Strontium chloride is an inorganic compound with the chemical formulaSrCl₂ and a molecular weight of 158.52 g/mol. It exists as a white, crystalline, odorless solid that is highly soluble in water. The compound has a melting point of 874 °C and a boiling point of 1250 °C.[1][2][3]Strontium chloride serves as a key source of strontium ions in various applications due to its solubility and compatibility with chloride-based systems. In pyrotechnics, it is employed to produce vibrant red flames in fireworks and flares by emitting characteristic light when heated. It is also used as a precursor for synthesizing other strontium compounds, in glass manufacturing, and in metallurgical processes.[3][2]A notable medical application involves its radioactive isotope, strontium-89 chloride, which is administered intravenously to alleviate bone pain in patients with metastatic cancers that have spread to the bones. In dental care, non-radioactive strontium chloride is incorporated into toothpastes to treat dentin hypersensitivity by forming a protective barrier over exposed microscopic tubules in teeth. The compound is generally less toxic than analogous barium chloride but can cause skin, eye, and respiratory irritation upon exposure.[4][1][2]
Properties
Physical properties
Strontium chloride is available in both anhydrous and hexahydrate forms, each exhibiting distinct physical characteristics that influence its handling and applications. The anhydrous form appears as a white crystalline solid and is odorless.[2][5] Its molar mass is 158.53 g/mol, with a density of 3.052 g/cm³.[2][6] The compound melts at 874 °C and has a boiling point of 1,250 °C.[7][2] It is highly soluble in water, with a solubility of 53.8 g/100 mL at 20 °C.[8] The anhydrous form is hygroscopic, readily absorbing moisture from the air, and remains stable under standard conditions.[2][7]The hexahydrate form, SrCl₂·6H₂O, manifests as colorless crystals and is also odorless.[9][10] It possesses a molar mass of 266.62 g/mol and a density of 1.930 g/cm³ at 20 °C.[9][10] The hexahydrate dehydrates at 61 °C upon rapid heating, though it can exhibit a higher melting point of around 115 °C under certain conditions.[11][12] Its solubility in water is 106 g/100 mL at 0 °C, increasing to 206 g/100 mL at 40 °C.[13] Like the anhydrous form, the hexahydrate is hygroscopic and effloresces in air, but it maintains stability under standard ambient conditions.[9][14] The hexahydrate crystallizes in the trigonal system, often forming prismatic habits.[15]Strontium chloride's physical properties, particularly its high water solubility, follow trends observed in analogous alkaline earth metal chlorides like calcium chloride.[2]
Chemical properties
Strontium chloride is a highly ionic compound composed of Sr²⁺ cations and Cl⁻ anions, characteristic of alkaline earth metal chlorides.[1] This ionic bonding results in strong electrostatic interactions, with the larger Sr²⁺ ion exhibiting higher coordination numbers compared to smaller group 2 analogs like Ca²⁺, though lower than Ba²⁺ due to increasing ionic radii down the group.[3]In aqueous solutions, strontium chloride dissociates completely to form neutral solutions with a pH near 7, reflecting minimal hydrolysis as it derives from a strong acid (HCl) and the relatively weak base Sr(OH)₂, unlike more hydrolyzable transition metal chlorides.[16] The compound's chemical properties lie intermediate between those of calcium chloride, which shows lower solubility and reactivity in some contexts, and barium chloride, which displays greater toxicity and solubility trends influenced by the larger barium ion.[17]Strontium maintains a stable +2 oxidation state in the chloride, with no tendency for redox changes under standard conditions, though the chloride ions facilitate electrolytic decomposition to strontium metal and chlorine gas.[3] Thermally, it remains stable up to its melting point of 874°C, beyond which it can volatilize as SrCl₂ gas at the boiling point of 1250°C without immediate decomposition, though further heating may lead to dissociation into elemental strontium and chlorine.[2]Regarding solubility, strontium chloride is highly soluble in water, slightly soluble in ethanol and acetone, and insoluble in liquid ammonia, adhering to general rules for ionic chlorides of group 2 metals.[2] Its solubility in water exceeds 50 g/100 mL at room temperature, enabling its use in various chemical processes.[1]
Occurrence and Production
Natural occurrence
Strontium is a naturally occurring element in the Earth's crust, with an average abundance of approximately 0.034% by weight, ranking it as the 15th most abundant element.[18] This element is primarily concentrated in two minerals: celestite (SrSO₄), which accounts for the majority of strontium production, and strontianite (SrCO₃), a rarer carbonate form.[18] Celestite is the dominant source, forming in sedimentary deposits through evaporative processes, while strontianite typically occurs in low-temperature hydrothermal veins or limestone cavities.[19]Global strontium resources exceed one billion metric tons, with reserves of about 1.47 million metric tons concentrated primarily in China (1 million tons), Iran (200,000 tons), Spain (40,000 tons), Mexico (20,000 tons), the United States (10,000 tons), and other countries (200,000 tons), as of 2023.[20] Iran leads as the world's largest producer of celestite, followed by Spain, China, and Mexico, which together supply nearly all global output as of 2023.[20] These deposits often form in marine evaporite basins or alkaline igneous environments, where strontium substitutes for calcium in mineral lattices due to their similar ionic radii.[21] For instance, strontianite frequently co-occurs with calcium-bearing minerals, as seen in historical specimens from Strontian, Scotland, where the mineral was first identified and named.[22]Strontium chloride (SrCl₂) does not occur naturally and is entirely synthetic, as strontium halides are rare in geological settings; chloride's high solubility and mobility in aqueous solutions prevent stable mineral formation under typical Earth surface conditions.[18] Instead, strontium cycles through the environment primarily via rock weathering, releasing ions into soils and waters, from which it is taken up by biota.[23] This process enables bioaccumulation in plants, where strontium substitutes for calcium in cellular structures, and in aquatic organisms like shellfish, which incorporate it into their calcium carbonate shells.[24] Such cycling maintains low but persistent environmental levels, influencing ecosystems without forming chloride compounds in situ.[25]
Production methods
Strontium chloride is commonly prepared in laboratories by reacting strontium hydroxide or strontium carbonate with hydrochloric acid. The reaction with strontium hydroxide proceeds as follows:
\ce{Sr(OH)2 + 2HCl -> SrCl2 + 2H2O}
Similarly, the reaction with strontium carbonate yields:
\ce{SrCO3 + 2HCl -> SrCl2 + CO2 + H2O}
These methods produce an aqueous solution of strontium chloride, which can be crystallized to obtain the solid form.[26][5]Upon cooling the aqueous solution, strontium chloride typically crystallizes as the hexahydrate, \ce{SrCl2 \cdot 6H2O}, due to its high solubility at room temperature decreasing in colder conditions. To obtain the anhydrous form, the hexahydrate is dehydrated by heating, with dehydration occurring in stages starting above 61 °C and completing at approximately 320 °C under controlled conditions to avoid decomposition.[5][27]Industrial production of strontium chloride primarily starts from celestite ore (\ce{SrSO4}), the main natural source of strontium. One common method involves roasting celestite with coke to form strontium sulfide (\ce{SrS}), followed by reaction with hydrochloric acid:
\ce{SrS + 2HCl -> SrCl2 + H2S}
An alternative direct process leaches crushed celestite with hot concentrated hydrochloric acid:
\ce{SrSO4 + 2HCl -> SrCl2 + H2SO4}
This approach is efficient for large-scale operations, though it requires handling the byproduct sulfuric acid.[28][29]Purification of strontium chloride involves recrystallization from aqueous solutions to remove impurities like calcium or barium salts, or vacuum drying for the anhydrous product to eliminate residual water without thermal degradation. These steps ensure high purity for applications requiring it as an intermediate in strontium compound synthesis.[30][31]Global production of strontium compounds, including strontium chloride as a key intermediate, is derived from approximately 520,000 metric tons of celestite mined annually as of 2023, with major producers being Iran, Spain, China, and Mexico. Strontium chloride itself accounts for a portion of this, supporting the estimated market value of around USD 380 million in 2025.[20][32]Strontium chloride was first prepared following the discovery and early isolation of strontium compounds around 1790 from strontianite, with early syntheses occurring in the late 18th and early 19th centuries, notably through acid treatments similar to modern laboratory methods, prior to Humphry Davy's electrolytic isolation of metallic strontium in 1808 using a strontium chloride mixture.[33][34]
Structure
Crystal structure
Strontium chloride exists in both anhydrous and hydrated forms, each exhibiting distinct crystal structures determined through X-ray and neutrondiffraction techniques.The anhydrous form, SrCl₂, adopts the fluorite (CaF₂-type) structure, characterized by a face-centered cubic lattice in the space group Fm-3m (No. 225). In this arrangement, Sr²⁺ cations occupy the corners and face centers of the cubic unit cell, while Cl⁻ anions are positioned at the tetrahedral voids, ensuring a three-dimensional ionic framework.[35] Each Sr²⁺ ion is coordinated to eight Cl⁻ ions in a cubic geometry, and each Cl⁻ ion is tetrahedrally coordinated to four Sr²⁺ ions, reflecting the compound's predominantly ionic bonding character.[36] The lattice parameter a is 6.9744 Å at room temperature, as determined experimentally. X-raydiffraction data confirm the high symmetry and stability of this structure, with bond lengths consistent with strong electrostatic interactions between the ions.[36]The hexahydrate form, SrCl₂·6H₂O, crystallizes in the trigonal system with space group P3₂₁ (No. 152). The structure features infinite chains of [Sr(H₂O)₆]²⁺ octahedra, where each Sr²⁺ ion is coordinated solely to six oxygen atoms from water molecules in a regular octahedral geometry, with isolated Cl⁻ anions residing between these cationic chains to maintain charge balance. Lattice parameters are a = 7.9596 Å and c = 4.1243 Å. Neutrondiffraction studies reveal precise hydrogen positions and a network of hydrogen bonds that stabilize the framework, underscoring the role of water molecules in the coordination environment and overall ionic assembly.
Vapor phase structure
In the vapor phase, strontium chloride exists primarily as discrete SrCl₂ molecules that exhibit a quasilinear geometry, characterized by a thermal average Cl–Sr–Cl bond angle of 142.4° ± 4.0° and an Sr–Cl bond length of 2.625 ± 0.010 Å (r_g structure).[37] This configuration arises from a shallow bending potential energy surface, with quantum-chemical calculations at the MP2 level indicating a small barrier of approximately 0.1 kcal mol⁻¹ at the linear geometry, leading to vibrational averaging that results in the observed non-linearity.[37] Although valence shell electron pair repulsion (VSEPR) theory predicts a linear arrangement for this AX₂-type molecule, the quasilinear nature reflects polarization effects and the weak ionic bonding in the gas phase, where the structure is more molecular than in the solid state fluorite lattice.[37]The molecular parameters were experimentally determined through high-temperature gas-phase electron diffraction, complemented by ab initio computations that yield an equilibrium Sr–Cl bond length of 2.605 ± 0.006 Å, in close agreement with the thermal average.[37] Supporting evidence comes from gas-phase infrared spectroscopy, which has identified vibrational modes consistent with the bent structure, including asymmetric and symmetric stretching frequencies that align with the computed force constants.[37] Matrix-isolated infrared studies further corroborate these findings, though they may show slight perturbations due to interactions with the host matrix.[37]At lower vapor pressures or temperatures, SrCl₂ tends to dimerize, forming (SrCl₂)₂ species with two bridging chloride ligands in a planar, rhombic arrangement around each strontium center, though monomers predominate under typical high-temperature conditions.[38] This gas-phase molecular behavior is particularly relevant in high-temperature processes, such as evaporation during production or combustion in flames, where the quasilinear monomers influence spectroscopic signatures and reactivity.[37]
Applications
Pyrotechnics
Strontium chloride has been employed in pyrotechnics since the 19th century to produce vibrant red colors in fireworks, particularly for red stars, due to the introduction of stronger oxidizers like potassium chlorate that enabled more intense flame emissions.[39] This compound contributes to the crimson hues observed in displays by facilitating the formation of excited strontium species during combustion.[39]The red color arises from electronic transitions in Sr²⁺ ions, primarily through the molecular emission of strontium monochloride (SrCl), which produces a bright crimsonred at wavelengths of 635 nm, 660 nm, and 672 nm.[40] In contrast, other strontium salts like the nitrate lead to emissions from SrO at around 606 nm (orange-red) or SrOH in the 630–700 nm range (less saturated red), making SrCl superior for deeper, more vivid red tones.[40] The overall redemission spans 606–686 nm, enhanced by the presence of chlorine, which suppresses unwanted orange contributions from hydroxide or oxide species.[40]In pyrotechnic formulations, anhydrous strontium chloride is preferred for its stability and is mixed with oxidizers such as potassium nitrate (KNO₃) and fuels like shellac or chlorinated organics to achieve a balanced oxygen supply and chlorine donation for optimal SrCl formation.[39] This approach yields a cleaner burn compared to strontium nitrate alone, as the chloride reduces hygroscopic issues and minimizes extraneous emissions, resulting in higher color purity without the water absorption problems associated with nitrates.[39][40]Specific applications of strontium compounds include road flares for emergency signaling, tracer bullets in militaryammunition to mark trajectories with a visible red trail, and marine distress signals for high-visibility alerts at sea.[41]
Dental care
Strontium chloride has been utilized in oral health products primarily as a desensitizing agent to alleviate dentin hypersensitivity, a common condition causing sharp pain in teeth exposed to thermal, tactile, or chemical stimuli. This application leverages the compound's ability to interact with tooth surfaces, providing relief for individuals with sensitive teeth resulting from enamel erosion or gingival recession.[42]The mechanism of action involves strontium ions from strontium chloride reacting with carbonate ions present in saliva to form strontium carbonate (SrCO₃) precipitates. These precipitates deposit within the dentinal tubules, occluding them and blocking the flow of fluids that trigger pain according to the hydrodynamic theory of dentinsensitivity, thereby reducing discomfort from hot, cold, or other irritants.[43][44]The incorporation of strontium chloride into dental formulations originated from research in the mid-20th century, with patents filed in the late 1950s and early 1960s for its desensitizing and potential anti-cavity properties, marking an early innovation in over-the-counter oral care.[45]Commercially, strontium chloride was introduced in toothpastes such as Sensodyne Original in the 1960s, where it was formulated at approximately 10% strontium chloride hexahydrate to effectively target sensitivity.[46][47]In terms of efficacy, clinical studies have demonstrated that regular use of strontium chloride-containing dentifrices results in significant reductions in dentinhypersensitivity, with reported decreases in sensitivity scores ranging from 40% to 60% after consistent application over several weeks; the U.S. Food and Drug Administration has approved such formulations as desensitizing agents.[47][48]Unlike potassium nitrate-based desensitizers, which work by depolarizing nerve endings to temporarily block pain signals, strontium chloride primarily achieves relief through physical occlusion of dentinal tubules rather than neural modulation.[50][51]The hexahydrate form of strontium chloride is commonly employed in dental gels and aqueous toothpaste pastes due to its stability and solubility in saliva, facilitating effective delivery to tooth surfaces without compromising product consistency.[47]
Biological research
Strontium chloride (SrCl₂) is widely employed in reproductive biology to induce parthenogenetic activation of mammalian oocytes, a process that mimics the calcium signaling triggered by natural fertilization. At concentrations of 10 mM, SrCl₂ effectively activates cumulus-free mouseoocytes, achieving activation rates of up to 91% after exposure durations of 0.5 to 5 hours.[52] In human and bovine models, similar concentrations (10-20 mM) have been used successfully to promote oocyte activation in in vitro fertilization (IVF) and nuclear transfer experiments.[53][54]The mechanism involves Sr²⁺ ions entering the oocyte through plasma membrane channels, such as TRPV3, where they substitute for Ca²⁺ due to their similar ionic properties and trigger repetitive calcium oscillations via inositol 1,4,5-trisphosphate (InsP₃) receptor-mediated release from intracellular stores.[55][56] These oscillations activate downstream pathways essential for meiotic resumption, cortical granule exocytosis, and pronuclear formation, facilitating embryo production in assisted reproduction protocols.[57]In practice, oocytes are typically incubated in SrCl₂ medium for 4-6 hours post-IVF or intracytoplasmic sperm injection (ICSI), often combined with 5 μg/mL cytochalasin B to inhibit polar body extrusion and enhance diploidy.[58][59] Activation success rates approximate 70% across mouse, human, and bovine systems, with improved fertilization outcomes in cases of ICSI failure.[60][61] Compared to calcium ionophores like A23187, which induce transient Ca²⁺ rises, SrCl₂ produces longer-lasting oscillations that more closely resemble physiological sperm-induced patterns, potentially supporting better embryonic development in animal models.[62][63]This application of SrCl₂ originated in the 1990s as part of advancements in ICSI and parthenogenetic techniques, with early studies demonstrating its efficacy in mouse oocytes for nuclear transfer and IVF research.[52][64]
Industrial uses
Strontium chloride serves as a key precursor in the industrial synthesis of various strontium salts through precipitation reactions. For instance, it is reacted with sodium chromate to produce strontium chromate (SrCrO₄), a yellowpigment employed as a corrosion inhibitor in protective coatings for metals like aluminum.[65] Similarly, precipitation with sodium carbonate yields strontium carbonate (SrCO₃), which is widely used in the ceramics industry to formulate glazes and ferrites due to its fluxing properties and ability to enhance material durability:\text{SrCl}_2 + \text{Na}_2\text{CO}_3 \rightarrow \text{SrCO}_3 + 2\text{NaCl}[66] In the oil and gas sector, strontium chloride is converted to strontium sulfate (SrSO₄) via reaction with sodium sulfate, serving as a weighting agent in drilling fluids to control formation pressure and prevent blowouts.[67]Another significant industrial application involves strontium chloride's role in ammonia storage systems for selective catalytic reduction (SCR) of nitrogen oxides (NOx) in diesel engine exhaust. It forms reversible ammine complexes, such as [Sr(NH₃)₈]Cl₂, which absorb and release ammonia efficiently under varying temperatures, enabling compact solid-state storage that improves NOx conversion efficiency, particularly at low exhaust temperatures below 200°C.[68] These complexes outperform traditional urea-based systems by reducing ammonia slip and enhancing system reliability in heavy-duty vehicles.[69]In agronomy, strontium chloride combined with citric acid (typically 0.02 M SrCl₂ and 0.05 M citric acid) acts as an extractant in soil testing to assess nutrient availability. This method effectively solubilizes exchangeable forms of phosphorus, potassium, and other micronutrients like copper, providing a reliable indicator of soil fertility and guiding fertilizer applications without interfering with calcium or magnesium extraction.[70] Studies have validated its efficacy across diverse soil types, including calcareous soils, where it correlates well with plant uptake.[71]Strontium chloride finds minor applications in electron tubes as a component in vacuum systems and getters, and in optical experiments for spectroscopy due to its distinct emission lines. Additionally, it plays a limited role in the electrolytic production of strontium metal, where molten strontium chloride mixed with potassium chloride undergoes electrolysis in a graphitecrucible, yielding pure strontium at the cathode while chlorine gas evolves at the anode.[72][73] Market analyses indicate that strontium chloride constitutes a notable portion of strontium compound intermediates, supporting these downstream processes.[32]As of 2025, strontium chloride is being investigated for thermochemical energy storage applications, utilizing its hydration and dehydration cycles to store and release heat efficiently in low-temperature systems. Recent studies have examined its structural and morphological transformations during cycling, highlighting its potential for sustainable energy solutions.[74][75]
Safety and Environmental Impact
Health hazards
Strontium chloride is an irritant to the eyes and respiratory tract upon acute exposure. Contact with the eyes can cause serious damage and severe irritation requiring immediate medical attention. Skin exposure does not cause significant irritation based on standardized tests, though general irritant classifications apply. Inhalation of dust or fumes irritates the respiratory tract, leading to coughing, shortness of breath, and mucosal inflammation.[76][77]Ingestion of strontium chloride exhibits low acute oral toxicity, with an LD50 greater than 2,000 mg/kg in rats, indicating it is not highly poisonous in single doses. However, it can cause gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain due to its similarity to calcium in metabolic pathways. Unlike more toxic analogs like barium chloride, strontium chloride does not typically lead to severe systemic effects from incidental ingestion.[77][76][78]Chronic inhalation or ingestion may pose risks, particularly to bone health, as strontium mimics calcium and accumulates in skeletal tissue. Prolonged exposure has been associated with strontium rickets in children, characterized by impaired bone development and growth disturbances, especially in cases of nutritional deficiencies. No evidence links strontium chloride to carcinogenicity; it is not classified as a carcinogen by major regulatory bodies.[78][77]Regulatory classifications identify strontium chloride as an irritant (Xi) under older EU directives, with hazards including eye damage and respiratory irritation. OSHA has not established a specific permissible exposure limit (PEL) for strontium compounds, but general limits for nuisance dust apply at 15 mg/m³ (total) and 5 mg/m³ (respirable) as an 8-hour time-weighted average. Children and pregnant women are vulnerable populations due to strontium's interference with calcium-dependent bonemetabolism and higher absorption rates during growth phases.[76][79][78]
Environmental considerations
Strontium chloride is highly soluble in water, with a solubility of 53.8 g/100 mL at 20°C for the anhydrous form, facilitating rapid dispersion and limiting long-term persistence in aquatic environments. Once released, the compound dissociates into Sr²⁺ ions, which exhibit moderate mobility in soils and sediments due to sorption to clays and metal oxides, but in water bodies, natural dilution occurs effectively in large volumes.[23] The Sr²⁺ ion can bioaccumulate in aquatic organisms, particularly in fish and shellfish, where bioconcentration factors (BCF) relative to water levels can exceed 50,000 in bony tissues in soft, low-calcium waters due to its chemical similarity to calcium.[80]Ecotoxicity of strontium chloride to aquatic life is generally low, with acute toxicity thresholds such as LC50 values exceeding 100 mg/L for fishspecies like striped bass (Morone saxatilis) over 96 hours.[81] Chronic effects are minimal at environmentally relevant concentrations, and the compound poses no risk of ozone depletion or contribution to global warming potential, as it is neither volatile nor a greenhouse gas.[23]Primary sources of strontium release into the environment from anthropogenic activities include industrial effluents during strontium chloride production and runoff from mining operations extracting celestine (SrSO4), the principal ore for strontium compounds.[82] These releases can elevate local strontium levels in surface waters and soils near production sites.Under the European Union's REACH regulation, strontium chloride (CAS 10476-85-4) is registered, requiring assessment of environmental risks, though it is not classified as a persistent, bioaccumulative, or toxic (PBT) substance.[83] In the United States, the Environmental Protection Agency (EPA) does not list stable strontium as a priority pollutant under the Clean Water Act, but it monitors radioactive isotopes in drinking water with a maximum contaminant level (MCL) equivalent to 4 mrem/year whole-body or organ dose, primarily targeting strontium-90 rather than stable forms. Stable strontium lacks a federal MCL for non-radioactive exposure.Remediation efforts for strontium chloride releases are rarely necessary, as its high solubility promotes natural attenuation through dilution in rivers, lakes, and oceans, where background concentrations (e.g., 0.001–13.6 mg/L in freshwater) often mask low-level inputs.[23]In the long term, elevated strontium from repeated industrial or mining inputs can contribute to increased soil levels, potentially interfering with calcium uptake in crops and affecting agricultural productivity if concentrations exceed natural baselines (e.g., >240 mg/kg globally).[84][85]