Fact-checked by Grok 2 weeks ago

Walter Reed

Walter Reed (September 13, 1851 – November 23, 1902) was an American pathologist and U.S. Army medical officer renowned for directing the United States Army Yellow Fever Commission, which conclusively demonstrated through human experiments that yellow fever is transmitted exclusively by the bite of the Aedes aegypti mosquito, overturning prevailing theories of direct human contact or contaminated fomites.^[1]^[2] Born in Gloucester County, Virginia, Reed graduated from the University of Virginia School of Medicine at age 18 and joined the Army Medical Corps in 1875, rising to major by 1898 amid the Spanish-American War's disease crises.^[3]^[4] In 1900, appointed by Surgeon General George Sternberg, Reed led a commission including Aristides Agramonte, James Carroll, and Jesse Lazear to investigate yellow fever outbreaks in Cuba, building on Cuban physician Carlos Finlay's mosquito hypothesis while rigorously testing alternatives like the filth theory.^[5] Their Camp Lazear experiments, involving controlled exposures of volunteers—including self-experimentation by Carroll and fatal infection of Lazear—provided empirical proof of mosquito vector transmission, enabling subsequent public health measures like vector control that eradicated yellow fever from Havana within months.^[1]^[2] Reed's prior work on typhoid fever epidemiology, identifying Salmonella typhi as the causative agent via autopsy studies, further established his expertise in infectious disease causation.^[4] Reed's discoveries laid foundational principles for modern vector-borne disease control and earned him posthumous honors, including the naming of Walter Reed Army Medical Center and a 1940 U.S. postage stamp; he died prematurely from appendicitis complications at age 51, shortly after promotion to professor of bacteriology at the Army Medical School.^[3]^[4] The commission's primary records, preserved in collections like the Philip S. Hench Walter Reed Yellow Fever archive, underscore the empirical rigor of their methods amid high personal risks, contrasting with less verifiable contemporary accounts.^[6]

Early Life

Family Background and Upbringing

Walter Reed was born on September 13, 1851, in Belroi, Gloucester County, Virginia, in a small parsonage house to Lemuel Sutton Reed, a Methodist Episcopal minister, and his wife Pharaba White Reed.^[7]^[8] He was the youngest of five children born to the couple.^[7] Lemuel Reed's vocation as an itinerant preacher required the family to relocate frequently across Virginia and into North Carolina, including a move to Murfreesboro, North Carolina, in 1853 when Walter was approximately two years old.^[9] This peripatetic lifestyle defined Reed's early childhood, exposing him to varied communities while his father's ministry emphasized Methodist principles of discipline and service.^[10] The family eventually settled in Charlottesville, Virginia, providing a more stable environment amid the post-Civil War recovery, where Reed's upbringing fostered an early interest in learning despite the disruptions of frequent moves.^[11]^[10]

Education and Initial Medical Training

Reed received his early education at home under the tutelage of his father, Reverend Lemuel Sutton Reed, a Methodist minister who emphasized literature, Latin, mathematics, and natural observation.^[3] This foundational preparation enabled Reed, born on September 13, 1851, in rural Gloucester County, Virginia, to demonstrate exceptional aptitude from a young age.^[10] At age 15, in 1866, Reed enrolled as an undergraduate at the University of Virginia in Charlottesville, where his family had relocated to facilitate access to higher education.^[10] After one year of preparatory studies, he advanced to the medical curriculum, completing the nine-month graded program at an accelerated pace and earning his Doctor of Medicine degree in July 1869 at age 17—the youngest recipient in the university's history at that time.^[12] The University of Virginia's medical program, lacking an affiliated hospital for clinical practice, focused primarily on didactic instruction in anatomy, physiology, pathology, and therapeutics.^[4] Seeking hands-on clinical experience unavailable at UVA, Reed relocated to New York City and enrolled at Bellevue Hospital Medical College (affiliated with New York University), where he interned at Bellevue Hospital and earned a second M.D. degree in 1870.^[10] This training emphasized practical application through hospital rotations, exposing him to patient care in internal medicine, surgery, and public health amid the era's urban disease burdens.^[13] These early qualifications positioned Reed for his subsequent entry into military medicine, though formal residency programs as known today did not yet exist.^[14]

Personal Life

Marriage and Family

Walter Reed married Emilie Blackwell Lawrence, a resident of Murfreesboro, North Carolina, in 1876 following his commissioning in the U.S. Army Medical Corps.^[14]^[8] The couple's union provided personal stability amid Reed's itinerant military career, with Emilie joining him at postings such as Fort Lowell in Arizona Territory shortly after their marriage.^[15] They had two children: a son, Walter Lawrence Reed, born on December 4, 1877, at Fort Apache, Arizona Territory, and a daughter, Emilie Reed (often called Polly), born in 1880 in Washington, D.C.^[16]^[8] The Reeds also adopted a Native American orphan girl, raising her as part of the family during their time in the American Southwest.^[17]^[18] Emilie Reed outlived her husband by nearly five decades, passing away in 1950 at the age of 94.^[19] The family frequently relocated with Reed's assignments, enduring the challenges of frontier army life, though specific details on their domestic dynamics remain limited in primary records.^[3]

Army Medical Career

Commissioning and Early Assignments

Reed passed the rigorous entrance examination for the U.S. Army Medical Corps on February 8, 1875, enduring a 30-hour ordeal that included essays on contemporary medical issues such as cholera treatment.^[10] He was subsequently commissioned as a first lieutenant and assistant surgeon in the Medical Department of the U.S. Army on June 26, 1875, entering service amid post-Civil War reconstruction efforts to professionalize military medicine.^[11]^[10] His initial posting was to Fort Clark in Brackettville, Texas, a frontier outpost where he provided medical care to soldiers, Native Americans, and civilians, primarily managing outbreaks of typhoid fever, dysentery, and other infectious diseases prevalent in the harsh border environment.^[4] Early in his career, Reed's assignments reflected the itinerant nature of Army physicians, involving frequent relocations to remote posts with limited resources and high disease burdens; these included Fort Brown, Texas, Fort McHenry in Maryland, and Fort Lyon in Colorado, often requiring him to improvise treatments under field conditions while accompanying his wife on these travels.^[11]^[4] During these years, Reed gained practical experience in epidemiology and sanitation, documenting cases of communicable illnesses that informed his later research interests, though his duties focused on routine garrison medicine rather than specialized investigation.^[11] By the early 1880s, he had advanced to roles such as acting assistant surgeon at various stations, building a foundation in military hygiene amid ongoing challenges like inadequate infrastructure and exposure to endemic pathogens.^[4]

Research on Infectious Diseases Prior to Yellow Fever

In 1893, Walter Reed assumed the role of professor of bacteriology (later expanded to include pathology) at the Army Medical School in Washington, D.C., where he advanced studies on the etiology and microscopy of infectious diseases such as cholera, typhoid fever, and malaria.^[10] In 1896, Reed investigated a smallpox outbreak in Key West, Florida, implementing quarantine and vaccination measures to curb its spread. That same year, he probed a malaria epidemic among workers constructing the Florida East Coast Railway, identifying stagnant water pools near the worksite as breeding grounds for infected mosquitoes, which supported emerging theories of arthropod transmission despite prevailing debates on miasmatic origins.^[10]^[20] Reed's most extensive pre-yellow fever inquiry addressed typhoid fever epidemics in U.S. Army camps during the Spanish-American War, where over 20,000 cases and 1,500 deaths occurred among 100,000 troops by mid-1898, far exceeding combat losses. On August 18, 1898, the War Department established the Typhoid Board, appointing Reed as president alongside Majors Victor C. Vaughan and Edward O. Shakespeare, to systematically examine transmission in camps like those at Huntsville, Alabama, and Chickamauga, Georgia.^[21]^[11] Employing the Widal agglutination test for serological confirmation—validating its diagnostic reliability through controlled trials—the board analyzed necropsy data, water samples, and epidemiological patterns across 92 regiments. Their 1904 final report, exceeding 3,000 pages with 100 maps and charts, issued 57 conclusions attributing outbreaks primarily to contact spread via fecal-oral routes: chronic human carriers contaminating food, flies disseminating pathogens from latrines to messes, and fomites in unsanitary conditions, while downplaying pure water-borne dissemination as insufficient to explain the data's geographic inconsistencies. This evidence-based refutation of dominant hydrographic theories prompted reforms in military hygiene, including fly screens, protected food handling, and latrine distancing, reducing subsequent camp morbidity.^[21]^[11]

Yellow Fever Commission

Formation and Objectives

In June 1900, amid persistent yellow fever outbreaks in Cuba that impeded U.S. military operations following the Spanish-American War, U.S. Army Surgeon General George Miller Sternberg established the Yellow Fever Commission to investigate the disease's transmission.^[13] Sternberg appointed Major Walter Reed, a pathologist and bacteriologist with prior experience in infectious diseases, to lead the four-member board.04943-6/fulltext) The commission was based in Havana, where Reed arrived on July 20, 1900, to oversee experiments amid competing theories attributing yellow fever to contaminated water, sewage, or direct contact with patients.^[10] The team comprised Reed as director, Major James Carroll (a pathologist who assisted in autopsies), Major Jesse William Lazear (with entomological expertise), and Major Aristides Agramonte y Simoni (a Cuban-born pathologist familiar with local strains).04943-6/fulltext) This composition reflected the Army's intent to blend medical, pathological, and field observational skills, with operations funded by the U.S. government and conducted under military auspices to address sanitary failures that had caused over 1,000 U.S. troop deaths in prior epidemics.^[22] Initial efforts focused on verifying prior claims, including Cuban physician Carlos Finlay's 1881 hypothesis of mosquito vector transmission via the Stegomyia fasciata (now Aedes aegypti).^[1] The commission's core objectives were to empirically determine yellow fever's causative agent and transmission mechanism through controlled experiments, disproving non-vector theories dominant in U.S. medicine, such as those positing bacterial origins or fomite spread.^[13] Reed emphasized rigorous, replicable methods, including human volunteer trials with informed consent, to isolate variables like mosquito bites versus contact with infected materials.^[22] Success in these aims was critical for enabling effective sanitation campaigns, as evidenced by later applications in Panama Canal construction, underscoring the board's practical goal of curbing epidemics that had historically devastated tropical deployments.04943-6/fulltext)

Experimental Design and Human Trials

The U.S. Army Yellow Fever Commission, under Major Walter Reed, conducted controlled human experiments in Cuba starting in June 1900 to determine the mode of yellow fever transmission, as no suitable animal model existed. Initial work at Las Animas Hospital in Havana tested theories of bacterial causation and direct contact, but pivotal trials focused on vector transmission by ruling out fomites and contaminated fluids while isolating mosquito bites as the causal mechanism. Experiments employed strict isolation protocols, including a purpose-built facility called Camp Lazear, established outside Havana by November 1900, to minimize external exposures and ensure controlled conditions. Mosquitoes (Culex fasciatus, now Aedes aegypti) were captured, fed on actively infected patients during the first three days of illness, held for 12–18 days to allow viral incubation (the extrinsic cycle), and then applied to volunteers' arms under observation. Control groups received bites from non-infectious mosquitoes or exposures to filtered blood/serum to exclude bacterial agents, with all subjects monitored for symptoms like fever, jaundice, and albuminuria.^[23]^[1] Human trials involved approximately 20–25 volunteers across phases, primarily U.S. soldiers, Spanish immigrants, and commission members, motivated by financial incentives ($100–$200 base pay, plus $100–$300 bonuses for contraction, equivalent to several months' wages) and patriotic duty. Informed consent was obtained via written contracts starting November 26, 1900—one of the earliest documented instances in medical research—detailing risks and transmission hypotheses, though earlier phases relied on verbal agreements. Phase I (August 1900) featured self-experimentation: Assistant Surgeon James Carroll allowed a mosquito bite on August 27, developing confirmed yellow fever symptoms by August 31, including high fever and liver damage, from which he recovered but with lasting cardiac effects; Private William Dean was similarly infected on September 6, providing the first non-self case verifying mosquito transmission. Assistant Surgeon Jesse Lazear, who had inoculated himself earlier, died on September 25, 1900, likely from a subsequent accidental mosquito exposure during field collections.^[23]^[1]^[23] Phase II trials at Camp Lazear (November 1900) expanded to group exposures: of seven volunteers bitten by 12-day-incubated mosquitoes from infected patients, four (including Privates John R. Kissinger, Tony Grayson, and Pablo Morales) contracted the disease within 5–6 days, exhibiting classic symptoms, while controls exposed to fomites (bedding and clothing from deceased patients) remained healthy after two weeks. Parallel blood injection trials confirmed a filterable agent: three of four volunteers injected with unfiltered blood from early-stage patients developed yellow fever, but none did from filtered serum, indicating a sub-bacterial pathogen. Phase III (August 1901) at a Havana hospital tested antiserum efficacy with about 10 volunteers, including nurse Clara Maass, but yielded three fatalities, highlighting ongoing risks despite preventive insights. These trials collectively demonstrated mosquito-mediated transmission with high specificity, as non-vector exposures failed to produce illness in susceptible subjects.^[1]^[23]^[1]

Key Discoveries and Causation Proof

The Yellow Fever Commission, under Reed's leadership, first disproved the prevailing theory of transmission via fomites such as contaminated bedding or clothing. In controlled experiments conducted in Cuba starting in June 1900, volunteers were housed in isolated quarters at Camp Lazear and exposed to items directly from yellow fever patients, including pajamas, sheets, and mosquito netting, without developing the disease, provided no mosquitoes were present.^[13]^[24] This refuted earlier hypotheses of direct contact or airborne particles as primary vectors.04943-6/fulltext) Subsequent experiments established mosquito transmission as the causal mechanism. Commission member Jesse Lazear demonstrated in September 1900 that Aedes aegypti mosquitoes, after feeding on infected patients during the first three days of illness, could transmit the pathogen via bites, though Lazear himself succumbed to yellow fever on September 25, 1900, likely from an experimental bite.^[25]^[13] Reed's team then used human volunteers, including enlisted soldiers paid $100 in gold for participation, to confirm causation under Koch's postulates adapted for vector-borne diseases. Volunteers bitten by mosquitoes previously fed on yellow fever patients developed symptoms after an incubation period of 3 to 6 days, with fever onset proving direct transmission.^[24]04943-6/fulltext) Key human trials at Camp Lazear in October 1900 involved nine volunteers exposed to infected mosquitoes; five contracted yellow fever, including Private John R. Kissinger, who exhibited classic symptoms after a bite on October 11 and recovered.^[24] No illnesses occurred among controls isolated from mosquitoes, establishing specificity. Further tests showed the pathogen passes through filters excluding bacteria, indicating a submicroscopic agent, later identified as a virus, rather than a bacterial cause.^[26] Reed reported these findings on February 4, 1901, to the Pan-American Medical Congress in Havana, with publication in the Journal of the American Medical Association confirming Aedes aegypti as the vector.^[27] These results provided rigorous causation proof by demonstrating necessity (disease absent without vector exposure), sufficiency (bites reliably induced illness), and exclusion of alternatives through isolation and controls. The experiments required an extrinsic incubation period of 10 to 14 days in the mosquito before transmissibility, aligning with field epidemiology.^[13]04943-6/fulltext) No ethical lapses in consent were noted in primary records, as volunteers were informed and compensated amid high military mortality risks from the disease.^[24]

Later Career and Death

Administrative Roles and Promotions

Following the conclusion of the Yellow Fever Commission in late 1901, Reed returned to Washington, D.C., and resumed his longstanding administrative duties at the Army Medical School, where he had served since 1893 as professor of bacteriology (later designated professor of clinical and sanitary microscopy) and curator of the Army Medical Museum.^[10]^[4] These roles involved overseeing pathological collections, instructing medical officers in microscopy and bacteriology, and advancing Army pathology research amid expanding U.S. military commitments post-Spanish-American War.^[10] In recognition of his contributions to infectious disease control, particularly yellow fever transmission, U.S. Secretary of War Elihu Root recommended Reed's elevation to Assistant Surgeon General, which would have carried the rank of colonel—a significant advancement from his existing major's commission achieved in 1893.^[10] This proposed promotion reflected Reed's growing influence in military medicine but remained unrealized due to his sudden illness and death in November 1902.^[10] No further formal promotions occurred in the brief interval between the commission's findings and his passing.

Illness and Death

In November 1902, Walter Reed developed acute appendicitis while serving in Washington, D.C.^[28] ^[3] On November 17, he underwent an appendectomy performed by U.S. Army surgeon Major William C. Borden at the Army Medical School.^[29] ^[30] Postoperative complications arose rapidly, including peritonitis resulting from the ruptured appendix and potential surgical infection.^[28] ^[8] Despite treatment, Reed's condition deteriorated, and he died on November 23, 1902, at age 51.^[3] ^[29] Borden, who had successfully performed numerous appendectomies, regarded Reed's death as his only such loss and expressed profound regret over the outcome.^[30] ^[28] Reed was interred at Arlington National Cemetery, where his gravestone bears an epitaph noting his contributions to medicine.^[8] The precise underlying cause of the appendicitis remains unclear, though it was unrelated to yellow fever exposure from his earlier research.^[28]

Legacy

Impact on Public Health and Medicine

Reed's confirmation in 1900 that yellow fever is transmitted solely by the Aedes aegypti mosquito, rather than through direct contact or fomites, enabled targeted public health interventions that dramatically reduced the disease's incidence.^[13] In Havana, Cuba, U.S. Army physician William C. Gorgas applied these findings starting in early 1901 by isolating patients in screened facilities to prevent mosquito bites, eliminating breeding sites in water containers, and fumigating buildings with infected mosquitoes. This resulted in the near-elimination of yellow fever cases within three months, marking the first time in over 150 years the city was free from the disease.^[31] The principles derived from Reed's experiments were pivotal to the success of the Panama Canal project. French efforts from 1881 to 1889 had failed amid yellow fever outbreaks that killed an estimated 20,000 workers, but after the U.S. assumed control in 1904, Gorgas implemented mosquito eradication measures informed by Reed's work, including widespread drainage, oiling of stagnant water, and house screening. Yellow fever deaths dropped to just a handful—five confirmed cases in 1905—allowing construction to proceed with minimal disease-related interruptions and enabling completion in 1914.^[13] ^[32] Reed's research shifted medical paradigms from miasmatic theories to vector-based transmission models, influencing global strategies against other mosquito-borne diseases like malaria. His emphasis on controlled human experimentation to establish causation advanced epidemiological methods, providing a rigorous framework for proving non-bacterial disease vectors that complemented Koch's postulates and facilitated later vaccine developments, such as Max Theiler's 1937 yellow fever vaccine.^[33] In military contexts, these insights reduced troop morbidity and mortality from tropical diseases, as evidenced by lower infection rates during subsequent U.S. campaigns in endemic areas.^[15] Overall, the causal identification enabled by Reed's team is credited with saving millions of lives through sustained sanitation and vector control programs worldwide.^[10]

Honors, Memorials, and Enduring Influence

In recognition of his contributions to medical science, the United States Postal Service issued a 5-cent stamp featuring Walter Reed on April 17, 1940, as part of the Famous Americans series.^[34] The American Society of Tropical Medicine and Hygiene annually awards the Walter Reed Medal for distinguished accomplishments in tropical medicine, honoring his pioneering work on vector-borne diseases.^[35] Reed's name is inscribed on the frieze of the London School of Hygiene & Tropical Medicine's Keppel Street building, alongside other key figures in public health and epidemiology.^[36] Several major institutions bear Reed's name, reflecting his lasting impact on military medicine. The Walter Reed General Hospital, established on May 1, 1909, in Washington, D.C., was renamed Walter Reed Army Medical Center in 1951 and served as a premier U.S. Army facility until its closure in 2011.^[37] It merged with the National Naval Medical Center to form the Walter Reed National Military Medical Center in Bethesda, Maryland, which continues to operate as the U.S. military's flagship medical institution.^[37] The Walter Reed Army Institute of Research (WRAIR), originating in 1893 as the Army Medical School laboratory and formally named after Reed, remains the U.S. Department of Defense's largest biomedical research facility, focusing on infectious diseases and soldier health.^[38] Reed's proof of mosquito transmission for yellow fever revolutionized infectious disease control, shifting strategies from ineffective sanitation measures to targeted vector eradication, which drastically reduced outbreaks in endemic areas.^[39] This breakthrough enabled General William Gorgas to implement mosquito control in Panama, facilitating the Panama Canal's completion in 1914 after prior French failures due to disease.^[39] His emphasis on empirical experimentation over prevailing theories influenced modern epidemiology and public health policy, prioritizing causal mechanisms like arthropod vectors in disease prevention worldwide.^[40] WRAIR's ongoing research in vaccines, diagnostics, and treatments for threats like malaria and HIV extends Reed's legacy, supporting global health initiatives and military readiness.^[41]

Ethical Evaluations of Human Experimentation

The human experiments conducted by Major Walter Reed's Yellow Fever Commission between November 1900 and 1901 involved deliberately exposing 22 volunteers—primarily U.S. Army enlisted men and civilians in Cuba—to yellow fever pathogens, either via infected mosquito bites or contaminated fomites, to test transmission modes.^[23] These trials built on prior filtration and animal studies but required human subjects to resolve debates over mosquito vectors versus contact transmission, as natural infection rates varied unpredictably.^[42] Volunteers signed written consent forms detailing risks, including possible death from the disease, which had a 20-50% fatality rate in untreated cases, marking the earliest documented systematic use of informed consent in biomedical research.^[43] ^[44] At the time, the experiments garnered acclaim for their rigor and self-sacrifice, with Reed's team members, including Aristides Agramonte and James Carroll, subjecting themselves to bites from potentially infected Aedes aegypti mosquitoes; Carroll contracted yellow fever on December 27, 1900, but recovered, providing key virological data.^[43] Participants received financial incentives—$200 for exposure without illness and up to $500 if infected—framed as compensation rather than coercion, though Surgeon General George Sternberg prohibited using unwilling soldiers and allocated funds specifically for civilian volunteers.^[23] No deaths occurred directly under Reed's oversight, but the work's extension by others, such as nurse Clara Maass's fatal infection on August 24, 1901, after mosquito inoculation, highlighted the inherent dangers.^[45] Contemporary accounts, including Reed's 1901 reports to the American Philosophical Society, emphasized ethical safeguards like quarantine isolation and medical monitoring, positioning the trials as a moral imperative to combat a scourge that killed over 100,000 during the Spanish-American War era.^[46] Modern ethical scrutiny, informed by post-World War II codes like the 1947 Nuremberg Code and 1964 Declaration of Helsinki, critiques the trials for lacking independent oversight, potential undue inducement via payments to low-income subjects (many recent immigrants or privates earning $13 monthly), and exposing healthy individuals to non-therapeutic risks without guaranteed personal benefit.^[1] ^[47] Critics argue that military hierarchy may have pressured enlistees, despite signed waivers, and that the experiments prioritized collective public health gains—ultimately enabling mosquito control that eradicated urban yellow fever in the Americas by the 1950s—over individual autonomy, a tension echoed in later human challenge studies.^[48] Academic analyses, such as those in bioethics journals, note anachronistic application of contemporary standards, as pre-1900 precedents like Edward Jenner's smallpox variolation involved unconsented risks, yet Reed's explicit documentation advanced voluntary participation norms.^[49] Defenders, drawing from primary records, highlight the trials' causal realism: volunteers, often believing themselves immune or motivated by patriotism and pay, faced risks comparable to routine Cuban service where yellow fever mortality exceeded 10% annually; the 1900 consent form's language—"I hereby voluntarily consent... fully understanding the nature and extent of the risks"—demonstrates transparency absent in many era experiments.^[50] The commissions' success, proving mosquito transmission on November 23, 1900, via controlled infections without fomite failures, yielded empirical validation that saved millions, substantiating risk-benefit calculus under first-principles evaluation of preventable disease burdens.^[42] While some sources from academia reflexively emphasize vulnerabilities, potentially influenced by institutional emphases on equity over efficacy, the experiments' legacy underscores early prioritization of verifiability and voluntarism, influencing ethical frameworks like the U.S. Common Rule.^[23] No evidence indicates deception or force, distinguishing Reed's work from later abuses like the Tuskegee syphilis study.^[43]

References

[1]
Walter Reed and the Scourge of Yellow Fever - UVA Today
Nov 13, 2019 · UVA alumnus Walter Reed led the US Army Yellow Fever Commission in Cuba. The team proved that yellow fever was spread by mosquitoes.
[2]
Walter Reed: Get to Know the Man Behind the Medical Center
Feb 5, 2021 · By 1900, Reed was appointed to head the four-person Yellow Fever Commission to investigate infectious diseases in Cuba. They learned yellow ...
[3]
Walter Reed - National Museum of the United States Army
Walter Reed died from appendicitis complications on Nov. 23, 1902 ... Walter Reed National Military Medical Center on the 100th anniversary of his birth.
[4]
Walter Reed - A Name for the Ages
Dec 22, 2022 · Reed's outstanding work on typhoid earned him more work as head of the U.S. Army Yellow Fever Board even before the typhoid report was completed ...Missing: commission | Show results with:commission
[5]
Yellow Fever - PMC
Following an outbreak of yellow fever in Havana at the turn of the 20th century, the U.S. Army assigned Reed to head a commission to study the disease.
[6]
Philip S. Hench Walter Reed Yellow Fever Collection
Feb 13, 2025 · The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the ...
[7]
Walter Reed: A Biographical Sketch | JAMA Internal Medicine
Walter Reed, born Sept 13, 1851, at Belroi near Gloucester, in tidewater Virginia, was the youngest of five children. His parents, Lemuel Sutton Reed, ...Missing: family background birthplace
[8]
Dr. Walter Reed (1851-1902)- Conqueror of the Yellow Fever
Nov 2, 2024 · Walter Reed (1851-1902), born here, later became a doctor and while a member of the Army Medical Corp conquered yellow fever.Missing: achievements | Show results with:achievements<|control11|><|separator|>
[9]
Dr. Walter Reed (A-52) - NC DNCR
Dec 1, 2023 · In 1900 Reed led the fourth U. S. Army Yellow Fever Commission, medical officers appointed to study the transmission of the disease. Because ...
[10]
Walter Reed (1851-1902) | American Experience | Official Site - PBS
His father, a pastor, moved frequently to minister to different parishes, later settling his family in Charlottesville, near the University of Virginia. Under ...Missing: upbringing | Show results with:upbringing
[11]
The United States Army | Page not found
No readable text found in the HTML.<|separator|>
[12]
Walter Reed | Encyclopedia.com
Walter Reed (1851-1902), American military surgeon and head of the U.S. Army Yellow Fever Commission, is widely known as the man who conquered yellow fever by ...Missing: achievements | Show results with:achievements
[13]
Major Walter Reed and the Eradication of Yellow Fever
He received an additional degree in 1870 at Bellevue Hospital Medical College in New York. Reed's experience interning in hospitals in New York helped him ...
[14]
Dr. Walter Reed (A-60) - NC DNCR
Dec 5, 2023 · Reed was born on September 13, 1851, in Virginia to ... Walter Reed died of complications resulting from appendicitis on November 23, 1902.Missing: achievements | Show results with:achievements
[15]
Walter Reed | Research Starters - EBSCO
He died in 1902, leaving a legacy that continues to influence tropical medicine and public health practices today. Published in: 2023. By: Kiple, Kenneth F.
[16]
Walter Reed MD (1851-1902) | WikiTree FREE Family Tree
May 29, 2024 · Walter Reed was born in Gloucester County, Virginia, to Lemuel Sutton Reed (a Methodist minister) and Pharaba White. He is (still) the youngest ...Missing: upbringing | Show results with:upbringing
[17]
Walter Reed Biography - Garden of Praise
He married Emilie Lawrence and they had two children, a son and a daughter. They also adopted an Indian girl. Walter was a very young doctor. He thought he ...Missing: family | Show results with:family
[18]
History Minute: The Early Life of Walter Reed - El Dorado News-Times
Apr 15, 2020 · At the age of 15, Reed enrolled at the University of Virginia with his oldest brothers. He devoured books, sometimes only sleeping three or ...
[19]
Dr. Walter Reed's Widow Dies in East at 94
She was 94. Born in Murfreesboro, N. C., she was married to Dr. Reed in 1876, when he was a first lieutenant in the Army Medical Corps.
[20]
[PDF] Walter Reed (1851–1902): on the cause of yellow fever - SMJ
Reed then enrolled at the. University of Virginia, receiving his medical degree at age 18, the youngest graduate in the school's history. During the following ...
[21]
War Department's Creation of the Typhoid Board Headed by Walter ...
The Department appointed three army surgeons recommended by the Surgeon-General: Major Walter Reed, designated President of the board, and Majors Edward O.
[22]
The Legacy of Walter Reed - National Museum of Health and Medicine
Jun 23, 2025 · Caption: The 1900 Yellow Fever Commission, headed by Maj. Reed, was the first recorded use of informed consent in human research. As this ...
[23]
Politics of Participation: Walter Reed's Yellow-Fever Experiments
Reed's experiments were a scientific success and instrumental in establishing that yellow fever was a mosquito-borne illness.
[24]
the yellow fever volunteers - PubMed
Beginning its work in June 1900 in the midst of a deadly epidemic, the board conducted a truly remarkable set of experiments that set a benchmark for controlled ...
[25]
Yellow Fever in America | American Experience | Official Site - PBS
September 25: Jesse Lazear, likely bitten by a mosquito used in his experiments, dies of yellow fever. October 23: Walter Reed presents a "Preliminary Note" ...
[26]
Yellow Fever: 100 Years of Discovery | Global Health - JAMA Network
Aug 27, 2008 · Reed's work proved that Aedes aegypti mosquitoes were the primary mode of transmission for the disease and that yellow fever was caused by a ...
[27]
Reed Reports That Mosquitoes Transmit Yellow Fever - EBSCO
Walter Reed established that yellow fever was caused by an unknown infectious agent being transmitted by the Aëdes mosquito, thereby laying the basis for ...Missing: primary | Show results with:primary
[28]
The Death of Walter Reed - JAMA Network
Walter Reed did die of peritonitis following an appendectomy. But his death remains a mystery. What ailed him and his appendix is not known.
[29]
DEATH LIST OF A DAY.; Major Walter Reed. - The New York Times
His death was due to appendicitis, for which an operation was performed Nov. 17. Major Reed was born in Gloucester County, Va., in 1851, and was a graduate of ...
[30]
History/Legacy - Walter Reed Society
History & Legacy. Walter Reed General Hospital opened it doors on May 1, 1909. The commander of the Army General Hospital, Major William C.
[31]
The Work of Walter Reed and His - Associates of the Medical ...
He screened yellow fever patients, destroyed mosqui- toes, etc., and in 3 months Havana was freed from the disease for the first time in 150 years. The success ...Missing: prior | Show results with:prior
[32]
Yellow Fever Control and the Construction of the Panama Canal - NIH
This essay argues, to the contrary, that yellow fever control was a process of reengineering urban Panama and of disciplining an urban Panamanian population.
[33]
Walter Reed: A Biography - JAMA Network
The brilliant researches of Walter Reed proved that the mosquito Aedes aegypti transmitted yellow fever. This work, carried out with several.
[34]
5c ultramarine Walter Reed single | Smithsonian Institution
Depicts: Walter Reed, American, 1851 - 1902 ; Description: mint; perf 10.5 x 11 ; Date: April 17, 1940 ; Object number: 1980.2493.2863 ; Type: Postage Stamps.
[35]
Walter Reed Medal - ASTMH
The Walter Reed Medal is awarded every year to recognize distinguished accomplishments in the field of tropical medicine.Missing: memorials | Show results with:memorials
[36]
Behind the frieze | History | LSHTM
Twenty-six names form the frieze on the exterior of LSHTM's Keppel Street building. ... Walter Reed. Army pathologist and bacteriologist who led the experiments ...
[37]
Our Rich History - Walter Reed National Military Medical Center
The original Medical Center was designed to hold 1,200 beds, the Naval Medical School, the Naval Dental School, and the Naval Medical Research Institute. In ...
[38]
WRAIR's History - Walter Reed Army Institute of Research
Since 1893, the Walter Reed Army Institute of Research (WRAIR) has been a leader in solving the most significant threats to Soldier readiness and lethality.
[39]
Military Medicine's Value to US Health Care and Public Health
Sep 21, 2023 · The groundbreaking work of Major Walter Reed and General William Gorgas not only protected US troops from malaria and yellow fever; it ...
[40]
https://www.wordsofveterans.com/walter-reed-defeating-yellow-fever-and-changing-medical-history/
[41]
Our History and Relevance
WRAIR, founded in 1893, has led the development of new vaccines, drugs, diagnostics and public health strategies, including products against malaria, HIV, ...
[42]
Walter Reed and the Yellow Fever Experiments - Oxford Academic
Oct 31, 2023 · Through a series of elegant and painstaking experiments, the members of the Yellow Fever Commission demonstrated that yellow fever was not transmitted via ...
[43]
The centennial of the Yellow Fever Commission and the ... - PubMed
Informed consent was systematically used for the first time in research. This process was the result of a complex social phenomenon involving the American ...
[44]
Walter Reed | U.S. Department of War
The 1900 Yellow Fever Commission, headed by Army Maj. Walter Reed, was the first recorded use of informed consent in human research. As this consent form shows, ...
[45]
https://pubmed.ncbi.nlm.nih.gov/23756016/
[46]
Yellow fever Discovering the cause and designing effective ...
May 27, 2020 · We know that yellow fever is transmitted from person to person by mosquitoes, but back then we did not. This is the story of that discovery.
[47]
Walter Reed, Yellow Fever, and Informed Consent | Military Medicine
In July 1900, Walter Reed told Sternberg that human subject testing was the only option. The team also determined that they, too, would be put at risk.
[48]
History of Human Challenge Studies - PMC - NIH
Aug 19, 2020 · Subsequent attempts to develop a yellow fever vaccine in Cuba using a challenge study based on the work of Reed's team (and using a similar ...
[49]
Experimental infections in humans—historical and ethical reflections
Oct 26, 2019 · In 1900, Walter Reed, an American army surgeon, exposed test persons to mosquitoes infected with yellow fever virus in order to verify its mode ...
[50]
https://pubmed.ncbi.nlm.nih.gov/26741482/