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Damage control surgery

Damage control surgery (DCS) is a staged surgical strategy employed in critically injured or hemodynamically unstable patients, particularly those with severe abdominal trauma, to prioritize rapid control of life-threatening hemorrhage and contamination over immediate definitive anatomical repair.^[1] This approach involves an abbreviated initial laparotomy to achieve hemostasis through techniques such as packing and ligation, followed by temporary abdominal closure, allowing for transfer to the intensive care unit (ICU) for resuscitation to normalize physiology before a subsequent reoperation for comprehensive reconstruction.^[2] By addressing the lethal triad of hypothermia, acidosis, and coagulopathy—metabolic derangements that exacerbate mortality in exsanguinating patients—DCS aims to interrupt the vicious cycle of physiologic collapse and improve survival rates, which can reach up to 77% in select high-risk cases compared to 11% with traditional definitive surgery.^[3]^[1] The concept of DCS originated from early 20th-century techniques like hepatic packing, revived in the 1970s for trauma management, but was formally defined in 1993 by Rotondo and colleagues in a landmark study of 46 patients with penetrating abdominal injuries requiring massive transfusions.^[4] Their work demonstrated that abbreviating surgery to under 90 minutes and deferring repairs reduced operative time and mortality from 89% to 23% in patients with profound shock.^[2] Building on prior observations of the lethal triad by Kashuk et al. in 1982 and abbreviated laparotomy by Burch in 1992, DCS evolved as a paradigm shift from exhaustive single-operation repairs to a multidisciplinary sequence integrating surgery with damage control resuscitation (DCR).^[2]^[3] Core principles of DCS emphasize patient selection based on indicators like pH below 7.2, core temperature under 35°C, or transfusion exceeding 10 units of blood products, with the procedure unfolding in three phases: (1) intraoperative control of bleeding and contamination; (2) ICU-based correction of the lethal triad through warming, balanced transfusion (e.g., 1:1:1 ratio of red blood cells, plasma, and platelets), and permissive hypotension; and (3) delayed definitive surgery within 24–72 hours once metabolic stability is restored.^[2]^[3] Over the past three decades, DCS has expanded beyond trauma to applications in emergency general surgery, such as mesenteric ischemia or sepsis, and has been refined with DCR to enhance outcomes, including higher 30-day survival and reduced complications like abdominal compartment syndrome.^[4]^[2] Despite its benefits, challenges persist, including risks of infection from open abdomens and the need for timely fascial closure to avoid long-term ventral hernias.^[3]

Overview and Principles

Definition

Damage control surgery (DCS) represents a paradigm shift in the management of severely injured patients, emphasizing abbreviated surgical interventions over comprehensive anatomical repair. It focuses on rapidly controlling hemorrhage and mitigating contamination to permit physiological resuscitation and stabilization before proceeding to definitive reconstruction. This approach is designed for patients in extremis, where prolonged operative times could worsen outcomes by exacerbating metabolic derangements.^[5] In distinction from traditional surgical practices, which prioritize immediate and complete correction of injuries to restore anatomy, DCS deliberately truncates the initial operation to prioritize survival. By limiting surgical exposure and duration, it avoids further physiological insult in hemodynamically unstable individuals, allowing transfer to an intensive care setting for targeted resuscitation. This strategy has been shown to improve survival rates in exsanguinating trauma by addressing life-threatening conditions first.^[1] The core of DCS is structured as a three-phase process: the first phase involves an abbreviated laparotomy to achieve hemorrhage control, temporary containment of visceral injuries, and provisional closure; the second phase entails aggressive resuscitation to normalize physiology; and the third phase consists of return to the operating room for definitive repair once the patient is stabilized.^[5] This methodology is intrinsically linked to countering the "lethal triad" of hypothermia, acidosis, and coagulopathy—a vicious cycle that significantly contributes to mortality in major trauma by impairing hemostasis and organ function. Recent developments have expanded this to the "lethal diamond" by including hypocalcemia as an additional factor that worsens coagulopathy and outcomes in severely injured patients.^[6] DCS interrupts this cycle by minimizing heat loss and acid production during surgery and facilitating correction through permissive hypotension and balanced transfusion strategies in the interim phase.

Core Principles

Damage control surgery (DCS) is guided by the imperative to mitigate the lethal triad of hypothermia, acidosis, and coagulopathy, a synergistic metabolic derangement that exacerbates mortality in severely injured patients by creating a self-perpetuating cycle of instability.^[7] Hypothermia, typically induced by environmental exposure, hemorrhagic shock, and administration of cold intravenous fluids or blood products, impairs platelet function and coagulation enzyme activity, with temperatures below 35°C leading to significant clotting dysfunction and mortality rates approaching 100% when below 32°C.^[3] Acidosis arises primarily from tissue hypoperfusion and anaerobic metabolism, resulting in lactic acid accumulation that depresses myocardial contractility, further worsening hypoperfusion and bleeding while inhibiting coagulation factors.^[3] Coagulopathy manifests through both consumptive mechanisms, such as widespread activation of the coagulation system from tissue injury and endothelial damage, and dilutional effects from large-volume crystalloid resuscitation, which depletes clotting factors and platelets, thereby amplifying hemorrhage.^[2] A foundational principle of DCS is physiological prioritization, which emphasizes abbreviating surgical intervention to rapidly control bleeding and contamination while deferring complex reconstructions until metabolic homeostasis is restored, thereby avoiding exacerbation of the lethal triad during prolonged operations.^[1] This approach limits initial surgery to under 90 minutes to minimize additional physiological insult from operative stress and heat loss.^[2] DCS integrates seamlessly with damage control resuscitation (DCR), a complementary strategy that employs permissive hypotension and a balanced administration of blood products—such as plasma, platelets, and red blood cells in near-equimolar ratios—to counteract dilutional coagulopathy, limit crystalloid-induced acidosis, and support early correction of the lethal triad components.^[8] The overarching goal of these principles is to interrupt the cycle of instability by halting ongoing tissue injury and facilitating intensive resuscitation in a controlled environment, ultimately stabilizing the patient to permit safe definitive surgical reconstruction once physiology normalizes.^[1]

Indications and Patient Selection

Trauma-Specific Criteria

Damage control surgery (DCS) in trauma is indicated for specific injury patterns that pose a high risk of exsanguination or physiological decompensation, including penetrating abdominal trauma, multiple injuries with an Injury Severity Score (ISS) greater than 25, and junctional or non-compressible hemorrhage.^[9] Penetrating abdominal injuries, particularly those involving major vascular structures or multiple viscera, often necessitate DCS due to the potential for rapid blood loss exceeding 10 units of packed red blood cells.^[10] Similarly, polytrauma with high ISS reflects widespread tissue damage that overwhelms standard repair capabilities, while junctional hemorrhage—such as in the axilla, groin, or neck—requires abbreviated interventions to achieve temporary hemostasis before full resuscitation.^[11] Physiological thresholds serve as critical benchmarks for DCS activation, signaling the onset of the lethal triad of hypothermia, acidosis, and coagulopathy.^[12] Key indicators include persistent hypotension with systolic blood pressure (SBP) below 90 mmHg despite resuscitation, core body temperature below 35°C, arterial pH less than 7.2 indicating severe acidosis, and coagulopathy evidenced by an International Normalized Ratio (INR) greater than 1.5 or ongoing bleeding refractory to transfusion.^[9] These derangements, often compounded by massive transfusion needs, predict poor outcomes with definitive surgery and justify a shift to DCS to prioritize physiological stabilization over anatomical correction.^[10] Timing of DCS is primarily intraoperative, triggered by recognition of instability during initial surgical exploration, such as deteriorating vital signs or failure to achieve hemostasis after basic control measures.^[9] Preoperative assessment may suggest DCS in profoundly unstable patients, but definitive decision-making occurs in the operating room to avoid delays in high-risk cases.^[12] Stable trauma patients, those maintaining SBP above 90 mmHg, normothermia, normal pH, and absence of coagulopathy, are generally excluded from DCS and directed toward immediate definitive repair to minimize operative time and complications.^[10] This selection ensures DCS is reserved for those at imminent risk of irreversible shock, optimizing survival in severe trauma.^[9]

Non-Trauma Applications

Damage control surgery (DCS) principles, which emphasize abbreviated initial interventions to stabilize physiology before definitive repair, have been adapted to non-traumatic surgical emergencies where patients exhibit profound instability. In emergency general surgery, DCS is applied to conditions such as perforated viscera causing generalized peritonitis, acute mesenteric ischemia, and severe pancreatitis with hemodynamic compromise. For perforated viscera, such as in diverticulitis or peptic ulcer perforation, the approach involves rapid source control through resection or diversion without immediate anastomosis, followed by temporary abdominal closure to allow resuscitation.^[13] In acute mesenteric ischemia, DCS facilitates resection of non-viable bowel with temporary closure, enabling reassessment of marginal bowel viability during a second-look procedure within 24-48 hours, particularly in patients with poor resuscitation response or extensive involvement.^[14] For severe pancreatitis, especially necrotizing cases with vascular injury or instability, DCS includes debridement, packing, and drainage to control hemorrhage and infection, deferring complex reconstructions like pancreaticoduodenectomy.^[15] Patient selection criteria for DCS in non-trauma settings mirror those in trauma but focus on sepsis-induced or hypovolemic states without injury mechanisms, such as persistent acidosis (pH <7.2), hypothermia (<35°C), coagulopathy, or lactate >5 mmol/L indicating lethal triad equivalents. These thresholds guide abbreviated laparotomy when conventional repair risks further deterioration, prioritizing temporary measures like packing or stoma creation over anastomosis in septic shock from peritonitis or ischemia.^[13] This adaptation underscores the core principle of physiologic restoration over anatomic perfection, applied judiciously in hemodynamically unstable patients unresponsive to initial resuscitation.^[16] Post-2020 evidence supports DCS extension to vascular and obstetric emergencies. In ruptured abdominal aortic aneurysms, damage control strategies during open repair—such as hemostatic packing and temporary vacuum-assisted closure—followed by planned second-look operations within 1-3 days, mitigate abdominal compartment syndrome and improve outcomes in high-volume centers, with 30-day mortality rates of 15-50% depending on physiologic burden.^[17] For obstetric hemorrhage, such as uterine rupture or placenta accreta spectrum disorders, abdominopelvic packing achieves hemostasis in 62-90% of refractory cases, with temporary closure allowing intensive care stabilization before repacking removal within 24-48 hours, reducing maternal mortality in multidisciplinary settings.^[18] Despite these applications, DCS in non-trauma remains less standardized than in trauma, with ongoing debate over efficacy due to limited high-quality evidence. A 2022 meta-analysis of 21 studies (1,573 patients) found no significant mortality difference between DCS and conventional surgery (risk difference 0.09, 95% CI -0.06 to 0.24), though observed mortality was lower than expected (risk difference -0.18, 95% CI -0.29 to -0.06), attributed to selection bias in retrospective data without randomized trials. High heterogeneity (I² 89%) and risks like infection or prolonged open abdomen highlight the need for prospective studies to refine indications.^[19]

Surgical Technique

Initial Abbreviated Laparotomy

The initial abbreviated laparotomy represents the first phase of damage control surgery, aimed at rapidly addressing life-threatening hemorrhage and contamination in critically injured patients while minimizing operative time and physiological insult. This approach is particularly indicated for patients with severe abdominal trauma who exhibit signs of physiological exhaustion, such as those requiring massive transfusion or showing early coagulopathy. The procedure prioritizes source control over anatomical restoration, allowing for subsequent resuscitation in the intensive care unit before definitive repair.^[20] The operation begins with a midline laparotomy incision, often extended superiorly if needed for thoracic access, to provide broad exposure of the abdominal cavity. Upon entry, surgeons perform a systematic four-quadrant exploration, starting with rapid evacuation of blood, clots, and debris to identify sources of bleeding and contamination. Hemorrhage is controlled primarily through packing rather than meticulous vessel suturing or reconstruction, which is avoided to prevent prolongation of the procedure; identifiable major vessels may be ligated or shunted temporarily if feasible, but diffuse oozing from coagulopathy is managed with tamponade. Contamination from hollow viscus injuries is addressed by quick measures such as stapling or ligating bowel ends, without attempting resection, anastomosis, or extensive dissection that could exacerbate heat loss or acidosis.^[20] To achieve source control efficiently, the procedure is limited to under 90 minutes, focusing exclusively on hemorrhage and contamination mitigation while deferring non-vital repairs. Packing techniques involve placing multiple laparotomy pads in each of the four abdominal quadrants, applied with bimanual compression to tamponade venous and parenchymal bleeding, particularly in the liver or pelvis; pads are positioned strategically, such as above and below the liver for hepatic injuries, and secured to avoid slippage.^[4] The decision to abbreviate the laparotomy and proceed to closure is guided by intraoperative indicators of deterioration, including a falling pH below 7.2, rising serum lactate above 5 mmol/L, core temperature below 35°C, or transfusion of more than 10 units of blood products, signaling the lethal triad of hypothermia, acidosis, and coagulopathy.^[20]^[21]

Temporary Abdominal Closure

Temporary abdominal closure (TAC) is a critical component of damage control surgery, employed when primary fascial closure is not feasible due to visceral edema, ongoing resuscitation needs, or risk of intra-abdominal hypertension following the initial abbreviated laparotomy. This approach involves provisional coverage of the open abdominal wound to contain viscera, facilitate fluid drainage, and permit re-exploration while the patient stabilizes in the intensive care unit. TAC techniques prioritize ease of application, protection against evisceration, and minimization of contamination, enabling interruption of the lethal triad of hypothermia, acidosis, and coagulopathy through permissive resuscitation.^[22] Common methods for TAC include vacuum-assisted closure (VAC) systems, silo bags, and the Bogotá bag. VAC devices, such as the ABThera system, apply negative pressure over a fenestrated foam interface covered by an occlusive drape, promoting fluid evacuation, reducing edema, and approximating the fascia over time; systematic reviews indicate VAC achieves fascial closure rates of approximately 60% with lower associated mortality compared to other techniques.^[23]^[22] Silo bags, typically sterile plastic sheeting draped over the viscera and secured to the fascial edges, provide simple containment without active drainage, while the Bogotá bag—a sterile 3-liter intravenous fluid bag sutured to the skin or fascia—offers a low-cost, readily available alternative for similar purposes in resource-limited settings.^[22] These methods are selected based on institutional resources and patient physiology, with VAC preferred for its efficacy in trauma scenarios due to enhanced bacterial clearance and fascial traction.^[24] The primary rationale for TAC is to prevent abdominal compartment syndrome (ACS) by allowing abdominal domain expansion during resuscitation, thereby avoiding sustained intra-abdominal pressures exceeding 20 mmHg that could compromise organ perfusion. This is achieved through routine monitoring of intra-abdominal pressure (IAP) via bladder catheterization, with thresholds guiding decompression if needed; additionally, TAC facilitates diaphragmatic excursion to support pulmonary compliance and ventilation, mitigating risks of acute respiratory distress syndrome.^[22] By maintaining an open abdomen, TAC buys time for physiological correction without the immediate need for definitive repair, reducing evisceration and external contamination while enabling staged re-exploration for washout and assessment.^[23] TAC is typically applied at the conclusion of the initial damage control laparotomy, once hemorrhage and contamination are controlled, with the wound dressed and secured prior to transport to the ICU. Daily clinical assessments, including IAP measurements and evaluation of edema resolution, determine readiness for take-back surgeries, ideally within 24-72 hours for relaparotomy and progressive fascial closure attempts over subsequent days to achieve primary closure within 7-10 days when possible.^[22] Prolonged open abdomen beyond 7–10 days increases morbidity, though techniques like VAC can facilitate management with appropriate monitoring.^[23]^[25] While effective, TAC carries risks including infection from prolonged exposure and enteric fistula formation due to adhesions between viscera and closure materials, with reported fistula rates up to 13% in some series; other complications encompass ventral hernias if delayed closure fails and higher fungal infection incidence in open wounds.^[22]^[26] These risks underscore the need for meticulous technique and vigilant surveillance, with full details on morbidity addressed in outcomes analyses.

Definitive Reconstruction

Definitive reconstruction constitutes the final surgical phase in damage control surgery, focusing on comprehensive anatomical restoration after the patient has achieved physiological stability through intensive care resuscitation. This phase aims to address all injuries definitively while minimizing secondary complications such as infection or organ failure, transitioning from temporary measures to permanent repairs.^[2] The timing for definitive reconstruction is typically 24 to 72 hours following the initial abbreviated laparotomy, allowing sufficient interval for correction of metabolic derangements. This window aligns with the completion of damage control resuscitation, where endpoints such as normalized lactate levels and hemodynamic stability are achieved. Delays beyond 72 hours may increase risks of abdominal compartment syndrome or fistula formation, though earlier intervention within 24 hours is ideal when possible to optimize fascial closure rates.^[5]^[2] Transition to this phase requires normalization of key physiological parameters, including a pH greater than 7.2, core temperature of at least 37°C, and resolution of coagulopathy evidenced by INR less than 1.2, fibrinogen levels above 100 mg/dL, and platelet count exceeding 100,000/mm³. These criteria ensure the patient can tolerate prolonged operative times without decompensation. The decision is multidisciplinary, involving trauma surgeons, intensivists, and anesthesiologists to assess overall readiness and coordinate care.^[27]^[5] During definitive reconstruction, procedures include systematic removal of perihepatic or peripancreatic packs to control ongoing hemorrhage, followed by thorough irrigation and exploration of the abdominal cavity. Visceral injuries are repaired, such as anastomosis of bowel segments or resection of devitalized tissue, while vascular structures undergo reconstruction via primary repair, patch angioplasty, or interposition grafting as needed. Definitive fascial closure is attempted if intra-abdominal pressures remain below 12 mmHg and no ongoing contamination persists, though vacuum-assisted closure devices may be used if primary closure risks compartment syndrome. In cases of persistent instability, a staged approach permits multiple re-explorations, limiting each to under 90 minutes to avoid re-inducing the lethal triad.^[27]^[2]

Resuscitation and Supportive Care

Damage Control Resuscitation Strategies

Damage control resuscitation (DCR) represents an integrated approach to managing hemorrhagic shock and the lethal triad of hypothermia, acidosis, and coagulopathy in trauma patients undergoing damage control surgery, emphasizing early hemostatic support to stabilize physiology before definitive repair.^[28] A cornerstone of DCR is permissive hypotension, which involves maintaining systolic blood pressure (SBP) at 80-90 mmHg in patients without traumatic brain injury until definitive hemostasis is achieved, thereby avoiding disruption of formed clots and reducing further bleeding while preserving vital organ perfusion.^[29] This strategy has been associated with decreased transfusion requirements and lower rates of severe coagulopathy in hemorrhagic shock.^[30] Transfusion strategies in DCR prioritize balanced resuscitation to mimic whole blood and mitigate dilutional coagulopathy, typically employing a 1:1:1 ratio of packed red blood cells (PRBCs), fresh frozen plasma, and platelets. Recent guidelines increasingly endorse whole blood as the optimal initial resuscitative fluid to better mimic physiological coagulation and improve outcomes.^[31] This ratio improves achievement of hemostasis (86.1% vs. 78.1% with 1:1:2 ratios) and reduces exsanguination deaths within 24 hours (9.2% vs. 14.6%).^[32] Massive transfusion protocols (MTPs) are activated based on thresholds such as anticipated need exceeding 4 units of PRBCs in 1 hour or more than 2 units in the emergency department, facilitating rapid delivery of blood products. Within MTPs, tranexamic acid (TXA) is administered within 3 hours of injury to inhibit fibrinolysis, reducing all-cause mortality (relative risk 0.91) and death due to bleeding (relative risk 0.85) in bleeding trauma patients.^[33] To prevent exacerbation of acidosis, hypothermia, and coagulopathy, crystalloid administration is strictly limited, typically to less than 2 liters during initial resuscitation, with early transition to blood products as the primary volume expander.^[34] Excessive crystalloids (>2 liters) have been linked to increased mortality in hemodynamically unstable trauma patients.^[35]

Postoperative ICU Management

Following damage control surgery, patients are transferred to the intensive care unit (ICU) for aggressive physiological optimization to address the lethal triad of hypothermia, acidosis, and coagulopathy before planned definitive reconstruction.^[36] This phase emphasizes rapid correction of metabolic derangements and organ support to improve tissue perfusion and prevent secondary complications.^[37] Monitoring in the ICU involves continuous invasive hemodynamic assessment using arterial lines for blood pressure and central venous catheters for central venous pressure and oxygen saturation to guide fluid and vasopressor therapy, targeting a mean arterial pressure above 65 mmHg once initial permissive hypotension resolves.^[38] Serial laboratory evaluations, including lactate levels (aiming for clearance below 2 mmol/L) and base deficit (targeting normalization to greater than -2 mEq/L), provide markers of ongoing tissue hypoperfusion and resuscitation adequacy.^[39] Intra-abdominal pressure is measured intermittently via bladder catheter to detect intra-abdominal hypertension (≥12 mmHg) or abdominal compartment syndrome (≥20 mmHg with organ dysfunction), prompting decompression if necessary.^[40] Key interventions focus on reversing physiological insults. Active rewarming employs forced-air devices, warmed intravenous fluids, and convective warming blankets to achieve normothermia (>36°C), as persistent hypothermia below 34°C exacerbates coagulopathy and mortality.^[41] Acidosis is primarily corrected through optimized perfusion with balanced resuscitation; although the use of sodium bicarbonate remains controversial and is not routinely recommended, it may be considered in select cases if pH falls below 7.2 despite these measures.^[42]^[31] Mechanical ventilation uses a lung-protective strategy with low tidal volumes (6 mL/kg ideal body weight) and plateau pressures below 30 cmH₂O to prevent ventilator-induced lung injury and acute respiratory distress syndrome.^[43] Nutritional support initiates early enteral feeding within 24-48 hours if hemodynamically stable and without contraindications such as high-output fistulas, to preserve gut integrity and reduce infectious risks, starting at low rates (10-20 mL/hour) and advancing as tolerated.^[44] Prophylaxis against deep vein thrombosis employs low-molecular-weight heparin (e.g., enoxaparin 40 mg subcutaneously daily) once bleeding risk subsides, combined with intermittent pneumatic compression devices in high-risk trauma patients.^[45] Stress ulcer prevention uses proton pump inhibitors (e.g., pantoprazole 40 mg intravenously daily) in mechanically ventilated patients to reduce gastrointestinal bleeding incidence.^[46] Weaning from the open abdomen occurs progressively once physiological stability is achieved (typically 24-72 hours postoperatively), involving serial returns to the operating room for fascial re-approximation using techniques such as progressive closure with absorbable mesh or negative pressure wound therapy to facilitate edge approximation without excessive tension.^[47] This staged approach minimizes fistula formation and hernia risk, with definitive closure prioritized when lactate normalizes and intra-abdominal pressure remains below 12 mmHg.^[48]

History and Development

Origins in Military Medicine

The concept of damage control surgery traces its roots to early 20th-century military medicine, where surgeons sought effective methods to manage severe hepatic trauma under austere conditions. In 1908, James Hogarth Pringle, a British surgeon, first described perihepatic packing as a technique to arrest massive bleeding from liver injuries, emphasizing its role in temporarily controlling hemorrhage when direct repair was infeasible. Pringle reported successful outcomes in eight cases of traumatic liver wounds, noting that packing provided essential time for patient stabilization before further intervention, laying a foundational principle for abbreviated surgical strategies in combat settings. During World War II, military surgeons frequently employed packing for liver injuries encountered in battlefield trauma, but the approach was largely abandoned postwar due to high rates of complications, including recurrent hemorrhage upon pack removal and intra-abdominal abscesses. This period highlighted the challenges of managing coagulopathy and contamination in resource-scarce environments, where definitive repairs often exceeded available capabilities. In the Korean War, similar conservative techniques were used sparingly for hepatic wounds, with mortality from liver trauma decreasing to 14% through improved evacuation chains, though packing remained controversial owing to infection risks.^[4]^[49] The Vietnam War marked a pivotal advancement in these practices, as forward surgical units adopted abbreviated laparotomies to rapidly address life-threatening abdominal injuries. Surgeons prioritized hemorrhage control and gross contamination management—often via packing or temporary shunts—before evacuating patients to higher-level facilities, reducing average evacuation times to 2.8 hours and contributing to a liver injury mortality rate of just 9%. This era underscored the influence of combat zone constraints, including limited personnel, blood supplies, and operating time, which necessitated staging procedures to preserve physiologic reserve amid ongoing threats.^[4]^[50] These military experiences culminated in the formalization of damage control principles in the 1980s, as surgeons like H. Harlan Stone integrated abbreviated laparotomy with planned reoperation into structured protocols, directly informed by wartime lessons on resource-driven triage and stabilization.^[4]

Evolution in Civilian and Modern Practice

The concept of damage control surgery (DCS) transitioned from military applications to civilian trauma care in the late 20th century, with early adoption driven by recognition of the need for abbreviated operations in exsanguinating patients. In 1983, Stone et al. introduced the strategy of abbreviated laparotomy with intra-abdominal packing to manage intraoperative coagulopathy in civilian trauma patients, reporting improved survival in a cohort of 17 cases by prioritizing hemorrhage control over definitive repair. This approach gained traction in the 1990s, particularly through Rotondo et al.'s 1993 seminal paper, which formalized "damage control" as a staged procedure for penetrating abdominal injuries, demonstrating a survival rate increase from 11% to 77% in severely injured patients at a US level I trauma center.^[1] These works marked the popularization of DCS in non-military settings, emphasizing rapid physiological stabilization to mitigate the lethal triad of acidosis, hypothermia, and coagulopathy. In the 2000s, civilian DCS evolved through integration with damage control resuscitation (DCR), heavily influenced by military experiences from the Iraq and Afghanistan conflicts, where protocols emphasized balanced transfusion and minimized crystalloid administration to prevent dilutional coagulopathy.^[51] US civilian centers adopted these principles, leading to implementations like massive transfusion protocols that reduced crystalloid use by up to 50% and improved early hemostasis in trauma patients.^[52] This synergy between surgical and resuscitative strategies enhanced outcomes in high-volume trauma systems, bridging wartime innovations back to urban emergency departments. Recent developments from 2020 to 2025 have expanded DCS beyond trauma to non-traumatic emergency general surgery (EGS), such as perforated viscera or ischemic bowel in unstable patients, as evidenced by systematic reviews showing lower observed mortality with staged approaches in these cohorts.^[19] The American Association for the Surgery of Trauma (AAST) has published on the application of DCS in EGS, advocating its use in resource-limited or physiologically deranged patients to facilitate source control before definitive intervention.^[53] Advancements in hybrid operating rooms, integrating imaging and endovascular capabilities, have enabled simultaneous damage control and interventional radiology, reducing operative times and complications in select centers.^[54] Improvements in trauma care have decreased the frequency of DCS in some systems. In 2024, the American College of Surgeons updated guidelines recommending massive transfusion protocols for managing life-threatening bleeding in abdominal trauma patients.^[55] A 2025 meta-analysis indicated that delaying planned reoperation beyond 48 hours after DCS reduces the risk of re-bleeding. Emerging evidence also supports standardized indications for DCS in pediatric trauma patients.^[56]^[57] Global adoption of DCS protocols reveals variations stemming from resource availability and injury patterns. International data indicate widespread adoption of open abdomen techniques associated with DCS in high-volume centers across Europe, North America, and Asia.^[58]

Outcomes and Complications

Survival and Efficacy Data

Prior to the widespread adoption of damage control surgery (DCS) in the 1990s, patients with exsanguinating penetrating abdominal injuries faced mortality rates approaching 89%, as traditional definitive surgical approaches often exacerbated the lethal triad of hypothermia, acidosis, and coagulopathy.^[2] The seminal 1993 study by Rotondo et al. demonstrated a marked improvement, achieving a 77% survival rate (23% mortality) in a cohort of 46 severely injured patients using an abbreviated DCS strategy, compared to historical controls with near-total mortality.^[1] Comprehensive reviews of over 1,000 DCS cases from 1976 to 1998 reported persistent mortality rates exceeding 50%, underscoring the challenges in early implementation but confirming overall survival gains in high-risk trauma populations.^[2] Comparative studies, though limited by the ethical challenges of randomization in unstable trauma patients, support DCS's superiority over definitive surgery for hemodynamically unstable individuals. A 2023 meta-analysis of 54 studies involving 5,247 patients found DCS associated with significantly reduced mortality (relative risk [RR] 0.27, 95% CI 0.22–0.34, P < 0.001) and higher rescue success rates (RR 1.36, 95% CI 1.29–1.44, P < 0.001) compared to traditional surgery.^[59] A 2025 systematic review and meta-analysis of 7 studies (including 1 randomized controlled trial) further indicated lower 30-day mortality with DCS (odds ratio [OR] 0.05, 95% CI 0.00–0.99, P = 0.010 in the RCT), although evidence certainty remains low due to heterogeneity.^[60] Efficacy of DCS is influenced by timely protocol activation and institutional experience, with high-volume trauma centers demonstrating optimized outcomes. Early recognition and initiation of DCS within the first hour of arrival can mitigate physiological derangement, contributing to survival benefits observed in integrated trauma systems.^[10] High-volume centers (performing >50 DCS cases annually) achieve comparable or lower mortality rates (around 30-40%) across diverse settings, including high- and middle-income countries, due to refined protocols and multidisciplinary coordination.^[61] Long-term data from 2024-2025 reinforce sustained efficacy when DCS is combined with damage control resuscitation (DCR) strategies, such as balanced transfusion and permissive hypotension. A 2025 analysis of over 4,000 DCS procedures reported a 32.4% mortality rate, with multivariable models highlighting DCR integration as a key factor in reducing complications and enhancing 30-day survival to 60-70% in select cohorts.^[62] These updates, building on 1990s origins in military medicine, affirm DCS's role in modern trauma care for unstable patients.^[2]

Associated Risks and Morbidity

Damage control surgery (DCS), particularly when involving an open abdomen, carries significant risks due to the intentional delay in definitive repair to prioritize physiological stabilization. One primary concern is abdominal compartment syndrome (ACS), which arises from intra-abdominal hypertension and can lead to organ dysfunction; its incidence in patients undergoing damage-control laparotomy has been reported as 10-20% in trauma cohorts, with higher rates (up to 33%) in select studies of unstable patients.^[63]^[64] Another notable complication is the development of enterocutaneous fistulas, occurring in 5-25% of cases managed with open abdomen techniques, often exacerbated by exposure of bowel to the external environment and repeated enterotomies during reoperations.^[65]^[66] Infections are also prevalent, including wound infections and ventilator-associated pneumonia, with open abdomen management increasing the risk of intra-abdominal sepsis and hospital-acquired infections due to prolonged exposure and contamination.^[67]^[68] Systemic effects further compound morbidity in DCS patients, stemming from the initial hypoperfusion and ongoing physiological stress. Prolonged intensive care unit (ICU) stays are common, averaging 7-14 days, driven by the need for hemodynamic monitoring and multiorgan support following the abbreviated procedure.^[69]^[70] Ventilator dependence frequently persists beyond the acute phase, with mean mechanical ventilation durations of 7 days or more, contributing to respiratory complications and weaning challenges.^[69] Renal failure, often resulting from intraoperative hypoperfusion and subsequent acute kidney injury (AKI), affects up to 20-30% of patients, manifesting as oliguria or the need for renal replacement therapy and prolonging recovery.^[71]^[72] Overall morbidity rates in DCS range from 40-60%, encompassing a spectrum of complications such as sepsis, wound dehiscence, and multiorgan failure, with rates approaching 53% in recent analyses of abdominal emergencies.^[73] Delayed reconstruction exacerbates these risks, as prolonged open abdomen duration correlates with higher fistula formation, infection rates, and fascial closure failure, increasing long-term ventral hernia incidence.^[74] Mitigation strategies focus on minimizing exposure and optimizing supportive care, including early abdominal closure protocols that aim for fascial reapproximation within 48-72 hours when physiologically feasible, as supported by 2024 guidelines emphasizing reduced complication profiles with timely definitive repair.^[56]^[53] Antibiotic stewardship, per recent 2025 recommendations, advocates for short-course prophylaxis (typically <24-48 hours post-closure) to curb resistance while covering penetrating trauma or contamination risks, integrated with temporary closure techniques like negative pressure wound therapy to isolate effluent and prevent infection.^[75]^[76]

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Indications for the surgical management of pancreatic trauma
Jun 27, 2022 · Damage control surgery is the best alternative for severe life-threatening cases. In such cases, the presence of severe acute pancreatitis ...
[15]
Emergency surgery damage control procedures: which, when and ...
This method aims to ensure the survival of the hemodynamically unstable patient through two basic principles: stop the bleeding and control contamination (1,2).Introduction · Damage control in emergency... · AMI · Footnote
[16]
Modern management of ruptured abdominal aortic aneurysm - PMC
Finally, it is strongly recommended to use “damage control” principles and a planned 2nd look operation after open repair of rAAA so deliberate placement of ...
[17]
Damage Control Surgery in Obstetrics and Gynecology - MDPI
Damage control surgery (DCS) is a staged surgical strategy for rapid control of life-threatening bleeding, followed by physiological stabilization and ...
[18]
Damage-control surgery in patients with nontraumatic abdominal
The aim of this study was to investigate the effect of DCS on mortality in patients with nontraumatic abdominal emergencies.Missing: applications post-
[19]
Damage control surgery–new concept or reenacting of a classical ...
Damage–control surgery is an example of a paradigm shift. The term is borrowed from naval terminology and means gaining the initial control of a damaged ship.
[20]
Damage Control Surgery for Abdominal Trauma - PMC - NIH
The goal of damage control is to preserve life. The triad of hypothermia, acidosis and coagulopathy once established in a patient of multiple injuries is lethal ...
[21]
Temporary Abdominal Closure Techniques - StatPearls - NCBI - NIH
Feb 24, 2024 · The drawbacks are the costs, the possibility of abdominal compartment syndrome formation, and the increased risk of enteric fistula formation by ...Missing: rationale | Show results with:rationale
[22]
https://www.ncbi.nlm.nih.gov/books/NBK564378/
[23]
Impact of initial temporary abdominal closure in damage control ...
Sep 15, 2018 · Use of vacuum-assisted dressings continues to be the preferred method for temporary abdominal closure in damage control surgery for trauma.
[24]
Temporary Closure of the Open Abdomen: A Systematic Review on ...
This study was designed to systematically review the literature to assess which temporary abdominal closure (TAC) technique is associated with the highest ...
[25]
Damage control in the injured patient - PMC - NIH
A review by Rotondo et al.[88] identified an overall 50% mortality and 40% morbidity in 961 damage control patients. The early reports of damage control surgery ...
[26]
https://pmc.ncbi.nlm.nih.gov/articles/PMC3259401/
[27]
Permissive Hypotension - StatPearls - NCBI Bookshelf - NIH
Mar 1, 2024 · Permissive hypotension is a deliberate strategy to maintain blood pressure at lower-than-normal levels in patients with trauma or hemorrhage.Introduction · Anatomy and Physiology · Contraindications · Technique or Treatment
[28]
https://journals.lww.com/jtrauma/fulltext/2017/03000/damage_control_resuscitation_in_patients_with.24.aspx
[29]
Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a ...
Feb 3, 2015 · Objective To determine the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and ...
[30]
https://pubmed.ncbi.nlm.nih.gov/21610356/
[31]
Damage Control Resuscitation | Military Medicine - Oxford Academic
Sep 5, 2018 · suggests limiting the use of crystalloids to one liter during initial resuscitation and incorporating early use of blood products including ...Blood Products For Dcr · Hemostatic Products For Dcr · Whole Blood<|control11|><|separator|>
[32]
Early crystalloid resuscitation in Trauma - ScienceDirect.com
Crystalloid administration during early resuscitation of bleeding trauma patients is recommended by current guidelines, yet evidence supporting this practice is ...
[33]
[PDF] War surgery : working with limited resources in armed conflict ... - ICRC
18.1 Resuscitative surgery and damage control surgery. 321. 18.2 Hypothermia ... humanitarian organizations who work in war zones face similar constraints.
[34]
Damage control surgery in the era of damage control resuscitation
Selection criteria for damage control management include the mechanism of injury and the degree of physiological derangement. Over the last two decades, public ...
[35]
Implementation of a military-derived damage-control resuscitation ...
A military-derived DCR strategy can be implemented in the civilian setting. DCR led to significant increases in FFP transfusion, decreases in crystalloid use, ...
[36]
[PDF] Damage control surgery in emergency general surgery
ABSTRACT: Damage-control surgery (DCS) is a strategy adopted to limit initial operative interventions in the unstable surgical patient, delaying definitive.
[37]
Damage Control Interventional Radiology: The bridge between non ...
Oct 3, 2024 · We review the literature for the role of DCS and utilization of IR in trauma, outcomes and the paradigm shift towards minimally invasive techniques.<|control11|><|separator|>
[38]
Decreasing the Use of Damage Control Laparotomy in Trauma - NIH
A decrease in the rate of DCL should decrease hospital resource utilization, decrease the rate of associated morbidities, and improve the quality of patient ...Missing: frequency | Show results with:frequency
[39]
Patients with an Open Abdomen in Asian, American and European ...
Nov 3, 2022 · The aim of our study is to compare the characteristics, management and clinical outcome of adult patients treated with OA in the three continents.Missing: variations | Show results with:variations
[40]
Is Damage Control Surgery Better than Traditional Surgery...
The study results indicated that 35% of patients with coagulopathy died in the simplified surgical group compared with 98% in the traditional surgery (TS) ...
[41]
Does damage control surgery for abdominal trauma have a real ...
Jul 7, 2025 · Mortality rates varied, with one observational study indicating higher 24-h mortality in the DCS group (OR 1.49, 95% CI 0.48, 4.68, I2 = 86%), ...Missing: 2023 | Show results with:2023
[42]
Damage Control Laparotomy: High-Volume Centers Display Similar ...
Jul 31, 2020 · Damage Control Laparotomy: High-Volume Centers Display Similar Mortality Rates Despite Differences in Country Income Level.Missing: factors influencing efficacy
[43]
After 4000 damage-control surgeries: Are we doing more ... - PubMed
Aug 18, 2025 · The mortality and major complications rates were 32.4% and 36%, respectively. On multivariable regression analysis, an increasing damage control ...
[44]
Avoidance of Abdominal Compartment Syndrome in Damage ...
Abdominal compartment syndrome is a frequent complication in patients requiring damage-control laparotomy. When ACS develops, it increases the incidence of ARDS ...
[45]
The open abdomen in trauma and non-trauma patients: WSES ...
Feb 2, 2018 · Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome.Missing: weaning | Show results with:weaning
[46]
Enterocutaneous Fistulas in the Setting of Trauma and Critical Illness
The open abdomen may represent particular increased risk for the development of ECF, also referred to as EAF when occurring in this setting (Fig. 1). Several ...
[47]
Current Status of the Open Abdomen Treatment for Intra‐Abdominal ...
Oct 2, 2013 · This specific complication, particularly enteroatmospheric fistula, is hard to prevent, with the overall incidence approximately 5–25% [30–32].
[48]
Complications of damage-control abdominal surgery: What you ...
Aug 13, 2025 · of infectious complications, including ventilator-associated pneumonia, bloodstream infections, surgical site infections, and increased ...
[49]
The Impact of Damage Control Laparotomy on Surgical Site ... - NIH
Damage control laparotomy (DCL) has been widely used in general surgery. However, associated surgical site infection (SSI) risks have rarely been investigated.
[50]
[PDF] Damage control surgery: 6 years of experience at a level I trauma ...
Average number of ventilator days, ICU stay, and hospital stay were 7 days (range: 1–30 days),. 9 days (range: 4–37 days), and 14 days (range: 9–45 days) re-.<|separator|>
[51]
Damage control in severely injured trauma patients – A ten-year ...
Intensive care unit length of stay for early survivors was 15.7±0.8 days and the mean hospital length of stay was 36.5±1.5 days. Overall, 59.6% (159 of 267) ...Missing: average | Show results with:average
[52]
Acute kidney injury in major abdominal surgery: incidence, risk ...
Feb 9, 2018 · Depending on the classification system employed in the studies, the reported incidence of AKI varies from 5.0 to 7.5% in hospitalized patients, ...
[53]
Advancements in Trauma-Induced Acute Kidney Injury - MDPI
Aug 13, 2024 · The incidence of AKI was found to be 24%, with onset within three days (range 1–6). More than half of these cases presented with mild AKI, and ...3. Renal Diagnostic... · 5. Holistic Trauma Care... · 5.2. Infusing Aki Management...
[54]
Predictive factors of mortality in damage control surgery for ... - NIH
Overall mortality was 59.6%. In the logistic regression stratified by survival, several variables were significantly associated with mortality, including ...Missing: post | Show results with:post
[55]
Early versus delayed complex abdominal wall reconstruction... - LWW
Damage-control surgery for trauma and intra-abdominal catastrophe is associated with a high rate of morbidities and postoperative complications.
[56]
Timing of planned reoperation after damage control surgery in ... - NIH
Oct 29, 2025 · The timing of planned reoperation was defined as the interval from the initial DCS to either formal reoperation or gauze pack removal. Studies ...Missing: phases reconstruction
[57]
[PDF] Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery
Primary prophylaxis refers to the prevention of an initial infection. Secondary prophylaxis refers to the prevention of recurrence or reactivation of a.Missing: mitigation | Show results with:mitigation
[58]
Guidelines for Enhanced Recovery After Trauma and Intensive Care ...
Jul 22, 2025 · Infection prevention strategies include antimicrobial stewardship, sensitivity surveillance, and rational short-course antimicrobial therapy ( ...