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Chemosis

Chemosis is a medical condition characterized by the edema or swelling of the conjunctiva, the thin, transparent mucous membrane that lines the inner surface of the eyelids and covers the anterior portion of the sclera, often presenting as a blister-like or fluid-filled protrusion on the ocular surface.^[1] This swelling results from the accumulation of fluid in the conjunctival tissues, typically indicating underlying irritation or inflammation of the eye.^[1] Chemosis arises from a variety of etiologies, most commonly allergic reactions, which trigger an inflammatory response in the conjunctiva leading to vascular permeability and fluid leakage.^[2] Infectious causes, including bacterial or viral conjunctivitis, can also induce chemosis through inflammatory mediators.^[3] Additionally, it may occur secondary to trauma, such as blunt injury to the eye, or as a complication following ocular surgeries like blepharoplasty, where disruption of lymphatic drainage contributes to persistent edema.^[4] Other factors include exposure to irritants, certain medications, or systemic conditions like superior vena cava syndrome, though these are less frequent.^[5] Clinically, chemosis manifests primarily as visible conjunctival swelling that can range from mild to severe, sometimes forming a tense, gelatinous elevation that separates the conjunctiva from the underlying sclera.^[6] Accompanying symptoms often include ocular irritation, foreign body sensation, excessive tearing, photophobia, and in cases of significant swelling, difficulty closing the eyelids (lagophthalmos), which may lead to corneal exposure and dryness.^[1] Unlike scleritis, chemosis is generally painless and non-tender, though associated redness or itching may occur depending on the cause.^[7] Diagnosis is primarily clinical, involving a detailed history to ascertain onset, exposures, and systemic symptoms, supplemented by slit-lamp biomicroscopy to assess the extent of swelling and rule out differentials like orbital cellulitis or thyroid eye disease.^[3] Management of chemosis is tailored to the underlying etiology and severity. For allergic causes, topical antihistamines, mast cell stabilizers, or corticosteroids, along with cool compresses, effectively reduce inflammation and edema.^[2] Infectious chemosis requires targeted antimicrobial therapy, such as topical antibiotics for bacterial cases or supportive care for viral etiologies.^[8] In postoperative scenarios, conservative measures like preservative-free lubricants, hypertonic saline drops, and taping the eyelid at night are initial steps, with escalation to subconjunctival steroids or surgical techniques like conjunctival resection for refractory cases.^[9] Early intervention is crucial to prevent complications such as secondary infection, corneal abrasion, or chronic exposure keratopathy, and the prognosis is favorable with prompt treatment, often resolving within days to weeks.^[1]

Definition and Characteristics

Definition

Chemosis is defined as the swelling or edema of the conjunctiva, the thin, transparent membrane that lines the inner surface of the eyelids and covers the white part of the eye (sclera), resulting from the accumulation of fluid in the conjunctival tissues. This condition manifests as a blister-like protrusion of the conjunctiva that extends beyond the corneal limbus, the border between the cornea and sclera, giving the eye a characteristic puffy or gelatinous appearance.^[10] The term "chemosis" originates from the Greek word "cheme," meaning cockleshell, alluding to the shelled or blistering resemblance of the swollen conjunctiva to a cockle shell. This etymological reference highlights the visible, outward-bulging feature that distinguishes the condition in clinical observation.^[11] Chemosis specifically involves the buildup of transudative or exudative fluid within the conjunctival layers due to increased vascular permeability, differing from related ocular conditions such as bulbar conjunctival injection, which refers to redness caused by dilation of conjunctival blood vessels without swelling, or subconjunctival hemorrhage, which entails the accumulation of blood beneath the conjunctiva resulting in a flat, bright red patch rather than edematous protrusion.^[10]^[12]^[13]

Clinical Features

Chemosis manifests as a prominent, blister-like swelling of the conjunctiva, the thin membrane covering the white of the eye and inner eyelids, resulting from fluid accumulation that imparts a gelatinous or inflated appearance.^[10]^[14] This edema often localizes to the limbal region near the corneal border, creating a bulging effect, and it can affect one eye (unilateral) or both eyes (bilateral) depending on the extent of involvement.^[15]^[16] Clinicians grade chemosis based on the degree of conjunctival protrusion and involvement to assess severity and guide monitoring. Mild chemosis involves slight limbal elevation with minimal fluid accumulation and limited protrusion. Moderate chemosis features extension of the swelling 3-5 mm beyond the limbus, with noticeable billowing and moderate conjunctival protrusion. Severe chemosis presents as full ballooning of the conjunctiva, marked edema exceeding 5 mm, and significant protrusion that may impair eyelid closure and raise the risk of corneal exposure.^[17] The condition typically causes blurred vision due to irregularity of the ocular surface from the swollen conjunctiva, though it is generally painless without secondary irritation or complications.^[18]^[7] This visual disturbance arises from the pathophysiological edema disrupting tear film stability, as detailed in the mechanisms of edema section.

Pathophysiology

Mechanisms of Edema

Chemosis arises primarily from increased vascular permeability in the conjunctival capillaries, which allows the transudation of plasma proteins and fluid into the interstitial spaces, resulting in localized swelling. This permeability is often triggered by histamine release from mast cells, particularly in allergic responses, leading to endothelial cell contraction and gaps in the vascular barrier. Cytokine mediation, such as through interleukin-6 (IL-6), further promotes endothelial dysfunction and leakage by activating signaling pathways that disrupt tight junctions. Endothelial damage from direct insult, such as in trauma or infection, also contributes by compromising the integrity of the capillary wall, facilitating fluid extravasation.^[19]^[20]^[21] The fluid dynamics underlying this edema follow Starling's principle, where an imbalance between hydrostatic and oncotic pressures drives net fluid movement out of the capillaries into the tissue. Elevated hydrostatic pressure within conjunctival vessels, often due to inflammation-induced vasodilation, pushes fluid outward, while reduced oncotic pressure from protein leakage fails to draw it back. This process is exacerbated by impaired lymphatic drainage in the conjunctiva, which normally reabsorbs excess interstitial fluid; obstruction or overload from swelling creates a cycle of accumulation without deeper orbital extension.^[22]^[23] In the inflammatory cascade, mast cell degranulation in allergic chemosis releases histamine and other mediators that initiate acute permeability changes and recruit additional inflammatory cells. In infectious cases, bacterial endotoxins trigger a similar cascade by stimulating cytokine production from resident immune cells, amplifying vascular leakage and edema while confining the response to the superficial conjunctiva. These mechanisms ensure the edema remains localized, distinguishing chemosis from more invasive orbital pathologies.^[24]^[25]

Anatomical Involvement

The conjunctiva is a thin, transparent mucous membrane that lines the inner surface of the eyelids (palpebral conjunctiva) and covers the anterior portion of the sclera (bulbar conjunctiva), extending from the corneal limbus to the fornices.^[26] It consists of a non-keratinized stratified squamous epithelium, typically five to six cell layers thick, overlying a vascularized substantia propria (stroma) that includes fibroblasts, immune cells, and accessory lacrimal glands.^[27] Embedded within the epithelium are goblet cells, which secrete mucin to contribute to the tear film's mucoid layer, ensuring ocular surface lubrication and stability.^[27] In chemosis, the condition primarily affects the bulbar conjunctiva, particularly the region adjacent to the limbus, where edema causes visible swelling and protrusion.^[6] Severe cases may extend to the fornices, leading to pooling of fluid in these recessed areas, but deeper structures such as Tenon's capsule are generally spared unless the edema is advanced and persistent.^[6] Normally, the conjunctiva serves as a protective barrier against microbial invasion and environmental irritants while maintaining tear film integrity through mucus production and smooth gliding of the eyelids over the ocular surface.^[27] Chemosis disrupts these functions by mechanically interfering with eyelid movement and tear distribution, potentially leading to exposure and further surface instability.^[28] This anatomical involvement arises from localized edema, as explored in the mechanisms of edema section.

Etiology

Allergic and Inflammatory Causes

Chemosis frequently arises from allergic reactions mediated by type I hypersensitivity, where exposure to environmental allergens triggers mast cell degranulation and subsequent vascular permeability in the conjunctiva. Common triggers include airborne allergens such as pollen in seasonal allergic conjunctivitis (SAC) and perennial allergens like dust mites or animal dander in non-seasonal forms, leading to conjunctival edema as fluid leaks into the tissue. Contact lens wear can exacerbate this through mechanical irritation combined with hypersensitivity to lens deposits or solutions, often manifesting as giant papillary conjunctivitis with prominent chemosis. In atopic individuals, angioedema variants may contribute, where deeper tissue swelling extends to the periorbital region, amplifying conjunctival involvement.^[29]^[30]^[31]^[32] Inflammatory conditions represent another key non-infectious etiology, often involving chronic immune activation. Vernal keratoconjunctivitis (VKC), a severe allergic disorder prevalent in young males with atopy, features recurrent episodes of conjunctival inflammation with marked chemosis, hyperemia, and mucous discharge due to Th2-mediated responses. Atopic keratoconjunctivitis (AKC), associated with systemic atopic dermatitis, similarly presents with persistent bulbar conjunctival chemosis alongside frequent corneal involvement. Thyroid eye disease (TED), or Graves' ophthalmopathy, is an autoimmune inflammatory process linked to hyperthyroidism, where orbital fibroblasts produce excess glycosaminoglycans that retain water, causing periorbital and conjunctival edema including chemosis in moderate to severe cases. Superior limbic keratoconjunctivitis (SLK), a chronic inflammatory disorder of unclear etiology but possibly linked to mechanical friction or autoimmunity, involves superior bulbar conjunctival redundancy and edema that can manifest as localized chemosis. These allergic and inflammatory triggers are prevalent in ocular allergy presentations, particularly during peak seasonal exposure.^[33]^[34]^[35]^[36]

Infectious Causes

Infectious causes of chemosis primarily involve microbial pathogens that provoke conjunctival edema through direct invasion, inflammation, or toxin production. Bacterial infections, such as acute bacterial conjunctivitis, are common culprits, often presenting with purulent discharge and conjunctival swelling.^[16]^[37] Common pathogens include Staphylococcus aureus and Haemophilus influenzae, which lead to hyperemia, chemosis, and mucopurulent exudate, typically resolving with topical antibiotics but potentially progressing to more severe involvement if untreated.^[38]^[37] In severe cases, bacterial infections can extend to orbital cellulitis, where chemosis accompanies proptosis, ophthalmoplegia, and eyelid edema due to intraorbital pressure elevation from contiguous spread, often requiring systemic antibiotics and possible surgical intervention.^[39]^[40] Viral infections frequently induce chemosis via epithelial disruption and immune-mediated responses. Adenoviral keratoconjunctivitis, including epidemic keratoconjunctivitis, manifests with bilateral conjunctival injection, chemosis, watery discharge, and preauricular lymphadenopathy, affecting up to 90% of viral conjunctivitis cases and spreading rapidly through contaminated surfaces.^[41]^[42] Herpes simplex virus involvement typically presents as unilateral follicular conjunctivitis with chemosis, vesicular lid lesions, and potential corneal dendrites, necessitating antiviral therapy to prevent keratitis progression.^[16]^[43] Other infections include chlamydial causes, such as Chlamydia trachomatis-induced inclusion conjunctivitis or trachoma, where chronic or recurrent exposure leads to follicular conjunctivitis, hyperemia, and chemosis, particularly in endemic areas or sexually active adults.^[44]^[45] Fungal infections, though rarer, occur in immunocompromised patients and can cause chemosis through keratitis or orbital extension, often involving Aspergillus or Candida species following trauma or systemic immunosuppression, with outcomes dependent on early antifungal therapy.^[46]^[47] Since 2020, COVID-19-associated conjunctivitis has shown increased incidence of viral chemosis, with symptoms like hyperemia and epiphora in up to 31% of cases, linked to SARS-CoV-2 direct ocular tropism.^[48]^[49]

Traumatic and Other Causes

Traumatic causes of chemosis involve direct mechanical or chemical injury to the ocular surface, leading to conjunctival edema through disruption of vascular integrity and inflammatory mediator release, such as histamine and bradykinin.^[21] Blunt trauma, for instance, can result in chemosis disproportionate to other signs, potentially indicating underlying scleral rupture, as seen in a case of a patient sustaining injury from sleep-walking into a dresser, where chemosis resolved over one month with supportive measures like tarsorrhaphy.^[21] Chemical burns, particularly from alkalis responsible for approximately 60% of such injuries, cause immediate conjunctival swelling due to tissue penetration and osmotic effects, often requiring urgent irrigation and monitoring for deeper damage.^[50] Foreign body irritation similarly provokes chemosis via localized trauma and secondary inflammation, as documented in cases of mechanical insult leading to conjunctival edema without infection.^[23] Surgical trauma represents a common iatrogenic etiology, where manipulation of periocular tissues disrupts lymphatic drainage and increases vascular permeability, resulting in persistent chemosis. Following lower eyelid blepharoplasty, chemosis occurs in approximately 26% of cases, with increased risk when intraoperative canthopexy is performed.^[51]^[6] In strabismus surgery, chemosis arises from conjunctival incision and traction, typically resolving spontaneously but occasionally requiring intervention if chronic.^[52] Contact lens overwear can induce iatrogenic chemosis through corneal hypoxia and epithelial compromise, often complicating bacterial keratitis with associated conjunctival edema in extended-wear users.^[53] Systemic conditions contribute to chemosis by promoting generalized fluid retention or venous congestion, exploiting the conjunctiva's anatomical vulnerability to edema. Superior vena cava syndrome, caused by obstruction from malignancy or thrombosis, leads to conjunctival chemosis through elevated venous pressure and facial edema, manifesting as a key diagnostic sign alongside neck vein distension.^[5] In renal failure with fluid overload, such as nephrotic syndrome, hypoproteinemia drives severe periorbital and conjunctival edema, with chemosis resolving upon diuresis and protein restoration.^[54] Exposure keratopathy in comatose or critically ill patients, particularly those on mechanical ventilation, is frequently associated with chemosis, which occurs in 26.9% of such patients.^[55]^[56]

Clinical Presentation

Signs and Symptoms

Patients with chemosis typically experience a range of ocular symptoms, including itching, excessive tearing, a foreign body sensation, and photophobia, which contribute to overall eye discomfort.^[10]^[57]^[58] Unlike conditions involving severe ocular pain, chemosis is generally associated with mild to moderate irritation rather than intense pain.^[10]^[59] Observable signs include swelling of the conjunctiva, which may appear as a blister-like protrusion on the white of the eye, often accompanied by conjunctival injection (redness) and synergistic eyelid swelling.^[60]^[57]^[18] In more severe cases, the swelling can lead to pseudoptosis, where the upper eyelid appears to droop due to the mechanical effects of the edema, and lagophthalmos (inability to fully close the eyelids), increasing the risk of corneal exposure.^[57]^[1] The duration of chemosis manifestations can vary significantly, with acute presentations resolving within hours to days, whereas chronic forms may persist for weeks.^[57] Clinical grading systems assess the severity of these signs and symptoms based on the extent of swelling and associated features.^[18]

Associated Conditions

Chemosis frequently co-occurs with dry eye syndrome, where the conjunctival edema can exacerbate symptoms by disrupting tear film stability and increasing evaporative loss, potentially leading to a vicious cycle of ocular surface irritation.^[61] Additionally, the mechanical pressure from swollen conjunctiva may heighten the risk of corneal abrasion through friction against the eyelid or exposure due to incomplete closure.^[62] Systemic conditions linked to chemosis include autoimmune disorders such as Sjögren's syndrome, which often presents with severe dry eye that can manifest or worsen as conjunctival edema due to lacrimal gland dysfunction.^[63] Malignancy-related associations, particularly orbital tumors like choroidal melanoma or metastatic breast carcinoma, can cause chemosis through mass effect, venous obstruction, or inflammation in the orbit.^[64] Post-surgical states, especially following blepharoplasty or other eyelid procedures, commonly feature chemosis as a result of lymphatic disruption and transient edema.^[6] Epidemiologically, chemosis shows higher incidence in pediatric groups with atopy, such as those with vernal keratoconjunctivitis, where allergic inflammation drives conjunctival swelling.^[65]

Diagnosis

History and Examination

The clinical assessment of chemosis begins with a detailed patient history to identify potential triggers and associated factors. Clinicians inquire about the onset and duration of symptoms, noting whether the swelling appeared acutely (e.g., within hours to days, as in allergic reactions or trauma) or subacutely (e.g., over weeks, suggesting chronic inflammation). Questions focus on possible exposures, including recent contact with allergens such as pollen, dust, or pet dander, particularly in patients with a history of atopy or seasonal patterns. Recent infections, such as upper respiratory illnesses or exposure to individuals with conjunctivitis, are explored, along with any history of ocular trauma, including rubbing, surgery, or foreign body contact. Systemic symptoms like fever, rash, pruritus, or respiratory issues are also elicited to contextualize the presentation.^[3]^[2]^[66] The physical examination starts with an external assessment of the eyelids and periorbital area for edema, erythema, or discharge, followed by evaluation of the conjunctiva for visible swelling. Slit-lamp biomicroscopy is essential to magnify and assess the extent of chemosis, revealing conjunctival edema that may appear as blister-like protrusions, often graded qualitatively as mild (localized), moderate (extending over the limbus), or severe (ballooning with forniceal involvement). This examination also identifies associated injection, papillary changes, or follicular reactions. Fluorescein staining is applied to detect any epithelial defects on the cornea or conjunctiva, which may indicate secondary complications like erosions. An everted eyelid examination is performed to inspect the tarsal and forniceal conjunctiva for hidden involvement, such as giant papillae or symblepharon in severe cases.^[2]^[3] Red flags during history and examination warrant urgent evaluation for orbital or deeper involvement. These include acute vision loss, which may signal corneal compromise; proptosis or eyelid lag, suggestive of orbital inflammation or mass effect; and restricted extraocular motility, indicating possible entrapment or neuropathy. The presence of severe pain, fever, or unilateral proptosis further heightens concern for infectious or compressive etiologies.^[3]^[2]^[66]

Differential Diagnosis

Chemosis, characterized by edema and ballooning of the conjunctiva at the limbus, must be differentiated from conditions presenting with similar periorbital or conjunctival swelling to ensure accurate diagnosis.^[10] Conjunctival prolapse, particularly in children, can mimic chemosis through localized conjunctival redundancy and exposure but lacks the diffuse limbal ballooning typical of chemosis; it often results from laxity or trauma without the blister-like transudation seen in chemosis.^[67] Orbital pseudotumor, or idiopathic orbital inflammation, may present with chemosis alongside proptosis, pain, and restricted motility due to deeper orbital involvement, distinguishing it from isolated superficial chemosis through systemic inflammatory markers and imaging findings. Allergic lid edema, involving periorbital swelling from histamine release, can resemble chemosis but is differentiated by predominant eyelid involvement without prominent conjunctival elevation at the limbus and by response to antihistamines.^[68] Diagnostic aids play a crucial role in excluding mimics. For suspected infectious causes, conjunctival swab cultures help identify bacterial pathogens in cases of purulent discharge accompanying swelling, guiding differentiation from noninfectious edema.^[69] Orbital computed tomography (CT) or magnetic resonance imaging (MRI) is essential for deeper involvement, revealing proptosis, extraocular muscle enlargement, or abscesses in orbital pseudotumor or cellulitis that may simulate chemosis, whereas isolated chemosis shows no such orbital changes.^[70] Allergy testing, including skin prick tests or serum immunoglobulin E (IgE) levels, confirms IgE-mediated reactions in allergic differentials, with elevated tear or serum IgE supporting allergic etiology over other causes.^[71] Rare mimics include lymphangioma or amyloidosis presenting with cystic conjunctival swellings that resemble chemosis but feature persistent, non-pitting lesions; lymphangioma often shows grape-like vesicles, while amyloid deposits may calcify, confirmed via biopsy.^[72] In the 2020s, distinguishing chemosis from long COVID ocular effects, such as persistent conjunctival hyperemia or edema from post-viral inflammation, relies on history of recent SARS-CoV-2 infection and resolution patterns, as long COVID may involve low-grade inflammation without acute triggers.^[48]

Management

Supportive Measures

Supportive measures for chemosis focus on alleviating discomfort and preventing complications through non-invasive, general strategies applicable across etiologies. Cold compresses, applied gently to the closed eyelids for 10-15 minutes several times daily, can reduce vasodilation and swelling by constricting blood vessels and limiting fluid accumulation in the conjunctiva.^[10] Artificial tears or lubricating ointments provide essential moisture to the ocular surface, countering dryness and irritation that may exacerbate the condition.^[59] In cases where incomplete eyelid closure occurs, taping the upper eyelid to the forehead or brow at night helps protect the cornea from exposure and promotes better fluid drainage.^[73] Lifestyle modifications play a key role in minimizing symptom progression. Patients should avoid environmental irritants such as smoke, wind, dust, and allergens, which can worsen conjunctival edema by triggering further inflammation.^[58] Elevating the head during sleep, using an extra pillow to maintain a 30-45 degree angle, reduces fluid pooling in the periorbital tissues overnight.^[74] Regular monitoring is essential to track resolution and detect any worsening, particularly in bilateral chemosis where systemic involvement may be present. Follow-up examinations every 1-2 weeks allow for assessment of symptom persistence and adjustment of care as needed.^[75]

Cause-Specific Interventions

For allergic causes of chemosis, treatment targets the underlying hypersensitivity reaction in the conjunctiva. Topical antihistamines, such as olopatadine hydrochloride 0.1% or 0.2% administered twice daily, effectively alleviate symptoms including chemosis by blocking histamine H1 receptors and reducing vascular permeability.^[76] Dual-action agents like olopatadine also stabilize mast cells, preventing further mediator release and providing rapid relief from conjunctival edema in seasonal or perennial allergic conjunctivitis.^[71] Mast cell stabilizers, including cromolyn sodium 4% used four times daily or nedocromil sodium 2% twice daily, are recommended for prophylactic management in mild to moderate cases to inhibit degranulation and limit chemosis recurrence.^[77] In severe or refractory flares, short courses of oral corticosteroids may be employed under specialist supervision to control intense inflammation, though monitoring for systemic side effects is essential.^[78] Infectious etiologies require etiology-specific antimicrobial therapy to eradicate pathogens and resolve secondary chemosis. For bacterial infections, such as those caused by Staphylococcus or Streptococcus species leading to purulent conjunctivitis, topical antibiotic drops like erythromycin 0.5% ointment applied four times daily for 5-7 days are a first-line option, promoting rapid microbial clearance and reduction in conjunctival swelling.^[79] Broader-spectrum agents, such as fluoroquinolone drops (e.g., moxifloxacin 0.5%), may be used if resistance is suspected. For viral causes, particularly herpes simplex virus (HSV)-associated keratoconjunctivitis, topical antivirals like ganciclovir 0.15% gel applied five times daily for 7 days target viral replication and mitigate chemosis, with evidence of faster epithelial healing compared to supportive care alone.^[80] Adenoviral conjunctivitis often self-resolves within 1-2 weeks, but supportive antivirals like ganciclovir may shorten shedding duration in severe cases; systemic acyclovir is reserved for immunocompromised patients or neurotrophic keratitis.^[81] For postoperative chemosis, commonly following procedures like blepharoplasty due to lymphatic disruption, initial management builds on supportive measures with additions such as hypertonic saline drops to draw out fluid and topical corticosteroids to reduce inflammation.^[9] For persistent cases, options include subconjunctival steroid injections or surgical interventions like conjunctival resection or cauterization to restore drainage and resolve refractory edema.^[9]^[4] For other causes, interventions address the primary insult to prevent persistent chemosis. In traumatic cases involving conjunctival laceration or edema from blunt injury, surgical debridement of devitalized tissue under local anesthesia facilitates healing and reduces fluid accumulation, particularly if necrosis or foreign bodies are present. For systemic fluid overload, such as in congestive heart failure or renal disease, loop diuretics like furosemide 20-40 mg orally or intravenously once or twice daily help alleviate generalized edema including periorbital chemosis by promoting diuresis and restoring fluid balance.^[82]

Prognosis

Typical Course

The typical course of chemosis varies based on its underlying etiology, with most cases following an acute pattern of onset and resolution, while others exhibit chronic persistence or recurrent episodes. In acute scenarios, such as those triggered by allergic conjunctivitis, symptoms often improve within 1 to 7 days following initiation of treatment with antihistamines, mast cell stabilizers, or short-term topical corticosteroids, though mild cases may resolve in hours to days upon allergen avoidance. Infectious causes, including bacterial or viral conjunctivitis, generally require 7 to 14 days for resolution, with bacterial forms responding to a 7- to 10-day course of antibiotic drops and viral cases self-limiting over 1 to 2 weeks. Early intervention with targeted therapies, such as anti-inflammatory agents, can shorten these durations by addressing the inflammatory cascade promptly. Chronic patterns are observed in systemic or allergic disorders like untreated thyroid eye disease, where chemosis may persist for months to years during the active inflammatory phase, potentially stabilizing after 18 months but leaving residual orbital changes if unmanaged. In vernal keratoconjunctivitis, a recurrent allergic condition, chemosis contributes to a perennial course with seasonal exacerbations tied to environmental triggers like pollen, affecting young males predominantly and persisting beyond puberty in approximately 12% of cases despite treatment. Untreated severe instances across etiologies heighten the risk of progression to secondary issues, underscoring the importance of timely management to alter the disease trajectory.

Complications

Severe or prolonged chemosis can impair eyelid closure, leading to corneal exposure and subsequent exposure keratopathy, a condition where the cornea dries out and becomes vulnerable to damage.^[83] This exposure increases the risk of corneal ulceration, particularly in cases where chemosis causes significant lagophthalmos (incomplete eyelid closure).^[84] Secondary bacterial superinfection may develop as a complication, progressing to infectious keratitis if the compromised ocular surface allows bacterial invasion.^[85] In chronic or severe instances, persistent inflammation from chemosis can contribute to symblepharon, the formation of adhesions between the conjunctiva and cornea or other conjunctival surfaces.^[86] Chemosis may serve as an indicator of underlying systemic conditions, including vasculitis or malignancy, especially when accompanied by proptosis, ophthalmoplegia, or vision changes.^[87] In such cases, orbital involvement can rarely lead to vision-threatening complications like optic nerve compression or severe intraocular pressure elevation.^[88] Recent data highlight an elevated risk of complications from chemosis in aging populations, particularly those with dry eye comorbidities, where reduced tear film stability and delayed epithelial healing exacerbate corneal exposure and ulceration risks.^[89]^[62]

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Bacterial conjunctivitis is usually caused by Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus species, Moraxella catarrhalis or, less commonly, ...
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... cellulitis does not involve the globe itself. Although orbital cellulitis ... Chemosis (conjunctival swelling) is more commonly present in orbital cellulitis ...
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Conjunctivitis causes the eye to appear erythematous secondary to the dilation of blood vessels and is usually accompanied by increased tearing and/or mucoid ...<|control11|><|separator|>
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Treatment · In limited studies, antiviral ganciclovir gel has been shown to shorten the duration of EKC and reduce the development of subepithelial infiltrates.
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May 6, 2024 · In advanced cases, patients may present with chemosis (see Image. Chemosis) or follicular conjunctivitis (see Image. Follicular Conjunctivitis).
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A total of 12 of 38 patients (31.6%; 95% CI, 17.5-48.7) had ocular manifestations consistent with conjunctivitis, including conjunctival hyperemia, chemosis, ...
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The various signs of bacterial keratitis are lid edema, blepharospasm, matting of eyelashes, purulent discharge, conjunctival chemosis, circumcorneal congestion ...
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Understandably, the swollen plethoric face, the conjunctival edema of chemosis, and the distended neck veins and collaterals that indicate superior vena.
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Characteristics and associated risk factors of exposure keratopathy ...
Apr 11, 2025 · Of 156 ventilated patients included in this study, 42.3% had exposure keratopathy, 13.5% had lagophthalmos, and 26.9% of patients had chemosis.
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Chemosis is swelling of the eye surface membranes because of accumulation of fluid. This symptom is often related to an allergic response.
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Chemosis is closely related to dry eye disease, because severe and persistent chemosis may destroy the goblet cells, thereby resulting in unstable tear film ...<|separator|>
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The purpose of this article is to illustrate that in addition to dry eye, SS can cause serious, vision-threatening extraglandular ocular manifestations.
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The massive chemosis presented in our case was surely the most striking manifestation of the tumor. Unlike retinoblastoma, which is known to manifest with ...
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OSD affects a significant portion of the population, from 5% to 50%, and the prevalence increases with age. ... VKC is more frequent in tropical and dry climates ...<|control11|><|separator|>
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Sep 30, 2025 · Bacterial conjunctivitis Symptoms include massive exudation, severe chemosis, eyelid edema, marked conjunctival hyperemia, and if left ...Disease Entity · Pathophysiology · Diagnosis · Physical Examination
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Chemosis Information | Mount Sinai - New York
Chemosis is swelling of the eye surface membranes because of accumulation of fluid. This symptom is often related to an allergic response.
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The fine suspensory attachments of the conjunctival fornix may be disrupted by the hydraulic dissection of marked chemosis, leading to prolapse of the ...
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Jan 26, 2024 · Macropapillae, smaller than 1 mm in size, appear as flat-topped lesions with a polygonal (cobblestone-like) appearance. These macrophiles ...
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Jul 22, 2025 · In the diffuse form, there is swelling of the conjunctiva (chemosis), and the lymphatic vessels are spread out over a wide area. ... amyloidosis ...Missing: mimic | Show results with:mimic
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Conservative management includes applying moist dressings, eyelid taping, and pressure patching along with topical antibiotic and lubricants. Additionally, ...
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Chemosis After Blepharoplasty: Causes, Treatment, and Healing ...
May 28, 2025 · Chemosis. Gelatinous conjunctival swelling, may protrude over eyelid ; Conjunctivitis. Redness, discharge, often infectious or allergic in origin.
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Oct 13, 2025 · Follow-up Recommendations. Follow-up within 1-2 weeks is recommended if symptoms persist 2; For patients treated with topical corticosteroids ...
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Treatment of allergic conjunctivitis with olopatadine hydrochloride ...
Olopatadine hydrochloride ophthalmic solution has an excellent, strong, and safe anti-allergic effect in vitro and it provides superior clinical effectiveness ...
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Topical antihistamines and mast cell stabilisers reduce symptoms and signs of seasonal allergic conjunctivitis when compared with placebo in the short term.
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We report the use of dupilumab in a patient with AD, asthma and atopic keratoconjunctivitis (AKC) resulting in improvement in all three conditions.
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Ganciclovir ophthalmic gel, 0.15% is an effective and well tolerated antiviral treatment for superficial acute herpetic keratitis.
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Exposure Keratopathy - EyeWiki
Exposure Keratopathy. From EyeWiki. Jump to:navigation, search. All content on ... Assess for conjunctival injection or chemosis. Symptoms. Patients may ...
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Ophthalmology in Critical Care | Annals of the American Thoracic ...
Dec 3, 2018 · Another significant risk factor for developing exposure keratopathy is chemosis, or conjunctival edema, because it inhibits complete eyelid ...<|control11|><|separator|>
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The etiologic and pathogenic spectrum of exposure keratopathy
... corneal ulceration, stromal melting, and finally, superficial ... chemosis, lower Glasgow Coma Scale (GCS), and higher Acute Physiology and Chronic ...
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[PDF] CHRONIC CORNEAL DISEASES - CABI Digital Library
chemosis. Symblepharon is the adhesion of conjunctiva to itself or to the cornea. A corneal ulcer does not have to be present for symblepharon to occur.<|control11|><|separator|>
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Apr 21, 2024 · Patients presenting with decreased or double vision, ophthalmoplegia, chemosis, and proptosis should raise concerns for orbital malignancy.
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Jul 10, 2025 · Due to the rich vascular supply in the orbit, orbital vasculitis often presents with early symptoms, making it a critical sign of underlying, ...Disease Entity · Pathophysiology · Diagnosis · Etiological Presentations
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Jul 31, 2024 · This review comprehensively assesses risk factors, clinical characteristics, and management strategies for bacterial, viral, fungal, and acanthamoeba keratitis ...