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Birthmark

A birthmark is a benign skin discoloration or lesion present at birth or appearing shortly thereafter, often differing in color, size, shape, or texture from the surrounding skin.^[1] These marks are common, affecting approximately 20-30% of newborns with vascular types such as salmon patches and hemangiomas, and varying widely in prevalence for pigmented types, such as 1 in 100 for congenital nevi.^[1]^[2] Most birthmarks are harmless and fade over time, though some may persist, grow, or signal underlying conditions requiring medical attention.^[3] Birthmarks are broadly categorized into two main types: vascular and pigmented. Vascular birthmarks arise from abnormalities in blood vessel formation, leading to reddish, pink, or purplish discolorations; examples include infantile hemangiomas (strawberry marks), which are raised clusters of blood vessels that typically appear in the first few weeks of life and often involute by age 10, and port-wine stains, flat pink-to-purple marks caused by dilated capillaries that may darken or thicken with age.^[1]^[3] Pigmented birthmarks, in contrast, result from overgrowth of pigment-producing cells (melanocytes), manifesting as brown, tan, black, or blue-gray spots; common subtypes are café-au-lait spots (light brown, coffee-with-milk-colored patches that are usually permanent) and Mongolian spots (blue-gray patches on the lower back or buttocks, which fade in early childhood and are more prevalent in children of Asian, Black, Hispanic, or Native American descent).^[3] The exact causes of birthmarks remain largely unknown, but they are thought to stem from errors in the development of blood vessels or melanocytes during fetal growth, potentially influenced by genetic factors.^[1] They cannot be prevented, and while most pose no health risks, certain types carry notable implications: large congenital nevi (pigmented moles greater than 20 cm) increase the risk of melanoma, and vascular birthmarks like port-wine stains may be associated with syndromes such as Sturge-Weber, involving neurological issues.^[3]^[1] Diagnosis typically involves a physical examination by a dermatologist, with imaging like ultrasound or MRI used if deeper involvement is suspected, and biopsy for suspicious changes.^[1] Treatment is often unnecessary, as many birthmarks resolve spontaneously, but for hemangiomas requiring intervention, beta-blocker medications (e.g., propranolol) may be used early during the proliferative phase; options for cosmetic concerns, functional impairments, or complications, such as laser therapy to lighten vascular marks like port-wine stains or surgical excision for pigmented lesions at higher cancer risk, are typically considered after infancy (age 6 or older).^[3]^[1]^[4] Potential side effects of interventions include scarring, pigmentation changes, or infection, and psychological support may be beneficial for visible birthmarks affecting self-esteem.^[1] Overall, birthmarks highlight the diversity of skin development and underscore the importance of monitoring for rare associated health concerns.

Overview

Definition and Characteristics

A birthmark is a congenital or early-appearing benign skin lesion resulting from the abnormal proliferation or development of pigment-producing cells (melanocytes), blood vessels, or other skin components such as fat, fibroblasts, or smooth muscle.^[5]^[6] These lesions are typically present at birth, though some may emerge within the first few weeks of life, and they represent developmental anomalies rather than pathological conditions in most cases.^[3] Birthmarks exhibit diverse characteristics, including variations in color—ranging from pink and red (due to vascular involvement) to brown, black, tan, gray, or blue (from pigment accumulation)—as well as differences in size, which can span from tiny spots to extensive patches covering large body areas.^[6]^[5] They may appear flat and level with the skin surface or raised and textured, with irregular or well-defined shapes, and can occur on any body part, including the face, trunk, limbs, or even mucous membranes inside the mouth.^[6] Most birthmarks are harmless, non-painful, and stable over time, though some may grow proportionally with the child, fade spontaneously, or rarely cause complications like ulceration or bleeding.^[3]^[5] In contrast to acquired skin markings, such as bruises from trauma—which are temporary, resolve without intervention, and result from extravasated blood—or intentional tattoos, birthmarks are innate and do not arise from external injury or artificial means.^[5]^[6] From an embryological perspective, birthmarks originate from disruptions in fetal development, particularly the abnormal migration, proliferation, or differentiation of melanocytes derived from neural crest cells or the faulty formation of vascular networks during vasculogenesis and angiogenesis in utero.^[7] Broadly, they fall into pigmented types involving excess melanocytes and vascular types stemming from aberrant blood vessel growth, though other structural anomalies may contribute.^[5]

Prevalence and Epidemiology

Birthmarks are among the most common cutaneous findings in newborns, with vascular birthmarks affecting 20-30% of neonates overall.^[8] Among these, nevus simplex (commonly known as salmon patches) is particularly prevalent, occurring in 30-40% of infants, while infantile hemangiomas have an incidence of 4-5%.^[9]^[10] Port-wine stains are rarer, with a prevalence of 0.3-0.5% in the general population.^[11] Pigmented birthmarks other than dermal melanocytosis are less frequent, appearing in 1-3% of newborns, including congenital melanocytic nevi at 1-2% and café au lait spots in varying proportions depending on ethnicity.^[12]^[13] Demographic variations significantly influence birthmark occurrence. Dermal melanocytosis (Mongolian spots) shows marked ethnic differences, affecting up to 90% of Asian, African, and Hispanic infants but fewer than 10% of white infants.^[14] Solitary café au lait spots are also more common in non-white populations, present in 18% of black newborns compared to 0.3% of white newborns.^[15] Globally, there are no substantial sex differences for most birthmarks, though infantile hemangiomas exhibit a female predominance with a 3:1 ratio.^[16] Many birthmarks exhibit age-related changes, with spontaneous resolution common in certain types. For instance, most salmon patches on the face resolve by age 1-2 years, though nuchal salmon patches persist in about 25-50% of cases; most Mongolian spots fade by school age.^[9] In contrast, port-wine stains and congenital melanocytic nevi typically persist lifelong without regression.^[11] Recent epidemiological data for infantile hemangiomas indicate an increase in incidence, correlated with decreasing gestational age at birth and birth weight as of 2010.^[17]

Causes and Pathophysiology

Genetic and Developmental Factors

Birthmarks, also known as congenital skin lesions, primarily arise from sporadic somatic mutations rather than germline inheritance, with most cases resulting from postzygotic genetic changes during embryonic development.^[18] For pigmented birthmarks, such as congenital melanocytic nevi, activating mutations in the NRAS gene are frequently identified, particularly in larger lesions, leading to uncontrolled proliferation of melanocytes.^[19] Similarly, vascular birthmarks like port-wine stains are commonly associated with somatic mutations in the GNAQ gene, which disrupt G-protein signaling and contribute to abnormal capillary development, often linked to syndromes such as Sturge-Weber.^[20] These mutations are mosaic, affecting only specific cell lineages, which explains the localized nature of the lesions.^[18] Developmentally, birthmarks stem from disruptions in embryonic processes, particularly errors in the migration and differentiation of neural crest-derived cells. In pigmented types, aberrant migration of melanocyte precursors from the neural crest results in their clustering within the dermis or epidermis, as seen in conditions like dermal melanocytosis or Mongolian spots.^[21] For vascular birthmarks, malformations arise from faulty assembly of the vascular plexus during vasculogenesis and angiogenesis, often involving neural crest contributions to vessel wall components, leading to persistent dilated capillaries or aberrant vessel formation.^[22] These developmental anomalies typically occur early in gestation, highlighting the role of timing in somatic mutation acquisition. Inheritance of birthmarks is rare, with the vast majority being non-hereditary due to their somatic origin; polygenic factors may influence susceptibility, but transmission risk remains low, estimated at less than 5% for familial clustering in melanocytic nevi.^[19] Autosomal dominant patterns are observed in select familial vascular birthmarks, but these represent exceptions rather than the norm.^[23] Recent genetic research through 2025 has advanced understanding of these mechanisms, with studies refining the role of NRAS and GNAQ mosaicism in overlapping pigmentovascular phenotypes, supporting precision diagnostics.^[20] The PI3K/AKT/mTOR pathway plays a role in various vascular anomalies, paving the way for targeted therapies like mTOR inhibitors.^[22] Environmental factors may modulate these genetic predispositions, but intrinsic developmental errors predominate.^[7]

Environmental Influences

Prenatal exposures during pregnancy have been linked to an increased risk of vascular birthmarks, particularly infantile hemangiomas. Low birth weight and preterm birth are significant risk factors, with studies indicating that infants weighing less than 1 kg at birth have a 22% to 30% incidence of hemangiomas, compared to lower rates in term infants.^[24] For every 500 g decrease in birth weight, the risk of infantile hemangioma increases by approximately 40%.^[25] Maternal smoking during pregnancy has shown a positive association with hemangiomas in some cohort studies, potentially due to nicotine's effects on fetal vascular development.^[26] Certain medications, such as progesterone used for preterm labor prevention and beta-2 sympathomimetics, have been associated with elevated hemangioma risk, with odds ratios up to 2.9-fold in exposed groups.^[27]^[28] Hormonal influences, particularly estrogen surges during pregnancy, may contribute to the postnatal proliferation of hemangiomas. Elevated estrogen levels are believed to promote vascular endothelial growth, leading to rapid hemangioma expansion in the early months after birth, though the exact mechanism remains under investigation.^[29]^[30] This hormonal effect is more pronounced in conditions like pregnancy or estrogen therapy, where hemangiomas can enlarge due to stimulated angiogenesis.^[31] Postnatal environmental factors play a limited role in the formation of congenital birthmarks but can influence their appearance. Ultraviolet (UV) exposure does not cause new congenital marks but can darken existing pigmented birthmarks, such as café au lait spots or congenital melanocytic nevi, by stimulating melanin production in response to sun damage.^[1] There is no strong evidence linking maternal diet or infections directly to birthmark development, as these factors primarily affect other congenital anomalies rather than vascular or pigmented lesions.^[32]

Classification

Pigmented Birthmarks

Pigmented birthmarks are skin lesions present at birth or appearing shortly thereafter, arising from the proliferation of melanocytes or increased deposition of melanin in the skin. These marks manifest as areas of hyperpigmentation, with colors typically ranging from light brown to black, influenced by the depth and density of the melanin. Unlike vascular birthmarks, which stem from blood vessel malformations, pigmented birthmarks result exclusively from melanin-related alterations.^[9]^[33]^[34] These birthmarks are generally flat and benign, often enlarging proportionally with the child's growth without causing symptoms. Most do not require intervention and pose no health risks, though larger variants, such as extensive congenital melanocytic nevi, necessitate ongoing monitoring due to a potential risk of malignant transformation into melanoma, estimated at 4-6% for those exceeding 20 cm in adulthood.^[9]^[34]^[33] Pigmented birthmarks are subclassified by pigment location: epidermal types feature melanin in the superficial skin layers, yielding tan to brown hues, while dermal types involve deeper deposition, producing blue-gray appearances due to the Tyndall effect. For instance, café au lait spots exemplify epidermal involvement, and Mongolian spots represent dermal forms.^[9]^[34] Histologically, these lesions exhibit an increased density of melanocytes or heightened melanin content in keratinocytes and dermal melanophages, without inflammatory changes or other pathological features. This excess pigment arises from developmental anomalies in melanocyte migration or function during embryogenesis.^[9]^[34]

Vascular Birthmarks

Vascular birthmarks, also referred to as vascular anomalies, are congenital lesions resulting from malformations or abnormal proliferations of blood vessels, including capillaries, veins, or arteries. These anomalies typically appear as pink, red, or purple discolorations on the skin, varying in shade and texture based on the depth and extent of vascular involvement.^[23] They occur in approximately 40% of newborns and represent errors in vascular development rather than mere cosmetic variations.^[23] A distinguishing characteristic of vascular birthmarks is their tendency to blanch (turn pale) when gentle pressure is applied, reflecting the underlying dilated blood vessels filled with blood. These lesions can be prone to complications such as ulceration, particularly in areas subject to friction, and bleeding, which may occur spontaneously or with minor trauma. Some vascular birthmarks, especially those classified as tumors, demonstrate a natural involution process, gradually regressing over months to years without intervention.^[35]^[8] The International Society for the Study of Vascular Anomalies (ISSVA) provides the standard classification framework, dividing vascular anomalies into tumors—benign proliferative growths—and malformations, which are non-neoplastic structural abnormalities present at birth. Malformations are subclassified as simple, involving a single vessel type (e.g., capillary macular stains or venous malformations), or complex/associated, involving multiple vessel types (e.g., arteriovenous malformations, or AVMs). Further categorization distinguishes infantile proliferative lesions from congenital static malformations, with additional grouping by hemodynamic properties into slow-flow (capillary, venous, lymphatic) and fast-flow (arterial, arteriovenous) types. The 2025 ISSVA update refines these categories to include emerging molecular subtypes and borderline tumors, enhancing diagnostic precision.^[36]^[37] At the pathophysiological level, vascular birthmarks arise from dysregulated angiogenesis, the formation of new blood vessels from pre-existing ones, leading to immature or excessive vascular networks. The vascular endothelial growth factor (VEGF) pathway is centrally involved, promoting endothelial cell proliferation and migration in these anomalies. Recent insights, including 2025 genetic studies, underscore somatic mutations in VEGF signaling components as key drivers in subtypes like infantile hemangiomas and certain malformations, influencing vessel maturation and stability.^[38]^[39]

Other Types

Epidermal nevi represent hamartomatous overgrowths of epidermal structures, manifesting as localized proliferations of skin cells present at birth or early infancy.^[40] These lesions typically appear as linear or plaque-like arrangements, often following the lines of Blaschko, and may exhibit a pink to hyperpigmented coloration that can evolve into verrucous surfaces over time.^[41] While generally benign, epidermal nevi can occasionally associate with epidermal nevus syndrome, necessitating evaluation for systemic involvement.^[42] Congenital hairy nevi, also known as giant congenital melanocytic nevi when extensive, are rare pigmented lesions characterized by large, irregular patches covered in coarse hair, often exceeding 20 cm in diameter in adulthood.^[43] These hamartomas arise from disordered melanocyte proliferation during fetal development and carry an elevated lifetime risk of malignant transformation to melanoma, estimated at up to 5% for larger variants.^[44] Although they overlap with pigmented birthmark categories due to their melanocytic origin, their prominent hypertrichosis distinguishes them in atypical presentations. Becker's nevus is a benign hamartomatous condition featuring a hyperpigmented, irregularly bordered patch with overlying hypertrichosis, typically emerging during adolescence but tracing to congenital epidermal origins.^[45] Unlike more common nevi, it remains asymptomatic and non-malignant, with no routine need for intervention beyond cosmetic concerns.^[46] Collectively, these other types constitute less than 1% of all birthmarks, with epidermal nevi occurring in approximately 1 in 1,000 live births.^[47] Their evaluation often requires multidisciplinary input from dermatologists, geneticists, and pediatric specialists to assess for potential complications. Recent genetic studies as of 2025 have identified postzygotic HRAS mutations as key drivers in many epidermal nevi, offering insights into their mosaic pathogenesis and potential targeted therapies.^[48]

Specific Pigmented Types

Moles (Congenital Melanocytic Nevi)

Congenital melanocytic nevi (CMN), commonly referred to as moles, are benign skin lesions present at birth resulting from the proliferation of nests of melanocytes in the epidermis, dermis, or both layers. These lesions typically appear as well-defined, round or ovoid brown to black macules or papules, though larger ones may exhibit irregular borders, varied pigmentation, and a cobblestoned or pebbly texture. CMN are classified by their projected adult size: small (<1.5 cm), medium (1.5–19.9 cm), and large or giant (≥20 cm), with giant lesions often covering extensive areas and being more cosmetically and medically challenging.^[49]^[13]^[50] Key characteristics of CMN include the potential for hypertrichosis, or excess hair growth, observed in approximately 75% of cases, particularly in larger nevi. Giant CMN frequently feature satellite lesions—smaller pigmented spots nearby—in up to 80% of instances, and they may evolve with increased nodularity or pigmentation changes over time. The lifetime risk of malignant transformation to melanoma is low for small and medium CMN (0–4.9%), but rises significantly for giant variants (1.25–10%), with poorer prognosis if melanoma develops within the nevus. Additionally, large CMN carry a 5–10% risk of neurocutaneous melanosis, a rare syndrome involving melanocytic proliferation in the central nervous system that can manifest as seizures, hydrocephalus, or other neurological symptoms.^[49]^[13]^[49] CMN generally grow proportionally to the child's body size, with regional growth factors influencing expansion (e.g., 1.7-fold on the head versus 3.3-fold on the lower limbs). Monitoring is essential, especially for larger lesions, and involves regular clinical examinations using the ABCDE criteria—asymmetry, border irregularity, color variation, diameter >6 mm, and evolution—to detect any changes suggestive of malignancy. Baseline photography and dermoscopy aid in tracking alterations, with biopsy recommended if suspicious features emerge.^[49]^[51]^[13]

Café au Lait Spots

Café au lait spots, also known as café au lait macules, are benign, hyperpigmented skin lesions characterized by well-circumscribed, oval or irregular macules or patches with a light to dark brown coloration resembling coffee with milk.^[52] These lesions typically feature smooth, regular borders often described as having the "coast of California" appearance, distinguishing them from more irregular variants.^[53] They are usually flat, uniform in color, and range in size from a few millimeters to over 20 cm, most commonly appearing on the trunk and extremities.^[15] In the general population, one to six café au lait spots are considered common and benign, with no malignant potential and no need for intervention unless associated with a syndrome.^[53] However, the presence of six or more spots, particularly those larger than 5 mm in diameter before puberty or 15 mm after puberty, is a key diagnostic criterion for neurofibromatosis type 1 (NF1), a genetic disorder affecting approximately 1 in 3,500 individuals.^[52] These spots are observed in about 95% of NF1 patients and often serve as the earliest clinical sign, prompting genetic evaluation.^[15] They may also appear in other rare genetic conditions, such as McCune-Albright syndrome, but NF1 remains the primary association warranting further investigation when multiple lesions are present.^[53] Café au lait spots have a prevalence of 10-20% in the general population, with solitary lesions occurring in 0.3% of white newborns and up to 18% of Black newborns, increasing to 13% in white children and 27% in Black children by school age.^[53] They are typically present at birth or emerge during early infancy, becoming more noticeable by age 2, and show no sex predilection, though they are more frequent in individuals with darker skin tones.^[15] Histologically, café au lait spots exhibit increased melanin pigmentation confined to the basal layer of the epidermis, with normal numbers of melanocytes but enhanced melanin production in basal keratinocytes and melanocytes.^[54] In cases associated with NF1, giant melanosomes may be present within melanocytes, contributing to the hyperpigmentation, though the overall architecture remains unchanged from normal skin.^[52]

Mongolian Spots (Congenital Dermal Melanocytosis)

Mongolian spots, also known as congenital dermal melanocytosis, are benign, flat, hyperpigmented macules resulting from the presence of melanocytes in the deeper layers of the dermis, which scatter light to produce a characteristic blue-gray coloration.^[55] These lesions typically appear at birth or shortly thereafter and are most commonly located on the lower back, buttocks, and sacral region, though they can occasionally extend to the flanks, shoulders, or proximal extremities.^[55] The pigmentation arises from mature melanocytes trapped in the dermis during fetal development, without proliferation or atypia.^[55] They are particularly prevalent among individuals of certain ethnic backgrounds, occurring in 81-100% of Asian infants, 95.5-96% of Black infants, 46.3-70.1% of Hispanic infants, and only about 9.6% of White infants.^[55] The spots are usually solitary or multiple, ranging from a few centimeters to covering large areas, and present as round, oval, or irregular patches that feel no different from surrounding skin to the touch.^[55] In most cases, these lesions fade gradually due to the migration of melanocytes or pigment dispersion, resolving completely by age 1 to 6 years, though larger, darker, or extra-sacral spots may persist longer or rarely into adulthood.^[55] A notable clinical consideration is the potential misdiagnosis of Mongolian spots as non-accidental trauma or bruising, particularly in children of non-Asian descent, which underscores the importance of documenting these findings at birth to prevent unnecessary child protection investigations.^[55] Extensive variants, where spots cover much of the trunk and limbs, are uncommon but can signal underlying conditions such as GM1 gangliosidosis, a lysosomal storage disorder caused by GLB1 gene mutations leading to abnormal glycosphingolipid accumulation.^[56] In such cases, the widespread dermal melanocytosis serves as an early diagnostic clue, prompting further evaluation for metabolic diseases.^[57]

Specific Vascular Types

Salmon Patches (Stork Bites)

Salmon patches, also known as stork bites or nevus simplex, are common vascular birthmarks characterized by flat, pink to red macular patches resulting from dilated capillaries near the skin's surface.^[58]^[59] These lesions appear as irregular, non-palpable areas with indistinct, feathery borders, often salmon-colored due to telangiectasias in the dermis, and are visible through the thin skin of newborns.^[9] They typically present at birth and are caused by immaturity or enlargement of superficial blood vessels that developed during fetal stages.^[60] These birthmarks occur in 30% to 50% of newborns, making them the most prevalent type of vascular birthmark.^[9]^[59] Common locations include the nape of the neck, forehead (glabella), upper eyelids, and occasionally the scalp or lower back.^[58]^[60] Salmon patches often blanch (pale) when gentle pressure is applied, demonstrating their superficial vascular nature, but they may become more prominent or deepen in color during crying, straining, or changes in temperature due to increased blood flow.^[9]^[61] Most resolve spontaneously without intervention: approximately 95% of facial lesions fade by age 1 to 2 years, while nape lesions are more persistent, with about 50% remaining into adulthood.^[59]^[58] Salmon patches are entirely benign and require no medical treatment unless they cause cosmetic concerns in persistent cases.^[9]^[60] They pose no health risks and are not associated with complications in the vast majority of infants, though rare links to syndromes like Beckwith-Wiedemann may occur if located on the lower back alongside other features.^[58] Variants of salmon patches are distinguished primarily by location: "angel's kiss" refers to those on the forehead, glabella, or eyelids, which tend to resolve more readily, while "stork bite" specifically denotes nape or posterior scalp lesions that are more likely to endure.^[9]^[59] These terms are colloquial and used interchangeably with nevus simplex in medical contexts.^[60]

Infantile Hemangiomas (Strawberry Marks)

Infantile hemangiomas, also known as strawberry marks, are the most common benign vascular tumors of infancy, arising from the proliferation of endothelial cells that line blood vessels. These lesions typically appear shortly after birth as small red macules or telangiectasias and develop into raised, bright red, rubbery nodules or plaques that resemble the surface of a strawberry, particularly in superficial forms located in the upper dermis. They can be classified as superficial, deep, or mixed based on their depth and involvement; superficial hemangiomas present as vivid red and warm to the touch, deep ones appear as bluish subcutaneous masses with a less defined surface hue, and mixed types combine features of both. Although most are solitary, multiple lesions occur in up to 30% of cases, and they predominantly affect females and premature infants. The natural history of infantile hemangiomas is characterized by distinct phases of growth and regression. The proliferative phase begins within the first few weeks of life and involves rapid expansion, peaking between 3 and 6 months of age, with most growth completing by 9 to 12 months; during this period, the tumor can increase in size up to 30 times its initial volume due to ongoing endothelial cell hyperplasia and vascular channel formation. This is followed by a plateau phase around 12 months, transitioning into the involution phase, where the lesion gradually flattens, softens, and fades as endothelial cells undergo apoptosis and fibrofatty tissue replaces the vascular components; approximately 50% of hemangiomas fully involute by age 5 years, 70% by age 7 years, and nearly all by age 10 years, though residual telangiectasias or atrophic skin changes may persist in some cases. Complications arise in about 10-15% of infantile hemangiomas, with ulceration being the most frequent, often occurring during the proliferative phase due to tension on the overlying skin and leading to pain, bleeding, secondary infection, and scarring. Functional impairments, such as airway obstruction from subglottic or laryngeal involvement, can be life-threatening and are more common in lesions located in the beard distribution area of the face or neck. Segmental facial hemangiomas, which cover a dermatomal distribution and exceed 5 cm in diameter, carry a heightened risk of association with PHACE syndrome—a neurocutaneous disorder involving posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, and eye abnormalities—necessitating multidisciplinary evaluation for underlying structural issues. Recent advancements in management, particularly with beta-blockers like propranolol, have transformed outcomes for complicated cases, achieving response rates exceeding 90% in halting proliferation and promoting involution when initiated early in the proliferative phase.

Port-Wine Stains

Port-wine stains, also known as nevus flammeus, are congenital capillary malformations characterized by pink to purple, flat patches on the skin resulting from malformed and dilated capillaries in the superficial dermal plexus.^[62] These lesions are typically present at birth and appear as well-demarcated, irregular patches that blanch slightly under pressure, often following the distribution of sensory nerves such as the trigeminal nerve branches.^[63] Port-wine stains are lifelong vascular anomalies with a prevalence of approximately 0.3% to 0.5% in newborns, affecting individuals regardless of sex or ethnicity.^[11] When located on the face in the V1 (ophthalmic) distribution of the trigeminal nerve, particularly involving the forehead and upper eyelid, they raise suspicion for associated Sturge-Weber syndrome, with about 15% to 20% of such cases linked to this neurocutaneous disorder.^[63] In Sturge-Weber syndrome, affected individuals face an elevated risk of complications, including approximately 30% developing glaucoma due to ocular vascular involvement and seizures arising from leptomeningeal angiomatosis, often manifesting in infancy.^[62] Histologically, port-wine stains feature ectatic, thin-walled capillaries and post-capillary venules scattered throughout the upper and mid-dermis, with a notable absence of smooth muscle support around the vessels, leading to progressive dilatation over time.^[64] These malformed vessels arise from somatic mutations in the GNAQ gene, disrupting normal vascular development and innervation.^[11] As individuals age, port-wine stains often progress, darkening from pink to deep purple and developing nodular hypertrophy or cobblestoning in adulthood due to ongoing ectasia and perivascular fibrosis.^[65] This evolution can have significant psychological impacts, including reduced quality of life, social stigma, anxiety, and depression, particularly when lesions are prominent on the face.^[66]

Diagnosis

Clinical Assessment

Clinical assessment of birthmarks begins with a detailed history taking to understand the lesion's characteristics and potential implications. Healthcare providers inquire about the onset, noting that vascular malformations like port-wine stains are typically present at birth, while infantile hemangiomas often appear within the first few weeks to months of life.^[67] Family history is explored to identify hereditary conditions, such as Osler-Weber-Rendu syndrome associated with vascular lesions.^[68] Associated symptoms, including pain, rapid growth, ulceration, or functional impairments like visual obstruction, are documented to guide further evaluation.^[60] The physical examination involves a systematic inspection and palpation of the birthmark and surrounding skin. Providers assess the location, size, color, shape, and texture, distinguishing flat pigmented lesions like café au lait spots from raised vascular ones like hemangiomas, which may appear bright red or bluish.^[67] Palpation evaluates compressibility and warmth; vascular malformations often feel soft and can be emptied of blood with pressure, while proliferating hemangiomas are firm and warm due to increased blood flow.^[67] A Wood's lamp, emitting ultraviolet light, is used to determine pigment depth in lesions like café au lait spots, which appear light brown with enhanced contrast, or nevus of Ota, showing intensified blue-black pigmentation, aiding in differentiation from epidermal lesions.^[69] Red flags during assessment prompt urgent referral, including rapid growth, ulceration, irregular borders, asymmetry, or changes in color and size, which may indicate complications or malignancy risk.^[70] Syndromic features, such as multiple café au lait spots (more than five suggesting neurofibromatosis) or port-wine stains involving the ophthalmic (V1) division of the trigeminal nerve (with an estimated risk of approximately 15-25% for Sturge-Weber syndrome with glaucoma or seizures), require immediate specialist evaluation.^[71] Lesions in critical areas, like the eyelid, spine base, or airway, signal potential neurological or ophthalmological involvement.^[70] In pediatric patients, assessment emphasizes growth monitoring, as hemangiomas proliferate rapidly in the first 6-12 months before involuting, necessitating serial examinations to track changes and detect complications like high-output cardiac failure in diffuse cases.^[68] Adult assessments focus more on stability, with changes in longstanding lesions raising concerns for secondary issues, though most birthmarks remain benign without progression.^[60]

Diagnostic Tests and Imaging

Diagnostic tests and imaging for birthmarks are typically employed when clinical assessment raises concerns about atypical features, potential malignancy, or associated syndromes, rather than for routine evaluation of benign lesions. Biopsy is rarely required for straightforward birthmarks but may be indicated for suspicious pigmented lesions, such as congenital melanocytic nevi that exhibit irregular borders, color variation, or rapid growth, to exclude melanoma or other pathologies. A punch biopsy, involving a small circular tool to extract a core sample of skin, is the preferred method; histopathological examination can reveal nests of melanocytes in nevi or vascular ectasia in malformations, confirming the diagnosis without extensive tissue removal.^[1]^[72] Imaging modalities play a key role in assessing vascular birthmarks, particularly to evaluate depth, blood flow, and involvement of underlying structures. Ultrasound with Doppler is a first-line, non-invasive tool for infantile hemangiomas and other vascular lesions, allowing visualization of vascular flow patterns, lesion depth, and soft tissue involvement to differentiate high-flow from low-flow anomalies. For deeper lesions or suspected syndromic associations, magnetic resonance imaging (MRI) is utilized, especially in port-wine stains linked to Sturge-Weber syndrome, where it detects leptomeningeal angiomas or brain parenchymal abnormalities that may require neurological intervention.^[73]^[72]^[74] Genetic testing is reserved for high-risk cases suggestive of underlying syndromes, such as multiple café au lait spots prompting evaluation for neurofibromatosis type 1 (NF1). A targeted NF1 gene panel, analyzing mutations in the NF1 gene on chromosome 17, confirms the diagnosis when clinical criteria like six or more spots are met, guiding family counseling and surveillance for complications. Recent advances as of 2025 include non-invasive optical coherence tomography (OCT), particularly OCT angiography (OCTA), which provides high-resolution, depth-resolved imaging of vascular networks in birthmarks like port-wine stains, enabling precise assessment of vessel depth and density without radiation or contrast agents.^[75]^[76]

Management and Treatment

Observation and Monitoring

Observation and monitoring are recommended for most benign birthmarks that do not pose immediate risks, such as small congenital melanocytic nevi (moles under 1.5 cm in diameter) and salmon patches (nevus simplex). Salmon patches typically resolve spontaneously without intervention by 18 months in the majority of cases.^[9] Small congenital melanocytic nevi do not resolve spontaneously but require ongoing monitoring for changes.^[9] For these types, routine clinical follow-up focuses on tracking natural involution where applicable, with periodic examinations to assess size and appearance, enabling early detection of any atypical changes.^[77] Standard protocols for monitoring include the ABCDE rule for congenital moles, assessing for asymmetry, irregular borders, color variation, diameter greater than 6 mm, and evolving features to identify potential malignancy risks.^[78] For facial port-wine stains, particularly those involving the eyelid or forehead, regular ophthalmology evaluations are essential to screen for glaucoma or other ocular complications associated with Sturge-Weber syndrome.^[79] These checks typically involve measuring intraocular pressure and may include imaging if structural abnormalities are suspected, with monitoring frequency tailored to the lesion's location and extent.^[79] Parents should be educated on key signs of change warranting medical attention, such as sudden bleeding, rapid enlargement, or shifts in color and texture, to facilitate prompt evaluation.^[80] Reassurance is provided regarding the benign nature of many birthmarks, emphasizing that conditions like salmon patches and superficial infantile hemangiomas often fade significantly by age 4-5 years without scarring.^[81] This education helps alleviate anxiety while promoting vigilant home observation through periodic self-checks. Long-term management emphasizes lifelong sun protection to prevent darkening or hypertrophy of birthmarks, with recommendations for broad-spectrum sunscreen (SPF 30 or higher) and protective clothing, especially over vascular lesions like port-wine stains.^[82] Zinc oxide-based formulations are particularly suitable for vascular birthmarks to minimize irritation and provide effective UV blocking.^[82]

Interventional Therapies

Interventional therapies for birthmarks primarily target symptomatic or cosmetically concerning lesions, such as infantile hemangiomas and port-wine stains, when observation alone is insufficient. For infantile hemangiomas, oral propranolol serves as the first-line medical treatment, administered at a dosage of 2-3 mg/kg/day divided into three doses for 6-12 months, achieving complete or nearly complete clearance in up to 95% of cases with response rates of 88-95% in reducing lesion size and proliferation.^[83] This beta-blocker works by inducing vasoconstriction, apoptosis of endothelial cells, and inhibition of angiogenesis, with monitoring for side effects like bradycardia or hypoglycemia essential in infants.^[83] For smaller, superficial hemangiomas, topical timolol maleate 0.5% gel or solution applied twice daily offers a non-invasive alternative, demonstrating efficacy in 70-80% of cases with minimal systemic absorption and no significant adverse effects.^[84]^[85] Laser therapy is a cornerstone for vascular birthmarks like port-wine stains, with the 595-nm pulsed dye laser (PDL) being the standard, targeting oxyhemoglobin to achieve vessel coagulation. Treatment typically requires multiple sessions (6-12 or more) spaced 4-6 weeks apart, resulting in good-to-excellent fading in 60-70% of patients, particularly when initiated early in childhood.^[86]^[87] By 2025, advancements in picosecond-domain lasers have improved clearance rates for resistant port-wine stains, offering shorter pulse durations for enhanced precision and reduced thermal damage, with reported fading improvements of up to 80% in select cohorts when combined with dynamic cooling.^[88]^[89] Surgical interventions are reserved for large or complicated birthmarks. Excision is indicated for giant congenital melanocytic nevi or persistent, ulcerated hemangiomas, often performed in stages using tissue expansion or serial excision to minimize scarring and reconstruct defects, with high satisfaction rates in pediatric cases.^[90]^[91] Sclerotherapy, involving percutaneous injection of sclerosants like ethanol or bleomycin, effectively treats venous malformations associated with birthmarks by inducing fibrosis and reducing lesion volume, achieving symptomatic relief in 70-90% of patients with low complication rates when guided by imaging.^[92]^[93] Emerging therapies in 2025 focus on molecular targets for complex vascular anomalies. Oral sirolimus, an mTOR inhibitor, has shown efficacy in reducing volume and improving symptoms in venous and lymphatic malformations unresponsive to conventional treatments, with systematic reviews reporting response rates of 80-85% and a favorable safety profile at doses of 1-2 mg/m²/day.^[94]^[95] Genetic-targeted approaches, informed by mutations in genes like PIK3CA or GNAQ, include PI3K inhibitors such as alpelisib for overgrowth syndromes linked to vascular birthmarks, offering personalized treatment with up to 60% reduction in lesion progression in mutated cases.^[96]^[97]

Associated Conditions and Complications

Linked Syndromes

Certain birthmarks serve as clinical markers for underlying genetic syndromes, prompting targeted diagnostic evaluation to identify associated multisystem involvement. Neurofibromatosis type 1 (NF1) is characterized by the presence of more than six café au lait spots, typically greater than 5 mm in diameter in children or 15 mm in adults, along with axillary or inguinal freckling and Lisch nodules, which are iris hamartomas visible on slit-lamp examination.^[98]^[99]^[100] Sturge-Weber syndrome manifests with a facial port-wine stain in the distribution of the ophthalmic or maxillary branch of the trigeminal nerve, often accompanied by leptomeningeal angiomas detectable on neuroimaging, which can lead to neurological complications such as seizures and ocular issues including glaucoma.^[62]^[101]^[102] PHACES syndrome is identified by a large segmental infantile hemangioma, usually on the face or neck exceeding 5 cm, associated with structural anomalies such as posterior fossa malformations, arterial cerebrovascular issues, cardiac defects like coarctation of the aorta, eye abnormalities, and sternal clefting.^[103]^[104] Other linked syndromes include Klippel-Trenaunay syndrome, featuring limb-localized vascular malformations such as port-wine stains and venous varicosities alongside soft tissue and bony overgrowth, and neurocutaneous melanosis, which involves giant congenital melanocytic nevi covering more than 1.5-2% of body surface area with meningeal melanocytic proliferation.^[105]^[106]^[107]^[108] For infants with high-risk birthmarks, such as extensive facial port-wine stains or large segmental hemangiomas, screening typically includes gadolinium-enhanced MRI of the brain and spine to assess for leptomeningeal or vascular involvement, echocardiography for cardiac anomalies in PHACES, and genetic testing for confirmation in NF1 or other suspected syndromes.^[109]^[110]^[98]^[111]

Potential Health Risks

Pigmented birthmarks, such as congenital melanocytic nevi, carry a small risk of malignant transformation into melanoma, particularly in larger lesions, though this occurs in less than 1% of small nevi under 1 cm in diameter.^[112] Additionally, these birthmarks can lead to cosmetic concerns and psychological distress, including feelings of self-consciousness and social withdrawal due to their visible nature.^[1] Vascular birthmarks present more immediate physical risks; for instance, infantile hemangiomas are prone to ulceration and bleeding, affecting 10-15% of cases, often in areas of friction like the diaper region or lips.^[113] Port-wine stains may develop soft tissue hypertrophy over time, leading to thickening and potential scarring that alters facial contours.^[114] Functional impairments can also arise, such as vision obstruction or astigmatic amblyopia from periocular hemangiomas that cause eyelid swelling or ptosis.^[115] Ulcerated birthmarks heighten the risk of secondary bacterial infections, which can delay healing and result in further complications like scarring if not managed promptly.^[116] Sun exposure exacerbates risks for pigmented birthmarks by increasing UV absorption in darker areas, potentially accelerating cellular changes that elevate malignancy potential.^[117] Beyond physical concerns, birthmarks often impact quality of life, with affected individuals facing bullying, reduced self-esteem, and heightened emotional distress from societal stigma.^[118] Recent studies indicate that persistent visible birthmarks are associated with higher rates of anxiety compared to unaffected peers, underscoring the need for supportive interventions.^[66]

Historical and Cultural Aspects

Historical Explanations and Myths

In ancient Greek medicine, birthmarks were often attributed to physical pressures or displacements of the womb during pregnancy, as described by Hippocrates and his followers, who viewed the uterus as a mobile organ capable of influencing fetal development and causing skin discolorations or blemishes.^[119] This perspective reflected broader Greco-Roman beliefs in bodily divination, where moles or birthmarks served as omens or indicators of future events, detailed in texts like the pseudo-Aristotelian works on physiognomy. During the medieval period in Europe, birthmarks were frequently interpreted as supernatural signs or omens, sometimes linked to divine judgment or demonic influence; for example, irregular skin marks were considered "witch marks" or devil's brands, used as evidence in witch trials to accuse individuals of pacts with the devil.^[120] The maternal impression theory gained prominence in the 18th and 19th centuries, positing that a pregnant woman's vivid emotions, frights, or unfulfilled cravings could imprint corresponding marks on the fetus through the power of her imagination acting on the womb.^[121] For instance, a red "strawberry" birthmark was thought to arise from the mother's unsatisfied longing for berries, while a fright involving an animal might produce a similarly shaped mark, as documented in medical and folk literature of the era.^[122] This doctrine, rooted in earlier folklore but formalized in scientific discourse, persisted despite growing skepticism from empirical observations.^[123] These historical explanations and myths largely declined after the mid-20th century with advances in dermatology and genetics, which identified birthmarks as vascular malformations or pigmentary disorders arising from developmental or hereditary factors rather than maternal influences or omens.^[124] This shift contrasted sharply with prior beliefs by emphasizing biological mechanisms over psychological or supernatural ones.

Cultural Significance

Birthmarks have held diverse symbolic meanings in folklore across cultures, often interpreted as signs of good fortune or divine intervention. In Mongolian and broader Asian traditions, the Mongolian spot—a bluish-gray birthmark commonly appearing on the lower back or buttocks of infants—is regarded as a "heavenly seal" bestowed by the eternal blue sky, symbolizing protection and a blessing from higher powers.^[125] This mark is seen as a spiritual stamp from ancestors or deities, ensuring the child's safety and linking them to nomadic heritage, with variations in Korean folklore attributing it to the goddess Samshin Halmoni slapping the baby to hasten birth and affirm vitality.^[126] Similarly, in European tales, stork bites (salmon patches on the neck or eyelids) are known as "angel's kisses," derived from myths where storks deliver babies or angels mark them with affection, portraying the birthmark as an omen of purity and divine favor.^[127]^[128] Prominent individuals have elevated birthmarks to icons of beauty and identity in popular culture. Supermodel Cindy Crawford's facial mole, often celebrated as her signature beauty mark, transformed initial childhood insecurities—where her sisters called it an "ugly mark"—into a defining feature that became synonymous with allure and confidence in the fashion industry during the 1980s and 1990s.^[129]^[130] In modern society, birthmarks appear in media through creative expressions like tattoos that incorporate or mimic them, turning perceived flaws into artistic statements of empowerment and self-acceptance.^[131] Advocacy organizations play a key role in reducing stigma, with groups such as the Vascular Birthmarks Foundation providing support networks, awareness campaigns, and resources to normalize vascular birthmarks and foster community among affected individuals.^[132] Similarly, Caring Matters Now focuses on congenital melanocytic nevi, educating the public to combat negative perceptions and promote positive self-image.^[133] Globally, birthmarks feature in Indigenous art as symbols of heritage and identity, as seen in Australian Aboriginal painter Fiona Omeenyo's works titled Birthmarks, which blend traditional motifs with personal narratives of cultural connection.^[134] South African artist Sthenjwa Luthuli's 2025 exhibition Umkhangu (Birthmark) at the Norval Foundation explores these marks as visual storytelling, bridging personal and communal histories through fourteen paintings created over 15 years.^[135] Reflecting 2025 trends in body positivity, campaigns like the Vascular Birthmarks Foundation's Indigenous Peoples' Day awareness initiative encourage "birthmark bedazzling" activities, where children adorn their marks with glitter and color to celebrate uniqueness and challenge societal norms.^[136]

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Oct 13, 2023 · 71% of patients achieved excellent clearance and 29% patients achieved good-moderate clearance of their angioma. Patients were asked for a ...
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Erase the Red: How Laser Pico Targets Port-Wine Stains - Rheinlaser
Jan 22, 2025 · Laser Pico effectively targets port-wine stains with ultra-precise pulses, offering a safe, efficient solution for reducing discoloration.
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Early Intervention for Port-Wine Stains - Dermatology Times
Mar 9, 2025 · Advances in laser technology, such as larger spot sizes and improved cooling, enhance treatment safety and efficacy for young patients.
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Surgical management of large facial congenital melanocytic nevi ...
Aug 12, 2025 · The Ahmed technique offers a promising and practical approach for the excision of large congenital facial nevi in children. This technique ...
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Safety and effectiveness of surgical excision of medium, large ... - jpras
Nov 17, 2022 · To assess the outcomes of surgical excision of medium-to-giant CMN. Primary outcome: safety (complications). Secondary outcome: effectiveness (satisfaction and ...
[93]
Sclerotherapy after embolization of draining vein: A safe treatment ...
Conclusion. Percutaneous sclerotherapy of venous malformations using absolute ethanol and bleomycin A5 is safe and effective.Clinical Research Study · Material And Methods · Discussion
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Treatment of Venous Malformations With Sclerosant in Microfoam ...
Sclerotherapy is an alternative method of treatment for venous malformations, and is used to reduce the size of the lesion, preoperatively as a support to ...
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Sirolimus for Venous Malformations: A Systematic Review of Efficacy ...
Sep 10, 2025 · This systematic review evaluates the efficacy and safety of sirolimus in the management of venous malformations.
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Effectiveness and safety of sirolimus in the treatment of venous ...
The findings indicate that sirolimus significantly reduces the volume of vascular malformations, enhances hemoglobin levels, and improves coagulation function, ...
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https://www.ncbi.nlm.nih.gov/books/NBK1109/
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Neurofibromatosis 1 - GeneReviews® - NCBI Bookshelf - NIH
Apr 3, 2025 · Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by multiple café au lait macules, intertriginous freckling, multiple cutaneous neurofibromas,
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Sep 10, 2024 · Visible signs of NF1 can include widespread cafe au lait spots, many neurofibromas in the facial area or large neurofibromas. In some people ...
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Neurofibromatosis Type 1 - StatPearls - NCBI Bookshelf - NIH
Freckles are small and grouped when compared to cafe-au-lait macules. It is present in around 70% of individuals and appears later than café-au-lait spots by 3 ...
[102]
Sturge-Weber Syndrome: A Review of Pathophysiology, Genetics ...
Apr 24, 2023 · Sturge-Weber syndrome (SWS) is a congenital, sporadic, and rare neurocutaneous disorder, characterized by the presence of a facial port-wine birthmark (PWB), ...
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Sturge-Weber syndrome - Genetics - MedlinePlus
Oct 1, 2018 · Sturge-Weber syndrome is a condition that affects the development of certain blood vessels, causing abnormalities in the brain, skin, and eyes from birth.
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PHACE Syndrome - StatPearls - NCBI Bookshelf - NIH
PHACE syndrome should be suspected in the presence of cervicofacial infantile hemangioma over 5cm in size, and a systemic evaluation is required. Thus, history ...Missing: obstruction | Show results with:obstruction
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PHACE syndrome: clinical manifestations, diagnostic criteria, and ...
PHACE syndrome was first defined as the association of large and segmental infantile hemangioma, usually on the face, head, or cervical region, with ...
[106]
Klippel-Trenaunay syndrome - Symptoms and causes - Mayo Clinic
Feb 12, 2022 · Main signs of this congenital disorder involve a red birthmark (port-wine stain), vein malformations, and overgrowth of tissues and bones.
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Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis
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Neurocutaneous Melanosis in Association With Large Congenital ...
Feb 7, 2019 · Neurocutaneous melanosis (NCM) is a rare disorder, represents pigment cell tumors of the leptomeninges, and occurs in association with large or multiple CMN.Missing: moles | Show results with:moles
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Screening for Sturge-Weber syndrome: A state-of-the-art review
Oct 16, 2017 · Infants with a high-risk distribution of port-wine stains are commonly screened for Sturge-Weber syndrome using brain magnetic resonance imaging ...
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PHACE Syndrome: Consensus-Derived Diagnosis and Care ...
PHACE syndrome (posterior fossa anomalies, hemangioma, arterial lesions, cardiac abnormalities/coarctation of the aorta, eye anomalies) is characterized by ...
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Neurological signs, symptoms and MRI abnormalities in patients ...
Mar 2, 2022 · A congenital melanocytic naevus (CMN) is a rare skin condition that can be associated with abnormalities of the central nervous system (CNS).
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Congenital Nevi - BC Cancer
Congenital nevi less than 1 cm diameter appear to have a melanoma risk of less than 1%, whereas nevi of twice the size of the palm probably have a lifetime ...
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Port-wine stains may be accompanied by soft tissue hypertrophy, particularly when the extremities are affected. It is important to recognize the combination of ...
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Jun 23, 2023 · An infantile hemangioma is a birthmark that is made up of a dense group of blood vessels. It often appears on the surface of the skin as a spongy mass.Overview · Symptoms · Causes
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Birthmarks - American Society for Dermatologic Surgery
Allow excessive sun exposure. The darker pigmentation absorbs more sunlight, making birthmarks more susceptible to becoming cancerous. Why treat birthmarks?
[119]
Paediatric vascular birthmarks--the psychological impact ... - PubMed
Vascular birthmarks are common. Treatment strategies are improving, but there is a need to adequately address the psychosocial impact that these lesions ...
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Vascular Birthmarks in Folklore, History, Art, and Literature
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Moles, birthmarks and red hair: the anatomical features used to ...
Oct 31, 2024 · The belief was that the devil branded witches' bodies with symbolic, material marks – such as unusual growths or blemishes.Missing: medieval | Show results with:medieval
[122]
From Maternal Impressions to Eugenics: Pregnancy and Inheritance ...
Oct 24, 2020 · This essay examines the theory of maternal impressions, the belief that a woman's experiences or emotions during pregnancy could explain congenital disability.
[123]
Birthmark and blemish: The doctrine of maternal imagination
Abstract. The assumption that conceiving or pregnant women may harm their fetus by uncontrolled imagination originated in many cultures.
[124]
Mapping the field's past (Section 1) - The Handbook of DOHaD and ...
Jun 20, 2024 · Maternal impression is the enduring notion that the emotions and experiences of a pregnant woman could leave permanent marks on her unborn child ...
[125]
(PDF) Hawthorne's Ego Defense Mechanism on “The Birthmark”
Aug 7, 2025 · Nathaniel Hawthorne's "The Birthmark" is a rich embroidery of human psychology entwined to Puritan society. The following analysis examines ...
[126]
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The present paper summarizes the main features of 50 published cases in which an unusual stimulus to a pregnant woman was followed by the birth of a baby with ...
[127]
History of dermatology: the study of skin diseases over the centuries
In the 1950s and 1960s, dermatologists learned surgical procedures, developed techniques, publications, and technological resources that definitively ...
[128]
Mysteries of the Mongolian blue spot - Mongolianz
Jan 23, 2019 · The Mongolian spot is a benign, flat, irregular birthmark, often blue, that appears on the back of every Mongolian baby. It is caused by ...
[129]
My Mongolian Spot - The American Scholar
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Angel Kiss Birthmark Spiritual Meaning and Symbolism
Aug 16, 2025 · In European folklore, angel kiss birthmarks are often seen as signs of divine blessing and spiritual purpose. Some medieval European traditions ...
[132]
The History Of Cindy Crawfords Beauty Mark - Refinery29
Feb 20, 2015 · We prefer to refer to a small, brown, raised spot on the face as a beauty mark. Whether it sits above the eyebrow, off-center on the chin, on ...
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Cindy Crawford Says She Once 'Hated' Having a Beauty Mark
Apr 7, 2020 · The mom of two reveals she “used to hate” her beauty mark (before Campbell admits she's always wanted one!).
[134]
The Artistic Evolution of Tattoos and Birthmarks - theskinartistry
Rating 4.9 (92) Sep 20, 2023 · Some individuals choose to incorporate their birthmarks into their tattoo designs, transforming an imperfection into an exquisite work of art.
[135]
Vascular Birthmarks Foundation – Vascular Birthmarks Information ...
Support Groups · Vascular Birthmarks Legislative Initiative · Parent Advocacy Network · VBF Adults Living With… Advocacy Network · Raise Awareness · VBF Day of ...
[136]
Caring Matters Now (CMN) The Congenital Melanocytic Naevus ...
Caring Matters Now aims to raise awareness of CMN to 1) reduce the stigma and negative perceptions attached to living with CMN and 2) educate the medical ...
[137]
Fiona Omeenyo Art - Aboriginal Paintings from Lockhart River
Fiona Omeenyo: Celebrated Aboriginal Artist from Lockhart River. Australian Aboriginal Art. Award Winning Artist. Titled : Birthmarks. Size : 96 cm x 70 cm.
[138]
Sthenjwa Luthuli and Norval Foundation Present 'Umkhangu ...
The title Umkhangu, derived from the hero artwork of the exhibition, is translated from isiZulu as “birthmark.” It refers not only to a physical mark one is ...
[139]
Celebrate Indigenous Peoples Day with Birthmark Awareness
Oct 12, 2025 · Birthmark Bedazzling, hosted by VBF Global Ambassador Paige Billiot, is a fun way for kids to showcase their birthmark art—using color, glitter, ...