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Health Level 7

(HL7) is an ANSI-accredited, not-for-profit standards developing organization founded in 1987 that provides a comprehensive framework of international standards for the exchange, integration, sharing, and retrieval of electronic health information to support clinical practice and the management, delivery, and evaluation of health services. The organization's mission is to empower global health data to improve human and economic health outcomes through collaborative development of technical standards and implementation guides. The name "Health Level Seven" originates from its emphasis on the application layer—Layer 7—of the Open Systems Interconnection (OSI) reference model, which governs data interchange at the application level in healthcare systems. HL7's development traces back to the late with precursor protocols like StatLAN at the Medical Center, which connected minicomputers for patient data exchange by 1981; the formal organization was established in 1987 with initial standards published that year to address fragmented healthcare IT interoperability. In 1994, HL7 became accredited by the (ANSI), marking its evolution into a mature standards development organization, and it now operates with members from over 50 countries, including healthcare providers, vendors, and government agencies. HL7's primary standards families include , a widely adopted messaging protocol for clinical and administrative data exchange between systems; the Version 3 (V3) suite, based on a Reference Information Model for more formalized semantics; (CDA) Release 2, a document markup standard for creating structured, interoperable clinical documents such as discharge summaries and referrals; and (FHIR), a modern, RESTful standard using resources for efficient, web-friendly health data exchange that has gained significant traction since its initial release in 2011. These standards are licensed for free use in primary forms and are integral to U.S. regulations, such as the (CMS) Quality Payment Program, as well as global initiatives for electronic health records and reporting. HL7's work extends beyond standards development to include certification programs, educational resources, and accelerators like FHIR-based projects for specific use cases such as and patient data exchange, fostering widespread adoption in electronic health records (EHRs), laboratory systems, and payer-provider interactions worldwide. With ongoing updates—such as FHIR Release 5 in —and initiatives like the AI Office launched in 2025, HL7 continues to address emerging challenges in healthcare , including integration and international patient summaries.

Introduction

Definition and Purpose

(HL7) is a not-for-profit, ANSI-accredited standards-developing dedicated to providing a comprehensive framework and related standards for the exchange, integration, sharing, and retrieval of electronic health information to support clinical practice and the management, delivery, and evaluation of health services. As the name implies, HL7 focuses on the —Layer 7—of the Open Systems Interconnection (OSI) model, defining protocols for application-to-application communication in healthcare settings. This scope encompasses the transfer of clinical and administrative data, such as patient admissions, discharge summaries, medication orders, laboratory results, and billing information, enabling disparate healthcare systems to communicate effectively. The core purpose of HL7 standards is to facilitate seamless among healthcare applications, thereby improving patient care through timely access to accurate information, reducing medical errors associated with data silos, and enhancing administrative efficiency by streamlining processes like claims processing and reporting. By standardizing data formats and messaging protocols, HL7 minimizes the need for costly custom integrations between vendor systems, supports the implementation of electronic health records (EHRs), and helps organizations comply with regulations such as the Health Insurance Portability and Accountability Act (HIPAA) by promoting secure data exchange practices. These standards have evolved from early messaging protocols to modern resources like (FHIR), adapting to the growing demands of ecosystems. Although HL7 standards are voluntary, they are widely adopted globally due to their proven reliability and broad applicability, with over 90% of U.S. healthcare organizations utilizing HL7 Version 2 for as of 2024. This high adoption rate underscores HL7's role in fostering a connected healthcare that prioritizes and operational effectiveness.

Historical Development

Health Level Seven (HL7) was founded in 1987 as an ad-hoc working group comprising healthcare vendors, providers, and consultants to address the growing need for standardized electronic data exchange in healthcare environments, particularly for hospital information systems. This initiative emerged from earlier efforts in the late at institutions like the Medical Center, but formalized into HL7 to create interoperable protocols amid fragmented systems. The organization's first major output was HL7 Version 2 (v2), released in October 1987, which introduced pipe-delimited messaging for real-time data sharing, such as admissions, discharges, and lab results, emphasizing flexibility over rigid structure. Key milestones marked HL7's maturation into a formal standards body. In 1994, HL7 received accreditation from the (ANSI), affirming its standards as national benchmarks for healthcare . Development of HL7 Version 3 (v3) began in the late , around 1997, incorporating the Reference Information Model () to provide a more rigorous, model-driven approach for comprehensive clinical data representation. The initial v3 standard was released in 2005, shifting focus toward XML-based, semantically precise messaging to support broader workflows beyond v2's hospital-centric scope. The launch of (FHIR) in 2011 represented a pivotal evolution, designed as a next-generation leveraging modern web technologies like RESTful APIs and for simpler, resource-oriented data exchange. FHIR gained prominence post-2014 with its first draft for trial use, addressing limitations in prior versions by prioritizing ease of implementation and developer-friendly syntax. In 2023, HL7 released FHIR Release 5 (R5), enhancing capabilities for data and modular extensions while maintaining . By 2025, global surveys indicated FHIR adoption had reached 71%, reflecting its widespread integration in electronic health records and applications across countries. Throughout its history, HL7's standards evolved from v2's flexible, widespread but implementation-variable adoption—used in over 90% of U.S. hospitals by the early —to v3's more formal but complex modeling, which saw slower uptake due to its intricate requirements and steep learning curve. This complexity limited v3's penetration, prompting FHIR's design for streamlined web-based interoperability that balances precision with accessibility, driving accelerated global implementation.

Organization and Governance

Founding and Structure

(HL7 International) was founded in March 1987 in , as a not-for-profit standards-developing organization dedicated to facilitating the exchange of clinical and administrative data in healthcare. The initiative emerged from a collaborative effort among healthcare IT vendors and professionals seeking to establish common frameworks for amid growing needs for electronic . Headquartered in Ann Arbor, Michigan, HL7 International maintains a global presence through affiliates in over 30 countries, enabling localized adaptation and adoption of its standards worldwide. The organization's structure includes a Board of Directors with elected and appointed positions, an executive committee overseeing strategic direction, and a professional staff of approximately 50 employees. Its operations are supported by an annual budget of roughly $10 million, derived primarily from membership dues and related activities. Membership exceeds 4,000 individuals from more than 500 organizations, including healthcare vendors, providers, agencies, payers, and consultants, representing over 90% of major healthcare systems vendors. As a 501(c)(6) non-profit business league, HL7 has been accredited by the (ANSI) since 1994, ensuring rigorous processes for standards development.

Standards Development Process

The Health Level Seven International (HL7) standards development process is consensus-driven, involving collaborative input from its global community of healthcare professionals, vendors, and stakeholders to ensure standards meet real-world needs. Workgroups, such as those focused on Patient Care or and Messaging, initiate proposals for new standards or updates by submitting project scope statements through the HL7 Project Insight tool, which outlines objectives, timelines, and resources required. These proposals advance only after approval by the sponsoring workgroup and oversight from the Technical Steering Committee (TSC), which coordinates technical activities across all workgroups to maintain alignment with HL7's strategic goals. Central to the process is the balloting mechanism, which solicits structured feedback to refine specifications. Ballots are categorized as for comment (early feedback without publication), informative (non-binding guidance), Standard for Trial Use (STU, implementation-ready but time-limited), or normative (binding and stable, with strict backward compatibility). Three regular ballot cycles occur annually, aligned with HL7 Work Group Meetings, supplemented by out-of-cycle ballots as needed; participants, including members and non-members, submit comments via the JIRA Ballot Desktop tool. Following the ballot period, workgroups conduct reconciliation meetings to review and disposition comments—categorizing them as persuasive, not persuasive, or other—often requiring recirculation ballots for unresolved normative issues. Adoption thresholds vary: informative and STU ballots require at least 60% affirmative votes, while normative ballots demand a quorum of over 50% of eligible voters and 75% affirmative support, excluding abstentions. Public comments from external stakeholders are integrated throughout, fostering broad consensus per ANSI-accredited procedures outlined in HL7's Governance and Operations Manual. Tools and methodologies support efficient development, particularly for modern standards like (FHIR). FHIR specifications leverage repositories for , enabling collaborative editing, pull requests, and builds via automated pipelines that generate draft publications around the clock. harmonization occurs through dedicated meetings where workgroup representatives propose and vote on code system changes to ensure consistency across HL7 products. In contrast to the more ad-hoc evolution of HL7 Version 2, FHIR employs agile practices, including iterative releases and community-driven implementation guides. The full lifecycle—from project initiation to publication—typically spans 1-3 years, depending on complexity and feedback volume, with maintenance occurring post-publication via STU updates or normative editions. FHIR follows a major release cadence, exemplified by Release 5 (R5) published in 2023 after extensive balloting and testing. By 2025, HL7 has produced over 200 work products, including core standards like Version 2 and FHIR, reflecting the organization's commitment to evolving solutions.

Core Standards

HL7 Version 2

HL7 Version 2 (V2) is a messaging standard for the exchange of clinical and administrative data between healthcare applications, widely adopted since its initial development in the late 1980s. The first version, 2.1, was published in 1988, with subsequent updates addressing evolving needs in areas such as admissions, discharges, lab orders, and pharmacy management. V2 messages are text-based, using pipe (|) delimiters to structure segments that represent discrete data elements, such as patient demographics or result observations, transmitted via protocols like TCP/IP or MLLP (Minimal Lower Layer Protocol). Unlike more formal standards, employs a flexible, event-driven approach where messages are triggered by clinical events (e.g., ADT for admissions), allowing customization through Z-segments for site-specific data while maintaining core . Key versions include 2.3.1 (1995) for enhanced international support and 2.5.1 (2007) as the current base, with ongoing maintenance through version 2.9. By 2025, remains the most prevalent HL7 standard globally, used in over 90% of U.S. healthcare interfaces and extensively in legacy systems worldwide, though its textual format poses challenges for semantic precision compared to newer standards.

HL7 Version 3

HL7 Version 3 (v3) represents a model-driven approach to healthcare , centered on the Reference Information Model (), which serves as a comprehensive for representing clinical and administrative data across healthcare domains. The provides a unified, static that categorizes into core concepts, enabling the derivation of standardized messages for exchange between systems. These messages are encoded in XML format, ensuring structured and extensible representation of data elements such as patient records, observations, and procedures. Development of HL7 v3 began in the mid-1990s, with the first normative release occurring in 2005, building on object-oriented modeling techniques. The standard employs an abstract syntax notation, inspired by , to define data types and derive message structures from the , allowing for precise specification of semantics independent of implementation technology. Key elements include interactions, which encapsulate specific exchanges like queries for patient data and corresponding responses, often wrapped in envelopes for transmission. These interactions support various payload types tailored to domains such as care provision and laboratory reporting. The backbone consists of over 100 classes, with top-level abstractions including (representing events like diagnoses or treatments), (physical or logical objects such as patients or materials), and (relationships between entities and acts, like a physician's involvement in a ). This structure enables precise semantics, facilitating complex scenarios such as public health reporting for and tracking. However, the standard's high complexity in modeling and implementation has resulted in limited global adoption, with primary use in regions like and parts of Europe where regulatory mandates support it. The RIM's foundational role extends to influencing subsequent standards, including the (CDA) and elements of (FHIR).

Fast Healthcare Interoperability Resources (FHIR)

(FHIR) is a standard developed by (HL7) for exchanging electronic healthcare information, emphasizing simplicity and compatibility with contemporary web standards. It employs RESTful web services to enable CRUD (create, read, update, delete) operations on healthcare data, supporting serialization in and XML formats for flexibility across devices and systems. At its core, FHIR uses discrete, modular resources as building blocks—such as the resource for demographic details or the resource for clinical measurements—which can be queried, combined, and manipulated via standardized to support diverse workflows like patient registration or lab result sharing. This resource-centric approach draws briefly from HL7 Version 3's Reference Information Model () for foundational while prioritizing ease of implementation over rigid schemas. FHIR's evolution spans multiple releases, starting with Draft Standard for Trial Use 1 (DSTU1) in 2011, which introduced initial resource definitions and patterns, followed by DSTU2 in 2015 for enhanced maturity, STU3 in 2017 with improved validation tools, R4 in 2019 as the first normative edition for key resources, and R5 in 2023 incorporating refinements for maturity and usability. R5 achieved normative status for additional core resources, stabilizing them against breaking changes to accelerate enterprise adoption. Key features include its modular architecture, where profiles constrain base resources for specific contexts (e.g., tailoring for pediatric care) and extensions add non-core elements without altering the standard. FHIR integrates the SMART on FHIR framework to facilitate secure third-party applications, leveraging 2.0 for and to ensure controlled access within electronic health records. Additionally, it employs services compatible with standards like for clinical findings and LOINC for laboratory observations, promoting . The standard's strengths lie in its web-native design, which supports mobile-friendly integrations and simplifies connectivity for developers, reducing implementation time compared to prior HL7 versions. This enables patient-centric applications, such as apps for self-tracking or sharing records across providers, and paves the way for AI-driven tools like on aggregated observations. With over 150 defined resources covering domains from to clinical , FHIR uses OAuth-based security profiles to protect sensitive data exchanges. It also offers with HL7 Version 2 through defined mappings and interface specifications, allowing hybrid systems to transition gradually. By 2025, FHIR achieved 71% global adoption among healthcare organizations for data exchange, driven by its alignment with regulatory priorities. In the United States, the Office of the National Coordinator for Health Information Technology (ONC) mandates FHIR via the rules, requiring certified health IT to support patient access APIs and prohibit information blocking, thereby fostering nationwide .

Document and Data Standards

Clinical Document Architecture

The Clinical Document Architecture (CDA) is an XML-based markup standard developed by (HL7) to specify the encoding, structure, and semantics of clinical documents, enabling the creation of human-readable documents that also contain machine-processable data for across healthcare systems. CDA documents are designed to persist independently, ensuring characteristics such as stewardship by an organization, authentication by a responsible party, contextual relevance to a specific encounter or care setting, wholeness as a complete unit of information, and inherent human readability even when rendered from the XML source. Rooted in the HL7 Version 3 Reference Information Model (RIM), CDA leverages its classes and attributes to derive semantic meaning, facilitating structured exchange of clinical information like progress notes, discharge summaries, and diagnostic reports. CDA defines three levels of conformance to balance flexibility with increasing structure and . Level 1 provides minimal constraints, allowing a basic document header and unstructured body content, suitable for simple exchanges where full semantics are not required. Level 2 introduces section-level templates, organizing the body into labeled sections (e.g., medications, allergies) with text and optional coded entries for better and partial . Level 3 offers the highest granularity, mandating entry-level templates with coded clinical statements (e.g., observations, procedures) linked to vocabularies like or LOINC, enabling advanced querying and aggregation of discrete data elements. Key components of a document include a mandatory header and body, enforced through XML schemas and implementation guides. The header captures such as the document's legal authenticator, creation and effective dates, demographics, details, and custodian information, ensuring and context. The body comprises nestable sections—such as history of present illness, physical exam, or plan of care—each potentially containing structured entries (e.g., coded problems or results) alongside blocks for human interpretation; templates, defined in HL7 implementation guides, promote consistency by constraining allowable content and vocabularies within these sections. In practice, CDA supports critical applications like electronic health record (EHR) summaries and discharge summaries, allowing seamless sharing of data during care transitions. It integrates with (FHIR) through the DocumentReference resource, which indexes CDA documents for retrieval and reference in FHIR-based ecosystems without altering the underlying CDA content. A prominent derivative is the Continuity of Care Document (CCD), a U.S.-specific CDA template that standardizes summaries with sections for allergies, medications, problems, and immunizations, facilitating nationwide interoperability under initiatives like Meaningful Use. CDA Release 1.0 achieved (ANSI) approval in November 2000, marking it as HL7's first document standard within the Version 3 family. By 2023, over 90% of U.S. health information exchanges (HIEs) routinely exchanged CDA documents, underscoring its entrenched role in clinical data sharing.

Other Specialized Standards

HL7 has developed several specialized standards that address niche areas beyond core messaging and document exchange, focusing on decision support, product labeling, architectural frameworks, and application integration. These standards enable targeted functionalities such as clinical logic representation, regulatory compliance for pharmaceuticals, service-oriented interoperability, and real-time context synchronization across applications. The Arden Syntax is a rule-based language designed for creating Medical Logic Modules (MLMs) that support clinical decision-making in healthcare systems. It allows for the explicit representation of medical knowledge in an executable format, facilitating the sharing of decision support rules across different platforms and institutions. Originally published by the American Society for Testing and Materials (ASTM) in 1992 as version 1.0, the standard was adopted by HL7 with version 2.0 published in 1999, with ongoing maintenance by the HL7 Arden Syntax Work Group. Arden Syntax emphasizes simplicity and portability, using a structured format with slots for maintenance, library, knowledge, and action components to define triggers, conditions, and responses in decision support systems. Clinical Quality Language (CQL) serves as an expression language for representing clinical decision logic, particularly in quality measurement and decision support artifacts. It provides a human-readable, high-level syntax for querying and manipulating clinical data, enabling the computation of quality measures and eligibility criteria. First formally published by in 2015 (STU Release 1), following a 2014 draft, as part of the Clinical Quality Framework initiative, CQL has evolved through multiple releases, with version 1.5.3, the current normative standard as of March 2025. CQL integrates with standards like by allowing logic to be expressed against FHIR resources, supporting applications such as electronic clinical quality measures (eCQMs). Structured Product Labeling (SPL) is an XML-based standard for the electronic representation of product labeling information, ensuring structured and machine-readable content for regulatory submissions and distribution. It defines elements for drug facts, indications, warnings, and dosing, based on the HL7 Reference Information Model (RIM). Approved by HL7 and adopted by the U.S. Food and Drug Administration (FDA), SPL became mandatory for electronic labeling submissions to the FDA's Center for Evaluation and Research (CDER) starting October 31, 2005, with expansions to biologics in 2008 and over-the-counter products in 2009. The Services Aware Interoperability Framework () provides an architectural framework for developing service-oriented HL7 standards, promoting consistency and traceability across specifications. It organizes into governance, implementation fabric, and behavioral viewpoints to guide the design of robust, scalable healthcare interfaces. Released in 2014 as HL7 SAIF Canonical Definition, version 2.0 (retired November 2024), SAIF has influenced subsequent standards like FHIR by emphasizing service-oriented principles for enhanced modularity and reusability. The Clinical Context Object Workgroup (CCOW) standard, now known as HL7 Context Management, enables real-time synchronization of context across multiple clinical applications, such as patient selection and . It uses a publish-and-subscribe model to manage shared contexts like ID or location, supporting features like without proprietary integrations. First specified in 1998 as version 1.0 by the HL7 CCOW work group, it was integrated into the Infrastructure and Messaging work group in 2010, with the latest version 1.11 released in 2015. HL7's Electronic Health Record-System Functional Model (EHR-S FM) and Personal Health Record-System Functional Model (PHR-S FM) outline functional specifications for EHR and PHR systems, emphasizing requirements such as efficiency, data , and consistency rather than data exchange formats. These models, first released in 2004 and updated to release 2.1 in 2020 (adopted as ISO/HL7 10781 in 2023), serve as normative references for and , defining conformance criteria for functions like care management and .

Implementation Aspects

Message Structure and Transmission

HL7 messages follow a standardized consisting of multiple , each representing a logical unit of . The message begins with the mandatory MSH (Message Header) segment, which specifies the message type, sender, receiver, date-time of creation, and encoding parameters. Following the header, the body contains variable tailored to the message purpose, such as the (Patient Identification) segment for demographic details and the OBR (Observation Request) segment for details on requested observations or tests. The message concludes with trailer , including the (Message Acknowledgment) segment, which conveys acceptance or rejection status. This segmental architecture allows for flexible assembly while ensuring consistent parsing across systems. Messages are triggered by specific events defined in HL7 standards, known as trigger events, which dictate the message type and content. For instance, the A01 trigger event initiates an ADT/ACK for patient admission or visit notification, while the ORU trigger event supports unsolicited transmission of observation results, such as lab findings. These events enable both asynchronous communication, where messages are sent upon occurrence without expectation of immediate response, and query-response patterns, where a request prompts a targeted reply. Trigger events are encoded in the MSH-9 field to identify the message's purpose. Transmission of HL7 messages commonly employs the Minimal Lower Layer Protocol (MLLP) over /IP, which wraps the message content with a start-of-message byte (0x0B), the HL7 , and an end-of-message byte (0x1C) followed by a , facilitating reliable stream-based delivery without higher-layer protocols. MLLP ensures messages are delimited clearly in continuous streams, supporting bidirectional exchanges in environments like hospital information systems. For standards like FHIR, transmission shifts to HTTP-based methods, leveraging RESTful APIs for request-response interactions over the web. Encoding rules define how data within segments is formatted and separated. In HL7 Version 2, the pipe (|) serves as the field separator, the caret (^) as the component separator, the tilde (~) for repetitions, and the ampersand (&) for subcomponents, with these delimiters declared in MSH-1 through MSH-2 for customization if needed; the standard recommends fixed values for interoperability. HL7 Version 3 employs XML as its primary encoding, structuring messages hierarchically with tags for elements like interactions and payload wrappers. Similarly, FHIR supports both XML and JSON encodings, enabling compact, human-readable serialization of resources over web protocols. The OBR segment plays a central role in observation-related messages, detailing the request with fields such as OBR-2 (Placer Order Number), which identifies the from the requesting , and OBR-3 (Filler Order Number), assigned by the performing to fulfillment. These fields link orders across systems, with the placer number often generated by an ordering application like an EHR and the filler number by a or . The OBR segment is commonly used in Version 2 messages, particularly in observation result transmissions like ORU, underscoring its prevalence in clinical workflows. Error handling in HL7 messaging relies on acknowledgment mechanisms, where receiving systems issue negative acknowledgments (NACKs) to signal issues. In Version 2, the MSA segment carries codes like (application error) or (application reject) in a NACK response, detailing the error via subsequent ERR segments, prompting the sender to retry or correct. This ensures robust transmission by isolating failures at the application level without disrupting the overall exchange.

Interoperability Challenges

One of the primary interoperability challenges with HL7 standards stems from systems, particularly HL7 Version 2 (), which exhibits significant variations across implementations due to its flexible, pipe-delimited messaging format. These variations often necessitate custom mappings to align data between disparate systems, as vendors frequently introduce proprietary extensions like Z-segments to accommodate site-specific needs, leading to conflicts and reduced standardization. HL7 Version 3 (v3) introduces additional complexity through its -based approach, which imposes a steep on developers and implementers due to its abstract, object-oriented structure and extensive documentation requirements. Similarly, faces vendor inconsistencies in profile usage, where differing interpretations of resource extensions and conformance rules result in fragmented data exchange, hindering seamless integration across systems. Security and privacy risks further complicate HL7 implementations, especially in data transmission over networks, where unencrypted messages or inadequate access controls can expose sensitive patient information to breaches. For FHIR specifically, the need for robust, HL7-aligned security frameworks like on FHIR arises to enforce OAuth-based authorization and ensure fine-grained to resources, mitigating risks associated with API-driven exchanges. Implementation costs represent a substantial barrier, with HL7 interface integrations typically ranging from $50,000 to $750,000 per , encompassing development, testing, and maintenance expenses that strain healthcare organizations' budgets. Training gaps exacerbate these issues, as evidenced by 2025 surveys indicating that 59% of respondents identify insufficient FHIR knowledge as a primary to adoption. Regulatory compliance adds another layer of difficulty, requiring HL7 systems to align with stringent data protection laws such as HIPAA in the United States and GDPR in Europe, which demand robust consent management and audit trails amid varying global adoption rates— for instance, only 71% of countries reported active FHIR use in at least a few cases in 2025. Knowledge gaps remain the top barrier to interoperability, as highlighted in HL7's 2025 State of FHIR report, underscoring the need for enhanced education and standardized guidelines to bridge these divides.

Adoption and Impact

Global Usage and Case Studies

In the United States, HL7 2 remains the dominant for healthcare , with approximately 95% of healthcare organizations utilizing it for purposes. Since 2022, the Office of the National Coordinator for Health Information Technology (ONC) has mandated that certified electronic health records (EHRs) support (FHIR) APIs, facilitating patient access to through standardized interfaces. By 2025, more than 90% of U.S. hospitals have adopted FHIR-enabled systems, enhancing sharing across providers. In , FHIR adoption is advancing through the EU eHealth Network, which has selected HL7 FHIR as the base standard for implementing cross-border use cases such as laboratory results exchange. HL7 Version 3 continues to underpin national systems, notably in the United Kingdom's (NHS), where it supports services like the Personal Demographics Service for accessing patient information and pathology messaging for laboratory test requests and results. Globally, HL7 maintains affiliates in over 30 countries, fostering localized standards development and implementation. A 2025 survey by HL7 International and Firely indicated that 71% of respondents reported active FHIR use in their countries for at least a few use cases, reflecting accelerating adoption amid challenges such as version fragmentation. Notable case studies illustrate HL7's practical application. Epic Systems has integrated FHIR APIs into its EHR platform, enabling patient portals that allow secure access to health records and third-party app connectivity, thereby supporting patient-centered data exchange. The U.S. Centers for Disease Control and Prevention (CDC) employs HL7 Version 2.5.1 for immunization information systems (IIS), using implementation guides to standardize messaging for vaccine data submission and retrieval across registries. HL7 standards have significantly reduced data silos in healthcare, promoting seamless information flow between disparate systems and improving care coordination. For instance, implementations have led to enhanced efficiency, such as faster processing of laboratory results through standardized exchanges. In developing countries, HL7 supports (WHO) initiatives by providing open interoperability standards for basic EHR systems, enabling global data sharing and strengthening health information infrastructure.

Future Directions

The maturation of (FHIR) continues with Release 6 (R6) planned for normative status in late 2026, with widespread production adoption anticipated by 2027 to enhance stability and broader . This release aims to advance integration of and (AI/ML) capabilities through ongoing HL7 projects, such as those developing FHIR Implementation Guides for AI transparency. HL7's AI Focus Team is advancing these efforts by prioritizing data lifecycle management for AI/ML in healthcare workflows, ensuring ethical and secure applications. Harmonization initiatives are expanding FHIR compatibility with complementary standards, including for detailed clinical modeling and OMOP for observational data analytics, to streamline and reduce silos. A key enabler is the Unified Terminology Governance (UTG) program, which centralizes global management to support consistent coding across these ecosystems and foster international . Current priorities include advancing bulk data transfer protocols to enable efficient large-scale sharing and strengthening payer-provider exchanges to support seamless administrative and clinical coordination. The Da Vinci Project exemplifies this focus by developing FHIR-based implementation guides tailored for U.S. value-based care, facilitating and coverage data flows between payers and providers. Looking ahead, challenges involve transitioning legacy systems like HL7 Version 2 to modern standards, alongside efforts to promote equity by adapting FHIR for low-resource settings through simplified implementation guides and (SDOH) integrations. The Gravity Project under HL7 is addressing equity by standardizing SDOH data to support inclusive care in underserved areas. In 2025, notable initiatives include the U.S. Food and Drug Administration's (FDA) exploration of FHIR for standardizing clinical trial data submissions from real-world sources, aiming to accelerate regulatory reviews. These efforts align HL7 standards with United Nations Sustainable Development Goals, particularly SDG 3 on health and well-being, by enhancing data accessibility for global public health monitoring. Strategically, HL7 is shifting emphasis from developing expansive base standards to prioritizing practical implementation guides (IGs), which provide targeted, use-case-specific profiles to accelerate real-world deployment and reduce adoption barriers. This approach builds on FHIR's growing adoption by focusing resources on IGs for emerging needs like integration and cross-standard harmonization.

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