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Retained placenta

Retained placenta is an obstetric complication occurring after vaginal delivery, defined as the failure of the placenta to spontaneously separate and expel from the uterus within 30 minutes of fetal birth, or sooner if significant hemorrhage develops.^[1] This condition affects approximately 0.1% to 3% of deliveries worldwide, with higher incidence in developed countries due to active management practices during the third stage of labor.^[1] It arises primarily from the failure of the retroplacental myometrium to contract effectively, which normally shears the placenta from the uterine wall, or from abnormal placental adherence to the decidua.^[2] Key risk factors include prior history of retained placenta, preterm delivery before 34 weeks, high parity (more than five births), uterine anomalies or prior surgeries (such as cesarean sections), and pregnancies resulting from in vitro fertilization (IVF).^[1] The condition is classified into subtypes, such as placenta adherens (due to contractile dysfunction), trapped placenta (from premature cervical closure), and partial placenta accreta (from defective decidualization).^[2] Without prompt intervention, retained placenta is the second leading cause of postpartum hemorrhage, potentially leading to severe blood loss exceeding 500 mL, endometritis, sepsis, or even hysterectomy in extreme cases.^[1] It can also contribute to prolonged hospital stays and increased maternal morbidity, particularly in resource-limited settings where access to care is delayed.^[2] Diagnosis is clinical, based on the absence of placental separation signs (such as the uterus rising or cord shortening) after the standard observation period, often confirmed by ultrasound if needed.^[3] Management typically involves manual removal of the placenta under regional anesthesia or analgesia, with prophylactic antibiotics to prevent infection; adjunctive therapies may include uterotonics like oxytocin or misoprostol to promote contraction and expulsion.^[1] In cases of suspected placenta accreta spectrum, more invasive approaches such as curettage or surgical extraction are employed, and ongoing research explores pharmacological alternatives to reduce the need for manual procedures.^[1] Early recognition and intervention are critical to minimizing complications and supporting maternal recovery.^[3]

Background

Definition

Retained placenta refers to the failure of complete expulsion of the placenta from the uterus within 30 to 60 minutes following delivery of the fetus. This condition disrupts the normal third stage of labor, where the placenta typically separates and is delivered spontaneously due to uterine contractions. Retained placenta is a leading cause of postpartum hemorrhage and maternal morbidity if not addressed promptly.^[4]^[1] The incidence of retained placenta is approximately 2-3% of vaginal deliveries worldwide, with variations depending on factors such as active versus physiological management of the third stage of labor. In settings with active management, the rate is often around 1-2%, while physiological approaches may see higher rates up to 10% in some populations. This prevalence underscores its significance as a common obstetric complication.^[5]^[2]^[6] Retained placenta is classified into three main types based on the underlying mechanism of retention. Placenta adherens occurs when the placenta fails to separate from the uterine wall due to inadequate myometrial contractions behind the placenta. Trapped placenta involves complete separation of the placenta but failure to expel it because it becomes entrapped behind a partially closed cervix. Partial accreta arises from a small area of abnormal attachment preventing full detachment.^[7]^[8]^[9] The condition was first described in 19th-century obstetric literature as a critical cause of postpartum hemorrhage, with early references to "morbidly adherent placenta" highlighting its role in maternal mortality. Historical management evolved from manual extraction techniques illustrated in period medical texts to more standardized interventions in modern practice. In contrast to the normal physiological process of placental delivery, which involves shear forces from uterine contraction leading to expulsion within minutes, retained placenta represents a pathological deviation.^[10]

Physiology of Placental Delivery

The third stage of labor commences immediately following the expulsion of the fetus and concludes with the delivery of the placenta and associated membranes. This phase typically spans 5 to 30 minutes, with a median duration of approximately 6 minutes (interquartile range 4–10 minutes) in uncomplicated vaginal births at term.^[11]^[12] During this period, the uterus undergoes powerful, sustained contractions that facilitate both separation and expulsion, minimizing maternal blood loss through effective hemostasis.^[13] Placental separation primarily results from uterine contractions that reduce the size of the uterine cavity, generating shear forces at the uteroplacental interface. These contractions lead to the formation of a retroplacental hematoma as blood accumulates between the placenta and the uterine wall, further promoting detachment from the center toward the periphery.^[13] Once separated, the placenta is expelled by subsequent myometrial contractions, often aided by maternal pushing or controlled cord traction, with signs including a gush of vaginal blood, cord lengthening, and elevation of the uterine fundus.^[11] This process shears the placenta away from its attachment site, typically requiring only 2–3 additional contractions for complete delivery.^[4] Hormonally, oxytocin plays a central role by binding to myometrial receptors, enhancing the intensity and coordination of contractions to drive separation and expulsion.^[14] Prostaglandins, such as PGF2α, complement this by stimulating myometrial contractility and are produced locally by decidual and placental tissues, with levels peaking shortly after separation.^[13] Concurrently, a functional decline in progesterone—achieved through local metabolic changes and reduced receptor activity—removes inhibitory effects on the myometrium, sustaining contractions post-delivery.^[14] Anatomically, separation occurs at the interface between the chorionic plate and the decidua basalis, where rupture of maternal venous sinuses and decidual septa facilitates detachment.^[13] The contracting myometrium then compresses the underlying spiral arteries and veins, effectively obliterating their lumina and serving as physiological ligatures to staunch bleeding from the placental bed.^[4] This coordinated retraction reduces the placental implantation site, promoting uterine involution and limiting hemorrhage to an average of 200–500 mL.^[11]

Causes and Risk Factors

Pathophysiology

Retained placenta primarily arises from disruptions in the normal process of placental separation, which involves coordinated myometrial contraction and formation of a retroplacental hematoma to create a cleavage plane between the placenta and uterine wall. The most common mechanism is uterine atony, where the retroplacental myometrium fails to contract effectively after delivery of the fetus, preventing the shear forces necessary for detachment; this contractile failure can be visualized via ultrasound as persistent placental contact with the uterine wall.^[2] In such cases, the absence of contraction maintains blood flow to the placental bed, inhibiting the development of the hematoma and leading to persistent adherence.^[2] A second key mechanism involves the failure of retroplacental hematoma formation, which normally results from myometrial contraction compressing uterine vessels and promoting localized bleeding and fibrin deposition to facilitate separation; without this, the placenta remains attached due to the lack of a defined separation plane.^[2] Labor dynamics play a critical role, as prolonged labor or uterine overdistension—such as from multiple gestation or macrosomia—can induce myometrial fatigue, reducing contractility and impairing the expulsion phase of the third stage of labor.^[15] This is exacerbated by excessive oxytocin exposure during labor, which may desensitize myometrial receptors and further compromise contraction efficiency.^[15] At the cellular and molecular level, retained placenta may stem from impaired thrombin generation and fibrin deposition at the placental bed, which are essential for stabilizing the hematoma and completing separation; deficiencies in these processes, potentially linked to coagulation imbalances, prevent effective hemostasis and detachment.^[16] Additionally, molecular factors such as persistent placental production of progesterone or nitric oxide can inhibit myometrial contraction by maintaining a relaxed uterine state.^[2] Retained placenta is also associated with conditions involving abnormal placental adherence, such as placenta previa—where low implantation hinders central separation—or the placenta accreta spectrum disorders, characterized by deficient nitabuch's layer (decidua) allowing direct myometrial invasion by trophoblasts, thus eliminating the natural cleavage plane.^[1] In accreta cases, Doppler imaging reveals sustained vascular flow between the placenta and myometrium, underscoring the adherence pathology.^[2]

Risk Factors

Several obstetric factors increase the risk of retained placenta. A history of previous retained placenta is a significant predictor, with recurrence rates ranging from 3% to 15% in subsequent vaginal deliveries.^[17] Preterm delivery before 37 weeks gestation is associated with a threefold higher incidence compared to term deliveries, particularly in gestations under 27 weeks where the relative risk can reach 6 to 13.^[17] Induced labor, especially with oxytocin, elevates the risk, with odds ratios of 2.0 for moderate durations and up to 6.55 for prolonged use exceeding 415 minutes.^[17] Grand multiparity (more than five births) has been identified as a predisposing element, particularly in association with abnormal placentation.^[1] Prior uterine surgery, such as cesarean sections, and congenital uterine anomalies also increase risk by affecting uterine contractility.^[1] Pregnancies resulting from in vitro fertilization (IVF) are associated with higher incidence.^[1] Uterine abnormalities, such as fibroids, can impede placental separation by altering uterine contractility or occupying space.^[18] Placental factors include placenta previa, which heightens the risk through potential adherence issues like placenta accreta spectrum.^[1] Marginal cord insertion is associated with increased odds of retention, as it may compromise placental detachment during delivery.^[19] Other factors encompass prior manual removal of the placenta, which acts as endometrial trauma and elevates future risk.^[20] Studies have noted a higher incidence among women of Asian ethnicity compared to other groups, potentially linked to genetic or environmental influences.^[21]

Clinical Features

Signs and Symptoms

Retained placenta is primarily identified by the failure to expel the placenta within 30 to 60 minutes after delivery of the baby, marking a prolonged third stage of labor.^[1] This delay occurs when the retroplacental myometrium fails to contract adequately, preventing spontaneous separation and expulsion.^[2] Early signs include the absence of typical placental separation indicators, such as the uterus failing to rise out of the pelvis, no lengthening of the umbilical cord, and lack of a sudden rush of blood from the vagina.^[1] The most common manifestation is postpartum hemorrhage, defined as blood loss exceeding 500 mL, which may present as a continuous trickle or a sudden gush from the vagina.^[1] This bleeding arises due to the open uterine sinuses behind the retained placenta and can escalate rapidly if the placenta is partially fragmented.^[22] Additional signs include uterine tenderness and a boggy uterus upon abdominal palpation, reflecting underlying atony or incomplete separation.^[2] In severe cases, maternal shock may develop, characterized by tachycardia, hypotension, pallor, and difficulty breathing.^[22] Subtle early indicators of complication include a foul-smelling vaginal discharge, suggesting the onset of infection, along with fever or severe pelvic pain.^[23]

Diagnosis

Diagnosis of retained placenta primarily relies on clinical observation during the third stage of labor, where failure of placental expulsion within a specified timeframe indicates potential retention. With active management of the third stage (involving uterotonics and controlled cord traction), retained placenta is typically diagnosed if the placenta is not delivered within 30 minutes of birth, as 98 percent of placentas are expelled by this point. In physiological management (expectant approach without routine interventions), the threshold extends to 60 minutes. This timed assessment allows clinicians to differentiate normal delayed delivery from pathological retention, prompting further evaluation.^[4] Once the placenta is partially or fully delivered, visual inspection is essential to assess completeness. The maternal surface of the placenta must be examined to confirm the presence of all cotyledons; absence of one or more cotyledons or irregular lobulation suggests incomplete separation and retained fragments. Similarly, the fetal membranes should be inspected for large vessels extending beyond the placental edges, which may indicate a succenturiate lobe or other retained portions. This step-by-step examination helps identify discrepancies that could lead to postpartum complications if unaddressed.^[24]^[16] Ultrasound imaging serves as a key confirmatory tool when clinical suspicion persists, particularly if the placenta appears fragmented or bleeding continues. Transabdominal or transvaginal ultrasound can visualize retained products as an echogenic mass or focal endometrial thickening within the uterus, often with associated vascularity on Doppler assessment. The sensitivity of ultrasound for detecting retained tissue varies, ranging from 44 percent immediately postpartum to 75-80 percent at later evaluations, though it is not always required for initial diagnosis and may guide subsequent interventions.^[1]^[25] Laboratory tests support the diagnostic process by quantifying blood loss but are not specific to retention. Measurement of hemoglobin and hematocrit levels helps evaluate the extent of hemorrhage associated with delayed delivery, aiding in overall clinical assessment. Currently, no routine biomarkers are available or recommended for diagnosing retained placenta, as existing research has not identified reliable serum markers for routine use.^[1] Differential diagnosis is crucial to distinguish retained placenta from conditions presenting with similar features, such as postpartum hemorrhage. Uterine atony may mimic retention through failure of uterine contraction and persistent bleeding without visible placental separation, while uterine inversion can present with sudden hemorrhage and a non-expelled placenta due to mechanical entrapment. These distinctions guide appropriate confirmatory steps, such as manual exploration if needed.^[1]

Management

Initial Management

The approach to initial management depends on whether active or physiologic management of the third stage of labor was used. Retained placenta is typically diagnosed after 30 minutes following active management or 60 minutes following physiologic management in a hemodynamically stable patient with minimal bleeding.^[4] Expectant management involves close observation to allow for spontaneous expulsion, with monitoring of vital signs, uterine tone, and blood loss every 15 minutes to detect deterioration early.^[16] Active management of the third stage, if not already initiated, includes administration of oxytocin at a dose of 10 IU intramuscularly or intravenously immediately after delivery of the baby to promote myometrial contraction and aid placental detachment.^[16] Uterotonics facilitate separation without initial invasive intervention.^[1] Controlled cord traction and uterine massage may be applied gently if signs of separation appear.^[16] Supportive care is essential, including intravenous access with crystalloid fluids to maintain volume status and preparation for blood transfusion if estimated blood loss exceeds 500 mL or signs of hypovolemia emerge. Bladder catheterization is advised to facilitate uterine contraction, and continuous monitoring of hemorrhage is critical to guide escalation.^[1]

Advanced Interventions

If the placenta is not delivered within the defined time frame (30 minutes after active management or 60 minutes after physiologic management), advanced interventions are indicated to prevent hemorrhage and infection.^[4] Manual removal of the retained placenta under anesthesia is the primary intervention, typically performed in an operating theater with regional (e.g., spinal or epidural) or general anesthesia. The procedure involves bimanual compression: one hand on the abdominal fundus to stabilize the uterus while the other, inserted vaginally, identifies and extracts the placenta by gently separating it from the uterine wall, using sterile technique to assess completeness and avoid trauma. This method achieves a success rate of approximately 97%, with about 3% of cases requiring further surgical intervention.^[1]^[16] In conjunction with manual removal or in refractory cases, pharmacological aids may be employed if not previously administered. Uterotonics such as ergometrine (0.2–0.5 mg intramuscularly) or misoprostol (600–800 mcg rectally or sublingually) can enhance uterine contractions to facilitate expulsion or aid extraction, though evidence for their standalone efficacy in retained placenta is limited. Prophylactic antibiotics, such as a single dose of cefazolin (1–2 g intravenously), may be considered during or immediately after the procedure due to the risk of infection, but evidence for their benefit in reducing endometritis is uncertain.^[1]^[26] For incomplete removal or retained fragments, surgical options include dilation and curettage (D&C), preferably using suction curettage under ultrasound guidance to minimize trauma and ensure thorough evacuation. In severe cases involving placenta accreta spectrum or uncontrollable postpartum hemorrhage, cesarean hysterectomy—often performed with the placenta left in situ to avoid excessive bleeding—is the definitive treatment, as recommended by guidelines for suspected invasion.^[1]^[27]^[28] Post-procedure care includes vigilant monitoring for infection and hemorrhage, with vital signs assessed every 15 minutes initially, administration of uterotonics to maintain uterine tone, and antibiotics if infection is suspected. Follow-up involves serial hemoglobin checks and transvaginal ultrasound within 1–2 weeks to confirm complete evacuation and rule out retained products.^[16]^[1]

Complications and Prognosis

Complications

Retained placenta is a significant cause of postpartum hemorrhage (PPH), which occurs when the uterus fails to contract effectively due to incomplete placental separation, leading to excessive blood loss.^[1] This hemorrhage can rapidly progress to hypovolemic shock, characterized by tachycardia, hypotension, and tissue hypoperfusion, as blood volume depletion exceeds 20% of total circulating volume.^[29] In severe cases, ongoing hemorrhage triggers disseminated intravascular coagulation (DIC), a consumptive coagulopathy where widespread clotting activation depletes clotting factors and platelets, exacerbating bleeding and potentially leading to multi-organ failure.^[30] Infectious complications arise from bacterial ascension through the cervix into the endometrium, facilitated by the necrotic retained placental tissue serving as a nidus for infection.^[31] This commonly results in endometritis, an inflammation of the uterine lining, with pathogens such as Group B Streptococcus being among the most frequent culprits in postpartum cases.^[32] Untreated endometritis can evolve into systemic sepsis, involving widespread inflammatory response, fever, and hemodynamic instability, which heightens the risk of septic shock and remote organ involvement.^[33] Reproductive consequences often stem from interventions to remove retained placenta, such as aggressive curettage, which can traumatize the endometrial lining and promote scar tissue formation.^[34] This may lead to Asherman's syndrome, characterized by intrauterine adhesions that distort the uterine cavity and impair menstrual function.^[35] Consequently, affected individuals face increased risks of infertility due to obstructed implantation sites or recurrent pregnancy loss.^[36] Retained placenta contributes to postpartum hemorrhage (PPH), the leading cause of maternal mortality worldwide and accounts for nearly 20% of severe PPH cases, with PPH causing approximately 45,000 maternal deaths annually as of 2023, the majority in low-resource settings.^[37]^[38] Prompt management strategies, such as manual removal or uterotonics, are essential to avert these outcomes.^[1]

Prognosis

With timely intervention, most cases of retained placenta resolve successfully, allowing for short-term recovery within days. In uncomplicated scenarios, hospital stays typically last 1 to 3 days following manual removal or other management, enabling discharge once hemorrhage is controlled and vital signs stabilize.^[39] However, delays can lead to prolonged hospitalization due to associated postpartum hemorrhage or infection.^[40] The recurrence risk of retained placenta in subsequent pregnancies ranges from 3% to 15%, with rates approaching 25% in cases linked to prior abnormal placentation such as placenta accreta spectrum.^[1] Women with a history of retained placenta face significantly elevated odds in future vaginal deliveries, particularly if underlying factors like uterine adhesions persist. This risk underscores the importance of preconception counseling and vigilant monitoring in subsequent gestations. Long-term health implications include an increased susceptibility to abnormal placentation in future pregnancies, potentially complicating delivery. Additionally, the experience can contribute to psychological effects, such as postpartum anxiety or fear of recurrence, which may persist and affect maternal mental health.^[41] In high-resource settings, factors like prompt diagnosis and intervention markedly improve prognosis, reducing maternal mortality to less than 1%, compared to higher rates in low-resource areas where access to care is limited.^[42] Overall outcomes are favorable with modern obstetric practices, emphasizing the role of early action in minimizing both immediate and enduring risks.

Other Animals

In Domestic Species

Retained placenta is a significant postpartum condition in domestic animals, particularly in livestock species such as cattle and horses, where it can lead to immediate health risks and long-term reproductive challenges. In dairy cows, the prevalence ranges from 3% to 15% following calving, with an average incidence of approximately 8% across herds, though it can vary widely from 3% to 40% depending on management and nutritional factors.^[43]^[44] This condition is often linked to hypocalcemia, commonly known as milk fever, which impairs uterine contractions necessary for placental expulsion.^[45]^[46] The primary causes in cattle include uterine inertia resulting from hypocalcemia and nutritional deficiencies, such as inadequate selenium and vitamin E levels, which compromise immune function and placental separation.^[47]^[48] In horses, retained fetal membranes occur less frequently, with rates of 2% to 10% in light breeds and up to 30% to 54% in heavy breeds like Friesians, often due to weaker uterine tone or placental abnormalities.^[49]^[50] These factors highlight the role of periparturient metabolic stress in both species. Management strategies emphasize conservative approaches to avoid complications like uterine trauma or infection. In cattle, oxytocin administration (20-50 IU within 24 hours post-calving) is commonly used to stimulate uterine contractions and promote expulsion, often combined with antibiotics to prevent metritis; manual removal is discouraged unless necessary, as it can introduce bacteria and delay healing.^[43]^[51]^[52] For horses, similar oxytocin therapy is standard, with monitoring for up to 3 hours post-foaling before intervention, and surgical removal reserved for prolonged retention.^[53] In severe cases involving dystocia in cattle, fetotomy may be considered pre-delivery to facilitate expulsion, but it is not routine for isolated retained placenta.^[54] The economic impact in livestock production is substantial, with each case in dairy cows costing over $300 due to reduced milk yield, increased veterinary expenses, and delayed conception leading to metritis in 25-50% of affected animals, which can result in reproductive issues.^[43] Preventive measures, such as calcium supplementation and balanced selenium-vitamin E nutrition during the transition period, can maintain incidence below 10% and mitigate these losses.^[44]^[47]

In Wildlife

Retained placenta has been observed in various wild species, though documentation remains limited due to the challenges of observing parturition in natural settings. In African elephants (Loxodonta africana), normal placental expulsion typically occurs within 12 hours postpartum, often shortly after the calf stands, allowing the mother to conceal the afterbirth by covering it with soil to deter scavengers and predators. Delayed or retained placental fragments have been reported in some cases lasting several weeks without immediate fatal consequences to the dam, but field observations in truly wild populations are scarce, with most data derived from semi-managed or zoo environments simulating wild conditions. In primates, such as wild vervet monkeys (Chlorocebus pygerythrus) in urban-adjacent landscapes in South Africa, retained placenta accounted for 15.4% of documented pregnancy complications between 2012 and 2018, with two adult females observed exhibiting weakness and associated injuries or infections post-labor.^[55]^[56]^[57] Potential causes in wildlife include environmental stressors that impair uterine contractions and placental separation. Habitat disruption, such as fragmentation and human encroachment, induces chronic stress in species like bats and other mammals, potentially disrupting reproductive physiology and increasing vulnerability to conditions like retained placenta by elevating glucocorticoid levels that hinder myometrial function. Nutritional stress from seasonal food scarcity or altered foraging patterns in disturbed ecosystems can also contribute, as deficiencies in minerals like selenium and vitamins exacerbate failure of placental detachment, a pattern observed across mammals though more studied in managed populations. In wild contexts, these factors compound without veterinary support, heightening risks during vulnerable postpartum periods.^[58]^[59]^[60] Natural outcomes of retained placenta in wildlife vary by species and context but often involve high mortality risks due to infection, predation, or maternal debilitation. In the observed vervet monkey cases, both females succumbed to complications, including uterine infection.^[57] For elephants, prolonged retention appears more tolerated physiologically, potentially self-resolving over time, but in wild settings, it may prolong maternal immobility at the birth site, indirectly elevating predation risks for the neonate or dam. Evolutionary pressures likely favor rapid placental expulsion in many mammals to minimize exposure to predators; for instance, elephants' prompt burial of the afterbirth reflects an adaptation to conceal birth evidence in predator-rich habitats. Research on these dynamics is constrained by sparse field data, with insights primarily from longitudinal observations in protected areas or captive analogs that approximate wild stressors, highlighting the need for non-invasive monitoring technologies to better elucidate ecological impacts.^[55]^[56]

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Equine pregnancy
Retained placenta. Retained placenta is rare due to the strong uterine contractions and microcotyledonary attachment of the placenta in mares. Retention ...
[52]
[PDF] Uterine diseases in dairy cows: understanding the causes and ...
Uterine diseases such as metritis and endometritis are highly prevalent in high producing dairy cows. These diseases lead to impaired welfare and.
[53]
Propaedeutic and Therapeutic Practices Used for Retained Fetal ...
Mar 29, 2024 · The present study aimed to monitor the practices of European veterinarians for the diagnosis and treatment of retained fetal membranes in cattle.
[54]
Treatment of Retained Fetal Membranes in the Mare—A Practitioner ...
Jun 19, 2018 · Retained fetal membranes (RFM) is a common post-partum problem in mares for which the treatment is highly variable.
[55]
[PDF] Treating and Preventing Retained Placenta in Beef Cattle
It is usually not necessary to manually remove the placenta; however, your veterinarian can advise you better after examining the animal. It is important to ...Missing: oxytocin | Show results with:oxytocin
[56]
Normal birth process | Elephant Medicine
The afterbirth usually comes off within 12 hours. There are a few reports on retained (parts of) placenta for several weeks, without major complications for the ...Preceding Any Recommendation... · Predicting The Time Of... · The Normal Calving Process...<|control11|><|separator|>
[57]
General care and reproductive management of pregnant and infant ...
In one birth at the Camp, release of the placenta did not occur until the 96 hours mark, and a case of retained placenta was suspected. See Table 3. Table 3 ...
[58]
Pregnancy complications in wild vervet monkeys in an urban mosaic ...
Jan 28, 2024 · All pregnancy complications were categorised into either (1) birthing complications, (2) dystocia, and (3) retained placenta. The initial ...
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Habitat disturbance results in chronic stress and impaired health ...
Apr 5, 2017 · We found that some paleotropical bat species from disturbed forests suffered from chronic stress and an impaired immune system.
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mechanism of retained placenta and its treatment by plant medicine ...
The most common causes of ROP are dystocia, caesarian section, maternal hypoimmunity, mal and unbalanced nutrition, stress, hereditary predispositions or ...Missing: disruption | Show results with:disruption
[61]
Understanding the Challenges of Retained Placenta in Animals
Jan 1, 2024 · Nutritional imbalance: Deficiency of vitamin A and mineral like selenium in animal diet also contribute for occurrence of this condition. ...