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DPH

Diphenhydramine (DPH) is a first-generation H1 receptor antagonist antihistamine, developed in the 1940s, that blocks histamine action to alleviate allergic symptoms such as itching, sneezing, and hives, while also providing sedative, antiemetic, and antitussive effects through its penetration of the blood-brain barrier.^[1] Widely available over-the-counter as the active ingredient in products like Benadryl, it is commonly prescribed or self-administered for short-term relief of insomnia, motion sickness, vertigo, and extrapyramidal symptoms induced by antipsychotics.^[1] At therapeutic doses of 25-50 mg, it induces drowsiness and mild anticholinergic effects, but supratherapeutic ingestion exceeding 1 gram triggers anticholinergic toxicity characterized by delirium, vivid hallucinations, agitation, seizures, tachycardia, and urinary retention.^[2] DPH's recreational abuse, often termed "DPH tripping," stems from its ability to produce dissociative and hallucinogenic states at high doses, mimicking shadows or entities in users' peripheral vision, though empirical reports and clinical data emphasize the absence of euphoria and the predominance of dysphoric, nightmarish experiences.^[3]^[4] Overdose risks include QT prolongation leading to ventricular arrhythmias, hyperthermia, rhabdomyolysis, coma, and death, with case series documenting hospitalizations for psychosis-like symptoms that resolve only after cessation and supportive care such as benzodiazepines or physostigmine.^[2]^[4] Chronic misuse fosters tolerance, psychological dependence, and withdrawal manifesting as insomnia, anxiety, and cholinergic rebound, underscoring its potential for addiction despite limited opioid-like reinforcement.^[3] The U.S. Food and Drug Administration has highlighted these hazards, particularly from intentional high-dose consumption, which circumvents packaging limits through bulk purchases or extraction methods.^[4] Long-term therapeutic use, even at standard doses, correlates with increased dementia risk due to cumulative anticholinergic burden, prompting recommendations to favor second-generation alternatives like cetirizine where possible.^[5]

Government and Public Administration

Department of Public Health

The Department of Public Health (DPH) designates governmental agencies at the state or local level in the United States, such as those in Massachusetts (established 1869 as a board evolving into the modern DPH), Connecticut, Georgia, and Illinois, which oversee public health protection, promotion, and prevention efforts within their jurisdictions.^[6]^[7]^[8] These entities emerged in response to 19th-century challenges like urbanization, poor sanitation, and infectious disease outbreaks, with early models focusing on quarantine, water quality, and vital statistics collection to mitigate epidemics such as cholera and typhoid.^[6] By the early 20th century, state DPHs expanded to include laboratory services, vaccination programs, and regulatory oversight, reflecting advances in microbiology and epidemiology.^[6] Core responsibilities of state DPHs align with the Centers for Disease Control and Prevention's (CDC) framework of 10 Essential Public Health Services, which include assessing and monitoring population health status to identify risks; investigating health problems and hazards through surveillance and diagnostics; informing, educating, and empowering communities via campaigns on nutrition, hygiene, and immunization; and enforcing laws and regulations to control environmental and occupational hazards.^[9] Additional functions encompass mobilizing partnerships for emergency response, such as during the 1918 influenza pandemic when states coordinated antitoxin distribution, and developing policies to address chronic diseases, maternal-child health, and behavioral risks like tobacco use.^[6]^[9] These agencies also maintain public health laboratories for testing pathogens and contaminants, reporting over 50 million tests annually in some states pre-2020.^[10] Organizational structure varies by state but typically features a commissioner or secretary leading divisions for epidemiology and communicable diseases, environmental health, health promotion, vital records, and regulatory licensing, with staffing comprising about one-third nurses, one-third administrative personnel, and the rest specialists in areas like data analysis.^[10]^[11] In approximately 45% of states, the DPH operates under a larger "super-agency" encompassing social services or mental health, while others maintain centralized control over local operations or decentralize authority to county-level units for tailored responses.^[12] Funding derives primarily from state budgets (around 40-50%), federal grants like those from the CDC for specific programs, and fees for services such as inspections, enabling responses to contemporary threats including opioid overdoses, where DPHs distributed naloxone kits to over 1 million users in high-burden states by 2023.^[10]^[13]

Law and Legal Processes

Due Process Hearing

A due process hearing is a formal administrative proceeding mandated by the Fifth and Fourteenth Amendments to the U.S. Constitution, requiring government entities to provide individuals with notice and an opportunity to be heard before depriving them of life, liberty, or property.^[14] This ensures procedural fairness in adjudicative actions, such as license revocations, benefit terminations, or disciplinary proceedings, where the Mathews v. Eldridge test (1976) balances the private interest affected, the risk of erroneous deprivation under existing procedures, and the government's interest in efficiency.^[15] Hearings typically occur in administrative law contexts, conducted by impartial hearing officers or administrative law judges who evaluate evidence without deference to the agency's initial findings.^[16] The process begins with written notice to the affected party, detailing the proposed action, factual basis, legal authority, and rights to respond, often within statutory timelines like 15 days for resolution attempts in certain disputes.^[17] Parties may then present witnesses, documents, testimony, and arguments; cross-examination is generally permitted, though discovery rules vary by jurisdiction and may be limited compared to civil trials.^[18] Decisions must be based on the record, issued in writing with findings of fact and conclusions of law, typically within 45-75 days absent extensions for good cause, and are subject to judicial review under standards like substantial evidence.^[19] In specific applications, such as special education under the Individuals with Disabilities Education Act (IDEA), due process hearings resolve parent-school disagreements over identification, evaluation, placement, or services for children with disabilities, with hearings held before an impartial officer and appeals possible to state or federal courts.^[20] Similarly, in employment or licensing disputes, agencies like state education departments conduct hearings to assess terminations or certifications, emphasizing rebuttal opportunities to mitigate arbitrary decisions.^[21] Noncompliance with hearing requirements can invalidate agency actions, as courts enforce minimum protections against biased or ex parte proceedings.^[22]

Health, Medicine, and Degrees

Doctor of Public Health

The Doctor of Public Health (DrPH) is a professional doctoral degree designed to prepare individuals for advanced leadership roles in public health practice, emphasizing applied skills in policy, management, and program implementation rather than original research generation.^[23]^[24] Unlike research-oriented doctorates, the DrPH focuses on equipping practitioners to address real-world public health challenges through strategic decision-making and organizational leadership.^[25] Programs typically require completion of 42 or more credit hours, including core coursework in health policy, analytics, communication, and electives tailored to professional interests, with an expectation of finishing in four to seven years, often part-time for working professionals.^[26] The degree traces its origins to 1919, when the American Public Health Association's Committee of Sixteen on the Standardization of Public Health Training formalized the DrPH as a terminal credential for public health professionals, distinguishing it from emerging research-focused doctorates.^[27] Admission generally mandates a master's degree in public health (such as an MPH) or equivalent, along with at least three years of post-master's professional experience in public health to ensure candidates possess practical grounding for advanced study.^[28] In contrast to the PhD in public health, which prioritizes theoretical research, statistical methodology, and academic scholarship to produce new knowledge, the DrPH curriculum builds competencies in leadership, applied epidemiology, and systems-level interventions, often culminating in a practice-based dissertation or capstone project rather than a traditional dissertation.^[23]^[29] This orientation suits mid-career professionals aiming for executive positions, whereas PhD holders more commonly pursue tenure-track faculty roles or independent research.^[24] Accreditation for DrPH programs is provided by the Council on Education for Public Health (CEPH), which evaluates curricula, faculty qualifications, and outcomes against standards ensuring graduates meet professional benchmarks in areas like biostatistics, environmental health, and health services administration.^[30]^[31] CEPH accreditation, typically granted for seven years, signals program quality and eligibility for federal funding or licensure in practice settings.^[32] Graduates pursue careers in governmental agencies, nongovernmental organizations, and health systems, often as directors of health departments, policy advisors, or program evaluators, with median salaries reported around $125,750 reflecting demand for experienced leaders amid growing public health needs.^[33]^[34] Employment outcomes emphasize roles bridging research and implementation, such as leading outbreak responses or health equity initiatives, where prior experience amplifies impact.^[35]

Diploma in Public Health

The Diploma in Public Health (DPH) is a postgraduate-level qualification designed to impart foundational knowledge and practical skills in public health principles, including disease prevention, health promotion, epidemiology, and policy implementation. Programs emphasize evidence-based approaches to addressing population-level health challenges, such as infectious disease control and environmental risks, preparing graduates for roles in health administration, community health, and policy advising. Typically spanning 1 year of full-time study or up to 4 years part-time, the DPH consists of 120 credit points across core and elective modules, enabling flexible completion for working professionals.^[36]^[37] Admission to DPH programs generally requires a bachelor's degree in a relevant field, such as medicine, nursing, or social sciences, with some institutions mandating professional experience or a minimum academic performance standard equivalent to a B average. For instance, candidates must often demonstrate prior exposure to health-related work, and programs like those at the University of Otago prioritize applicants with backgrounds in clinical or community health to ensure readiness for advanced public health training. This prerequisite structure aims to build on undergraduate foundations, focusing on interdisciplinary application rather than basic sciences alone.^[37]^[38] Core curriculum components universally cover biostatistics for data analysis in health outcomes, epidemiology for studying disease patterns, and health systems management for evaluating service delivery efficiency. Electives may include environmental health, addressing factors like pollution and sanitation, or health promotion strategies rooted in behavioral science and community interventions. Practical elements, such as project-based assessments or fieldwork, reinforce causal linkages between interventions and health metrics, with programs like the University of Queensland's Graduate Diploma incorporating modules on global health challenges and policy evaluation. This structure fosters skills in designing surveillance systems and critiquing evidence from randomized trials or cohort studies, prioritizing empirical validation over theoretical models.^[39]^[40] Graduates pursue careers in governmental health departments, non-governmental organizations, or international bodies like the World Health Organization, applying DPH training to real-world scenarios such as outbreak response or vaccination campaigns. Evidence from program outcomes indicates improved competency in quantitative risk assessment, with alumni contributing to policy reforms based on longitudinal health data rather than anecdotal reports. While program specifics vary by jurisdiction—e.g., New Zealand's offerings emphasize indigenous health disparities—the DPH remains a targeted credential for mid-career advancement in evidence-driven public health practice.^[37]^[41]

Diphenhydramine

Diphenhydramine is a first-generation antihistamine with the chemical formula C₁₇H₂₁NO and IUPAC name 2-(benzhydryloxy)-N,N-dimethylethanamine.^[42] It functions primarily as an inverse agonist at histamine H1 receptors, blocking histamine-mediated effects on smooth muscle, vascular endothelium, and the central nervous system, which alleviates allergic responses and induces sedation.^[43] Additionally, it exhibits significant anticholinergic activity by antagonizing muscarinic acetylcholine receptors, contributing to its sedative, antiemetic, and antitussive properties, though this also underlies many adverse effects.^[1] The compound crosses the blood-brain barrier readily due to its lipophilicity, resulting in pronounced central nervous system depression compared to second-generation antihistamines.^[43] Medically, diphenhydramine is approved by the U.S. Food and Drug Administration for temporary relief of symptoms associated with hay fever, upper respiratory allergies, and the common cold, including sneezing, runny nose, itchy eyes, and hives.^[4] It is also indicated for motion sickness prevention, insomnia, and as an adjunct in Parkinson's disease to manage extrapyramidal symptoms and dystonias.^[1] Off-label uses include treatment of acute allergic reactions, nausea, and vertigo, with injectable forms employed in anaphylaxis or severe urticaria.^[44] Typical oral doses range from 25 to 50 mg every 4 to 6 hours for adults, not exceeding 300 mg daily, while pediatric dosing is weight-based at 1 mg/kg every 6 hours.^[45] Common adverse reactions include drowsiness, dizziness, dry mouth, blurred vision, constipation, and urinary retention, attributable to its anticholinergic blockade.^[1] These effects are more prevalent in the elderly and children, with paradoxical excitation possible in young patients.^[46] Less frequent but serious reactions encompass confusion, hallucinations, tachycardia, and orthostatic hypotension.^[47] Contraindications include narrow-angle glaucoma, prostatic hypertrophy, and hypersensitivity, with caution advised in patients with asthma, hypertension, or concomitant use of other CNS depressants like alcohol or opioids.^[1] Overdose poses substantial risks, with ingestions exceeding 1 gram potentially causing anticholinergic delirium, psychosis, seizures, coma, rhabdomyolysis, and wide-complex tachycardia due to sodium channel blockade.^[2] Fatal outcomes have been documented, often involving cardiac arrhythmias or respiratory failure, prompting FDA warnings against high-dose misuse for hallucinogenic effects.^[4] Management entails supportive care, activated charcoal, benzodiazepines for seizures, and sodium bicarbonate for cardiac toxicity.^[2] Synthesized in 1943 by George Rieveschl at the University of Cincinnati during research into antispasmodic agents, diphenhydramine was the first antihistamine approved by the FDA in 1946 for allergy treatment, marketed as Benadryl by Parke-Davis.^[48] Its widespread availability as an over-the-counter drug since the 1980s has facilitated self-medication but heightened risks of abuse and toxicity.^[48]

Science and Biology

DPH Genes

The DPH genes (DPH1 through DPH7) encode enzymes required for the biosynthesis of diphthamide, a post-translationally modified histidine residue (at position 715) uniquely present on eukaryotic elongation factor 2 (eEF2), which is essential for accurate ribosomal protein synthesis and cellular resistance to certain toxins such as diphtheria toxin.^[49] ^[50] This modification pathway is highly conserved across eukaryotes and archaea, involving a complex seven-step process that begins with the radical-mediated attachment of a 3-amino-3-carboxypropyl (ACP) group to the imidazole ring of histidine, followed by trimethylation to form diphthine, and concluding with amidation to yield diphthamide.^[51] ^[52] The initial ACP transfer step requires the DPH1–DPH4 proteins: DPH1 and DPH2 form an oxygen-sensitive heterodimeric radical S-adenosylmethionine (SAM) enzyme complex containing iron-sulfur clusters that generate the ACP radical from S-adenosylmethionine (SAM), while DPH3 acts as an electron donor to facilitate this reaction, and DPH4 provides structural support.^[51] ^[53] Subsequent steps involve DPH5, a diphthine synthase that catalyzes diphthine formation through three successive methyl transfers using SAM as the methyl donor.^[49] The final amidation of diphthine to diphthamide occurs in two phases mediated by DPH6 and DPH7, which together with eEF2 form a complex enabling the ligation of the amide group from ATP-dependent polyamine donors.^[53] ^[54] Mutations in DPH genes disrupt diphthamide synthesis, leading to diphthamide deficiency syndrome (DDS), an autosomal recessive neurodevelopmental disorder characterized by intellectual disability, developmental delay, craniofacial dysmorphism (e.g., microcephaly or macrocephaly, sparse hair), and short stature.^[55] ^[56] For instance, biallelic loss-of-function variants in DPH1 (e.g., homozygous c.1400G>A, p.Arg467Gln) cause severe DDS phenotypes including unique facial features and hypotonia, as reported in affected individuals from consanguineous families.^[57] Similarly, DPH2 and DPH5 variants compromise enzyme function, resulting in partial or complete loss of diphthamide and associated cellular hypersensitivity to translation inhibitors.^[58] Beyond DDS, DPH perturbations link to oncogenesis; for example, DPH1 and DPH3 inactivation elevates DNA replication stress and NF-κB signaling, promoting tumor cell survival, while DPH3 mutations correlate with basal cell carcinoma susceptibility.^[59] ^[60] These effects stem from diphthamide's role in stabilizing eEF2-ribosome interactions and suppressing erroneous translation, underscoring its causal importance in translational fidelity and cellular homeostasis.^[61]

1,6-Diphenyl-1,3,5-hexatriene

1,6-Diphenyl-1,3,5-hexatriene (DPH) is a linear conjugated polyene hydrocarbon with the molecular formula C₁₈H₁₆ and a molecular weight of 232.32 g/mol. The compound features two phenyl groups attached to the terminal carbons of a 1,3,5-hexatriene chain, conferring rigidity and planarity that enable its utility as a fluorescent probe.^[62] Its CAS number is 1720-32-7, and it exhibits low solubility in water due to its hydrophobic nature.^[63] DPH displays weak fluorescence in aqueous environments but exhibits strong, anisotropic emission when incorporated into hydrophobic regions such as lipid bilayers, making it sensitive to membrane microviscosity and order. Fluorescence anisotropy measurements with DPH are widely employed to assess membrane fluidity, where depolarization of emitted light correlates with rotational mobility in the acyl chain domain of phospholipids.^[64] Time-resolved fluorescence decay analysis of DPH reveals heterogeneity in membrane environments, with lifetime distributions reflecting phase transitions or compositional variations in artificial and cellular membranes.^[65] In biological applications, DPH serves as a probe for studying phospholipid packing and dynamics in cell membranes, including erythrocyte membranes where it highlights structural organization via fluorescence lifetime heterogeneity.^[66] It has been utilized to evaluate temperature-dependent changes in membrane fluidity, showing increased anisotropy (indicating higher order) at lower temperatures in model phospholipid systems.^[67] Beyond membranes, DPH binds to amyloid fibrils, potentially interfering with their detection, and acts as an alternative to Nile red for labeling lipid droplets in fluorescence microscopy.^[68]^[63] Its spectral properties, including absorption maxima influenced by solvent polarity, support its role as a standard for fluorescence quantum yield and lifetime calibrations.^[69]

References

[1]
Diphenhydramine - StatPearls - NCBI Bookshelf - NIH
Mar 27, 2025 · Adverse Effects · Drowsiness · Dizziness · Impaired coordination · Headache · Epigastric discomfort · Thickened bronchial secretions · Dry mucous ...Indications · Mechanism of Action · Administration · Adverse Effects
[2]
Diphenhydramine Toxicity - StatPearls - NCBI Bookshelf - NIH
Apr 29, 2023 · Patients with more severe toxicity may also have severe delirium, seizures, psychosis, hypotension, dystonic reactions, hallucinations, and ...
[3]
Chronic diphenhydramine abuse and withdrawal - PubMed Central
Abuse of DPH may be difficult to identify; overdose symptoms are similar to acute psychosis and often prompt hospitalization, which may precipitate ...
[4]
FDA warns about serious problems with high doses of the allergy ...
Oct 1, 2020 · Taking higher than recommended doses of the common over-the-counter (OTC) allergy medicine diphenhydramine (Benadryl) can lead to serious heart problems, ...
[5]
Long-term use of diphenhydramine - PMC - NIH
A recently published prospective cohort study reveals a higher cumulative strong anticholinergic use is associated with an increased risk for dementia.
[6]
A History of the Public Health System - NCBI - NIH
Massachusetts, Michigan, and New York City began producing and dispensing antitoxins in the 1890s. Several states established disease registries. In 1907, ...
[7]
Department of Public Health (DPH) - Mass.gov
Department of Public Health (DPH) · Contact us · Social media links · Recent news & announcements · Who we serve · Our bureaus and offices · Additional DPH links.About DPH: Resources... · Contact DPH by web form · Working at DPH
[8]
Georgia Department of Public Health
The Georgia Department of Public Health (DPH) is the lead agency in preventing disease, injury and disability; promoting health and well-being; ...Career Opportunities · Contact DPH · About DPH · Environmental Health
[9]
10 Essential Public Health Services - CDC
May 16, 2024 · Assess and monitor population health status, factors that influence health, and community needs and assets · Investigate, diagnose, and address ...
[10]
Structure and Functions of State Public Health Agencies - PMC
Most state health departments continue to focus on subpopulations such as children with special health-care needs, to support public health laboratories, and to ...
[11]
Summary of the Public Health System in the United States - NCBI - NIH
At present, the main federal unit with responsibility for public health is the United States Public Health Service in the Department of Health and Human ...
[12]
State & Local Public Health: An Overview of Regulatory Authority
Oversight: Assume ultimate responsibility for public health performance in the community by providing necessary leadership and guidance in order to support the ...
[13]
https://kff.org/other-health/health-policy-101-u-s-public-health/
[14]
Procedural Due Process Civil :: Fourteenth Amendment - Justia Law
Due process requires that the procedures by which laws are applied must be evenhanded, so that individuals are not subjected to the arbitrary exercise of ...
[15]
Procedural Due Process - US Constitution Annotated - Justia Law
Due process must be held to guarantee not particular forms of procedures, but the very substance of individual rights to life, liberty, and property.
[16]
Procedural due process rights (administrative state) - Ballotpedia
Procedural due process specifically concerns the legal procedures administrative agencies are required to follow during rulemaking and adjudication proceedings.Foundations of procedural due... · U.S. Constitution · Applied procedural due...
[17]
34 CFR 300.511 -- Impartial due process hearing. - eCFR
The party requesting the due process hearing may not raise issues at the due process hearing that were not raised in the due process complaint filed under ...<|separator|>
[18]
The Due Process Hearing, in Detail - Center for Parent Information ...
During a due process hearing, each party has the opportunity to present their views in a formal legal setting, using witnesses, testimony, documents, and legal ...How due process systems are... · How the hearing officer decides · TimelinesMissing: contexts | Show results with:contexts
[19]
Due Process Hearings - DGS.ca.gov
A due process hearing must be conducted, and a decision issued within 45 days of receipt of the due process notice unless an extension is granted for good cause ...
[20]
Due Process Hearing | New York State Education Department
A due process hearing (also known as an impartial hearing) is a formal process to resolve disagreements between a parent of a student with a disability and ...
[21]
Due Process | Arizona Department of Education
Due Process is the most formal of the dispute resolution options and may be used to resolve any matter relating to the identification, evaluation, or placement ...
[22]
Procedural Due Process: What individual interests are protected ...
The government must provide you with an opportunity to rebut their charges against you in a meaningful way and at a meaningful time (the "hearing requirement").
[23]
DrPH vs. PhD: What's the Difference? - Tulane University
Dec 1, 2022 · DrPH programs sometimes require three years of experience or a master's degree such as a Master of Public Health (MPH). PhD programs are less ...
[24]
DrPH vs. PhD - National Association for Doctors of Public Health
A PhD is designed for a career in research, most often in academia (ie being a professor), while a DrPH is designed for practitioners who seek to work in ...
[25]
Doctor of Public Health | DrPH | Johns Hopkins
The DrPH program is built around foundational competencies that focus on leadership, analytical skills, communication, policy, management, and program design ...Missing: definition | Show results with:definition
[26]
Doctor of Public Health (DrPH)
A total of 42 credit hours is required for the DrPH, including 12 credits of electives. Students are expected to complete the degree within four to seven years, ...Missing: definition | Show results with:definition
[27]
A REVIEW OF THE STATUS OF THE DOCTOR OF PUBLIC ... - NIH
The DrPH degree was first established in 1919 by the American Public Health Association Committee of Sixteen on the Standardization of Public Health Training.<|separator|>
[28]
Doctor of Public Health (DrPH)
A master's-level degree in public health (MPH or MSPH). · At least three years of experience in the public health area after having completed a master's degree.
[29]
https://research.com/advice/drph-vs-phd
[30]
DrPH Doctor of Public Health Program | Penn State
The DrPH degree program is accredited by the Council on Education for Public Health (CEPH). To request a copy of our accreditation self-study document and ...
[31]
DrPH Online, CEPH Accredited Doctors of Public Health Online
The online DrPH is a part-time, CEPH-accredited program for professionals with an MPH, designed to equip leaders in health equity, with flexible, asynchronous ...
[32]
Accreditation - Doctor of Public Health
The MPH and DrPH programs were accredited by the Council on Education for Public Health (CEPH) in October 2017 for the maximum period of seven years.
[33]
Public Health Salaries and Jobs
Public Health Employment Outcomes. Mailman School graduates pursue their ... Doctor of Public Health. $125,750. $112,500. Executive MPH. $245,500. $217,500.Public Health Employment... · Salaries · Salary By Industry: School...
[34]
What Can You Do With a Doctor of Public Health Degree?
A high-quality DrPH program can help prepare you to work as a leader or administrator in a variety of practice-based settings within the public, private, or ...
[35]
What is a DrPH? The Degree Bridging Research and Real-World ...
Sep 18, 2025 · Although the DrPH and PhD are often conflated, they serve distinct purposes in public health. A PhD in public health is designed to generate ...
[36]
Postgraduate Diploma in Public Health | UC - University of Canterbury
Jul 31, 2025 · ThePGDipPH is a 120-point qualification that can be completed in 1 year full-time, or up to 4 years part-time. Starting in February each year, ...
[37]
Postgraduate Diploma in Public Health (DPH) - University of Otago
The Postgraduate Diploma in Public Health (DPH) is a broad-based and practical qualification consisting of four core papers and four further papers for ...
[38]
Diploma In Public Health (DPH) - Research Council of Health, London
Diploma in Public Health (DPH) is designed to develop public health skills at the postgraduate level. Candidates are required to hold a degree.
[39]
Graduate Diploma in Public Health - Study at UQ
What you'll study · Introduction to Environmental Health · Health Promotion in Public Health · Introduction to Epidemiology · Health Systems.
[40]
Postgraduate Diploma in Public Health – PGDipPH
The Postgraduate Diploma in Public Health will give you leading-edge expertise in many different subjects, such as: epidemiology and biostatistics ...
[41]
Graduate Diploma in Public Health | Western Sydney University
The Graduate Diploma in Public Health is designed for health professionals who wish to extend their practical and research skills for public health ...
[42]
Diphenhydramine | C17H21NO | CID 3100 - PubChem - NIH
Diphenhydramine | C17H21NO | CID 3100 - structure, chemical names, physical and chemical ... 2.1.1 IUPAC Name. 2-benzhydryloxy-N,N-dimethylethanamine.
[43]
Diphenhydramine: Uses, Interactions, Mechanism of Action
Diphenhydramine is a H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, ...
[44]
[PDF] Diphenhydramine Hydrochloride Injection - accessdata.fda.gov
Jan 4, 2013 · INDICATIONS AND USAGE Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature ...
[45]
Benadryl, Nytol (diphenhydramine) dosing, indications, interactions ...
Pharmacology. Mechanism of Action. Histamine H1-receptor antagonist of effector cells in respiratory tract, blood vessels, and GI smooth muscle. Moderate to ...
[46]
Diphenhydramine: MedlinePlus Drug Information
Aug 15, 2025 · It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. How should this medicine be used?Missing: pharmacology | Show results with:pharmacology
[47]
Diphenhydramine Side Effects: Common, Severe, Long Term
Oct 3, 2025 · Side effects include: Sedation, sleepiness, dizziness, disturbed coordination, epigastric distress, thickening of bronchial secretions.
[48]
Diphenhydramine: A Review of Its Clinical Applications and ...
QT interval prolongation can also occur especially with high doses of diphenhydramine, which can result in lethal ventricular arrhythmias including torsade de ...
[49]
THE BIOSYNTHESIS AND BIOLOGICAL FUNCTION OF ... - NIH
Molecular function of the DPH genes. The first step of diphthamide biosynthesis is the transfer of the ACP group from SAM to the C2 position of the imidazole ...
[50]
Gene ResultDPH1 diphthamide biosynthesis 1 [ (human)] - NCBI
Aug 19, 2025 · The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2).
[51]
Decoding the biosynthesis and function of diphthamide, an ...
This generates the ACP intermediate and requires Dph1-Dph4, where the iron-sulfur cluster proteins Dph1/Dph2 are directly involved in ACP radical generation ...
[52]
Diphthamide – a conserved modification of eEF2 with clinical ...
Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndrome (DDS). Finally, new ...
[53]
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires ...
In Saccharomyces cerevisiae, the initial steps of diphthamide biosynthesis are well characterized and require the DPH1-DPH5 genes. ... DPH genes (Figure 2A). Such ...
[54]
Diphthamide synthesis is linked to the eEF2‐client chaperone ...
Jan 17, 2025 · It is physically connected to eEF2 (Dph-substrate), Dph1 (1st step of diphthamide synthesis), Dph5 (2nd step), Dph7 (3rd step), and Dph6 (4th ...<|separator|>
[55]
Diphthamide-deficiency syndrome: a novel human developmental ...
Jun 23, 2020 · In yeast, diphthamide biosynthesis was elucidated to proceed in four consecutive steps requiring a minimum of seven gene products (Dph1–Dph7) as ...
[56]
DPH1 and DPH2 variants that confer susceptibility to diphthamide ...
Sep 22, 2023 · Summary: Diphthamide deficiency syndrome is caused by mutations in DPH genes. Analyses in human cell and yeast models identified functionally ...
[57]
DPH1 and DPH2 variants that confer susceptibility to diphthamide ...
Our study has identified functionally compromised alleles of DPH1 and DPH2 genes that likely cause diphthamide deficiency syndrome.
[58]
Expanding the Phenotypic Spectrum Associated with DPH5-Related ...
Loss-of-function (LoF) mutations in genes involved in diphthamide biosynthesis, such as DPH1, DPH2, and DPH5, result in developmental delay (DD), intellectual ...
[59]
Loss of Diphthamide Increases DNA Replication Stress in ...
Sep 6, 2024 · It is well-established that deleting either of the seven diphthamide biosynthesis genes (DPH1–7) will result in the loss of the diphthamide ...
[60]
Integrative analysis of the role of the DPH gene family in ... - NIH
Mutations in the DPH3 gene have been associated with basal cell carcinoma (19,20). And fusions of the DPH7 and PTP4A3 genes may be associated with tumor ...
[61]
Diphthamide promotes TOR signaling by increasing the translation ...
Sep 10, 2021 · Diphthamide biosynthesis requires four steps involving at least seven proteins, with the first step being chemically challenging and requiring a ...<|separator|>
[62]
https://www.sigmaaldrich.com/US/en/product/aldrich/d208000
[63]
1,6-DIPHENYL-1,3,5-HEXATRIENE | 1720-32-7 - ChemicalBook
Jan 27, 2025 · Uses. 1,6-Diphenyl-1,3,5-hexatriene is an alternative to Nile red for fluorescent detection of lipid droplets. Uses. 1,6-Diphenyl-1,3,5- ...
[64]
1,6 Diphenyl 1,3,5 Hexatriene - an overview | ScienceDirect Topics
1,6-Diphenyl-1,3,5-hexatriene (DPH) is a linear molecule with two phenyl groups at the extremes of its linear hydrocarbon chain. It is barely soluble in aqueous ...
[65]
Fluorescence lifetime distributions of 1,6-diphenyl-1,3,5-hexatriene ...
Synthesis and fluorescence properties in artificial membranes. Chemistry and Physics of Lipids 1988, 49 (3) , 185-195. https://doi.org/10.1016/0009-3084(88) ...
[66]
Erythrocyte membrane heterogeneity studied using 1,6-diphenyl-1,3 ...
The fluorescence decay of 1,6-diphenyl-1,3,5-hexatriene has been used to characterize the structural organization of erythrocyte membranes.Missing: spectroscopy | Show results with:spectroscopy
[67]
Temperature dependence of 1,6-diphenyl-1,3,5-hexatriene ...
Temperature dependence of 1,6-diphenyl-1,3,5-hexatriene fluorescence in phospholipid artificial membranes ... Time-Resolved Fluorescence Spectroscopy Using ...<|separator|>
[68]
The Fluorescent Dye 1,6 Diphenyl 1,3,5 Hexatriene Binds to ... - NIH
The fluorescent dye 1,6-diphenyl-1,3,5-hexatriene (DPH) is widely used as a probe of membrane order. We show that DPH also interacts with amyloid fibrils ...
[69]
1,6-Diphenyl-1,3,5-hexatriene as a fluorescence standard
DPH is suitable for development as a fluorescent standard for both yield and lifetime measurements.Missing: spectroscopy | Show results with:spectroscopy