (PMv) shows prominent activation in fMRI paradigms involving action observation, consistent with mirror neuron system recruitment that facilitates imitation and understanding of observed movements.^[49] These activation patterns underscore the distinct yet complementary functions of PMd and PMv in motor control, with bilateral PMd recruitment supporting symmetric task demands and PMv contributing to visuomotor transformations.^[50] Diffusion tensor imaging (DTI) has been instrumental in mapping white matter tracts connecting the premotor cortex to prefrontal regions, revealing disruptions in fractional anisotropy (FA) values in schizophrenia that impair these links and contribute to motor and cognitive deficits.^[51] Specifically, reduced FA in frontal white matter pathways, including those involving premotor-prefrontal projections, correlates with symptom severity in schizophrenia patients, indicating altered structural integrity that affects executive-motor integration.^[52] These connectivity abnormalities, observed in DTI tractography studies, extend to segments derived from the premotor cortex linking to striatal and thalamic structures, further linking microstructural changes to attenuated psychotic symptoms akin to schizophrenia.^[53] Therapeutically, non-invasive transcranial magnetic stimulation (TMS) applied over the contralesional PMd has shown promise in enhancing motor recovery post-stroke by modulating cortical excitability and promoting reorganization of ipsilesional networks.^[46] High-frequency repetitive TMS targeting PMd in chronic stroke patients improves upper limb function, as evidenced by gains in clinical motor scores and reduced interhemispheric inhibition.^[54] For Parkinson's disease, deep brain stimulation (DBS) of basal ganglia targets, such as the subthalamic nucleus, modulates premotor-basal ganglia loops to alleviate bradykinesia and rigidity by normalizing oscillatory activity in these circuits.^[55] This approach disrupts pathological synchronization while preserving premotor contributions to movement initiation, leading to sustained symptom relief in advanced cases.^[56] Recent advancements in 2025 have refined premotor cortex mappings through high-resolution fMRI and intraoperative electrocorticography, improving precision in neurosurgical planning for epilepsy resections near ventral premotor areas involved in speech articulation.^[57] Updated consensus guidelines emphasize task-based fMRI for language mapping, including areas adjacent to the ventral premotor cortex, to reduce risks of postoperative language deficits in patients undergoing resections for drug-resistant epilepsy.^[58] Lesion network mapping using rs-fMRI predicts surgical outcomes by assessing connectivity to motor networks, enabling tailored interventions that may preserve motor function in epilepsy surgery.^[59]

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The syndrome of the premotor cortex in man: impairment of skilled movements, forced grasping, spasticity, and vasomotor disturbance. Brain. 1934. ;. 57. : 69.<|separator|>
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Decorticate Spasticity: A Re-examination using Quantitative ...
Fulton and Kennard (1934) found that premotor ablations resulted only in temporary spasticity, perma- nent spasticity depending upon bilateral removal of both ...
[42]
Premotor cortex is hypoactive during sustained vowel production in ...
Oct 23, 2023 · Our findings suggest that hypoactivation of PMd may be associated with abnormal phonatory control in PD.
[43]
Premotor cortex is hypoactive during sustained vowel production in ...
Our findings suggest that hypoactivation of PMd may be associated with abnormal phonatory control in PD.
[44]
The Role of Contralesional Dorsal Premotor Cortex after Stroke as ...
Sep 8, 2010 · Contralesional PMd is thought to contribute to the support of recovered motor function after stroke, more so in patients with greater impairment.Missing: hyperactivity | Show results with:hyperactivity
[45]
The Role of Contralesional Dorsal Premotor Cortex after Stroke as ...
Contralesional dorsal premotor cortex (cPMd) is more active during movement of the affected hand after stroke compared with in healthy controls (Chollet et al., ...Missing: hyperactivity | Show results with:hyperactivity
[46]
Spatial interference during bimanual coordination: Differential brain ...
Bimanual movements as compared to rest activated a typical bilateral motor network including the dorsal and ventral premotor cortex (PMd and PMv, respectively), ...
[47]
The Activation of the Mirror Neuron System during Action ...
Based on this theory, researchers believe that the motor cortex could be primed by activating the MNS, thus boosting the efficacy of standardized rehabilitation ...
[48]
Movement-Specific Repetition Suppression in Ventral and Dorsal ...
For instance, the ventral premotor cortex (PMv) appears to be involved in processing visuospatial object properties for grasping, whereas the dorsal premotor ...Image Analysis · Results · Imaging Data
[49]
Alterations of Superficial White Matter in Schizophrenia and ... - Nature
Apr 16, 2013 · Diffusion tensor imaging (DTI) can be used to assess SWM in vivo, and compare SWM fractional anisotropy (FA) in schizophrenia patients vs ...Image Processing And... · Swm And Cognitive... · Discussion
[50]
Diffusion Imaging of White Matter In Schizophrenia - PubMed Central
Diffusion tensor imaging (DTI) is a powerful tool for the in-vivo assessment of white matter microstructure. The application of DTI methodologies to the study ...
[51]
Investigating changes in the premotor cortex-derived frontal-striatal ...
Aug 28, 2024 · Our findings highlight the potential role of changes in a segment of the frontal-thalamic pathway derived from the premotor cortex as a biological basis of APS.
[52]
Effects of high frequency rTMS of contralesional dorsal premotor ...
Apr 1, 2022 · Although stroke patients can recover spontaneously, most patients in the chronic phase will still suffer from upper limb dysfunction, especially ...
[53]
Deep Brain Stimulation for Movement Disorders of Basal Ganglia ...
Deep brain stimulation (DBS) is highly effective for both hypo- and hyperkinetic movement disorders of basal ganglia origin.
[54]
Push-pull effects of basal ganglia network in Parkinson's disease ...
Nov 20, 2024 · Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson's disease (PD), but its mechanism remains unclear.
[55]
Mapping the Functional Boundaries of the Speech Articulation
Jul 25, 2025 · Intraoperative mapping further supports this, showing systematic speech arrest in the left or right ventral premotor cortex, independent of ...
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Consensus recommendations for clinical functional MRI applied to ...
Jan 23, 2025 · Ample reports highlight fMRI's added value to guide neurosurgical interventions near brain regions supporting speech and language.
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Prognostic application of lesion network mapping to epilepsy ... - NIH
Mar 5, 2025 · This study describes implementation of lesion network mapping in TSC patients undergoing epilepsy surgery to associate resection zone with seizure outcomes.2.3. Lesion Network Mapping · 3. Results · 4. Discussion