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Shiitake

The shiitake (Lentinula edodes) is an native to , characterized by its distinctive flavor, meaty texture, and that ranges from 5 to 10 cm in with a tan to dark brown color. As a white-rot fungus belonging to the family Omphalotaceae in the order , it decomposes and is the second most widely cultivated and consumed globally after the button mushroom. Native to the forests of Japan, China, and other East Asian regions, shiitake grows wild on decaying hardwood trees such as oak, beech, and chestnut, thriving in shaded, humid environments with moderate temperatures. Its cultivation originated in East Asia over a thousand years ago, with the earliest records dating back to the 12th century during China's Song Dynasty, when farmers began placing logs in proximity to allow natural spore transfer to produce the fungus intentionally. Today, shiitake is grown worldwide, primarily on hardwood logs or synthetic substrates like sawdust blocks, using spawn inoculation followed by incubation periods of 6 to 18 months before fruiting is induced through soaking or environmental changes. China produces over 80% of the global supply. In the United States, production supported a market valued at around $27 million annually as of 2022, with logs yielding harvests for 3 to 5 years under proper management. Culinary applications of shiitake emphasize its versatility, as it can be consumed fresh, , or powdered, adding depth to soups, stir-fries, and other dishes in Asian and cuisines; enhances its flavor and allows for longer . Nutritionally, it is rich in protein (up to 20% dry weight), (including ), vitamin D2, , and bioactive compounds like and , contributing to its status as a . Beyond nutrition, shiitake has a long history in traditional East Asian for boosting immunity and treating ailments such as colds, , and digestive issues, with modern supporting potential benefits including reduction, antiviral effects, and anti-inflammatory properties from components like lentinan.

Description and Taxonomy

Morphology

The shiitake mushroom (Lentinula edodes) features a distinctive fruiting body that serves as the primary reproductive structure. The , or pileus, measures 5–25 in diameter and starts hemispheric in young specimens, expanding to or nearly flat at maturity. Its color shifts from dark brown when immature to reddish-brown or dark brown with age, often adorned with white flecks or scales that provide a cracked or scaly appearance. Beneath the cap, the gills are white to cream and closely spaced, becoming pinkish-brown with maturity; they are adnate, attaching directly to the . The , or stipe, is central to slightly eccentric, measuring 2–10 cm in length and 0.5–3 cm in thickness, with a fibrous, tough that is white to pale brown and often curved or twisted. No is present in mature specimens. The spores are ovoid to oblong , measuring 5–7 × 3–3.7 μm, , smooth, and inamyloid, producing a pure to when deposited in mass. These basidiospores are borne on basidia within the gills and facilitate dispersal for . The of L. edodes progresses from to fruiting body formation. , initially creamy and cottony-aerial, colonizes substrates over weeks to months, forming a dense that darkens to brown with age or stress. Under triggers like reduced (around 13–18°C for pinning), high (85–95%), and light exposure, hyphal knots develop into primordia or "pins," small protuberances that expand into mature fruiting bodies over 7–14 days. Cultivated forms of shiitake typically exhibit larger, more uniform caps (often 5–10 cm) and stems compared to wild specimens, which display greater variability in size, color intensity, and scale density due to diverse natural substrates and conditions; wild fruiting bodies are generally smaller and more irregular.

Taxonomic Classification

The shiitake mushroom is scientifically classified as Lentinula edodes (Berk.) Pegler within the kingdom Fungi, phylum , class , order , family Omphalotaceae, and genus Lentinula. This classification reflects its placement among wood-decaying basidiomycetes, characterized by gilled fruiting bodies and spore-producing basidia. The common name "shiitake" derives from , where "shii" refers to the hardwood tree (a relative of oaks on which the fungus historically grew) and "take" means mushroom. The genus name Lentinula is a form of Lentinus, derived from the Latin "lentus" meaning tough or pliable, alluding to the resilient texture of the mushroom's stipe. The specific epithet "edodes" comes from "edōdēs," signifying edible, highlighting its long-standing culinary value. Historically, L. edodes has been known by several synonyms, including the basionym Agaricus edodes Berk. (1877), Armillaria edodes (Berk.) Sacc., Cortinellus edodes (Berk.) S. Ito & S. Imai, Cortinellus shiitake (J. Schröt.) Henn., and Lentinus edodes (Berk.) Singer, reflecting shifts in mycological based on morphological and phylogenetic revisions. Phylogenetically, L. edodes belongs to a of wood-decay fungi within the , with close relatives in the genus Lentinula that exhibit lignocellulolytic capabilities for breaking down hardwood substrates. Its evolutionary origins trace to , where it diversified among temperate and subtropical forests, supported by genomic evidence of adaptation to regional climates and hosts. Recent phylogenomic analyses of over 300 Lentinula specimens across Asia, , and the indicate that L. edodes lineages emerged through vicariance and migration, with primary diversification in East and during the . Whole-genome sequencing efforts in the 2010s, including a 2016 assembly of the 41.8 Mb genome encoding approximately 14,889 genes, have revealed genes for carbohydrate-active enzymes and secondary metabolites that underpin its ecological role as a white-rot . Subsequent efforts include a 2022 chromosomal-level of 45.87 Mb for monokaryon L808-1, further elucidating its genetic structure and organization. No formal subspecies are widely recognized, though varietal distinctions such as L. edodes var. edodes denote the typical n strains adapted to broadleaf hardwoods, while cultivated strains exhibit genetic variation for traits like fruiting efficiency.

Ecology and Distribution

Natural Habitat

Shiitake (Lentinula edodes) naturally occurs in the temperate to subtropical broadleaf forests of , including regions of , , , and eastern , where it colonizes dead or decaying hardwood logs and stumps. It preferentially grows on substrates from trees in the family, such as shii ()—from which it derives its —and oaks (Quercus spp.), as well as other hardwoods like (Castanea spp.) and (Fagus spp.). The penetrates the sapwood beneath the bark, breaking down lignocellulosic components including , , and as its primary nutrient sources. These forests provide the humid, shaded conditions essential for L. edodes growth, with optimal temperatures ranging from 10–25°C for mycelial development and cooler ranges of 10–18°C for fruiting initiation. High relative (90–95%) and moderate moisture levels mimic the damp environment, preventing while supporting enzymatic activity. Ecologically, L. edodes functions as a saprotrophic white-rot , contributing to nutrient cycling by decomposing woody debris and releasing essential elements like carbon and into the . It degrades through sequential action of and enzymes, facilitating the breakdown of recalcitrant plant material that other cannot access. While primarily a , research has identified occasional symbiotic associations, such as endomycorrhizal links with certain orchids like Erythrorchis ochobiensis, though it does not form typical mycorrhizal relationships with . In its native , fruiting bodies of L. edodes typically emerge during and autumn, aligned with seasonal shifts to cooler temperatures and increased rainfall that trigger primordia formation on log surfaces. This periodicity enhances spore dispersal in moist conditions while avoiding extreme summer heat or winter cold.

Global Distribution

The shiitake mushroom (Lentinula edodes) is native to East Asia, with its primary natural range encompassing temperate and subtropical forests in countries such as China, Japan, and Korea, where it grows as a wood-decaying fungus on hardwood trees. Phylogenetic analyses indicate that L. edodes lineages are broadly distributed across East and Southeast Asia, originating from tropical or subtropical regions in this area, with diversification occurring over millions of years. Its natural habitat preferences for warm, moist climates with suitable hardwood hosts have historically confined wild occurrences to these Asian locales. Human activities, particularly commercial cultivation, have facilitated the introduction and spread of shiitake to non-native regions worldwide since the late . Cultivation began in during the early 1980s, initially focused on the southern and using logs, leading to established production systems that now contribute significantly to local markets. In and , shiitake cultivation expanded similarly in the 1970s and 1980s through imported spawn and techniques adapted from Asian methods, enabling growth in suitable temperate climates with resources. These introductions were driven by trade in fungal strains and growing demand for gourmet and medicinal mushrooms, resulting in occasional or self-sustaining populations in some introduced areas from escaped cultivations. In native East Asian ranges, wild shiitake populations have experienced declines due to overharvesting for commercial and culinary purposes, exacerbated by loss from and . As a non-native in introduced regions, shiitake exhibits potential for invasive spread by colonizing available substrates, though its impact remains limited compared to other fungi, influenced by suitability and host availability. Key factors shaping its global distribution include international trade in spores and logs, which accelerates dispersal, and climatic variables such as and that determine viable growing zones beyond . As of 2025, countries dominate global shiitake production, accounting for over 80% of both wild and cultivated harvests, with leading as the primary producer due to extensive scale and traditional expertise. This regional concentration underscores the ongoing reliance on native-range techniques, while introduced regions contribute smaller but growing shares through sustainable practices.

Cultivation

Historical Development

The earliest documented evidence of shiitake (Lentinula edodes) cultivation originates from China during the Song Dynasty, with a detailed 185-word description appearing in the Records of Longquan County compiled by He Zhan in 1209. This record outlines early techniques for growing the fungus on hardwood logs, marking the shift from wild foraging to intentional propagation in forested areas. Legend attributes the invention of these methods to Wu San Kwung, a figure honored in temples across Chinese mushroom-growing regions, though historical accounts confirm organized cultivation by the 10th-11th centuries. Native to the damp, deciduous forests of East Asia, shiitake's domestication reflected its ecological adaptation to decaying hardwood, particularly oaks and shii trees. Traditional , known as "natural log ," involved inoculating felled logs—often or —in shaded environments to mimic wild growth conditions. Farmers would strike logs with axes to create wounds for transfer from nearby fruiting bodies or insert mycelium-laden dowels into drilled holes, sealing them with wax before stacking the logs in humid, shaded sites. This labor-intensive process, refined over centuries, yielded variable harvests over 3-5 years per log and formed the backbone of small-scale production in rural communities. In feudal , where shiitake spread by the 13th century via monks, the mushroom held significant economic and cultural value, often serving as a item to lords and symbolizing prosperity in due to its association with and . Key milestones advanced shiitake from artisanal practice to commercial scale. In , the 1796 publication of the first dedicated cultivation guide by horticulturist Chūryō standardized log-based methods, paving the way for broader adoption during the amid growing domestic demand. Commercialization accelerated post-World War II, with significant exports to the beginning in the 1970s after the U.S. Department of Agriculture lifted a long-standing ban on live shiitake spawn imports in 1972, enabling domestic cultivation and market expansion. Genetic breeding programs emerged in the and , focusing on strain selection for higher yields, resistance, and environmental adaptability through techniques like superior varieties and genetic , as detailed in early 2000s research. By the 2020s, shiitake production had transitioned to a global industry, surpassing 10 million tons annually and dominated by , which accounts for over 80% of output through industrialized and methods. As of 2023, global production reached approximately 11 million tons, with 's output exceeding 10 million tons. This scale reflects shiitake's enduring economic role in , where it supports rural livelihoods and , evolving from a forest delicacy to a staple in worldwide .

Modern Techniques

Modern shiitake cultivation primarily relies on prepared substrates such as supplemented with (10-20%) and (1-3%), , or natural logs from species like or sugar maple, which are sterilized through autoclaving or steam treatment to eliminate contaminants before with fungal . involves mixing into the for bag or block cultures or drilling holes into logs and inserting , followed by sealing with wax to prevent external microbial entry. The process unfolds in two main growth phases: , where colonizes the over 6-18 months for logs or 42-84 days for blocks at around 70°F (21°C), including an additional 4-5 weeks for shiitake-specific browning and "popcorning"; and fruiting, triggered by cold shocking (12-24 hours at 34-37°F or 1-3°C) or soaking, lasting 7-14 days under controlled conditions of 60-65°F (15-18°C), over 85% , and indirect . Contemporary systems contrast indoor controlled environments, such as or shelf cultures in climate-regulated rooms that shorten and enable year-round production, with outdoor stacking in shaded areas using or configurations for natural fruiting cycles. Yield optimization in these setups achieves biological efficiencies up to 86-125% on synthetic substrates through high spawn-to-substrate ratios (e.g., 1:40) and proper spacing to enhance and access. Innovations have advanced efficiency with synthetic substrates like supplemented blocks enabling faster colonization compared to traditional logs, automated systems that precisely manage temperature, humidity, and airflow to minimize variability, and of strains—such as Japanese rapid-method varieties developed post-2010—that reduce time by months while maintaining high yields. Key challenges include rigorous contamination control, as molds like or bacterial ingress can occur during high-temperature incubation or inadequate sterilization, often mitigated by sterile lab practices and post-harvest log removal; additionally, concerns arise from reliance on wood resources, prompting shifts toward agro-byproduct substrates and management of spent substrate waste exceeding 100 million tons annually worldwide.

Culinary and Nutritional Uses

Preparation and Culinary Applications

Shiitake mushrooms possess a distinctive -rich flavor profile characterized by savory, earthy notes and a meaty, chewy texture that distinguishes them from milder varieties. This robust taste arises from compounds like , which synergizes with glutamate to amplify savoriness. Drying the mushrooms further enhances this savoriness, as the process concentrates s and breaks down proteins into free , resulting in a more intense umami compared to fresh specimens. Preparation methods for shiitake vary by form and desired outcome. Fresh shiitake can be cleaned by wiping with a damp cloth and then sautéed in oil over medium-high heat for 5-7 minutes until golden and tender, or simmered in soups to infuse broth with their essence. Dried shiitake require reconstitution by soaking in warm water for 20-30 minutes or overnight in cold water to restore pliability while yielding a flavorful ; the soaking liquid can be strained and used in recipes. Powdered shiitake, ground from dried caps, serves as a convenient for rubs or sauces, offering concentrated without rehydration. In culinary traditions, shiitake hold a central role, often dried and simmered to create , a foundational broth that imparts depth to dishes like , where sliced fresh or reconstituted mushrooms add texture alongside and . incorporates shiitake extensively in stir-fries, where sliced fresh or rehydrated mushrooms are wok-tossed with and proteins for a quick, savory dish, or in nourishing broths that blend them with herbs for balanced meals. Western adaptations leverage shiitake's meaty consistency as vegan meat substitutes, such as in bacon-like strips or ground patties, providing a protein-rich alternative in plant-based diets. Shiitake feature prominently in diverse recipes, including risottos where rehydrated slices absorb creamy rice and broth for an earthy twist, and bowls that pair them with noodles, broth, and toppings for umami-layered comfort. They harmonize well with for salinity, for pungency, and greens like or to add freshness and contrast. For storage and preservation, fresh shiitake should be kept in a in the at 41°F, maintaining quality for up to two weeks in a cool, dry, dark environment to prevent moisture buildup. Drying extends shelf life to one year or more when stored in airtight containers away from light and humidity, while freezing blanched or sautéed shiitake preserves them for six months; in offers another option for tangy, shelf-stable preparations lasting up to a year.

Nutritional Composition

Shiitake mushrooms (Lentinula edodes) are low in calories and macronutrients when consumed fresh, with approximately 90% , but their increases significantly upon . Per 100 grams of raw shiitake, the macronutrient profile includes about 2.2 grams of protein, which contains all essential amino acids, 0.5 grams of (primarily unsaturated), and 6.8 grams of carbohydrates, of which 2.5 grams are including beta-glucans. The protein content rises to around 9.6 grams per 100 grams in dried shiitake, with carbohydrates increasing to 75.4 grams (including 11.5 grams of fiber), reflecting the concentration effect of . Micronutrients in shiitake are particularly notable for and minerals. Raw shiitake provides 3.9 milligrams of (24% of the daily value, DV), 0.2 milligrams of (15% DV), and smaller amounts of and . Minerals include 0.14 milligrams of (16% DV), 0.41 milligram of iron (2% DV), and 1.03 milligrams of (9% DV) per 100 grams raw. In dried form, these values scale up substantially: 14.1 milligrams of (88% DV), 5.2 milligrams of (578% DV), 7.7 milligrams of (70% DV), and 36 micrograms of (65% DV) per 100 grams, making dried shiitake a rich source for these s. Variations in nutrient levels can occur due to , cultivation method, and growing conditions, as documented in USDA analyses. Shiitake contains several bioactive compounds, notably and adenine derivatives. Lentinan, a branched , constitutes approximately 0.2-0.3% of the dry weight in the fruiting body, contributing to the mushroom's immunomodulatory properties. Eritadenine, a non-protein derivative, is present at levels around 0.3-0.6% of dry weight (300-600 milligrams per 100 grams), known for its role in . These compounds are more concentrated in dried shiitake, where can reach 8-10% of total weight. The following table summarizes key nutritional components per 100 grams for raw and dried shiitake, based on USDA FoodData Central standards (updated through the with ongoing refinements):
NutrientRaw (per 100g)Dried (per 100g)% (Dried)
Calories34296-
Protein2.2 g9.6 g19%
Total Fat0.5 g1.0 g1%
Carbohydrates6.8 g75.4 g27%
2.5 g11.5 g41%
Niacin (B3)3.9 mg14.1 mg88%
Riboflavin (B2)0.2 mg1.3 mg100%
Copper0.14 mg5.2 mg578%
Zinc1.0 mg7.7 mg70%
Selenium5.7 µg36.3 µg66%
DVs based on a 2,000-calorie for adults. Fresh shiitake's high (88-90%) dilutes these values compared to dried forms, which are commonly used in culinary and supplemental applications for enhanced nutrient delivery.

Medicinal and Therapeutic Applications

Traditional Uses

In , shiitake mushrooms (Lentinula edodes) have been utilized for over a millennium to tonify , nourish blood, and address conditions such as colds, flu, and fatigue, with early records dating to the around 1209 AD. In Japanese medicine, shiitake are similarly employed as a tonic to promote longevity, enhance stamina, and support circulation, reflecting their role in bolstering overall vitality. Specific remedies in East Asian folklore include brewing shiitake into teas to aid digestion and strengthen the stomach, as well as applying them as poultices to soothe wounds and skin ailments. These practices stem from beliefs in the mushroom's ability to promote healing and resolve dampness in the body. Folklore across Asia also attributes longevity-enhancing properties to shiitake, often portraying it as a vital food for extended life and health. In East Asian cultural rituals, shiitake hold symbolic value as emblems of prosperity, good health, and longevity, frequently featured in festival dishes and offered as gifts during celebrations like the Spring Festival to convey wishes for well-being.

Scientific Research

Scientific research on shiitake mushrooms (Lentinula edodes) has primarily focused on their bioactive compounds, such as β-glucans like lentinan and eritadenine, for potential therapeutic applications. Lentinan, a polysaccharide extracted from shiitake fruiting bodies, has been extensively studied for its role in immune modulation, particularly as an adjuvant in cancer therapy. Approved by Japan's Ministry of Health, Labour and Welfare in 1977 for use alongside chemotherapy in gastric cancer patients, lentinan enhances immune responses by activating natural killer cells, T-cells, and macrophages. A 2017 meta-analysis of randomized controlled trials (RCTs) involving advanced cancer patients demonstrated that lentinan combined with chemotherapy improved one-year survival rates by approximately 20% and overall response rates by 15-25%, while reducing chemotherapy-related adverse events. These effects are attributed to lentinan's ability to boost cytokine production and immune cell proliferation, though benefits are most pronounced in gastric and colorectal cancers. In cardiovascular health, eritadenine, a derivative in shiitake, has shown promise in reducing cholesterol levels through inhibition of and promotion of its excretion. Animal studies indicate eritadenine lowers plasma by 20-30% in hypercholesterolemic models by modulating enzymes. Small trials support modest effects; a 1976 study reported a 9-12% in total serum after daily consumption of 9 g dried shiitake (equivalent to 90 g fresh) for one week in healthy young women. A 2021 double-blind RCT observed a 10% in triglycerides after 66 days of shiitake bar consumption in individuals with borderline high . Shiitake extracts exhibit antimicrobial properties , primarily due to and that disrupt microbial cell membranes. Studies have demonstrated inhibition of like Staphylococcus aureus with minimum inhibitory concentrations (MICs) of 1.25-2.5 mg/mL, and antifungal activity against Candida albicans at similar levels. Ethanolic extracts inhibited 85% of tested pathogens, including 50% of yeast and mold species, by compromising formation and activity essential for microbial survival. These findings suggest potential as natural preservatives, though clinical translation remains limited. Recent research in the 2020s has explored shiitake's influence on the and effects via active hexose correlated compound (AHCC), a cultured shiitake mycelial extract. In a 2025 study, shiitake supplementation in a Western diet increased beneficial such as and Lactococcus, modulating the and promoting gut health. AHCC has demonstrated activity by suppressing pro-inflammatory cytokines (e.g., IL-6 and TNF-α) in hepatic fibrosis models. As of 2025, shiitake-derived vesicle-like nanoparticles have been shown to improve cognitive function and reshape and fecal in aged mice. Ongoing clinical trials are investigating shiitake-derived as antiviral adjuncts for , with in vitro data showing inhibition of spike protein binding, though human efficacy data are preliminary. Despite these findings, limitations persist in shiitake research, including poor oral of like lentinan (absorption <1% due to large molecular size) and a reliance on small-scale or rather than large RCTs. Regulatory status varies: lentinan is a in , but shiitake extracts are classified as dietary supplements in the and , lacking standardized dosing or proven therapeutic claims outside adjuncts. More robust, multicenter RCTs are needed to confirm mechanisms and long-term safety.

Safety and Toxicity

Potential Hazards

Consumption of raw or undercooked shiitake mushrooms can trigger shiitake dermatitis, a distinctive flagellate rash characterized by linear, erythematous streaks across the skin, typically appearing 24-72 hours after ingestion. This reaction is attributed to lentinan, a in the mushroom, and is considered a toxic rather than allergic response, affecting an estimated around 2% of individuals who consume undercooked shiitake. The rash is self-limiting, resolving within 1-2 weeks without scarring, but can be pruritic and uncomfortable. Rare cases of true allergic reactions, including , have been documented following shiitake ingestion, particularly in sensitized individuals, with symptoms such as , , and respiratory distress reported in studies from the . Raw or undercooked shiitake mushrooms may cause gastrointestinal disturbances due to their high content, an indigestible in fungal cell walls that can lead to , , abdominal , and in severe cases, vomiting or with elevated stool proteins. Additionally, undigested shiitake fibers have been implicated in rare instances of phytobezoars, resulting in intestinal obstruction requiring medical intervention. Wild-foraged shiitake mushrooms pose risks of with such as , , lead, and mercury, which bioaccumulate in fungal fruiting bodies from polluted environments, potentially exceeding safe intake levels and contributing to long-term . Poorly cultivated shiitake may harbor residues from substrates or growing media, though levels are generally within regulatory limits post-drying; during can introduce s like aflatoxins if and are inadequate. Commercial under regulatory standards minimizes risks, with levels well below safety limits as of 2025. Their immune-modulating properties, driven by compounds like lentinan, could interfere with immunosuppressant therapies by enhancing immune activity, potentially reducing drug efficacy in transplant recipients or those with autoimmune conditions. Cooked shiitake mushrooms are generally considered safe during and in culinary amounts, though consult a healthcare provider for supplemental use or high doses, as potential immune-stimulating effects could pose unknown risks in large quantities. Individuals with should avoid shiitake or use it only under professional supervision to prevent adverse interactions with their condition or treatments.

Consumption Guidelines

For safe consumption of shiitake mushrooms as part of a daily , guidelines from recent clinical studies recommend 5-10 grams of dried shiitake per day, equivalent to approximately 1-5 whole dried caps depending on size, which has been shown to support immune function without adverse effects in healthy adults over short-term periods. For supplemental use, extracts such as AHCC (active hexose correlated compound) derived from shiitake are considered safe at 1-3 grams daily, with longer-term studies supporting up to 3 grams for several years under medical supervision. These dosages align with 2020s research emphasizing moderation to avoid gastrointestinal upset, particularly for those new to mushroom consumption. Preparation is essential to mitigate potential irritants; shiitake should always be cooked thoroughly by , , or other methods reaching at least 150°C for 10-15 minutes to denature compounds like lentinan that can cause reactions. Raw or undercooked shiitake may lead to flagellate dermatitis, a linear rash appearing 24-48 hours post-ingestion, though this is rare with proper cooking. When sourcing shiitake, prioritize certified cultivated varieties over wild-foraged ones to minimize exposure to and pollutants, as wild mushrooms often accumulate higher levels of contaminants like and lead from . Store dried shiitake in a cool, dry place (below 20°C) in airtight containers away from light and moisture to maintain quality for up to a year, preventing growth. For medicinal applications, such as immune support, consult a before incorporating shiitake, especially if pregnant, , or on medications, due to potential interactions. In the , whole shiitake fruiting bodies and basic extracts are not classified as novel foods following regulatory updates in the early , ensuring clear labeling standards for commercial products. Monitor for symptoms like itchy skin rashes, digestive discomfort, or swelling after consumption, and seek medical help immediately if severe reactions such as difficulties occur, as these may indicate or sensitivity.

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