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Masked depression

Masked depression, also known as concealed or hidden depression, refers to a presentation of major depressive disorder (MDD) in which somatic (physical) symptoms predominate over classic psychological symptoms such as persistent sadness or loss of interest, often leading to misdiagnosis as a purely physical condition.^[1] Somatic symptoms, a key feature of masked depression, affect approximately 65% of individuals with MDD, with unexplained painful physical symptoms (UPPS) like chronic back, joint, or headache pain occurring in up to 77% of cases in large outpatient cohorts.^[1] Common somatic symptoms include fatigue, gastrointestinal disturbances, sleep disturbances, and musculoskeletal aches, while subtler psychological features may involve anhedonia, anxiety, and concentration difficulties that are frequently overlooked.^[1]^[2] The term "masked depression" originated in the 1970s and 1980s to describe patients presenting with somatic complaints without evident mood changes, and it is recognized in ICD-10 under other specified depressive episodes, but it is not included in ICD-11 or DSM-5, where it falls under somatic symptom disorder or MDD with prominent physical features.^[2]^[3] Although the term is historical, the presentation continues to be recognized under alternative classifications in contemporary psychiatry (as of 2025).^[4] Neurobiologically, it involves dysregulation in frontal-limbic circuits, elevated proinflammatory cytokines (e.g., IL-6 and TNF-α), and impaired pain-modulating pathways, contributing to the overlap between emotional distress and physical pain.^[1] Diagnosis remains challenging, particularly in primary care settings where over 50% of cases may be missed, as patients often seek nonpsychiatric treatment and undergo unnecessary investigations; targeted screening for sleep patterns, anhedonia, and somatic scales like the Patient Health Questionnaire-15 is recommended.^[2] Treatment typically includes serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine, which alleviate both pain and mood symptoms in 30–70% of cases independently of antidepressant effects, alongside cognitive-behavioral therapy to address underlying emotional components.^[1] Early recognition is crucial, as masked depression predicts poorer response to standard antidepressants and prolonged remission times compared to typical MDD.^[1]

Definition and Historical Context

Definition

Masked depression refers to a form of depression in which somatic symptoms predominate over the classic emotional or mood-related symptoms, often resulting in misdiagnosis as a purely physical condition.^[5] In this presentation, individuals experience physical complaints such as chronic pain, fatigue, or gastrointestinal disturbances, while overt signs of sadness or anhedonia may be absent or minimal, effectively concealing the underlying depressive disorder.^[6] The term encapsulates this "hidden" nature, where the psychological core of depression is obscured by bodily manifestations.^[7] The concept emerged in the mid-20th century, gaining prominence in the 1970s and 1980s, to describe how depression can manifest primarily through somatic channels, particularly in cultural or social contexts where expressing emotional distress is stigmatized or suppressed.^[5] This framing highlighted the need to recognize non-typical depressive expressions beyond traditional mood criteria.^[8] Although influential in earlier psychiatric literature, masked depression is not recognized as a formal subtype in contemporary diagnostic systems such as the DSM-5; instead, it serves as a descriptive pattern within major depressive disorder (MDD), emphasizing atypical somatic-dominant features that align with broader categories like somatic symptom disorder.^[9]^[10]

History of the Concept

The concept of masked depression first emerged in European psychiatry during the late 1950s as a way to describe depressive states where somatic symptoms predominated over typical mood disturbances. Swiss psychiatrist Paul Kielholz introduced the term in 1957, characterizing it as an endogenous or psychogenic depression masked by physical complaints, often in middle-aged individuals, to highlight cases where emotional symptoms were obscured by bodily manifestations.^[11] This idea gained initial traction in the 1960s through clinical observations in psychosomatic contexts, addressing how depression could present without overt psychological signs, particularly in populations less likely to verbalize emotional distress.^[12] In the 1970s and 1980s, the concept expanded significantly within psychosomatic medicine, with studies emphasizing its relevance to cultural and social factors that suppress emotional expression, such as traditional gender roles in men and age-related stoicism in older adults. Key publications, including Kielholz's edited volume Masked Depression (1973) and Stanley Lesse's Masked Depression (1974), formalized the syndrome by compiling clinical cases and proposing diagnostic frameworks centered on somatic equivalents like pain and gastrointestinal issues as proxies for underlying depression.^[13] ^[14] Researchers like Frank J. Ayd further promoted its recognition in the mid-1970s, linking it to broader efforts in psychopharmacology to identify hidden mood disorders for antidepressant intervention, which helped integrate it into general medical practice.^[15] During this period, masked depression was frequently diagnosed in patients with unexplained somatic complaints, reflecting its utility in bridging psychiatry and primary care.^[16] By the 1990s, the term began to wane as psychiatric nosology shifted toward more empirically grounded categories, with masked depression absorbed into discussions of atypical depression and somatization disorders. The DSM-III (1980) and subsequent editions avoided endorsing it as a distinct entity, favoring criteria focused on psychological factors affecting physical conditions, while DSM-5 (2013) reframed such presentations under somatic symptom and related disorders, emphasizing distress and impairment over hidden depression. It was briefly recognized in the ICD-10 (effective 1994) under other specified depressive episodes (e.g., F32.89 for single episode of 'masked' depression NOS), but this specific exemplification is absent in ICD-11 (effective 2022).^[17]^[18]^[19]^[20]

Clinical Presentation

Somatic Symptoms

Masked depression is characterized by a predominance of somatic symptoms that overshadow the typical affective and cognitive features of depression, leading patients to seek medical attention primarily for physical complaints. Common manifestations include chronic headaches, back pain, abdominal pain, gastrointestinal disturbances such as constipation or diarrhea, persistent fatigue, sleep disturbances like insomnia or hypersomnia, and nonspecific musculoskeletal aches.^[2] These symptoms are often vague and diffuse, affecting multiple body systems without clear organic pathology.^[21] The presentation of these somatic symptoms in masked depression frequently mimics chronic medical conditions, resulting in persistent complaints that do not respond to conventional treatments.^[22] Patients may report these issues as their sole concern, with symptoms waxing and waning but generally enduring for months, often prompting repeated consultations with primary care providers before psychiatric evaluation.^[2] This pattern contributes to diagnostic delays, as the physical focus obscures the underlying mood disorder.^[23] Physiologically, these somatic symptoms arise from psychosomatic mechanisms where chronic stress and depressive states heighten pain perception and bodily discomfort through dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, leading to elevated cortisol levels, alongside imbalances in neurotransmitters such as serotonin and norepinephrine that modulate pain and autonomic responses.^[24] Inflammation and altered central sensitization further amplify these effects, linking emotional distress to heightened somatic awareness without identifiable structural damage.^[24] In clinical scenarios, a middle-aged patient might present with unrelenting low back pain and fatigue unresponsive to physical therapy, only later revealing depressive symptoms upon targeted questioning, illustrating how somatic complaints can initially dominate and delay recognition of masked depression.^[23] Similarly, individuals reporting chronic abdominal pain and sleep disturbances may undergo extensive gastrointestinal workups before the psychosomatic overlay is considered, highlighting the progression from isolated physical reports to integrated diagnosis.^[21]

Psychological Features

Masked depression is characterized by subtle psychological manifestations that are often overshadowed by somatic complaints, including hidden mood indicators such as irritability, anxiety, and anhedonia rather than explicit sadness.^[25] Irritability frequently emerges as a prominent emotional response in patients with severe masked depression, serving as an indirect expression of underlying affective distress.^[25] Anxiety often acts as a proxy for the depressive state, with patients exhibiting anxious-hypochondriacal traits that mask the core mood disturbance.^[12] Anhedonia, or loss of interest and pleasure in previously enjoyable activities, is a key feature, though patients typically deny overt depressed mood. Emotional numbness may also prevail, contributing to a facade of normalcy. Cognitive aspects in masked depression involve impairments such as concentration difficulties, indecisiveness, and pessimistic cognitions that are frequently concealed by a focus on physical ailments.^[2] For instance, 31% of psychiatrists reported lack of concentration in more than half of their patients, highlighting its prevalence as a subtle marker.^[2] Indecisiveness and negative views of self, world, and future—elements of Beck's cognitive triad—can be obscured in this presentation, particularly in older adults where somatic preoccupation dominates.^[17] These cognitive disruptions often exacerbate the denial of psychological distress, leading patients to attribute mental fog to bodily issues rather than emotional origins. Behavioral clues include social withdrawal, diminished productivity, and coping mechanisms centered on somatic concerns, such as frequent medical consultations without acknowledging emotional turmoil.^[26] Impaired social functioning manifests as isolation or agitation, further concealing the depressive core.^[26] Reduced productivity at work or home often accompanies these patterns, with patients channeling energy into hypochondriacal behaviors like excessive health monitoring.^[12] The interplay between these psychological features and somatic symptoms creates a reinforcing cycle of distress, where anxiety and cognitive pessimism amplify physical complaints, while somatic focus perpetuates emotional avoidance.^[17] This dynamic, noted in psychosomatic literature, underscores how hidden irritability or anhedonia can intensify unexplained pains or fatigue, delaying recognition of the underlying depression. Contemporary views integrate these presentations into major depressive disorder with somatic features or somatic symptom disorder, as per DSM-5 (2013) and ongoing research as of 2025.^[27]

Diagnosis

Challenges in Diagnosis

Masked depression poses significant diagnostic challenges primarily because it manifests through predominant somatic symptoms, such as chronic pain or gastrointestinal disturbances, rather than overt emotional distress, leading clinicians to initially attribute these to primary physical disorders like hypochondriasis or chronic fatigue syndrome.^[2] This misdirection often results in unnecessary diagnostic tests, such as laboratory or radiological investigations, and ineffective interventions focused solely on somatic relief, delaying recognition of the underlying depressive condition.^[6] For instance, somatic complaints may overlap with conditions like pain disorders, complicating differential diagnosis and prompting treatment as isolated medical issues.^[6] Patient-related factors exacerbate these difficulties, including denial of emotional components due to mental health stigma, which discourages acknowledgment of psychological symptoms. In cultures where mental illness is viewed as a sign of weakness or shame, such as in certain Middle Eastern societies, individuals may exclusively report bodily symptoms to avoid social repercussions, further masking the depression.^[27] Additionally, lack of insight into one's condition can lead patients to underreport mood-related issues, hindering accurate assessment.^[6] Clinician factors also contribute substantially, with biases toward the biomedical model in primary care settings often prioritizing organic explanations for symptoms over psychosomatic ones. Primary care providers, trained predominantly in biomedical approaches, may overlook the psychological underpinnings of somatic presentations due to undertraining in psychosomatic medicine and time constraints during consultations.^[28] This leads to a reluctance to explore depressive histories or collateral information, particularly when patients deny sadness, resulting in initial exams that miss the diagnosis.^[2] The consequences of these diagnostic challenges are profound, as delayed identification prolongs the depressive state, increasing the risk of chronicity and comorbidity with conditions like anxiety disorders. Untreated masked depression can impair social and occupational functioning, elevate suicide risk, and drive up healthcare costs through repeated consultations and interventions for presumed physical ailments.^[6] Overall, these barriers underscore the need for heightened awareness to mitigate poorer long-term outcomes.^[2]

Assessment Methods

Assessment of masked depression relies on a combination of screening instruments that emphasize somatic presentations alongside mood symptoms, as traditional depression scales may overlook cases where psychological distress manifests primarily through physical complaints. The Patient Health Questionnaire-9 (PHQ-9) is commonly used for this purpose, with its items on somatic aspects like fatigue, sleep disturbances, and appetite changes helping to identify underlying depression in patients presenting with unexplained physical symptoms; scores of 10 or higher indicate moderate severity warranting further evaluation.^[29] Similarly, the Beck Depression Inventory-II (BDI-II), a 21-item self-report measure, assesses somatic and cognitive symptoms of depression and shows reliability through scores correlating with clinical diagnoses, though self-reports may be subject to biases such as under-reporting when emotional distress is minimized.^[29] The Zung Self-Rating Depression Scale (SDS) serves as a valuable screening tool in primary care settings, where it has identified masked depression in approximately 12% of patients with somatic complaints, facilitating early intervention by quantifying symptom severity on a 20-item scale.^[30] For a focused evaluation of somatic elements, the Patient Health Questionnaire-15 (PHQ-15) quantifies the burden of 15 common physical symptoms, such as pain and gastrointestinal issues, and is recommended for monitoring somatization that may signal masked depression, with cutpoints of 5, 10, or 15 denoting low, medium, or high levels.^[31] Clinical interviews form the cornerstone of assessment, involving a detailed exploration of psychosocial history to uncover hidden mood symptoms amid predominant somatic complaints like chronic pain or insomnia. Techniques include open-ended questioning to probe for subtle signs of anhedonia or irritability, while systematically ruling out organic causes through comprehensive physical examinations and laboratory tests, such as thyroid function assays or complete blood counts, as emphasized by nonpsychiatric clinicians who prioritize these to differentiate masked depression from medical conditions.^[2] Longitudinal monitoring during follow-up interviews tracks symptom evolution, allowing clinicians to observe if somatic issues persist despite treatment for presumed physical ailments, thereby revealing the depressive etiology. A multidisciplinary approach enhances accuracy, involving collaboration among primary care physicians, psychiatrists, and psychologists to integrate medical, psychiatric, and psychological perspectives. Primary care providers often initiate screening with tools like the PHQ-15, while psychiatrists conduct specialized interviews to confirm diagnosis, and psychologists contribute behavioral assessments; this teamwork is particularly vital in settings like general practice, where masked depression is frequently encountered.^[2] Differential diagnosis requires distinguishing masked depression from conditions with overlapping somatic features, such as somatic symptom disorder, where excessive health anxiety predominates without clear depressive mood changes, or generalized anxiety disorder marked by worry rather than low mood. Medical mimics like hypothyroidism or chronic fatigue syndrome must be excluded via targeted labs and imaging, ensuring that somatic symptoms are not attributable to organic pathology before attributing them to depression.^[2]

Epidemiology

Prevalence

Masked depression, characterized by predominant somatic symptoms masking underlying affective disturbances, is estimated to comprise a substantial proportion of depression cases encountered in primary care settings. International studies indicate that between 30% and 70% of patients diagnosed with major depression in primary care present primarily with physical complaints such as pain, fatigue, or gastrointestinal issues, rather than overt psychological symptoms.^[32]^[33] In specialized somatic clinics, this figure can rise, with one study reporting that approximately 38% of identified depression cases among patients seeking care for unexplained physical symptoms exhibit a somatized presentation.^[34] These estimates highlight the condition's prominence in non-psychiatric medical environments, where somatic dominance often delays recognition. Specific research underscores variations across populations. A 2022 cross-sectional study of 469 fertile couples in Jordan and Palestine revealed that 31.6% experienced moderate to severe depression, frequently manifesting with masked features alongside anxiety symptoms, with higher severity noted in the Palestinian subsample (mean Beck Depression Inventory score of 21.8 compared to 11.1 in Jordan).^[27] Historical data from the 1970s and 1980s, when the concept gained traction, similarly pointed to notable rates, suggesting underdetection in routine care. The condition appears more prevalent in primary care than in psychiatric settings, where patients are more inclined to articulate emotional distress, leading to lower masking rates. Community surveys tend to underreport masked depression, as affected individuals typically pursue somatic evaluations rather than mental health assessments, contributing to obscured epidemiological data. While empirical recognition remains consistent, the terminology and diagnostic emphasis have shifted since the 1990s, with declining use of "masked depression" amid evolving paradigms that prioritize integrated symptom assessment, potentially influencing contemporary prevalence reporting.^[2] This evolution, coupled with ongoing debates about the construct's validity, may result in slightly conservative estimates in recent literature. As of 2025, no major new studies specifically on "masked depression" have emerged, but research continues to emphasize somatic presentations in primary care depression cohorts.

Risk Factors and Demographics

Masked depression is more prevalent among men, particularly due to societal norms that discourage emotional expression and promote stoicism, leading to the masking of psychological symptoms with somatic complaints or behavioral changes such as overworking or substance use.^[35] This pattern is exacerbated by gender roles that emphasize self-reliance, resulting in underdiagnosis as men may not recognize or report classic depressive symptoms.^[36] In older adults, especially elderly men, masked depression often manifests through a predominance of physical symptoms like fatigue, pain, or sleep disturbances, which can be misattributed to aging or comorbidities.^[6] Risk is heightened in this demographic by conditions such as hypertension, silent cerebrovascular disease, and metabolic syndrome, which cluster with subsyndromal depressive profiles.^[37] Cultural factors play a significant role, with higher rates observed in certain non-Western populations, including East Asian groups, where mental health stigma leads to somatization and concealment of emotional distress.^[38] In these contexts, family and societal expectations prioritize physical over psychological explanations, amplifying the masking of depression.^[39] Similar patterns have been noted in Middle Eastern populations, as evidenced by studies in Jordan and Palestine.^[27] Clinically, a history of chronic physical illnesses, such as cardiovascular disease or diabetes, increases susceptibility, as does noncompliance with medical treatments, which may signal underlying unaddressed depression.^[2] Comorbid conditions like anxiety disorders or substance use further contribute, often serving as alternative outlets for emotional suppression.^[36] Psychosocial elements, including occupational stress, low socioeconomic status, and rigid gender expectations, elevate risk by fostering environments where emotional vulnerability is stigmatized.^[35] Unemployment and financial strain, for instance, correlate with intensified masking behaviors in affected individuals.^[27] Protective factors include greater mental health awareness in educated populations and Western cultural contexts, where reduced stigma may encourage earlier recognition and less masking of symptoms.^[40]

Controversies and Current Status

Validity and Disputes

Critics have long argued that masked depression does not represent a unique syndrome but rather an artifact resulting from inadequate diagnostic assessment in primary care settings, where somatic complaints overshadow psychological symptoms.^[18] This perspective posits that what is labeled as masked depression often reflects incomplete evaluation rather than a distinct clinical entity.^[18] Furthermore, the concept overlaps significantly with somatic symptom disorder as defined in the DSM-5, which emphasizes excessive distress from somatic symptoms without requiring them to be medically unexplained, leading to debates about whether masked depression adds diagnostic value beyond this broader category.^[17] Supporting evidence for masked depression as a recognizable pattern includes studies identifying distinct neurobiological markers, such as alterations in pain processing pathways shared between depression and chronic pain conditions, involving overlapping neurotransmitters like serotonin and norepinephrine.^[41] For instance, functional brain imaging has revealed heightened activity in the anterior cingulate cortex and insula in individuals with comorbid depression and somatic pain, suggesting a biological basis for the presentation.^[42] Additionally, clinical trials demonstrate improved outcomes with targeted interventions; in one general practice study, 66% of patients with identified masked depression showed significant symptom reduction after treatment with alprazolam, compared to 35% spontaneous improvement in untreated controls, highlighting the benefits of psychiatric recognition and referral.^[30] Cultural critiques of the masked depression concept highlight its potential to pathologize normal somatic expressions of distress in non-Western contexts, where physical symptoms like fatigue or heart-related complaints are common idioms of emotional suffering rather than hidden psychopathology.^[43] In regions such as East Asia and Latin America, these presentations reflect cultural norms of bodily-focused distress, raising concerns that Western-centric diagnostic frameworks may misinterpret them as masked psychiatric illness.^[43] Original formulations of masked depression have also been criticized for gender bias, often framing male presentations as externalizing or somatic to fit stereotypes of masculinity, thereby underemphasizing internal emotional experiences in men.^[44] In modern perspectives, masked depression is increasingly viewed as a useful clinical heuristic for prompting comprehensive assessment in patients with prominent somatic features, rather than a formal diagnosis, given its exclusion from DSM-5 and ICD-11 classifications.^[17] This shift emphasizes a biopsychosocial approach to somatization in depression, with ongoing calls for longitudinal research to clarify its prognostic implications and differentiate it from other somatic disorders over time.^[27]

Official Recognition

Masked depression is not listed as a distinct diagnostic entity in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5, published in 2013) or its text revision (DSM-5-TR, 2022).^[45] Instead, presentations resembling masked depression—characterized by predominant somatic complaints—are typically subsumed under major depressive disorder (MDD) when full criteria are met, particularly with emphasis on somatic symptom features, or classified as other specified depressive disorder if depressive symptoms cause significant distress or impairment but do not fulfill criteria for MDD or persistent depressive disorder.^[45] In the International Classification of Diseases, Eleventh Revision (ICD-11, effective 2019), masked depression is also absent as a specific category.^[3] Somatic symptoms associated with depressive states are instead addressed within broader frameworks, such as bodily distress disorder (6B40), which encompasses persistent bodily complaints not fully explained by medical conditions and often linked to psychological factors including depression.^[3] Historically, masked depression received provisional recognition in earlier classification systems, including the ICD-9 during the 1970s, where it served as a descriptive category for atypical depressive episodes masked by somatic or behavioral symptoms rather than overt mood changes.^[46] This acknowledgment reflected the concept's popularity in clinical literature from the mid-20th century, but while it was retained in ICD-10 (effective 1994) under F32.8 Other depressive episodes as "single episodes of 'masked' depression NOS," it was excluded in the transition to ICD-11 due to insufficient diagnostic specificity, reliability, and validity in distinguishing it as a unique syndrome.^[47]^[3] The current diagnostic landscape implies that masked depression should be employed as a clinical specifier rather than an independent diagnosis, aiding practitioners in identifying and addressing somatic-dominant depressive presentations within established categories like MDD to improve recognition and management.^[2]^[27]

Management

Treatment Approaches

Treatment approaches for masked depression prioritize interventions that address both the concealed emotional components and the prominent somatic symptoms, often requiring adaptations to standard depression protocols. Pharmacological options commonly include serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine, which alleviate both pain and mood symptoms in 30–70% of cases independently of antidepressant effects.^[1] Selective serotonin reuptake inhibitors (SSRIs) such as sertraline effectively target mood dysregulation, anxiety, and associated somatic manifestations like pain or fatigue.^[17]^[6] Tricyclic antidepressants (TCAs) serve as an alternative, particularly beneficial at low doses for alleviating chronic pain while full doses manage underlying depression; SNRIs may also be considered for their dual action on pain and mood.^[6]^[17] Adjunctive analgesics can be integrated to provide targeted relief for persistent physical symptoms, ensuring a balanced approach that avoids over-reliance on symptom suppression alone.^[17] Psychotherapeutic modalities play a central role in uncovering and reframing the emotional roots obscured by somatic complaints. Cognitive-behavioral therapy (CBT) is particularly effective, guiding patients to identify and modify patterns of thought that amplify physical focus while fostering recognition of depressive affect.^[17]^[6]^[48] Mindfulness-based therapies complement CBT by promoting non-judgmental awareness of bodily sensations, thereby reducing psychosomatic distress and enhancing emotional regulation.^[17] Multidisciplinary care coordinates primary medical evaluation and treatment of somatic issues with psychiatric expertise to facilitate holistic management and improve patient outcomes.^[2] Lifestyle interventions, such as structured exercise and nutritional adjustments, are incorporated to mitigate the physical burden of symptoms and bolster resilience against depressive episodes. Patient education forms a foundational element, emphasizing the interplay between mind and body to encourage treatment adherence, dispel stigma, and empower individuals to actively participate in their recovery process.^[50]^[2]

Prognosis

The prognosis for masked depression, characterized by predominant somatic symptoms masking affective ones, is similar to that of major depressive disorder but often involves poorer response to standard antidepressants and prolonged remission times compared to typical MDD.^[1] Response rates to first-line interventions such as antidepressants may be lower than the 50-60% observed in typical MDD.^[51]^[52] However, delayed diagnosis—often due to the atypical presentation—can prolong the illness course, increasing the risk of chronicity and reducing overall remission chances compared to typical depression.^[53]^[54] Early intervention, particularly within the first few months of symptom onset, significantly enhances recovery potential by preventing escalation of somatic complaints into entrenched patterns.^[17] Untreated or late-diagnosed masked depression carries elevated risks of complications, including higher rates of functional disability, cognitive decline, and mortality. In elderly patients with nondysphoric (masked-like) presentations, long-term follow-up over 13 years reveals a 1.7-fold increased mortality risk and up to 5-fold higher odds of instrumental activities of daily living impairment, independent of baseline comorbidities.^[55] Suicidality may also intensify if somatic symptoms lead to repeated medical consultations without addressing the underlying mood disorder, potentially resulting in treatment nonadherence and somatic escalation.^[2] Prognostic outcomes improve with factors such as younger age at onset and robust social support, which facilitate adherence and holistic management, whereas elderly patients or those with medical comorbidities face poorer trajectories due to overlapping symptoms and diagnostic overshadowing.^[55]^[17] Longitudinal studies indicate that combined pharmacotherapy and psychotherapy yield 60-80% symptom improvement rates in responsive cases, though relapse occurs in approximately 30% without ongoing maintenance strategies.^[56]^[57]

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Sep 15, 2023 · The core symptoms of depression are reported to be depressed mood (eg, feeling sad, down or hopeless) and markedly diminished interest or pleasure in ...
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Pharmacologic Treatment of Depression - AAFP
Approximately 50% of patients older than 65 years who have depression report at least a 50% improvement in symptoms with antidepressant use. Although prior ...
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[PDF] Treatment for Depression After Unsatisfactory Response to SSRIs ...
The rate of treatment response following first-line treatment with SSRIs is moderate, varying from 40 to 60 percent; remission rates vary from 30 to 45 ...
[52]
Masking Depression: Signs and Strategies for Support
Jan 14, 2025 · The term masked depression gained attention in the 1970s and 1980s, though it is no longer an official diagnosis in the latest editions of the ...
[53]
Factors associated with delayed diagnosis of mood and/or anxiety ...
A delay in treatment of common mental disorders is associated with poorer health outcomes including a worsening of mental health status, the development of ...Missing: masked | Show results with:masked
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Depression Without Sadness: Functional Outcomes of Nondysphoric ...
Apr 27, 2015 · ... long-term outcomes. This prospective study investigates how mood ... Terms such as masked depression, atypical depression, ...
[55]
Evidence-Based Applications of Combination Psychotherapy and ...
More recent studies have produced inconsistent results, with some studies finding that combination treatment reduced depressive symptoms significantly more ...
[56]
Recovery and Recurrence Following Treatment for Adolescent ...
Eighty percent recovered, with no differences among treatments. However, 30% of recovered adolescents had 1 recurrence and 8% had 2 recurrences.