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Chemical composition

Chemical composition refers to the identity, relative proportions, and spatial arrangement of atoms or elements within a chemical substance, defining its molecular or structural makeup.^[1] This concept forms the cornerstone of chemistry, enabling scientists to predict and explain the physical and chemical properties of substances, as well as their behavior in reactions.^[2] For instance, the specific ratios of elements in a compound can lead to vastly different characteristics compared to its constituent elements alone, such as how sodium and chlorine combine to form table salt with properties neither element exhibits independently.^[3] Determining chemical composition is essential for quantitative analysis in research and industry, achieved through techniques ranging from traditional gravimetric methods like combustion analysis to advanced instrumental approaches such as X-ray fluorescence (XRF), energy-dispersive spectroscopy (EDS), and chromatography.^[4]^[5] These methods ensure precise measurement of elemental or molecular content, supporting applications in fields like materials science for alloy development, environmental monitoring for pollutant identification, and pharmaceuticals for ensuring drug purity and efficacy.^[6]

Fundamentals

Definition

Chemical composition refers to the identity and relative proportions of the chemical species—such as atoms, ions, or molecules—that constitute a given substance or material.^[1] This concept encompasses the specific types of elements or compounds present and their arrangement, which fundamentally determines the physical and chemical properties of the substance.^[1] At its core, understanding chemical composition requires familiarity with basic building blocks of matter: atoms are the smallest indivisible units of an element that retain its chemical properties, while molecules consist of two or more atoms bonded together, forming stable entities that can represent either elements (like diatomic oxygen) or compounds (like water).^[7] Ions, charged particles resulting from atom gain or loss of electrons, also play a role in compositions involving electrolytes or ionic compounds.^[8] Chemical composition is distinguished by qualitative and quantitative aspects: qualitative analysis identifies the types of elements or compounds present in a sample, such as detecting carbon and hydrogen in an organic material, whereas quantitative analysis determines their relative proportions, often expressed by mass, mole fraction, or volume.^[9] These dimensions together provide a complete characterization, enabling predictions about reactivity and behavior. The concept of chemical composition originated with John Dalton's atomic theory, published in 1808, which posited that all matter consists of indivisible atoms combining in simple whole-number ratios to form compounds, laying the groundwork for understanding proportional makeup.^[10] This idea evolved significantly with Dmitri Mendeleev's development of the periodic table in 1869, which organized elements by increasing atomic weight and revealed periodic patterns in properties, facilitating the systematic description of elemental contributions to compositions.^[11]

Representation

The chemical composition of compounds is commonly represented using empirical and molecular formulas, which denote the relative and absolute numbers of atoms of each element present. The empirical formula expresses the simplest whole-number ratio of atoms in a compound, without specifying the actual number of atoms in a molecule. For instance, the empirical formula for glucose is CH₂O, indicating a 1:2:1 ratio of carbon, hydrogen, and oxygen atoms.^[12] The molecular formula, in contrast, provides the exact number of atoms of each element in a single molecule of the compound. It can be derived from the empirical formula by multiplying the subscripts by a scaling factor determined from the ratio of the molecular mass to the empirical formula mass. For glucose, the molecular formula is C₆H₁₂O₆, which is obtained by multiplying the empirical formula CH₂O by 6, as the molecular mass (180 g/mol) divided by the empirical formula mass (30 g/mol) yields this integer multiplier.^[13]^[14] For quantifying composition in both pure compounds and mixtures, percentage composition by mass is a standard metric, calculated as the mass of a specific element divided by the total molar mass of the substance, multiplied by 100. This approach allows comparison of elemental contributions regardless of sample size. In water (H₂O), for example, hydrogen constitutes 11.19% by mass ((2 × 1.008 g/mol) / 18.016 g/mol × 100), while oxygen accounts for 88.81% ((1 × 16.00 g/mol) / 18.016 g/mol × 100).^[15] In mixtures, molar composition is often described using the mole fraction (χ_i), defined as the number of moles of a component (n_i) divided by the total number of moles in the mixture (n_total), such that the sum of all mole fractions equals 1. This dimensionless quantity is particularly useful for solutions and gas mixtures, as it reflects the relative proportions on a molecular scale.^[16] For gaseous mixtures at constant temperature and pressure, volumetric composition—expressed as volume percentages—equates to mole fractions due to Avogadro's law, which states that equal volumes of different gases contain the same number of molecules under identical conditions. This principle enables direct correlation between measured gas volumes and their molar contributions in analyses such as atmospheric composition.^[17]^[18]

Pure Substances

Elements

Elements are pure chemical substances composed solely of atoms with the same number of protons in their nuclei, making them the simplest form of matter that cannot be chemically decomposed into simpler substances.^[19]^[20] The atomic number, denoted as Z, uniquely defines each element by specifying this proton count; for instance, carbon has Z = 6, meaning all carbon atoms possess exactly six protons.^[21] Despite this uniformity in proton number, elements often exhibit isotopic variations, where atoms differ in neutron count but retain the same Z value, influencing the element's average atomic mass. In natural samples, isotopes occur in specific abundance ratios; for carbon, the stable isotopes are carbon-12 (with six neutrons, comprising 98.93% abundance) and carbon-13 (with seven neutrons, at 1.07% abundance).^[22] These proportions result in carbon's standard atomic weight of approximately 12.011, reflecting the weighted average rather than a single isotope's mass. Elements can also manifest in different structural forms known as allotropes, which arise from variations in atomic bonding arrangements while maintaining identical elemental composition. For example, diamond and graphite are both pure carbon (Z = 6), yet diamond features a tetrahedral network of sp³-hybridized bonds yielding exceptional hardness, whereas graphite consists of layered sp²-hybridized sheets enabling lubricity and electrical conductivity.^[23] Such allotropes underscore that an element's chemical composition remains unchanged across these forms, with properties determined by atomic organization rather than composition itself.

Compounds

A chemical compound is a pure substance composed of two or more different elements chemically bonded together in a fixed proportion by mass. This fixed composition ensures that the ratio of elements remains constant regardless of the compound's origin or preparation method. For instance, sodium chloride (NaCl) consists of sodium and chlorine atoms in a 1:1 atomic ratio, resulting in approximately 39.3% sodium and 60.7% chlorine by mass.^[24] The law of definite proportions, formulated by Joseph Proust in 1794, underpins this characteristic of compounds, stating that every chemical compound contains its constituent elements in the same fixed ratio by mass. Proust demonstrated this through experiments on substances like copper carbonate and iron oxides, showing consistent elemental ratios across samples prepared differently.^[25] These stoichiometric ratios define the compound's identity and properties, distinguishing it from elements or mixtures.^[25] Compounds are classified based on bonding type, which influences their compositional description. Ionic compounds, such as sodium chloride (Na⁺Cl⁻), consist of positively and negatively charged ions attracted by electrostatic forces, with the overall composition achieving electrical neutrality through balanced ion ratios.^[24] Covalent compounds, like water (H₂O), feature atoms linked by shared electron pairs, where the composition reflects the number of shared electrons needed to achieve stable electron configurations for each atom.^[26] Certain compounds incorporate solvent molecules into their structure, forming hydrates or solvates that alter the overall composition. Hydrates include water molecules in fixed ratios within the crystal lattice, as seen in copper(II) sulfate pentahydrate (CuSO₄·5H₂O), where five water molecules accompany each formula unit of the anhydrous salt.^[27] Solvates generalize this to other solvents, maintaining the definite proportions characteristic of compounds.^[28]

Mixtures and Composites

Homogeneous Mixtures

Homogeneous mixtures, also known as solutions, are combinations of two or more substances that exhibit a uniform composition and appearance throughout the sample, with components indistinguishable at the macroscopic level.^[29] In such mixtures, the solute is evenly distributed within the solvent, resulting in a single phase that behaves as a consistent substance. A classic example is a saltwater solution, where sodium chloride (NaCl) is fully dissolved in water, yielding a clear, uniform liquid regardless of the sample location.^[30] The chemical composition of homogeneous mixtures is primarily characterized by the concentration of the solute in the solvent, which quantifies the relative amounts of each component. Molarity (M) is defined as the number of moles of solute per liter of solution, providing a volume-based measure useful in laboratory settings.^[31] Molality (m), in contrast, expresses concentration as the moles of solute per kilogram of solvent, offering a temperature-independent metric that accounts for solute-solvent interactions without volume changes.^[32] These interactions, such as ion-dipole forces in aqueous solutions, ensure the solute particles are dispersed at the molecular level, maintaining homogeneity. Solute-solvent bonding influences solubility and stability, with composition ratios varying continuously unlike the fixed stoichiometry in compounds. Metallic homogeneous mixtures, or alloys, exemplify solid solutions where metals form uniform phases with adjustable compositions. Brass, for instance, is a copper-zinc alloy typically composed of 70% copper and 30% zinc by mass, though ratios can vary to tailor properties like ductility and corrosion resistance.^[33] In brass, zinc atoms substitute into the copper lattice, creating a substitutional solid solution that remains homogeneous across the material.^[34] The composition of homogeneous mixtures directly impacts colligative properties, which depend on the number of solute particles rather than their identity. Boiling point elevation, a key colligative effect, occurs when a non-volatile solute reduces the solvent's vapor pressure, requiring higher temperature for boiling. The magnitude is given by the formula:

\Delta T_b = K_b \cdot m \cdot i

where \Delta T_b is the boiling point increase, K_b is the solvent's molal boiling point elevation constant, m is the molality, and i is the van't Hoff factor accounting for solute dissociation (e.g., i = 2 for NaCl).^[35] This property underscores how composition governs macroscopic behavior in solutions, with applications in processes like antifreeze formulation.^[36]

Heterogeneous Mixtures

Heterogeneous mixtures are combinations of two or more substances where the composition varies from one region to another, resulting in non-uniform distribution of components.^[37] Unlike uniform mixtures, these systems exhibit distinct phases or regions that can often be visually or mechanically separated. A classic natural example is granite, an igneous rock composed of discrete phases such as quartz, feldspar, and mica, each with its own chemical makeup, leading to spatial variations in overall composition.^[38] Common types of heterogeneous mixtures include suspensions, colloids, and emulsions, each characterized by different particle sizes and behaviors. Suspensions consist of larger particles (typically greater than 1 μm) dispersed in a medium, such as sand in water, where the particles eventually settle due to gravity./11%3A_Solutions/11.07%3A_Colloidal_Suspensions) Colloids feature smaller particles (1–1000 nm) that remain suspended without settling, like milk where fat globules are dispersed in water.^[39] Emulsions are liquid-in-liquid dispersions, such as oil and vinegar in salad dressing, where one liquid forms droplets within another.^[40] The composition of these mixtures is typically described using phase volumes or weight fractions to quantify the proportions of each distinct phase.^[41] Engineered heterogeneous mixtures, known as composite materials, are designed for specific properties by combining distinct phases, such as in fiber-reinforced polymers (FRPs). In FRPs, a polymer resin serves as the continuous matrix phase, embedding high-strength fibers (e.g., carbon or glass) as the reinforcement phase, with compositions often specified by fiber volume fraction to optimize mechanical performance. These systems leverage the heterogeneity to achieve enhanced strength, stiffness, and durability beyond what either phase could provide alone. The Gibbs phase rule provides a fundamental framework for understanding the compositional variability in heterogeneous mixtures: F = C - P + 2, where F is the degrees of freedom (variables like temperature, pressure, or composition that can be independently changed while maintaining equilibrium), C is the number of independent components, and P is the number of phases.^[42] In a heterogeneous mixture with multiple phases, such as a two-phase system (P = 2) of two components (C = 2), the system has one degree of freedom (F = 1), meaning composition can vary along a univariant line in a phase diagram, reflecting the spatial non-uniformity.^[43] This rule highlights how phase interactions constrain the possible compositions in such systems.

Determination Methods

Experimental Techniques

Experimental techniques for determining chemical composition involve direct laboratory measurements that quantify the presence and amounts of elements, compounds, or mixtures in a sample. These methods rely on physical and chemical properties to isolate, separate, or detect analytes, providing empirical data essential for compositional analysis. Classical approaches, such as gravimetric and volumetric methods, form the foundation of quantitative analysis, while modern instrumental techniques like spectroscopy, chromatography, and X-ray methods offer enhanced sensitivity and specificity for complex samples.^[44] Gravimetric analysis determines the composition by precipitating the analyte as an insoluble compound, isolating it, and measuring its mass. For instance, sulfate ions in a sample can be precipitated as barium sulfate (BaSO₄), filtered, dried, and weighed to calculate the original concentration based on stoichiometry. This method is highly accurate for major components but requires careful control of precipitation conditions to ensure complete reaction and purity of the isolate.^[45] Volumetric titration, or titrimetry, quantifies composition through the volume of a standard solution (titrant) required to react completely with the analyte. In acid-base titrations, for example, the concentration of an acid is determined by titrating it with a base like sodium hydroxide, using an indicator such as phenolphthalein to detect the endpoint where the solution changes color. This technique is straightforward and precise for ionic species, relying on well-defined stoichiometry, though it demands accurate burette readings and stable endpoints.^[46] Spectroscopic methods exploit the interaction of electromagnetic radiation with matter to identify and quantify elements. Atomic absorption spectroscopy (AAS) measures the absorption of light by free atoms in the gas phase, particularly effective for metals like copper or lead, achieving detection limits around parts per billion (ppb) through flame or graphite furnace atomization. Inductively coupled plasma mass spectrometry (ICP-MS) enables multi-element analysis by ionizing samples in a high-temperature plasma and separating ions by mass-to-charge ratio, providing precise isotope ratios for elements such as strontium or uranium, with sensitivities down to parts per trillion. These techniques are indispensable for trace-level determinations in diverse matrices.^[47]^[48]^[49] Chromatographic techniques separate sample components based on differential interactions with a stationary and mobile phase, followed by detection and quantification. Gas chromatography (GC) is ideal for volatile compounds, such as hydrocarbons or pesticides, where the sample is vaporized and carried through a column by an inert gas, with separation achieved by boiling point and polarity differences; quantification occurs via peak area integration using detectors like flame ionization. High-performance liquid chromatography (HPLC) suits non-volatile organics, like pharmaceuticals or biomolecules, employing a liquid mobile phase under high pressure to resolve compounds on a packed column, often detected by UV absorbance for precise molar quantification. Both methods excel in mixture analysis by providing separation efficiency and reproducibility.^[50]^[51] X-ray techniques provide non-destructive elemental and structural insights into solid samples. Energy-dispersive X-ray spectroscopy (EDX), often coupled with scanning electron microscopy, generates characteristic X-rays from electron bombardment to map elemental distribution across a surface, identifying and quantifying elements from boron to uranium with spatial resolution down to micrometers. X-ray diffraction (XRD) analyzes crystal structure by measuring diffraction patterns from X-ray scattering off atomic planes, inferring composition through phase identification and lattice parameters, as in determining mineral phases in ores. These methods are particularly valuable for heterogeneous materials where spatial variation affects overall composition.^[52] Recent advancements as of 2025 include the integration of artificial intelligence (AI) and machine learning in data analysis for these techniques, particularly in spectroscopy and chromatography. AI algorithms automate peak identification, correct for interferences, and enable real-time processing of complex datasets, improving accuracy and throughput in applications like environmental monitoring and pharmaceutical quality control.^[53]^[54] The accuracy of these experimental techniques hinges on proper calibration with standards and mitigation of matrix effects, where sample components interfere with analyte signals, potentially leading to over- or underestimation. Calibration curves constructed from known concentrations ensure linearity, while matrix matching or standard addition methods correct for interferences, maintaining reliability across sample types.^[55]

Theoretical Approaches

Theoretical approaches to chemical composition involve computational methods that predict molecular structures, phase equilibria, and mixture behaviors without relying on direct experimental measurement, enabling efficient exploration of vast compositional spaces. These methods leverage fundamental physical principles to model electron distributions, energy landscapes, and probabilistic ensembles, often validated against empirical data for refinement.^[56] In quantum chemistry, density functional theory (DFT) serves as a cornerstone for determining molecular compositions and stable structures by computing ground-state electron densities. The Hohenberg-Kohn theorems establish that the electron density \rho(\mathbf{r}) uniquely determines all molecular properties, including composition, while the Kohn-Sham equations map the interacting system to a non-interacting reference with the same density, minimizing the energy functional:

E[\rho] = T_s[\rho] + \int V_{\text{ext}}(\mathbf{r}) \rho(\mathbf{r}) \, d\mathbf{r} + \frac{1}{2} \int \frac{\rho(\mathbf{r}) \rho(\mathbf{r}')}{|\mathbf{r} - \mathbf{r}'|} \, d\mathbf{r} d\mathbf{r}' + E_{\text{xc}}[\rho],

where T_s[\rho] is the non-interacting kinetic energy, V_{\text{ext}} is the external potential, the third term is the Hartree energy, and E_{\text{xc}}[\rho] is the approximate exchange-correlation functional.^[57] This approach predicts bond lengths and geometries with errors typically under 5 pm for transition metal complexes, facilitating composition optimization in organic and inorganic molecules.^[58] Popular functionals like B3LYP and TPSSh balance accuracy and computational cost, enabling predictions for systems up to thousands of atoms.^[59] Thermodynamic modeling employs Gibbs free energy minimization to forecast phase diagrams and optimal alloy compositions, with the CALPHAD method providing a systematic framework for multicomponent systems. CALPHAD assesses thermodynamic parameters from experimental and ab initio data, modeling the molar Gibbs energy of each phase as G_m^\phi = \sum_i x_i {}^0G_i^\phi + RT \sum_i x_i \ln x_i + {}^\text{ex}G_m^\phi + \sum_{p=1}^P RT \ln(1 + a_T^e \cdot \exp(p \cdot h_T)), where x_i are site fractions, {}^0G_i^\phi are reference energies, and excess terms account for interactions.^[60] By minimizing the total Gibbs energy G = \sum_\phi n^\phi G_m^\phi, it predicts stable phases and compositions in alloys like Ni-based superalloys, with applications in materials design since the 1970s. The compound energy formalism handles non-stoichiometric phases via sublattice models, improving accuracy for complex alloys. Statistical mechanics provides ensemble-based predictions of mixture compositions through averages over probabilistic distributions, particularly via the Boltzmann distribution for ideal gases. In the canonical ensemble, the probability of a state with energy E_n is p(n) = e^{-\beta E_n}/Z, where \beta = 1/k_B T and Z is the partition function, yielding average compositions as \langle N_i \rangle = \sum N_i p(n).^[61] For ideal gas mixtures, the total partition function factors as Z = \prod_i (V^{N_i} / N_i! \lambda_i^{3N_i}), resolving mixing entropy via indistinguishability and predicting mole fractions proportional to fugacities.^[61] This approach underpins calculations of partial pressures and diffusion in gaseous mixtures, with extensions to grand canonical ensembles for open systems.^[62] Post-2010 advancements in machine learning (ML) have enhanced composition prediction by integrating spectral data and databases, accelerating materials discovery. Supervised models like random forests and neural networks train on datasets from the Materials Project to infer compositions yielding target properties, such as bandgaps in perovskites from DFT-derived spectra. For instance, active learning loops iteratively refine predictions, identifying viable hybrid organic-inorganic perovskite compositions for photovoltaics from over 5,000 candidates. Graph neural networks process spectral fingerprints to reverse-engineer alloy compositions, outperforming traditional methods in high-throughput screening.^[63] More recent developments as of 2025 include generative AI methods for sampling molecular structures across chemical species and developing force fields, as well as data-driven models predicting multi-component oxide compositions from pseudo-binary data, enabling faster discovery of novel materials like high-entropy alloys.^[64]^[65]^[66] These techniques, often physics-informed, reduce computational costs compared to pure DFT while enabling discovery of novel materials like high-entropy alloys. Despite their strengths, theoretical approaches face limitations from model assumptions, such as ideal behavior in statistical mechanics neglecting interparticle interactions in real gases, leading to deviations in non-ideal mixtures.^[61] DFT's reliance on approximate E_{\text{xc}} functionals introduces errors in energy predictions up to 0.1-0.3 eV for alloys, affecting composition stability assessments.^[67] CALPHAD models depend on extrapolated experimental data, potentially underestimating short-range ordering in multicomponent systems. ML methods suffer from biases in training databases, overfitting to spectral noise, and limited generalizability beyond represented chemistries, necessitating hybrid validation.

Applications

Materials Science

In materials science, the chemical composition of engineered substances fundamentally dictates their mechanical, electrical, thermal, and chemical properties, enabling tailored performance for technological applications. By precisely controlling the types and proportions of elements or molecules, scientists can enhance attributes such as strength, ductility, conductivity, and reactivity, often through alloying, doping, or copolymerization. For instance, the addition of specific impurities or alloying elements alters the microstructure and electronic structure, directly influencing how materials respond to stress, temperature, or electric fields.^[68]^[69] A prime example is the doping of semiconductors, where introducing phosphorus impurities into silicon creates n-type materials with enhanced electrical conductivity. Phosphorus, having five valence electrons compared to silicon's four, donates an extra electron to the conduction band, increasing charge carrier density and enabling applications in electronics like transistors. In metals, composition critically affects mechanical properties; for steels, carbon content ranging from 0.02% to 2.1% by weight determines the balance between ductility and hardness, with low-carbon variants (<0.25%) offering high ductility for forming processes and high-carbon ones (>0.60%) providing superior hardness for tools. Alloying stainless steels with approximately 18% chromium and 8% nickel further improves corrosion resistance by forming a passive oxide layer while maintaining austenitic structure for toughness.^[70]^[71]^[72]^[73] In polymers, monomer composition in copolymers like styrene-butadiene rubber (SBR) tunes elasticity for specific uses, such as tire treads. Typical SBR formulations feature a 25% styrene to 75% butadiene ratio, where higher butadiene content promotes chain flexibility and resilience, contributing to improved abrasion resistance and energy dissipation under dynamic loading. For nanomaterials, surface composition plays a pivotal role; gold nanoparticles functionalized with thiol ligands exhibit modified reactivity due to the formation of stable Au-S bonds, which passivate the surface, prevent aggregation, and allow selective conjugation with biomolecules, enhancing applications in catalysis and sensing.^[74] A notable historical milestone in compositional design occurred in the 2010s with the development of high-entropy alloys (HEAs), which incorporate multiple principal elements in near-equal proportions (typically 5–35 at.%) to maximize configurational entropy and stabilize single-phase solid solutions. This approach, building on earlier concepts, led to alloys with exceptional strength-ductility combinations at high temperatures, surpassing traditional alloys in aerospace and energy sectors by leveraging lattice distortion and sluggish diffusion effects.^[75]

Environmental Analysis

The chemical composition of Earth's atmosphere is dominated by nitrogen (N₂) at approximately 78% by volume, oxygen (O₂) at 21%, and argon (Ar) at 0.93%, with the remainder consisting of trace gases such as carbon dioxide (CO₂), neon, and methane.^[76] Atmospheric pollutants significantly alter this baseline, including elevated CO₂ levels that have continued to rise, with global monthly means reaching 422.95 ppm in August 2025 (the most recent available as of November 2025), near the seasonal low, while peaks earlier in the year exceeded 430 ppm at key observatories, reflecting ongoing anthropogenic increases from fossil fuel combustion and deforestation.^[77] Fine particulate matter (PM2.5), a key air pollutant, primarily comprises sulfates, nitrates, ammonium, elemental carbon, organic carbon, and crustal materials, with sulfates and nitrates often deriving from sulfur and nitrogen oxide emissions.^[78] In water systems, chemical composition analysis focuses on dissolved ions and contaminants that affect quality and ecosystem health. Water hardness, primarily caused by calcium (Ca²⁺) and magnesium (Mg²⁺) ions, is typically measured in milligrams per liter (mg/L) as calcium carbonate equivalents, with levels classified as soft (0–60 mg/L), moderately hard (61–120 mg/L), hard (121–180 mg/L), and very hard (>180 mg/L); for instance, many U.S. groundwater sources exceed 120 mg/L due to geological influences.^[79] Organic contaminants like polychlorinated biphenyls (PCBs), persistent industrial pollutants, accumulate in sediments, where they bind to organic matter and pose bioaccumulation risks in aquatic food chains.^[80] Soil chemical composition varies by parent material and weathering but generally features silicon (Si) at about 31.5%, aluminum (Al) at 7.2%, and iron (Fe) at 1.8% by weight in U.S. soils, often present as oxides that influence soil structure and fertility.^[81] Essential nutrients include nitrogen (N) at roughly 0.1–0.2% total content, primarily in organic forms tied to soil organic matter;^[82] phosphorus (P) at around 600 ppm; and potassium (K) at 1.2%, which support plant growth but can become limiting in intensively farmed areas.^[81] Contamination from heavy metals, such as lead (Pb), elevates levels beyond natural baselines (often <20 ppm) to 200–400 ppm in urban or industrial soils, stemming from historical paint, gasoline, and waste disposal.^[83] Isotopic analysis of ice cores provides insights into past environmental conditions through variations in oxygen-18 (δ¹⁸O) ratios, where lower δ¹⁸O values indicate colder temperatures due to fractionation effects during precipitation; for example, Greenland and Antarctic cores reveal glacial-interglacial cycles over 800,000 years, linking atmospheric composition changes to global climate shifts.^[84] Regulatory frameworks guide environmental monitoring, with the U.S. Environmental Protection Agency (EPA) enforcing a maximum contaminant level of 10 parts per billion (ppb) for arsenic in drinking water to mitigate health risks from natural and anthropogenic sources.^[85] Analytical techniques, such as spectroscopy, are applied to these samples for precise quantification.^[86]

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Energy Dispersive X-Ray Spectroscopy | EDS Analysis
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Do you have information about water hardness in the United States?
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EPA recommends removing PCB-containing FLBs from buildings as soon as possible to prevent potential inhalation or dermal exposure. Even intact PCB-containing ...
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