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Terumo

Terumo Corporation is a leading Japanese multinational medical device company founded on September 17, 1921, as the Red Line Thermometer Corporation by a group of physicians and scientists, including Dr. Shibasaburo Kitasato, with the initial aim of producing accurate clinical thermometers to meet domestic needs in Japan.^[1] Renamed Terumo Corporation in 1974, it has grown into a global enterprise headquartered in Tokyo, employing over 30,000 people and operating in more than 160 countries and regions, with a mission to "Contribute to Society through Healthcare" by developing innovative medical technologies.^[2] Listed on the Tokyo Stock Exchange (TSE: 4543) since 1982, the company reported net sales of 1,036.2 billion yen for the fiscal year ending March 2025, reflecting its significant scale in the healthcare sector.^[2] Terumo's product portfolio originated with Japan's first clinical thermometer in 1922 and expanded rapidly into disposable medical devices, including the country's inaugural disposable syringe in 1963 and blood bag in 1969, addressing critical needs for safe and efficient patient care.^[1] Over the decades, it pioneered advancements such as the world's first microporous hollow-fiber membrane oxygenator in 1982 for cardiac surgery, and later entered neurovascular interventions through the 2006 acquisition of MicroVention Inc., as well as regenerative medicine with the 2015 approval of an autologous skeletal myoblast sheet for heart treatment in Japan.^[1] The company's business is organized into three main segments: the Cardiac and Vascular Company, which focuses on minimally invasive treatments for heart, lung, brain, and vascular diseases through products like catheters, oxygenators, heart-lung machines, surgical grafts, and stent grafts; the Medical Care Solutions Company, emphasizing infection control and personalized medicine solutions for aging populations and chronic conditions; and the Blood and Cell Technologies Company, providing tools, software, and services for blood collection, processing, transfusions, and cell therapies to support hospitals, blood centers, and researchers worldwide.^[3] Terumo's global expansion began with U.S. and European affiliates in 1971, followed by key acquisitions such as Terumo Cardiovascular Systems in 1999 and CaridianBCT in 2011, enabling it to offer over 50,000 products and services tailored to diverse medical settings from hospitals to home care.^[1] Celebrating its 100th anniversary in 2021, Terumo continues to prioritize sustainability, corporate governance, and innovation, including responses to global health challenges like COVID-19 through enhanced supply chains and product development, while committing to the UN Global Compact principles on human rights, labor, environment, and anti-corruption.^[1]^[4]

History

Founding and early years

Terumo Corporation traces its origins to September 17, 1921, when it was established as the Red Line Thermometer Corporation in Tokyo, Japan, by a group of physicians and scientists led by Dr. Shibasaburo Kitasato.^[1] The founding was prompted by acute shortages of clinical thermometers, as imports from major suppliers in Germany, the United Kingdom, and the United States were disrupted by the ongoing effects of World War I, leaving Japanese medical facilities in dire need of reliable domestic alternatives.^[5] Kitasato, a renowned bacteriologist and founder of the Japan Medical Association, spearheaded the initiative to manufacture high-precision mercury-in-glass thermometers locally, aiming to support public health amid the global crisis.^[1] In February 1922, the company introduced its inaugural product, Jintan Taionkei, recognized as Japan's first domestically produced clinical thermometer.^[1] This mercury-filled glass device, developed in collaboration with the Jintan pharmaceutical company, addressed the immediate demand for accurate temperature measurement tools in hospitals and clinics, establishing Terumo's early reputation in precision medical instrumentation.^[5] The product's success enabled the fledgling enterprise to expand production capabilities, focusing initially on glass-based thermometers to meet growing domestic needs. By the mid-1930s, the company had solidified its position in thermometer manufacturing and underwent a significant rebranding. In November 1936, it changed its name to Jintan Thermometer Corporation, reflecting its partnership with Jintan Honpo, which had sponsored a naming contest for the 1922 thermometer and provided marketing support.^[1] Throughout the 1930s and 1940s, operations centered on refining glass thermometer technology, with production emphasizing durability and accuracy for clinical use, though the era's economic pressures limited diversification into broader medical tools.^[5] World War II brought severe challenges, including widespread resource shortages of raw materials like mercury and glass, yet Terumo's workforce persisted in producing thermometers and essential medical devices to support wartime healthcare efforts.^[5] Following Japan's defeat in 1945, the company navigated post-war turmoil, including economic devastation and supply chain disruptions, by recommitting to peacetime medical production and gradually restoring output of clinical thermometers to aid national recovery.^[5] This period of resilience laid the groundwork for Terumo's sustained focus on domestic innovation in medical devices.

Key innovations and milestones

In the post-war era, Terumo marked a significant advancement in medical device safety with the introduction of Japan's first disposable syringe in January 1963. This innovation shifted away from reusable glass syringes, substantially reducing the risk of cross-contamination and infections in clinical settings, thereby revolutionizing infection control practices in healthcare.^[6] Building on this momentum, Terumo launched Japan's first plastic blood bag in July 1969, incorporating a preservative solution to extend blood shelf life. The product facilitated safer and more efficient blood transfusions by minimizing exposure to air and contaminants compared to traditional glass bottles, which had higher breakage risks and limited storage capabilities.^[6] In 1977, the company entered the field of artificial organs by developing and launching Japan's first hollow-fiber dialyzer, a key component in hemodialysis that improved filtration efficiency and patient comfort during renal treatments.^[5] A pivotal achievement came in April 1982 when Terumo introduced the Capiox II, the world's first microporous hollow-fiber membrane oxygenator designed for cardiac surgery. This device enhanced gas exchange during cardiopulmonary bypass procedures, leading to better oxygenation, reduced blood trauma, and improved surgical outcomes for patients undergoing open-heart operations.^[6] That same year, in June 1982, Terumo achieved financial maturity by listing on the Second Section of the Tokyo Stock Exchange, which provided greater access to capital and signaled its growing stature in the medical technology sector.^[6] By September 1985, Terumo expanded into vascular intervention with the launch of Japan's first angiographic catheter system, enabling more precise diagnostic imaging and therapeutic interventions for cardiovascular diseases, solidifying its leadership in cardiovascular technologies.^[5]

International expansion and modern developments

Terumo's international expansion began in the early 1970s with the establishment of its first overseas subsidiaries: Terumo Medical Corporation in the United States in April 1971 and Terumo Europe N.V. in Belgium in May 1971.^[1] This was followed by further European growth, including Terumo Italia S.r.l. and Laboratoires Terumo France S.A. in 1973. During the 1980s and 1990s, the company extended its presence into Asia with subsidiaries such as Terumo Medical Products (Hangzhou) Co., Ltd. in China in 1995, Changchun Terumo Medical Products Co., Ltd. in China in 1996, and a joint venture, Terumo Penpol Pvt. Ltd., in India in 1999, alongside production facilities in the Philippines starting in 2000.^[1] These moves solidified Terumo's global footprint, supported by its designation for listing in the First Section of the Tokyo Stock Exchange in 1985, which enhanced its access to capital for further international operations.^[1] By the 2000s, Terumo had achieved full global operational scale, with subsidiaries and manufacturing sites across the Americas, Europe, Asia, and beyond. Overseas sales became the dominant portion of its revenue, accounting for approximately 69% of total revenue in fiscal year 2019 (ended March 2020), reflecting robust growth in international markets despite challenges like the COVID-19 pandemic.^[7] This expansion transformed Terumo from a Japan-centric manufacturer into a multinational leader in medical technology. In 2021, Terumo celebrated its 100th anniversary, commemorating its evolution from a producer of clinical thermometers founded in 1921 to a pioneer in advanced therapies, including regenerative medicine products like the autologous skeletal myoblast sheet launched in 2016 for treating severe heart failure.^[5] The milestone underscored the company's commitment to addressing evolving healthcare needs over a century.^[8] Post-2010, Terumo shifted toward enhanced sustainability initiatives, emphasizing eco-friendly manufacturing practices such as energy reduction to combat global warming and achieving zero emissions across operations.^[9] These efforts included resource-efficient production methods that minimized environmental impact while supporting human welfare.^[10] Additionally, the company advanced diversity and inclusion, promoting varied backgrounds among directors and global associates to foster inclusive governance and innovation.^[11] A key recent milestone was the completion of a clinical study in February 2021 for a novel drug-device combination product in Japan, utilizing Terumo's automated injection device for G-Lasta, a medication to reduce febrile neutropenia in cancer patients undergoing chemotherapy; this paved the way for regulatory approval and eventual market introduction.^[12] In December 2022, Terumo launched the G-Lasta Subcutaneous Injection with BodyPod automated device in Japan, enabling self-administration and reducing hospital visits for patients.^[13] In August 2025, Terumo announced its acquisition of OrganOx Limited, marking entry into the organ transplantation sector with innovative preservation technology to address unmet needs in transplant medicine.^[14]

Corporate structure

Leadership and governance

Terumo Corporation's leadership is headed by President and Chief Executive Officer Hikaru Samejima, who assumed the role in April 2024 and guides the company's global strategic initiatives in medical technology innovation and market expansion.^[15] Samejima, appointed as a director at the 109th Annual General Meeting of Shareholders on June 26, 2024, brings extensive experience in operations and international business to steer Terumo toward sustainable growth in healthcare solutions.^[16] The Board of Directors comprises 10 members, selected for their collective expertise in management, finance, accounting, legal affairs, healthcare research, diversity, equity and inclusion (DE&I), and environmental, social, and governance (ESG) matters.^[16] This includes five outside directors, all independent and accounting for 50% of the board, to ensure balanced oversight and external perspectives.^[16] Diversity is a key focus, with two female directors, Mari Kogiso and Keiko Hayashi, and non-Japanese representation reaching 33.3% among group executive officers; overall, female managers in the Terumo Group constitute 30.8%, reflecting ongoing efforts to enhance inclusivity.^[16] Terumo's governance structure operates as a company with an Audit and Supervisory Committee, fully adhering to the Japanese Corporate Governance Code to promote transparency, accountability, and shareholder interests.^[16] ESG integration has been a priority since 2015, marked by annual board effectiveness evaluations, the publication of sustainability reports, and the establishment of a Sustainability Committee in April 2023.^[16] The company's Sustainability Policy, revised in December 2021, incorporates the Task Force on Climate-related Financial Disclosures (TCFD) framework since fiscal year 2020, embedding environmental and social considerations into core decision-making processes.^[16] Historically, Terumo's foundational leadership traces back to its 1921 establishment by medical scientists led by Dr. Shibasaburo Kitasato, who is honored as an honorary founder for initiating thermometer production.^[5] Post-war presidents were instrumental in driving product diversification, transitioning the company from clinical thermometers to innovative disposable medical devices and broader healthcare technologies during the mid-20th century.^[1]

Headquarters and subsidiaries

Terumo Corporation's global headquarters is located at 2-44-1 Hatagaya, Shibuya-ku, Tokyo 151-0072, Japan, where the company was founded on September 17, 1921, and has maintained primary research and development as well as manufacturing operations in the Hatagaya district since its inception.^[2] The headquarters oversees the company's core functions, including strategic planning and coordination of its international network, while supporting ongoing innovation in medical technologies.^[2] Key subsidiaries include Terumo Cardiovascular Systems Corporation, based in Ann Arbor, Michigan, USA, which was established following Terumo's acquisition of 3M's cardiovascular division in 1999 and focuses on cardiac surgery products.^[1] MicroVention, Inc., located in Aliso Viejo, California, USA, specializes in neurovascular devices and was acquired by Terumo in 2006, later rebranding as Terumo Neuro in 2024 to reflect expanded offerings.^[17] Terumo BCT, Inc., headquartered in Lakewood, Colorado, USA, handles blood and cell technologies and originated from the 2011 acquisition of CaridianBCT, providing solutions for transfusion and cell therapy applications.^[1] These subsidiaries operate as independent entities aligned with Terumo's business segments, particularly for specialized technologies like cell therapy.^[3] Regionally, Terumo's European operations are centered at Terumo Europe N.V. in Leuven, Belgium, serving as the hub for sales, distribution, and regulatory activities across the EMEA region.^[18] In Asia, manufacturing facilities include sites in Hangzhou and Weihai, China, through subsidiaries like Terumo Medical Products (Hangzhou) Co., Ltd. and Wego Terumo (Weihai) Medical Products Co., Ltd., while the Asia-Pacific headquarters is in Singapore via Terumo Asia Holdings Pte. Ltd.^[19] As of 2025, Terumo employs 30,689 people worldwide and provides products and services in more than 160 countries, supported by this extensive network of subsidiaries and facilities.^[2]

Business segments

Cardiac and Vascular Business

Terumo's Cardiac and Vascular Business develops and sells interventional cardiology tools and related devices for treating heart and blood vessel conditions, forming a core part of the company's portfolio in minimally invasive therapies. This segment includes divisions such as Terumo Interventional Systems (TIS) for coronary and peripheral interventions, Terumo Cardiovascular for surgical support systems, and others focused on neurovascular and aortic solutions. These operations emphasize devices that enable precise access, treatment, and monitoring during procedures like percutaneous coronary intervention (PCI) and cardiopulmonary bypass, contributing significantly to global cardiovascular care.^[3] Central to this business are products like the Ultimaster™ sirolimus-eluting coronary stent, a thin-strut, biodegradable-polymer device launched in Europe in 2014 and subsequently in other markets, designed to minimize restenosis through controlled drug release and has been evaluated in clinical trials involving over 50,000 patients. Complementary tools include coronary guidewires and microcatheters for navigating lesions, as well as peripheral vascular catheters for treating blockages in non-coronary vessels. For cardiac surgery, the CAPIOX® series of oxygenators, such as the CAPIOX RX and FX Advance models, provide efficient gas exchange and low-prime volumes during cardiopulmonary bypass, supporting procedures that replace heart and lung functions temporarily. These innovations build on Terumo's advancements in drug-eluting stents since 2010, including bioresorbable polymers introduced earlier to enhance long-term vessel health.^[20]^[21]^[22] Terumo maintains a leadership position in Japan's interventional cardiology market, particularly in radial access and PCI devices, while expanding in the U.S. and Europe through regulatory approvals and clinical evidence. The company's TIS division, a key driver, has grown via innovations like the Ultimaster platform and benefits from the 2006 acquisition of MicroVention for neurovascular enhancements. In the fiscal year ended March 31, 2025, the broader Cardiac and Vascular segment reported ¥624.4 billion in revenue, with TIS contributing ¥480.6 billion—approximately 46% of Terumo's total ¥1,036.2 billion—with growth propelled by strong performance in the Americas and Europe.^[23]^[6]

Medical Products Business

Terumo's Medical Products Business encompasses a range of everyday medical consumables designed for general hospital use, including disposable syringes, IV infusion sets, blood pressure monitors, and wound care dressings. These products support routine clinical procedures such as fluid administration, medication delivery, vital sign monitoring, and post-operative care, emphasizing reliability, ease of use, and infection prevention. In the fiscal year ended March 31, 2025, this segment accounted for approximately 20% of the company's total revenue, underscoring its role as a stable revenue driver amid Terumo's broader portfolio.^[24] The evolution of Terumo's offerings in this area traces back to 1963, when the company introduced Japan's first plastic disposable syringe, transitioning from traditional glass models to enhance sterility and disposability while reducing infection risks associated with reuse. Key products include the SurGuard safety hypodermic syringes and needles, which feature mechanisms to prevent needlestick injuries, and IV infusion sets like the Surshield series with integrated safety shields. Blood pressure monitors, such as the ELEMANO series, provide accurate auscultatory measurements comparable to mercury sphygmomanometers, while wound care solutions incorporate anti-adhesion sprays to minimize post-surgical complications. These innovations prioritize patient safety and clinician efficiency, with features like DEHP-free materials and clear barrel designs for precise dosing.^[25]^[26]^[27] Terumo maintains a dominant market position in the Asia-Pacific region for these consumables, benefiting from strong local demand in healthcare settings across Japan, China, and Southeast Asia. The company exports to over 160 countries worldwide, ensuring broad accessibility through established distribution networks. Safety enhancements, such as needleless connectors in products like the Surplug Micro Clear, reduce bacterial contamination risks during IV therapy, aligning with global standards for infection control. Manufacturing occurs at key facilities in Japan (e.g., Kofu Plant), China (Terumo Medical Products Hangzhou), and the Philippines (Terumo Philippines Corporation), supporting an annual production volume exceeding 1 billion syringes to meet global needs.^[2]^[28]^[29]

Blood and Cell Technologies Business

Terumo's Blood and Cell Technologies Business focuses on solutions for blood collection, processing, and cell therapy, enabling safer transfusions and advancing regenerative medicine worldwide. This segment, operated primarily through the subsidiary Terumo BCT, provides automated systems and consumables that support blood centers, therapeutic apheresis, and the manufacturing of cell-based therapies. In fiscal year 2024 (ended March 31, 2025), it generated ¥200.3 billion in revenue, accounting for approximately 19% of Terumo's total ¥1,036.2 billion, with growth driven by demand in plasma collection and cell therapy applications.^[24]^[23] Key products include blood bags, introduced by Terumo in 1969 as Japan's first such innovation for safe blood preservation and transfusion, which remain a cornerstone for whole blood and component storage globally.^[1] Apheresis systems, such as the Spectra Optia platform, facilitate the separation and collection of blood components like platelets, plasma, and stem cells, with applications in therapeutic procedures for conditions including sickle cell disease.^[30] Additionally, the Quantum Cell Expansion System, launched in 2018, is a functionally closed, automated bioreactor for expanding adherent cells like mesenchymal stem cells and T cells, supporting scalable production for clinical trials and therapies.^[31] Innovations in this business emphasize safety and efficiency, including the Mirasol Pathogen Reduction Technology, which uses riboflavin and UV light to inactivate pathogens in platelets, plasma, and whole blood without compromising component quality, thereby reducing transfusion-transmitted infection risks. Automated cell therapy platforms like Quantum Flex and Finia further enable closed, scalable manufacturing for personalized medicine, integrating cell expansion, transduction, and fill-finish processes to streamline gene and cell therapy production.^[32] These advancements build on Terumo's long-standing expertise in blood handling, with the 1969 blood bag milestone marking an early contribution to transfusion safety.^[1] Terumo BCT holds market leadership as a global standard in transfusion sets and blood processing consumables, particularly in the U.S., where it dominates therapeutic apheresis and plasma collection markets through integrated hardware, disposables, and software solutions.^[33] The business operates in over 150 countries, with strong U.S. presence via facilities in Colorado and expansions supporting growing demands for cell and gene therapies.^[34]

Acquisitions and growth

Major acquisitions

In 1999, Terumo Corporation acquired the cardiovascular division of 3M Company, establishing Terumo Cardiovascular Systems Corporation in the United States. This move integrated 3M's technologies, including oxygenators and perfusion systems used in cardiopulmonary bypass procedures, significantly enhancing Terumo's capabilities in cardiac surgery equipment and enabling a full range of products for open-heart operations.^[35]^[1] In 2006, Terumo purchased MicroVention, Inc., a California-based developer of endovascular devices, marking its entry into the neurovascular market. The acquisition bolstered Terumo's portfolio with innovative aneurysm treatment systems, such as detachable coils and balloon-assisted devices, which have since expanded to over 30 products for neuroendovascular interventions.^[36]^[17] Terumo expanded its blood management offerings in 2011 through the $2.63 billion acquisition of CaridianBCT from Gambro AB, which was rebranded as Terumo BCT. This deal added advanced apheresis and cell therapy technologies, positioning Terumo as a global leader in blood component collection and processing systems.^[37]^[38] More recently, in 2019, Terumo acquired Aortica Corporation, a U.S.-based firm specializing in personalized vascular therapy software. The purchase supported Terumo's vascular graft business by incorporating Aortica's AortaFit platform, which automates case planning for fenestrated endovascular aneurysm repair (FEVAR), advancing customized treatment options for aortic diseases.^[39]^[40] In 2021, Terumo signed a definitive agreement to acquire all assets of Health Outcomes Sciences, Inc., a provider of predictive analytics for cardiovascular care. This integration of the ePRISM platform expanded Terumo's digital health capabilities, enabling data-driven personalization of patient outcomes in interventional procedures.^[41]^[42] In 2025, Terumo completed the acquisition of WuXi Biologics' drug product plant in Leverkusen, Germany, for 150 million euros (approximately $167 million USD as of May 2025). Announced in May 2025 and finalized on October 1, 2025, the purchase expands Terumo's contract development and manufacturing organization (CDMO) capabilities in pharmaceutical solutions, adding a cGMP-compliant facility with about 150 employees to support sterile injectable drug production in Europe.^[43]^[44] Also in 2025, Terumo completed the $1.5 billion acquisition of OrganOx Limited, a UK-based innovator in organ preservation devices. The deal, announced in August 2025 and closed on October 30, 2025, introduced normothermic machine perfusion technology for livers and kidneys, entering the organ transplantation sector to improve graft viability and address unmet needs in transplant medicine.^[45]^[46]

Strategic partnerships and collaborations

Terumo has pursued strategic partnerships to enhance technology development, expand market access, and foster innovation in medical devices without pursuing full acquisitions. These alliances often involve shared intellectual property, co-development, and localized production to address global healthcare needs. In China, Terumo established Terumo Medical Products (Hangzhou) Co., Ltd. in 1995 to support local manufacturing of medical products, facilitating efficient supply chains in the Asia-Pacific region.^[6] Additionally, in 2012, Terumo formed a strategic business alliance with Shandong Weigao Group Medical Polymer Company Limited for peritoneal dialysis solutions, enabling joint production and distribution to meet regional demands for renal care.^[47] This partnership later evolved into a joint venture with WEGO Blood Purification Products Co., Ltd., which received approval for peritoneal dialysis solutions in 2018, strengthening Terumo's presence in China's growing medical market.^[48] Terumo collaborates with academic institutions on regenerative medicine research, including participation in cell sheet technology projects led by Professor Teruo Okano at Tokyo Women's Medical University since the mid-2010s. This work contributed to the 2015 approval and 2016 launch of HeartSheet, an autologous skeletal myoblast sheet for treating severe heart failure.^[49] Terumo also partnered with Osaka University and Dai Nippon Printing (DNP) to establish a joint research department focused on scalable manufacturing of regenerative therapies for cardiac conditions.^[50] Through its Alliance Division, Terumo maintains ongoing partnerships with pharmaceutical companies to co-develop drug-device combination products, integrating pharmaceuticals with delivery systems for improved patient outcomes. These collaborations emphasize safety and efficacy in areas like injectable therapies, with Terumo providing expertise in device design and manufacturing.^[51]^[52] On the global stage, Terumo supported World Health Organization (WHO) efforts during the COVID-19 pandemic from 2020 to 2022 by donating over USD 4 million in cash and products to aid relief initiatives, including blood safety and supply chain stability. This included contributions to WHO-partnered programs for tracking the virus and ensuring access to critical care.^[53] Terumo's blood and cell technologies also aligned with international standards for pathogen reduction, such as the Mirasol system, which demonstrated effectiveness against SARS-CoV-2 in plasma and platelets.^[54] These partnerships have accelerated Terumo's market entry into emerging regions like China and India, while bolstering its innovation pipeline through external expertise and shared R&D. For instance, alliances in Asia have enabled localized production, reducing costs and improving responsiveness to regional healthcare needs.^[55] Overall, such collaborations contribute to Terumo's medium-term growth strategy by integrating diverse technologies and expanding therapeutic offerings.^[56]

Research and development

Innovation focus areas

Terumo allocates approximately 7.5% of its annual revenue to research and development, equating to about ¥69.1 billion (roughly $490 million USD) in fiscal year 2023, with investments rising to around ¥74.2 billion in fiscal year 2024, primarily directed toward advancing minimally invasive technologies and personalized medicine solutions.^[57]^[58] This strategic emphasis supports the company's goal of enhancing patient outcomes through innovative medical interventions that reduce procedural risks and tailor treatments to individual needs.^[59] Key innovation priorities include regenerative therapies, such as stem cell expansion technologies developed since around 2015, exemplified by the Quantum Cell Expansion System, which enables automated, closed-system cultivation of cells like mesenchymal stem cells for therapeutic applications.^[31]^[60] Terumo also invests in AI-integrated diagnostics, including partnerships for AI-driven fractional flow reserve (FFR) tools like AutoCathFFR, which improve diagnostic accuracy and efficiency in cardiovascular procedures by analyzing angiographic images in real-time.^[61] Additionally, efforts focus on sustainable materials for medical devices, leveraging AI to accelerate the discovery of environmentally friendly, biocompatible polymers that minimize ecological impact while ensuring device performance and safety.^[62]^[63] The company's central R&D hub is located at the Shonan Center in Kanagawa Prefecture, Japan, which coordinates global corporate research activities across four specialized divisions focused on long-term technological development.^[64] In the United States, Terumo maintains specialized labs, including the newly established D-TECT center in California for broad innovation collaboration and the Terumo Cardiovascular Systems facility in Ann Arbor, Michigan, dedicated to cardiovascular simulations and device prototyping.^[65]^[66] These facilities enable targeted advancements in hemodynamic modeling and procedural simulations to optimize device efficacy.^[67] A notable milestone in Terumo's innovation efforts is its robust intellectual property portfolio, comprising approximately 8,500 patents worldwide as of March 2025, with ongoing filings emphasizing biocompatibility testing and adherence to patient safety standards such as ISO 10993 protocols.^[68] This focus ensures that new materials and devices meet rigorous regulatory requirements for minimizing adverse reactions and enhancing clinical reliability.^[69]

Key patents and technologies

Terumo has secured numerous patents central to its innovations in medical devices, particularly in vascular, cardiac, and cell therapy applications. One notable example is the WEB Aneurysm Embolization System, acquired through the 2016 purchase of Sequent Medical, which features patented technology for intrasaccular treatment of brain aneurysms. The core patent, US9198670B2, describes filamentary devices forming a self-expanding resilient permeable shell for treating cerebral aneurysms, enabling endovascular embolization of ruptured and unruptured intracranial aneurysms without traditional coil packing.^[70] This innovation, developed by Sequent and now under Terumo's MicroVention subsidiary, received FDA Premarket Approval in 2018 as the first intrasaccular flow disruptor.^[71] In cardiac surgery support, Terumo's hollow-fiber membrane oxygenator technology traces back to a foundational 1982 patent, US4374802A, which outlines a device using hollow fibers for efficient gas exchange between blood and oxygen during cardiopulmonary bypass.^[72] This microporous design, the world's first of its kind, has evolved through ongoing iterations, including the Capiox series, to minimize inflammatory responses by reducing hemodilution and platelet activation—key factors in post-surgical complications. Clinical studies on models like the Capiox FX05 demonstrate lower levels of inflammatory markers such as interleukin-6 and C-reactive protein compared to earlier oxygenators.^[73] These advancements continue to enhance safety and efficiency in procedures like coronary artery bypass grafting. The Quantum Cell Expansion System, patented in 2018 among other filings, automates the culture and expansion of adherent cells, including stem cells for regenerative therapies such as CAR-T cell treatments. Key intellectual property includes US10577585B2, covering methods for cell expansion in a bioreactor with controlled fluid dynamics to achieve high yields while maintaining cell viability. Launched by Terumo BCT, the system uses hollow-fiber bioreactors to scale production from small volumes to therapeutic doses, reducing manual labor and contamination risks in GMP environments. Over 150 related patents protect its components globally.^[74] The 2025 acquisition of OrganOx introduced advanced intellectual property in organ preservation, notably the metra system for normothermic perfusion, which extends liver and kidney viability beyond traditional cold storage by maintaining physiological conditions during transport. This technology, protected by multiple patents including those for dynamic organ support platforms, improves transplant success rates by reducing ischemia-reperfusion injury. As of March 2025, Terumo holds approximately 8,500 patents worldwide, reflecting its extensive IP portfolio across subsidiaries.^[68]^[75] Terumo also pursues technology transfer through licensing agreements, including deals for blood bag additives that enhance preservation and safety in transfusion medicine, generating ongoing royalty income from global partners.^[68]

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Terumo (TSE:4543) is a global leader in medical technology and has been committed to Contributing to Society through Healthcare for 100 years.
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May 14, 2025 · Overseas, revenue increased by 15.2% year on year due to expansion in the Terumo Interventional Systems division (formerly, TIS division), ...<|separator|>
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[PDF] Financial Results for the Fiscal Year Ended March 31, 2025 (FY2024)
May 14, 2025 · C&V︓ Significant growth in global sales and profit, driven by US. 15%. 8%. 12%. (8%). 25%. (14%). （100M JPY）. ( ) FX Neutral. (C&V: Cardiac and ...
[30]
Spectra Optia Apheresis System - Terumo BCT
An advanced therapeutic apheresis, cell processing, and cell collection platform. The Spectra Optia™ Apheresis System is an industry-leading therapeutic ...
[31]
Quantum Flex Cell Expansion System - Terumo BCT
The Quantum Flex system from Terumo Blood and Cell Technologies is a holistic, connected solution designed to meet your multiple cell culture bioreactor needs.Missing: 2018 | Show results with:2018
[32]
Cell Therapy Technologies - Terumo BCT
Developers can use our Quantum Flex™ Cell Expansion System to expand multiple cell types, including mesenchymal stem cells (MSCs), T cells, fibroblasts ...
[33]
[PDF] Value of the Blood and Cell Technologies Business in the Terumo ...
May 12, 2022 · Markets. Presence globally and in emerging markets. Market Leadr in US. No US giants present. Hardware (centrifugation) + Consumable + Software.<|control11|><|separator|>
[34]
[PDF] Blood and Cell Technologies Company - Terumo Global
At Terumo Blood and Cell Technologies, we provide compelling and accessible innovations that unlock the power of blood and cells globally. We shape patient ...<|control11|><|separator|>
[35]
COMPANY NEWS; TERUMO SAYS IT WILL BUY 3M'S ...
Apr 16, 1999 · The acquisition of 3M's cardiovascular business, which has annual sales of $100 million, will enable Terumo to supply all the equipment needed ...
[36]
Terumo Announces Acquisition of MicroVention
Feb 28, 2006 · A majority of MicroVention's shareholders have agreed to vote in favor of the transaction and it is expected to close by March 31, 2006 subject ...
[37]
Terumo to buy medical device firm for $2.6 billion - Reuters
Mar 7, 2011 · Terumo Corp <4543.T> said it would buy US medical device company CaridianBCT from a Swedish firm for about $2.6 billion.
[38]
Terumo Corporation Completes Acquisition of CaridianBCT, Inc.
Terumo announced today the completion of the previously announced pending acquisition of CaridianBCT Holding Corp. (Head Office: Colorado, the United States)
[39]
Terumo Acquires Aortica Corporation
Nov 20, 2019 · Terumo acquired Aortica to support its vascular graft business, develop a FEVAR system, and advance personalized therapy using Aortica's ...
[40]
Terumo Acquires Aortica Corporation to Further Bolster Its Vascular ...
Nov 19, 2019 · Terumo Corporation announced the acquisition of Aortica Corporation, which developed the AortaFit automated case planning software to match fenestrations.
[41]
Terumo Signs a Definitive Agreement to Acquire All Assets of Health ...
Feb 23, 2021 · "The acquisition of Health Outcomes Sciences and the ePRISM® platform expands Terumo's presence in the digital healthcare arena and represents a ...
[42]
Terumo reaches agreement to acquire predictive analytics specialist ...
Feb 24, 2021 · Terumo Corporation has signed a definitive agreement to acquire all assets of Health Outcomes Sciences, a specialist in predictive analytics and clinical ...
[43]
Terumo to acquire OrganOx Limited, a leading innovator in organ ...
Aug 24, 2025 · Terumo to acquire OrganOx Limited, a leading innovator in organ preservation devices, marking strategic entry into the organ transplantation- ...
[44]
Terumo completes acquisition of OrganOx
Oct 30, 2025 · TOKYO, JAPAN – October 30, 2025 – Terumo Corporation (TSE: 4543) today announced that it has completed the acquisition of all outstanding shares ...
[45]
Terumo Announces Strategic Business Alliance with Weigao in ...
Mar 19, 2012 · Terumo is pleased to announce that a strategic business alliance has been formed with Shandong Weigao Group Medical Polymer Company Limited.Missing: 1996 | Show results with:1996
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Terumo's Affiliate in China to Receive an Approval for PD solution
Aug 6, 2018 · The affiliated company was established as a joint venture of WEGO Blood Purification Products Co., Ltd and Terumo. With the conclusion of ...Missing: 1996 | Show results with:1996
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Terumo Receives Approval for the Manufacturer and Sale of its ...
Sep 18, 2015 · Terumo has also participated in a research project on regenerative medicine using cell sheets. It is led by Professor Teruo Okano of Tokyo ...Missing: collaboration | Show results with:collaboration
[48]
Osaka University, Terumo and DNP Establish Joint Research ...
The department aims to develop regenerative medicine-driven cardio therapiesby conducting research on low cost, effective manufacture and quality ...Missing: Tokyo 2015<|separator|>
[49]
A Novel Drug-Device Combination Product Using Terumo's ...
Feb 7, 2021 · A Novel Drug-Device Combination Product Using Terumo's Automated Injection Device Completes Clinical Study in Japan ... 7, 2021 /PRNewswire/ -- ...
[50]
Pharmaceutical Solutions - Terumo Global
Business Partnerships with Pharmaceutical Companies. We partner with pharmaceutical companies to develop and manufacture drug-device combination products.Missing: 2015 | Show results with:2015
[51]
Terumo's Response to COVID-19
Terumo Key Policies Regarding COVID-19. 1.To protect the health and safety of all Terumo Associates with utmost priority. 2.To maintain a stable supply of ...Missing: 2020-2022 | Show results with:2020-2022
[52]
Terumo BCT's Mirasol Reduces the Virus Causing COVID-19 Below ...
Apr 23, 2020 · The results showed that Mirasol is effective against SARS-CoV-2, the virus causing COVID-19, when high virus levels are present in human plasma and platelets.
[53]
Japan's Terumo Plays Catch-up in China's Growing Medical Market
Terumo Corp.'s recent announcement that it was forming a joint venture with a subsidiary of Shandong Weigao Group Medical Polymer Co. suggests that Japan's ...Missing: 1996 | Show results with:1996
[54]
[PDF] Terumo Report 2023
We contribute to society by providing valued products and services in the healthcare market and by responding to the needs of patients and healthcare ...Missing: II | Show results with:II
[55]
[PDF] Financial Results for the Fiscal Year Ended March 31, 2025 (FY2024)
May 14, 2025 · Factors affecting to actual results include, but are not limited to, changes in economic conditions surrounding Terumo, fluctuations of foreign ...
[56]
Terumo | Medtech Big 100 largest medical device companies
Revenue ($USD) : $6,561,297,821. Revenue (foreign currencies) : JP¥921,863,000,000. R&D spend : $491,529,899. Employees : 30,591. CEO : Hikaru Samejima.
[57]
#09 Delivering Efficiency and Quality to Cell Therapy Manufacturing
Terumo Blood and Cell Technologies provides products and services that automate and improve efficiency throughout the cell therapy cycle.Missing: platforms | Show results with:platforms
[58]
Terumo and MedHub-AI partner to market AI-based FFR in Japan
Jun 17, 2025 · AutocathFFRTM's novel end-to-end AI approach enhances diagnostic efficiency while enabling continuous performance improvements, facilitating ...Missing: integrated | Show results with:integrated
[59]
Terumo uses AI to speed up material discovery for medical devices
Aug 29, 2025 · At Terumo, we are leveraging #AI and advanced chemical information search tools to reshape material development and accelerate #innovation.Missing: regenerative sustainable
[60]
Our Commitment to EHS - Terumo Medical Corporation
- Developing environmentally friendly products and associated production processes. Develop and implement processes to identify, assess, monitor, review ...
[61]
Research and Development | Basic Information | Technology | Terumo
In April 2022, a new organizational structure for corporate R&D started. We have established four divisions in the Shonan Center, which is the R&D base in Japan ...
[62]
Terumo opens new R&D center in the U.S. to strengthen global ...
Mar 31, 2025 · The new center will facilitate collaboration with local medical institutions, academia and startups to reinforce Terumo's global Corporate R&D capabilities.Missing: regenerative therapies AI diagnostics<|separator|>
[63]
About Us : Terumo Cardiovascular
In 1999, Terumo ... Terumo Cardiovascular Systems entered into an exclusive distribution agreement with Pall Corporation for cardiovascular filters.
[64]
06 Terumo Bay Area Innovation Lab A place to create new value
To meet next-generation healthcare needs, Terumo establishes research and development sites in the optimal region for each product.
[65]
Intellectual Property | Basic Information | Technology - Terumo Global
Terumo views intellectual property as vital, holding ~8,500 patents, and has received awards for medical device innovations.
[66]
[PDF] Records processed under FOIA # 2015-4436; Released by CDRH ...
Nov 18, 2016 · Biocompatibility. E. CONCLUSION. The biocompatibility reports, on file at Terumo, represent all of the blood/body contacting materials present ...
[67]
US9198670B2 - Filamentary devices for treatment of vascular defects
Methods for treatment of a cerebral aneurysm are described. Embodiments may include a self-expanding resilient permeable shell having a radially constrained ...
[68]
[PDF] united states of america - FDA
Sep 27, 2018 · EndoBridge Aneurysm Embolization System from Sequent Medical, a wholly owned subsidiary of MicroVention. Today's FDA presentation will be ...
[69]
US4374802A - Oxygenator - Google Patents
A hollow fiber type oxygenator comprising a housing having an inlet port and an outlet port for oxygen and an inlet port and an outlet port for blood, ...
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Randomized Trial of the Terumo Capiox® FX05 Oxygenator ... - NIH
The purpose of this clinical trial was to evaluate the effect of the Terumo Capiox® FX05 oxygenator with integrated arterial filter during cardiopulmonary ...
[71]
[PDF] Quantum™ and Quantum Flex™ Cell Expansion System 8/1/2024
Aug 1, 2024 · European Patent Convention. 2625264. European Patent Convention ... Quantum™ and Quantum Flex™ Cell Expansion System. Country. Pat. No ...
[72]
OrganOx Completes Acquisition by Terumo Corporation to Advance ...
Oct 30, 2025 · As first announced on August 25, 2025, the acquisition combines OrganOx's pioneering organ perfusion technology with Terumo's global scale and ...