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Skin fold

A skin fold, also referred to as a skinfold, is a natural anatomical feature characterized by the redundancy of skin overlying a permanent crease line, forming a visible overlap or depression on the body's surface.^[1] These folds arise from interactions between the skin and underlying structures, such as the superficial musculoaponeurotic system (SMAS) in facial regions, where morphological changes in connective tissue and fat compartments contribute to their formation.^[2] Skin folds are prominent in flexural or intertriginous areas, including the axillae (armpits), inguinal regions (groin), inframammary folds (beneath the breasts), and abdominal creases, where opposing skin surfaces create environments susceptible to friction, moisture retention, and secondary infections.^[3] Facial examples include the nasolabial fold, which delineates the transition from cheek to perioral areas; the mandibular fold, bordering the lower jaw; and the infraorbital fold, separating the lower eyelid from the cheek.^[2] These features vary by age, body composition, and individual anatomy, with some folds becoming more pronounced due to gravitational effects or subcutaneous fat distribution.^[2] In medical and physiological contexts, skin folds serve practical roles, such as in anthropometry, where caliper measurements of skinfold thickness at sites like the triceps, subscapular, and suprailiac regions estimate subcutaneous adipose tissue and overall body fat percentage.^[4] Clinically, they are significant as sites for dermatological conditions; for instance, intertrigo manifests as erythematous inflammation in these moist, occluded areas, often complicated by bacterial or fungal overgrowth.^[3] Additionally, skin folds can produce radiographic artifacts, such as mimicking pneumothorax on chest X-rays due to superimposed density.^[5]

Terminology and Classification

Definitions

A skin fold is a natural area of redundancy in the skin, characterized by a doubling or layering of the cutaneous tissue over an underlying permanent line, resulting from the interplay of anatomical structures, developmental processes, muscle contractions, and external influences such as gravity.^[1] This redundancy allows the skin to accommodate movement and positional changes without excessive tension, forming a three-dimensional structure that contrasts with flatter skin regions.^[6] For instance, syndromes involving elastic fiber degeneration demonstrate how inherited connective tissue disorders can alter fold formation and prominence.^[1] To distinguish from internal anatomical structures, non-skin folds such as the ileocecal fold—a peritoneal duplication extending from the terminal ileum to the mesoappendix—illustrate similar principles of tissue redundancy but occur in visceral regions rather than the integument.^[7] Note that anatomical skin folds differ from "skinfolds" used in anthropometry, which refer to pinchable subcutaneous fat layers measured at specific sites to estimate body fat.^[8] Skin folds relate to skin creases as the overlying redundancy to fixed dermal attachments, where creases represent permanent lines anchored to underlying fascia.^[1]

Distinctions Between Creases, Folds, and Lines

Skin creases are defined as fixed, permanent lines in the skin that result from attachments of the dermis to underlying structures, such as connective tissue or extensions of muscle fibers, thereby contributing to the establishment of anatomical contours.^[6] According to Dorland’s Illustrated Medical Dictionary (1988), a crease is specifically described as a line or slight linear depression, emphasizing its static and visible nature as an anatomical landmark.^[6] In contrast, skin folds represent areas of redundancy in the skin, often forming as a doubling or recurved margin that allows for flexibility and movement, and they may overlie creases to enhance these properties.^[6] Dorland’s Illustrated Medical Dictionary (1988) characterizes a fold, or plica, as a thin, recurved margin or doubling of tissue, distinguishing it from the more rigid attachment-based formation of creases.^[6] While creases are inherently permanent due to their dermal fixations, folds involve excess skin that can vary in prominence but is not always fixed in the same manner.^[6] Skin lines encompass a broader category of cutaneous markings that are typically dynamic, including tension lines such as Langer's lines, which are linear clefts indicating the orientation of underlying collagen fibers and the direction of maximal skin tension.^[9] Langer's lines, originally described in 1861, reflect the topological arrangement of skin tension and differ from creases by their basis in collagen fiber alignment rather than direct structural attachments.^[10] Wrinkle lines, another subtype, arise from repetitive stress, muscle activity, or aging processes, resulting in temporary or progressive furrows that lack the permanence of creases or the redundancy of folds.^[11] These lines are influenced by factors like expression or environmental stress, setting them apart from the more static creases and folds in both origin and appearance.^[2]

Anatomy and Development

Microscopic Structure

Skin folds exhibit a specialized histological architecture that supports their formation and function, characterized by distinct modifications in the epidermal, dermal, and subcutaneous layers compared to adjacent non-folded skin. The epidermis in these areas typically maintains a standard thin-skin profile, with a thickness of approximately 0.07–0.12 mm, featuring a relatively thin stratum corneum to accommodate flexibility and moisture retention in flexural regions.^[8] However, in specific folds like the nasolabial region, epidermal thickness is approximately 0.06 mm in adjacent upper lip areas.^[12] The dermis in skin folds is notably denser than in non-folded areas, with collagen fibers—predominantly type I and III—arranged in parallel and perpendicular bundles that radiate from the fold crease, facilitating controlled folding and preventing excessive stretching.^[1] Elastin fibers complement this by orienting parallel to the skin surface in the reticular dermis and perpendicular in the papillary layer, providing elastic recoil; these fibers are thickest at the fold's center, enhancing durability in high-movement areas like the inframammary or inguinal creases.^[1] This organized fibroelastic framework contrasts with the more random, less dense arrangement in surrounding flat skin, underscoring the dermis's role in maintaining fold integrity.^[1] Subcutaneous fat in skin folds is compartmentalized by dense connective tissue septa that anchor to underlying muscle fascia, forming supportive partitions which stabilize the fold structure and distribute mechanical loads during movement.^[2] These septa, often part of the superficial musculoaponeurotic system (SMAS) in facial folds, create smaller, denser fat lobules medially (e.g., stronger connections in the upper lip side of the nasolabial fold) compared to larger, fat-filled compartments laterally, promoting the fold's depth and contour.^[2] In trunk folds, this organization manifests as a beehive-like subcutaneous layer, denser near the deep fascia to resist shear forces.^[1] Adnexal structures in skin folds are adapted to the often moist, occluded environment, with a higher density of apocrine sweat glands in intertriginous areas such as the axillae and groin, where they cluster around hair follicles and secrete viscous fluids that can exacerbate humidity but also contribute to local thermoregulation.^[13] Eccrine sweat glands are present throughout but show regional variations, with increased activity in flexural zones to manage perspiration; hair follicles, while sparser in some moist folds like the perineum, are typically vellus-type and associated with sebaceous glands that lubricate the skin surface.^[13] These appendages integrate into the dermal papillae, supporting the fold's sensory and secretory functions without significant deviation from general thin-skin histology.^[13] Vascular and lymphatic drainage in skin folds differs from non-folded skin due to the compact architecture, featuring a richer superficial dermal plexus to supply the high-metabolic adnexa, but with potentially compromised lymphatic flow from apposition of surfaces, leading to fluid accumulation in moist environments.^[14] Arteries and veins form anastomotic networks along the fold axis, ensuring robust perfusion for healing, while lymphatics follow similar dermal paths but drain to regional nodes (e.g., axillary for upper trunk folds), with fold occlusion sometimes impairing clearance compared to open skin areas.^[14] These features trace briefly to embryological folding patterns, where differential tissue growth establishes the oriented connective tissue scaffolds observed in adult folds.^[2]

Embryological Origins

Skin folds originate during embryogenesis primarily through differential growth rates between the epidermis and underlying mesenchymal tissues, leading to mechanical buckling and folding of the skin surface. In mammalian development, the epidermal basal layer undergoes faster proliferation compared to the dermis, generating compressive stresses that initiate crease formation as early as the late embryonic stages. For instance, in the nasal region of developing mammals, excessive basal epidermal growth (e.g., proliferation rates 4-5 times higher than in the dermis) causes the epithelium to buckle between stiffer sub-epidermal structures like blood vessels, resulting in a self-organized polygonal network of creases. This process is evident by embryonic day 38 in dogs and similar timelines in mice and humans, where planar differential growth positions the folds precisely without requiring patterned signaling.^[15] Mesenchymal interactions play a crucial role in guiding and stabilizing these folds, as the dermis provides mechanical resistance and signaling cues that influence epidermal morphogenesis. The underlying mesenchyme, derived from lateral plate mesoderm in limbs and somites in the trunk, interacts with the ectodermally derived epidermis through growth factors and extracellular matrix components, constraining fold positions and preventing excessive deformation. In human fetal development, these interactions are particularly prominent during weeks 8-12, when volar pads emerge on palms and soles, shaping the adjacent flexion creases through localized mesenchymal condensation.^[16]^[17] Apoptosis and cell migration contribute to refining fold patterns, particularly in areas like limb flexures and digital regions, by sculpting tissue architecture and eliminating excess cells to accentuate creases. In limb development, mesenchymal cell migration into flexure zones during weeks 6-10 of gestation establishes the bending sites, while targeted apoptosis in interdigital regions indirectly promotes skin folding by defining joint boundaries. Similarly, in fingerprint ridge formation—a specialized skin fold pattern—apoptosis in the basal layer helps pattern the ridges between weeks 10-16, ensuring precise alignment with underlying dermal papillae. These processes ensure that folds, such as those in elbow and knee flexures, align with functional movement planes.^[18] Postnatally, rapid growth spurts during infancy contribute to the formation of additional transient skin folds, driven by accelerated subcutaneous fat deposition and differential expansion of skin relative to underlying structures. In the first 6-12 months, asymmetric skin folds (e.g., on thighs) can emerge due to uneven soft tissue growth over shorter bones, resolving as proportions normalize. These changes are most pronounced during the infantile growth phase, where weight gain outpaces linear growth, leading to folds in areas like the neck and axillae.^[19] Genetic and heritable factors determine the presence, depth, and patterning of skin folds, with variations linked to specific gene expressions influencing mesenchymal signaling and epidermal proliferation. Flexion creases, for example, develop under primary genetic control, as evidenced by consistent patterns across populations and aberrations in chromosomal disorders like trisomy 21, where a single transverse palmar crease results from altered Hox gene regulation. Heritability is high for crease configurations.^[20]^[16]

Functions and Physiology

Mechanical Roles

Skin folds play a crucial role in facilitating joint flexion and extension by providing excess tissue that allows the skin to bunch up or unfold without tearing or excessive strain during movement. These folds, often manifesting as creases over joints like the elbows and knees, act as natural hinges, enabling the skin to accommodate the range of motion required for bending and straightening. For instance, transverse creases on the fingers represent necessary folding sites near interphalangeal joints, permitting flexion without disrupting the epidermal integrity.^[21] Similarly, palmar creases serve as thinner lines along which the skin folds during metacarpophalangeal joint flexion, effectively partitioning the skin to support hinge-like action.^[22] In areas of high mobility, such as the elbows and knees, skin folds distribute mechanical stress by creating a reserve of tissue that dissipates forces across a broader surface, preventing localized damage during repetitive motions. This redundancy reduces peak tensile stresses on the epidermis and dermis, allowing the skin to elongate with low initial stress before engaging stiffer collagen networks for support. Surface folds in particular provide adaptive buffering, enabling the skin to stretch up to 25% during posture changes like forearm extension without disrupting underlying layers.^[23] By attenuating force concentrations, these structures maintain skin integrity amid the shear and compressive loads inherent to joint articulation.^[24] Skin folds interact with underlying muscles and tendons through connective tissue attachments, such as fascia, to enable coordinated range of motion across the body. As muscles contract and tendons glide during flexion or extension, the folds allow overlying skin to shift synchronously, minimizing drag and facilitating smooth biomechanical transmission from skeletal elements to the surface. This integration ensures that skin deformation aligns with musculoskeletal dynamics, supporting efficient locomotion and manipulation without impeding joint function.^[23] Adaptive responses in skin folds to variations in body habitus, such as increased folding in obesity, accommodate expanded subcutaneous fat layers, preserving mobility despite greater tissue volume. In individuals with higher body mass, larger skin folds form to provide additional redundancy, allowing joints to flex and extend while distributing the augmented mechanical loads from excess weight. This adaptation helps maintain functional range of motion, though it can alter stress patterns in high-mobility regions.^[25]

Sensory and Protective Functions

Mechanoreceptors, such as Merkel cells and Meissner corpuscles, and nociceptors in glabrous skin regions like the palms and fingertips enable enhanced tactile feedback and pain detection during dynamic movements and interactions.^[26]^[27] This innervation supports precise sensory discrimination, allowing for rapid adjustments in grip or posture in response to environmental stimuli. The mechanical support inherent in skin structures further facilitates the even distribution of these sensory elements, optimizing their responsiveness.^[28] Keratin intermediate filaments provide structural resilience, preventing epidermal breakdown under repeated mechanical stress and maintaining overall skin integrity. This adaptation is evident in regions prone to abrasion, where hyperkeratotic responses further reinforce the protective layer without compromising flexibility.^[29] Eccrine glands densely distributed within interfold spaces play a key role in moisture retention and thermoregulation by secreting basal sweat that hydrates the stratum corneum, reducing transepidermal water loss and preserving skin barrier function under normal conditions.^[30] Unlike ridge-located glands activated primarily for evaporative cooling during heat stress, those in folds maintain steady hydration levels, correlating directly with sweat droplet formation to counteract dryness and support antimicrobial defenses at potential entry points for allergens.^[31] This localized glandular activity ensures balanced microenvironments in enclosed fold areas, contributing to homeostasis.

Human Skin Folds

Major Locations and Examples

Skin folds, also known as creases in certain contexts such as digital regions, are prominent features of human cutaneous anatomy that facilitate movement, maintain body contour, and accommodate underlying structures. These folds are categorized by anatomical regions including the axial trunk, limbs, face and neck, and genital and perineal areas. These folds arise from dermal attachments to deeper fascia or muscles, allowing flexibility while preserving form.^[32] Axial folds occur along the trunk and are often horizontal, supporting posture and weight distribution. The abdominal folds, such as the suprapubic crease above the mons pubis, form a zone of strong skin adherence to underlying fascia, becoming more pronounced in obesity where excess adipose tissue creates a pannus or overhanging fold. The gluteal cleft, or intergluteal cleft, is a vertical midline groove separating the buttocks, extending from the sacrum to the perineum and defined by fibrous connections to the gluteus maximus fascia.^[32]^[33]^[34] Limb folds primarily manifest as flexion creases that enable joint mobility. In the upper limb, the antecubital fossa features transverse skin creases at the elbow, where the skin adheres to the bicipital aponeurosis, forming a triangular depression anterior to the joint. The popliteal fossa in the lower limb contains horizontal transverse creases posteriorly at the knee, bounded by hamstring and calf muscles to accommodate flexion. Digital creases on the fingers include proximal, middle, and distal transverse lines, positioned slightly proximal to the interphalangeal joints and anchored to deeper tissues for grip and dexterity.^[32]^[35]^[36]^[37] Facial and neck folds contribute to expression and structural definition. The nasolabial folds are paired oblique creases running from the nasal alae to the oral commissures, formed by dermal extensions of mimetic muscles like the zygomaticus major. The submental fold, a transverse crease beneath the chin, marks the attachment of platysma and neck skin to the hyoid region, delineating the submental compartment. Heritable folds, such as the epicanthic fold—a vertical skin redundancy covering the medial canthus of the upper eyelid—exemplify genetic variations in eyelid morphology, often linked to orbicularis oculi hypertrophy.^[32]^[38]^[39]^[40] Genital and perineal folds protect sensitive structures and allow expansion. The labia majora consist of two longitudinal skin folds extending from the mons pubis to the perineum, comprising adipose tissue and rugose skin homologous to the scrotum. Scrotal skin features multiple rugal folds, thin and elastic layers overlying the dartos muscle, which facilitate thermoregulation and testicular mobility through contraction. These perineal folds, including the oblique groin crease over the hip joint, reflect underlying fascial attachments for regional flexibility.^[41]^[42]^[32]

Variations Across Populations

Skin folds exhibit notable variations across human populations, influenced by factors such as age, sex, ethnicity, and body mass index. These differences arise from a combination of genetic, hormonal, and environmental elements that affect skin structure and elasticity over time. Age-related changes are prominent, with elderly individuals showing increased wrinkles and sagging folds primarily due to the degradation of elastin fibers in the dermis. This loss diminishes the skin's ability to recoil, leading to laxity and the formation of deeper, more persistent folds that contribute to an aged appearance.^[43]^[44] Sex differences manifest in the depth and distribution of folds, with males typically developing deeper folds in regions like the neck and periorbital areas, linked to greater dermal thickness and hormonal influences on collagen density; these often emerge earlier in life as initial signs of aging.^[45]^[46]^[47] Ethnic variations include the higher prevalence of epicanthic folds among East Asian populations, a heritable trait with an embryological basis in eyelid development that affects approximately half of individuals in these groups. This fold, a skin extension over the medial canthus, is far less common in other ethnicities and reflects genetic adaptations distinct to Asian ancestry.^[48]^[40] Body mass index further modulates skin fold prominence; obesity leads to excess folds from accumulated subcutaneous adipose tissue, increasing skinfold thickness as measured by calipers. In contrast, cachexia results in reduced folds due to severe fat and muscle wasting, thinning the subcutaneous layer and diminishing overall skin redundancy.^[49]^[50]

Clinical and Pathological Aspects

Associated Conditions

Skin folds are prone to various inflammatory conditions due to friction and moisture accumulation in these areas. Intertrigo is a common superficial inflammatory dermatitis that occurs in opposing skin surfaces, such as the axillae, groin, and abdominal folds, resulting from skin-on-skin friction and trapped moisture.^[3] Hidradenitis suppurativa is a chronic inflammatory disorder characterized by recurrent painful nodules, abscesses, and sinus tracts, primarily affecting apocrine gland-bearing skin folds like the axillae, groin, and inframammary regions.^[51] The occluded environment of skin folds increases susceptibility to infections, particularly candidiasis caused by Candida species and bacterial infections such as those from Staphylococcus or Streptococcus.^[52] This heightened risk stems from the physiological retention of moisture and warmth in folds, creating an ideal milieu for microbial growth.^[53] Aesthetically, deepening nasolabial folds, which extend from the nose to the mouth corners, are a prominent sign of facial aging due to loss of skin elasticity and volume, often addressed in cosmetology for cosmetic enhancement.^[54]

Diagnostic and Therapeutic Considerations

Diagnosing issues related to skin folds often presents challenges due to their potential to create artifacts on imaging studies. For instance, overlapping skin folds in the hip region can mimic fractures on plain radiographs, a phenomenon sometimes referred to as a hip pseudofracture, which may lead to unnecessary interventions if not carefully evaluated.^[55] In such cases, additional imaging modalities like digital tomosynthesis can help differentiate true osseous pathology from soft tissue overlays by providing clearer visualization of bone structures without superposition artifacts.^[55] Assessment of skin fold thickness plays a key role in non-invasive body composition analysis, particularly for estimating subcutaneous fat and overall body fat percentage. Calipers are the standard tool for this purpose, applied at standardized sites such as the triceps, abdomen, thigh, and suprailiac region to measure the compressed thickness of skin and underlying fat in millimeters.^[56] These measurements are then inputted into validated equations, like those developed by Jackson and Pollock, to derive body density and fat estimates, offering a cost-effective alternative to more advanced techniques like dual-energy X-ray absorptiometry, though they require trained operators for reliability.^[57] Common pitfalls include variability in caliper type and technician technique, with reported differences up to 12% in body fat estimates between caliper types.^[56] Therapeutic management of skin fold-related complications focuses on addressing infections and structural excesses. Infections within folds, often presenting as intertrigo with erythema and maceration, are commonly treated with topical antifungals such as clotrimazole or ketoconazole creams applied twice daily for 2-4 weeks to target candidal overgrowth.^[3] For severe or refractory cases, if involving extensive fungal infection, systemic antifungals such as fluconazole may be used; for bacterial superinfection, systemic antibiotics along with low-potency topical steroids may be added to reduce inflammation.^[3] In patients with significant excess skin folds causing chronic irritation or functional impairment, surgical excision via panniculectomy removes the pendulous abdominal apron, improving hygiene and reducing infection risk; this procedure typically involves transverse incision and lipectomy.^[58] Preventive strategies emphasize meticulous hygiene to mitigate moisture accumulation and friction in skin folds, thereby averting inflammatory conditions like intertrigo. Daily cleansing with mild soap followed by thorough drying, application of barrier creams or powders (e.g., zinc oxide), and selection of loose, breathable clothing are recommended to maintain a dry environment and minimize microbial proliferation.^[3] For individuals at higher risk, such as those with obesity, weight management and absorbent dressings in dependent folds further reduce incidence by promoting airflow and reducing shear forces.^[53]

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Syndactyly - StatPearls - NCBI Bookshelf
Sep 18, 2022 · Syndactyly is a common congenital anomaly in which adjacent digits fail to separate properly, leading to soft tissue or bony fusion, primarily affecting the ...Introduction · Epidemiology · History and Physical · Treatment / Management
[59]
Aplasia Cutis Congenita - StatPearls - NCBI Bookshelf - NIH
Aug 19, 2025 · Aplasia cutis congenita (ACC) is a rare congenital absence of skin, involving the epidermis, dermis, and, occasionally, subcutaneous tissue.Missing: folds | Show results with:folds
[60]
Nasolabial Folds (Smile Lines): Causes & Treatment, Prevention
They're also called smile lines or laugh lines. The creases can become prominent and permanent as you age, especially if you smoke or don't protect your skin ...Symptoms And Causes · Management And Treatment · Living WithMissing: concerns | Show results with:concerns
[61]
Emphasizing the Diagnostic Value of Digital Tomosynthesis in ... - NIH
An 82-year-old woman underwent radiography (A) of the left hip that show no fracture; however, there are overlapping skin folds potentially mimicking a fracture ...
[62]
Skinfold calipers: which instrument to use? - PMC - NIH
Jul 20, 2023 · This study is a brief report that critically examines the original and illustrated structural configuration of the three main types of skinfold calipers.
[63]
Comparison of Skinfold Thickness Measured by Caliper and ... - NIH
Dec 4, 2022 · The measurements of skin fat folds with a caliper showed a higher value of subcutaneous tissue compared to ultrasound measurements. Only the ...
[64]
Panniculectomy - StatPearls - NCBI Bookshelf - NIH
A panniculectomy is an operative procedure used for abdominal wall contouring, changing the shape and form of the abdomen by removing significant excess skin.