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Rete testis

The rete testis is a specialized network of interconnected channels and tubules located within the mediastinum of the testis, serving as the primary conduit for transporting spermatozoa from the seminiferous tubules to the efferent ductules and ultimately the epididymis.^[1]^[2] This structure, lined by a simple cuboidal to squamous epithelium, forms at the convergence of straight tubules (tubuli recti) extending from approximately 250 testicular lobules, each containing 1–4 coiled seminiferous tubules.^[3]^[4] In addition to sperm transport, the rete testis plays critical roles in maintaining intratubular pressure, regulating the composition of testicular fluid, and providing a niche for spermatogonial stem cells through its transitional zone with seminiferous tubules.^[4] Embryologically, the rete testis arises from a dual origin involving Sf1-positive gonadal somatic cell precursors around embryonic day 10.5 and differentiating Sertoli cells between days 13.5 and 16.5 in mammalian models, with Pax8 expression specifically marking rete-specific cells.^[4] Its development is regulated by endocrine factors such as retinoic acid, which suppresses Sertoli cell markers like Amh via Nr0b1, and fibroblast growth factor 9 (FGF9), ensuring proper differentiation and connectivity to efferent ducts.^[4] Postnatally, rete epithelium continues to transform from Sertoli-like cells, surrounded by peritubular myoid cells that support structural integrity and fluid dynamics.^[4] Pathologically, disruptions in rete testis function can impair spermatogenesis and fertility, highlighting its essential role in male reproductive physiology.^[4]

Anatomy and structure

Location and macroscopic features

The rete testis is defined as an anastomosing network of delicate tubules located in the hilum of the testicle, specifically within the mediastinum testis.^[5]^[6] It is situated at the posterior superior aspect of the testis, embedded within the mediastinum testis, which forms an incomplete vertical septum on the posterior surface extending from the superior to near the inferior portion of the organ.^[6] This structure lies directly under the tunica albuginea at the cranial pole, adjacent to the testicular hilum.^[7] The rete testis receives input from the straight tubules, or tubuli recti, which receive spermatozoa from approximately 600–1,000 seminiferous tubules via the tubuli recti originating from the ~250 testicular lobules.^[8]^[3] It then drains into 10–15 efferent ductules, also known as ductuli efferentes, which extend to the head of the epididymis.^[6]^[8] Macroscopically, the rete testis appears as a dilated intratesticular structure forming a compact, labyrinthine network of interconnected channels that occupies a small portion of the testicular mediastinum.^[7]^[6] It presents as an echo-poor area on ultrasound imaging.^[9] The rete testis is embedded within the connective tissue septa that divide the testis into approximately 250 lobules, and it maintains close proximity to the testicular blood vessels and nerves traversing the mediastinum.^[8]^[6]

Microscopic features

The rete testis is composed of three distinct parts: a septal (or interlobular) portion consisting of the tubuli recti, a tunical (or mediastinal) portion that forms the primary anastomosing network of channels, and extratesticular extensions known as bullae retis, which can reach up to 3 mm in width.^[10] These components create a complex myoelastic sponge-like structure within the mediastinum testis.^[10] The epithelial lining of the rete testis consists of a simple layer of cuboidal to low columnar cells, varying from flattened to prismatic in height.^[8] These cells exhibit ultrastructural features including numerous slender microvilli on the apical surface of flat, dark variants for potential absorptive functions, occasional cilia on both cell types to facilitate fluid propulsion, and polarized organelles such as mitochondria and Golgi apparatus in lighter prismatic cells.^[11] Lateral cell surfaces show intricate interdigitations with desmosomal attachments, contributing to structural integrity.^[11] A thin basement membrane underlies the epithelium, supported by loose connective tissue stroma.^[12] In the tunical and extratesticular regions, prominent chordae retis—fibroelastic strands 5–40 μm wide and up to over 100 μm long—project into the lumina, containing central myoid cells embedded in an elastic matrix; smaller chordae lack vascularization.^[10] Smooth muscle cells, often surrounding the irregularly shaped cavities, connect to the basement membrane via microfibrillar networks, enabling contractility that may influence channel dynamics.^[11] Ultrastructurally, the rete testis features irregular cavities with minimal to virtually no spermatozoa in normal conditions, distinguishing it from upstream seminiferous tubules.^[11] Flat epithelial cells may resemble endothelial cells due to their attenuated profile and microvillous border, though no significant endocrine cell populations are present.^[11] In humans, the rete testis typically gives rise to 12–15 efferent ductules that emerge from its subdivisions to connect with the epididymis head, though counts can vary up to 20–25 in some individuals.^[8] Epithelial cell height remains consistently low, aligning with cuboidal morphology, without marked regional thickening.^[8]

Embryological development

Cellular origins

The rete testis exhibits a dual cellular origin during prenatal development, with contributions from both coelomic epithelium-derived precursors and differentiating Sertoli cells. One component arises from the coelomic epithelium and early gonadal somatic cell precursors prior to sex determination, which occurs around weeks 6-7 of human gestation. These precursors, originating from the proliferation of coelomic epithelial cells on the ventromedial surface of the mesonephros, form the initial genital ridge and contribute to the somatic framework of the developing gonad.^[13]^[14] The second component derives from differentiating Sertoli cells following sex determination (around E13.5 in mice), which integrate with the Sf1+ precursors to form the rete network and establish connections to mesonephric tubules for efferent duct linkage. This integration supports the structural continuity essential for later sperm transport pathways.^[15]^[16] Key molecular markers for these origins are limited and not entirely unique to rete testis cells. Early somatic precursors express Wt1, a transcription factor involved in gonadal ridge formation from coelomic epithelium around embryonic day 9 in mice (equivalent to human week 6). Pax8 expression marks rete-specific cells in both Sf1+ precursors (from E11.5) and Sertoli-derived components (post-E13.5), distinguishing them from adjacent Sertoli cells. In contrast, Dmrt1, a gene critical for Sertoli cell differentiation, is expressed in developing rete cells but decreases in mature rete cells despite its presence in adjacent supporting cells, highlighting a divergence in cellular identity post-migration.^[15]^[17] Initial formation of the rete testis occurs as flattened, perforated interconnections between the developing rete bridges and mesonephric tubules by embryonic week 8 in humans, marking the transition from primordial structures to a coordinated network. This timing aligns with the differentiation of pre-Sertoli cells and the establishment of basal lamina in testis cords.^[18]^[13] This dual origin is conserved across species, with similar patterns observed in mice and humans through lineage tracing studies. For instance, in mice, Sf1+ cells from coelomic sources at embryonic day 10.5 contribute to the proximal rete, while differentiating Sertoli cells (post-E13.5) contribute to the distal connections, as evidenced by three-dimensional reconstructions and marker analysis.^[19]

Morphogenesis

The morphogenesis of the rete testis initiates during the early stages of human embryonic development, around gestational week 7, when the testis-determining factor (TDF, encoded by SRY) induces the condensation of gonadal cords and the formation of initial anastomotic channels within the medullary region of the gonad. By gestational week 9, the developing rete bridges connect the sex cords to the proximal mesonephric tubules, establishing a primitive rete bridge that serves as the foundational network connecting the developing seminiferous tubules to the excretory ducts. This connection process involves the growth of rete channels toward the mesonephric tubules, with the initial lumens appearing in the tubules at this stage, marking the onset of structural connectivity.^[20]^[21]^[22] In mid-gestation, from approximately weeks 9 to 12, the primitive rete bridge expands into a complex network of anastomosing channels through progressive elongation and branching of the gonadal-derived structures. Sertoli cells, originating from the gonadal ridges, become incorporated into this network to provide epithelial lining and structural support, facilitating the organization of the channels into a perforated, labyrinthine system. Perforation and canalization of the network occur concurrently, transforming the solid cord-like elements into lumenized tubules that ensure patency for fluid flow, with single-cell analyses confirming the persistence of specialized supporting cells (sPAX8+) at the cord poles to mediate this tubulogenesis by post-conception week 9.^[21]^[23]^[23] Hormonal regulation plays a pivotal role in these formative processes, with testosterone secreted by differentiating Leydig cells from around week 8 promoting the stabilization and differentiation of the rete channels and supporting Wolffian duct persistence. Estrogen signaling, mediated via estrogen receptor alpha (ESR1), influences the alignment and branching of the efferent ductules connecting to the rete testis starting from week 12, ensuring proper integration with the mesonephric system.^[24]^[21]^[21] Postnatal development of the rete testis in humans is characterized by minimal morphological changes, with the basic structure completed by birth and only minor remodeling occurring during puberty to accommodate increased luminal diameter and enhanced transport capacity. Disruptions in the canalization process during morphogenesis can result in incomplete lumen formation, potentially leading to cystic dilatations within the rete network.^[4]^[25]

Physiological functions

Role in sperm transport

The rete testis serves as the primary pathway for spermatozoa exiting the seminiferous tubules, where sperm enter through the tubuli recti before converging in this anastomosing network within the mediastinum testis.^[26] As a central confluence point, it collects spermatozoa originating from multiple seminiferous tubules, facilitating their collective transport toward the efferent ductules through the converging fluid flow, which mixes sperm populations from diverse tubular origins.^[27] This structural arrangement ensures efficient channeling of immature, immotile sperm bathed in seminiferous tubular fluid secreted by Sertoli cells.^[28] Sperm transit through this region is brief, typically lasting on the order of minutes to hours, with no evidence of a storage function; instead, the rete testis functions solely as a transient conduit before sperm proceed to the efferent ductules.^[26] The epithelial lining of the rete testis, composed of cuboidal cells with non-motile primary cilia, does not contribute to propulsion via beating. Instead, directional flow is provided by peristaltic contractions of peritubular myoid cells surrounding the seminiferous tubules, which propel sperm-laden fluid into and through the rete toward the efferent ducts.^[29]^[28] These ATP-mediated contractions ensure unidirectional flow.^[28] This transport role is evolutionarily conserved across mammalian species, underscoring its essential contribution to male fertility by ensuring reliable sperm delivery from the testis.^[27]

Fluid and solute dynamics

The rete testis receives a continuous influx of fluid secreted by Sertoli cells within the seminiferous tubules, forming a high-volume, low-viscosity luminal content that transports spermatozoa from the site of production. This fluid is primarily composed of water (approximately 90-95% by volume), rendering it hypotonic to plasma in some aspects while maintaining overall isotonicity, with distinctive electrolyte profiles including elevated potassium levels (about three times plasma concentrations) and reduced sodium and bicarbonate.^[30]^[26] The cuboidal epithelium lining the rete testis facilitates initial fluid reabsorption, absorbing a portion of the incoming volume through apical microvilli and aquaporin water channels, such as AQP1, to begin concentrating spermatozoa prior to their transit into the efferent ductules. This process involves transcellular water movement driven by osmotic gradients established by ion transport, contributing to the overall reduction in fluid volume along the excurrent duct system. In models lacking AQP1, such as knockout mice, rete testis dilation occurs due to impaired water reabsorption, underscoring the channel's role in maintaining luminal dynamics.^[31]^[32]^[33] Solute handling in the rete testis involves selective uptake of ions like sodium (Na⁺) and chloride (Cl⁻), alongside proteins and regulatory molecules such as inhibin, directing them into the systemic circulation via basolateral transport mechanisms. The epithelium helps modulate fluid composition to a neutral pH (around 7.4), removing excess components from the testicular secretion to avert downstream overload in the epididymis. This reabsorption prevents dilution of epididymal milieu and supports efficient sperm maturation.^[30]^[34]^[35] Epithelial function in the rete testis is androgen-dependent, with testosterone promoting maintenance of transport proteins and aquaporin expression to sustain fluid homeostasis. Disruptions, such as those induced by estrogenic models or receptor knockouts, impair reabsorption efficiency, leading to luminal fluid accumulation and potential backpressure on seminiferous tubules.^[36]^[37]

Clinical significance

Pathological conditions

The rete testis is susceptible to a variety of pathological conditions, ranging from benign dilatations and cystic malformations to rare malignancies and reactive changes. Benign conditions include tubular ectasia, characterized by dilation of the rete testis tubules due to obstruction of the efferent ductules, which can arise from epididymal cysts, inflammation, trauma, or post-vasectomy changes.^[38] This condition is often asymptomatic and bilateral in approximately one-third of cases, commonly affecting men over 55 years of age, with an incidence of about 12% in histological studies of elderly autopsy specimens.^[38] Another benign entity is cystic dysplasia of the rete testis, a congenital malformation presenting as irregular cystic spaces within the mediastinum testis, typically manifesting as painless scrotal masses in children with a mean age at diagnosis of around 5 years.^[39] It is rare, with fewer than 70 cases reported, usually unilateral and associated with other genitourinary anomalies.^[39] Cystadenoma of the rete testis represents a further benign cystic growth, arising as a multilocular tumor from the rete epithelium, which may extend intratesticularly or extratesticularly and is typically managed by surgical excision.^[40] Malignant tumors of the rete testis are exceedingly uncommon, with adenocarcinoma being the primary type, originating from the epithelial lining and exhibiting aggressive behavior with a tendency for early metastasis.^[41] This neoplasm accounts for less than 1% of all testicular cancers, predominantly affects men around 60 years of age, and carries a poor prognosis despite radical orchiectomy, with limited response to chemotherapy.^[42] Reactive changes in the rete testis often manifest as hyperplasia, a benign proliferation of epithelial cells that can occur in response to cryptorchidism, where it is a frequent incidental finding in undescended testes, or chronic epididymitis, potentially linked to hormonal or inflammatory stimuli.^[43] Additionally, the rete testis may be invaded by adjacent germ cell tumors, such as seminoma or nonseminomatous types, with invasion present in up to 52% of nonseminomatous cases and serving as an indicator of advanced stage and higher relapse risk.^[44] Congenital anomalies of the rete testis, such as incomplete formation or associated ductal malformations, can lead to obstructive azoospermia by impeding sperm transport, and are sometimes linked to Wolffian duct defects, contributing to infertility in affected individuals.^[45] These anomalies underscore the rete's role in fluid dynamics, where disruptions alter normal solute exchange and pressure gradients.^[45]

Diagnostic and therapeutic applications

The rete testis is visualized on ultrasound as a network of anechoic tubular structures within the mediastinum testis, particularly in cases of tubular ectasia, where it appears as multiple small cystic dilations that are echo-free and extend toward the epididymis.^[38] This imaging finding is crucial for differentiating rete testis ectasia from epididymal cysts, as the former is confined to the central testicular hilum with a striated or branching pattern, whereas the latter presents as well-defined, round anechoic lesions in the epididymal head.^[46] Magnetic resonance imaging (MRI) further aids in tumor delineation involving the rete testis by providing superior soft tissue contrast to assess invasion and distinguish malignant lesions from benign cystic changes, often using T2-weighted sequences to highlight fluid-filled structures.^[47] In germ cell tumors such as seminoma, invasion of the rete testis signifies lymphovascular spread and upgrades the pathologic stage to pT2 or higher, influencing prognosis and treatment decisions by indicating potential for metastatic dissemination beyond the testis.^[48] This staging criterion, established in guidelines like those from the European Association of Urology, underscores the rete testis's role as a critical barrier whose breach correlates with adverse outcomes in testicular cancer management.^[49] Therapeutically, the rete testis serves as an access point for intratesticular injections of spermatogonial stem cells to target the seminiferous tubules, a technique explored in fertility restoration trials for azoospermic patients since the 2010s, including ultrasound-guided approaches that infuse cells directly into the rete for downstream distribution.^[50] These interventions aim to repopulate germ cells in conditions like non-obstructive azoospermia, with preclinical and early-phase studies demonstrating feasibility and sperm retrieval success via rete aspiration.^[51] Biopsy of the rete testis enables histological confirmation of rare malignancies like adenocarcinoma through targeted sampling, often revealing glandular structures with desmoplastic stroma.^[52] Immunohistochemistry supports origin attribution, with tumors typically showing positivity for cytokeratin 7 (CK7), alongside markers like EMA and AE1/AE3, to distinguish rete-derived lesions from other testicular or metastatic adenocarcinomas.^[41] Emerging research highlights the rete testis in infertility diagnostics, where dilation or ectasia on ultrasound, combined with seminal analysis showing low-volume azoospermia or oligospermia, indicates obstructive patterns due to efferent duct blockage, guiding decisions for surgical correction like vasoepididymostomy.^[53] Measurement of rete testis thickness via shear wave elastography further differentiates obstructive from non-obstructive azoospermia, enhancing non-invasive evaluation in male factor infertility.^[54]

History and nomenclature

Historical recognition

The rete testis was first described in the 17th century through early anatomical dissections of the male reproductive tract. In 1668, Regnier de Graaf published a detailed account of the testis, describing it as composed of small convoluted tubules connected to efferent ducts serving as conduits for spermatozoa.^[55] By the mid-19th century, histological advancements formalized these observations; Albert von Kölliker contributed to microscopic descriptions of testicular structures, distinguishing epithelial components in human and mammalian testes.^[56] In the 20th century, technological progress shifted focus to its ultrastructure and developmental origins. Electron microscopy studies in the 1970s revealed the rete's epithelial details, including the presence of cilia on columnar cells that facilitate fluid movement, as documented in examinations of human and rodent tissues.^[10] Developmental research from the 1990s linked the rete testis to mesonephric origins, showing how mesonephric tubules contribute cells and structures during embryogenesis, with key evidence from mouse models indicating migratory cells from the mesonephros integrating into the forming rete around embryonic day 11.5.^[57] Modern milestones have refined its cellular origins and functions through genetic and molecular approaches. In 2009, lineage tracing by Combes et al. demonstrated the rete's dual formation: an initial flattened interconnection from mesonephric tubules, followed by contributions from testicular cords, confirming its hybrid mesonephric-gonadal derivation in mice.^[58] Reviews in 2021 highlighted estrogen's regulatory roles in rete development and maintenance, noting estrogen receptor alpha's expression in rete epithelium influences fluid reabsorption and structural integrity.^[36] A 2025 single-cell analysis identified rete precursors arising from bipotential coelomic epithelial progenitors prior to sex determination, underscoring its early embryonic specification in murine gonads.^[59] The understanding of the rete testis evolved from viewing it as a passive anatomical conduit in 17th-19th century descriptions to recognizing its active role in sperm transport and fluid dynamics by the mid-20th century, driven by physiological studies on ciliary action and epithelial permeability.^[11]

Etymology

The term "rete testis" originates from Latin, where rete translates to "net" and describes the intricate, anastomosing network of tubules it forms within the testis, while testis denotes "testicle" but etymologically derives from the Latin word for "witness," reflecting ancient Roman customs in which men grasped their testicles during oaths to affirm truth and virility, symbolizing male potency.^[60] The designation highlights the structure's macroscopic resemblance to a net, as perceived through early anatomical dissections. First recorded in English anatomical literature in 1777 by M. Falconar, the term emerged in late 18th-century nomenclature, predating widespread microscopy but aligning with observations of the organ's labyrinthine layout by pioneers in reproductive anatomy.^[61] It gained standardization in 19th-century references, notably the inaugural edition of Gray's Anatomy (1858), where it solidified as the conventional label for this testicular component. In comparison to the Greek orchis, meaning "testicle" and derived from Proto-Indo-European roots evoking rounded shapes like tubers (also inspiring the floral term "orchid"), rete testis lacks a direct ancient Greek counterpart, underscoring its Latin foundation in Western medical terminology. This nomenclature endures unaltered in contemporary anatomical and medical texts, maintaining its descriptive precision without evolution.^[5]

References

[1]
Histology at SIU, testis
Feb 4, 2023 · The rete testis in turn leads through numerous small efferent ductules from the mediastinum into the epididymis.
[2]
Male Reproductive System - Duke Histology
The rete testis, the area where tubules coalesce and connect to efferent ductules, is shown as irregularly-shaped lumens lined by a simple cuboidal epithelium.
[3]
Testes - SEER Training Modules
Testes are male gonads that descend to the scrotum, are oval, about 5cm long, and contain seminiferous tubules for sperm production.
[4]
https://doi.org/10.1134/S1062360421060072
[5]
Rete testis: Anatomy, definition and function - Kenhub
The rete testis is an interconnected network of small tubes located in the mediastinum of the testis. It contains sperm cells that travel from the testicle ...
[6]
Testes and Epididymis Anatomy - Medscape Reference
Mar 11, 2025 · The seminiferous tubules converge into straight tubules that lead to the rete testis, a network of interconnected channels located within the ...
[7]
Rete Testis - an overview | ScienceDirect Topics
The rete testis is a dilated intratesticular structure located directly under the tunica albuginea at the cranial pole of the testis.
[8]
Anatomy & histology - Testis & paratestis - Pathology Outlines
Feb 20, 2024 · Connects testicular tubules to 12 - 15 ciliated efferent ducts, which merge into a single duct, the epididymis at its head; Rete lined by ...
[9]
[PDF] Ultrasonography of the scrotum in adults
Feb 21, 2016 · 2 to 3 mm in diameter. Occasionally detected low-level echoes ... Ultrasound appearances of the rete testis. Clin Radiol 1993;47:121 ...
[10]
The human rete testis | Cell and Tissue Research
Three major subdivisions of the rete were distinguished and described: a septal (or interlobular) part represented by tubuli recti, a tunical (or mediastinal) ...<|control11|><|separator|>
[11]
The rete testis in man: Ultrastructural aspects | Cell and Tissue ...
The rete testis cavities are irregularly shaped and contain virtually no spermatozoa. Smooth muscle cells often surround the cavities. In the epithelial lining, ...
[12]
The mammalian rete testis — a morphological examination
The rete testis consists of a series of interconnected wide channels lined with a simple cuboidal to columnar epithelium, resting on a thick basal lamina.Missing: macroscopic | Show results with:macroscopic
[13]
Embryology, Testicle - StatPearls - NCBI Bookshelf - NIH
Apr 24, 2023 · The proliferation of coelomic epithelial cells found on the ventromedial surface of the mesonephroi initiates the formation of the genital ridge ...Missing: origins rete
[14]
Building the mammalian testis: origins, differentiation, assembly
Cell-tracing studies revealed that some cells of the supporting cell lineage originate from the coelomic epithelium overlying the genital ridges (Fig. 5 ...
[15]
The Rete Testis: Development and Role in Testis Function
Dec 19, 2021 · Major, A.T., Estermann, M.A., and Smith, C.A., Anatomy, endocrine regulation, and embryonic development of the rete testis, Endocrinology ...Missing: text | Show results with:text
[16]
We, the developing rete testis, efferent ducts, and Wolffian duct, all ...
The mechanisms by which the rete testis joins the efferent ducts, which joins the Wolffian duct during development, are not known.
[17]
Formation of the rete testis during mouse embryonic development
Aug 27, 2020 · The rete testis connects seminiferous tubules of the testis with efferent ducts having a mesonephric origin. The development of the rete testis ...
[18]
Testis Development - UNSW Embryology
Nov 20, 2019 · Within the developing testis the three main differentiating cell types are: gamete forming cells (spermatogonia), support cells (Sertoli cells) ...Missing: dual | Show results with:dual
[19]
https://doi.org/10.1002/dvdy.21925
[20]
Embryology, Sexual Development - StatPearls - NCBI Bookshelf - NIH
Aug 28, 2023 · Early in male gonadal development, TDF induces the gonadal cords to condense and anastomotic channels to form the rete testis within the medulla ...Missing: origins | Show results with:origins
[21]
https://doi.org/10.1016/j.diff.2020.11.004
[22]
Lecture - Genital Development - UNSW Embryology
Sep 3, 2018 · Week 9 - (56 days) paramesonephric duct fusion (female) ... mesonephric tubules grow towards the testis cords and will form the rete testis.
[23]
Single-cell roadmap of human gonadal development - Nature
Jul 6, 2022 · Somatic cells during sex determination. The coelomic epithelium in the gonadal ridge is the primary source of gonadal somatic cells3,14.
[24]
Testis Development | Endocrine Reviews | Oxford Academic
In this review we describe germ cell specification, differentiation of testicular somatic cells, and disorders that arise from defects in testis development.
[25]
Cystic Dysplasia of the Rete Testis: Case Report and Systematic ...
May 17, 2022 · Cystic dysplasia of the rete testis (CDRT) is a rare cause of testicular masses in children. The pathogenesis of this malformation remains unclear.Missing: incomplete embryonic
[26]
Rete Testis - an overview | ScienceDirect Topics
Smooth muscle cells surround the ductal epithelium ... (a) Seminiferous tubules (ST) are adjacent to the connective tissue around the rete testis complex.
[27]
SOX17-positive rete testis epithelium is required for Sertoli valve ...
Dec 21, 2022 · Major, A. T., Estermann, A. M. & Smith, C. A. Anatomy, endocrine regulation, and embryonic development of the rete testis. Endocrinology 162 ...Missing: text | Show results with:text
[28]
ATP activation of peritubular cells drives testicular sperm transport
We show that coordinated contractions of smooth muscle-like testicular peritubular cells provide the propulsive force for luminal sperm transport toward the ...
[29]
Male reproductive tract cilia beat to a different drummer - PNAS
Jan 28, 2019 · Spermatozoa leave the testis through the rete testis channels, bathed in an abundance of seminiferous tubular fluid. They will then enter ...
[30]
SECRETIONS OF THE TESTIS AND EPIDIDYMIS
fluid do not arise from the germinal cells but probably from the Sertoli cells ... composition of rete testis fluid in the conscious ram. J. Reprod. Fert. 24 ...
[31]
Aquaporins and (in)fertility: More than just water transport
... rete testis when compared to wild type animals. This suggests that AQP1 is crucial for fluid reabsorption in the rete testis [41], possibly due to its ...2. Aquaporins In The Male... · 2.3. Aquaporins In... · 5. Aquaporins In The Female...
[32]
Immunoexpression of aquaporin-1 in the efferent ducts of the rat and ...
Recent data suggest that estrogens play a role in regulating fluid resorption from the efferent ducts, though the biochemical mechanisms involved are unknown.
[33]
Morphology and immunolocalization of aquaporins 1 and 9 in the ...
Nov 4, 2021 · Between 50 and 80% of the testicular fluid is reabsorbed in the efferent ducts (Clulow et al., 1994), but a considerable reabsorption activity ...
[34]
pH and male fertility: making sense on pH homeodynamics ...
Jun 4, 2019 · For instance, it has been described that proteins present in rete testis fluid are associated with sperm protection, such as albumin, clusterin, ...
[35]
pH and bicarbonate in the ductuli efferentes testis of the rat
Dec 24, 2001 · By reabsorbing more than 95% of the testicular bicarbonate output, the efferent ducts contribute substantially to the establishment of the ...
[36]
Estrogens and development of the rete testis, efferent ductules ...
The review focuses on what is known regarding development of the male reproductive tract, from the rete testis to the vas deferens.
[37]
Expression of Aquaporin 9 in the Adult Rat Epididymal Epithelium Is ...
Fluid reabsorption begins in the rete testis, but most of it occurs in the efferent ducts and more distal segments of the excurrent duct system, including ...
[38]
Tubular Ectasia of the Rete Testis: A Diagnostic Dilemma - PMC - NIH
Tubular ectasia of the rete testis is a pathologically benign process with complex and varied aetiology. It must be differentiated from neoplastic disease ...
[39]
Cystic Dysplasia of the Rete Testis: Case Report and Systematic ...
May 18, 2022 · Cystic dysplasia of the rete testis (CDRT) is a rare cause of testicular masses in children. The pathogenesis of this malformation remains unclear.
[40]
Cystadenoma of the rete testis | Radiology Reference Article
Sep 20, 2021 · Cystadenoma of the rete testis is a rare cystic testicular tumor. It does not have specific imaging features, but may be suggested in the differential of a ...
[41]
Adenocarcinoma - Testis & paratestis - Pathology Outlines
Nov 12, 2024 · Primary adenocarcinoma of collecting ducts and rete testis is a rare aggressive neoplasm originating from the epithelium of rete testis ...
[42]
Molecular analysis of adenocarcinomas of the rete testis ... - PubMed
Adenocarcinomas of the rete testis (ACRT) are rare and aggressive testicular neoplasms that present predominantly in older men and have a tendency for early ...
[43]
Adenomatous hyperplasia of the rete testis. A review and ... - PubMed
It is usually an incidental finding in surgical specimens from cryptorchidism and testicular tumour. It can be found in autopsy specimens from patients dying ...
[44]
Testicular hilum and vascular invasion predict advanced clinical ...
Dec 14, 2012 · The presence of rete testis invasion in stage I seminoma patients has been previously found to be an independent risk factor for relapse, in ...
[45]
Tubular ectasia of rete testis with obstructive azoospermia and ...
Dec 11, 2024 · We present a rare case of primary infertility and obstructive azoospermia associated with TERT. We performed extensive literature regarding the possible ...
[46]
Tubular ectasia of rete testis | Radiology Reference Article
Aug 2, 2025 · This is a benign condition thought to result from the partial or complete obliteration of the efferent ducts.Dilated rete testis · Case · Tubular ectasia of the epididymisMissing: goblet | Show results with:goblet
[47]
Testicular Tumors: What Radiologists Need to Know—Differential ...
Mar 12, 2015 · Testicular tumors are usually diagnosed at ultrasonography (US) and are staged at computed tomography (CT) or magnetic resonance (MR) imaging.
[48]
EAU Guidelines on Testicular Cancer - STAGING amp ...
4.1. Staging ; pT2, Tumour limited to testis with vascular/lymphatic invasion, or invading hilar soft tissue or the epididymis or tumour extending through tunica ...
[49]
Seminoma Testicular Cancer Staging - Medscape Reference
Jan 29, 2022 · Seminoma Testicular Cancer Staging ... pT2. Tumor limited to the testis (including rete testis invasion) with lymphovascular invasion ...
[50]
Ultrasound-Guided Rete Testis Approach to Sperm Aspiration and ...
Mar 26, 2025 · Azoospermia (no sperm in the ejaculate) can be caused by genetic mutations, chromosomal abnormalities, medical treatments (e.g., chemotherapy or ...Introduction · Results · Testicular Biopsy And Cell...Missing: congenital | Show results with:congenital
[51]
Ultrasound-Guided Rete Testis Approach to Sperm Aspiration and ...
Mar 26, 2025 · Here we described a noninvasive ultrasound-guided rete testis (UGRT) approach to retrieve sperm from the testes or infuse stem cells into the ...Introduction · Results · Testicular Biopsy And Cell...Missing: transport | Show results with:transport
[52]
Adenocarcinoma of the Rete Testis: A Case Report - PMC - NIH
Feb 14, 2022 · Adenocarcinoma of the rete testis is a rare, aggressive testicular tumor with a mortality rate of 46% and a median survival time of 33 months.
[53]
Ultrasonographic evaluation of the rete testis thickness - NIH
This study aimed to evaluate the ability of rete testis thickness (RTT) and testicular shear wave elastography (SWE) to differentiate obstructive azoospermia ( ...
[54]
Sonography in male infertility: a useful yet underutilized diagnostic tool
Changes along the seminal tract in patients with obstructive cause of infertility a rete testis ectasia and cyst formation in mediastinum testis, b anechoic ...
[55]
The Legacy of Reinier De Graaf - Allen Press
Aug 1, 2000 · In 1668, De Graaf published a classic account of the testicle, which he described to be made of a collection of small tubules. To defend his ...
[56]
Marcello Malpighi (1628-1694) - PubMed
He made many discoveries in the fields of the macro- and microanatomy of the brain, nerves, liver, kidneys, spleen, tegument, lymph nodes, reproductive system ...
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From testis to teratomas: a brief history of male germ cells in mammals
... Kölliker, Franz von Leydig, Enrico Sertoli and Gustaf Retzius (1842-1919) did microscopic observations of testis that marked the history of male germ cells ...
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Mesonephric contribution to testis differentiation in the fetal mouse
Jan 1, 1993 · We conclude that after 11.5 days post coitum, cells can migrate from the mesonephric region into the differentiating testis and can contribute ...
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Single-cell exploration of gonadal somatic cell lineage specification ...
Oct 9, 2025 · A focused analysis of somatic cells uncovered a population of bipotential progenitors derived from the coelomic epithelium of both testes and ...
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Testis - Etymology, Origin & Meaning
Originating in 1704 from Latin testis meaning both "testicle" and "witness," the word signifies a testicle, linked to bearing witness to male virility.
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rete testis, n. meanings, etymology and more | Oxford English ...
The earliest known use of the noun rete testis is in the late 1700s. OED's earliest evidence for rete testis is from 1777, in the writing of M. Falconar.