Fact-checked by Grok 2 weeks ago

Dopaminergic pathways

Dopaminergic pathways are neural circuits in the central nervous system that utilize dopamine as their primary neurotransmitter, originating primarily from clusters of dopaminergic neurons in the midbrain and hypothalamus, and projecting to various target regions to modulate essential functions such as motor control, reward and motivation, cognition, and hormone regulation.^[1] These pathways are critical for maintaining physiological balance, with dysregulation implicated in disorders including Parkinson's disease, schizophrenia, addiction, and endocrine disturbances.^[2] The four major dopaminergic pathways are well-characterized based on their anatomical origins, projections, and functional roles. The nigrostriatal pathway arises from dopaminergic neurons in the substantia nigra pars compacta (A9 cell group) and projects to the dorsal striatum, including the caudate nucleus and putamen, where it facilitates voluntary motor control, habit formation, and procedural learning through interactions with the basal ganglia circuits.^[2] Degeneration of this pathway, particularly loss of dopaminergic neurons in the substantia nigra, is the hallmark of Parkinson's disease, leading to motor symptoms like bradykinesia and rigidity.^[3] In contrast, the mesolimbic pathway originates from the ventral tegmental area (VTA; A10 cell group) and extends to limbic structures such as the nucleus accumbens and olfactory tubercle, playing a pivotal role in reward processing, motivation, and emotional responses by signaling salience and reinforcing behaviors through phasic dopamine release.^[4] Hyperactivity in this pathway is associated with addictive behaviors and the positive symptoms of schizophrenia, such as hallucinations and delusions.^[2] The mesocortical pathway, also stemming from the VTA, projects to the prefrontal cortex and supports higher-order cognitive functions, including working memory, attention, executive control, and decision-making, with dopamine modulating cortical excitability via D1 and D2 receptors.^[3] Hypofunction here contributes to negative symptoms of schizophrenia, cognitive deficits in attention-deficit/hyperactivity disorder (ADHD), and mood dysregulation in depression.^[2] Finally, the tuberoinfundibular pathway (also known as the tuberohypophyseal pathway) originates from dopaminergic neurons in the arcuate nucleus and periventricular nucleus of the hypothalamus (A12 cell group) and projects via the median eminence to the anterior pituitary gland, where it tonically inhibits prolactin secretion through D2 receptor activation, thereby regulating reproductive and lactational processes.^[1] Disruption of this pathway, often due to antipsychotic medications blocking D2 receptors, can lead to hyperprolactinemia and associated endocrine side effects.^[2] Collectively, these pathways form an interconnected dopaminergic system that integrates sensory, motor, and cognitive information, with dopamine acting as a neuromodulator rather than a fast excitatory or inhibitory transmitter, influencing synaptic plasticity and behavioral adaptability across diverse neural circuits.^[4] Advances in neuroimaging and perturbation studies continue to reveal their dynamic interactions, underscoring their therapeutic relevance in neurological and psychiatric conditions.^[3]

Overview

Definition and Composition

Dopaminergic pathways refer to neural circuits originating from clusters of dopaminergic neurons primarily located in the midbrain and hypothalamus, which project to diverse targets in the forebrain, limbic system, striatum, cortex, pituitary gland, and spinal cord, using dopamine as the principal neurotransmitter to modulate neural activity.^[4] These pathways encompass long-range axonal projections that form interconnected networks essential for coordinating brain-wide signaling.^[5] For instance, projections from the ventral tegmental area contribute to circuits like the mesolimbic pathway.^[4] The composition of these pathways includes more than ten distinct dopaminergic cell groups, classified as A8 through A17 in the foundational nomenclature proposed by Dahlström and Fuxe based on histochemical fluorescence mapping of catecholamine neurons.^[5] The major clusters are situated in the substantia nigra pars compacta (SNc; A9 group) and ventral tegmental area (VTA; A10 group) of the midbrain, alongside the arcuate nucleus (A12 group) in the hypothalamus; additional groups such as A8 (retrorubral area), A11 (posterior hypothalamus), and A13–A15 (diencephalic regions) contribute smaller projections.^[6] These neurons, numbering approximately 400,000–600,000 in the human brain, synthesize and release dopamine from axon terminals that often span multiple brain divisions.^[6] These pathways hold fundamental importance in orchestrating integrated physiological processes, including motor control, reward processing, cognitive functions, and endocrine regulation, thereby linking sensory inputs with behavioral outputs.^[4] Their architecture is evolutionarily conserved across vertebrates, from basal chordates like lampreys—where diencephalic dopaminergic neurons project to locomotor regions—to mammals, reflecting ancient origins predating the divergence of major vertebrate lineages and enabling similar modulatory roles in locomotion and motivation.^[5]^[7] Key anatomical features of dopaminergic pathways include extensive, often unmyelinated axonal arborizations that enable diffuse neuromodulation over long distances, with dopamine as the dominant transmitter but not the sole one in all cases.^[5] Subsets of midbrain neurons, particularly in the VTA and SNc, co-release dopamine alongside glutamate via vesicular glutamate transporter 2 (VGLUT2), influencing excitatory signaling in targets like the nucleus accumbens, while others incorporate GABA for inhibitory modulation at striatal synapses.^[8]^[9] Hypothalamic neurons, such as those in the arcuate nucleus, similarly exhibit potential for co-transmission, enhancing their regulatory precision in neuroendocrine contexts.^[8]

Dopamine Synthesis and Metabolism

Dopamine biosynthesis occurs in the cytoplasm of dopaminergic neurons and begins with the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA) by the enzyme tyrosine hydroxylase (TH), which serves as the rate-limiting step in this pathway.^[10] TH requires the cofactor tetrahydrobiopterin (BH4), along with molecular oxygen and iron, to hydroxylate L-tyrosine at the meta position of its phenolic ring.^[10] The subsequent step involves the decarboxylation of L-DOPA to dopamine by aromatic L-amino acid decarboxylase (AADC), also known as DOPA decarboxylase, which does not require additional cofactors beyond pyridoxal phosphate.^[11] Following synthesis, dopamine is rapidly sequestered into synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2), a proton-dependent antiporter that exchanges cytoplasmic dopamine for protons from the vesicle interior, protecting the neurotransmitter from cytosolic degradation.^[12] Upon neuronal depolarization, these vesicles undergo calcium-dependent exocytosis, releasing dopamine into the synaptic cleft in a process triggered by influx of calcium ions through voltage-gated channels.^[13] This release mechanism ensures quantal packaging and controlled expulsion of dopamine, with extracellular concentrations in the synaptic cleft typically ranging from basal levels of 10-100 nM to transient peaks of 1-10 μM during burst firing.^[14] Dopamine's extracellular lifetime is limited by reuptake into presynaptic neurons via the dopamine transporter (DAT), a sodium- and chloride-dependent carrier that facilitates rapid clearance from the synapse.^[15] Metabolically, dopamine is primarily degraded by two enzymes: monoamine oxidase (MAO), located on the outer mitochondrial membrane, oxidatively deaminates dopamine to 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is converted to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase and then to homovanillic acid (HVA) by catechol-O-methyltransferase; alternatively, catechol-O-methyltransferase (COMT), an extracellular enzyme, methylates dopamine to 3-methoxytyramine (3-MT), which is then converted to HVA by MAO and aldehyde dehydrogenase.^[16] These catabolic pathways predominate in different brain regions, with MAO playing a larger role intracellularly and COMT contributing more to extracellular metabolism.^[17] The rate of dopamine synthesis is tightly regulated through end-product feedback inhibition, whereby elevated cytoplasmic dopamine binds to an allosteric site on TH, reducing its activity and preventing overproduction.^[18] This inhibitory mechanism involves both high-affinity and low-affinity dopamine-binding sites on TH, allowing fine-tuned control in response to varying neuronal activity levels.^[18] Such regulation maintains homeostasis in dopamine levels across dopaminergic cell groups, including those in the ventral tegmental area.^[10]

Anatomical Organization

Mesocorticolimbic Pathways

The mesocorticolimbic pathways, comprising the mesolimbic and mesocortical components, originate from dopaminergic neurons clustered in the ventral tegmental area (VTA) of the midbrain, designated as the A10 cell group according to classical histochemical mapping.^[19] These pathways form a unified system that conveys dopaminergic signals to limbic and cortical structures, with the mesolimbic pathway projecting primarily to the nucleus accumbens (particularly its core and shell subregions), olfactory tubercle, and basolateral amygdala, resulting in dense innervation of the ventral striatum.^[20] In contrast, the mesocortical pathway extends from the VTA to the prefrontal cortex (PFC), targeting areas such as the dorsolateral PFC and orbitofrontal cortex, where terminals exhibit sparser and more diffuse arborizations compared to the compact projections in limbic targets.^[21] Shared anatomical features unite these pathways, as both rely on dopamine as the principal neurotransmitter released from VTA neurons, many of which extend collateral branches to both limbic and cortical destinations, enabling coordinated signaling across the system.^[22] Volume transmission, characterized by extrasynaptic dopamine diffusion, predominates in certain terminal fields like the PFC and nucleus accumbens, facilitating broader neuromodulation beyond synaptic clefts.^[23] Anatomical variations arise within VTA subregions, where rostral portions preferentially contribute to mesocortical projections to the PFC, while caudal areas more strongly innervate mesolimbic targets such as the nucleus accumbens and amygdala.^[24] The VTA receives key afferent inputs from the hippocampus and amygdala, which provide glutamatergic and GABAergic modulation to regulate dopaminergic outflow along these pathways.^[20] In vivo visualization of the mesocorticolimbic pathways is achieved through neuroimaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT), employing ligands that bind to the dopamine transporter (DAT) or D2 autoreceptors to map projection density and integrity.^[25] The mesolimbic pathway, in particular, underpins reward-related signaling within this system.^[19]

Nigrostriatal and Tuberoinfundibular Pathways

The nigrostriatal pathway originates from dopaminergic neurons in the substantia nigra pars compacta (SNc), corresponding to the A9 cell group in classical mappings of catecholamine systems.^[26] These neurons project primarily to the dorsal striatum, encompassing the caudate nucleus and putamen, forming a key component of the basal ganglia circuitry.^[26] The pathway exhibits topographic organization, with somatopic mapping that aligns medial-lateral axes in the SNc to corresponding striatal regions, enabling precise spatial segregation of motor-related signals.^[27] This projection contains an exceptionally high density of dopamine, accounting for approximately three-quarters of the brain's total dopamine content due to the fine, extensive axonal arborization.^[28] The nigrostriatal pathway integrates into broader basal ganglia loops, where dopaminergic inputs modulate striatal medium spiny neurons to facilitate coordinated motor output.^[4] Anatomical complexity in this pathway is notably enhanced in primates compared to rodents, featuring more elaborate spiraling projections and greater compartmentalization that support advanced motor refinement.^[29] In contrast, the tuberoinfundibular pathway arises from dopaminergic neurons in the arcuate nucleus of the hypothalamus (A12 cell group) and the periventricular region (A14 group), forming short axons that terminate in the median eminence and influence the anterior pituitary.^[30] These neurons release dopamine directly into the hypophyseal portal vein system, allowing rapid transport to lactotrophs in the pituitary to inhibit prolactin secretion.^[31] Many tuberoinfundibular neurons co-release dopamine with neuropeptides such as neurotensin, enhancing regulatory signaling in neuroendocrine contexts.^[32] This pathway's connectivity is shaped by its proximity to circumventricular organs, including the median eminence itself, which lacks a blood-brain barrier and permits humoral influences on hypothalamic dopamine release.^[33]

Minor and Accessory Pathways

In addition to the major dopaminergic pathways, several minor and accessory projections exist, characterized by smaller populations of neurons and more restricted anatomical distributions. These pathways arise primarily from diencephalic and midbrain dopaminergic cell groups, providing sparse innervation to diverse targets including spinal, hypothalamic, and peripheral structures.^[34]^[35] The hypothalamospinal pathway originates from the A11 and A13 dopaminergic cell groups in the diencephalon, particularly within the posterior hypothalamus and zona incerta, and descends through the lateral funiculus to terminate in the intermediolateral cell column of the spinal cord. This projection modulates autonomic outflow, influencing sympathetic preganglionic neurons that regulate visceral functions such as cardiovascular control.^[36]^[37]^[38] The incertohypothalamic pathway involves local connections from the A13 dopaminergic group in the zona incerta to various hypothalamic nuclei, forming a compact network within the diencephalon. These projections contribute to the integration of sensory and stress-related signals, with terminals identified in regions like the dorsolateral periaqueductal gray that are implicated in defensive responses.^[39]^[35]^[40] Other minor projections include dopaminergic fibers from the ventral tegmental area (VTA) extending to the septal nuclei and hippocampus, providing modest input to limbic structures involved in emotional processing, as well as collaterals from substantia nigra pars compacta (SNc) neurons reaching the subthalamic nucleus, which may fine-tune basal ganglia circuitry. Additionally, sparse dopaminergic elements within the A1 and A2 cell groups of the medulla oblongata contribute to projections influencing peripheral targets such as the kidney and adrenal gland, where dopamine participates in renal sodium handling and adrenomedullary regulation.^[41]^[42]^[43]^[44]^[45] These accessory pathways generally comprise smaller neuron populations compared to major systems, often exhibiting mixed neurotransmitter profiles where dopamine coexists with norepinephrine in select cells. Recent advances in mapping, including optogenetic activation and viral tracing techniques, have confirmed their sparse yet widespread innervation, revealing precise connectivity from diencephalic sources to distant targets like the spinal cord and brainstem.^[34]^[44]^[7]^[35]

Physiological Functions

Reward, Motivation, and Addiction

Dopaminergic signaling plays a central role in reward processing through the mesolimbic pathway, which originates in the ventral tegmental area (VTA) and projects primarily to the nucleus accumbens (NAc).^[46] Dopamine release in this circuit occurs in two main modes: tonic, characterized by steady baseline levels that maintain general arousal and homeostasis, and phasic, involving brief bursts of dopamine neurons in the VTA that signal salient events.^[47] Phasic release, particularly burst firing, encodes reward prediction errors (RPEs), where unexpected rewards elicit strong dopamine surges, while omitted expected rewards cause dips below baseline. This RPE mechanism aligns with the temporal difference (TD) learning model, in which dopamine acts as a teaching signal to update predictions about future rewards by comparing actual outcomes to anticipated ones, facilitating associative learning in downstream structures like the NAc.^[48] Within the NAc, dopamine modulates the balance between D1 and D2 receptor-expressing medium spiny neurons (MSNs) in the shell and core subregions, which differentially influence reward valuation and behavioral output. The NAc shell primarily handles affective aspects of reward, while the core integrates motivational drive with action selection; dopamine binding to D1 receptors on MSNs promotes direct pathway activation for reward seeking, whereas D2 receptor stimulation inhibits the indirect pathway, fine-tuning motivational intensity.^[49] This D1/D2 balance ensures adaptive responses to rewarding stimuli, with disruptions leading to altered hedonic processing. Dopamine also drives motivation by attributing incentive salience to reward-predictive cues, transforming neutral stimuli into motivators that propel approach behaviors. This process, distinct from hedonic "liking," enhances the "wanting" of rewards through mesolimbic dopamine activation, linking the NAc to the orbitofrontal cortex (OFC) for value representation and the ventral pallidum (VP) for motor vigor.^[50] In the VP, dopamine-modulated neurons amplify cue-triggered motivation, sustaining goal-directed actions even without immediate reward consumption.^[51] In addiction, repeated drug exposure sensitizes mesolimbic dopamine circuits, amplifying incentive salience for drug cues while diminishing sensitivity to natural rewards. Psychostimulants like cocaine induce locomotor and motivational sensitization by enhancing dopamine release and altering receptor dynamics, leading to compulsive seeking despite adverse consequences.^[52] A key mechanism involves downregulation of presynaptic D2 autoreceptors on VTA neurons, which normally inhibit dopamine release; this reduction causes tolerance to the drug's euphoric effects by allowing unchecked phasic bursts, perpetuating the addiction cycle.^[53] These processes are studied using behavioral paradigms in rodents, such as conditioned place preference (CPP), where animals associate a chamber with drug rewards, revealing dopamine's role in contextual reward learning via NAc activation. Self-administration models further demonstrate motivational drive, as rats actively press levers for intravenous drug infusions, with dopamine blockade in the NAc reducing intake and highlighting circuit-specific contributions to addiction vulnerability.^[54]

Motor Control and Movement

The nigrostriatal pathway, originating from dopaminergic neurons in the substantia nigra pars compacta and projecting primarily to the dorsal striatum, plays a central role in facilitating voluntary movement through modulation of basal ganglia circuitry.^[55] This pathway enables the selection and execution of motor actions by balancing excitatory and inhibitory signals within striatal medium spiny neurons (MSNs). In the basal ganglia, dopamine from the nigrostriatal pathway differentially influences the direct and indirect pathways to promote or suppress movement. Activation of D1 receptors on MSNs in the direct pathway enhances excitability, leading to inhibition of the internal globus pallidus (GPi) or substantia nigra pars reticulata (SNr), which disinhibits thalamocortical projections and facilitates desired movements.^[55] Conversely, activation of D2 receptors on MSNs in the indirect pathway inhibits these neurons, reducing their output to the external globus pallidus (GPe), which in turn decreases excitation of the subthalamic nucleus (STN), reducing GPi/SNr activity and disinhibiting thalamocortical projections to facilitate the execution of desired movements.^[56] Striatal dopamine thus modulates thalamocortical outputs via these loops involving the globus pallidus and STN, ensuring coordinated motor control. Nigrostriatal dopamine release occurs in distinct firing patterns that support different aspects of motor function. Tonic dopamine, characterized by steady, low-level release from pacemaker firing at approximately 4 Hz, maintains baseline receptor occupancy and sustains posture and ongoing motor stability.^[57] In contrast, phasic bursts, involving transient high-frequency spikes (around 20 Hz), transiently elevate dopamine levels to initiate actions, increasing D1 receptor activation and reducing D2 occupancy to bias toward movement execution.^[58] Dopamine in the dorsolateral striatum (DLS) is particularly involved in motor learning through habit formation, where repeated actions become automated. Enhanced DLS dopamine signaling strengthens synaptic plasticity in MSNs, promoting the shift from goal-directed to habitual behaviors by encoding consistent motor sequences and contextual cues. Electrophysiological studies using single-unit recordings from substantia nigra dopamine neurons reveal their role in action selection. In mice performing motor tasks, approximately 78% of recorded neurons exhibit biphasic firing—increases followed by decreases—correlating with the initiation and switching of actions, predicting behavioral choices with high accuracy (82.7%).^[59] These patterns demonstrate how nigrostriatal dopamine dynamically biases striatal circuits to select appropriate motor programs.^[60]

Cognitive and Executive Processes

Dopaminergic projections from the ventral tegmental area (VTA) to the prefrontal cortex (PFC), particularly targeting layers V and VI, play a pivotal role in modulating cognitive and executive processes such as attention, working memory, and decision-making.^[61] These mesocortical pathways facilitate the integration of sensory information and sustained neural activity necessary for higher-order functions, with dopamine release influencing pyramidal neuron excitability through D1-like receptors.^[62] Interactions between dopaminergic and noradrenergic systems in the PFC further refine these processes, as norepinephrine can enhance dopamine's effects on signal-to-noise ratios in cortical circuits, promoting focused attention.^[63] The relationship between dopamine levels and PFC function follows an inverted-U shaped curve, where optimal concentrations enhance working memory and attention, while deviations impair performance—low levels reduce attentional sustainment, and high levels disrupt focus by overstimulating circuits.^[64] D1 receptors, predominantly expressed on dendritic spines of pyramidal neurons, boost excitability and persistent firing critical for maintaining information in working memory tasks.^[65] In contrast, D4 receptors contribute to gating mechanisms that filter irrelevant stimuli, helping to suppress distractions and maintain cognitive flexibility, particularly in conditions like attention-deficit/hyperactivity disorder where D4 hypofunction exacerbates distractibility.^[66] Executive functions such as set-shifting and impulse control are supported by dopamine's integration in the anterior cingulate cortex (ACC), where it modulates behavioral flexibility and inhibitory control.^[67] For instance, D1 receptor activation in the ACC facilitates effort-based decision-making and response inhibition, preventing impulsive actions.^[68] These roles are evident in paradigms like delay discounting tasks, where PFC dopamine levels correlate with preferences for larger delayed rewards over immediate smaller ones, reflecting enhanced self-control.^[69] Similarly, performance on the Wisconsin Card Sorting Test, which assesses set-shifting and perseveration, shows an inverted-U relationship with prefrontal D1 receptor binding, underscoring dopamine's tuning of cognitive adaptability.^[70]

Endocrine and Homeostatic Regulation

Dopamine plays a pivotal role in endocrine regulation, particularly through the tuberoinfundibular pathway, where it acts as the primary prolactin-inhibiting factor (PIF) by binding to D2 receptors on anterior pituitary lactotroph cells, thereby suppressing prolactin synthesis and secretion.^[71] This tonic inhibition is essential for maintaining basal prolactin levels, with dopamine concentrations in the hypophyseal portal blood directly modulating lactotroph activity via G-protein-coupled D2 receptor signaling that inhibits adenylyl cyclase and reduces intracellular cAMP.^[72] Disruption of this pathway, such as in hyperprolactinemia, underscores dopamine's dominance as the key regulator of prolactin homeostasis.^[73] In homeostatic regulation, dopamine contributes to autonomic balance via the hypothalamospinal pathway, where dopaminergic projections from the A11 nucleus in the posterior hypothalamus provide tonic inhibition to preganglionic sympathetic neurons in the spinal cord, thereby modulating sympathetic outflow and cardiovascular tone.^[74] This descending dopaminergic control helps maintain baseline sympathetic activity, preventing excessive sympathoadrenal responses under normal conditions.^[38] Additionally, peripherally synthesized dopamine in the kidney acts as a natriuretic hormone, promoting sodium excretion through activation of D1-like receptors on renal tubular epithelium, which inhibits sodium-potassium ATPase and enhances natriuresis in response to high sodium intake.^[75] This local renal dopamine system operates independently of central innervation, with synthesis from circulating L-DOPA regulated by dietary sodium to fine-tune fluid and electrolyte balance.^[76] Dopamine also influences circadian rhythms by modulating hypothalamic oscillators, particularly in the suprachiasmatic nucleus (SCN) and arcuate nucleus, where it synchronizes daily oscillations in hormone release and metabolic processes through D2 receptor-mediated interactions with clock genes like Per1 and Per2.^[77] This modulation ensures phased alignment of endocrine outputs, such as cortisol and melatonin, with environmental light-dark cycles, with dopamine release peaking during active phases to reinforce rhythmicity.^[78] Feedback loops involving gonadal steroids further regulate dopaminergic activity in the arcuate nucleus, where estrogen and testosterone modulate the activity and tyrosine hydroxylase expression in tuberoinfundibular dopamine (TIDA) neurons, creating a reciprocal interaction that influences reproductive hormone secretion.^[79] For instance, estrogen enhances dopamine turnover in these neurons during the estrous cycle, providing negative feedback to gonadotropin-releasing hormone (GnRH) pulsatility.^[80] Peripheral dopamine synthesis extends to non-neuronal tissues, with the kidney producing dopamine locally via aromatic L-amino acid decarboxylase (AADC) in proximal tubules to regulate sodium handling and blood pressure, independent of neural input.^[81] Similarly, in the gut, enteric neurons and epithelial cells synthesize dopamine, accounting for approximately 50% of total body dopamine, which locally modulates gastrointestinal motility, mucosal blood flow, and mucosal integrity through D2-like receptors, contributing to digestive homeostasis.^[82] This peripheral production supports autocrine and paracrine functions without significant contribution to central pools.^[83]

Regulatory Mechanisms

Intrinsic Autoregulation

Intrinsic autoregulation in dopaminergic pathways refers to the intrinsic mechanisms that dopaminergic neurons employ to self-regulate dopamine signaling and maintain homeostasis. These processes primarily occur at the presynaptic level and involve feedback loops that adjust dopamine synthesis, release, and reuptake in response to local dopamine concentrations. Key components include autoreceptors, transporters, and vesicular machinery that fine-tune neuronal activity without reliance on external inputs. Presynaptic D2 autoreceptors, located on the somatodendritic regions and terminals of dopaminergic neurons in the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA), play a central role in this regulation by inhibiting dopamine synthesis and release through Gi/o protein-coupled signaling pathways. Activation of these autoreceptors hyperpolarizes the neuron via G-protein inwardly rectifying potassium (GIRK) channels and reduces voltage-gated calcium influx, thereby suppressing action potential-dependent dopamine release. With chronic dopaminergic activity, such as during prolonged stimulation or drug exposure, D2 autoreceptors undergo desensitization, which diminishes their inhibitory feedback and can lead to enhanced dopamine transmission over time. This desensitization involves changes in receptor phosphorylation and internalization, allowing for adaptive responses to sustained endogenous dopamine levels. Dopaminergic neurons in the SNc and VTA exhibit intrinsic pacemaker activity, characterized by spontaneous, regular firing at frequencies of 2-5 Hz, which sustains basal dopamine tone. D2 autoreceptors mediate pauses in this firing pattern by inducing hyperpolarization in response to somatodendritically released dopamine, thereby providing a self-limiting mechanism to prevent excessive excitation. Endogenous dopamine also exerts feedback inhibition on tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, primarily through D2 autoreceptor activation that reduces TH phosphorylation and activity, thereby tuning synthesis to match release demands; this process is detailed further in discussions of dopamine synthesis and metabolism. The dopamine transporter (DAT), expressed on presynaptic terminals, regulates extracellular dopamine levels by facilitating reuptake into the neuron, with its activity modulated by phosphorylation events that alter transport kinetics and membrane trafficking. Phosphorylation by kinases such as protein kinase C (PKC) or mitogen-activated protein kinase (MAPK) can decrease DAT surface expression and reuptake efficiency, providing an additional layer of intrinsic control to prevent dopamine accumulation. Vesicular monoamine transporter 2 (VMAT2) governs the packaging of dopamine into synaptic vesicles, operating as a proton-dependent antiporter that exchanges cytosolic dopamine for protons, with release probability influenced by vesicular pH gradients maintained by the vacuolar H+-ATPase. This pH-dependent mechanism ensures efficient loading and quantal release, contributing to the homeostasis of dopamine storage and exocytosis.

Extrinsic Modulation

Dopaminergic pathways are subject to extrinsic modulation by various neural and hormonal systems, which exert influence through synaptic inputs and circulating factors to fine-tune dopamine neuron activity in regions such as the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). These modulatory inputs integrate signals from distant brain areas and peripheral sources, enabling adaptive responses to environmental cues, stress, and physiological states. Glutamatergic, GABAergic, serotonergic, cholinergic, orexinergic, and hormonal mechanisms collectively shape the excitability, firing patterns, and neurotransmitter release of dopamine neurons, often in a pathway-specific manner. Glutamatergic inputs provide excitatory drive to dopamine neurons primarily via ionotropic NMDA and AMPA receptors expressed on VTA and SNc somata and dendrites. These receptors facilitate depolarization and burst firing, enhancing dopamine release in target areas. Major sources include projections from the prefrontal cortex (PFC), which convey cognitive and executive signals to the VTA, and the pedunculopontine nucleus (PPN), which delivers locomotor-related excitation to both VTA and SNc dopamine neurons. Activation of these glutamatergic afferents is critical for phasic signaling in reward and motor contexts, as PPN glutamatergic neurons specifically control spike patterning in SNc dopamine cells.^[84]^[85] In contrast, GABAergic inputs impose inhibitory control, often through tonic suppression that limits excessive dopamine release. Local GABAergic interneurons within the VTA and SNc provide direct perisomatic inhibition via GABA_A and GABA_B receptors, dampening dopamine neuron excitability. Additionally, striatal feedback loops, involving GABAergic medium spiny neurons projecting back to the SNc, reinforce this suppression, particularly during ongoing motor activity. These mechanisms maintain balanced dopamine tone in the striatum, preventing overflow that could disrupt motor control. Tonic GABAergic activity is further supported by uptake transporters that sustain extracellular GABA levels, thereby inhibiting dopamine release under baseline conditions.^[86]^[87] Serotonergic modulation occurs via 5-HT2A and 5-HT2C receptors, which exert opposing effects on dopamine release, particularly in mesolimbic reward pathways. The 5-HT2A subtype generally facilitates dopamine neuron activity and release in the nucleus accumbens, promoting reward-seeking behaviors, while 5-HT2C activation inhibits these processes, acting as a brake on impulsivity. These receptors are expressed on dopamine neuron terminals and modulate presynaptic dopamine efflux in response to raphe nucleus projections. Such bidirectional control allows serotonin to balance motivational drive, with 5-HT2C antagonism enhancing dopamine-mediated locomotion in preclinical models.^[88]^[89] Orexinergic modulation, mediated by orexin (hypocretin) neurons in the lateral hypothalamus, influences dopaminergic activity primarily through OX1 and OX2 receptors on VTA dopamine neurons. Orexin excites these neurons, promoting burst firing and enhancing dopamine release in the nucleus accumbens, which supports arousal, motivation, and reward processing. This modulation integrates with reward circuits and is implicated in addiction and sleep-wake regulation, with recent studies (as of 2025) showing context-dependent effects on anxiety-like behaviors in orexin receptor-deficient models.^[90]^[91] Hormonal influences further regulate dopaminergic signaling, with estrogen and stress-related factors like cortisol acting through corticotropin-releasing hormone (CRH). Estrogen enhances D2 receptor sensitivity and signaling in striatal and mesolimbic regions, increasing dopamine responsiveness and supporting sex-specific behaviors such as motivation. This effect involves rapid non-genomic actions that upregulate D2 receptor function, particularly in females during reproductive cycles. Under stress, CRH released from the hypothalamus activates CRH receptors on VTA dopamine neurons, elevating firing rates and dopamine release to promote adaptive arousal. Cortisol, downstream of CRH, amplifies this by sensitizing dopamine systems in the ventral striatum, though chronic elevation can lead to dysregulation.^[92]^[93]^[94] Cholinergic inputs, primarily from the PPN and laterodorsal tegmental nucleus, facilitate burst firing of dopamine neurons through nicotinic acetylcholine receptors (nAChRs) on VTA and SNc cells. These α4β2 and α7 nAChRs depolarize dopamine neurons, promoting phasic bursts that signal salience and reward. Nicotinic activation enhances dopamine release in the nucleus accumbens, underpinning the reinforcing effects of acetylcholine in motivational circuits. This modulation integrates with glutamatergic drive to gate adaptive behaviors.^[95]^[96]

Development and Plasticity

Embryonic and Postnatal Development

The development of dopaminergic pathways begins in the embryonic stage with the specification of midbrain dopamine (mDA) neurons in the ventral midbrain floor plate, driven by Sonic hedgehog (Shh) signaling and the transcription factor Foxa2, which together induce the expression of key determinants like Lmx1a and Nurr1 for dopaminergic fate.^[97] These progenitors arise around embryonic day 8.5 (E8.5) in mice, with initial neurogenesis peaking between E10.5 and E11.5, establishing the foundational populations destined for the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA).^[98] Genetic factors such as the transcription factors PITX3 and Nurr1 are essential for the survival and differentiation of SNc dopaminergic neurons; Nurr1 (also known as NR4A2) regulates early specification and maintenance, while PITX3 promotes terminal differentiation and protects against apoptosis in a subset of these neurons postnatally.^[99]^[100] Mutations or deficiencies in these factors lead to selective loss of SNc neurons, highlighting their role in pathway robustness.^[101] Following specification, mDA neurons undergo tangential migration from the ventricular zone to their final positions in the VTA and SNc, completing this process by approximately E13 in rodents, guided by cues like reelin and chemokine signaling to form the nascent mesostriatal and mesolimbic projections.^[102] This migration establishes the basic anatomical framework, with axons beginning to extend toward target regions like the striatum by late embryogenesis. In humans, mDA neuron generation occurs earlier, between 5 and 9 weeks post-conception, with initial functional connectivity emerging by the third trimester as dopaminergic fibers innervate basal ganglia and limbic structures, supporting basic motor and reward-related responses in utero.^[103]^[104] Postnatally, dopaminergic pathways undergo extensive refinement, with axonal arborization expanding rapidly in rodents during the first few weeks and peaking in density during adolescence (around postnatal day 30-60 in rats), particularly in mesocortical projections to the prefrontal cortex.^[105] This maturation coincides with upregulated expression of dopamine transporters (DAT) and vesicular monoamine transporter 2 (VMAT2), which increase progressively from early postnatal stages to adolescence, enhancing dopamine reuptake and vesicular packaging to support heightened signaling demands.^[106] In humans, prefrontal dopaminergic projections continue to mature into early adulthood (late teens to mid-20s), with synaptic pruning and myelination refining connectivity for executive functions.^[107] These changes render the system vulnerable during critical periods; for instance, prenatal alcohol exposure disrupts VTA dopaminergic neuron activity and survival, leading to persistent hypofunction in reward pathways.^[108] Sex differences emerge during development, with males showing earlier and more pronounced increases in striatal dopamine receptor density and faster maturation of mesolimbic projections compared to females, influenced by gonadal hormones and potentially contributing to divergent vulnerability profiles.^[109] Overall, these embryonic and postnatal processes ensure the progressive assembly of dopaminergic circuits, transitioning from basic functionality in gestation to sophisticated integration in adulthood.

Synaptic Plasticity and Adaptations

Synaptic plasticity in dopaminergic pathways encompasses activity-dependent modifications that strengthen or weaken connections, enabling adaptation to environmental and experiential demands. Long-term potentiation (LTP) and long-term depression (LTD) at dopaminergic synapses, particularly in the nucleus accumbens, involve bidirectional trafficking of AMPA receptors to postsynaptic sites, which alters synaptic efficacy in response to dopamine signaling.^[110] This process is modulated by dopamine D1 and D2 receptors, where activation promotes insertion or removal of AMPARs, respectively, supporting reward-related learning.^[111] Endocannabinoid signaling further refines these changes by retrogradely inhibiting presynaptic release, thereby gating LTP induction through CB1 receptor activation on dopaminergic terminals.^[112] Adaptations in volume transmission, a non-synaptic mode of dopamine diffusion, allow for broader signaling ranges that adjust based on extracellular dynamics. Astrocytes play a key role via gliotransmission, releasing modulators like adenosine that interact with dopamine receptors to fine-tune diffusion distances and prevent spillover into adjacent circuits.^[113] This glial modulation can extend or restrict dopamine's effective range, adapting to network activity levels and maintaining balanced neuromodulation in regions like the striatum.^[114] Experience-dependent plasticity shapes dopaminergic circuits through structural remodeling influenced by environmental factors. Environmental enrichment enhances dendritic branching in ventral tegmental area (VTA) dopamine neurons, increasing connectivity and responsiveness to novel stimuli.^[115] Conversely, chronic stress triggers dendritic remodeling, such as spine retraction in prefrontal-projecting dopamine neurons, which alters motivational drive but can be reversible with stress cessation.^[116] At the molecular level, brain-derived neurotrophic factor (BDNF) signaling via TrkB receptors promotes dopamine neuron survival and synaptic strengthening by activating downstream pathways like PI3K/Akt, which support dendritic growth and resistance to atrophy.^[117] Recent studies have revealed a structural continuum in dopaminergic synaptic vesicles, enabling hybrid release modes that blend classical full fusion with partial (kiss-and-run) exocytosis, allowing flexible neurotransmitter output tuned to activity demands.^[118] This versatility supports adaptive plasticity without discrete switching between modes.

Pathophysiological Implications

Neurological Disorders

Dopaminergic dysfunction in the nigrostriatal pathway is a hallmark of Parkinson's disease (PD), characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to dopamine depletion in the striatum.^[119] This degeneration is primarily driven by the accumulation of alpha-synuclein protein in Lewy bodies, which disrupts neuronal function and promotes cell death.^[120] The resulting loss of dopaminergic input imbalances the direct and indirect striatal pathways, with particular impairment in D2 receptor-mediated inhibition of the indirect pathway, contributing to bradykinesia—a core motor symptom marked by slowed movement initiation and execution.30127-1) As detailed in the anatomical organization section, this pathway's vulnerability underscores PD's motor deficits, with neuronal loss exceeding 50% before symptoms manifest.^[119] In Huntington's disease (HD), dopaminergic alterations in the striatal pathway exhibit a biphasic pattern, beginning with early hypersensitivity and hyperdopaminergia that exacerbates choreiform movements, followed by progressive dopamine depletion as medium spiny neurons degenerate.^[121] This initial hypersensitivity arises from reduced dopamine reuptake and enhanced release in the striatum, leading to overstimulation of postsynaptic receptors before the loss of striatal targets diminishes dopaminergic signaling.^[122] The transition to depletion correlates with advanced neuronal loss, contributing to the shift from hyperkinetic to hypokinetic symptoms in later stages.^[121] Restless legs syndrome (RLS) involves deficiency in the hypothalamic A11 diencephalospinal dopaminergic pathway, which provides inhibitory modulation to spinal sensory and motor circuits.^[123] Reduced dopamine release from A11 neurons disrupts this descending control, resulting in sensory disturbances and involuntary movements, particularly during rest.^[124] Iron dysregulation further impairs dopamine synthesis in this region, amplifying the deficiency.^[123] Dystonia features an imbalance in the nigrostriatal pathway's direct and indirect circuits, often with hyperfunction of the direct pathway due to altered dopaminergic modulation in the striatum.^[125] This leads to excessive facilitation of thalamic output and reduced inhibition via the indirect pathway, promoting sustained muscle contractions and abnormal postures.^[126] Dopaminergic hypersensitivity or irregular release in the basal ganglia exacerbates the circuit dysfunction, distinguishing primary dystonias from other movement disorders.^[125] Therapeutic strategies target these dopaminergic deficits, with L-DOPA serving as the cornerstone for PD by replenishing striatal dopamine levels and alleviating bradykinesia and rigidity.^[127] For advanced cases, deep brain stimulation (DBS) of the subthalamic nucleus normalizes basal ganglia hyperactivity, improving motor function with sustained benefits observed up to five years post-implantation.^[128] Recent 2025 advancements incorporate nanotechnology, such as nanoparticle-based wireless DBS systems that enable targeted photothermal modulation of alpha-synuclein aggregates and dopamine neuron restoration, enhancing precision and reducing invasiveness.^[129]

Psychiatric and Metabolic Disorders

Dopaminergic pathways are implicated in various psychiatric disorders through imbalances in mesolimbic and mesocortical signaling. In schizophrenia, hyperdopaminergia in the mesolimbic pathway contributes to positive symptoms such as hallucinations and delusions, while hypodopaminergia in the mesocortical pathway underlies negative symptoms and cognitive deficits.^[130] Recent updates to the dopamine hypothesis, as of 2025, emphasize the interplay between dopaminergic dysregulation and glutamatergic signaling, where disruptions in NMDA receptor function lead to aberrant dopamine release in subcortical regions, exacerbating psychosis.^[131] Preclinical models further support this, showing that GABAergic and glutamatergic network disturbances interact with dopaminergic hyperactivity to drive symptom severity.^[130] Attention-deficit/hyperactivity disorder (ADHD) involves mesocortical dopaminergic deficits that impair attention and executive function, with reduced dopamine availability in prefrontal circuits leading to inattention and impulsivity.^[132] Genetic polymorphisms in the dopamine transporter (DAT1) gene are associated with ADHD susceptibility, altering dopamine reuptake and contributing to lower synaptic dopamine levels in attention-related pathways.^[133] These variants, particularly the 10-repeat allele, have been linked to altered left-sided inattention in affected individuals.^[134] In addiction, repeated exposure to substances sensitizes the mesolimbic pathway, enhancing dopamine release in the nucleus accumbens and promoting compulsive drug-seeking behavior through incentive sensitization mechanisms.^[135] This dysregulation amplifies "wanting" cues associated with rewards, as detailed in reward and motivation functions, while detailed synaptic adaptations are covered elsewhere.^[136] Major depressive disorder features ventral tegmental area (VTA) dopaminergic hypofunction contributing to anhedonia, the diminished ability to experience pleasure from rewarding stimuli.^[137] Reduced D1 receptor expression in the prefrontal cortex further exacerbates motivational deficits, impairing reward processing and decision-making.^[138] Optogenetic studies confirm that stimulating VTA dopaminergic neurons can alleviate anhedonia-like behaviors in depressive models.^[139] Emerging metabolic roles of dopaminergic signaling extend beyond neuronal functions, particularly in 2025 research highlighting peripheral and glial contributions. In pancreatic beta-cells, dopamine acts via autocrine signaling through D2-like receptors to inhibit insulin secretion, modulating glucose homeostasis and potentially linking dopaminergic dysregulation to diabetes risk.^[140] Astrocytic dopamine signaling in the striatum influences obesity by modulating behavioral flexibility and whole-body metabolism, where high-fat diets alter astrocyte structure and dopamine-dependent reward processing, promoting overeating.^[141] Dopaminergic decline in Alzheimer's disease, observed in midbrain pathways, contributes to cognitive and motivational impairments, with degeneration of VTA neurons exacerbating amyloid-beta pathology and synaptic loss.^[142] Non-neuronal dopaminergic effects include immune modulation via D5 receptors on T-cells, where dopamine binding enhances T-cell activation and cytokine production, such as IL-10 and TNFα, influencing adaptive immunity.^[143] D5 signaling plays a dual role in autoimmunity, potentiating Th17 responses while favoring regulatory T-cell suppression in experimental models.^[144]

References

[1]
Current Review of the Function and Regulation of ... - PubMed Central
Dec 21, 2023 · The tuberoinfundibular pathway initiates its course in the arcuate nucleus of the hypothalamus at the brain's base. The neurons have a ...
[2]
The interplay of dopamine metabolism abnormalities and ... - Nature
Nov 7, 2022 · The fourth pathway is the so-called tuberoinfundibular dopaminergic pathway consisting of the projections from the arcuate nucleus and the ...
[3]
Dopaminergic Neurotransmission in the Human Brain: New Lessons ...
Animal studies have revealed that there are three major dopaminergic pathways: nigrostriatal, mesolimbic, and mesocortical. Nigrostriatal DA plays a crucial ...
[4]
Dopaminergic Neurons and Brain Reward Pathways
This review provides a comprehensive discussion on how Wnt/β-catenin and sonic hedgehog–Smoothened signaling mechanisms control the specification and expansion ...
[5]
The Evolution of Dopamine Systems in Chordates - Frontiers
Mar 28, 2011 · Dopamine (DA) neurotransmission in the central nervous system (CNS) is found throughout chordates, and its emergence predates the divergence of chordates.Comparative Anatomy of... · Determination and... · Hypothesis on the Evolution of...
[6]
Diversity matters – heterogeneity of dopaminergic neurons in the ...
It must be emphasized that the A8–A10 nomenclature relates exclusively to dopaminergic neurons in the ventral mesencephalon, whereas the anatomical nomenclature ...
[7]
A descending dopamine pathway conserved from basal vertebrates ...
Apr 11, 2016 · Here, we show that this descending dopaminergic pathway is conserved in higher vertebrates. We found that dopamine is released in salamander ...
[8]
Co-transmission of dopamine and glutamate - PMC - PubMed Central
Glutamate co-release from mesolimbic dopamine neurons may also influence these same neurons through presynaptic AMPA and NMDA receptors. Glutamate released may ...
[9]
GABA co-released from striatal dopamine axons dampens phasic ...
Because GABA synthesis does not occur in DA neurons, GABA used for co-release is instead taken up by DA axons via plasma membrane GATs. Initial evidence for ...
[10]
Tyrosine Hydroxylase and Regulation of Dopamine Synthesis - PMC
Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA.
[11]
The catecholamine system in health and disease - PubMed Central
L-3,4-Dihydroxyphenylalanine (DOPA) decarboxylase (DDC), which catalyzes the second step of CA-biosynthesis from tyrosine, decarboxylating L-DOPA to dopamine, ...3.1. Tyrosine... · 4.1. Human Tyrosine... · 5.1. 3. Tyrosine...
[12]
The vesicular monoamine transporter 2 - PubMed Central - NIH
Active transport of neurotransmitters into synaptic vesicles is required for their subsequent exocytotic release. In the monoamine system, this process is ...
[13]
Mechanisms and regulation of dopamine release - PMC
Dopamine release is triggered by Ca2+ and is steeply dependent on extracellular Ca2+, with potential differences between axonal release and somatodendritic ...
[14]
Where is Dopamine and How Do Immune Cells See It?
The distances in the striatum are suggested to be 2 – 7 μm for 1 uM dopamine, and 7 – 20 μm for 10 nM dopamine (Beyene et al. 2017; Cragg and Rice 2004; Staal ...
[15]
Regulation of Tyrosine Hydroxylase Expression and ... - NIH
Tyrosine hydroxylase (TH) and dopamine transporters (DATs) regulate dopamine (DA) neurotransmission at the biosynthesis and reuptake steps, respectively.
[16]
Dopamine - StatPearls - NCBI Bookshelf - NIH
... 3-methoxytyramine (3-MT), while monoamine oxidase-B (MAO-B) will rapidly metabolize 3-MT to homovanillic acid (HVA).[16][17] Alternatively, it may undergo ...
[17]
Monoamine oxidase inactivation: from pathophysiology to therapeutics
(2) In the second pathway, COMT metabolizes DA into 3-methoxytyramine (3-MT), which is then converted into HVA by MAO and ALDH. The chemical reaction catalyzed ...
[18]
Tyrosine hydroxylase activity is regulated by two distinct dopamine ...
The low-affinity dopamine-binding site has the potential to be the primary mechanism responsible for the regulation of catecholamine synthesis under most ...
[19]
The Formation and Function of the VTA Dopamine System - PMC
Mar 30, 2024 · 3.1. The VTA to the NAc dopaminergic projection constitutes the mesolimbic dopamine system, which is important for motivated behaviors, ...
[20]
Mesolimbic Pathway - an overview | ScienceDirect Topics
Mesolimbic pathway In this pathway, dopaminergic projections start from the VTA and end toward the VTA, amygdala, nucleus accumbens, and pyriform cortex.Introduction · Neuroanatomy and... · Mesolimbic Pathway...
[21]
Mesocortical Pathway - an overview | ScienceDirect Topics
The mesocortical pathway is defined as a neural pathway that projects from the ventral tegmental area (VTA) of the midbrain to the prefrontal cortex, ...
[22]
Long-range projection neurons of the mouse ventral tegmental area
May 19, 2015 · Pathways arising from the ventral tegmental area (VTA) release dopamine and other neurotransmitters during the expectation and achievement ...
[23]
Relative Contributions and Mapping of Ventral Tegmental Area ...
The ventral tegmental area (VTA) is a heterogeneous midbrain structure that contains dopamine (DA), GABA and glutamate neurons that project to many different ...
[24]
Rostral-caudal differences in the effects of intra-VTA muscimol on ...
The rostral VTA has fewer DA neurons and a greater proportion of GABA neurons than the caudal VTA (19;27).
[25]
Imaging of Dopamine in PD and Implications for Motor and ... - NIH
Dopamine neurons of the mesocortical pathway have unconventional characteristics, including lack of DAT and D2 autoreceptors (16), which may limit their ...
[26]
Functional Neuroanatomy of the Basal Ganglia - PMC
The striatum is by far the largest subcortical brain structure in the mammalian brain ... The nigrostriatal system originates from the SNc (A9 group from ...
[27]
Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit ...
Dec 27, 2010 · We found that the nigrostriatal projection is topographically organized along a medial–lateral axis and includes projections from throughout the ...
[28]
Nigrostriatal Pathway - an overview | ScienceDirect Topics
The nigrostriatal pathway is a major dopaminergic circuit that orchestrates motor, limbic, and cognitive functions, with dopamine serving as a key ...
[29]
Striatonigrostriatal Pathways in Primates Form an Ascending Spiral ...
Taken together, there was a general inverse dorsal–ventral topography in both the striatonigral projections and nigrostriatal projections.
[30]
Hypophysis Hormone - an overview | ScienceDirect Topics
... A12 group within the arcuate nucleus and the A14 group in the anterior PVH. The caudal A12 dopamine neurons are further described as tuberoinfundibular ...
[31]
Prolactin and antipsychotic medications: mechanism of action
The tubero-infundibular tract, which is a system of short axons running along the base of the hypothalamus, releases dopamine into the portal veins of the ...<|control11|><|separator|>
[32]
Coexistence of dopamine and neurotensin in hypothalamic arcuate ...
The coexistence of dopamine and neurotensin in the same neuronal perikarya in the arcuate nucleus of the rat hypothalamus was examined by combined ...
[33]
Functional Anatomy of the Hypothalamus and Pituitary - NCBI - NIH
Nov 28, 2016 · The hypothalamic tuberoinfundibular system comprises all neurons in the brain that send axonal projections to the external zone of the median ...
[34]
Dopaminergic Cell Groups - an overview | ScienceDirect Topics
The diencephalic dopaminegic neurons are divided into four groups named A11, A12, A13, and A14 in rodents (Albanese et al., 1986). Only the A11 dopaminergic ...
[35]
A discrete dopaminergic projection from the incertohypothalamic ...
Dec 5, 2013 · The A11 dopaminergic cell group appears at Bregma level −3 mm where it intermingles with the caudal A13 group. However, dopaminergic cells ...
[36]
Neuroanatomical Study of the A11 Diencephalospinal Pathway in ...
The A11 group is the unique TH-IR cell group projecting to the spinal cord with some fundamental differences compared to other dopaminergic systems, notably ...
[37]
Parallel descending dopaminergic connectivity of A13 cells to the ...
May 22, 2018 · The A13 cell group projects to the central nucleus of the amygdala, involved in the expression of fear and other emotional behaviors. The ...
[38]
The hypothalamic-spinal dopaminergic system: a target for pain ...
Descending pathways projecting to the spinal cord include, among others, noradrenergic, serotonergic, γ-aminobutyric acid (GABA)ergic, and dopaminergic fibers.
[39]
Evidence of an incerto-hypothalamic dopamine neurone system in ...
A previously unknown catecholamine-containing fibre system has been revealed in the zona incerta, hypothalamus and the caudal septum.
[40]
Evidence that the dopaminergic incerto-hypothalamic tract has a ...
These findings indicate that the dopaminergic incerto-hypothalamic tract which has nerve terminals in the ZI and AH has a stimulatory role in the control of ...
[41]
Tactile stimulation activates dopamine release in the lateral septum
The lateral septal nucleus receives dopaminergic projections primarily from the VTA. These afferents make direct synaptic contacts with perikarya and dendrites ...
[42]
Circuit Architecture of VTA Dopamine Neurons Revealed by ...
Dopamine (DA) neurons in the midbrain ventral tegmental area (VTA) integrate complex inputs to encode multiple signals that influence motivated behaviors.Missing: hippocampus | Show results with:hippocampus
[43]
Anatomy and Connectivity of the Subthalamic Nucleus in Humans ...
Apr 21, 2020 · Dopaminergic nigrostriatal fibers pass dorsomedially to the STh through the medial forebrain bundle, where they enter the Fields of Forel and ...Anatomy of the Subthalamic... · Subthalamic Nucleus... · STh Connections in Non...
[44]
Rat medulla oblongata. II. Dopaminergic, noradrenergic (A1 and A2 ...
Mar 15, 1985 · The A1 cell group in the ventrolateral medulla consisted almost exclusively of noradrenergic neurons (TH- and DBH-positive and PNMT-negative).
[45]
Reward-based hypertension control by a synthetic brain–dopamine ...
Oct 14, 2013 · In addition to the brain, dopamine receptors are also expressed in peripheral tissues such as kidney, adrenal glands, or blood vessels, and ...
[46]
The Brain's Reward System in Health and Disease - PMC
MSNs outputs generate two pathways: the direct pathway formed by dopamine D1 receptor (D1R) expressing medium spiny neurons (dMSNs) and the indirect pathway by ...
[47]
Dopamine reward prediction-error signalling: a two-component ...
These responses code a temporal reward prediction error, which reflects the difference in value between a received reward and a predicted reward at each moment ...
[48]
A framework for mesencephalic dopamine systems based on ...
Mar 1, 1996 · A framework for mesencephalic dopamine systems based on predictive Hebbian learning. PR Montague ... 1996, 16 (5) 1936-1947; https://doi.org ...
[49]
Nucleus accumbens medium spiny neurons subtypes signal both ...
Aug 28, 2019 · Our findings demonstrate that D1- and D2-MSNs can bidirectionally control reward and aversion, explaining the existence of controversial studies in the field.
[50]
The debate over dopamine's role in reward: the case for incentive ...
Oct 27, 2006 · Dopamine appears necessary for normal 'wanting', and dopamine activation can be sufficient to enhance cue-triggered incentive salience.
[51]
Ventral Pallidum Roles in Reward and Motivation - PMC
In recent years the ventral pallidum has become a focus of great research interest as a mechanism of reward and incentive motivation.
[52]
Addiction, Dopamine, and the Molecular Mechanisms of Memory
If cocaine or amphetamine is used repeatedly, some acute drug effects may diminish (“tolerance”), while others are enhanced (“sensitization”). Whether tolerance ...
[53]
Amphetamine Self-Administration Attenuates Dopamine D2 ... - Nature
Feb 11, 2014 · Reduced D2 autoreceptor function could lead to enhanced DA signaling and ultimately addiction-related behavior. RGS2 may be a potential non- ...
[54]
Conditioned Place Preference - Methods of Behavior ... - NCBI - NIH
The conditioned place preference paradigm is a standard preclinical behavioral model used to study the rewarding and aversive effects of drugs.
[55]
https://doi.org/10.1016/j.neuron.2012.09.023
[56]
https://doi.org/10.1523/JNEUROSCI.20-24-08987.2000
[57]
https://doi.org/10.1523/JNEUROSCI.04-11-02866.1984
[58]
https://doi.org/10.1523/JNEUROSCI.04-11-02877.1984
[59]
https://doi.org/10.1016/j.neuron.2017.02.029
[60]
https://doi.org/10.1038/nature11846
[61]
Dopamine Dl Receptor Actions in Layers V-VI Rat Prefrontal Cortex ...
The ionic mechanisms by which dopamine (DA) regulates the excitability of layers V-VI prefrontal cortex (PFC) output neu- rons (including those that project ...
[62]
Dopamine D1/D5 receptor modulation of excitatory synaptic ... - PNAS
Dopamine acts mainly through the D1/D5 receptor in the prefrontal cortex (PFC) to modulate neural activity and behaviors associated with working memory.
[63]
Norepinephrine versus Dopamine and their Interaction in ...
This review summarizes previous studies that investigated the effects of both NE and DA on excitatory and inhibitory transmissions in the prefrontal cortical ...
[64]
Inverted-U shaped dopamine actions on human working memory ...
Manipulating dopamine will thus have paradoxical consequences for distinct cognitive control processes depending on distinct basal or optimal levels of dopamine ...
[65]
Dopamine and working memory mechanisms in prefrontal cortex - NIH
They show that in intact deep layer PFC pyramidal neurons, dopamine, acting at surface D1 receptors, diminishes active temporal 'stretching' of excitatory ...
[66]
Irrelevant stimulus processing in ADHD: catecholamine dynamics ...
For example, the ADHD-risk DRD4-7R polymorphism has been proposed to be a hypofunctional form that blunts tonic dopaminergic signaling in the prefrontal cortex.
[67]
Prefrontal dopamine and behavioral flexibility: shifting from an ...
Apr 18, 2013 · When viewed collectively, these findings suggest that the “inverted-U” shaped dose-response curve underlying D1 receptor modulation of working ...
[68]
Dopamine D1 receptors in the anterior cingulate cortex regulate ...
Prefrontal DA plays an essential role in cognitive processes and regulates aspects of working memory and attention through actions on D1 receptors (e.g., Granon ...
[69]
Investing in the Future: Stimulation of the Medial Prefrontal Cortex ...
In particular, discounting level interacted with striatal dopamine displacement, and participants who showed preferences toward future rewards tended to occupy ...
[70]
Differential Contributions of Prefrontal and Hippocampal Dopamine ...
Nov 12, 2008 · We found an inverted U-shaped relation between prefrontal D1 receptor binding and Wisconsin Card Sorting Test performance. However, prefrontal D ...
[71]
Prolactin and dopamine: what is the connection? A review article
Dopamine (DA) holds a predominant role in the regulation of prolactin (PRL) secretion. Through a direct effect on anterior pituitary lactotrophs, DA inhibits ...
[72]
Dopamine Inhibits Basal Prolactin Release in Pituitary Lactotrophs ...
Dec 20, 2007 · Dopamine inhibits basal PRL release by blocking voltage-gated Ca 2+ influx through the PTX-sensitive signaling pathway and by desensitizing Ca 2+ secretion ...
[73]
The Mechanism and Pathways of Dopamine and ... - Frontiers
Jan 21, 2019 · The lactotroph adenoma cells express dopamine receptors, and DAs effectively suppress prolactin secretion and shrink the tumor by binding the ...
[74]
Sympathoadrenal Hyperactivity and the Etiology of Neuroleptic ...
These tonic inhibitory inputs are relayed to preganglionic sympathetic neurons by way of dopaminergic hypothalamospinal tracts. The sympathetic nervous system ...
[75]
Renal dopaminergic system: Pathophysiological implications and ...
Core tip: Renal dopaminergic system is a local and independent natriuretic system necessary to maintain the normal balance of sodium and water, blood pressure ...Missing: seminal | Show results with:seminal
[76]
Dopamine and Renal Function and Blood Pressure Regulation - PMC
The kidney synthesizes dopamine from circulating or filtered l-DOPA independently from innervation. The major determinants of the renal tubular synthesis/ ...
[77]
Dopamine: A Modulator of Circadian Rhythms in the Central ...
This review focuses on five of those brain areas: the retina, OB, striatum, midbrain, and hypothalamus (See Supplementary Table 1). Dopamine is a well-known ...
[78]
Dopamine systems and biological rhythms: Let's get a move on
How dopamine signaling regulates biological rhythms is an area of emerging interest. Here we review experiments focused on delineating dopamine signaling in ...Abstract · Introduction · Food as a zeitgeber · Conclusion
[79]
The Emergence of Gonadal Hormone Influences on Dopaminergic ...
Gonadal steroids may influence the morphology of dopaminergic neurons as well as expression of key dopaminergic proteins and afferent regulation of dopamine ...
[80]
Steroids‐Dopamine Interactions in the Pathophysiology and ...
Sex steroid hormones influence DA systems of the hypothalamus as well as extrahypothalamic regions of the brain in controlling movement and behavior in humans ...<|control11|><|separator|>
[81]
Renal Dopamine System | Hypertension
Although the classical pathway for dopamine biosynthesis occurs in neurons, in the kidney dopamine is synthesized independently of nerve activity. Dopamine ...Missing: synthesis | Show results with:synthesis
[82]
Neuromicrobiology, an emerging neurometabolic facet of the gut ...
Although the brain is the main site of dopamine synthesis, enteric neurons and intestinal epithelial cells produce approximately 50% of total dopamine in the ...Microbiota-produced... · Impact of neuroactive... · Transport mechanisms of gut...
[83]
Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic ...
Emerging evidence shows that gut microbiota have significant roles in maintaining adequate concentrations of dopamine via intricate, bidirectional ...
[84]
AMPA and NMDA Glutamate Receptor Subunits in Midbrain ...
The glutamatergic inputs to SNc and VTA arise from four major sources: the cerebral cortex, the subthalamic nucleus, the pedunculopontine nucleus, and the ...Missing: PFC | Show results with:PFC
[85]
Pedunculopontine glutamatergic neurons control spike patterning in ...
Oct 5, 2017 · Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior.
[86]
Inhibition of Nigrostriatal Dopamine Release by Striatal GABAA and ...
Feb 6, 2019 · These results indicate that striatal GABA can inhibit DA release through GABA A and GABA B receptors and that these actions are not mediated by cholinergic ...
[87]
GABA uptake transporters support dopamine release in dorsal ...
Oct 2, 2020 · Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA.
[88]
Serotonin 5-HT2 Receptor Interactions with Dopamine Function
Extensive research suggests that the primary contribution of 5-HT to cocaine addiction is a consequence of interactions with dopamine (DA) neurotransmission.
[89]
5-HT2A and 5-HT2C Receptors Exert Opposing Effects on ... - Nature
Mar 25, 2009 · These results show for the first time that 5-HT 2A and 5-HT 2C receptors both contribute to the effects of DOI on locomotor activity in mice.
[90]
Estrogens in schizophrenia: progress, current challenges and ...
In the CNS, estrogens increase the sensitivity of dopamine D2 receptors and thus they augment the efficacy of (D2-receptor binding) antipsychotics [88,89].
[91]
Increased Dopamine Receptor Sensitivity After Estrogen Treatment ...
Estrogen treatment resulted in a corresponding increase in the number of striatal dopamine receptors. Therefore, both behavioral and biochemical evidence ...
[92]
Corticotropin-releasing factor increases mouse ventral tegmental ...
Stress induces the release of the peptide corticotropin-releasing factor (CRF) into the ventral tegmental area (VTA), and also increases dopamine levels in ...
[93]
Distinct Temporal Structure of Nicotinic ACh Receptor Activation ...
... cholinergic input onto VTA neurons is crucial for DA neuron burst firing. The number of these afferent neurons converging on each VTA neuron is not known.
[94]
Hierarchical Control of Dopamine Neuron-Firing Patterns by ...
Nicotine elicits dopamine release by stimulating nicotinic acetylcholine receptors (nAChRs) on dopaminergic neurons.
[95]
Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain ...
This study shows that two regulatory loops (Wnt1-Lmx1a and SHH-FoxA2) critically link extrinsic signals to cell-intrinsic factors and cooperatively regulate ...
[96]
Development of the dopaminergic neurons in the rodent brainstem
The loss of dopaminergic (DA) neurons in the ventral midbrain is the principal cause of Parkinson's disease. The search for candidate molecules that promote ...<|control11|><|separator|>
[97]
The Role of Transcription Factor Pitx3 in Dopamine Neuron ...
Pitx3 is required for the survival of some terminally differentiating SNc DA neurons [7]. There is likely interaction between Nurr1 and Pitx3, with evidence ...
[98]
Pitx3 is required for motor activity and for survival of a subset of ...
Jun 1, 2003 · Thus, Pitx3 defines a pathway for survival of neurons that are implicated in PD and that are required for spontaneous locomotor activity.Pitx3 Serves A Maintenance... · Striatal Dopamine Deficiency · Pitx3 And Neurodegeneration...
[99]
The essential role of transcription factor Pitx3 in preventing ... - Nature
Oct 27, 2021 · Pituitary homeobox 3 (Pitx3) is required for the terminal differentiation of nigrostriatal dopaminergic neurons during neuronal development.
[100]
Migratory defect of mesencephalic dopaminergic neurons in ...
In this study, reelin-deficient reeler mice exhibited a significant loss of mDA neurons in the substantia nigra pars compacta (SNc) and a severe alteration of ...Missing: rodents | Show results with:rodents
[101]
Single-cell transcriptional and functional analysis of dopaminergic ...
We accessed human embryos at the stage when the DA neurons in the ventral midbrain arise, ranging from weeks 6 to 11 post-conception (PC) (Fig. 1A, Table S1).Missing: timeline | Show results with:timeline
[102]
Single-cell transcriptional and functional analysis of dopaminergic ...
Summary: A unique transcriptional profile of the developing human fetal VM and functionally mature human DA neurons that can be used to guide stem.
[103]
Neurobehavioral Evidence for Changes in Dopamine System ...
Aug 26, 2009 · Although axonal length and varicosities peak during adolescence in all three areas, important differences occur between cortical layers.
[104]
Increased Vesicular Monoamine Transporter 2 (VMAT2) and ...
Jan 15, 2019 · Background: Brain development and maturation in adolescence is a complex process with active changes of metabolic and neurotransmission pathwaysMissing: axonal | Show results with:axonal
[105]
Adolescence and Reward: Making Sense of Neural and Behavioral ...
Nov 8, 2017 · As mentioned above, innervation of the PFC by dopaminergic neurons from the VTA occurs during adolescence. Reynolds et al. (2017) recently ...
[106]
Prenatal and postnatal alcohol exposure increases vulnerability to ...
Nov 8, 2019 · Prenatal ethanol exposure alters the postnatal development of the spontaneous electrical activity of dopamine neurons in the ventral tegmental ...
[107]
Sex Differences in Dopamine Receptors and Relevance to ...
Sep 11, 2021 · As previously mentioned, male mice exhibited a more prominent increase in dopamine D1 and D2 receptors early on in development, and a more rapid ...
[108]
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned ...
LTP/LTD induction is often mirrored by bidirectional postsynaptic trafficking of AMPA receptors mediated in part by changes in scaffolding protein association ...
[109]
Psychostimulant-Induced Neuroadaptations in Nucleus Accumbens ...
Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaine. Neurotox Res 18: 393–409 [DOI] [PMC free article] [PubMed] [Google ...
[110]
Endocannabinoid-mediated synaptic plasticity and addiction-related ...
Intracellular trafficking of anandamide: new concepts for signaling. Trends ... cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens ...
[111]
Astrocyte regulation of synaptic signaling in psychiatric disorders
However, gliotransmission of adenosine binds to A2A receptors and interacts directly with D2-dopamine receptors to dampen the effects of dopamine release, with ...
[112]
Astrocytes—The Ultimate Effectors of Long-Range Neuromodulatory ...
Sep 29, 2020 · Volume transmission in central dopamine and noradrenaline neurons and its astroglial targets. Neurochem. Res. 40, 2600–2614. 10.1007/s11064 ...
[113]
Neurobehavioral Effects of Environmental Enrichment and Drug ...
For example, at the cell body, environment enrichment does not alter basal firing of dopamine neurons in the VTA (Zhu and Grace, 2021)]. In addition, at the ...
[114]
Chronic Stress Induces Contrasting Patterns of Dendritic ...
These results indicate that chronic stress can cause contrasting patterns of dendritic remodeling in neurons of the amygdala and hippocampus.
[115]
Regulation of BDNF-TrkB Signaling and Potential Therapeutic ...
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase receptor type B (BDNF/TrkB) signaling supports neuronal survival, plasticity, ...
[116]
Alpha-Synuclein as a Prominent Actor in the Inflammatory ...
α-Synuclein Induces Synaptic Dysfunction. In PD, synaptic dysfunction precedes neurodegeneration, and in the last twenty years, research has focused on ...
[117]
Redefining dopaminergic synapses beyond the classical paradigm
Oct 15, 2025 · ... dopamine vesicles, revealing a structural continuum that includes non-classical architectures. ... The coexistence of these two release modes ...
[118]
Modeling Parkinson's Disease With the Alpha-Synuclein Protein
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol ...
[119]
α-Synuclein in Parkinson's Disease - PMC - PubMed Central
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration. Mol Ther 18: 1450–1457 [DOI] [PMC free article] [PubMed] [Google Scholar] ...
[120]
Pathophysiology of Huntington's Disease: Time-Dependent ...
This would indicate that in HD biphasic changes in DA function may occur, with early increases followed by late decreases. Overactivity in the nigrostriatal ...2.1 Striatum · 8 Role Of Nmdars In Hd · 8.1 Altered Nmdar Activity...Missing: hypersensitivity | Show results with:hypersensitivity
[121]
Dopamine imbalance in Huntington's disease: a mechanism for the ...
Alterations in DA balance in the striatum lead to pathological conditions such as Parkinson's and Huntington's diseases (HD).Dopamine Imbalance In... · Striatal Organization · Da In Animal Models Of Hd
[122]
Restless Legs Syndrome: From Pathophysiology to Clinical ...
Jun 1, 2017 · Recent studies have suggested an important role of iron decrease of brain in RLS pathophysiology. Dopaminergic (DA) system dysfunction in A11 ...
[123]
Possible Sites of Therapeutic Action in Restless Legs Syndrome
Jun 28, 2011 · The hypothalamic A11 dopaminergic circuit is used to explain the dopamine dysfunction in RLS and the potential therapeutic actions of dopamine ...Abstract · Introduction · Potential Therapeutic Sites of... · Mechanistic Appraisal of...
[124]
The direct basal ganglia pathway is hyperfunctional in focal dystonia
Oct 26, 2017 · Collectively, these aberrations of striatal dopaminergic function underlie imbalance between direct and indirect basal ganglia pathways and lead ...
[125]
Dystonia and dopamine: From phenomenology to pathophysiology
Dystonia's pathophysiology involves the striatum, modulated by dopamine, which regulates the balance between striato-pallidal pathways. The link is complex and ...Review Article · 5. Dystonia Associated With... · 7. Dystonia Unresponsive To...
[126]
Levodopa (L-Dopa) - StatPearls - NCBI Bookshelf - NIH
Apr 17, 2023 · Levodopa is the precursor to dopamine. Most commonly, clinicians use levodopa as a dopamine replacement agent for the treatment of Parkinson disease.Continuing Education Activity · Indications · Administration · Adverse Effects
[127]
Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson ...
Sep 15, 2025 · This cohort study evaluates 5-year outcomes and safety of subthalamic nucleus deep brain stimulation for the treatment of Parkinson disease.
[128]
A nanoparticle-based wireless deep brain stimulation system that ...
Jan 15, 2025 · We describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine neurons.
[129]
Interrelations between dopaminergic-, gabaergic- and glutamatergic ...
Sep 12, 2025 · Preclinical evidence points to disturbances in neural networks in psychosis involving interrelations between dopaminergic-, GABAergic- and ...
[130]
Glutamate and dopamine in schizophrenia: An update for the 21st ...
Aug 7, 2025 · predominantly a model of psychosis in schizophrenia. Cognitive and negative symptoms of schizophrenia are. responsible for a major proportion of ...
[131]
The dopamine hypothesis for ADHD: An evaluation of evidence ...
Multiple lines of evidence indicate that altered dopamine signaling may be involved in neuropsychiatric disorders and common behavioral traits.
[132]
DRD4 and DAT1 in ADHD: Functional neurobiology to ...
DRD4 and DAT1 polymorphisms are interesting candidates for pharmacogenetic studies. DAT1 has the best evidence but the specific genotype associated with greater ...
[133]
Association between Dopamine Transporter (DAT1) Genotype, Left ...
Aug 3, 2005 · Our results suggest a subgroup of children with ADHD for whom the 10-repeat DAT1 allele is associated with left-sided inattention.Missing: mesocortical | Show results with:mesocortical
[134]
Liking, Wanting and the Incentive-Sensitization Theory of Addiction
Incentive salience or 'wanting', a form of motivation, is generated by large and robust neural systems that include mesolimbic dopamine. By comparison, 'liking' ...
[135]
Dopamine and Addiction - Annual Reviews
Jan 4, 2020 · As a result of habitual intake of addictive drugs, dopamine receptors expressed in the brain are decreased, thereby reducing interest in ...
[136]
Dopamine System Dysregulation in Major Depressive Disorders
Anhedonia is considered a core feature of major depressive disorder, and the dopamine system plays a pivotal role in the hedonic deficits described in this ...
[137]
Dopamine D1 receptor agonist alleviates post-weaning isolation ...
Mar 10, 2025 · This study highlights a sex-specific susceptibility to PWI-induced neuroinflammation and depression. While targeting the D1R shows potential in alleviating PWI ...
[138]
Optogenetic stimulation of ventral tegmental area dopaminergic ...
Jan 28, 2022 · In this study, we hypothesized that stimulating VTA DA neurons at the mfb cause anxiolytic and antidepressant effects. In addition, we ...2 Methods · 3 Results · 4 Discussion
[139]
Dopamine-mediated autocrine inhibition of insulin secretion
Oct 1, 2024 · Dopamine significantly inhibits insulin secretion stimulated by both glucose and other secretagogues, while it has no effect on the basal secretion.
[140]
Striatal astrocytes modulate behavioral flexibility and whole-body ...
Jul 7, 2025 · This work reveals a yet unappreciated role for striatal astrocytes as a direct operator of flexible behavior and metabolic control.
[141]
Dopamine System Dysfunction in Alzheimer's Disease - PMC
Sep 8, 2025 · We review the knowledge of the dopaminergic system, emphasizing changes in Alzheimer's disease.
[142]
Modulation of T-cell Mediated Immunity by Dopamine Receptor d5
Several studies have shown that dopamine, not only mediates interactions into the nervous system, but it can also contribute to the modulation of immunity. Here ...
[143]
Dopamine Receptor D5 Signaling Plays a Dual Role in ...
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive ...