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Titanium tetrachloride

Titanium tetrachloride is an with the TiCl₄ and a molecular weight of 189.68 g/mol. It appears as a colorless to pale yellow fuming liquid with a pungent , characterized by a of 136.4 °C, a of -24.1 °C, and a of 1.726 g/cm³ at 20 °C. Chemically, it is highly reactive and corrosive, undergoing rapid exothermic in the presence of moisture or water to form (HCl) and titanium oxides or orthotitanic acids, which produces dense white fumes and significant heat. Produced commercially by the chlorination of (TiO₂) or titanium ores such as or at high temperatures in the presence of a like carbon, titanium tetrachloride serves as a key intermediate in the Kroll process for extracting titanium metal. Its primary applications include the manufacture of titanium dioxide pigments for paints, coatings, and plastics; the production of titanium metal for and biomedical uses; and as a component in Ziegler-Natta catalysts for reactions in the production of polyolefins. Additionally, it is utilized in the creation of iridescent glass, artificial pearls, and military smoke screens due to its fuming properties. Due to its extreme corrosivity and , titanium tetrachloride poses significant hazards, causing severe burns to and eyes upon contact, as well as respiratory damage and if inhaled. It is classified as a hazardous substance requiring strict handling protocols, including storage in conditions and use of protective equipment.

Physical and Chemical Properties

Physical Properties

Titanium tetrachloride is a colorless at , though crude samples may appear yellow or reddish-brown due to impurities such as or iron chlorides. It exhibits a pungent, acidic and is highly volatile, readily forming dense white fumes upon exposure to moist air owing to partial . The compound has a of 189.68 g/mol, a of -24.1 °C, and a of 136.4 °C at standard pressure. Its is 1.726 g/cm³ at 20 °C, making it significantly denser than . The is 10 mmHg at 20 °C, contributing to its fuming behavior, while the vapor density relative to air is 6.55. Titanium tetrachloride is miscible with many organic solvents, including , , and , but it reacts violently with , precluding measurements in aqueous media.

Structural Features

Titanium tetrachloride, TiCl₄, features a with the central Ti(IV) ion bonded to four ligands, consistent with the VSEPR model for AX₄ species and the d⁰ electronic configuration of in the +4 . The experimentally determined Ti–Cl is 2.170 Å, reflecting the covalent character of these bonds formed between the electropositive and electronegative atoms. In terms of bonding, the titanium center utilizes sp³ hybrid orbitals derived from its 4s and 3p atomic orbitals to accommodate the tetrahedral arrangement, forming four equivalent σ-bonds with the chloride ligands' 3p orbitals. The high +4 results in an empty 3d subshell (d⁰), precluding any significant d-orbital participation in the ground-state bonding and emphasizing the ionic-covalent hybrid nature without backbonding. Spectroscopic techniques confirm this structure: the spectrum of gaseous TiCl₄ exhibits a characteristic Ti–Cl stretching frequency (ν₃ mode) at 498.5 cm⁻¹, indicative of the symmetric tetrahedral environment and the strength of the metal-ligand bonds. similarly shows active modes consistent with Td symmetry, including a strong ν₁ symmetric stretch at 389 cm⁻¹, further validating the monomeric tetrahedral form without bridging interactions. Compared to other group 4 tetrachlorides, TiCl₄ maintains a strictly monomeric tetrahedral in , , and gas phases, whereas ZrCl₄ and HfCl₄ adopt polymeric structures in the state featuring bridging chlorides that increase coordination numbers beyond four. This monomeric nature of TiCl₄ contributes to its greater relative to the more associated ZrCl₄ and HfCl₄, influencing their phase behaviors and reactivity profiles.

Synthesis and Production

Industrial Production

Titanium tetrachloride is produced industrially primarily through the high-temperature chlorination of titanium-bearing feedstocks such as (TiO₂) or (FeTiO₃), mixed with carbon (typically ) and exposed to gas. This process occurs in fluidized-bed or shaft chlorinators at temperatures ranging from 900 to 1000 °C, where the titanium oxide is converted to volatile TiCl₄ gas. The core reaction for chlorination is given by: \text{TiO}_2 + 2\text{Cl}_2 + 2\text{C} \rightarrow \text{TiCl}_4 + 2\text{CO} For ilmenite, the process also generates iron(III) chloride (FeCl₃) as a byproduct, which is volatile under reaction conditions and subsequently separated. To achieve higher purity and efficiency, ilmenite is often pre-processed into titanium slag, which contains 85–95% TiO₂ and reduced iron content, serving as a preferred feedstock in modern plants. This slag is produced via electric arc smelting of ilmenite, minimizing impurities that could complicate downstream steps. Byproducts such as FeCl₃ are condensed at lower temperatures (around 300 °C) and collected for reuse or disposal, while unreacted carbon and other solids form a waste residue. The crude TiCl₄ vapor from chlorination contains impurities like vanadium oxychloride (VOCl₃) and (SiCl₄), which are removed through under an inert atmosphere (e.g., or ) to prevent . TiCl₄, with a of 136 °C, is separated from lower-boiling impurities such as SiCl₄ (57 °C) and VOCl₃ (127 °C) in multi-stage columns, yielding high-purity product (>99.9%) suitable for further applications. Global production of titanium tetrachloride reached approximately 5.2 million metric tons in 2022 (as of 2023 report), with estimates for 2025 around 5.5–6 million tons (projected as of 2023), driven largely by demand for pigments. The market value is projected to grow from about USD 11.3 billion in 2025 to USD 17.1 billion by 2035 (as of 2023).

Laboratory Synthesis

In laboratory settings, titanium tetrachloride (TiCl₄) is typically synthesized on a small scale through direct chlorination of metal or titanium oxides using gas (Cl₂) at elevated temperatures ranging from 500–800 °C. The reaction with titanium metal proceeds as follows: \ce{Ti + 2 Cl2 -> TiCl4} This method allows for rapid reaction under , though higher temperatures are employed when starting from oxides like TiO₂ to overcome the stability of the oxide lattice, often with carbon as a : \ce{TiO2 + 2 Cl2 + 2 C -> TiCl4 + 2 CO} These approaches enable controlled production in quartz or silica apparatus, with gas flow rates of 50–150 cc/min to ensure complete chlorination. The crude product from either method is purified via vacuum distillation, often in specialized apparatus like a Podbielniak still under high vacuum (to exclude air and moisture), yielding TiCl₄ with purities exceeding 99.99 mole percent after fractional reflux and freezing-pumping cycles. These techniques trace back to early 20th-century laboratory methods, initially developed without inert atmospheres, but now routinely adapted for use in gloveboxes to rigorously exclude moisture and prevent hydrolysis during synthesis and storage. High-purity TiCl₄ prepared this way is critical for sensitive applications, such as organometallic synthesis.

Applications

Titanium Metal Production

Titanium tetrachloride (TiCl₄) serves as the primary precursor in the industrial production of titanium metal, most notably through the Kroll process, which accounts for the vast majority of global output. In this pyrometallurgical method, developed by Wilhelm J. Kroll in the 1940s and commercialized in the late 1940s, TiCl₄ is reduced by molten magnesium to yield titanium sponge, a porous form of the metal that is subsequently processed into ingots, alloys, and finished products. The process operates under an inert argon atmosphere to prevent oxidation, with the core reaction occurring at temperatures of 800–900 °C:
\ce{TiCl4 + 2Mg -> Ti + 2MgCl2}
This reduction produces titanium metal along with magnesium chloride as a byproduct, which can be electrolyzed to recover magnesium for reuse.
The Kroll process unfolds in several key steps within a sealed . TiCl₄, typically sourced from the chlorination of ores like or , is first vaporized and introduced into the retort containing molten magnesium. The proceeds over 4–10 days, forming solid titanium sponge that adheres to the retort walls while liquid MgCl₂ collects at the bottom. Once complete, the retort is cooled, and the titanium sponge is mechanically removed using tools like jackhammers, then crushed and leached to eliminate residual magnesium and chloride impurities. Final purification involves at around 1000 °C under low pressure (0.1–1 ) to volatilize and remove MgCl₂ and excess magnesium, yielding high-purity sponge with oxygen content below 0.2%. Reactors typically produce 1–10 tons per batch, enabling scalable industrial operation. Globally, the Kroll process generates approximately 330,000 metric tons of titanium sponge annually as of 2023, primarily in , , , and , supporting applications in , medical implants, and where titanium's high strength-to-weight ratio and corrosion resistance are critical. An alternative, the Hunter process developed in 1910, reduces TiCl₄ with sodium instead of magnesium at similar temperatures but has been largely supplanted by the Kroll method due to higher costs and lower scalability. The Kroll approach's advantages over direct reduction of titanium ores include superior purity levels (often >99.5% titanium), which minimize inclusions and enhance mechanical properties essential for high-performance components, while avoiding the energy-intensive and inefficient carbothermic reductions that produce contaminated metal.

Titanium Dioxide Production

The chloride process represents the primary industrial method for producing (TiO₂) pigment from titanium tetrachloride (TiCl₄), involving the vapor-phase oxidation of TiCl₄ with oxygen or air. In this process, purified TiCl₄ vapor is introduced into an oxidation reactor where it reacts with oxygen at temperatures ranging from 900 to 1400 °C, typically in a or flame reactor, to form solid TiO₂ particles and gas according to the equation: \ce{TiCl4 + O2 -> TiO2 + 2Cl2} The chlorine gas is recovered and recycled back to the chlorination stage of TiCl₄ production, enhancing process efficiency. Following oxidation, the hot TiO₂ particles are rapidly cooled to prevent agglomeration and ensure desired particle morphology. Impurities such as residual chlorides or metallic contaminants are removed through gas-phase chlorination or calcination, often with the addition of aluminum chloride to promote the rutile crystal structure, which is preferred for its superior opacity and durability in pigments. Particle size is then controlled via classification and surface treatment to optimize dispersibility and performance in end-use applications. This route accounts for approximately 90% of global TiCl₄ consumption and yields high-purity rutile-grade TiO₂, which is widely used in paints, coatings, and plastics due to its excellent light-scattering properties. Compared to the sulfate process, the chloride process is more energy-efficient, produces fewer solid wastes, and benefits from closed-loop recovery, resulting in a lower overall environmental impact.

Other Uses

Titanium tetrachloride has been employed historically in the generation of smoke screens, notably during , where it was released from aircraft to form a dense obscuring upon reaction with atmospheric moisture, yielding fine particles and that effectively scatter light. This application extended to military obscurants and smoke-producing pyrotechnic compositions, where controlled produces persistent smoke for tactical concealment. Due to its production of toxic , leading to acute effects such as corneal damage and chronic conditions like , these uses have been largely discontinued. In , titanium tetrachloride acts as a key Lewis acid component in Ziegler-Natta systems, facilitating the stereospecific of olefins to produce high-value polyolefins like and . These catalysts, typically supported on magnesium dichloride with alkylaluminum cocatalysts, enable industrial-scale production with high efficiency and control over polymer microstructure. Titanium tetrachloride also sees minor specialized applications, including surface treatment of for enhanced and as a volatile precursor in processes for fabricating thin titanium or nitride films in devices. Its reactivity allows precise deposition at low temperatures, critical for advanced . Market projections indicate rising demand for high-purity titanium tetrachloride in as of 2025, driven by its role in etching and layer formation, with the electronic-grade segment expected to contribute to overall market growth from USD 11.3 billion in 2025 to USD 17.1 billion by 2035 at a 4.2% CAGR.

Chemical Reactions

Hydrolysis and Alcoholysis

Titanium tetrachloride reacts violently with in a highly exothermic process, yielding hydrate (TiO₂·nH₂O) and as the primary products. The simplified overall reaction is given by the equation: \ce{TiCl4 + 2 H2O -> TiO2 + 4 HCl} although the actual pathway is multistep and involves the formation of transient species. This reaction proceeds rapidly even upon exposure to atmospheric moisture, generating dense white fumes consisting of an of TiO₂ particles and HCl gas. The mechanism of hydrolysis initiates with the nucleophilic attack of on the center, leading to stepwise ligand exchange where ions are progressively substituted by aqua (H₂O) or hydroxo (OH⁻) groups. Intermediates include aquo complexes such as [TiCl₄(H₂O)] and [TiCl₃(OH)(H₂O)], followed by the formation of oxychlorides like TiOCl₂ and TiCl₂(OH)₂ through and dehydrochlorination steps. These ultimately condense to form the hydrated precipitate, with the process influenced by , temperature, and concentration. In alcoholysis, titanium tetrachloride undergoes substitution with alcohols to produce titanium(IV) alkoxides and HCl. The general reaction is: \ce{TiCl4 + 4 ROH -> Ti(OR)4 + 4 HCl} where R represents an , such as methyl or ethyl; this process mirrors but yields soluble precursors commonly employed in sol-gel for materials. The reaction is typically conducted under anhydrous conditions to avoid competing , often with added to neutralize the HCl byproduct and facilitate isolation. Related reactions occur with , where titanium tetrachloride first forms adducts such as TiCl₄·5NH₃, followed by leading to amido and imido complexes that can evolve into species under heating, commonly used in of films. With primary amines, analogous reactions yield terminal or bridging imido complexes, highlighting the compound's reactivity toward protic nucleophiles.

Complex Formation

Titanium tetrachloride exhibits strong acidity due to its tetrahedral geometry and the availability of empty d orbitals on the central Ti(IV) , enabling it to form coordination complexes with donor ligands such as ethers, amines, and phosphines. These adducts typically octahedral coordination around titanium, achieved by the addition of two monodentate ligands to the original four ligands. Representative examples include the bis-tetrahydrofuran TiCl₄·2THF and the bis-diethyl ether TiCl₄·2Et₂O, both displaying octahedral with the oxygen atoms of the occupying axial positions. The bonding in these species involves dative interactions, wherein lone pairs from the donor atoms are donated to the empty d orbitals, resulting in weakened bonds and moderate stability characterized by measurable dissociation in solution. Adducts with amines, such as those formed with or methyl-substituted pyridines (e.g., TiCl₄·py), demonstrate similar octahedral structures with coordination, while tertiary complexes like TiCl₄·2PMe₂Ph exhibit dynamic equilibria in solution as evidenced by NMR spectroscopy. Spectroscopic confirmation of formation includes shifts in absorption bands; for instance, the C-O stretching frequency in ligands decreases by approximately 50-100 cm⁻¹ upon coordination, reflecting partial double-bond character donation to , while analogous shifts occur in P-C stretches for adducts. These coordination complexes enhance the solubility of titanium tetrachloride in non-aqueous organic media, facilitating its handling and use in reaction environments without immediate .

Chemistry

Titanium tetrachloride, TiCl₄, features titanium in its +4 , the highest stable for the , and thus primarily participates in reactions within its chemistry. The standard for the Ti(IV)/Ti(III) couple in aqueous media, often represented as TiO²⁺ + 2H⁺ + e⁻ → Ti³⁺ + H₂O, is approximately +0.1 versus the (SHE), indicating moderate oxidizing ability under acidic conditions. In non-aqueous media, such as ionic liquids or molten salts, reductions to Ti(III) occur at more negative potentials, typically requiring applied voltages beyond -1 versus Ag/Ag⁺, due to solvent effects and lack of . A common reduction reaction involves metallic reductants like zinc to form titanium(III) chloride, TiCl₃, as shown in the balanced equation: $2 \text{TiCl}_4 + \text{Zn} \rightarrow 2 \text{TiCl}_3 + \text{ZnCl}_2 This process is typically conducted in anhydrous conditions or acidic solutions to control the reduction to the +3 state and avoid further reduction. Other metals, such as aluminum, can also achieve this one-electron reduction, yielding violet TiCl₃ solutions useful for analytical purposes. Oxidation of TiCl₄ is inherently limited, as the +4 oxidation state represents the maximum for titanium under standard conditions, precluding further electron loss without decomposition or formation of higher oxides under extreme oxidizing environments. However, TiCl₄ can act as an oxidant in certain electron-transfer processes, such as oxidative additions in coordination chemistry where it facilitates activation, though these are more relevant to its Lewis acidity than pure changes. In , the Ti(IV)/Ti(III) couple derived from TiCl₄ has garnered interest for applications, particularly in aqueous flow batteries, where its near-neutral potential (≈0.1 V vs SHE) and high in acidic electrolytes enable low-cost, safe systems with energy densities up to 20–30 Wh/L. As of 2025, ongoing research explores TiCl₄-based precursors for electrode modifications in flow batteries and lithium-ion systems, enhancing and through TiO₂ coatings or hybrid electrolytes.

Organometallic Applications

Titanium tetrachloride serves as a key precursor for synthesizing organotitanium compounds containing Ti-C bonds, particularly dialkyltitanium dichlorides of the general formula R₂TiCl₂. These are typically prepared by treating TiCl₄ with two equivalents of an organometallic reagent, such as a (RMgX) or organolithium compound (RLi), in an inert solvent under conditions. For instance, the reaction with methylmagnesium bromide or yields dimethyltitanium dichloride (Me₂TiCl₂), which is isolated as a volatile, air-sensitive . Similar procedures apply to other alkyl or aryl substituents, like dibenzyltitanium dichloride (Bn₂TiCl₂), formed from benzylmagnesium chloride, though these compounds often exhibit limited thermal stability due to β-hydride elimination pathways. In Ziegler-Natta catalysis, TiCl₄ plays a central role in activating early sites for olefin by forming heterogeneous catalysts when supported on magnesium dichloride (MgCl₂). The TiCl₄ adsorbs onto the MgCl₂ surface, creating active centers that, upon with organoaluminum cocatalysts like triethylaluminum (AlEt₃), generate Ti(III) or Ti(IV) species capable of coordinating and inserting olefins such as or into growing polymer chains. This activation process enhances and productivity, as evidenced by the high molecular weight polyolefins produced industrially. TiCl₄ also enables the preparation of metallocene derivatives, including titanocene dichloride (Cp₂TiCl₂), a foundational compound in organotitanium chemistry. Treatment of TiCl₄ with two equivalents of (NaCp) in yields Cp₂TiCl₂ as a red crystalline solid, which is stable in air but hydrolyzes upon prolonged exposure. This metallocene serves as the precursor for , formed by reaction with trimethylaluminum (AlMe₃) in to produce a chloromethylene-bridged Ti-Al complex (Cp₂Ti(μ-CH₂)(μ-Cl)AlMe₂). is thermally stable at low temperatures but decomposes above 0°C, releasing the active titanocene methylidene (Cp₂Ti=CH₂) species used in methylenation reactions; its structure features a nearly square-planar Ti-CH₂-Al-Cl core confirmed by . Organotitanium compounds derived from TiCl₄ are characterized spectroscopically to confirm Ti-C bond formation and assess stability. Proton NMR spectra typically show upfield shifts for alkyl protons attached to titanium (δ ≈ 0–1 ppm for methyl groups), with coupling patterns indicating equivalence in symmetric species like Me₂TiCl₂. reveals characteristic Ti-C stretching vibrations around 500–600 cm⁻¹, while ¹³C NMR provides evidence of carbon-titanium bonding through deshielded signals (δ ≈ 100–150 ppm for methyl carbons). These techniques, often complemented by multinuclear NMR (e.g., ⁴⁷/⁴⁹Ti), distinguish monomeric from oligomeric structures and monitor pathways.

Organic Synthesis Reagent

Titanium tetrachloride (TiCl₄) acts as a potent Lewis acid in , coordinating to oxygen or other heteroatoms to activate substrates for nucleophilic attack, thereby facilitating key carbon-carbon and carbon-heteroatom bond formations without involving titanium-carbon bonds. Its high oxophilicity and ability to form transient complexes make it particularly effective for promoting reactions like cycloadditions, condensations, and electrophilic substitutions under mild conditions. In Diels-Alder reactions, TiCl₄ coordinates to the carbonyl oxygen of α,β-unsaturated carbonyl dienophiles, polarizing the and significantly accelerating the while favoring stereochemistry. Computational studies show that TiCl₄ reduces the activation barrier by up to 20 kcal/mol compared to uncatalyzed reactions, with experimental examples like the [4+2] of and proceeding at -78 °C to give the in 90% yield and >95:5 : selectivity. Similarly, TiCl₄ promotes regioselective Diels-Alder reactions of quinones with alkyl-substituted dienes, enhancing yields to 80-95% at low temperatures. For aldol condensations, TiCl₄ is widely employed in the Mukaiyama aldol reaction, where it activates toward nucleophiles via carbonyl coordination, typically yielding β-hydroxy carbonyl products with high diastereoselectivity. The reaction proceeds through an open , often favoring anti diastereomers; for instance, the addition of a from propanal to with TiCl₄ at -78 °C affords the anti-aldol in 92% yield and 96:4 anti:syn ratio. With chelating aldehydes like α-alkoxy carbonyls, syn selectivity predominates, as seen in the reaction of a methyl ketone-derived with an α-benzyloxy , delivering the syn product in 88% yield and >20:1 syn:anti dr. TiCl₄ also catalyzes Friedel-Crafts acylations and alkylations by generating acylium ions from acid chlorides or activating alkylating agents, enabling efficient . In the acylation of with , TiCl₄ provides in 85% yield, outperforming traditional AlCl₃ in cases sensitive to over-acylation due to its milder Lewis acidity. For alkylations, TiCl₄ promotes the reaction of with to give the ortho/para-substituted product in 78% yield with 60:40 o:p ratio. Recent variants use TiCl₄ for ortho-selective acylation of with aroyl chlorides, yielding 2-acylphenols in 70-95% yields. The conversion of s to chlorohydrins exemplifies TiCl₄'s role in ring-opening, where it coordinates to the oxygen, directing chloride delivery to the less hindered carbon. Treatment of with TiCl₄ in at 0 °C yields the anti-chlorohydrin in 95% yield with complete for the benzylic chloride. For trisubstituted s like that from , TiCl₄ in CH₂Cl₂ provides the chlorohydrin exclusively at the terminal position in 90% yield, preserving . In contemporary asymmetric synthesis, TiCl₄ paired with chiral s enables enantioselective variants of these transformations, drawing from 2020s literature on ligand design. For example, TiCl₄ with a chiral BINOL-derived phosphoramide catalyzes the Mukaiyama aldol between silyl ethers and aldehydes, achieving up to 98% and 95% yield in anti-selective additions. Chiral titanium complexes with ligands promote asymmetric Diels-Alder reactions of quinones, delivering cycloadducts with 90-95% . These systems highlight TiCl₄'s tunability for stereocontrol in complex molecule synthesis.

Safety and Environmental Aspects

Toxicity and Health Effects

Titanium tetrachloride is highly corrosive to tissues, causing severe chemical burns to the skin, eyes, and mucous membranes upon contact due to its rapid in the presence of moisture, which releases (HCl) and heat. Skin exposure results in immediate pain, redness, and blistering, potentially leading to deep tissue damage if not treated promptly. Ocular exposure can produce intense irritation, corneal opacities, and in severe cases, permanent vision impairment or blindness. Inhalation of titanium tetrachloride vapors poses significant risks to the , primarily through the formation of HCl and fine (TiO₂) particles during . Acute exposure can cause coughing, , chest tightness, and chemical , with higher concentrations leading to , a potentially life-threatening accumulation of fluid in the lungs that may be delayed in onset. indicate an LC50 of approximately 460 mg/m³ for rats over 4 hours, underscoring its high via inhalation. Oral exposure, though less common due to its reactivity, has an LD50 of 464 mg/kg in rats, but the compound's tendency to hydrolyze limits its relevance to ingestion scenarios. Systemic effects from titanium tetrachloride exposure are largely confined to the , with potential accumulation of titanium compounds in the s following chronic , leading to conditions such as , pleural thickening, and reduced function. There is no evidence of significant toxicity to other organ systems, such as the liver, kidneys, or , in humans. Regarding carcinogenicity, titanium tetrachloride is not classified by the International Agency for Research on Cancer (IARC) or the U.S. Environmental Protection Agency (EPA), with epidemiological studies showing no association with in exposed workers, though some animal studies have reported lung tumors at high doses whose relevance to humans remains unclear. Occupational limits for titanium tetrachloride are established to prevent adverse effects, with the American Industrial Hygiene Association (AIHA) setting a Workplace Environmental Level (WEEL) of 0.5 mg/m³ as a time-weighted average over 8 hours. No NIOSH REL has been established. Symptoms of over include irritation of the eyes, nose, and throat at levels below 1 mg/m³, escalating to severe respiratory distress above 10 mg/m³. The Agency for Toxic Substances and Disease Registry (ATSDR) has derived minimal risk levels (MRLs) of 0.01 mg/m³ for intermediate-duration and 0.0001 mg/m³ for , based on respiratory effects in animal models.

Handling and Storage

Titanium tetrachloride requires storage in sealed, corrosion-resistant containers such as or Teflon-lined vessels to prevent with container materials. These containers must be maintained under a dry inert atmosphere, typically , in a cool, dry, well-ventilated area away from moisture sources, with temperatures kept below 50 °C to reduce and risks. Handling of titanium tetrachloride in or settings demands use of a to contain its fuming vapors, along with including gloves, tightly fitting safety goggles, chemical-resistant protective clothing, and a suitable such as a NIOSH-approved filter type B or . Inert atmosphere techniques, like glove boxes or Schlenk lines, are essential to avoid contact with air or water during transfer and use. For spill response, immediately evacuate non-essential personnel, ensure adequate to disperse vapors, and avoid direct contact or application, which exacerbates fuming. Neutralize the spilled material by applying , slaked , soda ash, or crushed , followed by absorption with an inert material such as or dry ; ventilate the area thoroughly after containment and cleanup. Titanium tetrachloride is regulated by the () as a corrosive (Class 8, subsidiary 6.1) under 1838, packing group I, requiring special packaging and labeling for transport; it is forbidden on passenger and restricted on , with additional requirements for labeling.

Environmental Impact

The production of titanium tetrachloride through the chloride process involves the reaction of titanium ores with chlorine gas, potentially releasing (HCl) and residual chlorine (Cl₂) from off-gases or incomplete reactions if emissions are not controlled via scrubbing systems. These releases can contribute to when HCl undergoes atmospheric deposition, exacerbating soil and water acidification in surrounding ecosystems. In the United States, industrial facilities reported 24,722 pounds of titanium tetrachloride emissions to air in 1993, predominantly from 38 sites involved in titanium processing, highlighting the scale of potential atmospheric impacts prior to enhanced controls. Waste management in titanium tetrachloride production emphasizes within the chloride process, where recovered Cl₂ is reused in chlorination steps, significantly lowering net emissions and compared to the sulfate process. This closed reduces the environmental footprint by minimizing loss and avoiding disposal of byproducts. byproducts, such as (TiO₂) particulates, are generally non-toxic but exhibit persistence in soils and sediments, where they can accumulate without significant degradation. Regulatory frameworks address titanium tetrachloride's environmental risks through classification and monitoring requirements. Under the REACH regulation, it is not classified as hazardous to the aquatic environment, owing to its rapid into less mobile compounds upon release. The U.S. EPA mandates reporting of any releases exceeding 1000 pounds (454 kg) to air or water, with ongoing monitoring of discharges to prevent ecosystem contamination from HCl or particulates. from these releases shows low potential across food chains, as it forms inert oxides that do not readily enter biological tissues. Sustainability trends in titanium tetrachloride-related production as of 2025 focus on transitioning to greener feedstocks, such as recycled titanium scrap and industrial residues, to reduce reliance on virgin ores and curb emissions. Closed-loop processes, including enhanced chlorine recovery and waste minimization, are gaining adoption under EU policies like the , aiming to double recycling rates and lower the carbon footprint of the titanium supply chain.

References

  1. [1]
    Titanium Tetrachloride | TiCl4 | CID 24193 - PubChem
    Titanium tetrachloride is a titanium molecular entity that is titanium which carries 4 chlorine atoms. It has a role as a NMR chemical shift reference compound.
  2. [2]
    [PDF] Titanium Tetrachloride Interim AEGL Document
    tetrachloride is used in the manufacturing of titanium dioxide pigments, titanium metal, artificial ... titanium chloride. Chemical formula. 4. TiCl4.
  3. [3]
    [PDF] Crude TiCl4 purification: a review of the current state of the art and ...
    Aug 17, 2016 · It is a clear colourless liquid in pure form, but crude titanium tetrachloride may be yellow or reddish-brown in appearance. It has low ...
  4. [4]
    [PDF] Toxicological Profile for Titanium Tetrachloride
    3.2 PHYSICAL AND CHEMICAL PROPERTIES. Information regarding the physical and chemical properties of titanium tetrachloride is located in. Table 3-2. Page 86 ...
  5. [5]
    TITANIUM TETRACHLORIDE - CAMEO Chemicals - NOAA
    TITANIUM TETRACHLORIDE ; Specific Gravity: 1.726 (EPA, 1998) - Denser than water; will sink ; Boiling Point: 277.5°F at 760 mmHg (EPA, 1998) ; Molecular Weight: ...
  6. [6]
  7. [7]
    mp-30092: TiCl4 (Monoclinic, P2_1/c, 14) - Materials Project
    Ti⁴⁺ is bonded in a tetrahedral geometry to four Cl¹⁻ atoms. All Ti-Cl bond lengths are 2.18 Å. There are four inequivalent Cl¹⁻ sites. In the first Cl¹ ...
  8. [8]
    Experimental data for TiCl 4 (Titanium tetrachloride)
    Calculated geometries for TiCl4 (Titanium tetrachloride). Experimental Bond Angles (degrees) from cartesians bond angles. atom1, atom2, atom3, angle, atom1 ...
  9. [9]
    Titanium tetrachloride - the NIST WebBook
    Titanium tetrachloride · Formula: Cl4Ti · Molecular weight: 189.679 · IUPAC Standard InChI: InChI=1S/4ClH. · IUPAC Standard InChIKey: XJDNKRIXUMDJCW-UHFFFAOYSA-JMissing: stretching | Show results with:stretching
  10. [10]
    Vibrational modes and structure of liquid and gaseous zirconium ...
    Spectra of solid and molten zirconium chloride show that in the liquid phase ZrCl4 monomers are present in equilibrium with polymer-like (ZrCl4)n species.Missing: TiCl4 | Show results with:TiCl4
  11. [11]
    [PDF] Titanium 2020 - USGS Publications Warehouse
    May 8, 2024 · TiCl4 is oxidized with air or oxygen at about 1,000 degrees Celsius (°C), and the resulting tiO2 is calcined to remove residual chlorine and ...
  12. [12]
    [PDF] Titanium Tetrachloride Production by the Chloride - Regulations.gov
    This document presents the U.S. Environmental Protection Agency's (EPA) factual basis for withdrawing a waste generated in the production of titanium ...Missing: crude | Show results with:crude
  13. [13]
    Preparation of TiCl4 from panzhihua ilmenite concentrate by boiling ...
    At present, TiCl4 is mainly produced from TiO2-rich slag (or rutile) through high-temperature chlorination in the presence of petroleum coke [3]. According to ...
  14. [14]
    Process for purifying titanium tetrachloride - Free Patents Online
    Dec 5, 2002 · Titanium tetrachloride is typically purified by distillation, but this does not effectively remove close-boiling metal chloride impurities to ...
  15. [15]
    (PDF) Purification of titanium tetrachloride from titania slag chlorination
    Aug 9, 2025 · Obtained results showed that the chemical pre‐treatment method exhibited a higher efficiency for TiCl4 purification than the distillation method ...
  16. [16]
    Titanium Tetrachloride Market Size, Share, Growth & Forecast, 2032
    The global Titanium Tetrachloride market was 5200 thousand tonnes in 2022, and is expected to reach 7800 thousand tonnes by 2032, growing at a CAGR of 4.1%.
  17. [17]
    Titanium Tetrachloride (TiCl4) Market | Global Market Analysis Report
    Aug 19, 2025 · The global titanium tetrachloride (TiCl4) market is estimated to be valued at USD 11,345.4 million in 2025. What will be the size of titanium ...
  18. [18]
    [PDF] Heat of formation of titanium tetrachloride
    itanium reacts rapidly with an excess of chlorine nnder atmospheric pressure at about 3000 C to produce gaseous TiCl4•. In this case there is no uncertainty ...
  19. [19]
    [PDF] Preparation of Titanium Tetrachloride : Some Experiments for the ...
    As one of the fundamental experiments on the preparation of titanium tetra- chloride, several chlorinations such as that with and without carbon by chlorine.
  20. [20]
    [PDF] Preparation of titanium tetrachloride of high purity
    The one-to-one mixture is a thick, syrupy yellow mass, which gradually becomes a yellow transparent solution. ... titanium tetrachloride not readily or casil~' ...
  21. [21]
    Research Progress of Titanium Sponge Production: A Review - MDPI
    In 1940, W.J. Kroll from Luxembourg produced titanium sponge by reducing TiCl4 with Mg instead of Ca, and this method was first successfully used commercially ...
  22. [22]
    The Process of Producing Titanium - American Carbon Company
    Sep 22, 2023 · This is achieved through a two-step process involving chlorination and reduction. Chlorination: The prepared ore, whether it is ilmenite or ...
  23. [23]
    [PDF] mcs2024-titanium.pdf - USGS.gov
    China led a global increase in sponge production and capacity. Sponge production in Zaporozhye,. Ukraine, was idled because of the conflict with Russia.
  24. [24]
    Titanium Extraction Metallurgy Developments and Control of ...
    Sodium reduction of TiCl4 known as Hunter's process has also been employed for the industrial production of titanium sponges for about two decades. Subsequently ...
  25. [25]
    Titanium Dioxide - NCBI Bookshelf - NCBI - NIH
    Conversion to titanium dioxide is accomplished by burning titanium tetrachloride with air or oxygen at temperatures of 1200–1370°C.
  26. [26]
    [PDF] Production of titanium and titanium dioxide from ilmenite and related ...
    Feb 23, 2023 · More than 80 percent of the estimated global production of titanium concentrate is obtained from the processing of ilmenite, while 13 percent ...
  27. [27]
    Life cycle assessment comparison of emerging and traditional ...
    Feb 15, 2015 · Titanium dioxide is traditionally produced by two distinct methods: the sulfate process and the chloride process (Gásquez et al., 2014). The ...
  28. [28]
    Watch: Airplane Makes Battleship Disappear With a Smoke Screen
    Oct 5, 2020 · The smoke screen is likely made from titanium tetrachloride, a corrosive liquid that reacts with air moisture. Smoke screens are used to ...
  29. [29]
    Burn Rate Studies of a Titanium-Based Ptrotechnic Smoke ...
    Jan 1, 2013 · Abstract. A pyrotechnic smoke composition producing titanium tetrachloride (TiCl4) as one of the major reaciion products hasj been studied.
  30. [30]
    Adsorption of Titanium Tetrachloride on Magnesium Dichloride ... - NIH
    Magnesium dichloride and titanium tetrachloride are key components in heterogeneous Ziegler–Natta olefin polymerization catalysis.
  31. [31]
    Titanium Tetrachloride (TiCl₄) - Tronox
    ... used in the production of catalysts, pearlescent pigments and titanium metal and the surface treatment of metal and glass. It is also used as a Ti precursor ...Missing: etching | Show results with:etching
  32. [32]
    Atomic Layer Deposition of Titanium Oxide-Based Films for ... - MDPI
    Aug 8, 2023 · Two widely used atomic layer deposition precursors, Tetrakis (dimethylamido) titanium (TDMA-Ti) and titanium tetrachloride (TiCl 4 ), were investigated
  33. [33]
    Titanium Tetrachloride Market Report | Global Forecast From 2025 ...
    The global titanium tetrachloride market size was estimated at USD 10.5 billion in 2023 and is projected to reach USD 16.8 billion by 2032, growing at a CAGR ...Missing: volume | Show results with:volume
  34. [34]
  35. [35]
    Hydrolysis of TiCl4: Initial Steps in the Production of TiO2
    ### Summary of Hydrolysis of TiCl4 from J. Phys. Chem. A (2010), DOI: 10.1021/jp102020h
  36. [36]
    Terminal and Bridging Imido Complexes from Titanium Tetrachloride ...
    Terminal and Bridging Imido Complexes from Titanium Tetrachloride and Primary Amines. Implications for the Chemical Vapor Deposition of Titanium Nitride Films.
  37. [37]
    Stereochemistry of octahedral titanium(IV) complexes. I. Titanium ...
    Stereochemistry of octahedral titanium(IV) complexes. I. Titanium tetrachloride-titanium tetrafluoride-tetrahydrofuran system | Inorganic Chemistry.
  38. [38]
    Reaction of TiCl4 with diethyl ether. Experimental and quantum ...
    Aug 10, 2025 · The TiCl4·2Et2O complex does not pass in the gas phase. Formation of ethoxytrichlorotitanium among reaction products was established by the X- ...
  39. [39]
    Concerning the structures of Lewis base adducts of titanium(IV ... - NIH
    The molecular structue of 3 shown in Fig. 2 ▸ emphasizes the nearly octahedral coordination geometry of the Ti atom. The fluoroalkoxide ligands form a facial ...
  40. [40]
    Lewis acid/base adducts of TiCl4 and methylpyridines - ResearchGate
    By the reaction of 2-methyl-and 2,6-dimethylpyridine the first neutral TiCl4L complexes (L = single bonded ligand) could be synthesized.
  41. [41]
    [PDF] Electrochemical Reduction of Titanium in Nonaqueous Solvents
    Pourbaix (3) gives the standard potentials (Eo) for the stepwise reduction of. Ti in aqueous solutions as follows: EO = 0.100 V. EO = -0.368 V. Ti2+ + 2e- = Ti.<|separator|>
  42. [42]
    How to Reduce Titanium Tetrachloride - 911Metallurgist
    Feb 18, 2021 · Reduction of titanium tetrachloride with Hss is accomplished by adding molten sodium and vaporized titanium tetrachloride simultaneously to an agitated bed of ...
  43. [43]
    Electrochemistry of Titanium Tetrachloride in 1-Butyl-2,3-dimethyl ...
    Aug 9, 2025 · The electrochemistry of titanium tetrachloride has been examined in trialkyl-substituted imidazolium tetrafluoroborate at 65°C. Ti(IV) ...
  44. [44]
    Extended first-principles thermochemistry for the oxidation of ...
    The oxidation of titanium tetrachloride (TiCl4), known as the chloride process [2], [3], is one of two major routes used for the commercial manufacture of ...
  45. [45]
    Halide abstraction from titanium(III) chloride by zinc chloride
    Heterodinuclear titanium/zinc catalysis: synthesis, characterization and activity for CO 2 /epoxide copolymerization and cyclic ester polymerization.
  46. [46]
    Enhanced Electrochemical Performance of Vanadium Redox Flow ...
    Nov 21, 2024 · Firstly, 1.1 mL of titanium tetrachloride (TiCl4) was dissolved in 50 mL of ethanol. After thorough mixing, the solution was poured onto ...
  47. [47]
    Dichlorodimethyltitanium - Reetz - Major Reference Works
    Apr 15, 2001 · Preparative Methods: several methylmetal reagents such as Methyllithium, Methylmagnesium Bromide , Me2Zn, and Trimethylaluminum react ...Missing: dichloride | Show results with:dichloride
  48. [48]
    Organotitanium Compounds. II. Stability of the Titanium—Carbon Bond
    Cite this: J. Am. Chem. Soc. 1953, 75, 16, 3882–3887. Click to copy citation ... Catalytic Enantioselective Alkylation and Arylation of Aldehydes by Using ...Missing: TiCl4 | Show results with:TiCl4
  49. [49]
    Adsorption of Titanium Tetrachloride on Magnesium Dichloride ...
    Aug 24, 2018 · Magnesium dichloride and titanium tetrachloride are key components in heterogeneous Ziegler–Natta olefin polymerization catalysis.
  50. [50]
    The Influence of Ziegler-Natta and Metallocene Catalysts on ...
    Heterogeneous Ziegler-Natta catalysts are composed of titanium tetrachloride ... Ziegler-Natta Catalysts to the Advancement in Olefin Polymerization Processes.
  51. [51]
    A study of titanium and magnesium chloride complexes with dialkyl ...
    A series of dialkyl phthalate complexes with magnesium chloride and titanium() chloride has been prepared and characterised by C CP MAS NMR spectroscopy.
  52. [52]
    The Use of the Titanium Tetrachloride (TiCl4) Catalysts as a ...
    Dec 1, 2024 · This review explores the potential for TiCl4 to catalyse various examples, adhering to the classic catalyst definition and allowing for the use ...
  53. [53]
    Catalysis and regioselectivity of quinone Diels–Alder reactions ...
    In a series of six different cycloadditions of unsymmetrical quinones and alkyl-substituted butadienes, TiCl4 afforded considerable catalysis (–78 °C) and ...
  54. [54]
    [PDF] Diastereoselection in Lewis-Acid-Mediated Aldol Additions
    The subject of this review is to rationalize the various stereochemical results of the Mukaiyama reactionsthe Lewis-acid-mediated aldol addition. II. Additions ...
  55. [55]
  56. [56]
    74. Titanium tetrachloride as a catalyst in the Friedel–Crafts reaction ...
    74. Titanium tetrachloride as a catalyst in the Friedel–Crafts reaction. Part I. Acylation. N. M. Cullinane, S. J. Chard and D. M. Leyshon. Abstract. The first ...
  57. [57]
    Titanium(IV) Chloride-Mediated Ortho-Acylation of Phenols and ...
    The document discusses the use of titanium(IV) chloride (TiCl4) as a Lewis acid for the direct ortho-acylation of phenols and naphthols, providing a convenient ...
  58. [58]
    TiCl4‐Promoted Asymmetric Aldol Reaction of Oxazolidinones and ...
    Sep 23, 2021 · The use of titanium (Ti)-enolates of chiral auxiliaries in asymmetric aldol reactions finds significant interest to construct an asymmetric ...
  59. [59]
    Asymmetric reactions catalyzed by chiral titanium complexes
    This presentation reviewed some of our recent progress in asymmetric reactions catalyzed by chiral Ti(IV) complexes, including asymmetric oxa-Diels-Alder ...
  60. [60]
    Chapter 7: Titanium-based Catalysts for Asymmetric Transformations
    Nov 16, 2015 · Titanium is employed with success in a wide range of enantioselective reactions, including oxidations, reductions, nucleophilic additions and ...<|control11|><|separator|>
  61. [61]
    Titanium Tetrachloride | ToxFAQs™ | ATSDR - CDC
    Titanium tetrachloride is very irritating to the eyes, skin, mucous membranes, and the lungs. Breathing in large amounts can cause serious injury to the lungs.
  62. [62]
    HEALTH EFFECTS - Toxicological Profile for Titanium Tetrachloride
    1987; NIOSH 1980). The results suggest that pulmonary impairment may be caused by exposure to titanium tetrachloride. Medical examinations, chest X-rays, and ...Missing: phased | Show results with:phased
  63. [63]
    [PDF] Titanium tetrachloride - U.S. Environmental Protection Agency
    Physical Properties. The chemical formula for titanium tetrachloride is TiCl. 4. , and its molecular weight is 189.73 g/mol. (4). Titanium tetrachloride occurs ...
  64. [64]
    Safe Handling and Storage of Titanium Tetrachloride (TiCl4)
    Oct 12, 2025 · When it comes to storage, TiCl4 must be kept in tightly sealed, corrosion-resistant containers, typically made of glass, Teflon, or ...
  65. [65]
    None
    ### Summary of Titanium(IV) Chloride (SIGALD - 254312) Safety Data Sheet
  66. [66]
    [PDF] SAFETY DATA SHEET - Fisher Scientific
    Apr 9, 2010 · Titanium(IV) chloride causes severe skin burns and eye damage, may cause respiratory irritation, and is fatal if inhaled. It reacts violently ...
  67. [67]
    [PDF] titanium-tetrachloride-sds_us-english.pdf - INEOS Group
    Sep 29, 2020 · Use only outdoors or in a well-ventilated area. Wear appropriate personal protective equipment. Observe good industrial hygiene practices.
  68. [68]
    [PDF] titanium (iv) chloride - s d fine-chem limited
    Neutralise remaining product with soda ash or slaked lime which is slurried with water. Wash spill area with large quantities of water. If contamination of ...
  69. [69]
    [PDF] 5. POTENTIAL FOR HUMAN EXPOSURE
    Environmental Fate.​​ Titanium tetrachloride readily hydrolyzes upon contact with moisture to form hydrochloric acid, titanium dioxide, and titanium oxychloride ...Missing: Cl2 | Show results with:Cl2
  70. [70]
    Exploring the Chloride Route for Titanium Dioxide Production
    Mar 9, 2024 · Environmental Impact: With the ability to recycle chlorine gas and lower emissions, the chloride route is considered more environmentally ...
  71. [71]
    [PDF] Proposed Rule for Mandatory Reporting of Greenhouse Gases
    Jan 22, 2009 · This heat is used in the previously discussed chloride process to produce titanium dioxide. These combustion emissions of greenhouse gases are ...
  72. [72]
    [PDF] Safety Data Sheet: Titanium tetrachloride - Chemos GmbH&Co.KG
    Disposal considerations: see section 13. SECTION 7: Handling and storage. 7.1. Precautions for safe handling. Recommendations. - Measures to prevent fire as ...
  73. [73]
    Titanium Tetrachloride | Public Health Statement | ATSDR - CDC
    Titanium tetrachloride is corrosive because it reacts strongly with water to produce hydrochloric acid. The reaction products, especially hydrochloric acid, ...
  74. [74]
    Critical raw materials: BAM researches more sustainable titanium ...
    Aug 6, 2025 · The EURO-TITAN project aims to reduce Europe's dependence on titanium imports while contributing to climate protection by developing a more ...
  75. [75]
    Closing the loop on the EU's titanium supply chain - EU Science Hub
    Jan 23, 2025 · A new JRC report explores the supply chain of titanium metal and how increasing circularity can cut imports.Missing: dioxide | Show results with:dioxide<|separator|>