Fact-checked by Grok 2 weeks ago

Primary olfactory cortex

The primary olfactory cortex (POC) is a paleocortical region of the brain located on the ventral surface of the forebrain, serving as the initial and primary site for processing olfactory information received directly from the olfactory bulb via the olfactory tract, bypassing a thalamic relay unlike other sensory pathways.^[1] It encompasses several interconnected structures, including the piriform cortex (a three-layered, pear-shaped area), anterior olfactory nucleus (AON), olfactory tubercle, entorhinal cortex, and portions of the amygdala that receive monosynaptic projections from the olfactory bulb.^[1]^[2] Anatomically, the POC is situated mainly in the medial temporal lobe near the uncus and is accessed via the lateral olfactory stria, with each hemisphere receiving bilateral input from both olfactory bulbs for comprehensive sensory integration.^[1] Its layered organization features superficial layers (Ia and Ib) that receive direct axonal inputs from mitral and tufted cells of the olfactory bulb, while deeper layers (II and III) handle associational fibers for intra-cortical processing.^[3] This structure is evolutionarily conserved across mammals, reflecting its ancient role in odor perception.^[4] Functionally, the POC is essential for odor detection, discrimination, encoding, and recognition, enabling the contextualization of smells through interactions with limbic structures like the amygdala (for emotional valence) and hippocampus (for memory), as well as projections to the orbitofrontal cortex for multisensory integration with taste and vision.^[1]^[5] It also provides feedback projections to the olfactory bulb, modulating sensory input, and contributes to olfactory learning and memory formation via associative pathways.^[6] In humans, functional heterogeneity within the POC—particularly along rostrocaudal axes in the piriform cortex—supports distinct roles in temporal processing of odor stimuli.^[7] Disruptions in POC function are implicated in conditions like anosmia and certain neurodegenerative disorders, underscoring its critical role in sensory and cognitive processing.^[1]

Anatomy

Location and gross structure

The primary olfactory cortex (POC) is defined as the initial cortical destination for direct projections from the olfactory bulb via the lateral olfactory tract, setting it apart from secondary olfactory regions that process more abstracted sensory information.^[1] This structure represents the primary site for early olfactory processing in the mammalian brain.^[8] Anatomically, the POC occupies the ventrolateral surface of the forebrain, specifically within the medial temporal lobe on the inferior aspects of the frontal and temporal lobes.^[5] It lies adjacent to the uncus and parahippocampal gyrus, extending from the anterior olfactory trigone to the limen insulae and forming an integral part of the rhinencephalon, the ancient brain region associated with olfaction.^[9]^[8] Positioned deep and lateral to the lateral olfactory tract, its macroscopic form follows the curvature from the caudolateral frontal lobe around the insula's edge to the rostral dorsomedial temporal lobe.^[8] Unlike the six-layered neocortex, the POC is a three-layered allocortex comprising layer I (a plexiform zone rich in dendrites), layer II (dense with pyramidal cell somata), and layer III (containing deeper pyramidal and nonpyramidal neurons), without a distinct granular layer IV.^[8] This simplified laminar organization underscores its evolutionary role in sensory reception. In humans, the piriform cortex—the predominant component of the POC—measures approximately 0.46–0.51 cm³ per hemisphere based on magnetic resonance imaging volumetrics, with studies observing minor structural asymmetries, including a slightly smaller left hemisphere volume compared to the right.^[10]^[11]

Subregions and cellular composition

The primary olfactory cortex encompasses several distinct subregions that receive direct monosynaptic projections from the olfactory bulb, including the anterior olfactory nucleus (AON), piriform cortex (divided into anterior and posterior portions), periamygdaloid cortex, entorhinal cortex (specifically areas 28 and 34), olfactory tubercle, and transitional zones such as the prepyriform cortex.^[12] The AON, located adjacent to the olfactory bulb, consists of multiple subdivisions that facilitate early integration of olfactory signals across hemispheres via the anterior commissure.^[13] The piriform cortex, the largest subregion, forms a three-layered allocortical structure extending along the medial temporal lobe, with the anterior portion focused on initial sensory processing and the posterior portion involved in associative functions, though detailed roles are beyond anatomical description here.^[14] The periamygdaloid cortex and entorhinal areas receive bulb inputs and bridge to limbic structures, while the olfactory tubercle integrates olfactory and reward-related processing in its striatal-like organization.^[2] The cellular composition of these subregions, particularly the piriform cortex, features pyramidal neurons as the principal output cells, predominantly located in layers II and III and utilizing glutamate as their excitatory neurotransmitter.^[15] Semilunar cells, also glutamatergic, reside superficially in layer IIa and contribute to early feedforward excitation, while deep polymorphic cells in layer III provide diverse morphologies for local integration.^[16] Layer I contains horizontal cells that modulate superficial inputs, and sparse granule cells serve as GABAergic inhibitory interneurons, forming a network that balances excitation with feedback inhibition.^[17] Glial cells, including astrocytes and oligodendrocytes, support synaptic maintenance but are less densely studied in this context compared to neuronal elements.^[18] Histologically, the primary olfactory cortex exhibits a unique three-layered cytoarchitecture, characterized by a dense superficial plexiform layer I where afferent terminations from mitral and tufted cells synapse, subdivided into Ia (distal specific inputs) and Ib (proximal associative fibers).^[15] This structure lacks the granular layer IV typical of neocortex and receives no direct thalamic relay, resulting in a paleocortical organization adapted for rapid, parallel-distributed processing.^[12] Layer II forms a compact band of packed cell bodies, transitioning to the more dispersed layer III, with overall lamination more pronounced in rodents than in primates.^[14] Species variations highlight evolutionary adaptations, with macrosmatic animals like rodents displaying more extensive and well-defined subregions, such as a robust olfactory tubercle and expansive piriform cortex, reflecting heightened olfactory reliance.^[19] In contrast, microsmatic humans show a reduced olfactory tubercle and altered piriform cytoarchitecture, including superficial cell clustering and diminished relative volume, aligning with decreased emphasis on olfaction in primate evolution.^[12] These differences underscore the conserved yet scaled nature of the primary olfactory cortex across mammals.^[20]

Connectivity

Afferent pathways

The primary olfactory cortex receives its principal afferent input through the lateral olfactory tract, comprising axons of mitral and tufted cells from the olfactory bulb that transmit unprocessed odorant signals.^[1]^[21] These projections bypass thalamic relay nuclei, a distinctive feature of the olfactory system that enables direct and rapid cortical access to sensory information, unlike other sensory pathways.^[22] Ipsilateral afferents originate from the anterior olfactory nucleus, which integrates bulb input and sends associative fibers to enhance olfactory processing in the piriform cortex.^[23] Contralateral inputs cross via the anterior commissure, primarily from the contralateral anterior olfactory nucleus and piriform cortex, supporting bilateral olfactory representation.^[24]^[25] Modulatory afferents include noradrenergic fibers from the locus coeruleus, which regulate olfactory discrimination and attention, and serotonergic projections from the raphe nuclei, which modulate sensory gating.^[26]^[27] Afferents from the lateral olfactory tract terminate predominantly in layer Ia of the piriform cortex, synapsing onto distal apical dendrites of pyramidal neurons to initiate cortical odor representation.^[15]^[28] Diffuse projections extend to the entorhinal cortex and periamygdaloid areas, broadening sensory integration within the olfactory network.^[29]^[30] This organization results in distributed representations in the piriform cortex, with limited preservation of glomerular topography, though some topographic cues are maintained in targets like the cortical amygdala.^[31]^[32]

Efferent projections

The primary olfactory cortex, comprising regions such as the piriform cortex, anterior olfactory nucleus, and olfactory tubercle, sends efferent projections to several key brain areas to relay olfactory information for further processing. Major targets include the entorhinal cortex, where projections from the piriform and periamygdaloid cortices contribute to the perforant path, facilitating connections to the hippocampus for memory-related functions.^[13] The orbitofrontal cortex receives both direct corticocortical inputs and indirect relays from the piriform cortex, supporting higher-order olfactory evaluation.^[33] Projections also target the mediodorsal nucleus of the thalamus, which serves as a relay to the orbitofrontal cortex, and extend to the hypothalamus and amygdala for integration with motivational and emotional circuits.^[13] Subregion-specific outputs further diversify these connections. The anterior piriform cortex predominantly projects to the lateral orbitofrontal cortex and agranular insula, while the posterior piriform cortex sends denser projections to the agranular insula.^[33] The olfactory tubercle, in turn, directs outputs to the ventral striatum, linking olfaction to reward pathways.^[34] Feedback loops are prominent, with recurrent projections from the piriform cortex and anterior olfactory nucleus returning to the olfactory bulb and anterior olfactory nucleus itself, enabling gain control and modulation of early sensory processing. These centrifugal fibers primarily originate from pyramidal cells in the olfactory cortex.^[35] The axonal composition of these efferents consists mainly of glutamatergic axons from pyramidal cells, which form excitatory synapses in target regions, though a subset includes GABAergic interneurons providing inhibitory modulation.^[36] ^[37] In humans, efferent projections from the primary olfactory cortex support integration with associative cortical areas like the orbitofrontal cortex, aiding advanced olfactory processing.^[22]^[38]

Physiology and Function

Olfactory signal processing

The primary olfactory cortex, particularly the piriform cortex, processes incoming olfactory signals from the olfactory bulb through sparse coding mechanisms that enable the representation of odor identity. In this scheme, individual odors activate a small fraction—typically less than 10%—of pyramidal neurons across the cortical population, forming distributed ensembles that collectively encode specific odor features. These ensembles arise from the convergent input of mitral and tufted cells onto layer II pyramidal cells, allowing for robust, non-topographic representations that are resilient to noise in sensory inputs.^[39]^[40] Such sparse activity minimizes metabolic costs while maximizing discriminability, as evidenced by in vivo recordings showing that odor-evoked spiking is globally inhibited to sharpen ensemble selectivity.^[41] Temporal dynamics further refine this processing through fast oscillations, including theta (4-8 Hz) and gamma (30-80 Hz) rhythms, which synchronize mitral cell inputs to piriform pyramidal neurons. Respiration-driven gamma oscillations, generated via feedback inhibition from olfactory bulb projections, phase-lock excitatory inputs to enhance the temporal precision of odor encoding, occurring within 100-500 ms of inhalation. Theta rhythms, often coupled to sniffing, facilitate the integration of successive mitral bursts, promoting coherent population activity that supports rapid odor detection and feature binding. These oscillations are critical for maintaining synchrony across distributed ensembles, as disruptions impair the fidelity of signal transmission.^[42]^[43] Plasticity in the piriform cortex underpins odor learning via long-term potentiation (LTP) at synapses between layer I afferents and layer II pyramidal cells, strengthening connections following repeated odor exposure. This LTP, induced by associative pairing of odors with rewards or contexts, follows Hebbian rules where co-active neurons exhibit enhanced synaptic efficacy, as seen in enhanced excitatory postsynaptic potentials persisting for days after training. Such mechanisms enable the stabilization of odor representations, transforming transient bulb inputs into durable cortical memory traces. For instance, early odor preference learning in rodents triggers LTP-like changes at lateral olfactory tract-to-piriform synapses, correlating with behavioral acquisition. Recent studies further elucidate circuit dynamics during olfactory learning, showing reinforced odor representations in the anterior olfactory nucleus that enhance discrimination of familiar odors.^[44]^[45]^[46]^[47] Odor discrimination relies on lateral inhibition mediated by GABAergic interneurons, which suppress overlapping activity in pyramidal ensembles to sharpen distinctions between similar odors. Superficial layer interneurons provide fast feedforward and recurrent inhibition, reducing response variability and enhancing signal-to-noise ratios in odor-selective populations. This process is modeled by basic firing rate dynamics, where the output rate r of a pyramidal neuron is given by

r = \sum_i w_i \cdot input_i + I_{inh},

with w_i as excitatory synaptic weights from mitral inputs, input_i as presynaptic activity, and I_{inh} as inhibitory currents from GABAergic sources; derivations from network models show that increased inhibition amplifies ensemble separation. Experimental blockade of GABA_A receptors disrupts these oscillations and impairs fine odor discrimination, underscoring the role of inhibitory circuits in perceptual acuity.^[48]^[49] In humans, single-neuron recordings from the primary olfactory cortex reveal sparse and selective odor representations similar to those in rodents, with neurons responding to specific odorants within 200-500 ms of stimulus onset, supporting conserved mechanisms of odor encoding across species.^[50]

Integration and modulation

The primary olfactory cortex integrates olfactory information with inputs from other sensory modalities, primarily through connections with the orbitofrontal cortex (OFC), which facilitates cross-modal perception such as associating odors with visual or auditory cues.^[51] These OFC projections to the anterior piriform cortex, a key subregion of the primary olfactory cortex, enable the enhancement of odor identification when combined with non-olfactory stimuli, as demonstrated in electrophysiological studies showing modulated neural responses to congruent multimodal inputs. Additionally, the primary olfactory cortex integrates olfactory signals with intranasal trigeminal inputs, allowing for the perception of irritant qualities in odors like menthol, through overlapping representations in piriform regions.^[52]^[53] Projections from the amygdala to the primary olfactory cortex play a crucial role in emotional tagging, assigning valence to odors by processing their hedonic qualities, such as distinguishing pleasant from unpleasant scents.^[54] This interaction allows the amygdala to influence olfactory representations, where aversive odors elicit heightened amygdala activation that propagates to the piriform cortex, thereby embedding emotional significance into odor perception.^[55] Attentional modulation of the primary olfactory cortex occurs via top-down inputs from the prefrontal cortex, which adjust odor sensitivity based on cognitive demands, enhancing discrimination during focused tasks.^[56] Additionally, cholinergic inputs from the basal forebrain provide preparatory disinhibition of olfactory sensory pathways, improving adaptive attention and response to rewarded odors by amplifying neural excitability in the piriform cortex.^[57] Links between the primary olfactory cortex and the hippocampus support associative memory formation, particularly in odor-reward or odor-fear conditioning, where hippocampal projections to olfactory regions encode contextual associations for long-term retention.^[58] During fear conditioning, sparse ensembles in the piriform cortex are activated to store odor-specific threat memories, integrating with hippocampal circuits to retrieve these associations upon re-exposure.^[59] Recent functional connectomics reveal that subregions of the primary olfactory cortex, such as the anterior olfactory nucleus and piriform cortex, recruit distinct brain-wide networks, with inhibitory circuits shaping divergent signals for sensory processing and behavior. In humans, the primary olfactory cortex forms a large-scale functional network with widespread pathways, supporting integrated chemosensory processing.^[60]^[61] Neuromodulatory effects in the primary olfactory cortex include dopamine release from the ventral tegmental area (VTA), which influences motivational aspects of olfaction by modulating reward-related odor processing in the olfactory tubercle.^[62] This dopaminergic input promotes seeking behaviors toward appetitive odors, enhancing motivational salience. State-dependent gating mechanisms further regulate olfactory discrimination, where heightened arousal states, such as during wakefulness, reduce inhibitory gating in the piriform cortex to improve odor signal transmission and perceptual acuity.^[63]^[64]

Clinical Significance

Associated disorders

The primary olfactory cortex is implicated in several neurodegenerative disorders, particularly Alzheimer's disease (AD) and Parkinson's disease (PD), where early atrophy and pathological protein accumulation contribute to olfactory dysfunction as a prodromal symptom. In AD, hyposmia often precedes cognitive decline, linked to tau and beta-amyloid accumulation in the entorhinal cortex, a key subregion of the primary olfactory cortex, leading to disrupted connectivity between the olfactory bulb and entorhinal areas. Similarly, in PD, hyposmia serves as an early non-motor symptom, with approximately 90% of patients exhibiting olfactory deficits by the time of diagnosis, associated with alpha-synuclein pathology, including Lewy bodies, in subregions such as the olfactory tubercle. These changes reflect the olfactory system's vulnerability to proteinopathies, with neuropathology originating in olfactory structures and propagating to broader brain networks. Epilepsy involving the primary olfactory cortex manifests as temporal lobe seizures, often originating in the piriform cortex due to hyperexcitability and loss of inhibitory signaling within its neural circuits. Chronic disinhibition in the piriform cortex, as observed in kindling models, promotes progressive seizure severity, highlighting its role in limbic epileptogenesis. Traumatic brain injury (TBI) can cause post-traumatic anosmia through shearing forces that damage olfactory tract connections to the primary olfactory cortex, disrupting afferent pathways from the olfactory bulbs. This mechanical injury at the cribriform plate frequently results in permanent olfactory loss, underscoring the cortex's dependence on intact peripheral inputs. Congenital disorders like Kallmann syndrome involve agenesis or hypoplasia of the olfactory bulbs and tracts, extending to reduced volume in the primary olfactory cortex, leading to lifelong anosmia alongside hypogonadotropic hypogonadism. Olfactory dysfunction associated with COVID-19 infection, a prominent example of post-viral anosmia, may involve central mechanisms in the primary olfactory cortex in cases of persistence beyond peripheral recovery, as indicated by altered functional connectivity and volume changes observed in imaging studies as of 2022.^[65]

Diagnostic and therapeutic implications

Functional magnetic resonance imaging (fMRI) is utilized to assess activation patterns in the primary olfactory cortex during odor presentation tasks, revealing reliable responses across varying odor concentrations in healthy individuals.^[66] Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) measures glucose metabolism in the piriform cortex, identifying metabolic changes associated with olfactory processing and disruptions in neurodegenerative models.^[67] Structural MRI detects volume loss in the piriform cortex among patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), correlating with disease progression.^[10] Standardized olfactory tests, such as the University of Pennsylvania Smell Identification Test (UPSIT), evaluate odor identification and correlate with primary olfactory cortex integrity, with lower scores indicating atrophy in conditions like Parkinson's disease (PD).^[68] These assessments provide a non-invasive means to gauge cortical function and predict broader cognitive outcomes.^[69] Olfactory training, involving repeated exposure to specific odors, demonstrates efficacy in improving smell function for post-viral anosmia, including cases following COVID-19 infection, with meta-analyses showing significant recovery rates over 3-6 months.^[70]^[71] Deep brain stimulation targeting the entorhinal cortex, adjacent to the primary olfactory cortex, has rescued memory deficits in AD animal models by enhancing synaptic plasticity and neurogenesis.^[72] Pharmacological interventions like cholinesterase inhibitors, such as donepezil, improve cognitive function in MCI patients, with baseline olfactory deficits predicting greater cognitive gains from treatment.^[73] Olfactory deficits measured by UPSIT predict progression from MCI to AD, conferring a 4- to 5-fold increased risk over 3 years, serving as a prognostic biomarker for early intervention.^[74] Emerging research explores optogenetics in animal models to modulate piriform cortex activity, aiming to restore inhibitory circuits disrupted in olfactory impairments.^[75] Stem cell therapies target regeneration of the olfactory epithelium in congenital defects, potentially extending to cortical support via neural progenitor integration.^[76]

References

[1]
Neuroanatomy, Cranial Nerve 1 (Olfactory) - StatPearls - NCBI - NIH
Aug 14, 2023 · The primary olfactory cortex is the main site of olfactory information processing. The primary olfactory cortex interacts with a wide variety ...
[2]
https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2021.752320/full
[3]
Human Primary Olfactory Amygdala Subregions Form Distinct ...
Three subregions of the amygdala receive monosynaptic projections from the olfactory bulb, making them part of the primary olfactory cortex.
[4]
Development and Organization of the Evolutionarily Conserved ...
Jan 20, 2017 · The olfactory cortex is an evolutionarily conserved paleocortex implicated in odor processing. While several studies addressed how the olfactory ...
[5]
Olfactory Cortex - Physiopedia
The Olfactory Cortex is the portion of the cerebral cortex concerned with the sense of smell. It is part of the Cerebrum.
[6]
Functional Heterogeneity in Human Olfactory Cortex: An Event ...
Dec 15, 2002 · In primary olfactory (piriform) cortex, spatially and temporally dissociable responses were identified along a rostrocaudal axis. A ...
[7]
Olfactory Cortex - an overview | ScienceDirect Topics
It runs just deep to the pial surface, from the olfactory peduncle onto the posterior ventral surface of the frontal lobe and then laterally around the junction ...
[8]
The Olfactory Nerve (CN I) - Pathway - Anosmia - TeachMeAnatomy
### Summary of Primary Olfactory Cortex Location and Gross Structure
[9]
Automatic and manual segmentation of the piriform cortex - NIH
Apr 13, 2023 · We propose a manual segmentation protocol for delineating the human piriform cortex on MR images. We updated the Hammers Atlas Database with ...Missing: cm3 | Show results with:cm3
[10]
MR Volumetric Study of Piriform-Cortical Amygdala and Orbitofrontal ...
Values represent mean ± SD of measured volume (cm3). Post hoc comparisons following multivariate analysis of variance with intracranial volume as covariates ...
[11]
Primary Olfactory Cortex - an overview | ScienceDirect Topics
The primary olfactory cortex refers to brain regions one synapse away from the olfactory bulb, including the piriform cortex, anterior cortical nucleus of the ...
[12]
https://www.sciencedirect.com/topics/neuroscience/primary-olfactory-cortex
[13]
Parallel-distributed Processing in Olfactory Cortex: New Insights ...
Haberly, Parallel-distributed Processing in Olfactory Cortex: New Insights ... This review focuses on PC, which is the largest of the olfactory cortical areas.
[14]
Piriform Cortex - an overview | ScienceDirect Topics
9. Its architecture consists of highly interconnected pyramidal cells, inhibitory gamma-aminobutyric acid (GABAergic) interneurons, and a horizontal arrangement ...Anatomy and Connectivity of... · Neural Plasticity and...
[15]
Mammalian olfactory cortex neurons retain molecular signatures of ...
Aug 14, 2023 · Piriform neurons were grouped into four main neuron types: Vglut1-expressing semilunar (SL) cells, pyramidal (Pyr) cells, Vglut2-expressing ...
[16]
https://www.biorxiv.org/content/10.1101/2023.08.13.553130.full
[17]
https://www.sciencedirect.com/science/article/pii/S0166223613000660
[18]
The olfactory receptor gene repertoire in primates and mouse - PNAS
Primates are thought to have a reduced sense of smell (microsmatic) with respect to other mammals such as dogs or rodents. We have previously demonstrated that ...
[19]
Anatomy of the olfactory system Compared to macrosmatic animals ...
To that end, we used transgenic PS19 mice expressing mutated human tau protein (1N4R isoform, P301S mutation). ... rat's hippocampus and olfactory tubercles, but ...
[20]
Parallel Mitral and Tufted Cell Pathways Route Distinct Odor ...
Jun 6, 2012 · Odor signals are conveyed from the olfactory bulb to the olfactory cortex (OC) by mitral cells (MCs) and tufted cells (TCs). However, whether ...
[21]
Characterizing functional pathways of the human olfactory system
Jul 24, 2019 · Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity ...
[22]
Synaptic Organization of Anterior Olfactory Nucleus Inputs to ...
Dec 2, 2020 · The anterior olfactory nucleus (AON) receives direct input from the olfactory bulb and sends an associative projection to piriform cortex that ...
[23]
Olfactory pathway and nerve: Anatomy | Kenhub
How do we smell? This article describes the anatomy of olfactory pathway and nerve, from the nasal cavity to the brain. Learn this topic now at Kenhub.Olfactory Nerve Pathway · Olfactory Receptor Cells · Clinical Implications
[24]
Contralateral Projections of the Rat Anterior Olfactory Nucleus - PMC
The anterior olfactory nucleus (AON) is a central olfactory cortical structure that has heavy reciprocal connections with both the olfactory bulb (OB) and ...
[25]
Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue ...
Modulation of the Piriform Cortex by Norepinephrine. The LC is the main source of noradrenergic input to the PC, providing a homogeneous distribution of NE ...
[26]
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.908758/full
[27]
Journal of Comparative Neurology - Wiley Online Library
Jul 1, 1973 · The afferent projections to the olfactory cortical areas from the olfactory bulb and the prepiriform cortex have been studied in the rat, ...<|control11|><|separator|>
[28]
Inputs from the olfactory bulb and olfactory cortex to the entorhinal ...
Field potentials and unit activity elicited by electrical stimulation of the olfactory bulb (OB) and anterior and posterior prepiriform cortex (PPCa and PP.Missing: periamygdaloid | Show results with:periamygdaloid
[29]
Periamygdaloid Cortex - an overview | ScienceDirect Topics
In the caudal part of the olfactory cortex, the axons from the olfactory bulb extend into several small areas on the medial surface of the amygdala. The ...
[30]
The organization of projections from olfactory glomeruli onto higher ...
Each odorant receptor corresponds to a unique glomerulus in the brain. Projections from different glomeruli then converge in higher brain regions.
[31]
Nonsensory target-dependent organization of piriform cortex - PNAS
The piriform cortex (PCX) is the largest component of the olfactory cortex and is hypothesized to be the locus of odor object formation.
[32]
Frontiers | Differential Axonal Projection of Mitral and Tufted Cells in the Mouse Main Olfactory System
### Summary of Efferent Projections from Primary Olfactory Cortex
[33]
Cortical Feedback Control of Olfactory Bulb Circuits - ScienceDirect
Dec 20, 2012 · Olfactory cortex pyramidal cells integrate sensory input from olfactory bulb mitral and tufted (M/T) cells and project axons back to the ...
[34]
Glutamatergic Neurons in the Piriform Cortex Influence the Activity of ...
Nov 27, 2019 · The PCX is often referred to as the “primary” olfactory cortex, and extends massive numbers of glutamatergic association fibers throughout the ...Missing: composition | Show results with:composition
[35]
GABAergic neurons in the olfactory cortex projecting to the lateral ...
May 9, 2019 · These results identify novel GABAergic projection neurons in the olfactory cortex that may integrate olfactory sensory and top-down inputs and send inhibitory ...
[36]
Comparative aspects of the olfactory portion of the entorhinal cortex ...
(3) Connectivity: In rodents, the olfactory projection covers the whole extent of the entorhinal cortex, whereas it decreases substantially in macaques, where ...
[37]
Odor representations in olfactory cortex: “sparse” coding, global ...
We show that odors evoke spiking activity that is sparse across the cortical population. We find that unbalanced synaptic excitation and inhibition underlies ...
[38]
Odor identity coding by distributed ensembles of neurons in the ...
A representation of odor identity emerges in piriform ... Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli.
[39]
Odor representations in mammalian cortical circuits - PMC - NIH
Recent studies reveal that odor representations are sparse and highly distributed in the rodent primary olfactory (piriform) cortex.
[40]
Mechanisms and functions of respiration-driven gamma oscillations ...
Feb 20, 2023 · Olfactory bulb mitral-cell projections trigger feedback inhibition-based gamma oscillations in the piriform cortex. After confirming that ...
[41]
Article Upstream γ-synchronization enhances odor processing in ...
Apr 19, 2022 · Increasing MTC γ-synchronization enhances cortical neuron odor-evoked firing rates, reduces response variability, and improves odor ensemble representation.
[42]
A role for the anterior piriform cortex in early odor preference learning
Early Odor Preference Learning Induces LTP-like Changes at the LOT to aPC Synapse. Finally, we examined whether natural odor preference learning induces long ...
[43]
Olfactory Learning-Induced Long-Lasting Enhancement of ...
This remarkable enhancement in learning capability is accompanied by long-term enhancement of synaptic connectivity between piriform cortex (PC) pyramidal ...
[44]
Recurrent circuitry is required to stabilize piriform cortex odor ... - eLife
Jul 14, 2020 · We have described a trial-dependent stabilization of PCx odor representations, which we propose emerges through a Hebbian learning process at ...Missing: pairing | Show results with:pairing
[45]
Odor Representations in Olfactory Cortex: “Sparse” Coding, Global ...
Jun 25, 2009 · Our results reveal that global inhibition and oscillations are major synaptic mechanisms shaping odor representations in olfactory cortex.Oscillatory Synaptic Inputs... · Discussion · Oscillating Synaptic Inputs...
[46]
A transformation from temporal to ensemble coding in a model of ...
Mar 29, 2018 · Our model demonstrates how PCx circuitry can implement multiplexed ensemble-identity/temporal-concentration odor coding.
[47]
Projections from Orbitofrontal Cortex to Anterior Piriform Cortex in ...
The orbitofrontal cortex (OFC) has been characterized as a higher-order, multimodal sensory cortex. Evidence from electrophysiological and behavioral studies in ...
[48]
Chemosensory Convergence on Primary Olfactory Cortex - PMC - NIH
Thus, multisensory populations in amygdala and/or orbitofrontal cortex could indirectly modulate neural activity in olfactory cortex after gustatory stimulation ...
[49]
Integrated Neural Representations of Odor Intensity and Affective ...
Sep 28, 2005 · Our results demonstrate that the amygdala exhibits an intensity-by-valence interaction in olfactory processing. In other words, the effect of ...
[50]
Amygdala activation during aversive olfactory stimulation - PNAS
These findings provide evidence that the human amygdala participates in the hedonic or emotional processing of olfactory stimuli.Emotion, Olfaction, And The... · Results · Discussion
[51]
Olfactory modulation of the medial prefrontal cortex circuitry
(3) The OB receives extensive top-down inputs not only from olfactory cortices, but also from neuromodulatory centers (e.g., serotonin from raphe nuclei ...
[52]
Basal forebrain cholinergic input mediates adaptive attention ...
Basal forebrain cholinergic input mediates adaptive attention ... Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex.
[53]
Hippocampal projections to the anterior olfactory nucleus ... - Nature
Jul 16, 2018 · We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal- ...Missing: conditioning | Show results with:conditioning
[54]
Encoding of Odor Fear Memories in the Mouse Olfactory Cortex
Jan 3, 2019 · We show that olfactory fear conditioning activates sparse and distributed ensembles of neurons in the mouse piriform cortex.
[55]
Activation of the dopaminergic pathway from VTA to the medial ...
Dec 18, 2017 · Our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor- ...
[56]
State-Dependent Sensory Gating in Olfactory Cortex - ScienceDirect
These findings demonstrate a powerful state-dependent gating of odor information in the olfactory cortex that works in synchrony with the gating of other ...Missing: discrimination | Show results with:discrimination
[57]
Behavioral state-dependent changes in the information processing ...
Olfactory cortex shows state-dependent gating of afferent sensory inputs. In the olfactory bulb, granule-to-mitral dendrodendritic synaptic inhibition is ...
[58]
Olfactory fMRI Activation Pattern Across Different Concentrations ...
Jul 30, 2019 · To improve the reliability of olfactory fMRI, we explored the response of primary olfactory cortex (POC) across three different concentrations ...
[59]
Cortical Metabolic Arrangement During Olfactory Processing
Oct 17, 2014 · The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using 18F fluorodeoxyglucose (FDG) ...
[60]
Olfactory-related cortical atrophy is associated ... - PubMed Central
Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction.
[61]
Associations of olfactory function with brain structural and functional ...
Oct 30, 2023 · ... UPSIT was associated with smaller hippocampus and primary olfactory cortex. ... olfactory function and brain tissue microstructural integrity ...2.2. Study Selection · 3. Results · 3.1. Overview
[62]
Efficacy of olfactory training in patients with olfactory loss
The current systematic review and meta-analysis suggests that olfactory training may be an effective intervention for patients with olfactory dysfunction.
[63]
Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits ...
Deep brain stimulation (DBS) has been used to treat a variety of brain disorders and shows promise in alleviating cognitive symptoms in some AD patients (Laxton ...
[64]
Olfactory deficits predict cognitive improvement on donepezil in ...
The findings indicate that olfactory identification deficits represent a potential biomarker to predict response to cholinesterase inhibitor treatment in ...
[65]
Olfactory deficits predict cognitive decline and Alzheimer dementia ...
Odor identification deficits predict the transition from MCI to AD dementia. In a 3-year follow-up study, these deficits were associated with 4 to 5 times ...Missing: progression | Show results with:progression
[66]
Chronic loss of inhibition in piriform cortex following brief, daily ... - NIH
Here, we use optogenetics to briefly activate targeted populations of mouse piriform cortex (PCx) principal neurons in vivo. After just 3 or 4 days of ...Missing: repair | Show results with:repair<|separator|>
[67]
Stem Cells and Cell-Free Therapies for Olfactory Epithelium ...
Sep 16, 2025 · Olfactory impairment can be caused by the degeneration of olfactory receptor neurons in the nose and also by the degeneration of the olfactory ...