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Worry

Worry is a pervasive cognitive and emotional process characterized by repetitive, often uncontrollable thoughts and about potential future threats or uncertainties, which evoke feelings of anxiety, apprehension, and distress. Unlike , which responds to immediate dangers, worry centers on anticipated or hypothetical negative events, ranging from everyday concerns like work performance to broader existential uncertainties. In its moderate form, worry functions as an adaptive mechanism to anticipate problems and facilitate planning, but when excessive, it becomes a maladaptive that interferes with daily life. Excessive worry is the defining feature of (GAD), a common condition with a 12-month of approximately 2.7% among U.S. adults and a lifetime of around 6%, according to 2001–2003 data. GAD typically emerges in late or early adulthood, affects women at nearly twice the rate of men, and is associated with physical symptoms such as muscle tension, , , and sleep disturbances. Pathological worry differs from normal worry in its pervasiveness, lack of control, and focus on low-probability catastrophic outcomes, often fueled by intolerance of and meta-worry (worry about worrying itself). From an evolutionary standpoint, worry likely developed as a survival tool, enabling early humans to simulate threats and rehearse responses, thereby reducing actual risks in unpredictable environments. In contemporary settings, however, chronic worry contributes to heightened responses, including elevated cortisol levels and overactivity, which can exacerbate health problems like impaired immune function and increased susceptibility to coronary heart disease. Effective management strategies include , which targets worry patterns through techniques like and exposure to uncertainty, often yielding significant improvements within 3-6 months.

Conceptual Foundations

Definition

Worry is defined in psychology as a chain of thoughts and images, negatively affect-laden and relatively uncontrollable, that imaginatively concern possible future negative events or outcomes perceived as threatening. This process centers on anticipatory concerns about potential threats, distinguishing it from constructive problem-solving by its repetitive, unproductive nature that often heightens rather than resolves distress. Key components of worry include the anticipation of future threats, accompanying emotional distress, and cognitive rumination characterized by verbal-linguistic processing over vivid imagery. In clinical contexts, worry serves as a hallmark symptom of (GAD) according to criteria, where it manifests as excessive anxiety and apprehensive expectation occurring more days than not for at least six months, involving multiple events or activities and proving difficult to control. This uncontrollable quality often leads to interference in daily functioning, marking a shift from adaptive vigilance to maladaptive preoccupation. Everyday worries typically involve manageable concerns, such as performance at work or upcoming deadlines, which may motivate action without overwhelming the individual. In contrast, pathological worry escalates to excessive and pervasive levels, like unfounded fears that dominate thoughts despite reassurance, contributing to anxiety disorders. The concept of worry in has evolved from early psychoanalytic views, where described "anxious expectation" as a core feature of anxiety tied to repressed libidinal tensions in the late , to modern cognitive frameworks. By the mid-20th century, diagnostic systems like DSM-III (1980) began separating GAD from other anxiety forms, but it was DSM-III-R (1987) that elevated worry as the defining cognitive symptom, reflecting a toward viewing it as a distinct mental process rather than mere emotional overflow. Contemporary definitions, pioneered by researchers like Thomas Borkovec in the , emphasize worry's role in cognitive avoidance and its verbal, future-oriented structure, integrating it into evidence-based models of anxiety.

Etymology and Historical Usage

The word "worry" originates from the verb wyrgan, meaning "to strangle" or "to choke," referring initially to the physical of an animal seizing and shaking its prey by the throat. This sense, derived from Proto-Germanic wurgjaną and linked to the wer- ("to turn, bend"), persisted into as worien or wirien, retaining connotations of harming or tormenting through biting and tearing. By around 1400, the term began to acquire figurative meanings of annoyance or vexation, evolving further by the early to denote and harassing anxiety, with the intransitive sense of "to feel anxious" attested from 1860. The noun form, meaning "a harassing anxiety" or "state of worry," first appeared in 1804. In early , "worry" largely maintained its physical and destructive implications, as evidenced by its rare appearance in Shakespeare's works—used only once in Richard III, referring to the physical act of seizing and shaking prey rather than abstract anxiety. By the , however, the term shifted toward psychological interpretations in both literary and contexts, reflecting broader cultural concerns with mental strain amid industrialization and . In , worry often symbolized inner turmoil or a ailment tied to nervous exhaustion, portrayed as a debilitating force that blurred the lines between moral weakness and physical disorder. Medical texts of the era increasingly associated worry with nervous disorders such as , a condition diagnosed by George Miller Beard in 1869 as involving fatigue, irritability, and anxious apprehensions resulting from modern life's demands on the . Figures like exemplified this view in personal accounts, describing worry as a chronic, debilitating affliction that exacerbated his physical symptoms, including and gastrointestinal distress, which he attributed to inherited nervous vulnerability and incessant mental fretting over health and legacy. In pre-20th-century discourse, worry was thus frequently framed as both a failing—stemming from insufficient —and a bodily ailment, amenable to rest cures or lifestyle reforms rather than deeper psychological intervention. The transition to modern psychology in the early 20th century reframed worry within psychoanalytic frameworks, where Sigmund Freud conceptualized it as a form of anxiety arising from repressed libidinal tensions or unconscious conflicts, often manifesting as transformed sexual energy rather than mere physical strangulation of the past. Freud's 1895 separation of "anxiety neurosis" from neurasthenia underscored worry's role in signaling ego threats, marking its evolution from somatic symptom to a key element of intrapsychic dynamics. Worry is primarily a cognitive process characterized by future-oriented chains of thoughts and images about potential negative events and outcomes, distinguishing it from , which serves as an immediate, alarm-like response to a perceived present or imminent , often accompanied by fight-or-flight physiological . In contrast, anxiety encompasses a broader, more pervasive emotional state that includes worry as its cognitive component but also features heightened physiological , such as increased and tension, directed toward anticipated dangers. This cognitive emphasis in worry aligns with Borkovec's avoidance theory, which posits it as a verbal-linguistic to suppress deeper emotional processing of uncertain future , thereby providing a temporary sense of . A key distinction exists between worry and rumination, another form of repetitive negative thinking; worry is predominantly future-directed and problem-focused, involving verbal rehearsals of potential solutions to hypothetical scenarios, whereas rumination is past-oriented, self-referential, and centered on causes, meanings, and consequences of negative experiences, often exacerbating depressive symptoms. Empirical studies, including one showing worry as a stronger predictor of both anxiety and symptoms than rumination, underscore their divergent emotional correlates despite shared repetitive qualities. In clinical contexts, excessive worry defines (GAD) according to criteria from the , requiring apprehensive expectation about multiple domains (e.g., work, health) occurring more days than not for at least six months, accompanied by symptoms like restlessness and difficulty concentrating. This pervasive, unfocused worry differentiates GAD from , where the core feature is recurrent, unexpected panic attacks—abrupt episodes of intense fear peaking within minutes, often with physical symptoms like —without the chronic anticipatory central to GAD. Similarly, specific phobias involve marked, disproportionate fear or anxiety triggered by a particular object or situation (e.g., animals, blood), leading to immediate avoidance, unlike the diffuse, future-oriented worry in GAD. Evolutionarily, worry functions as an adaptive mechanism for episodic foresight, allowing individuals to mentally simulate future threats and rehearse responses, which conferred survival advantages by promoting preparedness in uncertain ancestral environments. However, in contemporary settings, this foresight can become maladaptive when it escalates into chronic over-preparation, contributing to as a byproduct of normally beneficial vigilance systems.

Psychological Theories

Cognitive Models

Cognitive models of worry emphasize the role of thought processes in generating and maintaining this , viewing it as a product of biased information processing, evaluation, and metacognitive strategies rather than mere emotional reactivity. These frameworks, developed primarily in the late , highlight how worry emerges from selective to potential dangers and appraisals that amplify perceived risks while downplaying abilities. Key contributions include explanations of worry's verbal nature, its function in avoiding deeper emotional engagement, and beliefs that sustain it as adaptive. One influential model is Thomas Borkovec's cognitive avoidance theory, which posits that worry serves as a to suppress distressing mental and associated emotional . According to this view, worry predominantly involves verbal-linguistic rumination on abstract future threats, which inhibits the formation of vivid, sensory-based images that could trigger intense somatic responses like increased . This avoidance is negatively reinforced because it temporarily reduces anxiety by precluding full emotional processing of feared outcomes, thereby maintaining pathological worry over time. Borkovec et al. (2004) elaborate that this mechanism explains why individuals with (GAD) report using worry to distract from emotional topics, as the abstract, non- focus mutes physiological reactivity compared to relaxation or direct confrontation with threats. Richard Lazarus's appraisal theory provides another foundational cognitive perspective, framing worry as arising from the evaluation of in relation to personal . In primary appraisal, an or potential outcome is assessed as threatening or harmful, often involving uncertainty about future dangers, which initiates worry as a precautionary response. Secondary appraisal follows, where individuals gauge their coping resources and options; perceived inadequacy in handling the threat—such as low control or insufficient support—intensifies worry by heightening feelings of . Empirical evidence supports this in GAD contexts, where biased appraisals (overestimating threats and underestimating coping potential) predict higher worry frequency and contribute to disorder risk, as shown in large-scale surveys linking these patterns to stable negative dispositions. Lazarus (1991) originally outlined this two-stage process as central to and , with applications to worry underscoring how cognitive interpretations transform neutral uncertainties into persistent concerns. Attentional bias represents a core cognitive mechanism in worry, characterized by heightened sensitivity to and difficulty disengaging from threat-related information in the environment. This bias leads individuals to selectively allocate cognitive resources toward potential dangers, perpetuating a cycle of apprehension. Studies using the emotional Stroop task, a modified version of the classic color-naming interference paradigm, demonstrate this effect: participants with high worry or GAD exhibit slower response times when naming the ink color of threat words (e.g., "danger" or "failure") compared to neutral words, indicating interference from automatic threat detection. For instance, in older adults with pathological worry levels, color-naming latencies were significantly prolonged for negative stimuli (bias score ≈27 ms), mirroring patterns in younger GAD samples and contrasting with non-worriers who show reduced interference. Similarly, meta-analyses of Stroop studies in GAD confirm robust attentional capture by external threats, with delays in disengagement contributing to sustained worry independent of depressive biases. Adrian Wells and Gerald Matthews's metacognitive model further elucidates worry through beliefs about thinking itself, proposing that positive metacognitions drive its persistence. Developed in the 1990s, this framework argues that individuals endorse views of worry as beneficial, such as a strategy for thorough problem-solving or mental to prepare for worst-case scenarios, which motivates continued despite its costs. These beliefs, assessed via tools like the Meta-Cognitions , correlate with pathological worry in GAD, where worry is appraised as a form of proactive that enhances readiness. Wells and Matthews (1994) integrated this into a broader self-regulatory function model, emphasizing how such positive appraisals activate and prolong worry cycles, distinguishing it from mere content-focused rumination.

Avoidance and Uncertainty Models

The intolerance of uncertainty (IU) model posits that excessive worry in generalized anxiety disorder (GAD) arises primarily from a dispositional aversion to ambiguous future events, where uncertainty is appraised as threatening and uncontrollable, prompting worry as a maladaptive coping strategy to gain perceived predictability. Core features include heightened prospective anxiety about potential negative outcomes and behavioral avoidance of situations involving risk or ambiguity, which perpetuate the cycle by reinforcing the belief that uncertainty must be eliminated. This model, originally proposed by Dugas and colleagues, distinguishes IU as a transdiagnostic factor but emphasizes its centrality in GAD, where individuals engage in worry to mentally rehearse and neutralize uncertain threats. Within the () framework developed by Hayes, experiential avoidance refers to attempts to suppress or escape distressing internal experiences, such as or thoughts, which in the context of worry manifests as repetitive mental rumination to sidestep direct emotional confrontation and maintain psychological distance from anxiety. This avoidance sustains anxiety cycles by paradoxically amplifying worry over time, as individuals fuse with worry content to evade underlying affective experiences, leading to chronic emotional suppression rather than and value-driven . Empirical evidence supports these models through strong positive correlations between IU measures, such as the Intolerance of Uncertainty Scale, and GAD symptom severity, including worry frequency and intensity, observed across clinical and non-clinical samples. Interventions targeting IU, like uncertainty exposure training within , have demonstrated reductions in worry by enhancing tolerance for ambiguity, with meta-analyses indicating moderate to large effect sizes on GAD symptoms post-treatment. Similarly, ACT-based approaches reducing experiential avoidance have shown mediation effects, where decreased avoidance predicts lower worry levels in GAD patients. Behaviorally, worry functions as a form of avoidance that postpones emotional processing and confrontation with feared outcomes, thereby contributing to the chronicity of anxiety as evidenced in behavior therapy research examining physiological and cognitive suppression during worry episodes. This postponement creates a self-perpetuating , where short-term relief from immediate distress reinforces worry as a habitual response, hindering adaptive problem-solving and to .

Metacognitive and Evolutionary Perspectives

The metacognitive model of worry, developed by Adrian Wells, emphasizes that pathological worry arises not primarily from the intrusive thoughts themselves but from metacognitive beliefs—individuals' appraisals and knowledge about their own cognitive processes, particularly worrying. According to this framework, positive metacognitive beliefs portray worry as beneficial, such as a form of mental preparation or problem-solving strategy that anticipates and mitigates future threats, thereby motivating continued engagement in the process. In contrast, negative metacognitive beliefs frame worry as uncontrollable, harmful, and dangerous, leading to meta-worry (worry about worrying itself) and reinforcing a self-perpetuating cycle of cognitive activation. These beliefs are central to the model's explanation of , where appraisals of worry thoughts as uncontrollable and posing personal danger sustain the disorder by inhibiting disengagement and promoting avoidance of emotional processing. The Metacognitions Questionnaire-30 (MCQ-30), a validated 30-item scale derived from Wells's model, assesses these dimensions across five subscales, including uncontrollability and danger (e.g., beliefs that worry signals mental instability or physical harm) and cognitive confidence (e.g., doubts about one's thinking reliability). Empirical studies confirm the MCQ-30's (Cronbach's α > 0.70 for most subscales) and test-retest reliability (r > 0.75 over 5 weeks), with higher scores correlating strongly with worry severity in clinical populations. This measurement tool has facilitated research demonstrating that targeting these metacognitive appraisals, rather than thought content, disrupts worry cycles more effectively than traditional . From an evolutionary standpoint, worry is conceptualized as an adaptive shaped by to enhance through threat simulation and anticipatory planning in ancestral environments rife with unpredictable dangers. Drawing on principles of outlined by Tooby and Cosmides, worry aligns with , which posits that cognitive mechanisms evolved to bias toward over-detection of threats (false alarms) rather than under-detection (missed alarms), as the fitness costs of the latter were asymmetrically higher in hunter-gatherer contexts. This system facilitated proactive problem-solving and for potential hazards, such as predator encounters or social conflicts, by mentally rehearsing scenarios and generating coping strategies. However, in contemporary low-threat settings, this "fossilized alarm response"—a conserved mechanism from human evolutionary history—often misfires, transforming an once-adaptive vigilance into chronic, maladaptive rumination disconnected from real dangers. Recent research since 2010 has integrated metacognitive and evolutionary perspectives by examining how interventions cultivate metacognitive awareness, thereby interrupting worry cycles rooted in evolved threat biases. For instance, -based programs reduce negative metacognitive beliefs about uncontrollability and danger, leading to decreased physiological arousal (e.g., lower ) and self-reported worry in high-worriers, as these practices promote observation of thoughts akin to disengaging an overactive alarm system. A 2025 study further evidenced that changes in metacognitive beliefs mediate symptom reductions in anxiety following training, indicating moderate clinical impact and supporting the model's emphasis on meta-level regulation over content-focused change. This convergence highlights how enhancing awareness of worry's evolutionary origins can normalize it as a vestigial response, fostering adaptive in modern contexts.

Philosophical Perspectives

Ancient Views

In , worry and related states of were conceptualized within the humoral theory, which posited that health depended on the balance of four bodily fluids: blood, phlegm, yellow bile, and black bile. An excess of black bile was believed to cause , manifesting as persistent sadness, anxiety, or despondency, as described in Hippocratic texts such as Aphorisms and On the of , where emotional disturbances were seen as physiological imbalances requiring dietary and adjustments to restore . Aristotle, in his Nicomachean Ethics, linked worry to akrasia (weakness of will), portraying it as an excess of emotion—such as fear or apprehension—that disrupts rational judgment and prevents the pursuit of eudaimonia (flourishing or happiness). He argued that the virtuous person maintains emotional moderation to align actions with knowledge of the good, whereas akrasia occurs when passions override reason, leading to self-defeating behaviors akin to worrying over uncertainties rather than focusing on controllable virtues (Book VII). Stoic philosophers further developed these ideas, viewing worry as a futile preoccupation with uncontrollable externals. , in his , introduced the dichotomy of control, stating: "Some things are up to us and some things are not up to us," advising that worry arises from mistaking externals like health or reputation for internals like judgment and intention, and thus should be dismissed to achieve tranquility (Chapter 1). Similarly, , in Letters to Lucilius, described anxiety as suffering in anticipation, writing in Letter 13: "We suffer more often in imagination than in reality," urging focus on the present to counteract groundless fears about the future. In Eastern thought, early Buddhist texts in the Pali Canon framed worry as a form of dukkha (suffering or unsatisfactoriness) stemming from attachment (upādāna) to impermanent phenomena. The Dhammacakkappavattana Sutta (SN 56.11) identifies craving and clinging as the origin of dukkha, including mental afflictions like anxiety over loss or change, which can only be alleviated through detachment and the Noble Eightfold Path. Confucian philosophy, as recorded in the Analects, cautioned against excessive worry as a disruptor of social harmony (he), with Confucius advising: "Do not worry about lack of position; worry about becoming worthy of it" (4.14), emphasizing self-cultivation over fretting about external recognition to maintain inner and communal balance.

Modern and Existential Interpretations

In the 19th century, Søren Kierkegaard introduced a profound existential interpretation of worry as a form of dread or angst, arising from humanity's radical freedom and the infinite possibilities of choice. In The Concept of Anxiety (1844), he describes anxiety not as fear of a specific object but as the "dizziness of freedom," a vertiginous awareness of one's responsibility to actualize the self amid boundless potential, which can manifest as paralyzing worry over moral and spiritual decisions. This ontological dread, for Kierkegaard, is essential to the human condition, marking the leap toward authentic faith and selfhood, rather than mere psychological distress. Friedrich extended this critique by viewing worry as a symptom of "slave ," a reactive and resentful mindset that stifles the affirmative "" through excessive concern for security, pity, and conformity. In works like (1887), he contrasts this with master morality's noble indifference to petty anxieties, arguing that slave morality inverts values to valorize weakness and worry as virtues, thereby inhibiting life's creative overflow. To confront such inhibitions, proposed the of eternal recurrence in (1883–1885), urging individuals to embrace their existence without regret or anticipatory worry, as if every moment would repeat infinitely, thus transforming into joyful affirmation. In the 20th century, and reframed worry within as an anguished response to the universe's inherent meaninglessness, where human quests for purpose clash with indifferent reality. Sartre, in (1943), posits that worry stems from the of absolute freedom, leading individuals to evade responsibility through "bad faith"—inauthentic pretenses that disguise existential worry as external fate or social role, such as the waiter who over-identifies with his profession to avoid the dread of self-creation. Camus, in (1942), portrays worry as the initial revolt against the absurd, but advocates lucid acceptance and defiant living—through art, love, or rebellion—rather than or escapist illusions, emphasizing that authentic demands confronting meaninglessness without succumbing to paralyzing concern. Contemporary existential philosophy, particularly Martin Heidegger's (1927), interprets worry as inherent to "care" (Sorge), the fundamental structure of human existence (), encompassing "" into a world not of one's choosing and the anticipatory anxiety of finitude. Heidegger describes Sorge as an ontological worry over being-toward-death, where everyday distractions (fallenness) mask this primordial concern, yet authentic resoluteness emerges by owning one's thrown project amid uncertainty. Complementing this, Simone de Beauvoir's in (1949) critiques gendered worry as a social imposition, where women are conditioned into immanent roles of domestic vigilance and self-effacing concern, perpetuating and limiting ; she calls for women to transcend these anxieties through economic and mutual , reclaiming from patriarchal scripts.

Religious and Cultural Dimensions

Abrahamic Traditions

In Abrahamic traditions, worry is often interpreted as a spiritual affliction arising from insufficient trust in divine providence, with theological responses emphasizing reliance on God to restore inner peace. In Judaism, the Hebrew Bible portrays worry as an "anxiety of heart" that afflicts those who stray from covenantal obedience, as seen in Deuteronomy 28:65, where it is described as a consequence of exile and disobedience, manifesting as restless fear and dread among the people. This anxiety is balanced by calls to trust in God, exemplified in Deuteronomy 31:6, which urges Israel to "be strong and courageous" because "the Lord your God goes with you; he will never leave you nor forsake you," framing divine presence as the antidote to human trepidation. Talmudic literature further nuances this by permitting limited worry as a catalyst for repentance, particularly in discussions of teshuvah (return to God), where mild concern over past sins motivates ethical self-examination without descending into despair; for instance, the Babylonian Talmud in Yoma 86b stresses that genuine remorse, akin to constructive worry, facilitates atonement, distinguishing it from paralyzing fear. Christian theology similarly views worry as indicative of faltering , most prominently in the New Testament's , where instructs in :25-34, "Therefore I tell you, do not worry about your life, what you will eat or drink; or about your body, what you will wear," portraying it as unnecessary given God's provision for creation, like and lilies, and urging seekers to prioritize the kingdom of God instead. Early Puritan thinkers, such as , reframed certain forms of worry as "providential" when they prompt reliance on God's sovereignty, advising believers to meditate on divine oversight to alleviate anxiety, in contrast to unchecked fretting that undermines assurance of salvation. In modern evangelical contexts, this evolves into paradigms that integrate biblical exhortations with practical faith exercises, as in resources from , which counsel replacing worry with theological reflection on God's control to foster resilience against daily concerns. Islamic teachings counter worry through , or complete reliance on , as articulated in 65:3: "And whoever relies upon —then He is sufficient for him," presenting trust in divine decree as a remedy that dispels anxiety over worldly affairs. Hadiths reinforce this by warning against excessive concern for material matters as a whisper (waswas) from Shaytan, the , who seeks to erode ; for example, a narration in describes Shaytan's tactics in instilling doubts and fears to divert believers from submission to , urging instead steadfast and remembrance of to neutralize such influences. Medieval scholasticism, particularly in the works of , classifies inordinate fear (including excessive worry) as a when it pertains to temporal matters and causes contraction in the mind, preventing the performance of duties without fully severing charity toward God, as explored in the (II-II, q. 125) on fear. Aquinas ties such disorders to the broader effects of , which incline the will toward inordinate attachments that can manifest as anxious preoccupations with temporal security rather than eternal .

Eastern Philosophies and Religions

In Hinduism, worry, referred to as chinta, arises from entanglement in maya—the illusory nature of the material world—and the binding effects of karma, which perpetuate cycles of desire and suffering. The Bhagavad Gita, a foundational text, addresses this in Chapter 18 by emphasizing equanimity (samatva) as a means to transcend such mental agitation; Lord Krishna instructs Arjuna to perform actions without attachment to outcomes, integrating bhakti yoga (devotional surrender) and karma yoga (selfless action) to cultivate inner balance and freedom from anxiety over results. In , particularly within traditions, worry manifests as vicikiccha ( or skeptical uncertainty), identified as one of the five hindrances (nivarana) that obstruct meditative concentration and . texts, such as the , link this hindrance to tanha (craving or thirst), where obsessive attachment to future possibilities fuels restlessness and prevents clear seeing; it is resolved through vipassana ( meditation), which systematically dismantles by fostering direct awareness of impermanence (anicca), (dukkha), and non-self (anatta). Taoism views worry as a symptom of disharmony with the Dao (the natural way), stemming from excessive striving and interference with life's spontaneous flow, as articulated in Laozi's Tao Te Ching. The principle of wu wei (effortless non-action) serves as a countermeasure, encouraging alignment with the Dao through non-coercive responsiveness rather than forceful control over outcomes, thereby dissolving anxiety born of resistance. Ancient texts like the further illuminate these perspectives by promoting the realization of unity between (individual ) and (), which diminishes future-oriented worry by revealing the illusory separation of from the eternal whole. In Zen Buddhism, a later development influenced by these traditions, koans—paradoxical anecdotes or questions—confront worry indirectly by shattering dualistic thought patterns, inviting practitioners to embrace ambiguity and transcend anxious projections through intuitive insight beyond rational analysis.

Cross-Cultural Variations

In collectivist societies, such as those in , worry frequently revolves around maintaining social harmony and avoiding offense to others, reflecting cultural emphases on interdependence and group cohesion. For instance, in , taijin kyofusho represents a culturally specific manifestation of , characterized by intense fears that one's body, odor, or bodily functions might disgust or embarrass others, leading to heightened interpersonal worry. This contrasts with individualist Western cultures, where worry more often centers on personal achievement, , and individual failure, as and are prioritized in psychological . Cross-cultural studies indicate that these differences contribute to higher reported in collectivist contexts, while Western individuals may experience elevated worry tied to personal goals and independence. Among Indigenous populations, such as Native American communities, worry and anxiety are often conceptualized as disruptions in holistic between , , , and , stemming from disconnection from the natural world or ancestral traditions. Resolution typically involves traditional healing practices and time spent in nature to restore harmony and spiritual alignment, viewing these as essential for emotional equilibrium rather than isolated psychological symptoms. In African contexts, the promotes communal sharing of worries as a core mechanism for emotional support, emphasizing that individual well-being is intertwined with the collective, where burdens like anxiety are collectively borne through and mutual care within the community. This approach fosters by redistributing personal distress across social networks, aligning with cultural values of interconnected humanity. Gender differences in worry appear consistently across cultures, with women reporting higher levels globally, often linked to societal roles and expectations. World Health Organization-affiliated research highlights that women are approximately 1.5 to 2 times more likely to experience anxiety disorders, including excessive worry, than men, a pattern observed in diverse settings from high-income to low-income countries. Socioeconomic factors further amplify worry in developing regions, where economic instability—such as and —exacerbates anxiety through and resource scarcity, with individuals in low-income groups facing 1.5 to 3 times higher risks of compared to higher-income counterparts. In these areas, financial insecurity intensifies worry about , contributing to broader psychological strain. Globalization has introduced hybrid forms of worry influenced by , blending local cultural concerns with universal pressures like social comparison and , which heighten anxiety across borders. Studies from the 2020s, particularly during the , reveal cross-cultural spikes in worry, with global surveys showing elevated distress levels in 48 countries due to health uncertainties and , though expression varied by cultural norms—such as greater communal in collectivist societies versus individual health concerns in the West. These findings underscore how digital connectivity and shared global events create overlapping worry patterns while retaining cultural nuances.

Biological and Neurological Basis

Brain Structures and Pathways

Worry involves a distributed network of structures that detect threats, regulate emotional responses, and monitor for errors or uncertainties. The serves as a primary hub for threat detection, rapidly evaluating environmental cues for potential dangers and triggering affective responses that underpin the initial stages of worry. This structure receives sensory inputs via thalamic and cortical pathways, enabling quick appraisal of ambiguous or future-oriented threats. The , encompassing the (vmPFC) and (dlPFC), exerts top-down regulation over the , facilitating cognitive reappraisal and suppression of excessive worry through inhibitory projections. Additionally, the (ACC) plays a crucial role in error monitoring and conflict detection, heightening awareness of discrepancies between expectations and reality, which can perpetuate worry loops by amplifying perceived risks. Key neural pathways integrate these regions to sustain worry as a persistent state. The hypothalamic-pituitary-adrenal (HPA) axis links emotional processing to physiological stress responses, with worry-induced activation of the amygdala and prefrontal areas stimulating hypothalamic release of corticotropin-releasing hormone, culminating in cortisol secretion from the adrenal glands; this feedback reinforces vigilance but can dysregulate chronic worry. Concurrently, hyperactivity in the default mode network (DMN)—comprising the medial prefrontal cortex, posterior cingulate cortex, and angular gyrus—facilitates rumination, a repetitive focus on worries about potential future events, by promoting self-referential and prospective thinking during rest or low-demand states. These pathways highlight worry's integration of rapid threat signaling with prolonged cognitive elaboration. Functional neuroimaging provides evidence for altered connectivity in worry-prone individuals. (fMRI) studies reveal heightened amygdala-prefrontal connectivity during anticipation of uncertain threats, such as in tasks involving unpredictable negative outcomes, correlating with self-reported worry levels in healthy and anxious participants. This increased coupling reflects an adaptive bias toward threat vigilance but becomes maladaptive in excessive worry, with stronger dorsomedial prefrontal-amygdala interactions predicting anticipatory anxiety. Developmentally, worry circuits undergo significant maturation during , a period of heightened vulnerability due to ongoing refinement of corticolimbic connections. The , critical for , shows delayed structural and functional development relative to the , leading to imbalances that amplify emotional reactivity and worry in teens. Genetic factors influence this trajectory; variants in the COMT gene, particularly the Val158Met polymorphism, modulate signaling in prefrontal regions, with the Met allele (associated with "worrier" profiles) linked to enhanced stress reactivity and altered circuit efficiency in adolescents under pressure. Recent research as of 2025 has also implicated , brain immune cells, in anxiety , with specific microglial populations (non-Hoxb8) promoting heightened anxiety levels by influencing neural circuits.

Neurochemical Influences

Worry, as a core feature of (GAD) and related conditions, is modulated by several key systems, including serotonin, the /glutamate balance, the hypothalamic-pituitary-adrenal () axis involving , and . These systems influence the intensity and persistence of worry through interactions with brain circuits, such as those involving the and . Serotonin plays a critical role in regulating emotional responses, with low levels associated with heightened worry and anxiety. Specifically, reduced activity at 5-HT1A receptors, which are inhibitory autoreceptors and postsynaptic sites, contributes to diminished tone, leading to increased reactivity and impaired top-down control from the . Selective serotonin reuptake inhibitors (SSRIs), by blocking serotonin reuptake, elevate extracellular serotonin levels, which desensitizes presynaptic 5-HT1A autoreceptors over time and enhances postsynaptic signaling. This mechanism strengthens prefrontal inhibition over limbic regions, thereby reducing pathological worry. The balance between gamma-aminobutyric acid (), the primary inhibitory , and glutamate, the main excitatory one, is essential for preventing excessive neural activation underlying worry. Deficient inhibition relative to glutamatergic excitation creates excitatory loops that sustain ruminative thoughts and characteristic of worry. Benzodiazepines, acting as positive allosteric modulators at GABA_A receptors, enhance binding and chloride influx, temporarily dampening these excitatory circuits and alleviating acute worry symptoms. Chronic worry activates the axis, resulting in sustained elevation that sensitizes noradrenergic systems, promoting heightened vigilance and arousal. In individuals with GAD, studies reveal altered diurnal patterns, including elevated morning levels and a flattened , which correlate with persistent worry and impaired stress recovery. This hypercortisolemia enhances norepinephrine release from the , amplifying noradrenergic signaling in vigilance networks and perpetuating a state of anticipatory anxiety. Dopamine contributes to worry through its involvement in processing reward , where ambiguous outcomes trigger persistent evaluation and rumination. Dysregulation in , particularly in the mesolimbic system, can fuel worry by heightening sensitivity to potential negative rewards. Genetic polymorphisms in the D4 receptor (DRD4), such as the 7-repeat in exon III, have been linked to context-dependent anxiety biases and altered stress reactivity.

Health and Societal Impacts

Mental Health Consequences

Excessive worry serves as a core diagnostic criterion for (GAD), defined in the as apprehensive expectation occurring more days than not for at least six months, accompanied by difficulty controlling the worry and associated with symptoms such as restlessness or . This pervasive feature distinguishes GAD from normal anxiety and contributes to its high comorbidity with other psychiatric conditions, notably , where meta-analyses from national surveys indicate that approximately 58% of individuals with 12-month GAD also meet criteria for major depression. Such overlap exacerbates symptom severity and functional impairment, as worry reinforces negative cognitive patterns shared between the disorders. Worry also plays a significant role in obsessive-compulsive disorder (OCD), where it functions as a maladaptive thought that interacts with obsessive beliefs to predict increased intrusive thoughts and subsequent ritualistic behaviors. In posttraumatic stress disorder (PTSD), hypervigilant worry mediates the link between attentional biases toward threats and core symptoms like re-experiencing, amplifying the involuntary recall of traumatic events through sustained anticipatory anxiety. These connections highlight worry's transdiagnostic influence, positioning it as a predictor of symptom persistence across anxiety-related pathologies. Over time, chronic worry contributes to broader deterioration, including , where repetitive negative thinking, such as pre-sleep rumination, directly associates with elevated next-day emotional exhaustion. It frequently disrupts , with 60-70% of individuals with GAD reporting significant due to persistent . Furthermore, even mild worry symptoms in healthy older adults predict declines in learning and over two years, suggesting a pathway to independent of diagnosed disorders. Epidemiologically, the lifetime prevalence of problematic worry, as manifested in GAD, ranges from 5-10% globally, reflecting its status as a common yet burdensome condition. Post-2020 studies, particularly amid the , indicate higher rates in settings, where anxiety symptoms, including excessive worry, were more severe than in rural areas due to intensified stressors like and resource constraints.

Physical Health Effects

Chronic worry activates the hypothalamic-pituitary-adrenal (HPA) axis, leading to sustained elevations in such as , which can contribute to increased and heightened cardiovascular risk. Longitudinal studies have shown that individuals with high levels of worry experience steeper trajectories in systolic and diastolic , with high deportation-related worry associated with a 2.17-fold increased for incident over five years. In the Normative Aging Study, prospective data linked worry to elevated risk of coronary heart disease, with anxiety components including worry contributing to a 60% excess risk of CHD independent of traditional factors like or . Elevated from chronic suppresses immune function by inhibiting production and impairing T-cell activity, resulting in higher susceptibility to infections and delayed . Research on caregivers, who often experience repetitive worry as a form of , demonstrates reduced efficacy and increased reactivation of latent viruses due to this . In older adults, sustained exposure from stress-related worry promotes immune resistance to glucocorticoids, exacerbating and weakening overall immune responsiveness. Worry correlates with gastrointestinal disorders through dysregulation of the gut-brain axis, where heightened anxiety amplifies visceral hypersensitivity and alters gut motility. Studies indicate that individuals with (IBS) exhibit elevated trait anxiety and worry, with genetic overlaps (e.g., in genes like CADM2) between IBS and anxiety disorders supporting a bidirectional link. This axis disruption contributes to symptoms like and altered bowel habits, with up to 4.27 for co-occurring anxiety in IBS patients. Ulcer development is similarly promoted via stress-induced mucosal damage and reduced protective factors in the stomach lining. Recent 2020s research highlights chronic worry's role in accelerated biological aging, including shortening, where high perceived equates to 9–17 years of additional cellular aging through oxidative damage and reduced activity. Worry and related anxiety are associated with (MetS), with meta-analyses showing a 7% increased of MetS in anxious individuals and vice versa, mediated by and HPA dysregulation. These findings underscore worry's contribution to broader physiological wear, overlapping briefly with risks like but manifesting distinctly in somatic changes.

Societal and Economic Ramifications

Worry, as a component of anxiety disorders, significantly impacts productivity and leads to substantial economic losses through and . Globally, and anxiety, which often manifest as worry, result in the loss of approximately 12 billion working days annually, costing the nearly US$1 trillion in lost each year. This figure encompasses reduced among affected workers who continue to show up but perform at lower capacity due to persistent worry, with studies highlighting that untreated conditions like anxiety amplify these effects in high-stress professional environments. On a societal level, collective worry intensifies during crises, fostering widespread emotional strain that affects community cohesion and youth well-being. For instance, in the , surveys of young people have revealed high levels of climate-related anxiety, with 59% of respondents aged 16-24 across 10 countries reporting they were very or extremely worried about , contributing to broader social disconnection and reduced . Such collective worry can exacerbate intergenerational tensions, as younger populations grapple with future-oriented fears that influence social interactions and . Public health policies have increasingly addressed worry through targeted campaigns, particularly during pandemics, while economic models demonstrate its influence on consumer patterns. During the outbreak, the World Health Organization's #HealthyAtHome initiative provided resources to manage pandemic-induced worry and , aiming to mitigate its spread through accessible guidance. Economically, models show that heightened anxiety drives behaviors like , as seen in early 2020 when consumer of essentials was linked to of and , disrupting supply chains and inflating short-term costs. Media further amplifies societal worry by promoting negative content, with — the compulsive consumption of distressing online — playing a key role in elevating anxiety levels. Research indicates that correlates with increased existential anxiety and , as users repeatedly engage with alarming headlines that reinforce a of worry. Studies on algorithms reveal how negative spreads virally, intensifying collective unease and contributing to broader burdens during uncertain times.

Management and Interventions

Self-Management Techniques

Mindfulness and meditation practices offer accessible self-management strategies for addressing worry by promoting non-judgmental awareness of anxious thoughts. Developed by , (MBSR) is an eight-week program incorporating meditation, body awareness, and gentle to help individuals observe worries without becoming entangled in them. Randomized controlled trials (RCTs) have demonstrated that MBSR significantly reduces anxiety symptoms, including pathological worry, in individuals with , with meta-analyses indicating moderate effect sizes (Hedges' g ≈ 0.5) corresponding to approximately 20-30% symptom reduction compared to control groups. Journaling and structured "worry time" provide cognitive tools to contain and process worries, drawing from principles without requiring professional guidance. In this approach, individuals schedule a dedicated 15-30 minute period daily to write down worries, distinguishing between those amenable to problem-solving (e.g., actionable steps like preparing for a deadline) and those requiring (e.g., uncontrollable events like past regrets). Evidence from studies on shows it effectively reduces the and of intrusive worries by postponing rumination, with one reporting significant decreases in subjective health complaints related to anxiety. A of techniques for pathological worry confirms large effect sizes (Cohen's d = 1.81) in symptom reduction versus no-treatment controls. Lifestyle modifications further support worry management by influencing physiological stress responses. Regular , such as brisk walking or for 30 minutes most days, lowers levels—a key linked to heightened worry—with one study finding a 20% reduction in serum cortisol following aerobic sessions. Sleep hygiene practices, including maintaining consistent bedtimes, creating a dark and cool sleep environment, and avoiding screens before bed, improve sleep quality and thereby mitigate anxiety, as poor sleep exacerbates worry cycles; interventions enhancing have shown medium-sized effects on outcomes like reduced anxiety. Dietary intake of omega-3 fatty acids, found in foods like fatty fish or supplements, modulates to alleviate anxiety symptoms, with RCTs demonstrating a 20% reduction in self-reported anxiety alongside decreased inflammatory markers. In the , digital tools have emerged as convenient self-management aids for worry. Apps like Worry Watch enable users to log worries, track patterns, and apply -inspired postponement during designated sessions, fostering greater . Preliminary evidence from studies on similar low-intensity apps indicates high engagement and significant reductions in worry symptoms, with one trial showing decreased anxiety after four weeks of use via and features.

Clinical Treatments and Therapies

Cognitive-behavioral therapy () represents a cornerstone treatment for pathological worry, particularly in (GAD), where it targets core processes such as excessive worry through techniques like worry exposure and . Worry exposure involves imaginal or confrontation with feared worry scenarios to reduce avoidance and habitual rumination, while challenges catastrophic predictions and overestimation of threat. These protocols draw from influential cognitive models adapted for anxiety, emphasizing the modification of maladaptive beliefs about worry. Meta-analyses of randomized controlled trials demonstrate that yields moderate to large effect sizes, with symptom reductions typically ranging from 50% to 60% on standardized anxiety measures compared to waitlist or control conditions. Pharmacotherapy serves as a first-line option for managing pathological worry in GAD, with selective serotonin reuptake inhibitors (SSRIs) like recommended due to their efficacy in modulating serotonin pathways to alleviate anxiety symptoms. , at doses of 10-20 mg daily, has shown significant improvements in worry and overall anxiety severity in clinical trials, often achieving response rates of 50-60% within 8-12 weeks. Benzodiazepines, such as or , are reserved for acute symptom relief in GAD due to their rapid onset via enhancement, but chronic use is discouraged owing to risks of , dependence, and . Emerging therapies for pathological worry incorporate acceptance-based approaches, including (ACT) and (MBCT), which integrate and acceptance strategies to disrupt worry cycles without direct suppression. promotes psychological flexibility by encouraging value-aligned actions amid uncertainty, with meta-analyses indicating efficacy comparable to traditional for reducing GAD symptoms, achieving moderate effect sizes (Hedges' g ≈ 0.6-0.8). combines practices with cognitive elements to foster non-judgmental awareness of worry, demonstrating reductions in anxiety severity and improved long-term functioning in GAD patients. For treatment-resistant cases, (TMS) offers a non-invasive option, targeting prefrontal circuits implicated in worry regulation; while FDA-approved for since 2008, off-label use for anxiety has gained traction in the 2020s with accelerated protocols showing promise in reducing symptoms by 40-50% in resistant GAD. As of 2025, psychedelic-assisted therapies have emerged as a novel approach, with a single moderate dose of MM120 (a lysergide derivative) demonstrating significant and sustained reductions in GAD symptoms—equivalent to five to six points on standardized anxiety scales—in a phase 2b RCT involving 198 adults, marking a potential first new pharmacological treatment in nearly 20 years. Additionally, models are being explored to personalize treatment selection for GAD by predicting recovery based on patient factors, enhancing outcomes in and as of early 2025. Efficacy data from large-scale trials underscore the long-term benefits of these interventions in preventing among individuals with pathological worry. The Coordinated Anxiety Learning and Management (CALM) study, a collaborative trial involving and , reported sustained symptom remission in 40-50% of GAD participants at 12-18 months post-treatment, with lower recurrence rates (around 30%) compared to usual . These outcomes highlight the role of integrated clinical approaches in maintaining gains, often augmented by self-management techniques for prevention.

References

  1. [1]
    Worry | Division of Cancer Control and Population Sciences (DCCPS)
    Worry has been conventionally defined as a chain of thoughts and images, which are negatively affect-laden and relatively uncontrollable.Missing: authoritative | Show results with:authoritative
  2. [2]
    What Is Worry? | Psychology Tools
    Worry has been defined as thinking about future events in a way that leaves individuals feeling anxious or apprehensive. Clinically, excessive worry is the ...Missing: authoritative | Show results with:authoritative
  3. [3]
    Why We Worry | Scientific American
    Nov 1, 2009 · Psychologists believe that worry, defined as a person's negative thoughts about a future event, evolved as a constructive problem-solving ...Missing: authoritative sources
  4. [4]
    Generalized Anxiety Disorder - National Institute of Mental Health
    An estimated 2.7% of U.S. adults had generalized anxiety disorder in the past year. Past year prevalence of generalized anxiety disorder among adults was higher ...Prevalence of Generalized... · Generalized Anxiety Disorder...
  5. [5]
    Worry | Fact Sheet - ABCT
    Worry is an anxious way of thinking about oneself and the world. It usually involves thoughts about what bad things might happen in the future.Missing: authoritative | Show results with:authoritative
  6. [6]
    The Cognitive Avoidance Theory of Worry. - APA PsycNet
    When we began experimental research on worry, we defined the process as "a chain of thoughts and images, negatively affect-laden and relatively ...
  7. [7]
    Worry: A Cognitive Phenomenon Intimately Linked to Affective ...
    Worry involves apredominance of verbal thought activity, functions as atype of cognitive avoidance, and inhibits emotionalprocessing.
  8. [8]
    The nature of worry in generalized anxiety disorder - PubMed - NIH
    Indirect evidence suggests that worry primarily involves thought, rather than imaginal, activity, a distinction within cognitive process.
  9. [9]
    Diagnosis and Management of Generalized Anxiety Disorder ... - AAFP
    May 1, 2015 · The hallmark of GAD is excessive, out-of-control worry, and PD is characterized by recurrent and unexpected panic attacks.
  10. [10]
    The history of generalized anxiety disorder as a diagnostic category
    The concept of worry puts the emphasis on the psychological symptomatology, specifically on the cognitive functioning. Thus, an anxious condition that, earlier, ...
  11. [11]
    A novel theory of experiential avoidance in generalized anxiety ...
    Borkovec's model of GAD (Borkovec, 1994; Borkovec et al., 2004) suggests that worry functions as a cognitive avoidance response to perceived future threats.
  12. [12]
    Worry - Etymology, Origin & Meaning
    Originating c. 1300 from Old English wyrgan, meaning "to strangle," worry evolved from the verb's sense of biting and shaking to mean "harassing anxiety ...
  13. [13]
  14. [14]
    No one in Shakespeare's Day ever worried? Showing 1-44 of 44
    Aug 17, 2015 · The word "worry" was only used in Shakespeare's entire cannon once. Once! And as a verb meaning "to choke," not even in the sense of to worry like we use it ...
  15. [15]
    Worrying: A Literary and Cultural History by Francis O'Gorman
    Jun 19, 2015 · According to the book's loose-fitting chronology, worrying, which at first referred solely to the act of choking or distressing animals or ...
  16. [16]
    Somatic Fictions | Stanford University Press
    This book explores how Victorian narrative registers fears of psychic and somatic permeability, sympathetic identification with another's pain, and conflicting ...
  17. [17]
    Neurasthenia and a Modernizing America - JAMA Network
    The emphasis in neurasthenia on nervous energy makes for a vague disease by today's standards, but it allowed physicians and patients in the late 19th century ...
  18. [18]
    Evolution and Angst: Charles Darwin Was a Worrier [Excerpt]
    Feb 11, 2016 · Darwin worried incessantly that he or his children had inherited a weak constitution from his mother's side of the family, and he knew from her ...
  19. [19]
    [PDF] Mental Illness, Narrative Voice, and Gender in Mid-Victorian Literature
    Jul 10, 2023 · Doctors and the public increasingly saw mental illness as a medical concern, not indications of a corrupt soul or a moral failing, though ...
  20. [20]
    Defense Mechanisms - StatPearls - NCBI Bookshelf - NIH
    May 22, 2023 · Sublimation: Transforming one's anxiety or emotions into pursuits considered by societal or cultural norms to be more useful. This defense ...Missing: worry | Show results with:worry
  21. [21]
    Death of neurasthenia and its psychological reincarnation
    Jan 2, 2018 · Abandonment of neurasthenia by neurology​​ For example, in 1895 Freud removed anxiety neurosis from neurasthenia (Reference Freud and ...
  22. [22]
    Anxiety - American Psychological Association
    Anxiety may be distinguished from fear both conceptually and physiologically, although the two terms are often used interchangeably. Anxiety is considered a ...
  23. [23]
    Do I have anxiety or worry: What's the difference? - Harvard Health
    Oct 27, 2020 · Worry is a component of anxiety symptoms. Anxiety ... You might notice feelings of fear and dread, two examples of the emotional component.
  24. [24]
    Is worry different from rumination? Yes, it is more predictive of ...
    Nov 5, 2009 · Worry was viewed as more negative than rumination and was more predictive of anxiety as well as of depression than rumination.
  25. [25]
    What are Anxiety Disorders? - American Psychiatric Association
    Generalized anxiety disorder involves persistent and excessive worry that interferes with daily activities. This ongoing worry and tension may be accompanied ...Types Of Anxiety Disorders · Panic Disorder · Diagnosis, Treatment And...
  26. [26]
    Episodic foresight and anxiety: Proximate and ultimate perspectives
    Mar 16, 2015 · In this paper, we examine the relationship between episodic foresight and anxiety from an evolutionary perspective, proposing that together they ...
  27. [27]
    Evolutionary aspects of anxiety disorders - PMC - PubMed Central
    Anxiety is a component of de-escalating strategies mediated by the paleomammalian and reptilian forebrains.
  28. [28]
    Generalized Anxiety Disorder: Bringing Cognitive-Behavioral ...
    Borkovec, T. D., Alcaine, O. M., & Behar, E. (2004). Avoidance Theory of Worry and Generalized Anxiety Disorder. In R. G. Heimberg, C. L. Turk, & D. S. ...
  29. [29]
    Appraisal Bias and Emotion Dispositions Are Risk Factors ... - Frontiers
    Appraisal theory of emotion predicts that appraisal biases may generate stable emotion dispositions, which can ultimately lead to affective disorders.
  30. [30]
    Emotional Stroop Performance in Older Adults: Effects of Habitual ...
    ... pathological levels of worry, leaving an attentional profile similar to that seen in younger adult GAD. Biased processing of emotional material may ...
  31. [31]
    Attentional Bias in Generalized Anxiety Disorder Versus Depressive ...
    This review evaluates evidence of attentional biases in generalized anxiety disorder (GAD) and depressive disorder from studies using modified Stroop and v.
  32. [32]
    Meta-Cognition and Worry: A Cognitive Model of Generalized ...
    Jun 16, 2009 · A meta-cognitive classification and analysis of factors contributing to the development of problematic worry is presented.
  33. [33]
    Generalized anxiety disorder: a preliminary test of a conceptual model
    This study presents a preliminary test of a conceptual model of Generalized Anxiety Disorder (GAD) which is theoretically driven and has clear clinical ...
  34. [34]
    A Cognitive Model of Generalized Anxiety Disorder - ResearchGate
    It is thought that generalized anxiety is initiated and maintained by intolerance of uncertainty (Koerner & Dugas, 2006)<|control11|><|separator|>
  35. [35]
    Reductions in experiential avoidance as a mediator of change in ...
    While efficacious CBTs have been developed for GAD, treatment response rates are lower than other anxiety disorders (Waters & Craske, 2005), highlighting the ...
  36. [36]
    Revising the Intolerance of Uncertainty Model of Generalized ...
    The Intolerance of Uncertainty Model (IUM) of Generalized Anxiety Disorder (GAD) attributes a key role to Intolerance of Uncertainty (IU), and additional roles ...Abstract · Introduction · Study 1 · General Discussion
  37. [37]
    The impact of psychological treatment on intolerance of uncertainty ...
    Research has demonstrated a strong link between intolerance of uncertainty and generalized anxiety disorder (GAD). The current systematic review and meta ...
  38. [38]
    [PDF] Borkovec Ray Stöber (1998) COTR.pdf - Kent Academic Repository
    The demonstrated suppressive effects of worry on somatic anxiety could also be due to the fact that worry uses up significant amounts of attentional resource ( ...
  39. [39]
    Avoidance Theory of Worry and Generalized Anxiety Disorder.
    The purpose of the present chapter is to review empirical literature relevant to the potential avoidance functions of worry; to describe the significant ...
  40. [40]
    A cognitive model of generalized anxiety disorder. - APA PsycNet
    These beliefs center on the themes of uncontrollability of worries and the dangerous consequences of worrying. Negative appraisal of worrying is associated ...
  41. [41]
    A short form of the metacognitions questionnaire - PubMed
    The MCQ-30 showed good internal consistency and convergent validity, and acceptable to good test-retest reliability. Positive relationships between ...
  42. [42]
    A short form of the metacognitions questionnaire - ScienceDirect.com
    The MCQ-30 is a brief multidimensional measure of metacognitions, that is more economical to use than the original MCQ.
  43. [43]
    [PDF] The Theoretical Foundations of Evolutionary Psychology
    THE THEORY OF evolution by natural selection has revolutionary implications for understanding the design of the human mind and brain, as Darwin himself was.
  44. [44]
    Treating chronic worry: Psychological and physiological effects of a ...
    These findings suggest that mindfulness reduces chronic worry by promoting emotional and physiological regulatory mechanisms contrary to those maintaining ...
  45. [45]
    Mechanics of Mindfulness: Investigating Metacognitive Beliefs as a ...
    Jun 12, 2025 · Changes in metacognitive beliefs are a potential pathway for MBI-driven reductions in anxiety and depression symptomology.
  46. [46]
    “And there's the humor of it” Shakespeare and The Four Humors - NIH
    Hippocrates also used the humors to explain moods and emotional states in physical terms. For example, when a patient was melancholic, the feelings of sadness ...Missing: worry | Show results with:worry
  47. [47]
    Aristotle's Ethics - Stanford Encyclopedia of Philosophy
    May 1, 2001 · Aristotle thinks everyone will agree that the terms “eudaimonia” (“happiness”) and “eu zên” (“living well”) designate such an end. The Greek ...Missing: worry | Show results with:worry
  48. [48]
    Letter 13: On Groundless Fears | Seneca Letters From a Stoic
    Jul 5, 2014 · No fear is so ruinous and so uncontrollable as panic fear. For other fears are groundless, but this fear is witless.
  49. [49]
    The Analects of Confucius
    The Master said: “Don't' worry if you have no position: worry about making yourself worthy of one. Don't' worry if you aren't known and admired: devote ...
  50. [50]
    Søren Kierkegaard - Stanford Encyclopedia of Philosophy
    May 22, 2023 · At the heart of this notion of choice is the view that freedom ... Translated as The Concept of Anxiety in Søren Kierkegaard, Jeanette B. L. Knox ...1. Life And Works · 3. The ``spheres Of... · 3.3 The Religious And The...Missing: dread | Show results with:dread<|control11|><|separator|>
  51. [51]
    Nietzsche's Moral and Political Philosophy
    Aug 26, 2004 · Nietzsche's moral philosophy is primarily critical in orientation: he attacks morality both for its commitment to untenable descriptive (metaphysical and ...
  52. [52]
    Existentialism - Stanford Encyclopedia of Philosophy
    Jan 6, 2023 · Like Kierkegaard, Heidegger interprets anxiety as an individualizing mood, one that momentarily “snatches one back” from the tranquilizing ...
  53. [53]
    Martin Heidegger - Stanford Encyclopedia of Philosophy
    Jan 31, 2025 · When overcome by anxiety, that mattering “collapses” and the affordances of the world show up as being “of no consequence” (SZ 186). In this ...Heidegger's Aesthetics · 108 · Heidegger and the Other... · Heidegger on Language
  54. [54]
    Simone de Beauvoir - Stanford Encyclopedia of Philosophy
    Aug 17, 2004 · Beauvoir's liberatory response to women's oppression is a feminism of freedom. The Second Sex argues against the either/or frame of the woman ...Missing: worry | Show results with:worry
  55. [55]
    Apply Providence to Alleviate Anxiety | Puritan Reformed Presbyterian
    We need to apply the knowledge of providence by meditation so that we personally bless our souls with rest from worry.
  56. [56]
    Anxiety and Worry - Ligonier Ministries
    In addressing anxiety, Jesus and the Apostles give believers numerous theological rationales and practical truths to help them overcome sinful fear.
  57. [57]
    Whispers from the Shaytaan - Islam Question & Answer
    May 17, 2010 · One of the means that the Shaytan uses to misguide people is by casting doubts and whispers (waswas) into their hearts.
  58. [58]
    SUMMA THEOLOGIAE: The effects of sin, and, first, of the corruption ...
    Whether weakness, ignorance, malice and concupiscence are suitably reckoned as the wounds of nature consequent upon sin? ... Thomas Aquinas Second and Revised ...
  59. [59]
    The Bhagavadgita on the Stability of Mind - Hindu Website
    According to Hinduism, the instability of the mind is designed by Nature or Prakriti as part of its Maya to keep the beings deluded and distracted so that they ...Missing: chinta worry
  60. [60]
    Chapter 18: Mokṣha Sanyās Yog - Bhagavad Gita, The Song of God
    Further in this chapter, Shree Krishna portrays in detail the attributes of those who have attained perfection in spirituality and realized the Brahman. He adds ...BG 18.63: Chapter 18, Verse 63 · BG 18.48: Chapter 18, Verse 48 · BG 18.18Missing: equanimity karma<|separator|>
  61. [61]
    The Five Mental Hindrances and Their Conquest - Access to Insight
    They are called "hindrances" because they hinder and envelop the mind in many ways, obstructing its development (bhavana). According to the Buddhist teachings, ...Missing: tanha | Show results with:tanha
  62. [62]
    [PDF] vicikiccha.pdf
    As a hindrance, vicikiccha can manifest in relation to internal as well as external phenomena (S. V. 110). Moreover, doubt could arise in regard to the past, ...
  63. [63]
    Taoist Wisdom for Letting Go of Anxiety | . - Tao Te Ching
    Like many Taoist teachings, wu wei offers practical tools for dealing with anxiety. By letting go of resistance, we conserve energy and become more ...
  64. [64]
    The spiritual philosophy of Advaita: Basic concepts and relevance to ...
    Feb 12, 2024 · The phrases in the Upanishads that proclaim the sameness of Atman and Brahman are called Mahavakyas (Great sayings). The two most famous ...
  65. [65]
    How to Practice Zen Koans | Lion's Roar
    You are joining a timeless conversation and you are forming a relationship with the koan, so you can let all that happen without worrying about it.
  66. [66]
    A Japanese form of social anxiety (taijin kyofusho) - PubMed
    Taijin kyofusho is characterized by an intense fear that one's body parts or functions displease, embarrass or are offensive to others.
  67. [67]
    Cultural differences in perceived social norms and social anxiety
    Collectivistic countries also reported greater levels of social anxiety and more fear of blushing than individualistic countries. Significant positive relations ...Missing: worry | Show results with:worry
  68. [68]
    Cultural Aspects in Social Anxiety and Social Anxiety Disorder - PMC
    Taijin kyofusho (TKS) has frequently been discussed as a culture-specific expression of SAD that is believed to be particularly prevalent in Japanese and Korean ...
  69. [69]
    Indigenous Native American Healing Traditions - PMC - NIH
    Native Americans in Arizona run each day to greet the dawn, a practice that not only conditions their bodies but also nourishes their spiritual wellbeing.
  70. [70]
    Indigenous Healing Practices for Anxiety & Depression
    The earth, trees, animals, and even the weather are seen as guides and protectors. Spending time in nature is a powerful way to reduce anxiety and depression.
  71. [71]
    Hunhu/Ubuntu in the Traditional Thought of Southern Africa
    Thus, Hunhu/Ubuntu, as an aspect of African philosophy, prides in the idea that the benefits and burdens of the community must be shared in such a way that no ...Missing: worry | Show results with:worry
  72. [72]
    Evaluating effects of community-based social healing model ... - NIH
    The CBSH model aligns with Ubuntu African philosophy, which fosters individual wellbeing within a collective environment, supportive relationships, personal and ...Missing: worries | Show results with:worries
  73. [73]
    Gender differences in worry and associated cognitive-behavioral ...
    Women reported more worry than men on two measures of the tendency to worry, as well as more worries about lack of confidence issues. Women also reported a more ...
  74. [74]
    Gender Differences in Anxiety Disorders: Prevalence, Course ... - NIH
    Overall, the lifetime and past year rates were approximately 1.5 to 2 times as common among women, with the greatest differences in PTSD, GAD, and PD. The ...
  75. [75]
    Poverty, depression, and anxiety: Causal evidence and mechanisms
    Those with the lowest incomes are typically 1.5 to 3 times more likely than the rich to experience depression or anxiety.
  76. [76]
    [PDF] Poverty and common mental disorders in developing countries - IRIS
    One study showed a higher risk for disorders in persons in the upper income group if they lived in unequal areas (27). Insecurity. Poor people stress the ...<|separator|>
  77. [77]
    Unraveling the Cross-Cultural Differences in Online Expression of ...
    Mar 25, 2024 · In this study, we examine the cultural differences in online expression of social anxiety by analyzing individuals' self-disclosure and support-seeking ...
  78. [78]
    Stress and worry in the 2020 coronavirus pandemic - Journals
    Feb 10, 2021 · The COVIDiSTRESS global survey collects data on early human responses to the 2020 COVID-19 pandemic from 173 429 respondents in 48 countries ...Missing: 2020s | Show results with:2020s
  79. [79]
    Cross-cultural validation of the Worries about COVID-19 and its ...
    Regarding validity, W-COV factors were positively associated with anxiety, depression and stress, and negatively predicted life satisfaction. In ...Missing: 2020s | Show results with:2020s
  80. [80]
    Resolving the neural circuits of anxiety - PMC - PubMed Central - NIH
    Coordinated activity in the amygdala, BNST, vHPC and PFC enables such interpretation of threat in the environment. These structures are highly interconnected, ...
  81. [81]
    The prefrontal cortex, pathological anxiety, and anxiety disorders
    Within the PFC, pathways connecting cortical regions are poised to reduce noise and enhance signals for cognitive operations that regulate anxiety processing ...
  82. [82]
    Anxiety vulnerability is associated with altered anterior cingulate ...
    The anterior cingulate cortex (ACC) is critically involved not only in affective and anxiety processing, but also in error and conflict monitoring.
  83. [83]
    Childhood stressful events, HPA axis and anxiety disorders - PMC
    Early stressful life events and alterations of hypothalamic pituitary adrenal (HPA) axis function seem to have a significant role in the onset of anxiety.
  84. [84]
    Resting state functional connectivity correlates of rumination and ...
    Feb 23, 2021 · Rumination and worry are repetitive negative thinking (RNT) tendencies that contribute to the development and maintenance of internalizing psychopathologies.1 Introduction · 3 Results · 4 DiscussionMissing: hyperactivity | Show results with:hyperactivity<|separator|>
  85. [85]
    Adolescent anxiety disorders and the developing brain
    Aug 4, 2021 · The neural circuit between the mPFC and the amygdala is closely related to cognitive control. The amygdala projects to different areas of the ...
  86. [86]
    COMT genotype and stressful life events predict cortisol increase in ...
    COMT Met allele carriers (worriers) show an allele dosage dependent stronger cortisol stress response. Intriguingly, these differences between genotype groups ...
  87. [87]
    Association of cortisol with neuropsychological assessment in older ...
    Older adults with generalized anxiety disorder (GAD) have elevated diurnal cortisol patterns and show an increased cortisol stress response, which may ...
  88. [88]
    The serotonin-1A receptor in anxiety disorders - PubMed
    Oct 1, 2009 · In healthy subjects, increased anxiety scores might be associated with lower 5-HT1A receptor binding. This overview of preclinical and ...
  89. [89]
    5-HT1A receptor knockout mouse as a genetic model of anxiety
    Low levels of the serotonin(1A) (5-HT(1A)) receptor have been repeatedly found in mood and anxiety disorders. Stress often exacerbates psychiatric disease ...Missing: heightened worry
  90. [90]
    Amygdala-frontal couplings characterizing SSRI and placebo ...
    Mar 26, 2014 · We demonstrate that amygdala-frontal co-activation patterns differentiate effective from ineffective anxiolytic treatments.Missing: worry | Show results with:worry
  91. [91]
    Acute Neurofunctional Effects of Escitalopram in Pediatric Anxiety
    Feb 4, 2021 · Conclusion: In adolescents with GAD, escitalopram increased amygdala-prefrontal connectivity within the first 2 weeks of treatment, and the ...
  92. [92]
    The role of GABA in anxiety disorders - PubMed
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate.Missing: balance deficient
  93. [93]
    Acamprosate calcium as augmentation therapy for anxiety disorders
    This GABA-glutamate imbalance is thought to play a role in the development of anxiety. Acamprosate calcium is thought to restore this chemical imbalance in ...
  94. [94]
    Benzodiazepine interactions with GABA receptors - PubMed
    Benzodiazepines (BZs) produce most, if not all, of their pharmacological actions by specifically enhancing the effects of endogenous and exogenous GABA that ...
  95. [95]
    GABA receptors inhibited by benzodiazepines mediate fast ...
    Benzodiazepines, which are commonly used for the relief of anxiety, are thought to act by enhancing the action of the inhibitory transmitter GABA.
  96. [96]
    Salivary cortisol is associated with diagnosis and severity of late-life ...
    Apr 14, 2008 · We report that late-life GAD is characterized by elevated basal salivary cortisol levels, with higher peak cortisol levels and larger areas under the curve.Missing: elevation | Show results with:elevation
  97. [97]
    Current perspectives of the roles of the central norepinephrine ...
    Central NE activity paradoxically has either anxiogenic or anxiolytic effects, depending on whether the time course of the stress is acute or chronic.
  98. [98]
    Cued for risk: Evidence for an incentive sensitization framework to ...
    We argue that reward uncertainty, as seen in slot machines and games of chance, increases dopaminergic activity in the mesolimbic pathway and enhances the ...
  99. [99]
    Dopamine D4 receptor gene variation is associated with context ...
    ... anxiety). We conducted two studies examining the relationship between the DRD4 variable number tandem repeats polymorphism and attention bias for facial ...
  100. [100]
    Interaction effect of D4 dopamine receptor gene and serotonin ...
    ... anxiety-related behaviors, while a polymorphism in exon III of the D4 dopamine receptor gene (DRD4) has been linked to novelty seeking. The dopaminergic and ...
  101. [101]
    Generalized Anxiety Disorder - StatPearls - NCBI Bookshelf - NIH
    Generalized anxiety disorder is one of the most common mental disorders. Up to 20% of adults are affected by anxiety disorders each year.Introduction · Epidemiology · Evaluation · Treatment / Management
  102. [102]
    Impairment in Pure and Comorbid Generalized Anxiety Disorder and ...
    RESULTS: The prevalences of generalized anxiety disorder at 12 months were 3.1% and 3.3%, respectively, in the National Comorbidity Survey and the Midlife ...
  103. [103]
    Is worry a thought control strategy relevant to obsessive-compulsive ...
    Is worry a thought control strategy relevant to obsessive-compulsive disorder? J Anxiety Disord. 2010 Mar;24(2):269-74. doi: 10.1016/j.janxdis.2009.12.003 ...
  104. [104]
    Attentional interference by threat and post-traumatic stress disorder
    Mar 21, 2013 · ... (worry), which increase PTSD risk. Conversely, attentional ... Attentional interference was related to re-experiencing and avoidance, but not ...
  105. [105]
    Repetitive negative thinking mediates the relationship between self ...
    Aug 29, 2025 · Furthermore, the association between pre-sleep worry and next day's burnout (b = 0.09, 95% CI [0.07, 0.11], p < 0.001) was also moderated by ...
  106. [106]
    Prevalence of sleep disturbances and its associated factors in ...
    Around 60–70 % of patients with GAD reported significant sleep disturbances [8]. Additionally, GAD has the highest comorbidity rate with insomnia [9]. Insomnia ...
  107. [107]
    Mild Worry Symptoms Predict Decline in Learning and Memory in ...
    This research has shown that older adults with clinically elevated anxiety symptoms score lower on global cognitive screening measures,,– as well as on measures ...
  108. [108]
    Risk factors for late-onset generalized anxiety disorder - Nature
    Mar 31, 2015 · Generalized anxiety disorder (GAD) is a chronic and relatively frequent disorder with lifetime prevalence rates of 5–10%. It commonly ...<|control11|><|separator|>
  109. [109]
    Rural–urban disparities in knowledge, behaviors, and mental health ...
    Apr 2, 2021 · The status of anxiety and depression among urban residents was more severe compared to those living in rural areas.
  110. [110]
    Deportation Worry, Cardiovascular Disease Risk Factor Trajectories ...
    Nov 27, 2019 · BackgroundWorry about deportation has been associated with cardiovascular disease risk factors in cross‐sectional research.
  111. [111]
    Anxiety and cardiovascular risk: Review of Epidemiological ... - NIH
    Individuals with high levels of anxiety are at increased risk of coronary heart disease, congestive heart failure, stroke, fatal ventricular arrhythmias, and ...
  112. [112]
    Current Directions in Stress and Human Immune Function - PMC - NIH
    Cortisol is ordinarily anti-inflammatory and contains the immune response, but chronic elevations can lead to the immune system becoming “resistant,” an ...
  113. [113]
    The neurobiology of irritable bowel syndrome | Molecular Psychiatry
    Feb 2, 2023 · Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that affects between 5 and 10% of the general population worldwide.
  114. [114]
    Accelerated telomere shortening in response to life stress - PNAS
    We hypothesized that chronic psychological stress may lead to telomere shortening and lowered telomerase function in peripheral blood mononuclear cells (PBMCs) ...Accelerated Telomere... · Sign Up For Pnas Alerts · ResultsMissing: worry | Show results with:worry
  115. [115]
    Association between anxiety and metabolic syndrome
    Previous studies have demonstrated an association between anxiety and metabolic syndrome (MetS). However, the association is still controversial.
  116. [116]
    Mental health at work - World Health Organization (WHO)
    Sep 2, 2024 · Globally, an estimated 12 billion working days are lost every year to depression and anxiety at a cost of US$ 1 trillion per year in lost ...
  117. [117]
    Climate anxiety in children and young people and their beliefs about ...
    Findings: Respondents across all countries were worried about climate change (59% were very or extremely worried and 84% were at least moderately worried). More ...
  118. [118]
    Helping youth move from climate anxiety to climate action
    Jun 1, 2025 · Similarly, a survey of 10,000 young people ages 16 to 24 in 10 countries found that 59% felt very or extremely concerned about climate change, ...
  119. [119]
    #HealthyAtHome - Mental health
    Adapting to lifestyle changes such as these, and managing the fear of contracting the virus and worry about people close to us who are particularly vulnerable, ...
  120. [120]
    Anxiety and Panic Buying Behaviour during COVID-19 Pandemic ...
    Background: The coronavirus disease 2019 (COVID-19) pandemic had increased population-level anxiety and had elicited panic buying behaviour across the world.
  121. [121]
    Doomscrolling Scale: its Association with Personality Traits ... - NIH
    Oct 19, 2022 · Previous research has revealed a relationship between social media use and increased feelings of depression and anxiety (Vannucci et al., 2017).
  122. [122]
    The Data Behind Your Doom Scroll: How Negative News Takes ...
    Oct 25, 2024 · Analyzing nearly 30 million posts, Stanford scholars reveal how emotional, negative content fuels the viral spread of news on social media.
  123. [123]
    [PDF] Mindfulness-Based Stress Reduction for Generalized Anxiety Disorder
    Dec 12, 2023 · MBSR is an eight-week, group-based treatment that involves mindfulness meditation, body awareness, and yoga (Kabat-Zinn, 1982). MBSR was ...
  124. [124]
    Effects of mindfulness-based stress reduction on anxiety symptoms ...
    The meta-analysis suggested that MBSR significantly reduced anxiety symptoms compared to control conditions at post-treatment.
  125. [125]
    Randomized Controlled Trial of Mindfulness Meditation for ... - NIH
    Feb 1, 2014 · Early research by Kabat-Zinn et al found a decrease in anxiety symptoms after Mindfulness-Based Stress Reduction (MBSR) in patients with GAD, ...
  126. [126]
    Worry Postponement - Psychology Tools
    Worry postponement is a structured cognitive-behavioral technique that helps clients with generalized anxiety disorder (GAD) develop a different relationship ...<|control11|><|separator|>
  127. [127]
    Application of a worry reduction intervention in a medically ...
    Former research has shown that a worry postponement instruction is effective in reducing Subjective Health Complaints (SHC) in non-clinical samples.
  128. [128]
    A meta-analysis of cognitive therapy for worry in generalized anxiety ...
    The results show that CT was effective in reducing pathological worry when compared with non-therapy controls (d = 1.81), and gains were largely maintained at ...
  129. [129]
    Effect of aerobic exercise, slow deep breathing and mindfulness ...
    Jul 12, 2023 · Regarding aerobic exercise, in this study, it decreased the serum cortisol levels by 20.16%. This result is consistent with that of study ...
  130. [130]
    Improving sleep quality leads to better mental health - NIH
    The findings revealed that improving sleep quality had, on average, a medium-sized effect on mental health, including clear evidence that improving sleep ...
  131. [131]
    Omega-3 Supplementation Lowers Inflammation and Anxiety in ...
    In this double blind randomized controlled trial, omega-3 supplementation produced a 14% decrease in stimulated IL-6 production and a 20% reduction in anxiety ...
  132. [132]
    Use and Engagement With Low-Intensity Cognitive Behavioral ...
    Jan 10, 2024 · This study aims to examine engagement with a mobile phone app to support worry management with specific attention directed toward interaction with specific ...
  133. [133]
    Does Using a Mindfulness App Reduce Anxiety and Worry? A ...
    Feb 1, 2023 · Results: four weeks of app access significantly reduced anxiety symptoms, as did 8 weeks, but NHST indicated there were no significant ...<|control11|><|separator|>
  134. [134]
    Approaching Cognitive Behavior Therapy For Generalized Anxiety ...
    Meta-analyses of randomized controlled trials of CBT for GAD (23, 27–29) consistently support its superiority for reducing anxiety and mood symptoms and ...
  135. [135]
    Cognitive‐behavioral therapy (CBT) for generalized anxiety disorder ...
    Cognitive-behavioral therapy (CBT) fundamentally aims to ameliorate generalized anxiety disorder (GAD) symptoms.
  136. [136]
    Understanding Social Anxiety Disorder in Adolescents and ...
    Apr 13, 2018 · Cognitive therapy based on the Clark and Wells (1995) has been compared to a number of other active treatments, and in the six randomized ...
  137. [137]
    Generalized Anxiety Disorder and Panic Disorder in Adults - AAFP
    GAD is defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) as excessive worry that occurs on most days for at least six months ...Abstract · Typical Presentation and... · Diagnosis, Comorbidity, and... · Treatment
  138. [138]
    Escitalopram: A New SSRI for the Treatment of Depression in ...
    In a 12-week trial, treatment with escitalopram (10–20 mg/day) significantly improved symptoms of severe social anxiety disorder relative to placebo in both ...
  139. [139]
    SSRIs and Benzodiazepines for General Anxiety Disorders (GAD)
    May 26, 2020 · Benzodiazepines are not considered safe for continuous use, as this can increase risk for physical dependence (addiction). Furthermore, mixing ...
  140. [140]
    Mindfulness-based cognitive therapy for generalized anxiety disorder
    MBCT may be an acceptable and potentially effective treatment for reducing anxiety and mood symptoms and increasing awareness of everyday experiences in ...
  141. [141]
    A meta-analysis of the efficacy of acceptance and commitment ...
    Conclusions: Our findings indicate that ACT is more effective than treatment as usual or placebo and that ACT may be as effective in treating anxiety disorders, ...
  142. [142]
    Transcranial Magnetic Stimulation (TMS)
    Oct 3, 2025 · Most research has been on rTMS as a treatment for depression, and it has been FDA approved since 2008 for the treatment of medication-resistant ...Missing: 2020s | Show results with:2020s
  143. [143]
    Disorder specific impact of CALM treatment for anxiety disorders in ...
    In terms of principal anxiety disorder outcomes, ITV was statistically superior to UC across 6 months for GAD, PD and SAD, at 12 months for GAD and PD, and at ...
  144. [144]
    Predictors of anxiety recurrence in the Coordinated Anxiety Learning ...
    After anxiety remission, 33% of patients had symptoms recur within a year. Anxiety recurrence was lower in collaborative care (29%) than in usual care (41%).